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Beatrice von Jeinsen, Meghan I Short, Vanessa Xanthakis, Herman Carneiro, Susan Cheng, Gary F Mitchell, Ramachandran S Vasan
BACKGROUND: Adipokines mediate cardiometabolic risk associated with obesity but their role in the pathogenesis of obesity-associated heart failure remains uncertain. We investigated the associations between circulating adipokine concentrations and echocardiographic measures in a community-based sample. METHODS AND RESULTS: We evaluated 3514 Framingham Heart Study participants (mean age 40 years, 53.8% women) who underwent routine echocardiography and had select circulating adipokines measured, ie, leptin, soluble leptin receptor, fatty acid-binding protein 4, retinol-binding protein 4, fetuin-A, and adiponectin...
June 21, 2018: Journal of the American Heart Association
Marina Navarro-Peñalver, M Teresa Perez-Martinez, Manuel Gómez-Bueno, Pablo García-Pavía, Josep Lupón-Rosés, Eulalia Roig-Minguell, Josep Comin-Colet, Antoni Bayes-Genis, Jose A Noguera, Domingo A Pascual-Figal
BACKGROUND: Testosterone deficiency is associated with heart failure (HF) progression and poor prognosis. Testosterone therapy has been shown to improve exercise capacity in patients with chronic HF, but no trial has evaluated the impact of replacement in patients with demonstrated testosterone deficiency. METHODS: Prospective, randomized, double-blind, placebo-controlled, and parallel-group trial comparing testosterone replacement with placebo in males with chronic HF with reduced ejection fraction (HFrEF) and testosterone deficiency (NCT01813201)...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
Vandenberk Bert, Vandael Eline, Robyns Tomas, Vandenberghe Joris, Garweg Christophe, Foulon Veerle, Ector Joris, Willems Rik
BACKGROUND: Incorporation of QTc in clinical decision support systems requires accurate QT-interval correction, also during common ECG abnormalities as ventricular conduction defects (VCD). We compared the performance and predictive value of QT correction formulas to design a patient-specific QT correction algorithm (QTcA). METHODS: The first ECG in adult patients with sinus rhythm (SR), atrial fibrillation (AF) and ventricular pacing (VP) was collected retrospectively...
June 21, 2018: Pacing and Clinical Electrophysiology: PACE
Pascal Geldsetzer, Jennifer Manne-Goehler, Michaela Theilmann, Justine I Davies, Ashish Awasthi, Goodarz Danaei, Thomas A Gaziano, Sebastian Vollmer, Lindsay M Jaacks, Till Bärnighausen, Rifat Atun
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality in India. Yet, evidence on the CVD risk of India's population is limited. To inform health system planning and effective targeting of interventions, this study aimed to determine how CVD risk-and the factors that determine risk-varies among states in India, by rural-urban location, and by individual-level sociodemographic characteristics. METHODS AND FINDINGS: We used 2 large household surveys carried out between 2012 and 2014, which included a sample of 797,540 adults aged 30 to 74 years across India...
June 2018: PLoS Medicine
Ariela R Orkaby, Kathryn L Lunetta, Fangui J Sun, Jane A Driver, Emelia J Benjamin, Naomi M Hamburg, Gary F Mitchell, Ramachandran S Vasan, Joanne M Murabito
Background: Frailty is a risk factor for cardiovascular disease. Underlying mechanisms to explain the connection between frailty and cardiovascular disease are unclear. We sought to examine the association between frailty and arterial stiffness, a precursor of hypertension and cardiovascular disease. Methods: We conducted a cross-sectional analysis of community-dwelling Framingham Heart Study Offspring and Omni participants ≥60 years of age examined in 2005-2008...
June 18, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Dana Jorgensen, Gretchen E White, Akira Sekikawa, Peter Gianaros
Cardiovascular disease (CVD) may increase depression risk. Risk for future CVD, which can be estimated by the Framingham Risk Score (FRS), and depression risk are both linked to systemic inflammation. Dietary consumption of proinflammatory food can be measured using the Dietary Inflammatory Index (DII) score. We examined the potential impact of DII on depression and whether this effect is independent of FRS. We hypothesized that (1) both FRS and DII would be associated with depression (Patient Health Questionnaire-9 ≥ 10) and (2) associations between DII and depressive symptoms (continuous) would be mediated by FRS...
