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JOURNAL ARTICLE
Giulia Collatuzzo, Jacqueline Cortez Lainez, Claudio Pelucchi, Eva Negri, Rossella Bonzi, Domenico Palli, Monica Ferraroni, Zuo-Feng Zhang, Guo-Pei Yu, Nuno Lunet, Samantha Morais, Lizbeth López-Carrillo, David Zaridze, Dmitry Maximovitch, Marcela Guevara, Vanessa Santos-Sanchez, Jesus Vioque, Manoli Garcia de la Hera, Mary H Ward, Reza Malekzadeh, Mohammadreza Pakseresht, Raúl Ulises Hernández-Ramírez, Federica Turati, Charles S Rabkin, Linda M Liao, Rashmi Sinha, Malaquias López-Cervantes, Shoichiro Tsugane, Akihisa Hidaka, M Constanza Camargo, Maria Paula Curado, Nadia Zubair, Dana Kristjansson, Shailja Shah, Carlo La Vecchia, Paolo Boffetta
PURPOSE: Gastric cancer (GC) is among the leading causes of cancer mortality worldwide. The objective of this study was to investigate the association between dietary fiber intake and GC. METHODS: We pooled data from 11 population or hospital-based case-control studies included in the Stomach Cancer Pooling (StoP) Project, for a total of 4865 histologically confirmed cases and 10,626 controls. Intake of dietary fibers and other dietary factors was collected using food frequency questionnaires...
April 30, 2024: European Journal of Nutrition
#2
JOURNAL ARTICLE
Thomas H Dohlman, Rohan Bir Singh, Francisco Amparo, Tatiana Carreno-Galeano, Mohammad Dastjerdi, Giulia Coco, Antonio Di Zazzo, Hasanain Shikari, Ujwala Saboo, Kimberly Sippel, Jessica Ciralsky, Sonia H Yoo, Matheus Sticca, Tais H Wakamatsu, Somasheila Murthy, Pedram Hamrah, Ula Jurkunas, Joseph B Ciolino, Hajirah Saeed, Jose A P Gomes, Victor L Perez, Jia Yin, Reza Dana
PURPOSE: To assess the effectiveness of topical and subconjunctival bevacizumab in suppressing vascularization in graft and host bed after high-risk corneal transplantation. DESIGN: Secondary analysis of prospective, randomized, double-blind, placebo-controlled multicentric clinical trial. PARTICIPANTS: The study includes patients aged > 18 years who underwent high-risk penetrating keratoplasty, which was defined as corneal vascularization in ≥ 1 quadrants of the corneal graft and host bed, excluding the limbus...
2024: Ophthalmol Sci
#3
JOURNAL ARTICLE
Mohammad G Zamani, Mohammad Reza Nikoo, Ghazi Al-Rawas, Rouzbeh Nazari, Dana Rastad, Amir H Gandomi
Water quality indicators (WQIs), such as chlorophyll-a (Chl-a) and dissolved oxygen (DO), are crucial for understanding and assessing the health of aquatic ecosystems. Precise prediction of these indicators is fundamental for the efficient administration of rivers, lakes, and reservoirs. This research utilized two unique DL algorithms-namely, convolutional neural network (CNNs) and gated recurrent units (GRUs)-alongside their amalgamation, CNN-GRU, to precisely gauge the concentration of these indicators within a reservoir...
April 9, 2024: Journal of Environmental Management
#4
JOURNAL ARTICLE
Pier Luigi Surico, Akitomo Narimatsu, Katayoon Forouzanfar, Rohan Bir Singh, Sara Shoushtari, Reza Dana, Tomas Blanco
Diabetes mellitus (DM) is one of the most prevalent diseases globally, and its prevalence is rapidly increasing. Most patients with a long-term history of DM present with some degree of keratopathy (DK). Despite its high incidence, the underlying inflammatory mechanism of DK has not been elucidated yet. For further insights into the underlying immunopathologic processes, we utilized streptozotocin-induced mice to model type 1 DM (T1D) and B6.Cg-Lepob/J mice to model type 2 DM (T2D). We evaluated the animals for the development of clinical manifestations of DK...
