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https://www.readbyqxmd.com/read/29241303/body-fluid-status-assessment-by-bio-impedance-analysis-in-patients-presenting-to-the-emergency-department-with-dyspnea
#1
Chan Soon Park, Sang-Eun Lee, Hyun-Jai Cho, Yong-Jin Kim, Hyun-Jae Kang, Byung-Hee Oh, Hae-Young Lee
Background/Aims: Fluid retention occurs in patients with heart failure, accounting for dyspnea. We investigated the diagnostic implication of body fluid status, assessed by bio-impedance analysis (BIA), in acute heart failure (AHF) among patients who presented with dyspnea. Methods: A total of 100 patients who presented with dyspnea and suspected with AHF were analyzed in this study. We enrolled 50 AHF and 50 non-AHF patients discriminated through echocardiographic analysis and Framingham criteria and were matched by age and sex...
December 18, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29234678/follow-up-measurement-of-corrected-qt-interval-in-adult-patients-before-and-after-lung-transplantation
#2
Dirk Bandorski, Reinhard Hoeltgen, Nicole Becker, Winfried Padberg, Harilaos Bogossian, Christoph Wiedenroth, Matthias Arlt, Christian Hamm, Werner Seeger, Hossein Ardeschir Ghofrani, Matthias Hecker, Henning Gall, Konstantin Mayer
Background: Prolongation of the corrected QT (QTc) interval is well known for many drugs, some of which are an integral part of the therapeutic regimen after lung transplantation (LTX). Therefore, we investigated the QTc interval after LTX in the present study. Patients and Methods: The medical records of patients after LTX were studied for demographic data, indication of LTX, medication, and baseline and follow-up ECGs. The QT interval was corrected for the patient's heart rate using the different formulae of Bazett, Fridericia, Hodges, and Framingham...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29226174/proprotein-convertase-subtilisin-kexin-9-levels-in-relation-to-systemic-immune-activation-and-subclinical-coronary-plaque-in-hiv
#3
Markella V Zanni, Lauren A Stone, Mabel Toribio, Dodie E Rimmelin, Jake Robinson, Tricia H Burdo, Kenneth Williams, Kathleen V Fitch, Janet Lo, Steven K Grinspoon
Background: Proprotein convertase subtilisin/kexin 9 (PCSK9) is known to mediate homeostasis of low-density lipoprotein cholesterol (LDL-c), but it may also participate in immune reactivity and atherogenesis. Methods: We compared circulating PCSK9 levels among asymptomatic individuals with and without HIV. Further, within each group, we assessed the relationship between PCSK9 levels, traditional cardiovascular disease risk factors, immune activation, and subclinical coronary atherosclerotic plaque...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29224996/cost-effectiveness-of-the-non-laboratory-based-framingham-algorithm-in-primary-prevention-of-cardiovascular-disease-a-simulated-analysis-of-a-cohort-of-african-american-adults
#4
Jacob K Kariuki, Philimon Gona, Suzanne G Leveille, Eileen M Stuart-Shor, Laura L Hayman, Jerry Cromwell
The non-lab Framingham algorithm, which substitute body mass index for lipids in the laboratory based (lab-based) Framingham algorithm, has been validated among African Americans (AAs). However, its cost-effectiveness and economic tradeoffs have not been evaluated. This study examines the incremental cost-effectiveness ratio (ICER) of two cardiovascular disease (CVD) prevention programs guided by the non-lab versus lab-based Framingham algorithm. We simulated the World Health Organization CVD prevention guidelines on a cohort of 2690 AA participants in the Atherosclerosis Risk in Communities (ARIC) cohort...
