keyword
MENU ▼
Read by QxMD icon Read
search

Peptic ulcers

keyword
https://www.readbyqxmd.com/read/28644872/helicobacter-pylori-gene-silencing-in-vivo-demonstrates-urease-is-essential-for-chronic-infection
#1
Aleksandra W Debowski, Senta M Walton, Eng-Guan Chua, Alfred Chin-Yen Tay, Tingting Liao, Binit Lamichhane, Robyn Himbeck, Keith A Stubbs, Barry J Marshall, Alma Fulurija, Mohammed Benghezal
Helicobacter pylori infection causes chronic active gastritis that after many years of infection can develop into peptic ulceration or gastric adenocarcinoma. The bacterium is highly adapted to surviving in the gastric environment and a key adaptation is the virulence factor urease. Although widely postulated, the requirement of urease expression for persistent infection has not been elucidated experimentally as conventional urease knockout mutants are incapable of colonization. To overcome this constraint, conditional H...
June 23, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28642748/helicobacter-hygiene-atopy-and-asthma
#2
REVIEW
Muhammad Miftahussurur, Iswan A Nusi, David Y Graham, Yoshio Yamaoka
The hygiene hypothesis links environmental and microbial exposures in early life to the prevalence of atopy, allergy, and asthma. Helicobacter pylori infection is typically acquired in childhood and acquisition of the infection is associated with poor household hygiene. Some population surveys have shown an inverse association between H. pylori infection and atopy, allergy, and asthma leading to the suggestion that H. pylori infection may be protective against disease; others consider it simply a biomarker for poor household hygiene...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28642210/rationale-and-design-for-a-randomized-comparison-of-efficacy-and-safety-between-aspirin-and-clopidogrel-in-atrial-fibrillation-patients-with-low-stroke-risk-cesac-af-trial
#3
Sang Min Park, Haemin Jeong, Mi-Hyang Jung, Kyung Soon Hong, Myeong-Ki Hong, Chang Seok Bang, Christopher Y Kim
BACKGROUND: Atrial fibrillation (AF) increases the risk of thromboembolic stroke. An oral anticoagulant should be administrated to prevent stroke in patients with moderate stroke risk (ie, CHA2DS2-VASc score>2). If the stroke risk is low (i.e. the score=1), however, antiplatelet agent such as aspirin is widely used. Aspirin can cause peptic ulcer disease (PUD) while its alternative, clopidogrel, theoretically does not. OBJECTIVE: To elucidate the efficacy and safety between aspirin and clopidogrel, a multicenter randomized controlled trial was designed in AF patients with low stroke risk...
June 19, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28638885/anti-ulcerogenic-efficacy-and-mechanisms-of-edible-and-natural-ingredients-in-nsaid-induced-animal-models
#4
Weiping Bi, Lizhi Hu, Mao-Qiang Man
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain disorders. Some people use NSAIDs on daily basis for preventive purpose. But a variety of severe side effects can be induced by NSAIDs. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. This paper reviews the efficacy and safety of edible natural ingredients in preventing the development of gastric ulcer induced by NSAIDs in animal models...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28638589/gastrocolic-fistula-presented-as-an-early-complication-of-gastric-surgery-in-a-42-year-old-man
#5
Mohammad Javad Zahedi, Sara Shafiei Pour, Masood Dehghani, Nazanin Eslami
Currently, surgery is less needed for the treatment of refractory peptic ulcer disease (PUD) or its complications. So, the complications of PUD surgery have been clearly declined. Here in, we present a 42-year-old man with chronic watery diarrhea and significant weight loss during 2 years after gastrojejunostomy for the treatment of obstructive PUD. Small bowel gastrointestinal series showed rapid transit without passage of contrast in the parts of small bowel. The patient was scheduled for exploratory laparotomy...
