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https://www.readbyqxmd.com/read/28228567/prolonged-sleep-duration-as-a-marker-of-early-neurodegeneration-predicting-incident-dementia
#1
Andrew J Westwood, Alexa Beiser, Nikita Jain, Jayandra J Himali, Charles DeCarli, Sanford H Auerbach, Matthew P Pase, Sudha Seshadri
OBJECTIVE: To evaluate the association between sleep duration and the risk of incident dementia and brain aging. METHODS: Self-reported total hours of sleep were examined in the Framingham Heart Study (n = 2,457, mean age 72 ± 6 years, 57% women) as a 3-level variable: <6 hours (short), 6-9 hours (reference), and >9 hours (long), and was related to the risk of incident dementia over 10 years, and cross-sectionally to total cerebral brain volume (TCBV) and cognitive performance...
February 22, 2017: Neurology
https://www.readbyqxmd.com/read/28225988/estimation-of-cardiovascular-risk-and-detection-of-subclinical-carotid-atheromatosis-in-patients-with-diabetes-without-a-history-of-cardiovascular-disease
#2
Walter Masson, Salvador De Francesca, Micaela Molinero, Daniel Siniawski, Andrés Mulassi, Frank Espinoza Morales, Melina Huerin, Martín Lobo, Graciela Molinero
Objectives: Cardiovascular risk estimated by several scores in patients with diabetes mellitus without a cardiovascular disease history and the association with carotid atherosclerotic plaque (CAP) were the aims of this study. Materials and methods: Cardiovascular risk was calculate using United Kingdom Prospective Diabetes Study (UKPDS) risk engine, Framingham risk score for cardiovascular (FSCV) and coronary disease (FSCD), and the new score (NS) proposed by the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28224927/an-age-and-sex-specific-gene-expression-score-is-associated-with-revascularization-and-coronary-artery-disease-insights-from-the-prospective-multicenter-imaging-study-for-evaluation-of-chest-pain-promise-trial
#3
Deepak Voora, Adrian Coles, Kerry L Lee, Udo Hoffmann, James A Wingrove, Brian Rhees, Lin Huang, Susan E Daniels, Mark Monane, Steven Rosenberg, Svati H Shah, William E Kraus, Geoffrey S Ginsburg, Pamela S Douglas
BACKGROUND: Identifying predictors of coronary artery disease (CAD)-related procedures and events remains a priority. METHODS: We measured an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive CAD (oCAD) in symptomatic nondiabetic patients in the PROMISE trial. The outcomes were oCAD (≥70% stenosis in ≥1 vessel or ≥50% left main stenosis on CT angiography [CTA]) and a composite endpoint of death, myocardial infarction, revascularization, or unstable angina...
February 2017: American Heart Journal
https://www.readbyqxmd.com/read/28224759/genomic-variants-at-20p11-associated-with-body-fat-mass-in-the-european-population
#4
Yu-Fang Pei, Hai-Gang Ren, Lu Liu, Xiao Li, Chen Fang, Yun Huang, Wen-Zhu Hu, Wei-Wen Kong, An-Ping Feng, Xin-Yi You, Wen Zhao, Hui Shen, Qing Tian, Yong-Hong Zhang, Hong-Wen Deng, Lei Zhang
OBJECTIVE: Body fat mass (BFM) is more homogeneous and accurate than body total mass in measuring obesity but has rarely been studied. Aiming to uncover the genetic basis of fat-induced obesity, a genome-wide association meta-analysis of BFM, after adjustment by body lean mass, was performed in the European population. METHODS: Three samples of European ancestry were included in the meta-analysis: the Framingham Heart Study (N = 6,004), the Kansas City osteoporosis study (N = 2,207), and the Omaha osteoporosis study (N = 968)...
February 22, 2017: Obesity
https://www.readbyqxmd.com/read/28222629/relationship-between-hyperuricemia-and-risk-of-coronary-heart-disease-in-a-middle-aged-and-elderly-chinese-population
#5
Ye Yang, Jian Tian, Chao Zeng, Jie Wei, Liang-Jun Li, Xi Xie, Tuo Yang, Hui Li, Guang-Hua Lei
Objective To investigate the relationship between hyperuricemia and coronary heart disease (CHD) risk based on the Framingham risk score (FRS) in a middle-aged and elderly Chinese population. Methods This cross-sectional study enrolled patients undergoing routine check-ups at Xiangya Hospital between October 2013 and November 2014. Hyperuricemia was defined as uric acid ≥416 mmol/l for males and ≥360 mmol/l for females. A 10-year CHD risk was calculated from FRS. A multivariable logistic analysis model was used to evaluate associations...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28219666/relation-of-iliac-artery-calcium-with-adiposity-measures-and-peripheral-artery-disease
#6
Jane J Lee, Alison Pedley, Ido Weinberg, Kathryn A Britton, Joseph M Massaro, Udo Hoffmann, Emily Manders, Caroline S Fox, Joanne M Murabito
Arterial calcification is associated with cardiovascular morbidity and mortality. To improve the understanding of the pathogenesis involved with iliac artery calcium (IAC), we sought to examine the associations between the burden of IAC with adiposity measures and peripheral artery disease (PAD). Participants (n = 1,236, 52% women, mean age 60 years) were drawn from the Framingham Heart Study Offspring cohort who underwent multidetector computed tomography. The extent of IAC was quantified based on calcified atherosclerotic plaques detected in the iliac arteries...
