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Platelet rich plasma

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https://www.readbyqxmd.com/read/28809630/aplikace-plazmy-obohacen%C3%A3-o-trombocyty-a-leukocyty-k-later%C3%A3-ln%C3%A3-mu-epikondylu-humeru
#1
P Walder, L Paša, L Pavliska
PURPOSE OF THE STUDY The aim of the study was to evaluate the safety and efficacy of the application of platelet- and leukocyte-rich plasma (L-PRP) in the treatment of lateral humeral epicondyle (ERH) as compared to the administration of corticosteroid therapy. MATERIAL AND METHODS It was a prospective, double-blind and randomized clinical trial. It included a total of 25 cases of ERH in 23 patients aged 18 to 60 years. They were divided into two arms: L-PRP arm with 10 cases and corticosteroid arm with 15 cases...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28807118/efficacy-of-autologous-platelet-rich-plasma-combined-with-hyaluronic-acid-on-skin-facial-rejuvenation-a-prospective-study
#2
Barbara Hersant, Mounia SidAhmed-Mezi, Jeremy Niddam, Simone La Padula, Warren Noel, Khaled Ezzedine, Anne Marie Rodriguez, Jean Paul Meningaud
No abstract text is available yet for this article.
September 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28806294/the-tissue-engineered-tendon-bone-interface-in-vitro-and-in-vivo-synergistic-effects-of-adipo-derived-stem-cells-platelet-rich-plasma-and-extracellular-matrix-hydrogel
#3
Rory McGoldrick, Arhana Chattopadhyay, Christopher Crowe, Grace Chiou, Kenneth Hui, Simon Farnebo, Christopher Davis, Anais Le Grand, Molly Jacobs, Hung Pham, James Chang
INTRODUCTION: Suboptimal healing of the tendon bone interface (TBI) remains an unsolved problem. One solution is a biocompatible tissue engineered construct that promotes augmented healing. We hypothesisze that 1.) the presence of Platelet Rich Plasma (PRP) and prolonged in vitro incubation produces tissue engineered tendon bone interface scaffolds with greater reseeding of viable Adipo-derived Stem Cells (ADSC) and 2.) when implanted with extracellular matrix hydrogel, constructs will display superior in vivo strength repair and biocompatibility...
August 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28806095/a-midterm-evaluation-of-postoperative-platelet-rich-plasma-injections-on-arthroscopic-supraspinatus-repair-a-randomized-controlled-trial
#4
Jay R Ebert, Allan Wang, Anne Smith, Robert Nairn, William Breidahl, Ming Hao Zheng, Timothy Ackland
BACKGROUND: Platelet-rich plasma (PRP) has been applied as an adjunct to rotator cuff repair to improve tendon-bone healing and potentially reduce the incidence of subsequent tendon retears. PURPOSE: To investigate whether the midterm clinical and radiographic outcomes of arthroscopic supraspinatus repair are enhanced after repeated postoperative applications of PRP. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: A total of 60 patients (30 control; 30 PRP) were initially randomized to receive 2 ultrasound-guided injections of PRP to the tendon repair site at 7 and 14 days after double-row arthroscopic supraspinatus repair or not...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28805478/production-of-platelet-rich-plasma-gel-from-elderly-patients-under-antithrombotic-drugs-perspectives-in-chronic-wounds-care
#5
M Velier, J Magalon, A Daumas, M Cassar, P Francois, A Ghazouane, C Philandrianos, B Bertrand, C Frere, D Bernot, P Villani, F Dignat George, F Sabatier
Platelet-Rich Plasma (PRP) is an autologous biological therapy obtained by centrifuging the patient's own blood to concentrate platelets. The addition of autologous thrombin and calcium chloride to PRP allows the production of a semi-solid form called PRP gel. PRP gel is increasingly used in a variety of tissue defects and predominantly in the management of non-healing chronic wounds. The topical application of PRP gel seems promising due to the capability of platelets to store and secrete growth factors (GF), fibrin and cytokines, which are essentials for wound healing...
