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https://www.readbyqxmd.com/read/29458073/establishment-and-validation-of-a-prediction-model-for-ischemic-stroke-risks-in-patients-with-type-2-diabetes
#1
Tsai-Chung Li, Hsiang-Chi Wang, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Chih-Hsueh Lin, Sing-Yu Yang, Cheng-Chieh Lin
AIMS: A risk scoring system for predicting ischemic stroke incidence may identify type 2 diabetes patients at high risk for ischemic stroke who can benefit from preventive intervention programs. Such a risk scoring system can serve as a benchmark to test novel putative risk factors. METHODS: The study adopted a retrospective cohort, including 28,124 Chinese patients with type 2 diabetes aged 30-84 years during 2001-2004. Participants were randomly assigned to the derivation and validation sets at a 2:1 ratio...
February 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29456025/effectiveness-of-user-and-expert-driven-web-based-hypertension-programs-an-rct
#2
Sam Liu, Dina Brooks, Scott G Thomas, Gunther Eysenbach, Robert P Nolan
INTRODUCTION: The effectiveness of self-guided Internet-based lifestyle counseling (e-counseling) varies, depending on treatment protocol. Two dominant procedures in e-counseling are expert- and user-driven. The influence of these procedures on hypertension management remains unclear. The objective was to assess whether blood pressure improved with expert-driven or user-driven e-counseling over control intervention in patients with hypertension over a 4-month period. STUDY DESIGN: This study used a three-parallel group, double-blind randomized controlled design...
February 15, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29452783/oxidative-stress-is-increased-in-sarcopenia-and-associated-with-cardiovascular-disease-risk-in-sarcopenic-obesity
#3
Francesco Bellanti, Antonino D Romano, Aurelio Lo Buglio, Valeria Castriotta, Giuseppe Guglielmi, Antonio Greco, Gaetano Serviddio, Gianluigi Vendemiale
OBJECTIVES: To define whether circulating markers of oxidative stress correlate with sarcopenia in terms of glutathione balance and oxidative protein damage, and whether these biomarkers are associated with risk of cardiovascular disease (CVD). STUDY DESIGN: Population-based cross-sectional study. 115 out of 347 elderly subjects were classified as non-sarcopenic non-obese (NS-NO), sarcopenic non-obese (S-NO), non-sarcopenic obese (NS-O), and sarcopenic obese (S-O)...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29447790/fine-particulate-matter-and-incident-coronary-heart-disease-in-the-regards-cohort
#4
Matthew Shane Loop, Leslie A McClure, Emily B Levitan, Mohammad Z Al-Hamdan, William L Crosson, Monika M Safford
Chronic exposure to fine particulate matter (PM 2.5 ) is accepted as a causal risk factor for coronary heart disease (CHD). However, most of the evidence for this hypothesis is based upon cohort studies in whites, comprised of either only males or females who live in urban areas. It is possible that many estimates of the effect of chronic exposure to PM 2.5 on risk for CHD do not generalize to more diverse samples. METHODS: Therefore, we estimated the relationship between chronic exposure to PM 2...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29444987/cardiovascular-risk-prediction-functions-underestimate-risk-in-hiv-infection
#5
Virginia A Triant, Jeremiah Perez, Susan Regan, Joseph M Massaro, James B Meigs, Steven K Grinspoon, Ralph B D'Agostino
Background -Cardiovascular disease (CVD) risk is elevated in HIV-infected individuals, with contributions from both traditional and non-traditional risk factors. The accuracy of established CVD risk prediction functions in HIV is uncertain. We sought to assess the performance of three established CVD risk prediction functions in a longitudinal cohort of HIV-infected men. Methods -Framingham Heart Study (Framingham) functions for hard coronary heart disease (Framingham CHD) and atherosclerotic CVD (Framingham ASCVD) and the American College of Cardiology/American Heart Association (ACC/AHA ASCVD) function were applied to the Partners HIV cohort...
February 14, 2018: Circulation
https://www.readbyqxmd.com/read/29443425/long-term-atherosclerotic-vascular-disease-risk-and-prognosis-in-elderly-women-with-abdominal-aortic-calcification-on-lateral-spine-images-captured-during-bone-density-testing-a-prospective-study
#6
Joshua R Lewis, John T Schousboe, Wai H Lim, Germaine Wong, Kevin E Wilson, Kun Zhu, Peter L Thompson, Douglas P Kiel, Richard L Prince
Lateral spine images are captured using bone densitometers for vertebral fracture assessment (VFA) in older women. Abdominal aortic calcification (AAC) is commonly seen on these images however the long-term prognosis in women with AAC remains uncertain. In a prospective study of 1,052 community-dwelling ambulant Caucasian women over 70 years AAC24 scores were calculated from digital lateral spine images captured during bone density testing in 1998 or 1999. Cardiovascular risk factors were assessed in 1998 while 14...
