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https://www.readbyqxmd.com/read/28822511/comparison-of-different-cardiovascular-risk-score-calculators-for-cardiovascular-risk-prediction-and-guideline-recommended-statin-uses
#1
Naveen Garg, Subrat K Muduli, Aditya Kapoor, Satyendra Tewari, Sudeep Kumar, Roopali Khanna, Pravin Kumar Goel
OBJECTIVE: The accuracy of various 10-year cardiovascular disease (CVD) risk calculators in Indians may not be the same as in other populations. Present study was conducted to compare the various calculators for CVD risk assessment and statin eligibility according to different guidelines. METHODS: Consecutive 1110 patients who presented after their first myocardial infarction were included. Their CVD risk was calculated using Framingham Risk score- Coronary heart disease (FRS-CHD), Framingham Risk Score- Cardiovascular Disease (FRS-CVD), QRISK2, Joint British Society risk calculator 3 (JBS3), American College of Cardiology/American Heart Association (ACC/AHA), atherosclerotic cardiovascular disease (ASCVD) and WHO risk charts, assuming that they had presented one day before cardiac event for risk assessment...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28821330/systemic-atrioventricular-valve-excision-and-ventricular-assist-devices-in-pediatric-patients
#2
Deipanjan Nandi, Kelley D Miller, Carley M Bober, Tami M Rosenthal, Lisa M Montenegro, Joseph W Rossano, J William Gaynor, Christopher E Mascio
BACKGROUND: Continuous-flow ventricular assist devices (CF VADs) designed for adults are increasingly used in pediatric patients. However, there is greater risk of device inflow obstruction as a result of size and anatomy. METHODS: We reviewed all cases of systemic atrioventricular valve (AVV) excision with HeartWare HVAD (HeartWare, Framingham, MA) implantation in the systemic ventricle performed at our institution from November 2015 to May 2016. RESULTS: AVV excision with CF VAD implantation was undertaken in 3 patients...
August 16, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28820441/genome-wide-interaction-study-of-omega-3-pufas-and-other-fatty-acids-on-inflammatory-biomarkers-of-cardiovascular-health-in-the-framingham-heart-study
#3
Jenna Veenstra, Anya Kalsbeek, Jason Westra, Craig Disselkoen, Caren Smith, Nathan Tintle
Numerous genetic loci have been identified as being associated with circulating fatty acid (FA) levels and/or inflammatory biomarkers of cardiovascular health (e.g., C-reactive protein). Recently, using red blood cell (RBC) FA data from the Framingham Offspring Study, we conducted a genome-wide association study of over 2.5 million single nucleotide polymorphisms (SNPs) and 22 RBC FAs (and associated ratios), including the four Omega-3 FAs (ALA, DHA, DPA, and EPA). Our analyses identified numerous causal loci...
August 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28811088/primary-prevention-aspirin-use-in-high-risk-patients-a-pharmacist-intervention-and-comparison-of-risk-stratification-tools
#4
Scott A Coon, Amie D Brooks, Stephen E Wolff
OBJECTIVES: The objectives of this project are 1) to describe aspirin use for primary prevention in an underserved, minority population; 2) to determine the impact of a pharmacist-led intervention on the prevalence of aspirin use for primary prevention; and 3) to compare aspirin indications based on Framingham Risk Score (FRS) and atherosclerotic cardiovascular disease (ASCVD) risk score. METHODS: Men and women age 45-79 and 55-79 years, respectively, without ASCVD were screened for aspirin use...
August 12, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28809051/mediation-analysis-for-a-survival-outcome-with-time-varying-exposures-mediators-and-confounders
#5
Sheng-Hsuan Lin, Jessica G Young, Roger Logan, Tyler J VanderWeele
We propose an approach to conduct mediation analysis for survival data with time-varying exposures, mediators, and confounders. We identify certain interventional direct and indirect effects through a survival mediational g-formula and describe the required assumptions. We also provide a feasible parametric approach along with an algorithm and software to estimate these effects. We apply this method to analyze the Framingham Heart Study data to investigate the causal mechanism of smoking on mortality through coronary artery disease...
