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https://www.readbyqxmd.com/read/28087712/pdx1-dynamically-regulates-pancreatic-ductal-adenocarcinoma-initiation-and-maintenance
#1
Nilotpal Roy, Kenneth K Takeuchi, Jeanine M Ruggeri, Peter Bailey, David Chang, Joey Li, Laura Leonhardt, Sapna Puri, Megan T Hoffman, Shan Gao, Christopher J Halbrook, Yan Song, Mats Ljungman, Shivani Malik, Christopher V E Wright, David W Dawson, Andrew V Biankin, Matthias Hebrok, Howard C Crawford
Aberrant activation of embryonic signaling pathways is frequent in pancreatic ductal adenocarcinoma (PDA), making developmental regulators therapeutically attractive. Here we demonstrate diverse functions for pancreatic and duodenal homeobox 1 (PDX1), a transcription factor indispensable for pancreas development, in the progression from normal exocrine cells to metastatic PDA. We identify a critical role for PDX1 in maintaining acinar cell identity, thus resisting the formation of pancreatic intraepithelial neoplasia (PanIN)-derived PDA...
December 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/28086968/microbiota-fingerprints-lose-individually-identifying-features-over-time
#2
David Wilkins, Marcus H Y Leung, Patrick K H Lee
BACKGROUND: Humans host individually unique skin microbiota, suggesting that microbiota traces transferred from skin to surfaces could serve as forensic markers analogous to fingerprints. While it is known that individuals leave identifiable microbiota traces on surfaces, it is not clear for how long these traces persist. Moreover, as skin and surface microbiota change with time, even persistent traces may lose their forensic potential as they would cease to resemble the microbiota of the person who left them...
January 9, 2017: Microbiome
https://www.readbyqxmd.com/read/28081474/the-future-excess-fraction-of-occupational-cancer-among-those-exposed-to-carcinogens-at-work-in-australia-in-2012
#3
Renee N Carey, Sally J Hutchings, Lesley Rushton, Timothy R Driscoll, Alison Reid, Deborah C Glass, Ellie Darcey, Si Si, Susan Peters, Geza Benke, Lin Fritschi
BACKGROUND: Studies in other countries have generally found approximately 4% of current cancers to be attributable to past occupational exposures. This study aimed to estimate the future burden of cancer resulting from current occupational exposures in Australia. METHODS: The future excess fraction method was used to estimate the future burden of occupational cancer (2012-2094) among the proportion of the Australian working population who were exposed to occupational carcinogens in 2012...
January 9, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28081245/sharp-tailed-grouse-nest-survival-and-nest-predator-habitat-use-in-north-dakota-s-bakken-oil-field
#4
Paul C Burr, Aaron C Robinson, Randy T Larsen, Robert A Newman, Susan N Ellis-Felege
Recent advancements in extraction technologies have resulted in rapid increases of gas and oil development across the United States and specifically in western North Dakota. This expansion of energy development has unknown influences on local wildlife populations and the ecological interactions within and among species. Our objectives for this study were to evaluate nest success and nest predator dynamics of sharp-tailed grouse (Tympanuchus phasianellus) in two study sites that represented areas of high and low energy development intensities in North Dakota...
2017: PloS One
https://www.readbyqxmd.com/read/28081053/notes-from-the-field-occupational-lead-exposures-at-a-shipyard-douglas-county-wisconsin-2016
#5
Debora Weiss, Stephanie J Yendell, Luke A Baertlein, Krista Y Christensen, Carrie D Tomasallo, Paul D Creswell, Jenny L Camponeschi, Jon G Meiman, Henry A Anderson
No abstract text is available yet for this article.
January 13, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28079622/prevalence-and-determinants-of-job-stress-in-patients-with-inflammatory-bowel-disease
#6
Philipp Schreiner, Luc Biedermann, Jean-Benoit Rossel, Gerhard Rogler, Valérie Pittet, Roland von Känel
BACKGROUND: Psychosocial factors have been shown to predict a poor disease course in patients with inflammatory bowel disease (IBD), but whether this applies to job stress is currently unknown. We assessed the prevalence of job stress and its correlates in a large cohort of patients with IBD. METHODS: We included all adult, professionally active patients enrolled between 2006 and 2015 in the Swiss IBD Cohort. Job stress was measured through the self-report effort-reward imbalance ratio and overcommitment (OC) to work questionnaires...
