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https://www.readbyqxmd.com/read/28421180/usability-evaluations-of-a-wearable-inertial-sensing-system-and-quality-of-movement-metrics-for-stroke-survivors-by-care-professionals
#1
Bart Klaassen, Bert-Jan F van Beijnum, Jeremia P Held, Jasper Reenalda, Fokke B van Meulen, Peter H Veltink, Hermie J Hermens
BACKGROUND: Inertial motion capture systems are used in many applications such as measuring the movement quality in stroke survivors. The absence of clinical effectiveness and usability evidence in these assistive technologies into rehabilitation has delayed the transition of research into clinical practice. Recently, a new inertial motion capture system was developed in a project, called INTERACTION, to objectively measure the quality of movement (QoM) in stroke survivors during daily-life activity...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28418835/costs-and-effectiveness-of-treating-homeless-persons-with-cocaine-addiction-with-alternative-contingency-management-strategies
#2
Stephen T Mennemeyer, Joseph E Schumacher, Jesse B Milby, Dennis Wallace
BACKGROUND: Between 1990 and 2006 in Birmingham, Alabama USA, 4 separate randomized controlled studies, called "Homeless 1" through "Homeless 4", treated cocaine substance abuse among chronically homeless adults, largely black men, many with non-psychotic mental health problems. The 4 studies had 9 treatment arms that used various counseling methods plus, in some arms, the provision of housing and work therapy usually with a contingent requirement of urine-test verified abstinence from substances...
March 1, 2017: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/28410391/cilia-and-sensory-signaling-the-journey-from-animalcules-to-human-disease
#3
Piali Sengupta
Nearly all cell types in mammals contain cilia, small rod-like or more elaborate structures that extend from the cell surface. Cilia house signaling proteins that allow the cell to sample their environment and respond appropriately. Mutations in ciliary genes alter the functions of a broad range of cell and tissue types, including sensory and central neurons, and underlie a collection of heterogeneous human disorders called ciliopathies. Here, I highlight the critical contributions of nearly three centuries of research in diverse organisms to our current knowledge of cilia function in sensory signaling and human disease...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28409485/cohesion-network-analysis-of-cscl-participation
#4
Mihai Dascalu, Danielle S McNamara, Stefan Trausan-Matu, Laura K Allen
The broad use of computer-supported collaborative-learning (CSCL) environments (e.g., instant messenger-chats, forums, blogs in online communities, and massive open online courses) calls for automated tools to support tutors in the time-consuming process of analyzing collaborative conversations. In this article, the authors propose and validate the cohesion network analysis (CNA) model, housed within the ReaderBench platform. CNA, grounded in theories of cohesion, dialogism, and polyphony, is similar to social network analysis (SNA), but it also considers text content and discourse structure and, uniquely, uses automated cohesion indices to generate the underlying discourse representation...
April 13, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28405385/cranial-arterial-patterns-of-the-alpaca-camelidae-vicugna-pacos
#5
Haley D O'Brien
Artiodactyl cranial arterial patterns deviate significantly from the standard mammalian pattern, most notably in the possession of a structure called the carotid rete (CR)-a subdural arterial meshwork that is housed within the cavernous venous sinus, replacing the internal carotid artery (ICA). This relationship between the CR and the cavernous sinus facilitates a suite of unique physiologies, including selective brain cooling. The CR has been studied in a number of artiodactyls; however, to my knowledge, only a single study to date documents a subset of the cranial arteries of New World camelids (llamas, alpacas, vicugñas and guanacoes)...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28404677/comparison-of-two-whole-genome-sequencing-methods-for-analysis-of-three-methicillin-resistant-staphylococcus-aureus-outbreaks
#6
Scott A Cunningham, Nicholas Chia, Patricio R Jeraldo, Daniel J Quest, Julie A Johnson, Dave J Boxrud, Angela J Taylor, Jun Chen, Gregory D Jenkins, Travis M Drucker, Heidi Nelson, Robin Patel
Whole genome sequencing (WGS) can provide excellent resolution in global and local epidemiological investigations of Staphylococcus aureus outbreaks. A variety of sequencing approaches and analytical tools have been used; it is not clear which is ideal. We compared two WGS strategies and two analytical approaches to the standard method of SmaI restriction digestion pulsed-field gel electrophoresis (PFGE) for typing S. aureus Forty-two S. aureus isolates from three outbreaks and 12 reference isolates were studied...
April 12, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28395349/examining-the-usefulness-of-iso-10819-anti-vibration-glove-certification
#7
Diandra Budd, Ron House
Anti-vibration gloves are commonly worn to reduce hand-arm vibration exposure from work with hand-held vibrating tools when higher priority and more effective controls are unavailable. For gloves to be marketed as 'anti-vibration' they must meet the vibration transmissibility criteria described in the International Organization for Standardization (ISO) standard 10819 (2013). Several issues exist with respect to the methodology used for glove testing as well as the requirements for glove design and composition in ISO 10819 (2013)...