August 14, 2017: Platelets
https://www.readbyqxmd.com/read/28804849/ristocetin-induced-platelet-aggregation-ripa-and-ripa-mixing-studies
#6
Juan Pablo Frontroth, Emmanuel J Favaloro
Ristocetin-induced platelet aggregation (RIPA) is used as an in vitro test to determine the presence and integrity of the platelet glycoprotein (GP) Ibα-V-IX complex and von Willebrand factor (VWF) interaction and is usually performed using platelet-rich plasma (PRP). Impairment in the response of VWF/GPIbα-V-IX is measured with reference to several established concentrations of ristocetin and may indicate defects in VWF or in GPIbα-V-IX function. RIPA-based mixing studies comprise an additional approach to testing this interaction to help define whether defects identified by RIPA lie in VWF or in GPIbα-V-IX...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28803906/viscosupplementation-for-hip-osteoarthritis-a-systematic-review-and-meta-analysis-of-the-efficacy-for-pain-disability-and-adverse-events
#7
REVIEW
Victor Figueiredo Leite, João Eduardo Daud Amadera, Anna Maria Buehler
OBJECTIVE: To assess the efficacy of viscosupplementation (HA) in hip osteoarthritis (OA) pain, disability and adverse events. DATA SOURCES: Pubmed, EMBASE, Cochrane Library, ClinicalTrials.gov database and specific journals up to March 2017. STUDY SELECTION: Randomized controlled trials comparing HA with any other intra-articular injection. DATA EXTRACTION: Performed according to Cochrane/GRADE criteria. Two authors extracted data, assessed risk of bias and quality of evidence...
August 10, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28802535/the-effects-of-autologous-platelet-rich-fibrin-on-flexor-tendon-healing-in-a-rabbit-model
#8
Janice C Y Liao, Min He, Aaron W T Gan, Alphonsus K S Chong
PURPOSE: Platelet-rich plasma containing large amounts of growth factors is purported to increase repaired flexor tendon strength. However, the use of bovine thrombin has the risk of antibody formation. We evaluated the effects of the newer generation autologous platelet-rich fibrin (PRF) on flexor tendon healing. METHODS: We performed surgical repair of 32 flexor tendons from the index and ring digits of the hind paws of 8 New Zealand white rabbits. In the PRF group, the PRF membrane was either wrapped around or interposed between the repair sites...
August 9, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28800920/does-platelet-rich-plasma-lead-to-earlier-return-to-sport-when-compared-with-conservative-treatment-in-acute-muscle-injuries-a-systematic-review-and-meta-analysis
#9
Ujash Sheth, Tim Dwyer, Ira Smith, David Wasserstein, John Theodoropoulos, Sachdeep Takhar, Jaskarndip Chahal
PURPOSE: To compare the time to return to sport and reinjury rate after platelet-rich plasma (PRP) injection versus control therapy (i.e., physiotherapy or placebo injection) in patients with acute grade I or II muscle strains. METHODS: All eligible studies comparing PRP against a control in the treatment of acute (≤7 days) grade I or II muscle strains were identified. The primary outcome was time to return to play. The secondary outcome was the rate of reinjury at a minimum of 6 months of follow-up...
August 8, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28798878/treatment-of-knee-osteochondral-lesions-using-a-novel-clot-of-autologous-plasma-rich-in-growth-factors-mixed-with-healthy-hyaline-cartilage-chips-and-intra-articular-injection-of-prgf
#10
Ramón Cugat, Eduard Alentorn-Geli, Gilbert Steinbacher, Pedro Álvarez-Díaz, Xavier Cuscó, Roberto Seijas, David Barastegui, Jordi Navarro, Patricia Laiz, Montserrat García-Balletbó
Knee cartilage or osteochondral lesions are common and challenging injuries. To date, most symptomatic lesions warrant surgical treatment. We present two cases of patients with knee osteochondral defects treated with a one-step surgical procedure consisting of an autologous-based matrix composed of healthy hyaline cartilage chips, mixed plasma poor-rich in platelets clot, and plasma rich in growth factors (PRGF). Both patients returned to playing soccer at the preinjury activity level and demonstrated excellent defect filling in both magnetic resonance imaging and second-look arthroscopy (in one of them)...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28797069/biodegradability-and-platelets-adhesion-assessment-of-magnesium-based-alloys-using-a-microfluidic-system
#11
Lumei Liu, Youngmi Koo, Boyce Collins, Zhigang Xu, Jagannathan Sankar, Yeoheung Yun
Magnesium (Mg)-based stents are extensively explored to alleviate atherosclerosis due to their biodegradability and relative hemocompatibility. To ensure the quality, safety and cost-efficacy of bioresorbable scaffolds and full utilization of the material tunability afforded by alloying, it is critical to access degradability and thrombosis potential of Mg-based alloys using improved in vitro models that mimic as closely as possible the in vivo microenvironment. In this study, we investigated biodegradation and initial thrombogenic behavior of Mg-based alloys at the interface between Mg alloys' surface and simulated physiological environment using a microfluidic system...
