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JOURNAL ARTICLE
Zahra Goudarzi, Farhad Lotfi, Zhila Najafpour, AliAkbar Hafezi, Marzieh Alizadeh Zakaria, Khosro Keshavarz
INTRODUCTION: In recent years, enzalutamide and abiraterone have been widely used as treatments for metastatic castration-resistant prostate cancer (mCRPC). However, the cost-effectiveness of these drugs in Iran is unknown. This study evaluated the cost-effectiveness of enzalutamide for the treatment of metastatic prostate cancer resistant to castration in Iran. METHODS: A 3-state Markov model was developed to evaluate the cost-effectiveness of enzalutamide and abiraterone from a social perspective over 10 years...
February 20, 2024: BMC Urology
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JOURNAL ARTICLE
M Enes Aydemir, Nikki L Hafezi, Nan-Ji Lu, Emilio A Torres-Netto, Mark Hillen, Carina Koppen, Farhad Hafezi
PURPOSE: The purpose of this study was to determine if concurrent riboflavin/UV-A light (RF/UV-A) and rose Bengal/green light (RB/green) epi-off PACK-CXL enhances corneal resistance to enzymatic digestion compared to separate chromophore/light treatments. METHODS: Ex vivo porcine corneas were allocated as follows. Group A corneas were soaked with riboflavin (RF) and were either not irradiated (A1, controls) or were irradiated with 10 (A2) or 15 J/cm² (A3) UV-A light at 365 nm, respectively...
January 2, 2024: Translational Vision Science & Technology
#3
JOURNAL ARTICLE
Yara Bteich, Jad F Assaf, Jeremiah E Gendy, Fabian Müller, Soosan Jacob, Farhad Hafezi, Shady T Awwad
PURPOSE: To describe a novel technique for cutting asymmetric allogenic segments using the femtosecond laser for the management of cases of keratoconus with non-coinciding astigmatism and coma axes. METHODS: Four eyes of 2 patients with irregular keratoconus and asymmetric allogenic segments were included. Visual, refractive, tomographic, and aberrometric outcomes, and optical coherence tomography (OCT) sections were measured preoperatively and 6 months postoperatively...
December 2023: Journal of Refractive Surgery
#4
JOURNAL ARTICLE
Yara Bteich, Jad F Assaf, Anthony Abou Mrad, Soosan Jacob, Farhad Hafezi, Shady T Awwad
PURPOSE: To evaluate the visual, refractive, and tomographic results of patients with corneal ectasia treated with corneal allogenic intrastromal ring segments (CAIRS) insertion without concomitant corneal cross-linking. METHODS: Fifty-two eyes from 39 patients with stable corneal ectasia and unsatisfactory visual acuity with contact lenses were included. All patients underwent CAIRS insertion with no concomitant corneal procedure at the American University of Beirut Medical Center between September 2019 and July 2022...
November 2023: Journal of Refractive Surgery
#5
JOURNAL ARTICLE
Lily M Chacra, Chadi Helwe, Jad F Assaf, Madeleine Yehia, Serge Baroud, Emilio A Torres-Netto, Farhad Hafezi, Shady T Awwad
PURPOSE: To evaluate and compare functional and structural outcomes of accelerated cross-linking (A-CXL) using riboflavin with hydroxypropyl methyl cellulose (HPMC) versus conventional cross-linking (C-CXL) using Riboflavin with Dextran. SETTING: American University of Beirut Medical-Center, Lebanon. DESIGN: Retrospective Analysis. METHODS: Retrospective Analysis of 83 eyes of 73 patients with mild to moderate keratoconus...