April 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28636163/the-pu-prom-a-patient-reported-outcome-measure-for-peptic-ulcer-disease
#6
Na Liu, Jing Lv, Jinchun Liu, Yanbo Zhang
OBJECTIVE: Patient-reported outcome measure (PROM) conceived to enable description of treatment-related effects, from the patient perspective, bring the potential to improve in clinical research, and to provide patients with accurate information. Therefore, the aim of this study was to develop a patient-centred peptic ulcer patient-reported outcome measure (PU-PROM) and evaluate its reliability, validity, differential item functioning (DIF) and feasibility. METHOD: To develop a conceptual framework and item pool for the PU-PROM, we performed a literature review and consulted other measures created in China and other countries...
June 21, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28625138/membrane-bound-atp-dependent-energy-systems-as-extra-and-intracellular-key-signals-for-gastrointestinal-functions-and-their-regulations-in-the-gastrointestinal-mucosa
#7
Gyula Mózsik, Imre László Szabó, József Czimmer
AIMS: Our research group has carried out various biochemical examinations in rat gastric ulcer models and in human gastrointestinal resecates obtained from patient who underwent gastric intervention due to peptic ulcer disease. Biochemical methods gave excellent possibility to approach the biochemical events taking place in tissues, cellular and subcellular regulatory levels during of ulcer development and of its prevetions. This paper gives a briefsummary of these biochemical examinations conducted during this study period started from the 1960's up till now...
June 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28616396/management-for-non-variceal-upper-gastrointestinal-bleeding-in-elderly-patients-the-experience-of-a-tertiary-university-hospital
#8
Koichiro Kawaguchi, Hiroki Kurumi, Yohei Takeda, Kazuo Yashima, Hajime Isomoto
BACKGROUND: Peptic ulcer bleeding (PUB) is the main cause of non-variceal upper gastrointestinal bleeding (UGIB). Endoscopic treatment and acid suppression with proton-pump inhibitors (PPIs) are most important in the management of PUB and these treatments have reduced mortality. However, elderly patients sometimes have a poor prognostic outcome due to severe comorbidities. METHODS: A retrospective study was performed on 504 cases with acute non-variceal UGIB who were examined in our hospital, in order to reveal the risk factor of a poor outcome in elderly patients...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28606845/effects-of-community-screening-for-helicobacter-pylori-13-year-follow-up-of-a-randomized-controlled-trial-hep-fyn
#9
Maria Bomme Høgh, Jane Møller Hansen, Mette Wildner-Christensen, Jesper Hallas, Ove B Schaffalitzky de Muckadell
BACKGROUND & AIMS: Helicobacter pylori (Hp) eradication improves the prognosis of peptic ulcer disease (PUD), dyspepsia, and possibly gastric cancer. Hp screening tests are accurate and eradication therapy is effective. Hp population screening seems attractive. The aim of this study was to evaluate the long-term effect of Hp population screening and eradication on dyspepsia prevalence and the incidence of PUD, and as secondary outcomes to assess the effect on health-care consumption and quality of life...
June 9, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28592787/rare-gastric-lesions-associated-with-helicobacter-pylori-infection-a-histopathological-review
#10
Mee Joo
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. However, some rare gastric lesions exhibiting distinctive histological features may also be associated with H. pylori infection, including lymphocytic gastritis, granulomatous gastritis, Russell body gastritis, or crystal-storing histiocytosis. Although diverse factors can contribute to their development, there is convincing evidence that H. pylori infection may play a pathogenic role...
June 5, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28584503/surgical-scales-primary-closure-versus-gastric-resection-for-perforated-gastric-ulcer-a-surgical-debate
#11
REVIEW
Mahir Gachabayov, Valentin Babyshin, Oleg Durymanov, Dmitriy Neronov
Perforated gastric ulcer is one of the most life-threatening complications of peptic ulcer disease with high morbidity and mortality rates. The surgical strategy for gastric perforation in contrast with duodenal perforations often requires consilium and intraoperative debates. The subject of the debate is a 59-year-old male patient who presented with perforated giant gastric ulcer complicated by generalized peritonitis and severe sepsis. The debate is based on a systematized table dividing all factors into three groups and putting them on surgical scales...