December 7, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29222122/increased-aortic-diameters-on-multidetector-computed-tomographic-scan-are-independent-predictors-of-incident-adverse-cardiovascular-events-the-framingham-heart-study
#5
Saadia Qazi, Joseph M Massaro, Michael L Chuang, Ralph B D'Agostino, Udo Hoffmann, Christopher J O'Donnell
BACKGROUND: Adverse aortic remodeling, such as dilation, is associated with multiple cardiovascular disease (CVD) risk factors. We sought to determine whether measures of enlarged aortic diameters improve prediction of incident adverse CVD events above standard CVD risk factors in a community-dwelling cohort. METHODS AND RESULTS: Participants from the Framingham Offspring and Third Generation Cohorts (n=3318; aged 48.9±10.3 years), who underwent noncontrast thoracic and abdominal multidetector computed tomography during 2002 to 2005, had complete risk factor profiles, and were free of clinical CVD, were included in this study...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29218908/analyzing-metabolomics-data-for-association-with-genotypes-using-two-component-gaussian-mixture-distributions
#6
Jason Westra, Nicholas Hartman, Bethany Lake, Gregory Shearer, Nathan Tintle
Standard approaches to evaluate the impact of single nucleotide polymorphisms (SNP) on quantitative phenotypes use linear models. However, these normal-based approaches may not optimally model phenotypes which are better represented by Gaussian mixture distributions (e.g., some metabolomics data). We develop a likelihood ratio test on the mixing proportions of two-component Gaussian mixture distributions and consider more restrictive models to increase power in light of a priori biological knowledge. Data were simulated to validate the improved power of the likelihood ratio test and the restricted likelihood ratio test over a linear model and a log transformed linear model...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29216249/longer-time-to-peak-glucose-during-the-oral-glucose-tolerance-test-increases-cardiovascular-risk-score-and-diabetes-prevalence
#7
Yi-Chun Lin, Harn-Shen Chen
INTRODUCTION: The pattern of glucose levels during an oral glucose tolerance test (OGTT) may be useful for predicting diabetes or cardiovascular disease (CVD). Our aim was to determine whether the time to peak glucose during the OGTT is associated with CVD risk scores and diabetes. METHODS: Individuals with impaired fasting glucose (IFG) were enrolled in this observational study. Participants were grouped by the measured time to peak glucose (30, 60, 90 and 120 min) during the 75g OGTT...
2017: PloS One
https://www.readbyqxmd.com/read/29214035/cardiovascular-risk-profiles-in-a-lupus-cohort-what-do-different-calculators-tell-us
#8
Daniel Boulos, Rachel L Koelmeyer, Eric F Morand, Alberta Y Hoi
Background: Cardiovascular disease (CVD) is the leading cause of death worldwide and this risk is increased in patients with SLE who may not conform to traditional cardiovascular risk profiles. Aims: To determine the prevalence of high CVD risk among patients with SLE calculated using different risk calculators, and to characterise those identified as high risk. Methods: A cross-sectional analysis to estimate CVD risk using the Framingham Risk Equation (Framingham score) and an SLE-specific CVD risk equation (SLE score) was undertaken using data from a single centre cohort...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29209360/assortative-mating-by-ethnicity-in-longevous-families
#9
Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Stacy L Andersen, Thomas T Perls
Recent work shows strong evidence of ancestry-based assortative mating in spouse pairs of the older generation of the Framingham Heart Study. Here, we extend this analysis to two studies of human longevity: the Long Life Family Study (LLFS), and the New England Centenarian Study (NECS). In the LLFS, we identified 890 spouse pairs spanning two generations, while in the NECS we used data from 102 spouse pairs including offspring of centenarians. We used principal components of genome-wide genotype data to demonstrate strong evidence of ancestry-based assortative mating in spouse pairs of the older generation and also confirm the decreasing trend of endogamy in more recent generations...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29207753/a-study-of-correlation-of-neck-circumference-with-framingham-risk-score-as-a-predictor-of-coronary-artery-disease
#10
Anand K Koppad, Ram S Kaulgud, B S Arun
Introduction: It has been observed that metabolic syndrome is risk factor for Coronary Artery Disease (CAD) and exerts its effects through fat deposition and vascular aging. CAD has been acknowledged as a leading cause of death. In earlier studies, the metabolic risk has been estimated by Framingham risk score. Recent studies have shown that Neck Circumference (NC) has a good correlation with other traditional anthropometric measurements and can be used as marker of obesity. It also correlates with Framingham risk score, which is slightly more sophisticated measure of CAD risk...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206805/axial-to-centrifugal-continuous-flow-lvad-pump-exchange-using-minimally-invasive-technique
#11
Amit A Pawale, Ariel Farkash, Dimosthenis Pandis, Anelechi C Anyanwu
Driveline or device infection may complicate left ventricular assist device implants, and only curative option may be pump exchange. Replacement with similar device may be liable to reinfection, because pump configuration is such that the new device and driveline may partly lie within the pocket of the previous pump. One approach to overcome this is using a different pump design such that the new pump would lie in a different location from the old pump. We describe treatment of severe HeartMate II (Abbott, [St Jude Thoratec Corp], Pleasanton, CA USA) left ventricular assist device infection by minimally invasive exchange to an intrapericardial HVAD (HeartWare International, Inc, Framingham, MA USA) left ventricular assist device...
