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https://www.readbyqxmd.com/read/28422711/melatonin-exerts-anti-oral-cancer-effect-via-suppressing-lsd1-in-patient-derived-tumor-xenograft-models
#1
Cheng-Yu Yang, Chih-Kung Lin, Chang-Huei Tsao, Cheng-Chih Hsieh, Gu-Jiun Lin, Kuo-Hsing Ma, Yi-Shing Shieh, Huey-Kang Sytwu, Yuan-Wu Chen
Aberrant activation of histone lysine-specific demethylase (LSD1) increases tumorigenicity; hence, LSD1 is considered a therapeutic target for various human cancers. Although melatonin, an endogenously produced molecule, may defend against various cancers, the precise mechanism involved in its anti-oral cancer effect remains unclear. Patient-derived tumor xenograft (PDTX) models are preclinical models that can more accurately reflect human tumor biology compared with cell line xenograft models. Here, we evaluated the anticancer activity of melatonin by using LSD1-overexpressing oral cancer PDTX models...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418863/galnt14-genotype-as-a-response-predictor-for-concurrent-chemoradiotherapy-in-advanced-esophageal-squamous-cell-carcinoma
#2
Yung-Kuan Tsou, Kung-Hao Liang, Wey-Ran Lin, Hsien-Kun Chang, Chen-Kan Tseng, Chau-Ting Yeh
Esophageal squamous cell carcinoma is an aggressive cancer. We investigated genetic response predictors for patients with advanced esophageal squamous cell carcinoma receiving concurrent chemoradiotherapy. A cohort of 108 patients was recruited. Survival analysis showed that lower esophageal location of tumor, more advanced metastasis stage, and longer length of tumor were associated with poorer overall survival (adjusted P = 0.001, < 0.001, and 0.045, respectively), while the presence of complete/partial response to concurrent chemoradiotherapy was independently associated with better overall survival (adjusted P < 0...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28403855/quality-of-life-of-breast-and-cervical-cancer-survivors
#3
Huei-Ying Huang, Wen-Chen Tsai, Wen-Yu Chou, Yao-Ching Hung, Liang-Chih Liu, Kuo-Feng Huang, Wen-Ching Wang, Kam-Wing Leung, Ruey-Kuen Hsieh, Pei-Tseng Kung
BACKGROUND: Breast and cervical cancer are the most common cancers affecting women. The symptom distresses experienced by cancer survivors are critical factors influencing their quality of life (QOL). This study investigated the QOL of breast and cervical cancer survivors, their physical, psychological and social conditions. METHODS: The participants were older than 20 years, had been diagnosed with breast or cervical cancer for more than 2 years, and had completed their cancer treatment...
April 12, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28394261/folate-cycle-enzyme-mthfd1l-confers-metabolic-advantages-in-hepatocellular-carcinoma
#4
Derek Lee, Iris Ming-Jing Xu, David Kung-Chun Chiu, Robin Kit-Ho Lai, Aki Pui-Wah Tse, Lynna Lan Li, Cheuk-Ting Law, Felice Ho-Ching Tsang, Larry Lai Wei, Cerise Yuen-Ki Chan, Chun-Ming Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong
Cancer cells preferentially utilize glucose and glutamine, which provide macromolecules and antioxidants that sustain rapid cell division. Metabolic reprogramming in cancer drives an increased glycolytic rate that supports maximal production of these nutrients. The folate cycle, through transfer of a carbon unit between tetrahydrofolate and its derivatives in the cytoplasmic and mitochondrial compartments, produces other metabolites that are essential for cell growth, including nucleotides, methionine, and the antioxidant NADPH...
