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https://www.readbyqxmd.com/read/29788876/exploiting-significance-of-physical-exercise-in-prevention-of-gastrointestinal-disorders
#1
Jan Bilski, Agnieszka Mazur-Bialy, Marcin Magierowski, Slawomir Kwiecien, Dagmara Wojcik, Agata Ptak-Belowska, Marcin Surmiak, Aneta Targosz, Katarzyna Magierowska, Tomasz Brzozowski
BACKGROUND: Physical activity can be involved in the prevention of gastrointestinal (GI)-tract diseases, however, the results regarding the volume and the intensity of exercise considered as beneficial for protection of gastrointestinal organs are conflicting. AIMS AND METHODS: The main objective of this review is to provide a comprehensive and updated overview on the beneficial and harmful effects of physical activity on the gastrointestinal tract. We attempted to discuss recent evidence regarding the association between different modes and intensity levels of exercise and physiological functions of the gut and gut pathology...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29786579/operative-treatment-of-corrosive-esophageal-strictures
#2
Volodymyr O Shaprynskyi, Yevhen V Shaprynskyi, Yaroslav V Karyi, Serhii A Lysenko, Oleg O Vorovskyi, Andrii I Semenenko
OBJECTIVE: Introduction: Nowadays operative treatment of corrosive esophageal strictures remains one of the difficult and unsolved problems in surgery. The level of postoperative complications such as anastomotic leak (develops in 7-30% of cases), infections, pneumonia, pleural empyema, mediastinitis, peritonitis, postoperative corrosive strictures is still rather high. The aim of our work was to improve the results of surgical treatment of patients with corrosive esophageal strictures by analyzing and refining on conservative therapy options as well as differentiated approach to each operative treatment method...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29785564/helicobacter-pylori-infection-in-pediatric-patients-update-on-diagnosis-and-eradication-strategies
#3
REVIEW
Kallirroi Kotilea, Nicolas Kalach, Matjaž Homan, Patrick Bontems
Helicobacter pylori infection is acquired mainly in childhood and remains an essential cause of peptic ulcer disease and gastric cancer. This article provides commentary on the last ESPGHAN/NASPGHAN guidelines and on publications made after the consensus conference of 2015. The majority of infected children are asymptomatic and pediatric studies do not support a role for H. pylori in functional disorders such as recurrent abdominal pain. The role of H. pylori infection in failure to thrive, children's growth, type I diabetes mellitus (T1DM), and celiac disease remains controversial...
May 22, 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29783236/clinical-aspects-of-gastropathy-development-in-patients-with-chronic-obstructive-pulmonary-disease
#4
Anna V Chetaikina, Helen Ye Sklyarova, Iryna V Shalko, Roman Ya Dutka
OBJECTIVE: Introduction: Chronic obstructive pulmonary disease (COPD) is a one of the main reasons of disability and mortality in the world. The essential attention is dedicated to the combination of COPD and erosive/ulcer defects with the haemorrhage risk factor. The aim was to compare gastric acidity and mucoid secretion in patients with chronic obstructive pulmonary disease of gastropathy development. PATIENTS AND METHODS: Materials and methods: 94 patients with gastroduodenal erosive and ulcerous defects combined with COPD were examined...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29780000/the-effects-of-proton-pump-inhibitor-on-hepatic-vascular-responsiveness-and-hemodynamics-in-cirrhotic-rats
#5
I-Fang Hsin, Shao-Jung Hsu, Chiao-Lin Chuang, Teh-Ia Huo, Hui-Chun Huang, Fa-Yauh Lee, Hsin-Ling Ho, Shu-Yu Chang, Shou-Dong Lee
BACKGROUND: Liver cirrhosis is associated with increased intrahepatic resistance due to hepatic fibrosis and exaggerated vasoconstriction. Recent studies have indicated that proton pump inhibitors (PPIs), in addition to acid suppression, modulate vasoactive substances and vasoresponsiveness. PPIs are frequently prescribed in patients with cirrhosis due to a higher prevalence of peptic ulcers, however other impacts are unknown. METHODS: Liver cirrhosis was induced in Sprague-Dawley rats with common bile duct ligation (BDL)...