March 18, 2024: Cells
#5
JOURNAL ARTICLE
Pier Luigi Surico, Seokjoo Lee, Rohan Bir Singh, Amirreza Naderi, Shilpy Bhullar, Tomas Blanco, Yihe Chen, Reza Dana
Myeloid derived suppressor cells (MDSCs) are a heterogenous population of immature hematopoietic precursors with known immunoregulatory functions. The immunosuppressive role of MDSCs has been highlighted in several inflammatory ophthalmic disorders; however, their therapeutic application in suppressing the immune-mediated changes in dry eye disease (DED) has not been studied. We observed significant reduction in antigen presenting cell (APC) frequencies and their maturation in the presence of MDSCs. Moreover, co-culturing MDSCs with T helper 17 cells (Th17) resulted in reduced Th17 frequencies and their IL-17 expression...
March 26, 2024: Experimental Eye Research
#6
JOURNAL ARTICLE
Seokjoo Lee, Tomas Blanco, Aytan Musayeva, Shima Dehghani Ahmadabad, Akitomo Narimatsu, Katayoon Forouzanfar, Gustavo Ortiz, Francesca Kahale, Shudan Wang, Yihe Chen, Thomas H Dohlman, Sunil K Chauhan, Reza Dana
Highly inflamed and neovascularized corneal graft beds are known as high-risk environments for transplant survival. One of the primary factors leading to this rejection is reduction in the suppressive function of regulatory T cells (Treg). Our results show that myeloid-derived suppressor cells (MDSC) counteract IL-6-mediated Treg dysfunction by expressing IL-10. Additionally, MDSC maintain FoxP3 stability and their ability to suppress IFN-γ+ Th1 cells. Administering MDSC to high-risk corneal transplant recipients demonstrates prolonged graft survival via promotion of Treg while concurrently suppressing IFN-γ+ Th1 cells...
March 19, 2024: American Journal of Transplantation
#7
JOURNAL ARTICLE
Kevin Sheng-Kai Ma, Juien Lo, James Chodosh, Reza Dana
PURPOSE: To determine the risk and incidence of keratitis following treatment with epidermal growth factor receptor inhibitors (EGFRi) and subtypes of EGFRi-associated keratitis. METHODS: This multi-center cohort study included EGFRi-treated patients and non-users with lung cancer between 2010 and 2023. EGFRi included first-generation agent gefitinib and erlotinib, second-generation agent afatinib, and third-generation agent osimertinib. The primary outcome was new-onset keratitis...
March 18, 2024: Ocular Surface
#8
Daniel G Calame, Jovi Huixin Wong, Puravi Panda, Dat Tuan Nguyen, Nancy C P Leong, Riccardo Sangermano, Sohil G Patankar, Mohamed Abdel-Hamid, Lama AlAbdi, Sylvia Safwat, Kyle P Flannery, Zain Dardas, Jawid M Fatih, Chaya Murali, Varun Kannan, Timothy E Lotze, Isabella Herman, Farah Ammouri, Brianna Rezich, Stephanie Efthymiou, Shahryar Alavi, David Murphy, Zahra Firoozfar, Mahya Ebrahimi Nasab, Amir Bahreini, Majid Ghasemi, Nourelhoda A Haridy, Hamid Reza Goldouzi, Fatemeh Eghbal, Ehsan Ghayoor Karimiani, Varunvenkat M Srinivasan, Vykuntaraju K Gowda, Haowei Du, Shalini N Jhangiani, Zeynep Coban-Akdemir, Dana Marafi, Lance Rodan, Sedat Isikay, Jill A Rosenfeld, Subhadra Ramanathan, Michael Staton, Kerby C Oberg, Robin D Clark, Catharina Wenman, Sam Loughlin, Ramy Saad, Tazeen Ashraf, Alison Male, Shereen Tadros, Reza Boostani, Ghada M H Abdel-Salam, Maha Zaki, Ebtesam Abdalla, M Chiara Manzini, Davut Pehlivan, Jennifer E Posey, Richard A Gibbs, Henry Houlden, Fowzan S Alkuraya, Kinga Bujakowska, Reza Maroofian, James R Lupski, Long Nam Nguyen
FLVCR1 encodes Feline leukemia virus subgroup C receptor 1 (FLVCR1), a solute carrier (SLC) transporter within the Major Facilitator Superfamily. FLVCR1 is a widely expressed transmembrane protein with plasma membrane and mitochondrial isoforms implicated in heme, choline, and ethanolamine transport. While Flvcr1 knockout mice die in utero with skeletal malformations and defective erythropoiesis reminiscent of Diamond-Blackfan anemia, rare biallelic pathogenic FLVCR1 variants are linked to childhood or adult-onset neurodegeneration of the retina, spinal cord, and peripheral nervous system...