October 20, 2023: Journal of Cataract and Refractive Surgery
#6
JOURNAL ARTICLE
Hagar Olshaker, Asaf Achiron, Alexander Chorny, Farhad Hafezi, Tal Yahalomi, Assaf Kratz, Erez Tsumi, Nan-Ji Lu, Boris Knyazer
Introduction: Photoactivated Chromophore for Infectious Keratitis-Corneal Cross-Linking (PACK-CXL) has garnered substantial interest among researchers and ophthalmologists due to its high promise as a potential treatment for infectious keratitis. The aim of this study is to evaluate the efficacy and safety of high fluence PACK-CXL, using 10.0 J/cm2 (30 mW/cm2 , 5 min, and 33 s) at the slit lamp. Methods: This prospective interventional, nonrandomized cohort study included 20 eyes of 20 patients with bacterial, fungal, or mixed origin keratitis who underwent high fluence PACK-CXL treatment as an adjunct therapy to conventional antimicrobial therapy per American Academy of Ophthalmology treatment guidelines...
2023: Frontiers in Pharmacology
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Farhad Hafezi, Emilio A Torres-Netto, Leonard Kollros, Nan-Ji Lu, Nikki Hafezi, Cosimo Mazzotta, M Enes Aydemir, Mark Hillen
No abstract text is available yet for this article.
September 25, 2023: Eye and Vision (London, England)
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JOURNAL ARTICLE
Nan-Ji Lu, Hendrik Koliwer-Brandl, Mark Hillen, Adrian Egli, Farhad Hafezi
PURPOSE: To investigate and compare the efficacy of high-fluence accelerated photoactivated chromophore for keratitis-corneal cross-linking (PACK-CXL) using either riboflavin/ultraviolet (UV)-A light or rose bengal/green light to treat Staphylococcus aureus or Pseudomonas aeruginosa infections in an ex vivo porcine cornea model. METHODS: One hundred and seventeen ex vivo porcine corneas were injected with clinical isolates of S. aureus or P. aeruginosa, divided into eight groups, and cultured for 24 hours...
September 1, 2023: Translational Vision Science & Technology
#9
JOURNAL ARTICLE
Farhad Hafezi, Emilio de Almeida Torres-Netto, Leonard Kollros, Nan-Ji Lu, Nikki Hafezi, Cosimo Mazzotta, M Enes Aydemir, Mark Hillen
BACKGROUND: This study aimed to compare the complication rates of epithelium-off corneal cross-linking (epi-off CXL) performed in an office-based setting with those of epi-off CXL performed in an operating room. METHODS: A retrospective cohort study, comprising 501 consecutive epi-off CXL procedures, performed in a non-sterile procedure room without laminar flow ventilation at the ELZA Institute in Zurich, Switzerland, between November 2015 and October 2021, was conducted...
September 1, 2023: Eye and Vision (London, England)
#10
JOURNAL ARTICLE
Nan-Ji Lu, Farhad Hafezi, Carina Koppen, Jorge L Alió Del Barrio, Ioannis M Aslanides, Shady T Awwad, Sorcha Ní Dhubhghaill, Roberto Pineda, Emilio A Torres-Netto, Lin Wang, Shi-Hao Chen, Le-Le Cui, Jos J Rozema
PURPOSE: To establish a numerical spectral-domain optical coherence tomography (SD-OCT)-based keratoconus (KC) staging system and compare it with existing KC staging systems. SETTING: Eye Hospital of Wenzhou Medical University, Wenzhou, China. DESIGNS: Retrospective case-control study. METHODS: Scheimpflug tomography, air-puff tonometry, and SD-OCT were performed on 236 normal and 331 KC eyes. All SD-OCT-derived parameters of the corneal epithelium and stroma were evaluated based on their receiver operating characteristic (ROC) curves, area under the curve (AUC), sensitivity, and specificity to discriminate between normal and KC eyes...
August 1, 2023: Journal of Cataract and Refractive Surgery
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EDITORIAL
Farhad Hafezi, Sholeh Jahanshahi
No abstract text is available yet for this article.