May 17, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29779861/hopq-impacts-the-integrin-%C3%AE-5%C3%AE-1-independent-nf-%C3%AE%C2%BAb-activation-by-helicobacter-pylori-in-ceacam-expressing-cells
#6
Michael Hartmut Feige, Olga Sokolova, Anna Pickenhahn, Gunter Maubach, Michael Naumann
Helicobacter pylori infection persists in more than half of the world's population and represents a risk factor for peptic ulcer disease and gastric cancer. Virulent strains of H. pylori carry a cag pathogenicity island (cagPAI), which encodes a type IV secretion system (T4SS) with the capability to inject the effector protein cytotoxin-associated gene A (CagA) into eukaryotic cells. Colonisation of the gastric epithelium by H. pylori provokes direct activation of the proinflammatory and survival factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)...
May 14, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29778548/risk-factors-of-the-peptic-ulcer-bleeding-in-aging-uremia-patients-under-regular-hemodialysis
#7
Xi-Hsuan Lin, Chung-Chi Lin, Yuan-Jen Wang, Jiing-Chyuan Luo, Shih-Hao Young, Ping-Hsien Chen, Ming-Chih Hou, Fa-Yauh Lee
BACKGROUND: Previous studies have shown that uremia patients under hemodialysis (HD) have a significantly higher occurrence of peptic ulcer bleeding (PUB) than healthy controls and that elderly patients remain at high risk of peptic ulcer disease (PUD) and PUB. Here we aimed to identify the risk factors for PUB in aging (≥65-years-old) uremic patients under regular HD. METHODS: Using data from the National Health Insurance Research Database of Taiwan, we compared 18,252 aging regular HD patients and 17,883 age-, gender-, and medication-matched patients without kidney disease (control group)...
May 16, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29771269/upper-gastrointestinal-alterations-in-kidney-transplant-candidates
#8
João Pedro Homse Netto, João Pedro Sant'Anna Pinheiro, Mariana Lopes Ferrari, Mirella Tizziani Soares, Rogério Augusto Gomes Silveira, Mariana Espiga Maioli, Vinicius Daher Alvares Delfino
INTRODUCTION: The incidence of gastrointestinal disorders among patients with chronic kidney disease (CKD) is high, despite the lack of a good correlation between endoscopic findings and symptoms. Many services thus perform upper gastrointestinal (UGI) endoscopy on kidney transplant candidates. OBJECTIVES: This study aims to describe the alterations seen on the upper endoscopies of 96 kidney-transplant candidates seen from 2014 to 2015. METHODS: Ninety-six CKD patients underwent upper endoscopic examination as part of the preparation to receive kidney grafts...
May 14, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29770238/charlson-comorbidity-index-as-a-predictor-of-periodontal-disease-in-elderly-participants
#9
Jae-Hong Lee, Jung-Kyu Choi, Seong-Nyum Jeong, Seong-Ho Choi
Purpose: This study investigated the validity of the Charlson comorbidity index (CCI) as a predictor of periodontal disease (PD) over a 12-year period. Methods: Nationwide representative samples of 149,785 adults aged ≥60 years with PD (International Classification of Disease, 10th revision [ICD-10], K052-K056) were derived from the National Health Insurance Service-Elderly Cohort during 2002-2013. The degree of comorbidity was measured using the CCI (grade 0-6), including 17 diseases weighted on the basis of their association with mortality, and data were analyzed using multivariate Cox proportional-hazards regression in order to investigate the associations of comorbid diseases (CDs) with PD...
April 2018: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29764950/cagy-dependent-regulation-of-type-iv-secretion-in-helicobacter-pylori-is-associated-with-alterations-in-integrin-binding
#10
Emma C Skoog, Vasilios A Morikis, Miriam E Martin, Greg A Foster, Lucy P Cai, Lori M Hansen, Beibei Li, Jennifer A Gaddy, Scott I Simon, Jay V Solnick
Strains of Helicobacter pylori that cause ulcer or gastric cancer typically express a type IV secretion system (T4SS) encoded by the cag pathogenicity island ( cag PAI). CagY is an ortholog of VirB10 that, unlike other VirB10 orthologs, has a large middle repeat region (MRR) with extensive repetitive sequence motifs, which undergo CD4+ T cell-dependent recombination during infection of mice. Recombination in the CagY MRR reduces T4SS function, diminishes the host inflammatory response, and enables the bacteria to colonize at a higher density...