March 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28381413/photoreceptor-discs-form-through-peripherin-dependent-suppression-of-ciliary-ectosome-release
#8
Raquel Y Salinas, Jillian N Pearring, Jin-Dong Ding, William J Spencer, Ying Hao, Vadim Y Arshavsky
The primary cilium is a highly conserved organelle housing specialized molecules responsible for receiving and processing extracellular signals. A recently discovered property shared across many cilia is the ability to release small vesicles called ectosomes, which are used for exchanging protein and genetic material among cells. In this study, we report a novel role for ciliary ectosomes in building the elaborate photoreceptor outer segment filled with hundreds of tightly packed "disc" membranes. We demonstrate that the photoreceptor cilium has an innate ability to release massive amounts of ectosomes...
April 5, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28376839/a-hybrid-iii-stepped-wedge-cluster-randomized-trial-testing-an-implementation-strategy-to-facilitate-the-use-of-an-evidence-based-practice-in-va-homeless-primary-care-treatment-programs
#9
Molly M Simmons, Sonya Gabrielian, Thomas Byrne, Megan B McCullough, Jeffery L Smith, Thom J Taylor, Tom P O'Toole, Vincent Kane, Vera Yakovchenko, D Keith McInnes, David A Smelson
BACKGROUND: Homeless veterans often have multiple health care and psychosocial needs, including assistance with access to housing and health care, as well as support for ongoing treatment engagement. The Department of Veterans Affairs (VA) developed specialized Homeless Patient Alignment Care Teams (HPACT) with the goal of offering an integrated, "one-stop program" to address housing and health care needs of homeless veterans. However, while 70% of HPACT's veteran enrollees have co-occurring mental health and substance use disorders, HPACT does not have a uniform, embedded treatment protocol for this subpopulation...
April 4, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28372566/the-cross-cutting-contribution-of-the-end-of-neglected-tropical-diseases-to-the-sustainable-development-goals
#10
REVIEW
Mathieu Bangert, David H Molyneux, Steve W Lindsay, Christopher Fitzpatrick, Dirk Engels
The Sustainable Development Goals (SDGs) call for an integrated response, the kind that has defined Neglected Tropical Diseases (NTDs) efforts in the past decade.NTD interventions have the greatest relevance for SDG3, the health goal, where the focus on equity, and its commitment to reaching people in need of health services, wherever they may live and whatever their circumstances, is fundamentally aligned with the target of Universal Health Coverage. NTD interventions, however, also affect and are affected by many of the other development areas covered under the 2030 Agenda...
April 4, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28362643/simulation-of-a-novel-schedule-for-intensivist-staffing-to-improve-continuity-of-patient-care-and-reduce-physician-burnout
#11
Alon Geva, Christopher P Landrigan, Meredith G van der Velden, Adrienne G Randolph
OBJECTIVE: Despite widespread adoption of in-house call for ICU attendings, there is a paucity of research on optimal scheduling of intensivists to provide continuous on-site coverage. Overnight call duties have traditionally been added onto 7 days of continuous daytime clinical service. We designed an alternative ICU staffing model to increase continuity of attending physician care for patients while also decreasing interruptions to attendings' nonclinical weeks. DESIGN: Computer-based simulation of a 1-year schedule...
March 30, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28338428/a-surgical-device-to-study-the-efficacy-of-bioengineered-skin-substitutes-in-mice-wound-healing-models
#12
Marc G Jeschke, Ali-Reza Sadri, Cassandra Belo, Saeid Amini-Nik
Due to the poor regenerative capacity of adult mammalian skin, there is a need to develop effective skin substitutes for promoting skin regeneration after a severe wound. However, the complexity of skin biology has made it difficult to enable perfect regeneration of skin. Thus, animal models are being used to test potential skin substitutes. Murine models are valuable but their healing process involves dermal contraction. We have developed a device called a dome that is able to eliminate the contraction effect of rodent skin while simultaneously housing a bioengineered skin graft...
April 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28317026/toxoplasma-gondii-ap2ix-4-regulates-gene-expression-during-bradyzoite-development
#13
Sherri Huang, Michael J Holmes, Joshua B Radke, Dong-Pyo Hong, Ting-Kai Liu, Michael W White, William J Sullivan
Toxoplasma gondii is a protozoan parasite of great importance to human and animal health. In the host, this obligate intracellular parasite persists as a tissue cyst that is imperceptible to the immune response and unaffected by current therapies. The tissue cysts facilitate transmission through predation and give rise to chronic cycles of toxoplasmosis in immunocompromised patients. Transcriptional changes accompany conversion of the rapidly replicating tachyzoites into the encysted bradyzoites, and yet the mechanisms underlying these alterations in gene expression are not well defined...
March 2017: MSphere
https://www.readbyqxmd.com/read/28281999/the-hidden-story-of-innovation-charity-hospital-angola-prison-and-the-challenging-of-surgical-dogma
#14
Patrick Greiffenstein, Paul R Hastings
The late 1960s was a period of significant upheaval of social, cultural, and scientific norms. The generally accepted notion of mandatory laparotomy for all penetrating abdominal injuries was among those norms being called into question across the country and many advocated expectant management of selected patients presenting with this type of injury. Leaders of the surgical community published opinions on either side of the argument. The house staff at Charity Hospital during this period was among the busiest in the nation in treating these injuries, many of them inmates of the Louisiana State Penitentiary who used self-inflicted stab wounds to the abdomen as a means of temporary respite from the inhumane conditions in the prison...