2017: PloS One
https://www.readbyqxmd.com/read/28792974/implicit-hype-representations-of-platelet-rich-plasma-in-the-news-media
#12
Christen Rachul, John E J Rasko, Timothy Caulfield
Platelet Rich Plasma (PRP) has gained popularity in recent years for treating sports-related injuries and the news media frequently reports on elite athletes' and celebrities' use of PRP. We conducted a content analysis of newspaper coverage of PRP in Australia, Canada, Ireland, New Zealand, United Kingdom, and the United States. Findings show that news media coverage of PRP appears most frequently in sports-related stories, and in relation to elite athletes use of PRP. PRP injections are largely portrayed as a routine treatment for sports-related injuries and newspaper articles rarely discuss the limitations or efficacy of PRP...
2017: PloS One
https://www.readbyqxmd.com/read/28792082/rotator-cuff-healing-using-demineralized-cancellous-bone-matrix-sponge-interposition-compared-to-standard-repair-in-a-preclinical-canine-model
#13
Matthew J Smith, Ferris M Pfeiffer, Cristi R Cook, Keiichi Kuroki, James L Cook
This Level II study assessed clinically relevant outcomes for repair of large, retracted infraspinatus tendons (ISTs) using a demineralized bone matrix (DBM) sponge (FlexiGraft) hydrated in platelet-rich plasma (PRP) versus direct repair in a validated canine model. Adult research dogs (n = 10) were used. The IST was transected in each shoulder (n = 20) and randomized to direct repair or repair with DBM-PRP interposition at 4 weeks posttransection. At 12 weeks postrepair, dogs were sacrificed, and the repair evaluated by magnetic resonance imaging (MRI), histology, and biomechanical testing...
August 9, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28791834/the-effect-of-platelet-rich-plasma-in-bone-tendon-integration
#14
İsmail Ağır, Mahmut Nedim Aytekin, Fatih Küçükdurmaz, Barış Kocaoğlu, Sule Çetinel, Mustafa Karahan
BACKGROUND: The operative reconstruction of a torn or insufficient anterior cruciate ligament has become a routine surgical procedure in orthopedics. The long-term success of an anterior cruciate ligament reconstruction depends on the ability of the graft to heal adequately in a bone tunnel. Investigators studying reconstructions described healing within a tunnel as osseous ingrowth and incorporation. In particular, helping the healing using autologous material for the best integration process was a new idea that helped us to set up this study...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28791607/treatment-of-dry-eye-disease-with-autologous-platelet-rich-plasma-a-prospective-interventional-non-randomized-study
#15
Jorge L Alio, Alejandra E Rodriguez, Renan Ferreira-Oliveira, Dominika Wróbel-Dudzińska, Ahmed A Abdelghany
INTRODUCTION: The objective of this study was to evaluate the use of autologous platelet-rich plasma (PRP) eye drops as monotherapy for the treatment of moderate to severe cases of dry eye disease. METHODS: Three hundred and sixty-eight patients with moderate to severe dry eye disease (DED) were included in this prospective case series. Subjects were classified as evaporative DED (EDED) or aqueous deficient DED (ADDED). Improvement of the DED subjective symptoms, corneal fluorescein staining (CFS), and corrected distance visual acuity (BCVA) were evaluated...