February 14, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29436010/changes-in-total-cardiac-output-and-oxygen-extraction-during-exercise-in-patients-supported-with-an-hvad-left-ventricular-assist-device
#7
Thomas Schmidt, Birna Bjarnason-Wehrens, Stephanie Mommertz, Meike Hannig, Sebastian Schulte-Eistrup, Detlev Willemsen, Nils Reiss
Following implantation of a left ventricular assist device (LVAD), acceptable functional performance is now being achieved; however, peak VO 2 and peak work load (watts) remain considerably limited. Maximum physical capacity is essentially dependent on generated cardiac output (CO) and arteriovenous oxygen difference (avDO 2 ). We investigated the changes in CO and avDO 2 during exercise in LVAD patients with an HVAD pump (HeartWare Inc., Framingham, MA, USA). Approximately 6 weeks after implantation, 20 patients (100% male, 60...
February 12, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29433344/association-of-cardiovascular-risk-factors-on-myocardial-perfusion-and-fibrosis-in-asymptomatic-individuals-cardiac-magnetic-resonance-study
#8
Min Jae Cha, Sung Mok Kim, Hyun Su Kim, Yiseul Kim, Yeon Hyeon Choe
Background Myocardial perfusion reserve index (MPRI) and extracellular volume fraction (ECV) on cardiac magnetic resonance (CMR) are known to quantify coronary microvascular dysfunction and myocardial fibrosis, respectively. Purpose To demonstrate that cardiovascular risk factors such as hypertension, diabetes, hyperlipidemia, and smoking are correlated with MPRI and ECV on CMR in asymptomatic individuals. Material and Methods Between October 2013 and July 2014, 196 individuals underwent CMR. After excluding those with chest pain, arrhythmia, and obstructive coronary artery disease, participants were divided into five groups: those without risk factor (n = 26) and those with one (n = 43), two (n = 35), three (n = 24), or four (n = 6) risk factors...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29431520/beneficial-effects-of-acute-trans-resveratrol-supplementation-in-treated-hypertensive-patients-with-endothelial-dysfunction
#9
B C A A Marques, M Trindade, J C F Aquino, A R Cunha, R O Gismondi, M F Neves, W Oigman
Endothelial dysfunction is a surrogate marker of cardiovascular risk. Resveratrol is known to improve endothelial function in animals, however, clinical trials are limited. We hypothesized that the acute trans-resveratrol supplementation improves endothelial function in treated hypertensive patients with endothelial dysfunction. Twenty-four hypertensive patients between 45 and 65 years-old with baseline endothelial dysfunction were enrolled in a randomized, cross-over, double-blind, placebo-controlled trial...
February 12, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29423652/deep-sequencing-of-the-mitochondrial-genome-reveals-common-heteroplasmic-sites-in-nadh-dehydrogenase-genes
#10
Chunyu Liu, Jessica L Fetterman, Poching Liu, Yan Luo, Martin G Larson, Ramachandran S Vasan, Jun Zhu, Daniel Levy
Increasing evidence implicates mitochondrial dysfunction in aging and age-related conditions. But little is known about the molecular basis for this connection. A possible cause may be mutations in the mitochondrial DNA (mtDNA), which are often heteroplasmic-the joint presence of different alleles at a single locus in the same individual. However, the involvement of mtDNA heteroplasmy in aging and age-related conditions has not been investigated thoroughly. We deep-sequenced the complete mtDNA genomes of 356 Framingham Heart Study participants (52% women, mean age 43, mean coverage 4570-fold), identified 2880 unique mutations and comprehensively annotated them by MITOMAP and PolyPhen-2...