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28217978/the-association-of-chronic-kidney-disease-and-microalbuminuria-with-heart-failure-with-preserved-vs-reduced-ejection-fraction
#7
Matthew Nayor, Martin G Larson, Na Wang, Rajalakshmi Santhanakrishnan, Douglas S Lee, Connie W Tsao, Susan Cheng, Emelia J Benjamin, Ramachandran S Vasan, Daniel Levy, Caroline S Fox, Jennifer E Ho
AIMS: Chronic kidney disease (CKD) and microalbuminuria are associated with incident heart failure (HF), but their relative contributions to HF with preserved vs. reduced EF (HFpEF and HFrEF) are unknown. We sought to evaluate the associations of CKD and microalbuminuria with incident HF subtypes in the community-based Framingham Heart Study (FHS). METHODS AND RESULTS: We defined CKD as glomerular filtration rate <60 mL/min/1.73 m(2) , and microalbuminuria as a urine albumin to creatinine ratio (UACR) ≥17 mg/g in men and ≥25 mg/g in women...
February 20, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28216633/pentraxin-3-ficolin-2-and-lectin-pathway-associated-serine-protease-masp-3-as-early-predictors-of-myocardial-infarction-the-hunt2-study
#8
Inga Thorsen Vengen, Tone Bull Enger, Vibeke Videm, Peter Garred
The lectin complement pathway is suggested to play a role in atherogenesis. Pentraxin-3 (PTX3), ficolin-1, ficolin-2, ficolin-3, MBL/ficolin/collectin-associated serine protease-3 (MASP-3) and MBL/ficolin/collectin-associated protein-1 (MAP-1) are molecules related to activation of the lectin complement pathway. We hypothesized that serum levels of these molecules may be associated with the incidence of myocardial infarction (MI). In a Norwegian population-based cohort (HUNT2) where young to middle-aged relatively healthy Caucasians were followed up for a first-time MI from 1995-1997 through 2008, the 370 youngest MI patients were matched by age (range 29-62 years) and gender to 370 controls...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28214752/metabolic-syndrome-and-cardiovascular-risk-among-institutionalized-patients-with-schizophrenia-receiving-long-term-tertiary-care
#9
Lee Seng Esmond Seow, Siow Ann Chong, Peizhi Wang, Saleha Shafie, Hui Lin Ong, Mythily Subramaniam
BACKGROUND: Metabolic syndrome (MetS) and cardiovascular risk are highly prevalent among individuals with schizophrenia. This study aimed to determine the cardiometabolic profile and the associated risk factors in a group of institutionalized patients with schizophrenia or schizoaffective disorder receiving prolonged hospital care in the only tertiary psychiatric institution in Singapore. METHODS: Patients residing in long stay wards who were hospitalized for a minimum period of 1year were recruited...
February 2, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28191541/metabolic-acidosis-status-and-mortality-in-patients-on-the-end-stage-of-renal-disease
#10
Vaia D Raikou
BACKGROUND AND OBJECTIVES: Uncorrected metabolic acidosis leads to higher death risk in dialysis patients. We observed the relationship between metabolic acidosis status and mortality rate in patients on renal replacement therapy during a median follow up time of 60 months. METHODS: We studied 76 patients on an on-line hemodiafiltration. The dialysis adequacy was defined by Kt/V for urea. The Framingham risk score (FRS) points were used to determine the 10-year risk for coronary heart disease...
