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https://www.readbyqxmd.com/read/29024045/association-between-dietary-fiber-intake-and-bone-loss-in-the-framingham-offspring-study
#1
Zhaoli Dai, Yuqing Zhang, Na Lu, David T Felson, Douglas P Kiel, Shivani Sahni
Dietary fiber may increase calcium absorption, but its role in bone mineralization is unclear. Furthermore, the health effect of dietary fiber may be different between genders. We examined the association between dietary fiber (total fiber and fiber from cereal, fruits, vegetables, nuts and legumes) and bone loss at the femoral neck, trochanter and lumbar spine (L2-4) in older men and women. In the Framingham Offspring Study, at baseline (1996-2001), diet was assessed using the Willett food frequency questionnaire and bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry...
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29020908/cardiac-society-of-australia-and-new-zealand-position-statement-executive-summary-coronary-artery-calcium-scoring
#2
Christian R Hamilton-Craig, Clara K Chow, John F Younger, V M Jelinek, Jonathan Chan, Gary Yh Liew
Introduction This article summarises the Cardiac Society of Australia and New Zealand position statement on coronary artery calcium (CAC) scoring. CAC scoring is a non-invasive method for quantifying coronary artery calcification using computed tomography. It is a marker of atherosclerotic plaque burden and the strongest independent predictor of future myocardial infarction and mortality. CAC scoring provides incremental risk information beyond traditional risk calculators such as the Framingham Risk Score...
October 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29020384/fibrosis-as-measured-by-the-biomarker-tissue-inhibitor-metalloproteinase-1-predicts-mortality-in-age-gene-environment-susceptibility-reykjavik-ages-reykjavik-study
#3
Gina LaRocca, Thor Aspelund, Anders M Greve, Gudny Eiriksdottir, Tushar Acharya, Gudmundur Thorgeirsson, Tamara B Harris, Lenore J Launer, Vilmundur Gudnason, Andrew E Arai
Background: Fibrosis is a key pathological process in many chronic inflammatory disease states. Aims: We hypothesized that tissue inhibitor metalloproteinase-1 and matrix metalloproteinase-9 (TIMP-1 and MMP-9), biomarkers of fibrosis, would predict all-cause mortality and we assessed the incremental value of these biomarkers when adjusting for clinical and other biomarkers. Methods: The cohort included 5511 community-dwelling participants in the AGES-Reykjavik Study...
August 29, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28993952/discordance-of-the-framingham-cardiovascular-risk-score-and-the-2013-american-college-of-cardiology-american-heart-association-risk-score-in-systemic-lupus-erythematosus-and-rheumatoid-arthritis
#4
Kashif Jafri, Alexis Ogdie, Atif Qasim, Sarah L Patterson, Milena Gianfrancesco, Zara Izadi, Patricia Katz, Jinoos Yazdany, Gabriela Schmajuk
Despite the increasing use of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) cardiovascular (CV) risk score in clinical practice, few studies have compared this score to the Framingham risk score among rheumatologic patients. We calculated Framingham and 2013 ACC/AHA risk scores in subjects with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and assessed demographic, CV, and rheumatologic characteristics associated with discordant scores (high-risk ACC/AHA scores but low-risk Framingham scores)...
October 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28993406/heritability-of-mitral-regurgitation-observations-from-the-framingham-heart-study-and-swedish-population
#5
Francesca N Delling, Xinjun Li, Shuo Li, Qiong Yang, Vanessa Xanthakis, Andreas Martinsson, Pontus Andell, Birgitta T Lehman, Ewa W Osypiuk, Plamen Stantchev, Bengt Zöller, Emelia J Benjamin, Kristina Sundquist, Ramachandran S Vasan, J Gustav Smith
BACKGROUND: Familial aggregation has been described for primary mitral regurgitation (MR) caused by mitral valve prolapse. We hypothesized that heritability of MR exists across different MR subtypes including nonprimary MR. METHODS AND RESULTS: Study participants were FHS (Framingham Heart Study) Generation 3 (Gen 3) and Gen 2 cohort participants and all adult Swedish siblings born after 1932 identified in 1997 and followed through 2010. MR was defined as ≥ mild regurgitation on color Doppler in FHS and from International Classification of Diseases codes in Sweden...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28993255/relations-of-mitochondrial-genetic-variants-to-measures-of-vascular-function
#6
Jessica L Fetterman, Chunyu Liu, Gary F Mitchell, Ramachandran S Vasan, Emelia J Benjamin, Joseph A Vita, Naomi M Hamburg, Daniel Levy
Mitochondrial genetic variation with resultant alterations in oxidative phosphorylation may influence vascular function and contribute to cardiovascular disease susceptibility. We assessed relations of peptide-encoding variants in the mitochondrial genome with measures of vascular function in Framingham Heart Study participants. Of 258 variants assessed, 40 were predicted to have functional consequences by bioinformatics programs. A maternal pattern of heritability was estimated to contribute to the variability of aortic stiffness...
