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Rheumatoid arthritis

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https://www.readbyqxmd.com/read/28931060/isolated-positive-anti-ss-b-autoantibodies-are-not-related-to-clinical-features-of-systemic-autoimmune-diseases-results-from-a-routine-population-survey
#1
Sabine Jardel, Nicole Fabien, Arnaud Hot, Sandra Vukusic, Jacques Tebib, Vincent Cottin, Pascal Sève, Maurice Laville, Alexandre Belot, Isabelle Durieu, Lorna Garnier, Frédéric Coutant, Quitterie Reynaud, Jean Christophe Lega
OBJECTIVE: To assess in clinical practice the frequency and diagnosis associated with the SS-B-positive/SS-A negative autoantibody profile. METHODS: We analyzed a one-year consecutive population of 624 patients referred by clinicians to the immunology laboratory to investigate anti-SS-A and/or anti-SS-B autoantibodies, who were detected using luminex technology. Data were analyzed for patients with isolated anti-SS-B autoantibodies. The clinical characteristics and diagnosis of connective tissue diseases (CTD) were retrieved according to the international criteria...
2017: PloS One
https://www.readbyqxmd.com/read/28930898/it-s-all-in-the-wrist-diagnosis-and-management-of-carpal-tunnel-syndrome
#2
Catherine O Durham, Kathy VanRavenstein
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy accounting for 90% of similar disorders, occurring in 3.8% of the population, common in adults aged 40-60 years, and is associated with an average 32 lost days of work and lost productivity. In addition to occupational exposure, there are several common chronic disorders that can preclude CTS, obesity, diabetes mellitus, rheumatoid arthritis, pregnancy, metabolic syndrome, and thyroid disorder, to name a few. Therefore, it is important for the primary care provider to have knowledge in this syndrome...
September 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28930753/camel-milk-attenuates-rheumatoid-arthritis-via-inhibition-of-mitogen-activated-protein-kinase-pathway
#3
Hany H Arab, Samir A Salama, Tamer M Abdelghany, Hany A Omar, El-Shaimaa A Arafa, Majed M Alrobaian, Ibrahim A Maghrabi
BACKGROUND/AIMS: Camel milk (CM) has shown beneficial anti-inflammatory actions in several experimental and clinical settings. So far, its effect on rheumatoid arthritis (RA) has not been previously explored. Thus, the current work aimed to evaluate the effects of CM in Adjuvant-induced arthritis and air pouch edema models in rats, which mimic human RA. METHODS: CM was administered at 10 ml/kg orally for 3 weeks starting on the day of Freund's adjuvant paw inoculation...
September 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28930656/more-is-less-il-9-in-the-resolution-of-inflammation
#4
Fotios Karagiannis, Christoph Wilhelm
In a recent study in Nature Medicine, Rauber et al. (2017) identify interleukin-9 (IL-9) derived from group 2 innate lymphoid cells as crucial regulators inducing resolution of chronic inflammation in rheumatoid arthritis. Their findings provide insight into the varied functions of IL-9 and open the door to novel therapeutic interventions.
