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https://www.readbyqxmd.com/read/28631345/advantages-and-disadvantages-of-using-intravenous-tissue-plasminogen-activator-as-salvage-therapy-for-inoperable-heartware-thrombosis
#1
Robyn Basken, Charles M Bazzell, Richard Smith, Rajesh Janardhanan, Zain Khalpey
Device thrombosis is a devastating complication of left ventricular assist devices. The definitive treatment has been device exchange or explant. Evidence of increasing morbidity and mortality with device exchange has shifted strategies toward conservative management. In this report, we detail the use of thrombolytics as salvage therapy in a patient with an occlusive HeartWare ventricular assist device (HeartWare Inc., Framingham, MA) thrombus, resulting in long-term survival without further intervention.
June 19, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28627378/practical-risk-score-for-5-10-and-20-year-prediction-of-dementia-in%C3%A2-elderly-persons-framingham-heart-study
#2
Jinlei Li, Matthew Ogrodnik, Sherral Devine, Sanford Auerbach, Philip A Wolf, Rhoda Au
INTRODUCTION: With a rapidly aging population, general practitioners are confronting the challenge of how to determine those who are at greatest risk for dementia and potentially need more specialized follow-up to mitigate symptoms early in its course. We created a practical dementia risk score and provided individualized estimates of future dementia risk. METHODS: Using the Framingham Heart Study data, we built our prediction model using Cox proportional hazard models and developed a point system for the risk score and risk estimates...
June 13, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28625611/comparing-sf-36%C3%A2-scores-versus-biomarkers-to-predict-mortality-in-primary-cardiac-prevention-patients
#3
EDITORIAL
Rony Lahoud, Vasutakarn Chongthammakun, Yuping Wu, Nael Hawwa, Danielle M Brennan, Leslie Cho
BACKGROUND: Risk stratification plays an important role in evaluating patients with no known cardiovascular disease (CVD). Few studies have investigated health-related quality of life questionnaires such as the Medical Outcomes Study Short Form-36 (SF-36®) as predictive tools for mortality, particularly in direct comparison with biomarkers. Our objective is to measure the relative effectiveness of SF-36® scores in predicting mortality when compared to traditional and novel biomarkers in a primary prevention population...
June 15, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28621562/association-between-alcohol-consumption-trajectories-and-clinical-profiles-among-women-and-men-living-with-hiv
#4
Natalie E Kelso-Chichetto, Michael Plankey, Alison G Abraham, Nicole Ennis, Xinguang Chen, Robert Bolan, Robert L Cook
BACKGROUND: Alcohol use is common among persons living with HIV (PLWH). It is unclear how alcohol consumption changes over time and if these changes are associated with clinical profiles. OBJECTIVE: We aimed to describe the association between longitudinal patterns of alcohol consumption and the clinical profiles of PLWH. METHODS: Data from the Women's Interagency HIV Study (n = 1123 women) and Multicenter AIDS Cohort Study (n = 597 men) from 2004 to 2013 were utilized...
June 16, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28620545/cardiovascular-risk-factors-among-women-with-self-reported-infertility
#5
Shruthi Mahalingaiah, Fangui Sun, J Jojo Cheng, Erika T Chow, Kathryn L Lunetta, Joanne M Murabito
BACKGROUND: Amongst women with certain types of ovulatory disorder infertility, the studies are conflicting whether there is an increased risk of long-term cardiovascular disease risk. This paper evaluates the associations of several CVD risk factors among Framingham women with self-reported infertility. METHODS: Women who completed the Framingham Heart Study Third Generation and Omni Cohort 2 Exam 2 (2008-2011), and reported on past history of infertility and current cardiovascular disease status were included in this cross-sectional study...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/28619195/association-of-triglyceride-related-genetic-variants-with-mitral%C3%A2-annular%C3%A2-calcification
#6
Mehdi Afshar, Kevin Luk, Ron Do, Line Dufresne, David S Owens, Tamara B Harris, Gina M Peloso, Kathleen F Kerr, Quenna Wong, Albert V Smith, Mathew J Budoff, Jerome I Rotter, L Adrienne Cupples, Stephen S Rich, James C Engert, Vilmundur Gudnason, Christopher J O'Donnell, Wendy S Post, George Thanassoulis
BACKGROUND: Mitral annular calcium (MAC), commonly identified by cardiac imaging, is associated with cardiovascular events and predisposes to the development of clinically important mitral valve regurgitation and mitral valve stenosis. However, its biological determinants remain largely unknown. OBJECTIVES: The authors sought to evaluate whether a genetic predisposition to elevations in plasma lipids is associated with the presence of MAC. METHODS: The authors used 3 separate Mendelian randomization techniques to evaluate the associations of lipid genetic risk scores (GRS) with MAC in 3 large patient cohorts: the Framingham Health Study, MESA (Multiethnic European Study of Atherosclerosis), and the AGE-RS (Age, Gene/Environment Susceptibility-Reykjavik Study)...