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28278745/-ballroom-itself-can-either-make-you-or-break-you-black-gbt-youths-psychosocial-development-in-the-house-ball-community
#15
Kyle Telander, Sybil G Hosek, Diana Lemos, Gihane Jeremie-Brink
Social context plays a significant role in adolescent identity development, particularly for youth lacking traditional systems of support. Using ecological and symbolic interactionism perspectives, this study qualitatively explored the psychosocial identity development of Black gay, bisexual, or transgendered youth participating in the House Ball Community (HBC). The HBC is a diverse network of family-like structures called 'houses', as well as a glamorous social outlet via pageant-like 'balls' in which participants compete...
March 3, 2017: Global Public Health
https://www.readbyqxmd.com/read/28274221/effectiveness-of-a-community-paramedic-led-health-assessment-and-education-initiative-in-a-seniors-residence-building-the-community-health-assessment-program-through-emergency-medical-services-chap-ems
#16
G Agarwal, R Angeles, M Pirrie, F Marzanek, B McLeod, J Parascandalo, L Dolovich
BACKGROUND: Seniors living in subsidized housing have lower income, poorer health, and increased risk for cardiometabolic diseases and falls. Seniors also account for more than one third of calls to Emergency Medical Services (EMS). This study examines the effectiveness of the Community Health Assessment Program through EMS (CHAP-EMS) in reducing blood pressure, diabetes risk, and EMS calls. METHODS: Paramedics on modified duty (e.g. injured) conducted weekly, one-on-one drop-in sessions in a common area of one subsidized senior's apartment building in Hamilton, Ontario...
March 9, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28244812/primary-care-providers-use-of-pharmacist-support-for-delivery-of-pharmacogenetic-testing
#17
Susanne B Haga, Rachel Mills, Jivan Moaddeb, Nancy Allen LaPointe, Alex Cho, Geoffrey S Ginsburg
AIM: To investigate provider utilization of pharmacist support in the delivery of pharmacogenetic testing in a primary care setting. METHODS: Two primary care clinics within Duke University Health System participated in the study between December 2012 and July 2013. One clinic was provided with an in-house pharmacist and the second clinic had an on-call pharmacist. RESULTS: Providers in the in-house pharmacist arm consulted with the pharmacist for 13 of 15 cases, or about one of every four patients tested compared with one of every 7...
March 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28228196/the-hidden-story-of-innovation-charity-hospital-angola-prison-and-the-challenging-of-surgical-dogma
#18
Patrick Greiffenstein, Paul R Hastings
The late 1960s was a period of significant upheaval of social, cultural, and scientific norms. The generally accepted notion of mandatory laparotomy for all penetrating abdominal injuries was among those norms being called into question across the country and many advocated expectant management of selected patients presenting with this type of injury. Leaders of the surgical community published opinions on either side of the argument. The house staff at Charity Hospital during this period was among the busiest in the nation in treating these injuries, many of them inmates of the Louisiana State Penitentiary who used self-inflicted stab wounds to the abdomen as a means of temporary respite from the inhumane conditions in the prison...
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28222838/prevalence-of-food-impaction-induced-periodontitis-in-conventionally-housed-marsh-rice-rats-oryzomys-palustris
#19
Jonathan G Messer, Jessica M Jiron, Hung-Yuan Chen, Evelyn J Castillo, Jorge L Mendieta Calle, Mary K Reinhard, Donald B Kimmel, J Ignacio Aguirre
Marsh rice rats (Oryzomys palustris) fed a pelleted diet high in sucrose and casein have been used as a model for moderate to severe periodontitis. Here we characterize the prevalence, location, and histopathologic features of food-impaction lesions (FIL), a unique type of oral event, in rice rats fed standard pelleted rodent chow from weaning until 34 wk of age. Healthy female rats (n = 90; age, 4 wk) were weaned into groups (n = 10 to 24) and were euthanized at 4, 16, 22, 28, or 34 wk of age. At necropsy, high-resolution photographs of the 4 jaw quadrants were examined by 3 independent observers to determine the presence, number, and location of FIL...
February 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28219736/development-of-minimal-enzyme-cocktails-for-hydrolysis-of-sulfite-pulped-lignocellulosic-biomass
#20
Piotr Chylenski, Zarah Forsberg, Jerry Ståhlberg, Anikó Várnai, Martin Lersch, Oskar Bengtsson, Solve Sæbø, Svein Jarle Horn, Vincent G H Eijsink
Despite recent progress, saccharification of lignocellulosic biomass is still a major cost driver in biorefining. In this study, we present the development of minimal enzyme cocktails for hydrolysis of Norway spruce and sugarcane bagasse, which were pretreated using the so-called BALI™ process, which is based on sulfite pulping technology. Minimal enzyme cocktails were composed using several glycoside hydrolases purified from the industrially relevant filamentous fungus Trichoderma reesei and a purified commercial β-glucosidase from Aspergillus niger...
March 20, 2017: Journal of Biotechnology
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