September 19, 2017: Immunity
https://www.readbyqxmd.com/read/28930556/osteoimmunology-the-nexus-between-bone-and-immune-system
#5
Hamid Y Dar, Zaffar Azam, Rajaneesh Anupam, Rajesh K Mondal, Rupesh K Srivastava
Osteoimmunology is an interdisciplinary research field which combines the existing fields of osteology (bone biology) and immunology under one umbrella. The observation that contributed enormously to the emergence of osteoimmunology as an independent field of investigation was the enhanced bone loss in various inflammatory bone diseases such as rheumatoid arthritis, osteoporosis and periodontitis. T helper cells (Th1, Th2, Treg and Th17) along with various other immune cells (B cells, DC, macrophages etc.) are actively involved in bone homeostasis...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930550/strategies-for-reducing-inflammation-and-promoting-bone-repair-in-arthritis
#6
Manoel Figueiredo Neto, Hiroki Yokota, Marxa L Figueiredo
Chronic forms of arthritis encompass many joint inflammatory disorders, including rheumatoid arthritis (RA), an autoimmune inflammatory disease, and osteoarthritis (OA), typically a 'wear and tear' condition that is now known to also have an inflammatory etiology. The impact of inflammation in the disease prognosis and joint degradation due to impaired repair mechanisms has long been recognized for RA, and now also for OA. Both forms of arthritis are prevalent chronic health conditions, and despite recent advances, their treatment still represents an unmet medical need because of safety and efficacy concerns with currently prescribed drugs...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929423/oxidative-stress-in-inflammatory-cells-of-patient-with-rheumatoid-arthritis-clinical-efficacy-of-dietary-antioxidants
#7
REVIEW
Asis Bala, Chaitali Mondal, Pallab Kanti Haldar, Bidita Khandelwal
Rheumatoid arthritis (RA) is an autoimmune disease responsible for significant human morbidity in modern life. However, oxidative stress is one of the key markers for determining pathophysiology of patients with RA. The interaction between cellular immune system and body's endogenous and/or exogenous antigens produce reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune disease like RA. ROS and RNS include highly toxic superoxide (O2(-)) and peroxynitrite (ONOO(-)) radicals, which activate the signaling cascades of inflammatory cells to synthesize pro-inflammatory cytokines and chemokines...
September 19, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28929342/perception-of-originator-biologics-and-biosimilars-a-survey-among-belgian-rheumatoid-arthritis-patients-and-rheumatologists
#8
Eline van Overbeeke, Birgit De Beleyr, Jan de Hoon, Rene Westhovens, Isabelle Huys
BACKGROUND: Among patients and rheumatologists, current knowledge and perception of biosimilars in comparison with originator biologics is unknown. OBJECTIVES: The aim of this study was to investigate this knowledge and perception in Belgian rheumatologists and rheumatoid arthritis (RA) patients. METHODS: Anonymous web surveys were conducted in Belgian RA patients (n = 121) and rheumatologists (n = 41) during the period January-March 2016...
September 19, 2017: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/28929232/-prevalence-comorbidity-and-interdisciplinary-treatment-of-rheumatoid-arthritis-insurance-data-on-outpatient-and-inpatient-care-in-baden-w%C3%A3-rttemberg
#9
A Strahl, O Schneider, J Frankenhauser-Mannuß, S Knapstein, C Hermann, B Lembeck, H-M Lorenz, W Rüther, J Flechtenmacher
BACKGROUND: Rheumatoid arthritis (RA) has an increased number of comorbidities compared with the general population. OBJECTIVE: Study aim was to collect epidemiological data on prevalence, incidence and comorbidities of RA as well as utilization of outpatient and inpatient care services. MATERIAL AND METHODS: In an age and gender-adjusted case control study, a total of 3.4 million patients insured by the AOK Baden-Württemberg were analysed with respect to visits to physicians, prevalence, incidence and comorbidities of RA...
