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https://www.readbyqxmd.com/read/28859635/hair-cortisol-concentrations-correlate-negatively-with-survival-in-a-wild-primate-population
#1
Josué H Rakotoniaina, Peter M Kappeler, Eva Kaesler, Anni M Hämäläinen, Clemens Kirschbaum, Cornelia Kraus
BACKGROUND: Glucocorticoid hormones are known to play a key role in mediating a cascade of physiological responses to social and ecological stressors and can therefore influence animals' behaviour and ultimately fitness. Yet, how glucocorticoid levels are associated with reproductive success or survival in a natural setting has received little empirical attention so far. Here, we examined links between survival and levels of glucocorticoid in a small, short-lived primate, the grey mouse lemur (Microcebus murinus), using for the first time an indicator of long-term stress load (hair cortisol concentration)...
September 1, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28685843/oxidative-stress-management-in-the-hair-follicle-could-targeting-nrf2-counter-age-related-hair-disorders-and-beyond
#2
REVIEW
Laura Jadkauskaite, Pierre A Coulombe, Matthias Schäfer, Albena T Dinkova-Kostova, Ralf Paus, Iain S Haslam
Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition...
August 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28664230/cortical-thickness-abnormalities-in-trichotillomania-international-multi-site-analysis
#3
Samuel R Chamberlain, Michael Harries, Sarah A Redden, Nancy J Keuthen, Dan J Stein, Christine Lochner, Jon E Grant
Trichotillomania is a prevalent but often hidden psychiatric condition, characterized by repetitive hair pulling. The aim of this study was to confirm or refute structural brain abnormalities in trichotillomania by pooling all available global data. De-identified MRI scans were pooled by contacting authors of previous studies. Cortical thickness and sub-cortical volumes were compared between patients and controls. Patients (n = 76) and controls (n = 41) were well-matched in terms of demographic characteristics...
June 29, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28538897/do-you-know-this-syndrome-werner-syndrome
#4
Özlem Bilgiç
Werner syndrome is a rare autosomal recessive disorder, caused by mutations in the WRN gene. Clinical findings include: senile appearance, short stature, grey hair, alopecia, bird-like face, scleroderma-like skin changes, skin ulcers, voice abnormalities, cataracts, osteoporosis, type 2 diabetes mellitus, ischemic heart disease and hypogonadism. The syndrome begins to become apparent in adolescence but it is usually diagnosed in the third or fourth decade of life. Since the patients usually die by the age of 40-50 years related to malignant neoplasms or atherosclerotic complications, they should be closely followed and treated for complications...
March 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28456452/oral-mass-revealing-ch%C3%A3-diak-higashi-syndrome
#5
T Tsuji, Y Uemura, Y Nakamura, S Nonoyama
This case report describes common oral inflammatory findings leading to the identification of Chédiak-Higashi syndrome (CHS). A 15-year-old girl presented with an enlarging and painful mass on the upper lip. Two weeks after the initial visit, the mass showed further protrusion in the absence of fever. Magnetic resonance imaging revealed a well-circumscribed cystic lesion with a thick capsule, and suggested an abscess derived from the mucous cyst in the upper lip. Inflammation indices were not elevated; however neutrophils were significantly lower than the normal level...
September 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28451711/human-hair-baltic-grey-seal-halichoerus-grypus-fur-and-herring-gull-larus-argentatus-feathers-as-accumulators-of-bisphenol-a-and-alkylphenols
#6
Iga Nehring, Marta Staniszewska, Lucyna Falkowska
The purpose of the study was to determine the concentration of bisphenol A (BPA), 4-tert-octylphenol (OP), and 4-nonylphenol (NP), in human hair, the fur of Baltic grey seals and the feathers of herring gulls. Hair was collected from 42 volunteers, while grey seal fur (n = 17) came from the seal centre in Hel (Marine Station of Institute of Oceanography, University of Gdansk) and gull covert feathers (n = 26) were collected from dead herring gulls along the Southern Baltic coast. Assays of phenol derivatives were conducted using the high performance liquid chromatography with fluorescence detection technique...
May 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28386436/a-novel-locus-on-chromosome-1-underlies-the-evolution-of-a-melanic-plumage-polymorphism-in-a-wild-songbird
#7
Yann X C Bourgeois, Boris Delahaie, Mathieu Gautier, Emeline Lhuillier, Pierre-Jean G Malé, Joris A M Bertrand, Josselin Cornuault, Kazumasa Wakamatsu, Olivier Bouchez, Claire Mould, Jade Bruxaux, Hélène Holota, Borja Milá, Christophe Thébaud
Understanding the mechanisms responsible for phenotypic diversification within and among species ultimately rests with linking naturally occurring mutations to functionally and ecologically significant traits. Colour polymorphisms are of great interest in this context because discrete colour patterns within a population are often controlled by just a few genes in a common environment. We investigated how and why phenotypic diversity arose and persists in the Zosterops borbonicus white-eye of Reunion (Mascarene archipelago), a colour polymorphic songbird in which all highland populations contain individuals belonging to either a brown or a grey plumage morph...
