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https://www.readbyqxmd.com/read/28183127/a-redescription-of-the-long-tailed-nesokia-i-nesokia-i-i-bunnii-i-and-designation-of-a-neotype-rodentia-muridae
#1
Boris Kryštufek, Omar F Al-Sheikhly, Rainer Hutterer
Long-tailed Nesokia, Nesokia bunnii, is a large rat restricted to the Mesopotamian marshes in Basra Province in southern Iraq. The species is known from five museum vouchers collected between March 1974 and January 1977. The type and the paratype, deposited in the Natural History Research Centre and Museum, University of Baghdad, Iraq, were destroyed during War on Iraq in 2003. By studying morphological details on three museum specimens in the Senckenberg Institution, Frankfurt a. M., Germany, we show that N...
January 4, 2017: Zootaxa
https://www.readbyqxmd.com/read/28178980/novel-neuro-audiological-findings-and-further-evidence-for-twnk-involvement-in-perrault-syndrome
#2
Monika Ołdak, Dominika Oziębło, Agnieszka Pollak, Iwona Stępniak, Michal Lazniewski, Urszula Lechowicz, Krzysztof Kochanek, Mariusz Furmanek, Grażyna Tacikowska, Dariusz Plewczynski, Tomasz Wolak, Rafał Płoski, Henryk Skarżyński
BACKGROUND: Hearing loss and ovarian dysfunction are key features of Perrault syndrome (PRLTS) but the clinical and pathophysiological features of hearing impairment in PRLTS individuals have not been addressed. Mutations in one of five different genes HSD17B4, HARS2, LARS2, CLPP or TWNK (previous symbol C10orf2) cause the autosomal recessive disorder but they are found only in about half of the patients. METHODS: We report on two siblings with a clinical picture resembling a severe, neurological type of PRLTS...
February 8, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28132411/a-case-report-of-disappearing-pigmented-skin-lesions-associated-with-pembrolizumab-treatment-for-metastatic-melanoma
#3
Z J Wolner, A A Marghoob, M P Pulitzer, M A Postow, M A Marchetti
Pembrolizumab is an immune checkpoint inhibitor that targets the programmed cell death (PD)-1 receptor. Common cutaneous adverse side effects of PD-1 inhibitors include maculopapular rash, pruritus, vitiligo, and lichenoid skin and mucosal reactions. Here, we describe a man in his sixties with metastatic melanoma treated with pembrolizumab who subsequently developed fading or disappearance of pigmented skin lesions, lightening of the skin, and poliosis of the eyebrows, eyelashes, and scalp and body hair. Compared to baseline high-resolution three-dimensional total body photography, we observed fading or disappearing of solar lentigines, seborrheic keratoses, and melanocytic naevi, suggesting that PD-1 inhibitors may affect the evolution of these benign skin lesions...
January 28, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28109001/polygonum-multiflorum-radix-extract-protects-human-foreskin-melanocytes-from-oxidative-stress-in-vitro-and-potentiates-hair-follicle-pigmentation-ex-vivo
#4
Peggy Sextius, Richard Betts, Ishak Benkhalifa, Stéphane Commo, Joan Eilstein, Marco Massironi, Ping Wang, Jean-Francois Michelet, Jie Qiu, Xuezhu Tan, Severine Jeulin
OBJECTIVE: To examine the ability of an extract from traditional Chinese medicine, Polygonum multiflorum Radix, to protect melanocyte viability from oxidative stress, a key mechanism in the initiation and progression of hair greying. METHODS: To assess the antioxidant capacity of Polygonum multiflorum Radix extract, primary human foreskin melanocytes were treated with a commercially available Polygonum multiflorum Radix extract added to culture medium and exposed to hydrogen peroxide (H2 O2 ), using intracellular reactive oxygen species concentrations and glutathione/protein ratios as endpoints...
January 20, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/27988355/agmatine-modulates-melanogenesis-via-mitf-signaling-pathway
#5
Eun-Jeong Kwon, Moon-Moo Kim
Agmatine contained in soybean is also found in Manaca, an anti-aging plant, inhabited in Amazon and induces vasodilation by the promotion of NO synthesis in blood vessel. However, the research of agmatine on melanin synthesis related to hair greying is lacking. The aim of this study was to investigate the melanogenic effect of agmatine via regulation of MITF signaling pathway in B16F1 cells. It was determined whether agmatine regulates melanin synthesis at cellular level in addition to the effect of agmatine on mushroom tyrosinase in vitro in the presence of different concentrations of agmatine...