April 10, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28388649/influence-of-time-interval-from-diagnosis-to-treatment-on-survival-for-oral-cavity-cancer-a-nationwide-cohort-study
#5
Wen-Chen Tsai, Pei-Tseng Kung, Yueh-Hsin Wang, Kuang-Hua Huang, Shih-An Liu
OBJECTIVES: We aimed to explore the relationship between the time interval from diagnosis to treatment and survival of oral cavity squamous cell carcinoma patients. MATERIALS AND METHODS: A population-based study was conducted between 2004 and 2010. Claims data of oral squamous cell carcinoma patients were retrieved from the Taiwan Cancer Registry Database. Secondary data were obtained from Taiwan's National Health Insurance Research Database. RESULTS: A total of 21,263 patients were included in the final analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28364124/a-circulating-microrna-signature-capable-of-assessing-the-risk-of-hepatocellular-carcinoma-in-cirrhotic-patients
#6
Ya-Hui Huang, Kung-Hao Liang, Rong-Nan Chien, Tsung-Hui Hu, Kwang-Huei Lin, Chao-Wei Hsu, Chih-Lang Lin, Tai-Long Pan, Po-Yuan Ke, Chau-Ting Yeh
With the availability of potent antiviral therapies, complete suppression of hepatitis B virus (HBV) replication and total eradication of hepatitis C virus (HCV) can now be achieved. Despite these advances, hepatocellular carcinoma (HCC) still develops in a substantial proportion of cirrhotic patients, suggesting that host factors remain critical. Dysregulation of miRNAs is noted in many cancers, and circulating miRNAs can be readily assayed. In this study, we aimed to develop a circulating miRNA signature to assess the risk of HCC in cirrhotic patients...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28256535/rest-is-a-crucial-regulator-for-acquiring-emt-like-and-stemness-phenotypes-in-hormone-refractory-prostate-cancer
#7
Yi-Ting Chang, Tzu-Ping Lin, Mel Campbell, Chin-Chen Pan, Shu-Hui Lee, Hsin-Chen Lee, Muh-Hwa Yang, Hsing-Jien Kung, Pei-Ching Chang
Castration-resistance prostate cancer (CRPC), also known as hormone-refractory prostate cancer (HRPC), requires immediate attention since it is not only resistant to androgen ablation, chemo- and radiotherapy, but also highly metastatic. Increasing evidence suggests that enrichment of neuroendocrine (NE) cells is associated with CRPC. Here, combined RNA-seq and ChIP-seq analysis reveals that REST is involved in epithelial-mesenchymal transition (EMT) and stemness acquisition in NE differentiated prostate cancer (PCa) cells via direct transcriptional repression of Twist1 and CD44...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28254229/incidence-and-lifetime-risk-of-uterine-corpus-cancer-in-taiwanese-women-from-1991-to-2010
#8
Jerry Cheng-Yen Lai, Chia-Sui Weng, Sheng-Miauh Huang, Nicole Huang, Yiing-Jenq Chou, Chien-Chen Wang, Kung-Liahng Wang
OBJECTIVE: Although uterine corpus cancer has been the most common malignancy of the female genital tract in many countries, the lifetime risk of this cancer has not yet been determined among Taiwanese women. The purpose of the study was to describe the change in incidence and the lifetime risk of uterine corpus cancer over a 20-year period from 1991 to 2010 in Taiwan. MATERIALS AND METHODS: We conducted a population-based registry study using the released database (available online) from the Taiwan Cancer Registry...
February 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28235782/development-of-a-multiplexed-lc-mrm-ms-method-for-evaluation-of-salivary-proteins-as-oral-cancer-biomarkers
#9
Yi-Ting Chen, Hsiao-Wei Chen, Chun-Feng Wu, Lichieh Julie Chu, Wei-Fang Chiang, Chih-Ching Wu, Jau-Song Yu, Cheng-Han Tsai, Kung-Hao Liang, Yu-Sun Chang, Maureen Wu, Wei-Ting Ou Yang
Multiple (selected) reaction monitoring (MRM/SRM) of peptides is a growing technology for target protein quantification because it is more robust, precise, accurate, high-throughput, and multiplex-capable than antibody-based techniques. The technique has been applied clinically to the large-scale quantification of multiple target proteins in different types of fluids. However, previous MRM-based studies have placed less focus on sample-preparation workflow and analytical performance in the precise quantification of proteins in saliva, a non-invasively sampled body fluid...