August 15, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28805026/correlation-of-6-minute-walk-test-with-left-ventricular-function-and-quality-of-life-in-heart-failure-due-to-chagas-disease
#6
Mayara da Costa Chambela, Mauro Felippe Felix Mediano, Roberto Rodrigues Ferreira, André Miguel Japiassú, Mariana Caldas Waghabi, Gilberto Marcelo Sperandio da Silva, Roberto Magalhães Saraiva
OBJECTIVES: To evaluate the correlation of the total distance walked during the six-minute walk test (6-MWT) with left ventricular function and quality of life in patients with Chagas Disease (ChD) complicated by heart failure. METHODS: This cross-sectional study of adult patients with ChD and heart failure diagnosed based on Framingham criteria. 6MWT was performed following international guidelines. New York Heart Association functional class, brain natriuretic peptide (BNP) serum levels, echocardiographic parameters, and quality of life (SF-36 and MLHFQ questionnaires) were determined and their correlation with the distance covered at the 6MWT was tested...
August 14, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28802734/adding-markers-of-organ-damage-to-risk-score-models-improves-cardiovascular-risk-assessment-prospective-analysis-of-a-large-cohort-of-adult-outpatients
#7
Giuliano Tocci, Ilaria Figliuzzi, Vivianne Presta, Nadia Attalla El Halabieh, Barbara Citoni, Roberta Coluccia, Allegra Battistoni, Andrea Ferrucci, Massimo Volpe
INTRODUCTION: Global cardiovascular (CV) risk stratification is recommended in all outpatients. Risk score charts, however, do not include markers of organ damage (OD). AIM: To evaluate the potential added value of including different markers of subclinical OD to US Framingham, European SCORE and Italian Cuore risk score calculators. METHODS: We prospectively evaluated adult outpatients, who underwent blood pressure (BP) assessment and global CV risk stratification...
July 25, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28802304/coffee-consumption-and-coronary-heart-disease-risk-using-the-framingham-risk-score
#8
Hye-Mi Noh, Yong Soon Park, Jeong-Hyeon Kim
BACKGROUND AND OBJECTIVES: Although concerns regarding the influence of coffee consumption on human health have accompanied the massive increase in coffee consumption, the effects of coffee intake on the risk for coronary heart disease (CHD) remain controversial. Therefore, we evaluated the association between coffee consumption and CHD risk as estimated using the Framingham risk model in Korean adults. METHODS AND STUDY DESIGN: This cross-sectional study involved 3,987 participants aged 30-74 years who participated in the fifth Korea National Health and Nutrition Examination Survey conducted in 2010...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28801428/relationship-between-estimated-cardiovascular-disease-risk-and-insulin-resistance-in-a-black-african-population-living-with-hiv-a-cross-sectional-study-from-cameroon
#9
Steve Raoul Noumegni, Jean Joel Bigna, Vicky Jocelyne Ama Moor Epse Nkegoum, Jobert Richie Nansseu, Felix K Assah, Ahmadou Musa Jingi, Magellan Guewo-Fokeng, Steve Leumi, Jean-Claude Katte, Mesmin Y Dehayem, Liliane Mfeukeu Kuate, Andre Pascal Kengne, Eugene Sobngwi
OBJECTIVES: Cardiovascular disease (CVD) and metabolic diseases are growing concerns among patients with HIV infection as a consequence of the improving survival of this population. We aimed to assess the relationship between CVD risk and insulin resistance in a group of black African individuals with HIV infection. METHODS: This cross-sectional study involved patients with HIV infection aged 30-74 years and followed up at the Yaoundé Central Hospital, Cameroon...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28800398/a-13-week-randomized-pilot-trial-of-a-low-glycemic-load-diet-and-lifestyle-modification-program-combining-low-glycemic-load-protein-shakes-and-targeted-nutraceuticals-improved-weight-loss-and-cardio-metabolic-risk-factors-over-a-low-glycemic-load-diet-alone
#10
Clinton J Dahlberg, Joseph J Ou, John G Babish, Joseph J Lamb, Sarah Eliason, Holly Brabazon, Wei Gao, Mohan R Kaadige, Matthew L Tripp
An open label, randomized, exploratory study comprising 44 healthy, overweight subjects with cardio-metabolic syndrome (CMS) risk factors was conducted to assess the safety, tolerability and efficacy of a proprietary lifestyle modification program without (DIET) and with (PROG) targeted nutraceutical supplementation including soy, pea and whey proteins, phytosterols, antioxidants, probiotics, fish oil and berberine over 13-weeks. Key metrics were recorded at baseline, weeks 9 and 13. For DIET and PROG compliance was 85% and 86%, respectively, with no adverse events related to the diet or supplements...