October 6, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28991599/examination-of-a-nurse-led-community-based-education-and-coaching-intervention-for-coronary-heart-disease-high-risk-individuals-in-china
#7
Yan-Jin Huang, Monica Parry, Ying Zeng, Yan Luo, Jing Yang, Guo-Ping He
PURPOSE: Early detection and management of coronary heart disease (CHD) are embedded into many community health service and primary care practices in western countries. The Framingham CHD risk score has been used to predict CHD and mortality for nearly 20 years, and it has predicted CHD event risk accurately in multiethnic populations. The aim of this study was to access the effect of a 6-month community-based intervention on CHD risk in individuals at high risk. METHODS: A randomized controlled trial of individuals with a high 10-year CHD risk were recruited from two communities in China...
September 2017: Asian Nursing Research
https://www.readbyqxmd.com/read/28990165/framingham-based-cardiovascular-risk-estimates-among-people-with-episodic-migraine-in-the-us-population-results-from-the-american-migraine-prevalence-and-prevention-ampp-study
#8
Richard B Lipton, Michael L Reed, Tobias Kurth, Kristina M Fanning, Dawn C Buse
BACKGROUND: Cardiovascular (CV) events, conditions, and procedures (ECPs) are common in persons with migraine and are a contraindication to triptan and ergot use. In a prior study, we estimated that there are 2.6 million American adults with episodic migraine (EM) who have had CV ECPs. However, the prior analysis did not assess persons with migraine without CV ECPs who are at high risk for a first cardiovascular disease (CVD) event. OBJECTIVES: To use the Framingham nonlaboratory CVD events risk equation to estimate the number of individuals with EM who are at elevated risk for a first CVD event in the next 10 years using data from the American Migraine Prevalence and Prevention Study, and then to extrapolate the findings to the US population to estimate the scope of people with EM for whom triptan and ergot therapies may be problematic...
October 9, 2017: Headache
https://www.readbyqxmd.com/read/28986242/rethinking-optimization-methods-identified-optimal-risk-thresholds-for-preventive-treatment-an-illustration-in-coronary-heart-disease
#9
A van Giessen, G A de Wit, K G M Moons, J A N Dorresteijn, H Koffijberg
INTRODUCTION: Treatment thresholds based on risk predictions can be optimized by considering various health (economic) outcomes and performing marginal analyses, but this is rarely performed. We demonstrate a general approach to identify treatment thresholds optimizing individual health (economic) outcomes, illustrated for statin treatment based on 10-year coronary heart disease (CHD) risk predicted by the Framingham risk score. METHODS: Creating a health economic model for a risk-based prevention strategy, risk thresholds can be evaluated on several outcomes of interest...
October 3, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28986063/utility-of-the-0-hour-1-hour-high-sensitivity-cardiac-troponin-t-algorithm-in-asian-patients-with-suspected-non-st-elevation-myocardial-infarction
#10
Masayuki Shiozaki, Kenji Inoue, Satoru Suwa, Chien-Chang Lee, Yuichi Chikata, Junko Ishiura, Yuki Kimura, Kentaro Fukuda, Hiroshi Tamura, Yasumasa Fujiwara, Masataka Sumiyoshi, Hiroyuki Daida
BACKGROUND: A rapid rule-out or rule-in protocol based on the 0-hour/1-hour algorithm using high-sensitivity cardiac troponin T is recommended by the European Society of Cardiology. However, Asian data are not available. METHODS: This prospective cohort study included 413 patients with suspected non-ST elevation myocardial infarction in 3 hospitals in Japan and Taiwan from November 2014 to April 2017. Patients were divided into 3groups-rule-out, observe, and rule-in-according to the algorithm...
September 30, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28984639/baseline-white-matter-hyperintensities-and-hippocampal-volume-are-associated-with-conversion-from-normal-cognition-to-mild-cognitive-impairment-in-the-framingham-offspring-study
#11
Katherine J Bangen, Sarah R Preis, Lisa Delano-Wood, Philip A Wolf, David J Libon, Mark W Bondi, Rhoda Au, Charles DeCarli, Adam M Brickman
INTRODUCTION: We examined associations between magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration with mild cognitive impairment (MCI) diagnosis at baseline and conversion from normal cognition to MCI at follow-up. METHODS: Framingham Offspring participants underwent brain MRI and neuropsychological assessment at baseline (n=1049) and follow-up (n=561). Participants were classified at baseline and at follow-up as cognitively normal or MCI using sensitive neuropsychological criteria...