November 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29200560/a-cross-sectional-study-to-estimate-cardiovascular-risk-factors-in-patients-with-bipolar-disorder
#12
Swetha Reddy Damegunta, Prasad Rao Gundugurti
Background: There is increasing recognition of cardiovascular mortality and comorbidity in bipolar disorder (BD) in the recent times. Framingham 10 years risk of coronary heart disease (CHD) has been a widely accepted as a reliable estimate of cardiovascular risk in the general population. A few studies have estimated the relative risk of developing CHD in BDs, in India. We attempt to present a cross-sectional data from a prospective study to estimate the 10 years cardiovascular risk in BD population...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29198934/novel-polymorphisms-associated-with-hyperalphalipoproteinemia-and-apparent-cardioprotection
#13
Connor P Oates, Darya Koenig, Jeffrey Rhyne, Nikolay Bogush, Jeffrey O'Connell, Braxton D Mitchell, Michael Miller
BACKGROUND: Hyperalphalipoproteinemia (HALP) is inversely correlated with coronary heart disease (CHD) although genetic variants associated with high serum levels of high-density lipoprotein cholesterol (HDL-C) have not been shown to be cardioprotective. OBJECTIVE: The objective of the study was to uncover novel genetic variants associated with HALP and possibly with reduced risk of CHD. METHODS: Exome sequencing data, HDL-C, and triglyceride levels were analyzed in 1645 subjects...
November 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29198741/pregnancy-as-an-early-stress-test-for-cardiovascular-and-kidney-disease-diagnosis
#14
Thaís Alquezar Facca, Gianna Mastroianni-Kirsztajn, Amélia Rodrigues Pereira Sabino, Michelle Tiveron Passos, Larissa Fátima Dos Santos, Eduardo Augusto Brosco Famá, Sonia Kiyomi Nishida, Nelson Sass
OBJECTIVES: Pregnancy is a cardiometabolic and renal stress test for women, primarily when associated with hypertension syndrome, which can have deleterious effects in the long term. We undertook this study to make a long-term evaluation on these women. STUDY DESIGN: A retrospective cohort study was conducted to investigate voluntary women who had pregnancy-induced hypertension syndrome versus normal pregnancy. MAIN OUTCOME MEASURES: We evaluated a total of 85 women, divided in case (n = 25) and control (n = 60) groups, by clinical, anthropometric and epidemiological profiles, general, metabolic and renal tests, and risk stratification for cardiovascular disease (CVD) and chronic kidney disease (CKD)...