September 19, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28928840/a-cytokine-signal-inhibitor-for-rheumatoid-arthritis-enhances-cancer-metastasis-via-depletion-of-nk-cells-in-an-experimental-lung-metastasis-mouse-model-of-colon-cancer
#10
Hideki Shimaoka, Shinsuke Takeno, Kenji Maki, Takahide Sasaki, Suguru Hasegawa, Yuichi Yamashita
Current therapy for rheumatoid arthritis (RA) relies on global suppression of the immune response or specific blockade of inflammatory cytokines. However, it is unclear how immunosuppressants affect patients with cancer. Therefore, in the present study, the effect of three biological agents, tofacitinib, anti-mouse IL-6 receptor antibody (MR16-1) and etanercept, which are used for the treatment of RA diseases, on a tumor-bearing mouse model was investigated. The effect of the three agents was examined using a mouse lung-metastasis model with the murine colon 26 cancer cell line...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928392/mucosa-associated-lymphoid-tissue-lymphoma-translocation-1-as-a-novel-therapeutic-target-for-rheumatoid-arthritis
#11
Chang Hoon Lee, Su Jeong Bae, Miok Kim
Emerging evidence suggests that mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) is a key regulator of inflammatory diseases; however, the pathological role of MALT1 in rheumatoid arthritis (RA) is not well understood. Consequently, this protein has not been therapeutically targeted for the treatment of RA. MALT1 plays a role in the paracaspase pathway, has proteolytic activity and is involved in the regulation of inflammatory responses. In this study, we found that the MALT1-targeting inhibitory small molecule, MALT1 selective inhibitor 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide (MI-2) strongly suppresses the differentiation of monocytes into osteoclasts in the absence or presence of the inflammatory cytokine tumour necrosis factor α...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927867/cardiovascular-autonomic-regulation-inflammation-and-pain-in-rheumatoid-arthritis
#12
Ahmed M Adlan, Jet J C S Veldhuijzen van Zanten, Gregory Y H Lip, Julian F R Paton, George D Kitas, James P Fisher
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory condition characterised by reduced heart rate variability (HRV) of unknown cause. We tested the hypothesis that low HRV, indicative of cardiac autonomic cardiovascular dysfunction, was associated with systemic inflammation and pain. Given the high prevalence of hypertension (HTN) in RA, a condition itself associated with low HRV, we also assessed whether the presence of hypertension further reduced HRV in RA. METHODS: In RA-normotensive (n=13), RA-HTN (n=17), normotensive controls (NC; n=17) and HTN (n=16) controls, blood pressure and heart rate were recorded...
September 13, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28927747/astrocyte-elevated-gene-1-promotes-inflammation-and-invasion-of-fibroblast-like-synoviocytes-in-rheumatoid-arthritis
#13
Ruilong Hong, Kun Wang, Hongguang Shi
Astrocyte elevated gene-1 (AEG-1) was initially induced by HIV-1 infection and involved in tumor progression, migration and invasion as a nuclear factor-κB (NF-κB)-dependent gene. The present study we intended to investigate the protein expression of AEG-1 significantly associated with rheumatoid arthritis. Western blot analysis and immunohistochemistry demonstrated that AEG-1 was upregulated in synovial tissue of RA patients compared with the controls. Double immunofluorescent staining suggested that AEG-1 was expressed in fibroblast-like synoviocytes (FLS) of RA patients...
September 13, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28927738/dmard-use-is-associated-with-a-higher-risk-of-dementia-in-patients-with-rheumatoid-arthritis-a-propensity-score-matched-case-control-study
#14
Ming-Hsien Chou, Jong-Yi Wang, Cheng-Li Lin, Wei-Sheng Chung
BACKGROUND: Patients with rheumatoid arthritis (RA) exhibit an increased risk of dementia. Disease-modifying antirheumatic drugs (DMARDs) are commonly used to slow RA progression, but studies investigating the relationship between DMARDs and dementia in patients with RA are lacking. We investigated the relationship between DMARDs and dementia in patients with RA. METHODS: Using the National Health Insurance Research Database, patients aged ≥20years, who were newly diagnosed with RA between 2000 and 2011 were identified...
September 16, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28927315/systematic-review-and-meta-analysis-of-the-epidemiology-of-polyautoimmunity-in-sj%C3%A3-gren-s-syndrome-secondary-sj%C3%A3-gren-s-syndrome-focusing-on-autoimmune-rheumatic-diseases
#15
H Alani, J R Henty, N L Thompson, E Jury, C Ciurtin
OBJECTIVE: The epidemiology of polyautoimmunity in Sjögren's syndrome (secondary Sjögren's syndrome - sSS) is not well defined and has not been investigated before using a systematic approach. We conducted a systematic review of the epidemiology of sSS associated with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), scleroderma, and myositis, assessing the prevalence rates (PRs) and clinical and serological features of sSS. METHOD: A systematic literature search of PubMed and Embase databases (updated to March 2016) was performed to identify all published data on PR, demographic profile, clinical manifestations, laboratory features, and causes of death associated with sSS...