October 3, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28981492/an-observational-study-of-how-clinicians-use-cardiovascular-risk-assessment-to-inform-statin-prescribing-decisions
#12
Thomas Robinson, Rod Jackson, Susan Wells, Andrew Kerr, Roger Marshall
AIM: Cardiovascular disease (CVD) risk assessment is commonly recommended in guidelines, but there is uncertainty about how clinicians use this information. Our objective was to understand how New Zealand primary care clinicians use CVD risk assessment estimates to inform new statin prescribing. METHODS: We used a cohort of patients seen in primary care who have had a CVD risk estimated on the basis of a New Zealand modified Framingham risk equation. These patients were linked to national pharmaceutical dispensing records to determine new statin use in the following six months...
October 6, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28979779/a-clinical-genetic-approach-to-assessing-cardiovascular-risk-in-patients-with-ckd
#13
Emilio Rodrigo, Sara Pich, Isaac Subirana, Gema Fernandez-Fresnedo, Paloma Barreda, Carles Ferrer-Costa, Ángel Luis M de Francisco, Eduardo Salas, Roberto Elosua, Manuel Arias
BACKGROUND: Coronary heart disease (CHD) is the primary cause of death in individuals with chronic kidney disease (CKD), but current equations for assessing coronary risk have low accuracy in this group. We have reported that the addition of a genetic risk score (GRS) to the Framingham risk function improved its predictive capacity in the general population. The aims of this study were to evaluate the association between this GRS and coronary events in the CKD population and to determine whether the addition of the GRS to coronary risk prediction functions improves the estimation of coronary risk at the earliest possible stages of kidney disease...
October 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28977464/measures-of-biologic-age-in-a-community-sample-predict-mortality-and-age-related-disease-the-framingham-offspring-study
#14
Joanne M Murabito, Qiang Zhao, Martin G Larson, Jian Rong, Honghuang Lin, Emelia J Benjamin, Daniel Levy, Kathryn L Lunetta
Background: We tested the association of biologic age (BA) measures constructed from different types of biomarkers with mortality and disease in a community-based sample. Methods: In Framingham Offspring participants at Exams 7 (1998-2001, mean age 62 ± 10) and 8 (2005-2008, mean age 67 ± 9), we used the Klemera-Doubal method to estimate clinical BA and inflammatory BA and computed the difference (∆age) between BA and CA. Clinical ∆age was computed at Exam 2 (1979-1983, mean age 45 ± 10)...
July 25, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28977374/incremental-prognostic-value-of-coronary-computed-tomography-angiography-over-coronary-calcium-scoring-for-major-adverse-cardiac-events-in-elderly-asymptomatic-individuals
#15
Donghee Han, Bríain Ó Hartaigh, Heidi Gransar, Ji Hyun Lee, Asim Rizvi, Lohendran Baskaran, Joshua Schulman-Marcus, Allison Dunning, Stephan Achenbach, Mouaz H Al-Mallah, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Erica Maffei, Tracy Q Callister, Kavitha Chinnaiyan, Benjamin J W Chow, Augustin DeLago, Martin Hadamitzky, Joerg Hausleiter, Philipp A Kaufmann, Gilbert Raff, Leslee J Shaw, Todd C Villines, Yong-Jin Kim, Jonathon Leipsic, Gudrun Feuchtner, Ricardo C Cury, Gianluca Pontone, Daniele Andreini, Hugo Marques, Ronen Rubinshtein, Niree Hindoyan, Erica C Jones, Millie Gomez, Fay Y Lin, Hyuk-Jae Chang, James K Min
Aims: Coronary computed tomography angiography (CCTA) and coronary artery calcium score (CACS) have prognostic value for coronary artery disease (CAD) events beyond traditional risk assessment. Age is a risk factor with very high weight and little is known regarding the incremental value of CCTA over CAC for predicting cardiac events in older adults. Methods and results: Of 27 125 individuals undergoing CCTA, a total of 3145 asymptomatic adults were identified...