May 15, 2018: MBio
https://www.readbyqxmd.com/read/29755012/association-of-a-single-nucleotide-polymorphism-in-the-tlr2-gene-rs3804099-but-not-in-the-tlr4-gene-rs4986790-with-helicobacter-pylori-infection-and-peptic-ulcer
#11
Ehsan Mirkamandar, Maryam Nemati, Mohammad Mehdi Hayatbakhsh, Arezu Bassagh, Arezu Khosravimashizi, Abdollah Jafarzadeh
BACKGROUND/AIMS: Toll-like receptors (TLRs), particularly TLR2 and TLR4, take part in elicitation of immune responses against Helicobacter pylori (H. pylori). This study aimed to investigate the relationship between single nucleotide polymorphisms (SNP) rs3804099 in the TLR2 gene and rs4986790 in the TLR4 gene with H. pylori infection and peptic ulcer (PU). MATERIALS AND METHODS: Blood specimens were obtained from 350 individuals, including 100 H. pylori-infected patients with PU, 125 H...
May 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29746564/multiple-bacterial-infections-increase-the-risk-of-hepatic-encephalopathy-in-patients-with-cirrhosis
#12
Lan-Ting Yuan, Seng-Kee Chuah, Shih-Cheng Yang, Chih-Ming Liang, Cheng-Kun Wu, Wei-Chen Tai, Tsung-Hsing Hung, Seng-Howe Nguang, Jiunn-Wei Wang, Kuo-Lun Tseng, Ming-Kun Ku, Pin-I Hsu, Deng-Chyang Wu, Chien-Ning Hsu
OBJECTIVE: Patients with liver cirrhosis (LC) are at increased risk for bacterial infections. It is not fully understood how exposure to infections induces further development of hepatic encephalopathy (HE). This study estimated risks of infection associated with HE among patients with LC. METHODS: A nested case-control study of 14,428 adult patients with LC was performed using the population-based Longitudinal Health Insurance Database 2000 in Taiwan. Cases were cirrhotic patients who developed HE during follow-up...
2018: PloS One
https://www.readbyqxmd.com/read/29745474/laparoscopic-total-gastrectomy-for-remnant-gastric-cancer-a-single-institution-experience
#13
Eisuke Booka, Masaki Kaihara, Koki Mihara, Shin Nishiya, Kan Handa, Yasuhiro Ito, Shintaro Shibutani, Tomohisa Egawa, Atsushi Nagashima
INTRODUCTION: The incidence of remnant gastric cancer is increasing because of past use of subtotal gastrectomy to treat peptic ulcer and increased survival rates after radical gastrectomy for gastric cancer. The feasibility and advantages of laparoscopic total gastrectomy (LTG) for remnant gastric cancer remain unclear. Therefore, we aimed to investigate the safety, feasibility, and clinical short-term outcomes of LTG for remnant gastric cancer. METHODS: Patients who underwent completion total gastrectomy for remnant gastric cancer between April 2007 and October 2017 were divided into two groups: the open total gastrectomy (OTG) group and the LTG group...
May 10, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29745325/life-style-and-peptic-ulcer-disease
#14
Berrak C Yegen
The risk of developing peptic ulcer disease (PUD) was shown to be associated with genetic inheritance, life-style and social status of the patients. Unhealthy lifestyle habits and failure in coping with stress have been closely associated with the occurrence of PUD. In contrary, limiting the use of analgesic drugs and glucocorticoids, controlling environmental and socioeconomic factors that predispose to H. Pylori infection, having a balanced diet, exercising regularly, coping successfully with stress, avoiding smoking, limiting alcohol intake and getting sufficient night sleep are essential in prevention and healing of PUD...
May 9, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29735759/measurement-of-internal-ph-in-helicobacter-pylori-by-using-green-fluorescent-protein-fluorimetry
#15
Yi Wen, David R Scott, Olga Vagin, Elmira Tokhtaeva, Elizabeth A Marcus, George Sachs
Helicobacter pylori is an organism known to colonize the normal human stomach. Previous studies have shown that the bacterium does this by elevating its periplasmic pH via the hydrolysis of urea. However, the value of the periplasmic pH was calculated indirectly from the proton motive force equation. To measure the periplasmic pH directly in H. pylori , we fused EGFP to the predicted twin arginine-signal peptides of HydA and KapA from H. pylori , and TorA from E. coli The fusion proteins were expressed in the H...