February 13, 2024: medRxiv
#9
REVIEW
Shudan Wang, Francesca Kahale, Amirreza Naderi, Pier Luigi Surico, Jia Yin, Thomas Dohlman, Yihe Chen, Reza Dana
Alpha-melanocyte-stimulating hormone (α-MSH) and its binding receptors (the melanocortin receptors) play important roles in maintaining ocular tissue integrity and immune homeostasis. Particularly extensive studies have demonstrated the biological functions of α-MSH in both immunoregulation and cyto-protection. This review summarizes the current knowledge of both the physiological and pathological roles of α-MSH and its receptors in the eye. We focus on recent developments in the biology of α-MSH and the relevant clinical implications in treating ocular diseases...
January 31, 2024: Biomolecules
#10
JOURNAL ARTICLE
Mohammed Almannai, Dana Marafi, Maha S Zaki, Reza Maroofian, Stephanie Efthymiou, Nebal Waill Saadi, Bilal Filimban, Hormos Salimi Dafsari, Fatima Rahman, Shazia Maqbool, Eissa Faqeih, Fuad Al Mutairi, Hind Alsharhan, Omar Abdelaty, Saadoun Bin-Hasan, Ruizhi Duan, Mahmoud M Noureldeen, Alaa Alqattan, Henry Houlden, Jill V Hunter, Jennifer E Posey, James R Lupski, Ayman W El-Hattab
PPP1R21 encodes for a conserved protein that is involved in endosomal maturation. Biallelic pathogenic variants in PPP1R21 have been associated with a syndromic neurodevelopmental disorder from studying 13 affected individuals. In this report, we present 11 additional individuals from nine unrelated families and their clinical, radiological, and molecular findings. We identified eight different variants in PPP1R21, of which six were novel variants. Global developmental delay and hypotonia are neurological features that were observed in all individuals...
February 14, 2024: Clinical Genetics
#11
JOURNAL ARTICLE
Ali Talebipour, Mehrdad Saviz, Mohaddeseh Vafaiee, Reza Faraji-Dana
In recent years, microscopy has revolutionized the study of dynamic living cells. However, performing long-term live cell imaging requires stable environmental conditions such as temperature, pH, and humidity. While standard incubators have traditionally provided these conditions, other solutions, like stagetop incubators are available. To further enhance the accessibility of stable cell culture environments for live cell imaging, we developed a portable CO2 cell culture mini-incubator that can be easily adapted to any x-y inverted microscope stage, enabling long-term live cell imaging...
February 10, 2024: Scientific Reports
#12
REVIEW
Sandra Perdomo, Behnoush Abedi-Ardekani, Ana Carolina de Carvalho, Aida Ferreiro-Iglesias, Valérie Gaborieau, Thomas Cattiaux, Hélène Renard, Priscilia Chopard, Christine Carreira, Andreea Spanu, Arash Nikmanesh, Ricardo Cortez Cardoso Penha, Samuel O Antwi, Patricia Ashton-Prolla, Cristina Canova, Taned Chitapanarux, Riley Cox, Maria Paula Curado, José Carlos de Oliveira, Charles Dzamalala, Elenora Fabianova, Lorenzo Ferri, Rebecca Fitzgerald, Lenka Foretova, Steven Gallinger, Alisa M Goldstein, Ivana Holcatova, Antonio Huertas, Vladimir Janout, Sonata Jarmalaite, Radka Kaneva, Luiz Paulo Kowalski, Tomislav Kulis, Pagona Lagiou, Jolanta Lissowska, Reza Malekzadeh, Dana Mates, Valerie McCorrmack, Diana Menya, Sharayu Mhatre, Blandina Theophil Mmbaga, André de Moricz, Péter Nyirády, Miodrag Ognjanovic, Kyriaki Papadopoulou, Jerry Polesel, Mark P Purdue, Stefan Rascu, Lidia Maria Rebolho Batista, Rui Manuel Reis, Luis Felipe Ribeiro Pinto, Paula A Rodríguez-Urrego, Surasak Sangkhathat, Suleeporn Sangrajrang, Tatsuhiro Shibata, Eduard Stakhovsky, Beata Świątkowska, Carlos Vaccaro, Jose Roberto Vasconcelos de Podesta, Naveen S Vasudev, Marta Vilensky, Jonathan Yeung, David Zaridze, Kazem Zendehdel, Ghislaine Scelo, Estelle Chanudet, Jingwei Wang, Stephen Fitzgerald, Calli Latimer, Sarah Moody, Laura Humphreys, Ludmil B Alexandrov, Michael R Stratton, Paul Brennan
Large-scale biorepositories and databases are essential to generate equitable, effective, and sustainable advances in cancer prevention, early detection, cancer therapy, cancer care, and surveillance. The Mutographs project has created a large genomic dataset and biorepository of over 7,800 cancer cases from 30 countries across five continents with extensive demographic, lifestyle, environmental, and clinical information. Whole-genome sequencing is being finalized for over 4,000 cases, with the primary goal of understanding the causes of cancer at eight anatomic sites...