August 11, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28797575/cardiovascular-risk-profile-in-burn-survivors
#11
Becky Leung, John F Younger, Kellie Stockton, Michael Muller, Jennifer Paratz
OBJECTIVE: Burn patients have prolonged derangements in metabolic, endocrine, cardiac and psychosocial systems, potentially impacting on their cardiovascular health. There are no studies on the risk of cardiovascular disease (CVD) after-burn. The aim of our study was to record lipid values and evaluate CVD risk in adult burn survivors. METHODS: In a cross-sectional study patients ≥18 years with burn injury between 18-80% total burn surface area (TBSA) from 1998 to 2012 had total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides measured via finger prick...
August 7, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28792141/validation-of-a-newly-developed-equation-for-estimating-serum-apolipoprotein-b-associations-with-cardiovascular-disease-surrogate-markers-in-koreans
#12
Jong Dai Kim, You Cheol Hwang, Hong Yup Ahn, Cheol Young Park
PURPOSE: Many clinical guidelines recommend apolipoprotein B (apoB) measurement, particularly in subjects with metabolic syndrome or type 2 diabetes. Recently, we developed a new equation to estimate serum apoB (apoBE). We validated the clinical relevance of apoBE and compared the performance of the equation with conventional lipid measurements and direct measurement of apoB. MATERIALS AND METHODS: Study subjects were recruited from patients who visited the Health Screening Center at Kangbuk Samsung Hospital between January and December 2009 for routine medical examinations (n=78125)...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28792138/association-of-inter-arm-systolic-blood-pressure-difference-with-coronary-atherosclerotic-disease-burden-using-calcium-scoring
#13
Ae Young Her, Kyoung Im Cho, Scot Garg, Yong Hoon Kim, Eun Seok Shin
PURPOSE: There are no sufficient data on the correlation between inter-arm blood pressure (BP) difference and coronary atherosclerosis found using coronary artery calcium score (CACS). We aimed to investigate if the increased difference in inter-arm BP is independently associated with severity of CACS. MATERIALS AND METHODS: Patients who had ≥3 cardiovascular risk factors or an intermediate Framingham Risk Score (FRS; ≥10) were enrolled. Inter-arm BP difference was defined as the absolute difference in BP in both arms...
September 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28772335/qtc-interval-in-adolescents-and-young-athletes-influence-of-correction-formulas
#14
Salvatore Francesco Gervasi, Massimiliano Bianco, Vincenzo Palmieri, Francesco Cuccaro, Paolo Zeppilli
A QTc interval at the upper limits in young athletes can be challenging. Regardless of factors able to influence it (age, electrolytes, etc.), several authors underlined that rate correction formulas can often underestimate/overestimate it. Our objective was to identify the most reliable formula and relative upper normal limit of QTc for this population. The rest ECG of 701 healthy elite male athletes was analyzed. QTc was calculated with 4 formulas (Bazett, Fridericia, Framingham, Hodges). Correlation/regression analysis of QTc vs...
August 3, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28771097/dependency-of-cardiovascular-risk-on-reproductive-stages-and-on-age-among-middle-aged-chinese-women
#15
Y Sun, X Ruan, A O Mueck
OBJECTIVE: To assess the 10-year cardiovascular risk in middle-aged Chinese women living in the same community and the impact of reproductive aging and age. METHODS: This was a cross-sectional study in the Yuetan Community of Beijing. Data on lifestyle habits, prevalence and treatment of chronic diseases with significance for cardiovascular disease (CVD) development were collected by interview. CVD risk factors were assessed by physical examination and laboratory tests...
