keyword
MENU ▼
Read by QxMD icon Read
search

house call

keyword
https://www.readbyqxmd.com/read/29137867/functionalized-2-1-benzothiazine-2-2-dioxides-as-new-inhibitors-of-dengue-ns5-rna-dependent-rna-polymerase
#1
Rolando Cannalire, Delia Tarantino, Andrea Astolfi, Maria Letizia Barreca, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Mario Milani, Gilles Querat, Eloise Mastrangelo, Giuseppe Manfroni, Violetta Cecchetti
Over recent years, many RNA viruses have been "re-discovered", including life-threatening flaviviruses, such as Dengue, Zika, and several encephalitis viruses. Since no specific inhibitors are currently available to treat these infections, there is a pressing need for new therapeutics. Among the flaviviral proteins, NS5 RNA-dependent RNA polymerase (RdRp) represents a validated target being essential for viral replication and it has no human analog. To date, few NS5 RdRp inhibitor chemotypes have been reported and no inhibitors are currently in clinical development...
November 11, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29126106/airvf-a-filtering-toolbox-for-precise-variant-calling-in-ion-torrent-sequencing
#2
Sunguk Shin, Hanna Lee, Hyeonju Son, Soonmyung Paik, Sangwoo Kim
Summary: Ion Torrent sequencing is one of the most frequently used platforms in healthcare research and industry. Despite many advantages, platform-specific artifacts complicate efficient separation of true variants from errors, especially in variants with lower allele frequencies (<15%). Here, we developed a multi-step filtering toolbox AIRVF that works on flowgram, raw and mapped reads and called variants to reduce artifact-driven false variant calls. Tests on sequencing data of standard reference material showed up to ∼98% reduction of false variants when combined to conventional public pipelines and ∼48% to the in-house commercial solution, with a minimal loss of sensitivity...
November 6, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29120202/collaboration-confidentiality-and-care
#3
Latoya S Moss
There is an increasing call to attend to the needs of students in distress (Reynolds, 2013). Furthermore, research has begun to highlight links between distress, risky, or dangerous behaviors as well as issues in mental health in the higher education population (Deasy, Coughlan, Pironom, Jourdan, & Mannix-McNamara, 2014). The National Alliance on Mental Health and the Jed Foundation (National Alliance on Mental Illness & the Jed Foundation, 2016) estimate that about 20% of enrolled college students will face some type of mental illness...
November 2017: Psychological Services
https://www.readbyqxmd.com/read/29114864/the-multidimensional-politics-of-inequality-taking-stock-of-identity-politics-in-the-u-s-presidential-election-of-2016
#4
Leslie McCall, Ann Shola Orloff
Many Democrats hoped that a particular kind of identity politics - women's - would help Hillary Clinton win the White House. In the aftermath of the election, some commentators bemoaned the fact that a majority of white women had voted for Trump, and called it a kind of betrayal, underlining their expectation that women would naturally, on the basis of their gender identity, support a woman with women-friendly politics. Indeed, this kind of thinking about identity politics has been widespread with reference to a number of demographic groups...
November 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/29111876/impact-of-anticipated-bias-from-healthcare-professionals-on-perceived-successful-aging-among-transgender-and-gender-nonconforming-older-adults
#5
Ruth V Walker, Sara M Powers, Tarynn M Witten
PURPOSE: Transgender and gender nonconforming (TGNC) persons have routinely experienced high rates of violence and discrimination. Discrimination in healthcare can affect the ability of TGNC persons to age successfully as it often deters them from seeking care. The purpose of this study was to determine if anticipation of bias from healthcare professionals, as well as other variables, predicted perceived successful aging in a sample of TGNC adults. METHODS: A total of 384 (of the original 1963) participants older than 50 years completed the relevant parts of an 83-item online survey as part of the Trans MetLife Survey on Later-Life Preparedness and Perceptions in Transgender-Identified Individuals...
November 7, 2017: LGBT Health
https://www.readbyqxmd.com/read/29101246/evaluation-of-the-mycoplasma-genitalium-resistance-plus-kit-for-the-detection-of-m-genitalium-and-mutations-associated-with-macrolide-resistance
#6
Rachel Pitt, Michelle Jayne Cole, Helen Fifer, Neil Woodford
OBJECTIVES: To compare performance of the ResistancePlus kit (SpeeDx, Australia) with in-house methods for the detection of Mycoplasma genitalium-specific DNA and mutations associated with resistance to macrolide antimicrobials, directly from clinical specimens. METHODS: Assay specificity and sensitivity was analysed using DNA from 46 non-M. genitalium organisms and standard curve analysis, respectively. A panel of archived DNA extracted from 97 M. genitalium-positive clinical specimens, for which the macrolide susceptibility genotype had been previously determined, were tested on the assay and results compared...