January 2017: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/28577915/histo-blood-group-carbohydrates-as-facilitators-for-infection-by-helicobacter-pylori
#12
REVIEW
Cinara Cássia Brandão de Mattos, Luiz Carlos de Mattos
Helicobacter pylori infect millions of people around the world. It occupies a niche in the human gastrointestinal tract characterized by high expression of a repertoire of carbohydrates. ABO and Lewis histo-blood group systems are controlled by genes coding for functional glycosyltransferases which synthesize great diversity of related fucosylated carbohydrate in different tissues, including gastrointestinal mucosa, and exocrine secretions. The structural diversity of histo-blood group carbohydrates is highly complex and depends on epistatic interactions among gene-encoding glycosyltransferases...
May 31, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28576278/spectroscopic-characterization-and-fluorescence-imaging-of-helicobacter-pylori-endogenous-porphyrins
#13
Antonella Battisti, Paola Morici, Francesco Ghetti, Antonella Sgarbossa
Conventional antimicrobial strategies have become increasingly ineffective due to the rapid emergence of antibiotic resistance among pathogenic bacteria. In order to overcome this problem, antimicrobial PhotoDynamic Therapy (PDT) is considered a promising alternative therapy. PDT has a broad spectrum of action and low mutagenic potential. It is particularly effective when microorganisms present endogenous photosensitizing pigments. Helicobacter pylori (Hp), a pathogen notoriously responsible of severe gastric infections (chronic gastritis, peptic ulcer, MALT lymphoma and gastric adenocarcinoma), produces and accumulates the photosensitizers protoporphyrin IX and coproporphyrin, thus it might be a suitable target of antimicrobial PDT...
May 26, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28574381/-measurement-of-histones-and-circulating-extracellular-nucleic-acids-in-patients-with-complicated-forms-of-peptic-ulcer
#14
G Yerznkyan, B Kultanov, K Shakeev, Ye Tatina
We studied 135 people (24 people, apparently healthy, 39 uncomplicated peptic ulcer disease, 42 people with complex forms peptic ulcer, 30 and after the treatment of complicated forms of peptic ulcer disease, both sexes (18-45 y.). In all patients, the diagnosis was confirmed fibrogastroduodenoscopy (EGD). Determination of histones and acid soluble fraction (ASF), RNA, DNA, in blood was performed by the method of L. Markusheva. Studies have led to the conclusion that the change in the blood concentration of extracellular nucleic acids in patients with uncomplicated disease and complex shapes can be caused by oxidative stress products and can be a signal for elimination of nucleic acids from cells...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28571523/association-of-heterogenicity-of-helicobacter-pylori-cag-pathogenicity-island-with-peptic-ulcer-diseases-and-gastric-cancer
#15
J Khatoon, K N Prasad, R Prakash Rai, U C Ghoshal, N Krishnani
OBJECTIVE: To investigate the frequency and integrity of certain cag pathogenicity island genes (cagPAI) in Helicobacter pylori strains and their association with peptic ulcer disease (PUD) and gastric cancer. MATERIAL AND METHODS: We enrolled 240 adult patients [120 with functional dyspepsia (FD), 50 with PUD and 70 with gastric cancer] undergoing upper gastrointestinal endoscopy. H. pylori infection was diagnosed when either culture or any two of the three tests (rapid urease test, histopathology and specific ureA PCR) were positive...