February 24, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28217015/the-pearl-of-fdg-pet-ct-in-preoperative-assessment-of-patients-with-potentially-operable-non-small-cell-lung-cancer-and-its-clinical-impact
#10
Boom Ting Kung, Ting Kun Au Yong, Cheuk Man Tong
The aim of this retrospective study is to evaluate the clinical impact and efficacy of fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) on management decisions for patients suffering from clinically operable non-small-cell lung cancer (NSCLC). A retrospective review of 186 potentially operable NSCLC patients who underwent whole-body PET/CT examination in 2012 was performed. The patients were further analyzed via the electronic patient record (ePR) system for relevant findings...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28202527/-18-f-2s-4r-4-fluoroglutamine-pet-detects-glutamine-pool-size-changes-in-triple-negative-breast-cancer-in-response-to-glutaminase-inhibition
#11
Rong Zhou, Austin R Pantel, Shihong Li, Brian P Lieberman, Karl Ploessl, Hoon Choi, Eric Blankemeyer, Hsiaoju Lee, Hank F Kung, Robert H Mach, David A Mankoff
Glutaminolysis is a metabolic pathway adapted by many aggressive cancers, including triple-negative breast cancers (TNBC), to utilize glutamine for survival and growth. In this study, we examined the utility of [(18)F](2S,4R)4-fluoroglutamine ([(18)F]4F-Gln) PET to measure tumor cellular glutamine pool size, whose change might reveal the pharmacodynamic (PD) effect of drugs targeting this cancer-specific metabolic pathway. High glutaminase (GLS) activity in TNBC tumors resulted in low cellular glutamine pool size assayed via high-resolution (1)H magnetic resonance spectroscopy (MRS)...
March 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28195811/determinants-of-patient-centered-financial-stress-in-patients-with-locally-advanced-head-and-neck-cancer
#12
Jonas A de Souza, Sunny Kung, Jeremy O'Connor, Bonnie J Yap
PURPOSE: To prospectively estimate patient-centered financial stress and its relationship with health care utilization in patients with head and neck cancer. This was a survey-based, longitudinal, prospective study of treatment-naïve patients with stage III, IVa, or IVb locally advanced head and neck cancer at a single-institution tertiary care hospital from May 2013 to November 2014. With 121 patients approached, 73 (60%) agreed to participate. METHODS: Self-reported data were collected on demographics, income, wealth, cost-coping strategies, out-of-pocket costs, supportive medication compliance, and perceived social isolation...
April 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28181380/fisetin-induced-apoptosis-of-human-oral-cancer-scc-4-cells-through-reactive-oxygen-species-production-endoplasmic-reticulum-stress-caspase-and-mitochondria-dependent-signaling-pathways
#13
Chen-Hsuan Su, Chao-Lin Kuo, Kung-Wen Lu, Fu-Shun Yu, Yi-Shih Ma, Jiun-Long Yang, Yung-Lin Chu, Fu-Shin Chueh, Kuo-Ching Liu, Jing-Gung Chung
Oral cancer is one of the cancer-related diseases in human populations and its incidence rates are rising worldwide. Fisetin, a flavonoid from natural products, has been shown to exhibit anticancer activities in many human cancer cell lines but the molecular mechanism of fisetin-induced apoptosis in human oral cancer cells is still unclear; thus, in this study, we investigated fisetin-induced cell death and associated signal pathways on human oral cancer SCC-4 cells in vitro. We examined cell morphological changes, total viable cells, and cell cycle distribution by phase contrast microscopy and flow cytometry assays...
February 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28174654/breast-cancer-with-extensive-bone-metastasis-mimicking-myeloma
#14
Ya-Ting Hsu, Kung-Chao Chang
Punched-out lesions in skull film usually elicit consideration of myeloma. However, some other diseases cause similar clinical presentations. We describe an uncommon presentation of breast cancer, which mimics multiple myeloma. Therefore, in a broad spectrum of clinical settings, physicians should always consider differential diagnosis and await for definitive pathological diagnosis.
February 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28106052/tanshinone-iia-induces-intrinsic-apoptosis-in-osteosarcoma-cells-both-in-vivo-and-in-vitro-associated-with-mitochondrial-dysfunction
#15
Sheng-Teng Huang, Chao-Chun Huang, Wen-Liang Huang, Tsu-Kung Lin, Pei-Lin Liao, Pei-Wen Wang, Chia-Wei Liou, Jiin-Haur Chuang
Tanshinone IIA (Tan IIA), a phytochemical derived from the roots of Salvia miltiorrhiza, has been shown to inhibit growth and induce apoptosis in various cancer cells. The association of its inhibitory effect on the primary malignant bone tumor, osteosarcoma, with mitochondrial dysfunction remains unclear. This study aimed to investigate the anti-proliferative effects of Tan IIA on human osteosarcoma 143B cells both in vitro and in vivo. Administration of Tan IIA to NOD-SCID mice implanted with 143B cells led to significant inhibition of tumor development...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28079881/translational-upregulation-of-aurora-a-by-hnrnp-q1-contributes-to-cell-proliferation-and-tumorigenesis-in-colorectal-cancer
#16
Chien-Hsien Lai, Yu-Chuan Huang, Jenq-Chang Lee, Joseph Ta-Chien Tseng, Kung-Chao Chang, Yen-Ju Chen, Nai-Jhu Ding, Pao-Hsuan Huang, Wen-Chang Chang, Bo-Wen Lin, Ruo-Yu Chen, Yu-Chu Wang, Yi-Chien Lai, Liang-Yi Hung
By using RNA-immunoprecipitation assay following next-generation sequencing, a group of cell cycle-related genes targeted by hnRNP Q1 were identified, including Aurora-A kinase. Overexpressed hnRNP Q1 can upregulate Aurora-A protein, but not alter the mRNA level, through enhancing the translational efficiency of Aurora-A mRNA, either in a cap-dependent or -independent manner, by interacting with the 5'-UTR of Aurora-A mRNA through its RNA-binding domains (RBDs) 2 and 3. By ribosomal profiling assay further confirmed the translational regulation of Aurora-A mRNA by hnRNP Q1...