February 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28358996/multiple-viral-plaques-with-sebaceous-differentiation-associated-with-an-unclassified-papillomavirus-type-in-a-cat
#8
J S Munday, S Marshall, N A Thomson, M Kiupel, R W Heathcott, A French
CASE HISTORY AND CLINICAL FINDINGS A 15-year-old neutered male domestic short-haired cat was presented due to multiple 0.5-2 cm-diameter crusting plaques in the left preauricular region, over the bridge of nose, and in the right periocular region. The plaques did not appear to cause discomfort. HISTOPATHOLOGICAL FINDINGS Biopsy samples of four plaques were examined histologically. Three plaques consisted of well-demarcated foci of mild epidermal hyperplasia overlying markedly hyperplastic sebaceous glands...
July 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28183127/a-redescription-of-the-long-tailed-nesokia-i-nesokia-i-i-bunnii-i-and-designation-of-a-neotype-rodentia-muridae
#9
Boris Kryštufek, Omar F Al-Sheikhly, Rainer Hutterer
Long-tailed Nesokia, Nesokia bunnii, is a large rat restricted to the Mesopotamian marshes in Basra Province in southern Iraq. The species is known from five museum vouchers collected between March 1974 and January 1977. The type and the paratype, deposited in the Natural History Research Centre and Museum, University of Baghdad, Iraq, were destroyed during War on Iraq in 2003. By studying morphological details on three museum specimens in the Senckenberg Institution, Frankfurt a. M., Germany, we show that N...
January 4, 2017: Zootaxa
https://www.readbyqxmd.com/read/28178980/novel-neuro-audiological-findings-and-further-evidence-for-twnk-involvement-in-perrault-syndrome
#10
Monika Ołdak, Dominika Oziębło, Agnieszka Pollak, Iwona Stępniak, Michal Lazniewski, Urszula Lechowicz, Krzysztof Kochanek, Mariusz Furmanek, Grażyna Tacikowska, Dariusz Plewczynski, Tomasz Wolak, Rafał Płoski, Henryk Skarżyński
BACKGROUND: Hearing loss and ovarian dysfunction are key features of Perrault syndrome (PRLTS) but the clinical and pathophysiological features of hearing impairment in PRLTS individuals have not been addressed. Mutations in one of five different genes HSD17B4, HARS2, LARS2, CLPP or TWNK (previous symbol C10orf2) cause the autosomal recessive disorder but they are found only in about half of the patients. METHODS: We report on two siblings with a clinical picture resembling a severe, neurological type of PRLTS...
February 8, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28132411/a-case-report-of-disappearing-pigmented-skin-lesions-associated-with-pembrolizumab-treatment-for-metastatic-melanoma
#11
Z J Wolner, A A Marghoob, M P Pulitzer, M A Postow, M A Marchetti
Pembrolizumab is an immune checkpoint inhibitor that targets the programmed cell death (PD)-1 receptor. Common cutaneous adverse side-effects of PD-1 inhibitors include maculopapular rash, pruritus, vitiligo and lichenoid skin and mucosal reactions. Here we describe a man in his sixties with metastatic melanoma treated with pembrolizumab who subsequently developed fading or disappearance of pigmented skin lesions, lightening of the skin, and poliosis of the eyebrows, eyelashes and scalp and body hair. Compared with baseline high-resolution three-dimensional total-body photography, we observed fading or disappearance of solar lentigines, seborrhoeic keratoses and melanocytic naevi, suggesting that PD-1 inhibitors may affect the evolution of these benign skin lesions...
January 28, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28109001/polygonum-multiflorum-radix-extract-protects-human-foreskin-melanocytes-from-oxidative-stress-in%C3%A2-vitro-and-potentiates-hair-follicle-pigmentation-ex%C3%A2-vivo
#12
P Sextius, R Betts, I Benkhalifa, S Commo, J Eilstein, M Massironi, P Wang, J-F Michelet, J Qiu, X Tan, S Jeulin
OBJECTIVE: To examine the ability of an extract from traditional Chinese medicine, Polygonum multiflorum Radix, to protect melanocyte viability from oxidative stress, a key mechanism in the initiation and progression of hair greying. METHODS: To assess the antioxidant capacity of Polygonum multiflorum Radix extract, primary human foreskin melanocytes were treated with a commercially available Polygonum multiflorum Radix extract added to culture medium and exposed to hydrogen peroxide (H2 O2 ), using intracellular reactive oxygen species concentrations and glutathione/protein ratios as endpoints...