February 8, 2018: Human Genetics
https://www.readbyqxmd.com/read/29419568/recent-abacavir-use-increases-risk-for-types-1-and-2-myocardial-infarctions-among-adults-with-hiv
#11
Richard A Elion, Keri N Althoff, Jinbing Zhang, Richard D Moore, Stephen J Gange, Mari M Kitahata, Heidi M Crane, Daniel R Drozd, James H Stein, Marina B Klein, Joseph J Eron, Michael J Silverberg, William C Mathews, Amy C Justice, Timothy R Sterling, Charles S Rabkin, Angel M Mayor, Daniel B Klein, Michael A Horberg, Ronald J Bosch, Oghenowede Eyawo, Frank J Palella
BACKGROUND: There is persistent confusion as to whether abacavir (ABC) increases the risk for myocardial infarction (MI), and whether such risk differs by Type 1 (T1MI) or 2 (T2MI) MI in adults with HIV. METHODS: Incident MIs in NA-ACCORD participants were identified from 2001 to 2013. Discrete time marginal structural models addressed channeling biases and time-dependent confounding to estimate crude (HR) and adjusted hazard ratios (aHR) and 95% confidence intervals; analyses were performed for T1MI and T2MI separately...
February 6, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29419462/gaps-in-diagnosis-and-treatment-of-cardiovascular-risk-factors-in-patients-with-psoriatic-disease-an-international-multicenter-study
#12
Lihi Eder, Paula Harvey, Vinod Chandran, Cheryl F Rosen, Jan Dutz, James T Elder, Proton Rahman, Christopher T Ritchlin, Sherry Rohekar, Richard Hayday, Snezana Barac, Joy Feld, Devy Zisman, Dafna D Gladman
OBJECTIVE: We aimed to estimate the proportion of underdiagnosis and undertreatment of cardiovascular risk factors (CVRF) in an international multicenter cohort of patients with psoriasis and psoriatic arthritis (PsA). METHODS: A cross-sectional analysis was conducted of patients with psoriatic disease from the International Psoriasis and Arthritis Research Team cohort. The presence of modifiable CVRF [diabetes, hypertension (HTN), dyslipidemia, smoking, elevated body mass index, and central obesity] and the use of appropriate therapies for HTN and dyslipidemia were determined...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29412240/leisure-time-physical-activity-but-not-commuting-physical-activity-is-associated-with-cardiovascular-risk-among-elsa-brasil-participants
#13
Francisco José Gondim Pitanga, Sheila M A Matos, Maria da Conceição Almeida, Sandhi Maria Barreto, Estela M L Aquino
BACKGROUND: Despite reports in the literature that both leisure-time physical activity (LTPA) and commuting physical activity (CPA) can promote health benefits, the literature lacks studies comparing the associations of these domains of physical activity with cardiovascular risk scores. OBJECTIVE: To investigate the association between LTPA and CPA with different cardiovascular risk scores in the cohort of the Longitudinal Study of Adult Health ELSA-Brasil. METHODS: Cross-sectional study with data from 13,721 participants of both genders, aged 35-74 years, free of cardiovascular disease, from ELSA Brazil...
February 1, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29411690/a-new-selection-method-to-increase-the-health-benefits-of-cvd-prevention-strategies
#14
Ghizelda R Lagerweij, G Ardine de Wit, Karel Gm Moons, Yvonne T van der Schouw, Wm Monique Verschuren, Jannick An Dorresteijn, Hendrik Koffijberg
Background Cardiovascular disease (CVD) prevention is commonly focused on providing individuals at high predicted CVD risk with preventive medication. Whereas CVD risk increases rapidly with age, current risk-based selection of individuals mainly targets the elderly. However, the lifelong (preventable) consequences of CVD events may be larger in younger individuals. The purpose of this paper is to investigate if health benefits from preventive treatment may increase when the selection strategy is further optimised...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29411130/sarcopenia-in-cancer-survivors-is-associated-with-increased-cardiovascular-disease-risk
#15
Su Jung Lee, Yoon Jin Park, Kathleen B Cartmell
PURPOSE: The aim of this study was to assess the association between sarcopenia and cardiovascular disease (CVD) risk in cancer survivors. METHODS: We analyzed a consecutive series of 683 cancer survivors from the Korean National Health and Nutritional Exam Survey (2008-2011 years). Sarcopenia was defined as the appendicular skeletal muscle mass divided by weight (Kg) < 1 standard deviation below the sex-specific healthy population aged 20-39 years. CVD risks were assessed using the Framingham Risk Score (FRS), which were divided by tertile...
February 6, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29410481/body-fat-percentage-cutoffs-for-risk-of-cardiometabolic-abnormalities-in-the-chinese-adult-population-a-nationwide-study
#16
Aihua Jia, Shaoyong Xu, Jie Ming, Ying Xing, Jianhua Guo, Mingwei Zhao, Li Zhang, Qiuhe Ji
BACKGROUND/OBJECTIVES: The direct assessment of body fat (BF) by using simple methods might be an alternative index of obesity. We aim to investigate the optimal cutoffs of the %BF relating to metabolic disorders and cardiovascular risks in China. SUBJECTS/METHODS: The data were from the 2007-2008 China National Diabetes and Metabolic Disorders Study. Participants with age of 20-75 years and with a BF measurement record were included. The %BF was measured using a foot-to-foot bioelectrical impedance analysis...