January 31, 2024: Cell Genom
#13
JOURNAL ARTICLE
Shudan Wang, Sharad K Mittal, Seokjoo Lee, Antonio Esquivel Herrera, Mark Krauthammer, Elsayed Elbasiony, Tomas Blanco, Hamid Alemi, Hayate Nakagawa, Sunil K Chauhan, Reza Dana, Thomas H Dohlman
PURPOSE: To evaluate whether fibrosis contributes to corneal transplant failure and to determine whether effector CD4+ T cells, the key immune cells in corneal transplant rejection, play a direct role in fibrosis formation. METHODS: Allogeneic corneal transplantation was performed in mice. Graft opacity was evaluated by slit-lamp biomicroscopy, and fibrosis was assessed by in vivo confocal microscopy. Expression of alpha-smooth muscle actin (α-SMA) in both accepted and failed grafts was assessed by real-time PCR and immunohistochemistry...
January 2, 2024: Investigative Ophthalmology & Visual Science
#14
Avinash V Dharmadhikari, Maria Alba Abad, Sheraz Khan, Reza Maroofian, Tristan T Sands, Farid Ullah, Itaru Samejima, Martin A Wear, Kiara E Moore, Elena Kondakova, Natalia Mitina, Theres Schaub, Grace K Lee, Christine H Umandap, Sara M Berger, Alejandro D Iglesias, Bernt Popp, Rami Abou Jamra, Heinz Gabriel, Stefan Rentas, Alyssa L Rippert, Kosuke Izumi, Laura K Conlin, Daniel C Koboldt, Theresa Mihalic Mosher, Scott E Hickey, Dara V F Albert, Haley Norwood, Amy Feldman Lewanda, Hongzheng Dai, Pengfei Liu, Tadahiro Mitani, Dana Marafi, Davut Pehlivan, Jennifer E Posey, Natalie Lippa, Natalie Vena, Erin L Heinzen, David B Goldstein, Cyril Mignot, Jean-Madeleine de Sainte Agathe, Nouriya Abbas Al-Sannaa, Mina Zamani, Saeid Sadeghian, Reza Azizimalamiri, Tahere Seifia, Maha S Zaki, Ghada M H Abdel-Salam, Mohamed Abdel-Hamid, Lama Alabdi, Fowzan Sami Alkuraya, Heba Dawoud, Aya Lofty, Peter Bauer, Giovanni Zifarelli, Erum Afzal, Faisal Zafar, Stephanie Efthymiou, Daniel Gossett, Meghan C Towne, Raey Yeneabat, Sandeep N Wontakal, Vimla S Aggarwal, Jill A Rosenfeld, Victor Tarabykin, Shinya Ohta, James R Lupski, Henry Houlden, William C Earnshaw, Erica E Davis, A Arockia Jeyaprakash, Jun Liao
SPOUT1/CENP-32 encodes a putative SPOUT RNA methyltransferase previously identified as a mitotic chromosome associated protein. SPOUT1/CENP-32 depletion leads to centrosome detachment from the spindle poles and chromosome misalignment. Aided by gene matching platforms, we identified 24 individuals with neurodevelopmental delays from 18 families with bi-allelic variants in SPOUT1/CENP-32 detected by exome/genome sequencing. Zebrafish spout1/cenp-32 mutants showed reduction in larval head size with concomitant apoptosis likely associated with altered cell cycle progression...
January 9, 2024: medRxiv
#15
JOURNAL ARTICLE
Xi Chen, Shima Gholizadeh, Mahsa Ghovvati, Ziqing Wang, Marcus J Jellen, Azadeh Mostafavi, Reza Dana, Nasim Annabi
Ocular inflammation is commonly associated with eye disease or injury. Effective and sustained ocular delivery of therapeutics remains a challenge due to the eye physiology and structural barriers. Herein, we engineered a photocrosslinkable adhesive patch (GelPatch) incorporated with micelles (MCs) loaded with Loteprednol etabonate (LE) for delivery and sustained release of drug. The engineered drug loaded adhesive hydrogel, with controlled physical properties, provided a matrix with high adhesion to the ocular surfaces...