January 20, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/27988355/agmatine-modulates-melanogenesis-via-mitf-signaling-pathway
#13
Eun-Jeong Kwon, Moon-Moo Kim
Agmatine contained in soybean is also found in Manaca, an anti-aging plant, inhabited in Amazon and induces vasodilation by the promotion of NO synthesis in blood vessel. However, the research of agmatine on melanin synthesis related to hair greying is lacking. The aim of this study was to investigate the melanogenic effect of agmatine via regulation of MITF signaling pathway in B16F1 cells. It was determined whether agmatine regulates melanin synthesis at cellular level in addition to the effect of agmatine on mushroom tyrosinase in vitro in the presence of different concentrations of agmatine...
January 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27939422/neuroprotective-effects-of-2-3-5-4-tetrahydoxystilbene-2-o-%C3%AE-d-glucoside-from-polygonum-multiflorum-against-glutamate-induced-oxidative-toxicity-in-ht22-cells
#14
Sun Young Lee, Sung Min Ahn, Ziyu Wang, Young Whan Choi, Hwa Kyoung Shin, Byung Tae Choi
ETHNOPHARMACOLOGICAL RELEVANCE: Since ancient times, Polygonum multiflorum Thunb. has been used to treat premature grey hair, dizziness, and blurred vision in East Asia. A major bioactive constituent of this medicinal herb, 2,3,5,4'-tetrahydoxystilbene-2-O-β-D-glucoside (THSG), has antioxidant activity and exerts beneficial effects on cognition and memory. AIM OF THE STUDY: The purpose of the current study was to determine if THSG affects hippocampal neuronal cell death and mitochondrial function following exposure to oxidative stress...
January 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27917579/novel-technique-for-repigmentation-of-senescence-grey-hair
#15
Andy Goren, Željana Bolanča, Torello Lotti, Mirna Šitum
No abstract text is available yet for this article.
March 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/27911893/the-mitochondrial-m-aaa-protease-prevents-demyelination-and-hair-greying
#16
Shuaiyu Wang, Julie Jacquemyn, Sara Murru, Paola Martinelli, Esther Barth, Thomas Langer, Carien M Niessen, Elena I Rugarli
The m-AAA protease preserves proteostasis of the inner mitochondrial membrane. It ensures a functional respiratory chain, by controlling the turnover of respiratory complex subunits and allowing mitochondrial translation, but other functions in mitochondria are conceivable. Mutations in genes encoding subunits of the m-AAA protease have been linked to various neurodegenerative diseases in humans, such as hereditary spastic paraplegia and spinocerebellar ataxia. While essential functions of the m-AAA protease for neuronal survival have been established, its role in adult glial cells remains enigmatic...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27878885/beware-when-the-hair-turns-dark-again-clinical-presentation-and-management-of-melanoma-in-situ-in-a-giant-congenital-naevus-on-the-scalp
#17
LETTER
D Crisan, K Scharffetter-Kochanek, R Dummer, N Treiber, A Sindrilaru, S Kastler, L A Schneider
No abstract text is available yet for this article.
November 23, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27833423/two-new-jumping-spider-species-of-the-habronattus-clypeatus-group-araneae-salticidae-harmochirina
#18
Wayne P Maddison, David R Maddison
Two species of the Habronattus clypeatus species group are described, Habronattus arcalorussp. n. from Texas and Colorado, and Habronattus gilaensissp. n. from New Mexico. Habronattus arcalorus males have extravagant ornamentation: a green first leg with an unusually dense lateral fringe of orange and white hairs, and a large grey triangular patella on the third leg with blue-white scales nearby. Habronattus gilaensis males are considerably more muted, lacking ornamentation on the third leg's patella and tibia...
2016: ZooKeys
https://www.readbyqxmd.com/read/27444138/hair-repigmentation-associated-with-thalidomide-use-for-the-treatment-of-multiple-myeloma
#19
Stephanie Lovering, Wenya Miao, Toni Bailie, Dominick Amato
A 75-year-old woman diagnosed with multiple myeloma in 2007 began treatment with monthly melphalan and prednisone for a total of 9 cycles in combination with thalidomide in 2009. The patient subsequently continued on thalidomide for long-term maintenance therapy. 3 years following initiation of thalidomide, the patient mentioned to her oncologist that her hair had become darker over the years. She attributed the change to thalidomide given the temporal relationship and progressive darkening over the course of therapy...
July 21, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27306139/in-search-of-hair-damage-using-metabolomics
#20
Gillian E Westgate
No abstract text is available yet for this article.
June 16, 2016: Experimental Dermatology
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