June 2018: Nutrition Research
José M Gatell, Lambert Assoumou, Graeme Moyle, Laura Waters, Margaret Johnson, Pere Domingo, Julie Fox, Esteban Martinez, Hans-Jürgen Stellbrink, Giovanni Guaraldi, Mar Masia, Mark Gompels, Stephane De Wit, Eric Florence, Stefan Esser, François Raffi, Christoph Stephan, Juergen Rockstroh, Andrea Giacomelli, Jaime Vera, José Ignacio Bernardino, Alan Winston, Maria Saumoy, Julien Gras, Christine Katlama, Anton L Pozniak
Background: Both immediate or deferred switching from a PI/r to DTG may improve lipid profile. Methods: NEAT022 is a European, open label, randomized, trial. HIV-infected adults ≥ 50 years or with a Framingham score ≥10% were eligible if HIV RNA < 50 copies/mL. Patients were randomized to switch the PI/r to DTG immediately (DTG-I) or to deferred switch at week 48 (DTG-D) . Week 96 end-points were: proportion of patients with HIV RNA < 50 copies/ml, percentage change of lipid fractions and adverse events...
June 14, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Sashi Niranjan Nair, Harish Kumar, Manoj Raveendran, V Usha Menon
Introduction: The benefits of treating subclinical hypothyroidism are currently under debate, prevention of adverse cardiac events purporting to be one of the main benefits. The effect of subclinical hypothyroidism on the cardiovascular health of the Indian sub-population is largely unknown. This study was designed to examine these effects and to help guide treatment of this disorder. Methods: A cross-sectional adult population survey was carried out in urban coastal area of central Kerala...
March 2018: Indian Journal of Endocrinology and Metabolism
Michael L Chuang, Philimon N Gona, Saadia Qazi, Rebecca M Musgrave, Caroline S Fox, Joseph M Massaro, Udo Hoffmann, Christopher J O'Donnell
BACKGROUND: We sought to determine whether increased aortic arch width (AAW) adds to standard Framingham risk factors and coronary artery calcium (CAC) for prediction of incident adverse cardiovascular disease (CVD) events in community-dwelling adults. METHODS AND RESULTS: A total of 3026 Framingham Heart Study Offspring and Third Generation cohort participants underwent noncontrast multidetector computed tomography from 2002 to 2005 to quantify CAC. We measured AAW as the distance between the centroids of the ascending and descending thoracic aorta, at the level of main pulmonary artery bifurcation or the right pulmonary artery...
June 16, 2018: Journal of the American Heart Association
Hsuan-Ping Lin, Siyouneh Baghdasarian, Martha R Singer, Melanie M Mott, M Loring Bradlee, Richard T Pickering, Lynn L Moore
Previous recommendations to limit dietary cholesterol intake have been eliminated for most adults. Questions remain about whether dietary cholesterol has adverse cardiovascular effects among individuals with impaired fasting glucose or diabetes (IFG/T2DM). We used data for 993 adults (40.9% female), ages 35⁻<65 years, with prevalent IFG/T2DM in the prospective Framingham Offspring Study to address this question. Dietary cholesterol was assessed using 3-day diet records at exams 3 and 5 and used to classify subjects into sex-specific tertiles of mean cholesterol intake...
June 14, 2018: Nutrients
Toshiaki Ohkuma, Toshiharu Ninomiya, Hirofumi Tomiyama, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Victor Aboyans, Akira Yamashina
BACKGROUND AND AIMS: The ankle-brachial index (ABI) is a predictor of cardiovascular disease (CVD) and premature death. However, few studies on this marker are available in the general Asian populations. This study aimed to investigate the association between ABI measured with oscillometry and the risk of these outcomes. METHODS: We conducted an individual participant data meta-analysis in 10,679 community-dwelling Japanese individuals without a history of CVD. The primary outcome was a composite of CVD events and all-cause mortality...
May 31, 2018: Atherosclerosis
Frida Dangardt, Marietta Charakida, Scott Chiesa, Devina Bhowruth, Alicja Rapala, Daniela Thurn, Franz Schaefer, John Deanfield, Rukshana Shroff
BACKGROUND: Patients with chronic kidney disease (CKD) are exposed to both traditional 'Framingham' and uremia related cardiovascular risk factors that drive atherosclerotic and arteriosclerotic disease, but these cannot be differentiated using conventional ultrasound. We used ultra-high-frequency ultrasound (UHFUS) to differentiate medial thickness (MT) from intimal thickness (IT) in CKD patients, identify their determinants and monitor their progression. METHODS: Fifty-four children and adolescents with CKD and 12 healthy controls underwent UHFUS measurements using 55-70MHz transducers in common carotid and dorsal pedal arteries...
2018: PloS One
Chao-Qiang Lai, Caren E Smith, Laurence D Parnell, Yu-Chi Lee, Dolores Corella, Paul Hopkins, Bertha A Hidalgo, Stella Aslibekyan, Michael A Province, Devin Absher, Donna K Arnett, Katherine L Tucker, Jose M Ordovas
Background: The putative functional variant -265T>C (rs5082) within the APOA2 promoter has shown consistent interactions with saturated fatty acid (SFA) intake to influence the risk of obesity. Objective: The aim of this study was to implement an integrative approach to characterize the molecular basis of this interaction. Design: We conducted an epigenome-wide scan on 80 participants carrying either the rs5082 CC or TT genotypes and consuming either a low-SFA (<22 g/d) or high-SFA diet (≥22 g/d), matched for age, sex, BMI, and diabetes status in the Boston Puerto Rican Health Study (BPRHS)...