January 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27939422/neuroprotective-effects-of-2-3-5-4-tetrahydoxystilbene-2-o-%C3%AE-d-glucoside-from-polygonum-multiflorum-against-glutamate-induced-oxidative-toxicity-in-ht22-cells
#6
Sun Young Lee, Sung Min Ahn, Ziyu Wang, Young Whan Choi, Hwa Kyoung Shin, Byung Tae Choi
ETHNOPHARMACOLOGICAL RELEVANCE: Since ancient times, Polygonum multiflorum Thunb. has been used to treat premature grey hair, dizziness, and blurred vision in East Asia. A major bioactive constituent of this medicinal herb, 2,3,5,4'-tetrahydoxystilbene-2-O-β-D-glucoside (THSG), has antioxidant activity and exerts beneficial effects on cognition and memory. AIM OF THE STUDY: The purpose of the current study was to determine if THSG affects hippocampal neuronal cell death and mitochondrial function following exposure to oxidative stress...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27917579/novel-technique-for-repigmentation-of-senescence-grey-hair
#7
Andy Goren, Željana Bolanča, Torello Lotti, Mirna Šitum
No abstract text is available yet for this article.
December 5, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27911893/the-mitochondrial-m-aaa-protease-prevents-demyelination-and-hair-greying
#8
Shuaiyu Wang, Julie Jacquemyn, Sara Murru, Paola Martinelli, Esther Barth, Thomas Langer, Carien M Niessen, Elena I Rugarli
The m-AAA protease preserves proteostasis of the inner mitochondrial membrane. It ensures a functional respiratory chain, by controlling the turnover of respiratory complex subunits and allowing mitochondrial translation, but other functions in mitochondria are conceivable. Mutations in genes encoding subunits of the m-AAA protease have been linked to various neurodegenerative diseases in humans, such as hereditary spastic paraplegia and spinocerebellar ataxia. While essential functions of the m-AAA protease for neuronal survival have been established, its role in adult glial cells remains enigmatic...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27878885/beware-when-the-hair-turns-dark-again-clinical-presentation-and-management-of-melanoma-in-situ-in-a-giant-congenital-naevus-on-the-scalp
#9
LETTER
D Crisan, K Scharffetter-Kochanek, R Dummer, N Treiber, A Sindrilaru, S Kastler, L A Schneider
No abstract text is available yet for this article.
November 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27833423/two-new-jumping-spider-species-of-the-habronattus-clypeatus-group-araneae-salticidae-harmochirina
#10
Wayne P Maddison, David R Maddison
Two species of the Habronattus clypeatus species group are described, Habronattus arcalorussp. n. from Texas and Colorado, and Habronattus gilaensissp. n. from New Mexico. Habronattus arcalorus males have extravagant ornamentation: a green first leg with an unusually dense lateral fringe of orange and white hairs, and a large grey triangular patella on the third leg with blue-white scales nearby. Habronattus gilaensis males are considerably more muted, lacking ornamentation on the third leg's patella and tibia...
2016: ZooKeys
https://www.readbyqxmd.com/read/27444138/hair-repigmentation-associated-with-thalidomide-use-for-the-treatment-of-multiple-myeloma
#11
Stephanie Lovering, Wenya Miao, Toni Bailie, Dominick Amato
A 75-year-old woman diagnosed with multiple myeloma in 2007 began treatment with monthly melphalan and prednisone for a total of 9 cycles in combination with thalidomide in 2009. The patient subsequently continued on thalidomide for long-term maintenance therapy. 3 years following initiation of thalidomide, the patient mentioned to her oncologist that her hair had become darker over the years. She attributed the change to thalidomide given the temporal relationship and progressive darkening over the course of therapy...
July 21, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27306139/in-search-of-hair-damage-using-metabolomics
#12
Gillian E Westgate
No abstract text is available yet for this article.
June 16, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27145515/boy-with-silvery-grey-hair-and-immunodeficiency
#13
(no author information available yet)
No abstract text is available yet for this article.
April 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27145514/boy-with-silvery-grey-hair-and-immunodeficiency
#14
Priti Khemka, Rajat Bhattacharyya, Swapan Ray, Mallar Mukherjee
No abstract text is available yet for this article.
April 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27144895/imaging-diagnosis-magnetic-resonance-imaging-and-histopathological-features-of-a-skull-base-chordoma-in-a-cat
#15
Josep Brocal, Virginia Gamino, Julien Guevar, Rodrigo Gutierrez-Quintana, Francesco Marchesi, Gawain Hammond, Catherine Stalin
An 8-year-old domestic short-haired cat was presented with anorexia, lethargy, ataxia and one episode of consciousness loss. A midline vertically orientated, biconcave, extra-axial mass originating from the basioccipital bone was detected on magnetic resonance images of the head. The mass was T1W iso- to hypointense when compared with normal grey matter, T2W hyperintense with small areas of isointensity and heterogeneously enhanced with contrast. Multiple signal voids were observed on T2* images. Histopathological evaluation confirmed a chordoma...