June 20, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28616937/influence-of-arterial-hypertension-type-2-diabetes-and-cardiovascular-risk-factors-on-als-outcome-a-population-based-study
#7
Cristina Moglia, Andrea Calvo, Antonio Canosa, Davide Bertuzzo, Paolo Cugnasco, Luca Solero, Maurizio Grassano, Enrica Bersano, Stefania Cammarosano, Umberto Manera, Fabrizio Pisano, Letizia Mazzini, Laura A Dalla Vecchia, Gabriele Mora, Adriano Chiò
OBJECTIVE: To assess the prognostic influence of pre-morbid type 2 diabetes mellitus, arterial hypertension and cardiovascular (CV) risk profile on ALS phenotype and outcome in a population-based cohort of Italian patients. METHODS: A total of 650 ALS patients from the Piemonte/Valle d'Aosta Register for ALS, incident in the 2007-2011 period, were recruited. Information about premorbid presence of type 2 diabetes mellitus, arterial hypertension was collected at the time of diagnosis...
June 15, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28611898/utility-of-the-history-and-physical-examination-in-the-detection-of-acute-coronary-syndromes-in-emergency-department-patients
#8
REVIEW
Zachary Dw Dezman, Amal Mattu, Richard Body
Chest pain accounts for approximately 6% of all emergency department (ED) visits and is the most common reason for emergency hospital admission. One of the most serious diagnoses emergency physicians must consider is acute coronary syndrome (ACS). This is both common and serious, as ischemic heart disease remains the single biggest cause of death in the western world. The history and physical examination are cornerstones of our diagnostic approach in this patient group. Their importance is emphasized in guidelines, but there is little evidence to support their supposed association...
June 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28610624/normal-limits-of-the-electrocardiogram-derived-from-a-large-database-of-brazilian-primary-care-patients
#9
Daniel M F Palhares, Milena S Marcolino, Thales M M Santos, José L P da Silva, Paulo R Gomes, Leonardo B Ribeiro, Peter W Macfarlane, Antonio L P Ribeiro
BACKGROUND: Knowledge of the normal limits of the electrocardiogram (ECG) is mandatory for establishing which patients have abnormal ECGs. No studies have assessed the reference standards for a Latin American population. Our aim was to establish the normal ranges of the ECG for pediatric and adult Brazilian primary care patients. METHODS: This retrospective observational study assessed all the consecutive 12-lead digital electrocardiograms of primary care patients at least 1 year old in Minas Gerais state, Brazil, recorded between 2010 and 2015...
June 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28610589/high-sensitivity-cardiac-troponin-t-is-a-biomarker-for-atherosclerosis-in-systemic-lupus-erythematous-patients-a-cross-sectional-controlled-study
#10
Gillian Divard, Rachid Abbas, Camille Chenevier-Gobeaux, Noémie Chanson, Brigitte Escoubet, Marie-Paule Chauveheid, Antoine Dossier, Thomas Papo, Monique Dehoux, Karim Sacre
BACKGROUND: Cardiovascular disease (CVD) is the main cause of death in systemic lupus erythematous (SLE) patients. The Framingham score underestimates the risk for CVD in this population. Our study aimed to determine whether serum high-sensitivity cardiac troponin T (HS-cTnT) might help to identify SLE patients at risk for CVD. METHODS: The presence of carotid plaques was prospectively assessed by ultrasound in 63 consecutive SLE patients asymptomatic for CVD and 18 controls...