December 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28185105/evaluation-of-the-framingham-heart-study-risk-factors-and-risk-score-for-incident-chronic-kidney-disease-at-10%C3%A2-years-in-a-thai-general-population
#11
Krittika Saranburut, Prin Vathesatogkit, Anchalee Chittamma, Somlak Vanavanan, Nisakron Thongmung, Tuangrat Tangstheanphan, Piyamitr Sritara, Chagriya Kitiyakara
PURPOSE: Asians have some of the highest rates of end-stage renal disease, but there is limited information on the risk factors for chronic kidney disease (CKD) in the Asian general population. A risk score for incident CKD for the general population has been developed from the US Framingham Heart Study (FHS) Offspring cohort. This score has been validated on Caucasians and African-Americans, but has not been tested on Asians. We aimed to assess the importance of the FHS risk factors and the performance of the FHS risk score in predicting incident CKD at 10 years in a Thai community-based population...
February 9, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28184203/prefrontal-parietal-white-matter-volumes-in-healthy-elderlies-are-decreased-in-proportion-to-the-degree-of-cardiovascular-risk-and-related-to-inhibitory-control-deficits
#12
Pedro P Santos, Paula S Da Silveira, Fabio L Souza-Duran, Jaqueline H Tamashiro-Duran, Márcia Scazufca, Paulo R Menezes, Claudia Da Costa Leite, Paulo A Lotufo, Homero Vallada, Maurício Wajngarten, Tânia C De Toledo Ferraz Alves, Patricia Rzezak, Geraldo F Busatto
Cardiovascular risk (CVR) factors may be associated with poor cognitive functioning in elderlies and impairments in brain structure. Using MRI and voxel-based morphometry (VBM), we assessed regional white matter (WM) volumes in a population-based sample of individuals aged 65-75 years (n = 156), subdivided in three CVR subgroups using the Framingham Risk Score. Cognition was assessed using the Short Cognitive Performance Test. In high-risk subjects, we detected significantly reduced WM volume in the right juxtacortical dorsolateral prefrontal region compared to both low and intermediate CVR subgroups...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28183786/extracellular-rnas-are-associated-with-insulin-resistance-and-metabolic-phenotypes
#13
Ravi Shah, Venkatesh Murthy, Michael Pacold, Kirsty Danielson, Kahraman Tanriverdi, Martin G Larson, Kristina Hanspers, Alexander Pico, Eric Mick, Jared Reis, Sarah de Ferranti, Elizaveta Freinkman, Daniel Levy, Udo Hoffmann, Stavroula Osganian, Saumya Das, Jane E Freedman
OBJECTIVE: Insulin resistance (IR) is a hallmark of obesity and metabolic disease. Circulating extracellular RNAs (ex-RNAs), stable RNA molecules in plasma, may play a role in IR, though most studies on ex-RNAs in IR are small. We sought to characterize the relationship between ex-RNAs and metabolic phenotypes in a large community-based human cohort. RESEARCH DESIGN AND METHODS: We measured circulating plasma ex-RNAs in 2,317 participants without diabetes in the Framingham Heart Study (FHS) Offspring Cohort at cycle 8 and defined associations between ex-RNAs and IR (measured by circulating insulin level)...
February 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28179224/dietary-protein-is-associated-with-musculoskeletal-health-independently-of-dietary-pattern-the-framingham-third-generation-study
#14
Kelsey M Mangano, Shivani Sahni, Douglas P Kiel, Katherine L Tucker, Alyssa B Dufour, Marian T Hannan
Background: Above-average dietary protein, as a single nutrient, improves musculoskeletal health. Evaluating the link between dietary protein and musculoskeletal health from a whole-diet perspective is important, as dietary guidelines focus on dietary patterns.Objective: We examined the prospective association of novel dietary protein food clusters (derived from established dietary pattern techniques) with appendicular lean mass (ALM), quadriceps strength (QS), and bone mineral density (BMD) in 2986 men and women, aged 19-72 y, from the Framingham Third Generation Study...
February 8, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28178938/messenger-rna-and-microrna-transcriptomic-signatures-of-cardiometabolic-risk-factors
#15
David D McManus, Jian Rong, Tianxiao Huan, Sean Lacey, Kahraman Tanriverdi, Peter J Munson, Martin G Larson, Roby Joehanes, Venkatesh Murthy, Ravi Shah, Jane E Freedman, Daniel Levy
BACKGROUND: Cardiometabolic (CM) risk factors are heritable and cluster in individuals. We hypothesized that CM risk factors are associated with multiple shared and unique mRNA and microRNA (miRNA) signatures. We examined associations of mRNA and miRNA levels with 6 CM traits: body mass index, HDL-cholesterol and triglycerides, fasting glucose, and systolic and diastolic blood pressures through cross-sectional analysis of 2812 Framingham Heart Study who had whole blood collection for RNA isolation for mRNA and miRNA expression studies and who consented to genetic research...