November 23, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29197965/progress-of-statistical-analysis-in-biomedical-research-through-the-historical-review-of-the-development-of-the-framingham-score
#15
Aleksandra Ignjatović, Miodrag Stojanović, Zoran Milošević, Marija Anđelković Apostolović
BACKGROUND: The interest in developing risk models in medicine not only is appealing, but also associated with many obstacles in different aspects of predictive model development. Initially, the association of biomarkers or the association of more markers with the specific outcome was proven by statistical significance, but novel and demanding questions required the development of new and more complex statistical techniques. METHODS: Progress of statistical analysis in biomedical research can be observed the best through the history of the Framingham study and development of the Framingham score...
December 2, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29197532/vascular-risk-factor-burden-and-new-onset-depression-in-the-community
#16
Shayna Adams, Sarah Conner, Jayandra J Himali, Alexa Beiser, Ramachandran S Vasan, Sudha Seshadri, Matthew P Pase
Depression is associated with an increased likelihood of cardiac events and stroke. We hypothesized that the vascular risk factor burden might itself predispose to both cardiovascular events and depression. Therefore, we examined whether aggregate scores of vascular risk factor burden were associated with the new-onset of depression in the community. We studied 2023 depression- and dementia-free Framingham Heart Study (Framingham, USA) Offspring participants who attended both examination cycles 7 (1998-2001) and 8 (2005-2008)...
November 29, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29195110/brachial-artery-diameter-as-a-marker-for-cardiovascular-risk-assessment-fmd-j-study
#17
Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Hisao Ikeda, Akira Yamashina, Yukihito Higashi
BACKGROUND AND AIMS: Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in subjects without cardiovascular risk factors and patients with cardiovascular disease (CVD) with that of FMD. METHODS: We measured BBA diameter and FMD in 5695 male subjects...
November 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29193936/-evaluation-of-cardiovascular-risk-factors-in-obesity-before-and-after-bariatric-surgery
#18
Karla Leticia Sánchez-Ruiz, Aldo Ferreira-Hermosillo, Mario Antonio Molina-Ayala, Claudia Ramírez-Rentería, Victoria Mendoza-Zubieta
BACKGROUND: Mexico has one of the highest prevalences of severe obesity worldwide. Mortality in those patients may be as high as 90% mainly due to cardiovascular disease. Despite Framingham score has been validated in the Mexican population, it only predicts cardiovascular risk at 10 years. Meanwhile ASCVD10 score could evaluate risk at 10 years and through lifetime. None of these scores have been used for cardiovascular risk assessment in Mexican patients with severe obesity. METHODS: We conducted a quasi-experimental (before/ after) study with 109 patients with severe obesity, assessed prevalence of comorbidities, performed anthropometric and biochemical evaluations before and a year after bariatric surgery...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29193523/barriers-to-medication-adherence-and-links-to-cardiovascular-disease-risk-factor-control-the-framingham-heart-study
#19
Rachel Hennein, Shih-Jen Hwang, Rhoda Au, Daniel Levy, Paul Muntner, Caroline S Fox, Jiantao Ma
BACKGROUND: In the elderly, impaired cognition may weaken medication adherence and compromise treatment for cardiovascular disease (CVD). AIMS: We examined risk factors for medication adherence and the relationship between adherence and levels of CVD risk factors among older participants with hypertension, dyslipidemia, and diabetes in the Framingham Heart Study. METHODS: The four-item Morisky Medication Adherence Scale was administered to 1,559 participants, median age 70 years, 53% women...
November 30, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29192146/cardiovascular-disease-risk-assessment-in-the-united-states-and-low-and-middle-income-countries-using-predicted-heart-vascular-age
#20
Duke Appiah, Benjamin D Capistrant
Almost 80% of the global burden of cardiovascular disease (CVD) occurs in low- and middle-income countries (LMICs). However, LMICs do not have well-established, low-technology ways to quantify and communicate CVD risk at population or individual levels. We examined predicted heart/vascular age (PHA) in six LMICs and the United States. Data were from CVD-free adults in World Health Organization Study on Global Aging and Adult Health (n = 29094) and US National Health and Nutritional Examination Survey (n = 6726)...
November 30, 2017: Scientific Reports
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