June 13, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28608963/relationship-between-lower-urinary-tract-symptoms-and-cardiovascular-risk-scores-including-framingham-risk-score-and-acc-aha-risk-score
#11
Bora Lee, Sang Wook Lee, Hye Rim Kang, Dae In Kim, Hwa Yeon Sun, Jae Heon Kim
AIMS: This study attempted to investigate the association between lower urinary tract symptoms (LUTS) and cardiovascular disease (CVD) risk using International Prostate Symptom Score (IPSS) and CVD risk scores and to overcome the limitations of previous relevant studies. METHODS: A total of 2994 ostensibly healthy males, who participated in a voluntary health check in a health promotion center from January 2010 to December 2014, were reviewed. CVD risk scores were calculated using Framingham risk score and American College of Cardiology (ACC)/American Heart Association (AHA) score...
June 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28608942/a-risk-score-model-for-predicting-risk-of-type-2-diabetes-mellitus-in-a-rural-chinese-adult-population-a-cohort-study-with-a-6-year-follow-up
#12
Hongyan Zhang, Chongjian Wang, Yongcheng Ren, Bingyuan Wang, Xiangyu Yang, Yang Zhao, Chengyi Han, Junmei Zhou, Lu Zhang, Minjie Qi, Yujia Zhai, Chao Pang, Lei Yin, Jingzhi Zhao, Dongsheng Hu, Ming Zhang
BACKGROUND: Several prediction tools have been developed to identify people with T2DM and to quantify the probability of developing T2DM. However, most of the risk models were constructed based on cross-sectional studies and tea-drinking was not included. METHODS: A total of 15,768 participants without known T2DM were followed up from 2007-2008 to 2013-2014; 12,654 were randomly assigned to the derivation dataset and 3114 to the validation dataset. We constructed a risk-score model for T2DM by using a Cox proportional-hazards model...
June 13, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28606059/observed-versus-predicted-cardiovascular-events-and-all-cause-death-in-hiv-infection-a-longitudinal-cohort-study
#13
Giuseppe Vittorio De Socio, Giacomo Pucci, Franco Baldelli, Giuseppe Schillaci
BACKGROUND: The aim of the study was to assess the applicability of an algorithm predicting 10-year cardiovascular disease (CVD) generated in the setting of the Framingham Heart Study to a real-life, contemporary Italian cohort of HIV-positive subjects. METHODS: The study was an observational longitudinal cohort study. The probability for 10-year CVD events according to the Framingham algorithm was assessed in 369 consecutive HIV-positive participants free from overt CVD enrolled in 2004, who were followed for a median of 10...
June 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28605427/residential-proximity-to-major-roadways-fine-particulate-matter-and-hepatic-steatosis-the-framingham-heart-study
#14
Wenyuan Li, Kirsten S Dorans, Elissa H Wilker, Mary B Rice, Michelle T Long, Joel Schwartz, Brent A Coull, Petros Koutrakis, Diane R Gold, Caroline S Fox, Murray A Mittleman
No abstract text is available yet for this article.
June 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28602601/association-of-amine-biomarkers-with-incident-dementia-and-alzheimer-s-disease-in-the-framingham-study
#15
Vincent Chouraki, Sarah R Preis, Qiong Yang, Alexa Beiser, Shuo Li, Martin G Larson, Galit Weinstein, Thomas J Wang, Robert E Gerszten, Ramachandran S Vasan, Sudha Seshadri
INTRODUCTION: The identification of novel biomarkers associated with Alzheimer's disease (AD) could provide key biological insights and permit targeted preclinical prevention. We investigated circulating metabolites associated with incident dementia and AD using metabolomics. METHODS: Plasma levels of 217 metabolites were assessed in 2067 dementia-free Framingham Offspring Cohort participants (mean age = 55.9 ± 9.7 years; 52.4% women). We studied their associations with future dementia and AD risk in multivariate Cox models...
June 8, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28602543/reduction-in-cardiovascular-risk-among-latino-participants-in-a-community-based-intervention-linked-with-clinical-care
#16
Mori J Krantz, Brenda Beaty, Stephanie Coronel-Mockler, Bonnie Leeman-Castillo, Kelly Fletcher, Raymond O Estacio
INTRODUCTION: Community Heart Health Actions for Latinos at Risk is a community health worker-led cardiovascular disease risk reduction program targeting low-income urban Latinos. The impact of community programs linked with clinical care has not been well characterized. METHODS: Community Heart Health Actions for Latinos at Risk provided 12 weeks of lifestyle education. Changes in risk factors were assessed before and after completion. Univariate, bivariate, and multivariate analyses were used to determine factors associated with changes in risk factors...