January 10, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28079614/the-role-of-gene-environment-interplay-in-occupational-and-environmental-diseases-current-concepts-and-knowledge-gaps
#7
Elizabeth Kwo, David Christiani
PURPOSE OF REVIEW: The interplay between genetic susceptibilities and environmental exposures in the pathogenesis of a variety of diseases is an area of increased scientific, epidemiologic, and social interest. Given the variation in methodologies used in the field, this review aims to create a framework to help understand occupational exposures as they currently exist and provide a foundation for future inquiries into the biological mechanisms of the gene-environment interactions. Understanding of this complex interplay will be important in the context of occupational health, given the public health concerns surrounding a variety of occupational exposures...
January 11, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28079324/-the-informal-economy-an-occupational-health-issue
#8
José Luis Carretero Ares, Begoña Cueva Oliver, Asunción Vidal Martínez, María Vicenta Rigo Martínez, José Rafael Lobato Cañón
Informal economy must be differentiated from concepts such as informal employment and the informal sector, each with its own characteristics. There are several types of informal workers that are grouped into several categories according to their work. The families of these workers are grouped into vulnerable job, which is also not beneficial for health coverage. Informal working conditions mean great morbidity resulting in economic losses and a large number of quality-adjusted life year, especially among young populations and women...
January 2017: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/28079323/-fitness-for-duty-and-psychophysical-fitness-in-hazardous-occupations
#9
Ana Santaularia Morros, Jordi-Carles Schlaghecke I Gras
No abstract text is available yet for this article.
January 2017: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/28079322/-incidence-of-non-work-related-sickness-absence-in-spain-by-economic-activity-of-the-company
#10
Fernando G Benavides, Elena Zaballa, Xavier Duran, Victòria Sanchez-Niubo, David Gimeno Ruiz de Porras
INTRODUCTION: The management of sickness absence due to non-work-related diseases in Spain has typically focused on the control of its duration. The goal of this study was to provide estimates for the incidence of sickness absence due to nonwork-related diseases by economic activity to help shift the focus of management of sickness absence towards prevention. METHODS: Retrospective study based on 646,337 workers and 133,812 episodes of sickness absence started in 2009, from the Working Continuous Life Sample...
January 2017: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/28079320/-work-and-health-in-portugal-2016-first-report-on-occupational-health-in-portugal
#11
EDITORIAL
Teresa Monjardino, Raquel Lucas, Fernando G Benavides
No abstract text is available yet for this article.
January 2017: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/28079279/evaluating-predictors-of-lead-exposure-for-activities-disturbing-materials-painted-with-or-containing-lead-using-historic-published-data-from-u-s-workplaces
#12
Sarah J Locke, Nicole C Deziel, Dong-Hee Koh, Barry I Graubard, Mark P Purdue, Melissa C Friesen
OBJECTIVES: We evaluated predictors of differences in published occupational lead concentrations for activities disturbing material painted with or containing lead in U.S. workplaces to aid historical exposure reconstruction. METHODS: For the aforementioned tasks, 221 air and 113 blood lead summary results (1960-2010) were extracted from a previously developed database. Differences in the natural log-transformed geometric mean (GM) for year, industry, job, and other ancillary variables were evaluated in meta-regression models that weighted each summary result by its inverse variance and sample size...
February 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28079278/corporate-corruption-of-science-another-asbestos-example
#13
REVIEW
David Egilman, Rubén Monárrez
BACKGROUND: Kelsh et al. [2007]: Occup Med (Lond) 57:581-589 published a paper reanalyzing one of the few data sources publicly available on mesothelioma amongst brake workers, the Australian Mesothelioma Surveillance Registry (AMSR). This reanalysis was commissioned by lawyers representing the automobile manufacturing companies and did not align with an independent analysis published by Leigh and Driscoll [2003]: Occup Environ Health 9:206-217. METHODS: We sought to reevaluate the AMSR data ourselves to understand how the company-sponsored research categorized the data...
February 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28079277/whole-body-vibration-exposure-of-occupational-horseback-riding-in-agriculture-a-ranching-example
#14
Xiaoke Zeng, Catherine Trask, Aaron M Kociolek
BACKGROUND: Horse riding is common in many occupations; however, there is currently no research evaluating exposure to whole-body vibration and mechanical shock on horseback. METHODS: Whole-body vibration was measured on a cattle rancher during two 30 min horseback rides using a tri-axial accelerometer mounted on a western saddle. Vibration was summarized into standardized metrics, including the 8 hr equivalent root-mean-squared acceleration (A[8]) and the daily 4th power vibration dose value (VDV)...