November 3, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29093825/an-outbreak-of-leptospirosis-among-united-states-military-personnel-in-guam
#7
Alyson J Brinker, David L Blazes
Background: Leptospirosis is a bacterial zoonotic disease with worldwide distribution. Case presentation: We describe and discuss the clinical course of a leptospirosis outbreak in a running club called the hash house harriers on Guam. Conclusions: Leptospirosis is a potentialy life threatening disease, and has had a reemergence given the popularity of travel adventure sports, teams, and clubs around the world. This case presentation highlights the robust prescence of leptospirosis on Guam...
2017: Tropical Diseases, Travel Medicine and Vaccines
https://www.readbyqxmd.com/read/29082488/guidelines-for-microplate-selection-in-high-content-imaging
#8
Oscar J Trask
Since the inception of commercialized automated high content screening (HCS) imaging devices in the mid to late 1990s, the adoption of media vessels typically used to house and contain biological specimens for interrogation has transitioned from microscope slides and petri dishes into multi-well microtiter plates called microplates. The early 96- and 384-well microplates commonly used in other high-throughput screening (HTS) technology applications were often not designed for optical imaging. Since then, modifications and the use of next-generation materials with improved optical clarity have enhanced the quality of captured images, reduced autofocusing failures, and empowered the use of higher power magnification objectives to resolve fine detailed measurements at the subcellular pixel level...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29080372/promiscuity-punishes-sexual-deviants
#9
Leif Engqvist, Steven A Ramm
Sex is good for us, but it is a compromise. For the benefit of being able to produce genetically variable offspring, we must pay the cost of passing on only half our genes to each of them. Whilst evolutionary biologists still puzzle over the precise details of why the benefits of sex so frequently seem to outweigh the costs (Neiman, Lively, & Meirmans, ), one major challenge to sexual reproduction is the fact that if we pass on only half our genetic material to each gamete, there is a strong incentive for each individual allele to try to gain an unfair representation during gamete production...
October 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29077968/problem-behaviors-in-adult-laying-hens-identifying-risk-factors-during-rearing-and-egg-production
#10
Margrethe Brantsæter, Janicke Nordgreen, Tone B Hansen, Karianne Muri, Ane Nødtvedt, Randi O Moe, Andrew M Janczak
Feather pecking, toe pecking, cannibalism, smothering, social clumping, hens laying eggs outside the nest boxes, and reduced feather quality are examples of problem behaviors and consequences reported by egg producers. The aim of this study was to identify rearing- and production-related risk factors associated with producer-reported problem behaviors in Norwegian layer flocks. Questionnaires were distributed to 410 egg producers nationwide, and 120 producers responded to the survey (response rate 29%). After exclusion of data that did not comply with the instructions, the final dataset included 78 flocks (19%)...
October 25, 2017: Poultry Science
https://www.readbyqxmd.com/read/29073219/environmental-enrichment-accelerates-ocular-dominance-plasticity-in-mouse-visual-cortex-whereas-transfer-to-standard-cages-resulted-in-a-rapid-loss-of-increased-plasticity
#11
Evgenia Kalogeraki, Justyna Pielecka-Fortuna, Siegrid Löwel
In standard cage (SC) raised mice, experience-dependent ocular dominance (OD) plasticity in the primary visual cortex (V1) rapidly declines with age: in postnatal day 25-35 (critical period) mice, 4 days of monocular deprivation (MD) are sufficient to induce OD-shifts towards the open eye; thereafter, 7 days of MD are needed. Beyond postnatal day 110, even 14 days of MD failed to induce OD-plasticity in mouse V1. In contrast, mice raised in a so-called "enriched environment" (EE), exhibit lifelong OD-plasticity...
2017: PloS One
https://www.readbyqxmd.com/read/29066957/effects-of-a-5-ht1b-receptor-agonist-on-locomotion-and-reinstatement-of-cocaine-conditioned-place-preference-after-abstinence-from-repeated-injections-in-mice
#12
Taleen S Der-Ghazarian, Tanessa Call, Samantha N Scott, Kael Dai, Samuel J Brunwasser, Sean N Noudali, Nathan S Pentkowski, Janet L Neisewander
5-HT1B receptors (5-HT1BRs) modulate behavioral effects of cocaine. Here we examined the effects of the 5-HT1BR agonist 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine (CP94253) on spontaneous and cocaine-induced locomotion and on cocaine-primed reinstatement of conditioned place preference (CPP) in male mice given daily repeated injections of either saline or cocaine (15 mg/kg, IP) for 20 days. In the locomotor activity experiment, testing occurred both 1 and 20 days after the final injection...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29065005/finding-mary-at-home-learning-through-house-calls
#13
Shefali Hegde
No abstract text is available yet for this article.