January 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28077164/erratum-to-novel-sorafenib-analogues-induce-apoptosis-through-shp-1-dependent-stat3-inactivation-in-human-breast-cancer-cells
#17
Chun-Yu Liu, Ling-Ming Tseng, Jung-Chen Su, Kung-Chi Chang, Pei-Yi Chu, Wei-Tien Tai, Chung-Wai Shiau, Kuen-Feng Chen
No abstract text is available yet for this article.
January 11, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28007021/implementation-of-next-generation-sequencing-into-pediatric-hematology-oncology-practice-moving-beyond-actionable-alterations
#18
Jennifer A Oberg, Julia L Glade Bender, Maria Luisa Sulis, Danielle Pendrick, Anthony N Sireci, Susan J Hsiao, Andrew T Turk, Filemon S Dela Cruz, Hanina Hibshoosh, Helen Remotti, Rebecca J Zylber, Jiuhong Pang, Daniel Diolaiti, Carrie Koval, Stuart J Andrews, James H Garvin, Darrell J Yamashiro, Wendy K Chung, Stephen G Emerson, Peter L Nagy, Mahesh M Mansukhani, Andrew L Kung
BACKGROUND: Molecular characterization has the potential to advance the management of pediatric cancer and high-risk hematologic disease. The clinical integration of genome sequencing into standard clinical practice has been limited and the potential utility of genome sequencing to identify clinically impactful information beyond targetable alterations has been underestimated. METHODS: The Precision in Pediatric Sequencing (PIPseq) Program at Columbia University Medical Center instituted prospective clinical next generation sequencing (NGS) for pediatric cancer and hematologic disorders at risk for treatment failure...
December 23, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27885991/retraction-mmp-13-is-involved-in-oral-cancer-cell-metastasis
#19
Shun-Hong Huang, Ching-Hsuan Law, Ping-Hsueh Kuo, Ren-Yu Hu, Ching-Chieh Yang, Ting-Wen Chung, Ji-Min Li, Li-Hsun Lin, Yi-Chung Liu, En-Chi Liao, Yi-Ting Tsai, Yu-Shan Wei, Chi-Chen Lin, Chien-Wen Chang, Hsiu-Chuan Chou, Wen-Ching Wang, Margaret Dah-Tsyr Chang, Lu-Hai Wang, Hsing-Jien Kung, Hong-Lin Chan, Ping-Chiang Lyu
HASH(0x41b9bc8)
July 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27829231/deregulation-of-small-non-coding-rnas-at-the-dlk1-dio3-imprinted-locus-predicts-lung-cancer-patient-outcome
#20
Katey S S Enfield, Victor D Martinez, Erin A Marshall, Greg L Stewart, Sonia H Y Kung, Jhon R Enterina, Wan L Lam
Deregulation of the imprinted DLK1-DIO3 locus at chromosome 14q32.1-14q32.31 has been associated with developmental and respiratory disorders, including cancer. In lung cancer, deregulation of imprinting at DLK1-DIO3 was recently described in smokers. Deregulated expression of a microRNA (miRNA) cluster mapping to this locus was also associated with patient outcome, suggesting the importance of this locus to lung cancer disease phenotypes. The DLK1-DIO3 locus is complex, and encodes several protein-coding genes, in addition to long and short non-coding RNAs...
December 6, 2016: Oncotarget
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