February 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28079081/sideband-cooling-beyond-the-quantum-backaction-limit-with-squeezed-light
#15
Jeremy B Clark, Florent Lecocq, Raymond W Simmonds, José Aumentado, John D Teufel
Quantum fluctuations of the electromagnetic vacuum produce measurable physical effects such as Casimir forces and the Lamb shift. They also impose an observable limit-known as the quantum backaction limit-on the lowest temperatures that can be reached using conventional laser cooling techniques. As laser cooling experiments continue to bring massive mechanical systems to unprecedentedly low temperatures, this seemingly fundamental limit is increasingly important in the laboratory. Fortunately, vacuum fluctuations are not immutable and can be 'squeezed', reducing amplitude fluctuations at the expense of phase fluctuations...
January 11, 2017: Nature
https://www.readbyqxmd.com/read/28078811/the-effects-of-nanomaterials-on-blood-coagulation-in-hemostasis-and-thrombosis
#16
REVIEW
Jan Simak, Silvia De Paoli
The blood coagulation balance in the organism is achieved by the interaction of the blood platelets (PLTs) with the plasma coagulation system (PCS) and the vascular endothelial cells. In healthy organism, these systems prevent thrombosis and, in events of vascular damage, enable blood clotting to stop bleeding. The dysregulation of hemostasis may cause serious thrombotic and/or hemorrhagic pathologies. Numerous engineered nanomaterials are being investigated for biomedical purposes and are unavoidably exposed to the blood...
January 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28078438/biological-monitoring-of-cobalt-in-hard-metal-factory-workers
#17
Andrea Princivalle, Ivo Iavicoli, Marzia Cerpelloni, Antonia Franceschi, Maurizio Manno, Luigi Perbellini
PURPOSE: The main aim of this study was to investigate the cobalt (Co) concentrations in urine along 4 months and their relationship with Co concentrations in blood and haemoglobin (adducts) in 34 workers from a hard metal manufacturing plant where metallic Co and Co oxide were used. Furthermore, the excretion kinetics of Co was investigated and the half-lives of Co in blood, plasma and urine were calculated along 18 days of non-exposure in the same workers. METHODS: Co was analysed, in all biological samples, by ICP/MS...
January 11, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28078092/severe-obesity-emotions-and-eating-habits-a-case-control-study
#18
M Koski, H Naukkarinen
BACKGROUND: Obesity has a multifaceted etiology that involves genetic, biological and behavioral factors, body growth, eating habits, energy expenditure and the function of adipose tissue. The present study aimed to expand upon knowledge about the relationships among obesity, emotions and eating habits in severely obese individuals using a case-control method. METHODS: The subject group consisted of 112 individuals (81 females and 31 males) receiving a permanent disability pension primarily for obesity...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28077896/study-of-scientific-production-of-community-medicines-department-indexed-in-isi-citation-databases
#19
Mohammad Khademloo, Ali Akbar Khaseh, Hasan Siamian, Kobra Aligolbandi, Mahsoomeh Latifi, Mousa Yaminfirooz
BACKGROUND: In the scientometric, the main criterion in determining the scientific position and ranking of the scientific centers, particularly the universities, is the rate of scientific production and innovation, and in all participations in the global scientific development. One of the subjects more involved in repeatedly dealt with science and technology and effective on the improvement of health is medical science fields. In this research using scientometric and citation analysis, we studied the rate of scientific productions in the field of community medicine, which is the numbers of articles published and indexed in ISI database from 2000 to 2010...
October 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28077823/association-of-health-symptoms-with-low-level-exposure-to-organophosphates-dna-damage-ache-activity-and-occupational-knowledge-and-practice-among-rice-corn-and-double-crop-farmers
#20
Surat Hongsibsong, Nalin Sittitoon, Ratana Sapbamrer
OBJECTIVES: This study aims to determine (1) total dialkylphosphate (ΣDAP) levels, occupational knowledge and practice, DNA damage, AChE activity, and health symptoms in rice, corn, and double-crop farmers; (2) the association of health symptoms with ΣDAP levels, occupational knowledge and practice, DNA damage, and AChE activity in farmers; and (3) the prevalence of health symptoms between farmers and non-farmers. METHODS: A cross-sectional study was conducted by interviewing as well as analyzing urine and blood samples during July to August 2014...
January 11, 2017: Journal of Occupational Health
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