May 4, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27126766/-living-donor-liver-transplantation-for-the-treatment-complicated-hepatic-cystic-echinococcosis-first-case-report-from-china
#16
Y M Shao, W T Wang, Aji Tuerganaili, T Li, T M Jiang, R Q Zhang, Y B He, M Guo, L N Yan, H Wen
OBJECTIVE: To report the first clinical experience of living donor liver transplantation(LDLT) in patient with complicated hepatic cystic echinococcosis in China. METHODS: First Affiliated Hospital of Xinjiang Medical University successfully implemented LDLT in the treatment of one patient with complicated hepatic cystic echinococcosis after four times liver surgery and secondary congestive cirrhosis on May 9, 2015. The clinical data of the patient has been retrospectively analyzed...
April 26, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26977590/n-acetyl-cysteine-prevents-age-related-hearing-loss-and-the-progressive-loss-of-inner-hair-cells-in-%C3%AE-glutamyl-transferase-1-deficient-mice
#17
Dalian Ding, Haiyan Jiang, Guang-Di Chen, Chantal Longo-Guess, Vijaya Prakash Krishnan Muthaiah, Cong Tian, Adam Sheppard, Richard Salvi, Kenneth R Johnson
Genetic factors combined with oxidative stress are major determinants of age-related hearing loss (ARHL), one of the most prevalent disorders of the elderly. Dwarf grey mice, Ggt1dwg/dwg, are homozygous for a loss of function mutation of the g-glutamyl transferase 1 gene, which encodes an important antioxidant enzyme critical for the resynthesis of glutathione (GSH). Since GSH reduces oxidative damage, we hypothesized that Ggt1dwg/dwg mice would be susceptible to ARHL. Surprisingly, otoacoustic emissions and cochlear microphonic potentials, which reflect cochlear outer hair cell (OHC) function, were largely unaffected in mutant mice, whereas auditory brainstem responses and the compound action potential were grossly abnormal...
April 2016: Aging
https://www.readbyqxmd.com/read/26926045/a-genome-wide-association-scan-in-admixed-latin-americans-identifies-loci-influencing-facial-and-scalp-hair-features
#18
Kaustubh Adhikari, Tania Fontanil, Santiago Cal, Javier Mendoza-Revilla, Macarena Fuentes-Guajardo, Juan-Camilo Chacón-Duque, Farah Al-Saadi, Jeanette A Johansson, Mirsha Quinto-Sanchez, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Francisco M Salzano, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-José, Denis Headon, Carlos López-Otín, Desmond J Tobin, David Balding, Andrés Ruiz-Linares
We report a genome-wide association scan in over 6,000 Latin Americans for features of scalp hair (shape, colour, greying, balding) and facial hair (beard thickness, monobrow, eyebrow thickness). We found 18 signals of association reaching genome-wide significance (P values 5 × 10(-8) to 3 × 10(-119)), including 10 novel associations. These include novel loci for scalp hair shape and balding, and the first reported loci for hair greying, monobrow, eyebrow and beard thickness. A newly identified locus influencing hair shape includes a Q30R substitution in the Protease Serine S1 family member 53 (PRSS53)...
2016: Nature Communications
https://www.readbyqxmd.com/read/26861196/neuropathic-pain-induced-by-spinal-cord-injury-role-of-endothelin-eta-and-etb-receptors
#19
S Forner, A C Martini, E L de Andrade, G A Rae
Spinal cord injury (SCI) is a devastating neurologic disorder that often inflicts neuropathic pain, which further impacts negatively on the patient's quality of life. Endothelin peptides, which exert their effects via endothelin A (ETAR) and endothelin B (ETBR) receptors, can contribute to sensory changes associated with inflammatory and neuropathic pain, but their role in nociception following SCI is unknown. At different time points after subjecting male Wistar rats to surgery for compression-induced T10 level SCI, the spinal cord levels of ETAR and ETBR were assessed by Western blot and immunohistochemistry, and the corresponding mRNAs by real-time PCR, alongside recordings of behavioural responses to mechanical stimulation of the hind paws with von Frey hairs...
March 23, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26701933/over-expression-of-plk4-induces-centrosome-amplification-loss-of-primary-cilia-and-associated-tissue-hyperplasia-in-the-mouse
#20
Paula A Coelho, Leah Bury, Marta N Shahbazi, Kifayathullah Liakath-Ali, Peri H Tate, Sam Wormald, Christopher J Hindley, Meritxell Huch, Joy Archer, William C Skarnes, Magdalena Zernicka-Goetz, David M Glover
To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4). Over-expression of Plk4 from this transgene advances the onset of tumour formation that occurs in the absence of the tumour suppressor p53. Plk4 over-expression also leads to hyperproliferation of cells in the pancreas and skin that is enhanced in a p53 null background. Pancreatic islets become enlarged following Plk4 over-expression as a result of equal expansion of α- and β-cells, which exhibit centrosome amplification...
December 2015: Open Biology
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