September 20, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28926469/a-survey-of-glucocorticoid-adverse-effects-and-benefits-in-rheumatic-diseases-the-patient-perspective
#16
Rachel J Black, Susan M Goodman, Carlee Ruediger, Susan Lester, Sarah L Mackie, Catherine L Hill
OBJECTIVE: The aim of this study was to explore, from the patient's perspective, the beneficial and adverse effects (AEs) of glucocorticoids (GCs) in patients with rheumatic diseases, to be used in the development of a patient-reported outcome measure. METHODS: A cross-sectional survey, capturing benefits and AEs of GC use, was administered to 2 groups of patients: (1) those attending a tertiary rheumatology clinic with various rheumatic diseases who had used GCs within the past year and (2) patients from the Hospital for Special Surgery rheumatoid arthritis database...
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28926459/disseminated-cutaneous-herpes-in-a-patient-with-rheumatoid-arthritis
#17
Melissa Nobrega Vasques de Freitas, Mariana Ortega Perez, Thaís Carvalho Barboza, Maria Lourdes Peris Barbo
No abstract text is available yet for this article.
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28926381/total-elbow-arthroplasty-for-distal-humeral-fractures-a-ten-year-minimum-follow-up-study
#18
Raul Barco, Philipp N Streubel, Bernard F Morrey, Joaquin Sanchez-Sotelo
BACKGROUND: Total elbow arthroplasty is commonly considered for elderly patients with comminuted distal humeral fractures. Satisfactory short-term outcomes have been reported, but long-term outcomes are unknown. Our purpose was to assess the long-term outcomes of total elbow arthroplasty after distal humeral fracture and to determine differences between elbows with or without inflammatory arthritis at the time of fracture. METHODS: Forty-four total elbow arthroplasties were performed after distal humeral fracture; those patients were followed for a minimum of 10 years and were evaluated with regard to pain, motion, Mayo Elbow Performance Scores, complications, and reoperations...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28926162/retinal-vessel-morphology-in-rheumatoid-arthritis-association-with-systemic-inflammation-subclinical-atherosclerosis-and-cardiovascular-risk
#19
Panagiota Anyfanti, Areti Triantafyllou, Eugenia Gkaliagkousi, Nikolaos Koletsos, Georgios Athanasopoulos, Xenophon Zabulis, Vasiliki Galanopoulou, Spyros Aslanidis, Stella Douma
OBJECTIVE: Quantification of retinal vessel morphology has emerged as a marker of cardiovascular health. We examined retinal microvascular diameters in RA, particularly in regard with systemic inflammation, subclinical atherosclerosis and cardiovascular risk. METHODS: Retinal images from RA patients and controls were processed using computerized software, to obtain central retinal arteriolar (CRAE) and venular (CRVE) equivalent and arteriovenous ratio (AVR). Subclinical atherosclerosis was assessed with carotid intima-media thickness (cIMT), and 10-year risk of general cardiovascular disease was calculated...
September 19, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28925718/interaction-analysis-between-blk-rs13277113-polymorphism-and-bank1-rs3733197-polymorphism-mmel1-tnfrsf14-rs3890745-polymorphism-in-determining-susceptibility-to-rheumatoid-arthritis
#20
Hua Huang, Si-Chao Huang, Dong-Jin Hua, Qing-Qing Sun, Han Cen, Xia-Fei Xin
Two pairwise genetic interactions (B cell lymphocyte kinase (BLK) rs13277113,B cell scaffold protein with ankyrin repeats 1 (BANK1) rs3733197and BLK rs13277113 membrane metalloendopeptidase like 1 (MMEL1)/ tumor necrosis factor receptor superfamily member 14 (TNFRSF14) rs3890745) have been demonstrated in determining susceptibility to rheumatoid arthritis (RA) without replication, thus this study was performed to examine whether abovementioned genetic polymorphisms were associated with RA and further tests were performed to see whether aforementioned genetic interactions existed in RA among Chinese population...
September 19, 2017: Autoimmunity
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