August 3, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28768835/associations-of-dairy-intake-with-incident-prediabetes-or-diabetes-in-middle-aged-adults-vary-by-both-dairy-type-and-glycemic-status
#16
Adela Hruby, Jiantao Ma, Gail Rogers, James B Meigs, Paul F Jacques
Background: Inconsistent evidence describes the association between dietary intake of dairy and milk-based products and type 2 diabetes (T2D) risk.Objective: Our objective was to assess associations between consumption of milk-based products, incident prediabetes, and progression to T2D in the Framingham Heart Study Offspring Cohort.Methods: Total dairy and milk-based product consumption was assessed by ≤4 food-frequency questionnaires across a mean of 12 y of follow-up in 2809 participants [mean ± SD age: 54...
August 2, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28761616/cardiometabolic-risk-among-hiv-positive-ugandan-adults-prevalence-predictors-and-effect-of-long-term-antiretroviral-therapy
#17
Patrick Kazooba, Ivan Kasamba, Billy Nsubuga Mayanja, Joseph Lutaakome, Ivan Namakoola, Tino Salome, Pontiano Kaleebu, Paula Munderi
INTRODUCTION: We investigated the prevalence, predictors of and effect of Antiretroviral Therapy (ART) regimen on cardiometabolic risk among HIV-positive Ugandan adults at enrolment into a prospective cohort to study the Complications of Long-Term ART (CoLTART). METHODS: We collected data on cardiometabolic risk factors including dyslipidemia, hypertension, hyperglycemia, obesity and calculated the mean atherogenic index for Plasma (AIP) and 10 year Framingham risk score (FHS)...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28760596/serum-resistin-levels-inversely-associated-with-cardiovascular-risk-indices-in-type-2-diabetics-from-central-mexico
#18
Dania G Solis-Cano, Leonardo M Porchia, M Elba Gonzalez-Mejia, Ricardo Pérez-Fuentes, Guadalupe Ruiz-Vivanco, Adriana Nieva-Vazquez, Enrique Torres-Rasgado
AIMS: Since, resistin has been associated with coronary heart disease and with the progression of Type 2 Diabetes (T2D), our objective was to determine the correlation between resistin and cardiovascular risk (CVR) in subjects with increasing degrees of hyperglycemia. METHODS: Using a cross-sectional study design, the anthropometric and biochemical profiles were collected from 180 subjects from Puebla, Mexico. Subjects were separated into Normoglycemic (NGT), pre-diabetic (PT2D), or T2D...
July 25, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28757482/association-between-high-sensitivity-cardiac-troponin-i-and-cardiac-events-in-elderly-women
#19
Joshua R Lewis, Wai H Lim, Germaine Wong, Samuel Abbs, Kun Zhu, Ee M Lim, Peter L Thompson, Richard L Prince
BACKGROUND: Elderly women are at high risk of coronary heart disease (CHD) and heart failure. High-sensitivity assays allow detection of cardiac troponin I (hsTnI) well below diagnostic cutoffs for acute coronary syndrome. We investigated the association between these levels with future cardiac events in community-based ambulant white women aged over 70 years initially recruited for a 5-year randomized, controlled trial of calcium supplements. METHODS AND RESULTS: This was a prospective study of 1081 elderly women without clinical CHD at baseline (1998) or hsTnI above the diagnostic cutoffs for acute coronary syndrome with 14...
July 30, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28754402/cardiovascular-risk-factors-in-patients-with-spondyloarthritis-from-northern-european-and-mediterranean-countries-an-ancillary-study-of-the-asas-comospa-project
#20
Clementina López-Medina, Yolanda Jiménez-Gómez, Anna Moltó, Ruxandra Elena Schiotis, Helena Marzo-Ortega, Floris A van Gaalen, Salih Ozgocmen, Maxime Dougados, Jerusalem Calvo-Gutiérrez, M Carmen Castro-Villegas, Eduardo Collantes-Estévez, Pilar Font-Ugalde
OBJECTIVES: The objectives of this study were: 1) To compare the prevalence of cardiovascular disease and cardiovascular risk factors among different phenotypes of Spondyloarthritis (SpA); 2) To assess the differences in cardiovascular disease and cardiovascular risk factors between two geographical areas, i.e. Northern Europe vs. Mediterranean region; 3) To identify potential predictive factors for high Framingham Risk Score regarding disease features in SpA and geographical area. METHODS: Ancillary analysis of the international, multicentric, observational, cross-sectional ASAS-COMOSPA study...
July 25, 2017: Joint, Bone, Spine: Revue du Rhumatisme
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