November 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29061127/the-underlying-reasons-for-very-high-levels-of-bed-net-use-and-higher-malaria-infection-prevalence-among-bed-net-users-than-non-users-in-the-tanzanian-city-of-dar-es-salaam-a-qualitative-study
#14
Daniel Msellemu, Aloysia Shemdoe, Christina Makungu, Yeromini Mlacha, Khadija Kannady, Stefan Dongus, Gerry F Killeen, Angel Dillip
BACKGROUND: Bed nets reduce malaria-related illness and deaths, by forming a protective barrier around people sleeping under them. When impregnated with long-lasting insecticide formulations they also repel or kill mosquitoes attempting to feed upon sleeping humans, and can even suppress entire populations of malaria vectors that feed predominantly upon humans. Nevertheless, an epidemiological study in 2012 demonstrated higher malaria prevalence among bed net users than non-users in urban Dar es Salaam, Tanzania...
October 23, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29059981/towards-precise-tracking-of-electric-mechanical-cardiac-time-intervals-through-joint-ecg-and-bcg-sensing-and-signal-processing
#15
Haihong Zhang, Zimin Wang, Kejun Dong, Soon Huat Ng, Zhiping Lin
Automatic tracking of intra-beat cardiac activities in ballistocardiogram (BCG) is a highly interesting yet technically challenging topic for cardiac monitoring, due to the signal's high susceptibility to various forms of distortions. In this paper, we aim to further investigate the BCG waveform detection from a signal processing and analysis viewpoint. We collect synchronized electrocardiography(ECG) and BCG recordings from four healthy human subjects using an in-house built multi-physiological monitoring device...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29047335/candidate-lethal-haplotypes-and-causal-mutations-in-angus-cattle
#16
Jesse L Hoff, Jared E Decker, Robert D Schnabel, Jeremy F Taylor
BACKGROUND: If unmanaged, high rates of inbreeding in livestock populations adversely impact their reproductive fitness. In beef cattle, historical selection strategies have increased the frequency of several segregating fatal autosomal recessive polymorphisms. Selective breeding has also decreased the extent of haplotypic diversity genome-wide. By identifying haplotypes for which homozygotes are not observed but would be expected based on their frequency, candidates for developmentally lethal recessive loci can be localized...
October 18, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29040841/-caught-with-a-body-yet-protected-by-law-calling-911-for-opioid-overdose-in-the-context-of-the-good-samaritan-law
#17
Amanda D Latimore, Rachel S Bergstein
BACKGROUND: To address soaring opioid overdose fatality rates, 41U.S. states have passed Good Samaritan Laws (GSLs) extending legal immunity to overdose bystanders who call for emergency assistance. This study, conducted during the period that followed implementation of a GSL, aimed to characterize current factors determining the decision to call for emergency medical help (911) at the scene of an overdose with specific attention to exploring the role of the GSL as one such factor in decision-making...
October 14, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29037970/early-years-postgraduate-surgical-training-programmes-in-the-uk-are-failing-to-meet-national-quality-standards-an-analysis-from-the-asit-bota-lost-tribe-prospective-cohort-study-of-2-569-surgical-trainees
#18
(no author information available yet)
INTRODUCTION: This study aimed to assess training of Senior House Officer-grade equivalent doctors in postgraduate surgical training or service (SHO-DIPST) in surgical specialties across the United Kingdom (UK), against nationally agreed Joint Committee on Surgical Training Quality Indicators (JCST QIs). Specific recommendations are made, with a view to improving quality of training, workforce retention and recruitment to Higher Surgical Training. METHOD: Prospective, observational, multicentre study conducted by the Association of Surgeons in Training, using the UK National Research Collaborative model...
October 13, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28992262/a-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-reference-database-for-the-identification-of-histoplasma-capsulatum
#19
Clara Valero, María J Buitrago, Sara Gago, Inmaculada Quiles-Melero, Julio García-Rodríguez
The isolation of the pathogenic fungus Histoplasma capsulatum from cultures together with the visualization of typical intracellular yeast in tissues are the gold standard methods for diagnosis of histoplasmosis. However, cultures are time-consuming, require level 3 containment and experienced personnel, and usually call for an additional confirmation test. Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-ToF MS) has been established as a suitable tool for microbial identification in several clinical laboratories...
July 28, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28992053/molecular-and-neuroendocrine-approaches-to-understanding-trade-offs-food-sex-aggression-stress-and-longevity-an-introduction-to-the-symposium
#20
Jill E Schneider, Pierre Deviche
Life history strategies are composed of multiple fitness components, each of which incurs costs and benefits. Consequently, organisms cannot maximize all fitness components simultaneously. This situation results in a dynamic array of trade-offs in which some fitness traits prevail at the expense of others, often depending on context. The identification of specific constraints and trade-offs has helped elucidate physiological mechanisms that underlie variation in behavioral and physiological life history strategies...
September 11, 2017: Integrative and Comparative Biology
keyword
keyword
67985
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"