February 6, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29407876/cardiovascular-disease-in-systemic-lupus-erythematosus-is-associated-with-increased-levels-of-biomarkers-reflecting-receptor-activated-apoptosis
#17
Maria Wigren, Elisabet Svenugnsson, Ingrid Yao Mattisson, Johanna T Gustafsson, Iva Gunnarsson, Agneta Zickert, Kerstin Elvin, Kerstin Jensen-Urstad, Anders Bengtsson, Birgitta Gullstrand, Gunilla Nordin Fredrikson, Jan Nilsson
BACKGROUND AND AIMS: There is convincing evidence that adaptive immune responses affect the development of atherosclerosis and thrombosis and several autoimmune diseases are associated with increased cardiovascular risk. However, our understanding of the underlying mechanisms remains limited. We investigated how biomarkers reflecting four aspects of autoimmunity: apoptosis, inflammation, tissue degradation and repair, associate with cardiovascular disease (CVD) in subjects with systemic lupus erythematosus (SLE)...
January 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29407113/cardiovascular-disease-risk-prediction-in-sub-saharan-african-populations-comparative-analysis-of-risk-algorithms-in-the-rodam-study
#18
Daniel Boateng, Charles Agyemang, Erik Beune, Karlijn Meeks, Liam Smeeth, Matthias B Schulze, Juliet Addo, Ama de-Graft Aikins, Cecilia Galbete, Silver Bahendeka, Ina Danquah, Peter Agyei-Baffour, Ellis Owusu-Dabo, Frank P Mockenhaupt, Joachim Spranger, Andre P Kengne, Diederick E Grobbee, Kerstin Klipstein-Grobusch
BACKGROUND: Validated absolute risk equations are currently recommended as the basis of cardiovascular disease (CVD) risk stratification in prevention and control strategies. However, there is no consensus on appropriate equations for sub-Saharan African populations. We assessed agreement between different cardiovascular risk equations among Ghanaian migrant and home populations with no overt CVD. METHODS: The 10-year CVD risks were calculated for 3586 participants aged 40-70years in the multi-centre RODAM study among Ghanaians residing in Ghana and Europe using the Framingham laboratory and non-laboratory and Pooled Cohort Equations (PCE) algorithms...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29407079/identification-risk-assessment-and-management-of-patients-with-atrial-fibrillation-in-a-large-primary-care-cohort
#19
Katrina K Poppe, Robert N Doughty, Matire Harwood, P Alan Barber, Jeff Harrison, Rod Jackson, Sue Wells
BACKGROUND: Atrial fibrillation (AF) is associated with increased risk of cardiovascular disease (CVD) complications including stroke. We investigated the assessment and management of cardiovascular risk among patients with AF aged 35-74years, by ethnic group, in a large cohort of people receiving a CVD risk assessment in primary care (PREDICT). METHODS: PREDICT was linked to national dispensing, hospitalisation and mortality records. AF was present if recorded in PREDICT or during a prior hospitalisation; medications were those dispensed ≤6months before or after a PREDICT assessment; the CHA 2 DS 2 -VASc score and a New Zealand (NZ) adjusted Framingham CVD risk were calculated...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29398680/screening-validity-of-arterial-pressure-volume-index-and-arterial-velocity-pulse-index-for-preclinical-atherosclerosis-in-japanese-community-dwelling-adults-the-nagasaki-islands-study
#20
Hirotomo Yamanashi, Jun Koyamatsu, Mako Nagayoshi, Yuji Shimizu, Shin-Ya Kawashiri, Hideaki Kondo, Shoichi Fukui, Mami Tamai, Takahiro Maeda
AIM: The arterial pressure-volume index (API) and arterial velocity-pulse index (AVI) are novel measurement indices of arterial stiffness. This study was performed to examine the screening validity of the API and AVI for preclinical atherosclerosis in Japanese community-dwelling adults. METHODS: We conducted a cross-sectional study of 2,809 participants aged ≥40 years who underwent Japanese national medical check-ups from 2014 to 2016. Preclinical atherosclerosis was defined as a mean carotid intima-media thickness (CIMT) of ≥1...
February 3, 2018: Journal of Atherosclerosis and Thrombosis
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