June 2, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28565788/immunosuppressive-agents-are-associated-with-peptic-ulcer-bleeding
#16
Minoru Tomizawa, Fuminobu Shinozaki, Rumiko Hasegawa, Yoshinori Shirai, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige
Peptic ulcer bleeding can be fatal. Non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppressive agents are administered for long-term usage. The present study assessed the association between peptic ulcer bleeding and administration of NSAIDs, corticosteroids and immunosuppressive agents. Furthermore, the efficacy of lowering the risk of peptic ulcer bleeding with proton pump inhibitors (PPI) and histamine 2 receptor antagonists (H2RA) was evaluated. Medical records were retrospectively analyzed for patients subjected to an upper gastrointestinal (GI) endoscopy performed at the National Hospital Organization Shimoshizu Hospital (Yotsukaido, Japan) from October 2014 to September 2015...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28564642/effectiveness-of-endoscopic-hemostasis-with-soft-coagulation-for-non-variceal-upper-gastrointestinal-bleeding-over-a-12-year-period
#17
Daisuke Yamaguchi, Yasuhisa Sakata, Hisako Yoshida, Naoko E Furukawa, Nanae Tsuruoka, Toru Higuchi, Akira Watanabe, Ryo Shimoda, Seiji Tsunada, Ryuichi Iwakiri, Kazuma Fujimoto
BACKGROUND/AIMS: In this study, investigations were carried out to ascertain whether soft coagulation hemostasis for non-variceal upper gastrointestinal bleeding (UGIB) has ever been performed in a time-dependent manner. METHODS: Medical records of 502 patients who had undergone emergency endoscopic hemostasis for non-variceal UGIB from 2003 to 2014 were checked and the modalities were used to achieve hemostasis compared between the first period from 2003 to 2008 (197 patients) and the second period from 2009 to 2014 (305 patients)...
June 1, 2017: Digestion
https://www.readbyqxmd.com/read/28558695/azithromycin-and-risk-of-copd-exacerbations-in-patients-with-and-without-helicobacter-pylori
#18
Seung Won Ra, Marc A Sze, Eun Chong Lee, Sheena Tam, Yeni Oh, Nick Fishbane, Gerard J Criner, Prescott G Woodruff, Stephen C Lazarus, Richard Albert, John E Connett, Meilan K Han, Fernando J Martinez, Shawn D Aaron, Robert M Reed, S F Paul Man, Don D Sin
BACKGROUND: Helicobacter pylori (HP) infection is associated with reduced lung function and systemic inflammation in chronic obstructive pulmonary disease (COPD) patients. Azithromycin (AZ) is active against HP and reduces the risk of COPD exacerbation. We determined whether HP infection status modifies the effects of AZ in COPD patients. METHODS: Plasma samples from 1018 subjects with COPD who participated in the Macrolide Azithromycin (MACRO) in COPD Study were used to determine the HP infection status at baseline and 12 months of follow-up using a serologic assay...
May 30, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28555193/helicobacter-pylori-from-peptic-ulcer-patients-in-uganda-is-highly-resistant-to-clarithromycin-and-fluoroquinolones-results-of-the-genotype-helicodr-test-directly-applied-on-stool
#19
Denish Calmax Angol, Ponsiano Ocama, Tess Ayazika Kirabo, Alfred Okeng, Irene Najjingo, Freddie Bwanga
BACKGROUND: Around 70-90% of peptic ulcer disease (PUD) is due to Helicobacter pylori and requires treatment with antimicrobials to which these bacteria are susceptible. Common H. pylori diagnostic tests do not provide drug susceptibility data. Using the GenoType HelicoDR PCR test designed for gastric biopsies for simultaneous detection of H. pylori and its resistance to clarithromycin (CLA)/fluoroquinolones (FLQ), we present evidence for stool as an optional test specimen and also provide data on prevalence of H...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28546954/pleiotropic-cytotoxicity-of-vaca-toxin-in-host-cells-and-its-impact-on-immunotherapy
#20
REVIEW
Farnaz Fahimi, Mohammad Reza Tohidkia, Mehdi Fouladi, Reza Aghabeygi, Naser Samadi, Yadollah Omidi
Introduction: In the recent decades, a number of studies have highlighted the importance of Helicobacter pylori in the initiation and development of peptic ulcer and gastric cancer. Some potential virulence factors (e.g., urease, CagA, VacA, BabA) are exploited by this microorganism, facilitating its persistence through evading human defense mechanisms. Among these toxins and enzymes, vacuolating toxin A (VacA) is of a great importance in the pathogenesis of H. pylori. VacA toxin shows different pattern of cytotoxicity through binding to different cell surface receptors in various cells...
2017: BioImpacts: BI
keyword
keyword
67998
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"