June 12, 2018: American Journal of Clinical Nutrition
Seon Young Hwang, Jae Lan Shim, Dayun Kang, Jungsoon Choi
BACKGROUND: Although the association between periodontitis and cardiovascular disease (CVD) has been reported, whether periodontitis and poor oral health behavior influence CVD risk remains unclear. OBJECTIVE: The aim of this study was to examine whether periodontal disease and poor oral health behavior predict 10-year general CVD risk using the Framingham Risk Score. METHODS: Patients older than 30 years with no CVD history (n = 8370) were selected using cross-sectional study data from the Korean National Health and Nutrition Examination Survey in 2013 and 2014...
June 12, 2018: Journal of Cardiovascular Nursing
Francisco Antonio Helfenstein Fonseca, Maria Cristina de Oliveira Izar
No abstract text is available yet for this article.
May 2018: Arquivos Brasileiros de Cardiologia
Julio Cesar Acosta Navarro, Luiza Antoniazzi, Adriana Midori Oki, Maria Carlos Bonfim, Valeria Hong, Luiz Aparecido Bortolotto, Pedro Acosta-Cardenas, Valeria Sandrim, Marcio Hiroshi Miname, Raul Dias Dos Santos Filho
BACKGROUND: Recent studies have shown a lower prevalence of metabolic syndrome (MSyn) in vegetarians (VEG) despite the inconclusive evidence from others. OBJECTIVE: To verify the association between diet and other lifestyle characteristics and the prevalence of MSyn, cardiovascular risk factors (CRF), and Framingham Risk Score (FRS) in apparently healthy VEG and omnivorous (OMN) men. METHODS: In this cross-sectional study, 88 apparently healthy men ≥ 35 years, 44 VEG and 44 OMN, were assessed for anthropometric data, blood pressure, blood lipids, glucose, C-reactive protein (CRP) and FRS...
May 2018: Arquivos Brasileiros de Cardiologia
Daniel E Jonas, Shivani Reddy, Jennifer Cook Middleton, Colleen Barclay, Joshua Green, Claire Baker, Gary N Asher
Importance: Cardiovascular disease (CVD) is the leading cause of death in the United States. Objective: To review the evidence on screening asymptomatic adults for CVD risk using electrocardiography (ECG) to inform the US Preventive Services Task Force. Data Sources: MEDLINE, Cochrane Library, and trial registries through May 2017; references; experts; literature surveillance through April 4, 2018. Study Selection: English-language randomized clinical trials (RCTs); prospective cohort studies reporting reclassification, calibration, or discrimination that compared risk assessment using ECG plus traditional risk factors vs traditional risk factors alone...
June 12, 2018: JAMA: the Journal of the American Medical Association
Susan J Curry, Alex H Krist, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Martha Kubik, C Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng, John B Wong
Importance: Cardiovascular disease (CVD), which encompasses atherosclerotic conditions such as coronary heart disease, cerebrovascular disease, and peripheral arterial disease, is the most common cause of death among adults in the United States. Treatment to prevent CVD events by modifying risk factors is currently informed by CVD risk assessment with tools such as the Framingham Risk Score or the Pooled Cohort Equations, which stratify individual risk to inform treatment decisions. Objective: To update the 2012 US Preventive Services Task Force (USPSTF) recommendation on screening for coronary heart disease with electrocardiography (ECG)...
June 12, 2018: JAMA: the Journal of the American Medical Association
Rana Abu Farha, Eman Alefishat
Objectives: We sought to evaluate the effect of night shift working on increasing the risk of developing cardiovascular disease (CVD) using three different predictors. Methods: One hundred and forty adult Jordanian employees were recruited in this cross-sectional study. Demographic data, anthropometric parameters, and working patterns information were documented. Metabolic syndrome (MetS) was diagnosed, and atherogenic index of the plasma (AIP) and Framingham risk score were calculated...
May 2018: Oman Medical Journal
Susan Chadid, Martha R Singer, Bernard E Kreger, M Loring Bradlee, Lynn L Moore
BACKGROUND: Overweight and diabetes are known cancer risk factors. This study examines independent and combined effects of weight gain and metabolic dysfunction during middle-adult years on obesity-related cancer risk. METHODS: Subjects (n = 3850) aged 45-69 years at exams 3-5 in the Framingham Offspring Study were classified according to current and prior (~14 years earlier) weight status, interim weight change and prevalent metabolic dysfunction. Cancer risk among subjects who were overweight at baseline and remained overweight, as well as those who became overweight during follow-up, was compared with risk among normal-weight individuals...
June 13, 2018: British Journal of Cancer
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