August 8, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28790378/hypoxia-impairs-agonist-induced-integrin-%C3%AE-iib%C3%AE-3-activation-and-platelet-aggregation
#16
Klytaimnistra Kiouptsi, Stepan Gambaryan, Elena Walter, Ulrich Walter, Kerstin Jurk, Christoph Reinhardt
Under ischemic conditions, tissues are exposed to hypoxia. Although human physiology, to a certain extent, can adapt to hypoxic conditions, the impact of low oxygen levels on platelet function is unresolved. Therefore, we explored how reduction of atmospheric oxygen levels to 1% might affect agonist-induced aggregation and static adhesion of isolated human platelets. We uncovered that isolated, washed human platelets exposed to hypoxic conditions show reduced thrombin receptor-activating peptide-6 (TRAP-6) and convulxin-induced aggregation...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783472/is-there-a-role-for-internal-bracing-and-repair-of-the-anterior-cruciate-ligament-a-systematic-literature-review
#17
Carola F van Eck, Orr Limpisvasti, Neal S ElAttrache
BACKGROUND: Renewed interest has arisen in arthroscopic anterior cruciate ligament (ACL) repair techniques. HYPOTHESIS: ACL repair with or without some form of internal bracing could lead to good outcomes in a carefully selected subset of patients. STUDY DESIGN: Systematic review. METHODS: An electronic database search was performed to identify 89 papers describing preclinical and clinical studies on the outcome of ACL repair...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28782384/skin-microneedling-plus-platelet-rich-plasma-versus-skin-microneedling-alone-in-the-treatment-of-atrophic-post-acne-scars-a-split-face-comparative-study
#18
Mohamed Kotb, Shady Mahmoud Ibrahim
INTRODUCTION: Acne scarring is a permanent disfiguring sequel, which can take varied morphological forms. Many therapeutic measures have been performed to improve acne scarring such as microneedling. Our objective is to evaluate the efficacy and safety of microneedling alone versus microneedling in combined with platelet rich plasma in the treatment of post acne Methods: The study included 35 patients with mild to severe post acne atrophic scar. All the patients received four sequential treatments of skin microneedling alone on the right side of the face and skin microneedling followed by topical application of PRP on the left side of the face with an interval of 3 weeks...
August 7, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28777978/clovamide-and-clovamide-rich-extracts-of-three-trifolium-species-as-antioxidants-and-moderate-antiplatelet-agents-in-vitro
#19
Joanna Kolodziejczyk-Czepas, Justyna Krzyżanowska-Kowalczyk, Malgorzata Sieradzka, Pawel Nowak, Anna Stochmal
This in vitro study provides a new insight into the phytochemical, antioxidant, antiplatelet and cytotoxic profiles of commercial trans-clovamide and clovamide-rich extracts, isolated from aerial parts of three Trifolium species (i.e. T. clypeatum L., T. obscurum Savi and T. squarrosum L.). Under inorganic experimental conditions, the EC50 for the investigated substances varied between 4.87 (clovamide) and 7.91 μg/ml (T. clypeatum) according to the DPPH(•) assay. The most effective 1 mM ONOO(-) scavenger was clovamide (IC50 = 19...
August 1, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28773189/evaluation-of-3d-printed-polycaprolactone-scaffolds-coated-with-freeze-dried-platelet-rich-plasma-for-bone-regeneration
#20
Junda Li, Meilin Chen, Xiaoying Wei, Yishan Hao, Jinming Wang
Three-dimensional printing is one of the most promising techniques for the manufacturing of scaffolds for bone tissue engineering. However, a pure scaffold is limited by its biological properties. Platelet-rich plasma (PRP) has been shown to have the potential to improve the osteogenic effect. In this study, we improved the biological properties of scaffolds by coating 3D-printed polycaprolactone (PCL) scaffolds with freeze-dried and traditionally prepared PRP, and we evaluated these scaffolds through in vitro and in vivo experiments...
July 19, 2017: Materials
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