July 25, 2023: Aesthetic Surgery Journal
#12
REVIEW
Phulen Sarma, Hardeep Kaur, Farhad Hafezi, Jaimini Bhattacharyya, Richard Kirubakaran, Manisha Prajapat, Bikash Medhi, Kalyan Das, Ajay Prakash, Ashutosh Singh, Subodh Kumar, Rahul Singh, Dibbanti Harikrishna Reddy, Gurjeet Kaur, Saurabh Sharma, Anusuya Bhattacharyya
PURPOSE: The purpose of the study is to evaluate the safety and outcomes of corneal collagen cross-linking (CXL) and different CXL protocols in progressive keratoconus (PK) population at short and long-term. MATERIALS AND METHODS: A systematic review and meta-analysis was conducted. A total of eight literature databases were searched (up to February 15, 2022). Randomized controlled trials (RCTs) comparing CXL versus placebo/control or comparing different CXL protocols in the PK population were included...
2023: Taiwan Journal of Ophthalmology
#13
JOURNAL ARTICLE
Emilio A Torres-Netto, Hormoz Abdshahzadeh, Nan-Ji Lu, Sabine Kling, Reyhaneh Abrishamchi, Mark Hillen, Nikki Hafezi, Carina Koppen, Farhad Hafezi
PURPOSE: To assess whether sunlight might be used to induce a biomechanical stiffening effect in riboflavin-soaked corneas similar to the effect observed in corneal cross-linking using riboflavin and UV-A light. SETTING: Center for Applied Biotechnology and Molecular Medicine (CABMM), University of Zurich, Zurich, Switzerland. DESIGN: Experimental study. METHODS: Fifty-two porcine eyes were assayed. The concentration of riboflavin in the corneal stroma was estimated using UV-A transmission in a preliminary experiment...
June 19, 2023: Journal of Cataract and Refractive Surgery
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REVIEW
Farhad Hafezi, Emilio A Torres-Netto, Mark Hillen
PURPOSE OF REVIEW: The aim of this study was to summarize the recent developments in corneal cross-linking (CXL) and its indications, including corneal ectasias, refractive surgery and infectious keratitis. RECENT FINDINGS: Advances in CXL technology, such as the use of higher-intensity LED ultraviolet (UV) light sources and a better understanding of the UV-riboflavin photochemical reaction, have enabled safer and more effective methods of cross-linking thin and ultra-thin corneas, and more effective accelerated transepithelial/'epi-on' CXL procedures that are beginning to supplant the Dresden protocol as the 'gold standard' CXL method...
July 1, 2023: Current Opinion in Ophthalmology
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JOURNAL ARTICLE
José Alvaro P Gomes, Dimitri T Azar, Christophe Baudouin, Etty Bitton, Wei Chen, Farhad Hafezi, Pedram Hamrah, Ruth E Hogg, Jutta Horwath-Winter, Georgios A Kontadakis, Jodhbir S Mehta, Elisabeth M Messmer, Victor L Perez, David Zadok, Mark D P Willcox
The word "elective" refers to medications and procedures undertaken by choice or with a lower grade of prioritization. Patients usually use elective medications or undergo elective procedures to treat pathologic conditions or for cosmetic enhancement, impacting their lifestyle positively and, thus, improving their quality of life. However, those interventions can affect the homeostasis of the tear film and ocular surface. Consequently, they generate signs and symptoms that could impair the patient's quality of life...
April 20, 2023: Ocular Surface
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JOURNAL ARTICLE
Nan-Ji Lu, Carina Koppen, Farhad Hafezi, Sorcha Ní Dhubhghaill, Ioannis M Aslanides, Qin-Mei Wang, Le-Le Cui, Jos J Rozema
PURPOSE: To determine whether combinations of devices with different measuring principles, supported by artificial intelligence (AI), can improve the diagnosis of keratoconus (KC). METHODS: Scheimpflug tomography, spectral-domain optical coherence tomography (SD-OCT), and air-puff tonometry were performed in all eyes. The most relevant machine-derived parameters to diagnose KC were determined using feature selection. The normal and forme fruste KC (FFKC) eyes were divided into training and validation datasets...