June 8, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28602434/carotid-plaque-thickness-and-common-carotid-imt-show-additive-value-in-cardiovascular-risk-prediction-and-reclassification
#17
Mauro Amato, Fabrizio Veglia, Ulf de Faire, Philippe Giral, Rainer Rauramaa, Andries J Smit, Sudhir Kurl, Alessio Ravani, Beatrice Frigerio, Daniela Sansaro, Alice Bonomi, Calogero C Tedesco, Samuela Castelnuovo, Elmo Mannarino, Steve E Humphries, Anders Hamsten, Elena Tremoli, Damiano Baldassarre
BACKGROUND AND AIMS: Carotid plaque size and the mean common carotid intima-media thickness measured in plaque-free areas (PF CC-IMTmean) have been identified as predictors of vascular events (VEs), but their complementarity in risk prediction and stratification is still unresolved. The aim of this study was to evaluate the independence of carotid plaque thickness and PF CC-IMTmean in cardiovascular risk prediction and risk stratification. METHODS: The IMPROVE-study is a European cohort (n = 3703), where the thickness of the largest plaque detected in the whole carotid tree was indexed as cIMTmax...
May 19, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28600367/development-and-validation-of-a-risk-stratification-model-for-prediction-of-disability-and-hospitalisation-in-patients-with-heart-failure-a-study-protocol
#18
Luis García-Olmos, Francisco Rodríguez-Salvanés, Maurice Batlle-Pérez, Río Aguilar-Torres, Carlos Porro-Fernández, Alfredo García-Cabello, Montserrat Carmona, Sergio Ruiz-Alonso, Sofía Garrido-Elustondo, Ángel Alberquilla, Luis María Sánchez-Gómez, Ricardo Sánchez de Madariaga, Elena Monge-Navarrete, Luis Benito-Ortiz, Nicolás Baños-Pérez, Amaya Simón-Puerta, Ana Belén López Rodríguez, Miguel Ángel Martínez-Álvarez, María Ángeles Velilla-Celma, María Isabel Bernal-Gómez
BACKGROUND: Chronic heart failure (CHF) reduces quality of life and causes hospitalisation and death. Identifying predictive factors of such events may help change the natural history of this condition. AIM: To develop and validate a stratification system for classifying patients with CHF, according to their degree of disability and need for hospitalisation due to any unscheduled cause, over a period of 1 year. METHODS AND ANALYSIS: Prospective, concurrent, cohort-type study in two towns in the Madrid autonomous region having a combined population of 1 32 851...
June 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28600161/a-problem-solving-intervention-for-cardiovascular-disease-risk-reduction-in-veterans-protocol-for-a-randomized-controlled-trial
#19
Jason A Nieuwsma, Laura O Wray, Corrine I Voils, Jennifer M Gierisch, Margaret Dundon, Cynthia J Coffman, George L Jackson, Rhonda Merwin, Christina Vair, Karen Juntilla, Courtney White-Clark, Amy S Jeffreys, Amy Harris, Michael Owings, Johnpatrick Marr, David Edelman
BACKGROUND: Health behaviors related to diet, tobacco usage, physical activity, medication adherence, and alcohol use are highly determinative of risk for developing cardiovascular disease. This paper describes a study protocol to evaluate a problem-solving intervention that aims to help patients at risk for developing cardiovascular disease address barriers to adopting positive health behaviors in order to reduce cardiovascular risk. METHODS: Eligible patients are adults enrolled in Veterans Affairs (VA) health care who have not experienced a cardiovascular event but are at elevated risk based on their Framingham Risk Score (FRS)...
June 6, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28597569/cross-sectional-relations-of-whole-blood-mirna-expression-levels-and-hand-grip-strength-in-a-community-sample
#20
Joanne M Murabito, Jian Rong, Kathryn L Lunetta, Tianxiao Huan, Honghuang Lin, Qiang Zhao, Jane E Freedman, Kahraman Tanriverdi, Daniel Levy, Martin G Larson
MicroRNAs (miRNAs) regulate gene expression with emerging data suggesting miRNAs play a role in skeletal muscle biology. We sought to examine the association of miRNAs with grip strength in a community-based sample. Framingham Heart Study Offspring and Generation 3 participants (n = 5668 54% women, mean age 55 years, range 24, 90 years) underwent grip strength measurement and miRNA profiling using whole blood from fasting morning samples. Linear mixed-effects regression modeling of grip strength (kg) versus continuous miRNA 'Cq' values and versus binary miRNA expression was performed...
June 8, 2017: Aging Cell
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