February 8, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28178209/effects-of-a-combination-of-berberis-aristata-silybum-marianum-and-monacolin-on-lipid-profile-in-subjects-at-low-cardiovascular-risk-a-double-blind-randomized-placebo-controlled-trial
#16
Derosa Giuseppe, D'Angelo Angela, Romano Davide, Maffioli Pamela
The aim of this study was to evaluate the efficacy and safety of an anti-hypercholesterolemic agent containing Berberis aristata, Silybum marianum and monacolin K and KA in a sample of Caucasian patients at low cardiovascular risk according to Framingham score. The primary outcome was to evaluate the effects of this nutraceutical combination on lipid profile; the secondary outcome was to evaluate the effect on some inflammatory markers, in particular high sensitivity C-reactive protein and tumor necrosis factor-α interleukin-6...
February 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28168796/plasma-biomarker-levels-and-non-obstructive-coronary-artery-disease-determined-by-coronary-computed-tomography-angiography
#17
Elin B Brolin, Stefan Agewall, Kerstin Cederlund, Christina Ekenbäck, Loghman Henareh, Karin Malmqvist, Andreas Rück, Anders Svensson, Per Tornvall
PURPOSE: Coronary computed tomography angiography (CTA) and several circulating biomarkers have prognostic value regarding cardiovascular disease (CVD) events, but their association is incompletely studied. We aimed to investigate whether markers of lipid metabolism, inflammation and kidney function could predict non-obstructive coronary artery disease (CAD) determined by coronary CTA, in a low-to-intermediate-risk group. METHODS: Coronary CTA and laboratory testing were performed for 115 subjects (45-70 years), with low prevalence of CVD risk factors, predominantly low-to-intermediate Framingham risk and normal or mildly reduced kidney function...
February 6, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28164772/clinical-and-environmental-correlates-of-serum-bdnf-a-descriptive-study-with-plausible-implications-for-ad-research
#18
Galit Weinstein, Sarah R Preis, Alexa S Beiser, Bernhard Kaess, Tai C Chen, Claudia Satizabal, Faisal Rahman, Emelia J Benjamin, Vasan S Ramachandran, Sudha Seshadri
BACKGROUND: Brain derived neurotrophic factor (BDNF) may play a central role in the pathogenesis of Alzheimer's disease (AD) through neurotrophic effects on basal cholinergic neurons. Reduced serum levels of BDND are observed among AD patients and may predict AD risk. Nevertheless, knowledge about factors associated with its levels in blood is lacking. OBJECTIVE: To identify clinical and demographic correlated of serum BDNF levels . METHODS: BDNF was measured from serum collected between 1992-1996 and 1998-2001 in participants from the Original and Offspring cohorts of the Framingham Study, respectively...
February 2, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28162137/are-parkinson-s-patients-more-vulnerable-to-the-effects-of-cardiovascular-risk-a-neuroimaging-and-neuropsychological-study
#19
Jacob D Jones, Jared J Tanner, Michael Okun, Catherine C Price, Dawn Bowers
OBJECTIVES: This study examined whether individuals with Parkinson's disease (PD) are at increased vulnerability for vascular-related cognitive impairment relative to controls. The underlying assumption behind this hypothesis relates to brain reserve and that both PD and vascular risk factors impair similar fronto-executive cognitive systems. METHODS: The sample included 67 PD patients and 61 older controls (total N=128). Participants completed neuropsychological measures of executive functioning, processing speed, verbal delayed recall/memory, language, and auditory attention...
February 6, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28159800/a-revised-framingham-stroke-risk-profile-to-reflect-temporal-trends
#20
Carole Dufouil, Alexa S Beiser, Leslie A McClure, Philip A Wolf, Christophe Tzourio, Virginia J Howard, Andrew J Westwood, Jayandra J Himali, Lisa M Sullivan, Hugo J Aparicio, Margaret Kelly-Hayes, Karen Ritchie, Carlos S Kase, Aleksandra Pikula, Jose R Romero, Ralph B D'Agostino, Cécilia Samieri, Ramachandran S Vasan, Genevieve Chêne, George Howard, Sudha Seshadri
BACKGROUND: -Age-adjusted stroke incidence has decreased over the past 50 years, likely due to changes in the prevalence and impact of various stroke risk factors. An updated version of the Framingham Stroke Risk Profile (FSRP) might better predict current risks in the Framingham Heart Study (FHS) and other cohorts. We compared the accuracy of the standard (Old), and of a revised (New) version of the FSRP in predicting the risk of all-stroke and ischemic stroke, and validated this new FSRP in two external cohorts, the 3 Cities (3C) and REGARDS studies...
February 3, 2017: Circulation
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