April 12, 2023: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
#17
JOURNAL ARTICLE
Nan-Ji Lu, Farhad Hafezi, Emilio A Torres-Netto, Jad F Assaf, Ioannis M Aslanides, Shady T Awwad, Shihao Chen, Le-Le Cui, Carina Koppen
PURPOSE: The purpose of this study is to assess the effect of various fluence levels on prophylactic corneal cross-linking (CXL) combined with femtosecond laser in situ keratomileusis (FS-LASIK-Xtra) or transepithelial photorefractive keratectomy (TransPRK-Xtra) on biomechanics, demarcation line (DL), and stromal haze. METHODS: Prospective analysis where two prophylactic CXL protocols (lower/higher fluence [LF/HF]: 30 mw/cm2 , 60/80 s, 1.8/2.4 J/cm2 ) were performed as part of either an FS-LASIK-Xtra or TransPRK-Xtra procedure...
March 2023: Acta Ophthalmologica
#18
JOURNAL ARTICLE
Nan-Ji Lu, Hendrik Koliwer-Brandl, Francesca Gilardoni, Nikki Hafezi, Boris Knyazer, Asaf Achiron, Reinhard Zbinden, Adrian Egli, Farhad Hafezi
PURPOSE: To determine whether high-fluence photoactivated chromophore for keratitis cross-linking (PACK-CXL) can be accelerated. METHODS: Solutions of Staphylococcus aureus and Pseudomonas aeruginosa with 0.1% riboflavin were prepared and exposed to 365 nm ultraviolet (UV)-A irradiation of intensities and fluences from 9 to 30 mW/cm2 and from 5.4 to 15.0 J/cm2, respectively, representing nine different accelerated PACK-CXL protocols. Irradiated solutions and unirradiated controls were diluted, plated, and inoculated on agar plates so that the bacterial killing ratios (BKR) could be calculated...
February 1, 2023: Translational Vision Science & Technology
#19
JOURNAL ARTICLE
Emilio A Torres-Netto, Farhad Hafezi, Sabine Kling
No abstract text is available yet for this article.
January 2023: Journal of Refractive Surgery
#20
MULTICENTER STUDY
Renato Ambrósio, Aydano P Machado, Edileuza Leão, João Marcelo G Lyra, Marcella Q Salomão, Louise G Pellegrino Esporcatte, João B R da Fonseca Filho, Erica Ferreira-Meneses, Nelson B Sena, Jorge S Haddad, Alexandre Costa Neto, Gildasio Castelo de Almeida, Cynthia J Roberts, Ahmed Elsheikh, Riccardo Vinciguerra, Paolo Vinciguerra, Jens Bühren, Thomas Kohnen, Guy M Kezirian, Farhad Hafezi, Nikki L Hafezi, Emilio A Torres-Netto, Nanji Lu, David Sung Yong Kang, Omid Kermani, Shizuka Koh, Prema Padmanabhan, Suphi Taneri, William Trattler, Luca Gualdi, José Salgado-Borges, Fernando Faria-Correia, Elias Flockerzi, Berthold Seitz, Vishal Jhanji, Tommy C Y Chan, Pedro Manuel Baptista, Dan Z Reinstein, Timothy J Archer, Karolinne M Rocha, George O Waring, Ronald R Krueger, William J Dupps, Ramin Khoramnia, Hassan Hashemi, Soheila Asgari, Hamed Momeni-Moghaddam, Siamak Zarei-Ghanavati, Rohit Shetty, Pooja Khamar, Michael W Belin, Bernardo T Lopes
PURPOSE: To optimize artificial intelligence (AI) algorithms to integrate Scheimpflug-based corneal tomography and biomechanics to enhance ectasia detection. DESIGN: Multicenter cross-sectional case-control retrospective study. METHODS: A total of 3886 unoperated eyes from 3412 patients had Pentacam and Corvis ST (Oculus Optikgeräte GmbH) examinations. The database included 1 eye randomly selected from 1680 normal patients (N) and from 1181 "bilateral" keratoconus (KC) patients, along with 551 normal topography eyes from patients with very asymmetric ectasia (VAE-NT), and their 474 unoperated ectatic (VAE-E) eyes...
July 2023: American Journal of Ophthalmology
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