May 7, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29734656/association-between-peptic-ulcer-disease-and-periodontitis-a-nationwide-population-based-case-control-study-in-taiwan
#16
Hui-Chieh Yu, Tsung-Po Chen, Chia-Yi Wei, Yu-Chao Chang
Previous studies have suggested that peptic ulcer disease (PUD) including stomach and duodenal ulcers might be associated with periodontitis (PD); however, no clear conclusions have been reached thus far. In this retrospective case-control study, we aimed to investigate the association between PUD and PD by using a large population-based dataset in Taiwan. A population-based retrospective case control study was conducted using the Longitudinal Health Insurance Database 2010 (LHID2010) derived from the National Health Insurance Research database (NHIRD) in Taiwan from 2000 to 2013...
May 4, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29726621/elder-abuse-and-its-medical-outcomes-in-older-chinese-people-with-cognitive-and-physical-impairments
#17
REVIEW
Boye Fang, Elsie Yan, Ko Ling Chan, Partick Ip
OBJECTIVES: Elder abuse poses a major public health threat considering the ongoing rapid aging of the global population. This study investigates the association between elder abuse by family caregivers and medical outcomes among older Chinese patients with cognitive and physical impairments in the People's Republic of China. METHODS: Using cross-sectional design, 1002 older patients (aged 55 y and older) and their family caregivers were recruited from 3 grade A hospitals in Guangdong Province...
May 4, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29724988/total-gastric-necrosis-due-to-mucormycosis-a-rare-case-of-gastric-perforation
#18
Salah Termos, Feras Othman, Mohammad Alali, Bader M S Al Bader, Talal Alkhadher, Wael Fathi Hassanaiah, Ali Taqi, Abhijit Sapkal
BACKGROUND Spontaneous gastric perforation is usually a complication of peptic ulcer disease, or a postoperative complication resulting from gastric torsion. Mucormycosis (or zygomycosis) is an uncommon opportunistic fungal infection that is usually seen in immunocompromised patients and is associated with significant morbidity and mortality. This report is of a rare case of spontaneous gastric perforation due to mucormycosis infection. CASE REPORT A 52-year-old woman, with a past medical history of heroin abuse, diabetes mellitus, hypertension, and chronic kidney disease treated by dialysis, presented to the emergency department with cellulitis of the arms...
May 4, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29724386/comorbidities-and-risk-of-mortality-among-hospitalized-patients-with-idiopathic-pulmonary-fibrosis-in-spain-from-2002-to-2014
#19
Fernando Pedraza-Serrano, Rodrigo Jiménez-García, Ana López-de-Andrés, Valentín Hernández-Barrera, Jesús Esteban-Hernández, Gema Sánchez-Muñoz, Luis Puente-Maestu, Javier de-Miguel-Díez
BACKGROUND: To describe and compare the comorbid conditions, the in-hospital mortality (IHM) and the length of hospital stay (LOHS) among idiopathic pulmonary fibrosis (IPF) patients and non-IPF-matched patients hospitalized in Spain. We assess the performance of the Charlson Comorbidity Index[CCI] and the Elixhauser Comorbidity Index[ECI] to predict IHM in IPF and we identify the specific predictive factors of IHM in patients suffering IPF. METHODS: We identified patients with IPF hospitalized in years 2002, 2006, 2010 and 2014...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29722146/prevention-of-post-sphincterotomy-bleeding-by-proton-pump-inhibitor-a-randomized-controlled-trial
#20
Wai K Leung, David Yk But, S Y Wong, Teresa Sm Tong, Kevin Sh Liu, Ka-Shing Cheung, Simon Hy Tsang, Kenneth Sh Chok, Ronnie Tp Poon, Ivan Fn Hung
AIM: Post-sphincterotomy (EST) bleeding is one of the most frequent complications of endoscopic retrograde cholangiopancreatography (ERCP). Although the use of proton pump inhibitor (PPI) has been shown to reduce the risk of peptic ulcer bleeding, the role of PPI in preventing EST bleeding has not been evaluated. This study determined the role of pre-emptive PPI in patients undergoing EST. METHODS: It was an investigator-initiated open-label randomized study. Consecutive patients who were scheduled to have ERCP and EST were enrolled...
May 2, 2018: Journal of Digestive Diseases
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