July 20, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28975197/association-of-multiorgan-computed-tomographic-phenomap-with-adverse-cardiovascular-health-outcomes-the-framingham-heart-study
#16
Ravi V Shah, Ashish S Yeri, Venkatesh L Murthy, Joe M Massaro, Ralph D'Agostino, Jane E Freedman, Michelle T Long, Caroline S Fox, Saumya Das, Emelia J Benjamin, Ramachandran S Vasan, Christopher J O'Donnell, Udo Hoffmann
Importance: Increased ability to quantify anatomical phenotypes across multiple organs provides the opportunity to assess their cumulative ability to identify individuals at greatest susceptibility for adverse outcomes. Objective: To apply unsupervised machine learning to define the distribution and prognostic importance of computed tomography-based multiorgan phenotypes associated with adverse health outcomes. Design, Setting, and Participants: This asymptomatic community-based cohort study included 2924 Framingham Heart Study participants between July 2002 and April 2005 undergoing computed tomographic imaging of the chest and abdomen...
September 20, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28973115/effect-of-a-game-based-intervention-designed-to-enhance-social-incentives-to-increase-physical-activity-among-families-the-be-fit-randomized-clinical-trial
#17
Mitesh S Patel, Emelia J Benjamin, Kevin G Volpp, Caroline S Fox, Dylan S Small, Joseph M Massaro, Jane J Lee, Victoria Hilbert, Maureen Valentino, Devon H Taylor, Emily S Manders, Karen Mutalik, Jingsan Zhu, Wenli Wang, Joanne M Murabito
Importance: Gamification, the application of game design elements such as points and levels in nongame contexts, is often used in digital health interventions, but evidence on its effectiveness is limited. Objective: To test the effectiveness of a gamification intervention designed using insights from behavioral economics to enhance social incentives within families to increase physical activity. Design, Setting, and Participants: The Behavioral Economics Framingham Incentive Trial (BE FIT) was a randomized clinical trial with a 12-week intervention period and a 12-week follow-up period...
October 2, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28971303/laparoscopic-roux-en-y-gastric-bypass-improves-lipid-profile-and-decreases-cardiovascular-risk-a-5-year-longitudinal-cohort-study-of-1048-patients
#18
Daniel Gero, Lucie Favre, Pierre Allemann, Pierre Fournier, Nicolas Demartines, Michel Suter
BACKGROUND: Dyslipidemia is a known risk factor for cardiovascular (CV) events. The aim of the study was to assess lipid profiles and their impact on CV risk changes in a large patient cohort 5 years after Roux-en-Y gastric bypass (RYGB). METHODS: All patients who underwent primary RYGB for severe obesity in our two hospitals between January 1999 and December 2009 were included. The Framingham risk score was used. RESULTS: One thousand and forty-eight patients were included, 791 women and 257 men...
October 2, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28968808/assessment-of-the-frequency-of-cardiovascular-risk-factors-in-patients-with-takayasu-s-arteritis
#19
Fatma Alibaz-Oner, Matthew J Koster, Ali U Unal, Hale G Yildirim, Ceylan Çikikçi, Jean Schmidt, Cynthia S Crowson, Ashima Makol, Steven R Ytterberg, Eric L Matteson, Haner Direskeneli, Kenneth J Warrington
Objectives: The prevalence of atherosclerotic risk factors and disease in Takayasu's arteritis (TAK) has not been well defined. We aimed to assess the frequency of cardiovascular (CV) risk factors and the incidence of CV events (CVEs) in patients with TAK from two ethnically different populations. Methods: Patients with TAK followed at Mayo Clinic, Rochester, MN, USA and Marmara University, Istanbul, Turkey were included in this retrospective study. Patients with TAK were compared with age-, sex- and calendar year-matched controls from the same geographical region without TAK...
August 9, 2017: Rheumatology
https://www.readbyqxmd.com/read/28965712/relation-between-a-simple-lifestyle-risk-score-and-established-biological-risk-factors-for-cardiovascular-disease
#20
Valérie Lévesque, Paul Poirier, Jean-Pierre Després, Natalie Alméras
Although cardiovascular disease (CVD) and diabetes mellitus are largely lifestyle driven, lifestyle metrics are not used in clinical practice. This study examined the relevance of using a simple lifestyle risk score designed for primary care medicine by testing its ability to predict biological CVD risk factors in a cohort of 3,712 individuals involved in a workplace health evaluation or management program ("Grand Défi Entreprise" project). Using a lifestyle risk score based on waist circumference, fitness, nutritional quality, and physical activity level, employees were categorized into 3 distinct estimated lifestyle risk levels (low, intermediate, and high)...
August 30, 2017: American Journal of Cardiology
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