June 2023: AIChE Journal
#16
JOURNAL ARTICLE
Pin-Chia Huang, Ching-Chieh Lin, Reza Dana, Kevin Sheng-Kai Ma
IMPORTANCE: Epidermal growth factor receptor inhibitors (EGFRis) have been reported to be associated with cutaneous and ocular side effects; however, there is limited evidence of an association between EGFRi treatment and keratitis. OBJECTIVE: To determine the association between EGFRi treatment and agents and the risk of new-onset keratitis among patients with lung cancer. DESIGN, SETTING, AND PARTICIPANTS: This US population-based cohort study examined TriNetX data of patients with lung cancer treated with or without EGFRis between May 1, 2003, and October 30, 2023...
January 11, 2024: JAMA Ophthalmology
#17
JOURNAL ARTICLE
Bshair Aldriweesh, Ahmed Alkhateeb, An Boudewyns, Ching Yee Chan, Robert H Chun, Hamdy G El-Hakim, Pierre Fayoux, Mark E Gerber, Sohit Kanotra, Kimberley Kaspy, Haytham Kubba, Elton M Lambert, Romain Luscan, Sanjay R Parikh, Reza Rahbar, Scott M Rickert, John Russell, Mike Rutter, James W Schroeder, Yehuda Schwarz, Steven E Sobol, Ravi Thevasagayam, Briac Thierry, Dana M Thompson, Taher Valika, Karen Watters, Julie L Wei, Michelle Wyatt, Karen B Zur, Sam J Daniel
OBJECTIVE: To provide recommendations for a comprehensive management approach for infants and children presenting with symptoms or signs of aspiration. METHODS: Three rounds of surveys were sent to authors from 23 institutions worldwide. The threshold for the critical level of agreement among respondents was set at 80 %. To develop the definition of "intractable aspiration," each author was first asked to define the condition. Second, each author was asked to complete a 5-point Likert scale to specify the level of agreement with the definition derived in the first step...
January 2024: International Journal of Pediatric Otorhinolaryngology
#18
JOURNAL ARTICLE
Yukako Taketani, Shima Dehghani, Shruti Sinha, Suzanne K Freitag, George Papaliodis, Stephen Foster, Thomas H Dohlman, Reza Dana
PURPOSE: The aim of this study was to report a series of 3 patients with ocular graft-versus-host disease (oGVHD) with progressive cicatricial conjunctival changes who were diagnosed with ocular cicatricial pemphigoid (OCP) after conjunctival biopsy. METHODS: This study was a retrospective case series. RESULTS: Three patients who received hematopoietic stem cell transplantation for hematologic malignancies developed oGVHD and subsequently were diagnosed with OCP...
December 21, 2023: Cornea
#19
REVIEW
Seyyed Mohammad Matin Alavi-Dana, Yazdan Gholami, Mohammadreza Meghdadi, Mohammad Saleh Fadaei, Vahid Reza Askari
COVID-19 emerged in December 2019 in Wuhan, China, spread worldwide rapidly, and caused millions of deaths in a short time. Many preclinical and clinical studies were performed to discover the most efficient therapy to reduce the mortality of COVID-19 patients. Among various approaches for preventing and treating COVID-19, mesenchymal stem cell (MSC) therapy can be regarded as a novel and efficient treatment for managing COVID-19 patients. In this review, we explain the pathogenesis of COVID-19 infection in humans and discuss the role of MSCs in suppressing the inflammation and cytokine storm produced by COVID-19...
December 20, 2023: Inflammopharmacology
#20
JOURNAL ARTICLE
Najmeh Jooyan, Seyed Mohammad Javad Mortazavi, Bahram Goliaei, Reza Faraji-Dana
BACKGROUND: The global need for wireless technologies is growing rapidly. So, we have been exposed to a new type of environmental pollution: radiofrequency radiation (RFR). Recent studies have shown that RFR can cause not only direct effects but also indirect or non-targeted effects such as the bystander effect (BE). In this study, we investigated the BE induced by RFR in the present of gold nanoparticles (GNP). Moreover, we studied the expression of cyclooxygenase-2 (COX-2). METHODS: Non-toxic dose of 15-nm GNP was used to treat the Chinese Hamster Ovary (CHO) cells...
December 11, 2023: Chemosphere
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