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https://www.readbyqxmd.com/read/27899224/interleukin-7-and-15-maintain-pathogenic-memory-th17-cells-in-autoimmunity
#1
Yihe Chen, Sunil K Chauhan, Xuhua Tan, Reza Dana
Th17 cells are principal mediators of many autoimmune conditions. Recently, memory Th17 cells have been revealed as crucial in mediating the chronicity of various refractory autoimmune disorders; however, the underlying mechanisms maintaining memory Th17 cells have remained elusive. Here, using a preclinical model of ocular autoimmune disease we show that both IL-7 and IL-15 are critical for maintaining pathogenic memory Th17 cells. Neutralization of these cytokines leads to substantial reduction of memory Th17 cells; both IL-7 and IL-15 provide survival signals via activating STAT5, and IL-15 provides additional proliferation signals via activating both STAT5 and Akt...
November 26, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27811567/patients-with-dry-eye-disease-and-low-subbasal-nerve-density-are-at-high-risk-for-accelerated-corneal-endothelial-cell-loss
#2
Ahmad Kheirkhah, Vannarut Satitpitakul, Pedram Hamrah, Reza Dana
PURPOSE: To evaluate changes in corneal endothelial cell density over time in patients with dry eye disease (DED) and to correlate endothelial cell loss with corneal subbasal nerve density. METHODS: This retrospective study included 40 eyes of 20 patients with DED. Laser in vivo confocal microscopy had been performed in the central cornea of both eyes at an initial visit and repeated after a mean follow-up of 33.2 ± 10.2 months. The densities of corneal endothelial cells and subbasal nerves were measured in both visits and compared with 13 eyes of 13 normal age-matched controls...
November 2, 2016: Cornea
https://www.readbyqxmd.com/read/27770942/an-electrical-bio-chip-to-transfer-and-detect-electromagnetic-stimulation-on-the-cells-based-on-vertically-aligned-carbon-nanotubes
#3
Saeed Rafizadeh-Tafti, Mohammad Hossein Haqiqatkhah, Mehrdad Saviz, Mohsen Janmaleki, Reza Faraji Dana, Somayeh Zanganeh, Mohammad Abdolahad
A highly sensitive impedimetric bio-chip based on vertically aligned multiwall carbon nanotubes (VAMWCNTs), was applied in direct interaction with lung cancer cells. Our tool provided both inducing and monitoring the bioelectrical changes in the cells initiated by electromagnetic (EM) wave stimulation. EM wave of 940MHz frequency with different intensities was used. Here, wave ablation might accumulate electrical charge on the tips of nanotubes penetrated into cell's membrane. The charge might induce ionic exchanges into the cell and cause alterations in electrical states of the membrane...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27660330/optimising-keratoplasty-for-peters-anomaly-in-infants-using-spectral-domain-optical-coherence-tomography
#4
Jiaxu Hong, Yujing Yang, Claus Cursiefen, Alireza Mashaghi, Dan Wu, Zuguo Liu, Xinghuai Sun, Reza Dana, Jianjiang Xu
PURPOSE: To present in vivo anterior segment optical coherence tomography (OCT) features of infants with Peters' anomaly obtained during presurgical examination under general anaesthesia, and to evaluate the impact of OCT features on surgical decision making. METHODS: This is a single-centre, consecutive, observational case series including 44 eyes of 27 infants with Peters' anomaly (5-18 months) undergoing keratoplasty. Medical records of patients were reviewed retrospectively...
September 22, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27631349/novel-insights-into-the-immunoregulatory-function-and-localization-of-dendritic-cells
#5
Takaaki Hattori, Hiroki Takahashi, Reza Dana
Dendritic cells (DCs) are antigen-presenting cells that normally play a critical role in stimulating T-cell-dependent immune responses. However, tolerogenic DCs (CD11cMHC-IICD80CD86) induce immune tolerance by stimulating regulatory T cells (Tregs: CD4CD25Foxp3). Although tolerogenic DCs are used to treat autoimmune diseases and to prevent transplantation rejection, the mechanisms by which they regulate alloimmunity are poorly understood. Here, we review our previous studies aiming to elucidate the mechanisms involved in immune rejection of corneal allografts using a corneal transplant model...
November 2016: Cornea
https://www.readbyqxmd.com/read/27607414/in-vivo-confocal-microscopy-in-dry-eye-disease-associated-with-chronic-graft-versus-host-disease
#6
Ahmad Kheirkhah, Yureeda Qazi, Michael A Arnoldner, Kunal Suri, Reza Dana
PURPOSE: To compare densities of corneal epithelial dendritic cells (DCs), corneal subbasal nerves, and conjunctival epithelial immune cells (EICs) between patients with dry eye disease (DED) with and without graft-versus-host disease (GVHD) using in vivo confocal microscopy (IVCM). METHODS: This study included 54 patients who had moderate to severe DED either associated with (n = 33) or without (n = 21) chronic GVHD. In addition to evaluating clinical parameters of DED, images obtained by laser-scanning IVCM of the central cornea and superior tarsal conjunctiva were analyzed to measure densities of corneal epithelial DCs, corneal subbasal nerves, and conjunctival EICs...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27490416/proangiogenic-function-of-t-cells-in-corneal-transplantation
#7
Antonio Di Zazzo, Maryam Tahvildari, Brinda Subbarayal, Jia Yin, Thomas H Dohlman, Takenori Inomata, Alireza Mashaghi, Sunil K Chauhan, Reza Dana
BACKGROUND: Corneal neovascularization increases the risk of T cell mediated allograft rejection. Here, we investigate whether T cells promote angiogenesis in transplantation. METHODS: Conventional effector T cells were collected from draining lymph nodes (DLNs) of allogeneic or syngeneic corneal transplanted BALB/c mice. T cells were either cocultured with vascular endothelial cells (VECs) to assess VEC proliferation or used in a Mixed Lymphocyte Reaction assay...
August 3, 2016: Transplantation
https://www.readbyqxmd.com/read/27442322/ocular-manifestations-of-inherited-phospholipase-c%C3%AE-2-associated-antibody-deficiency-and-immune-dysregulation
#8
Antonio Di Zazzo, Maryam Tahvildari, George J Florakis, Reza Dana
PURPOSE: To report the ocular manifestations of phospholipase-Cγ2-associated antibody deficiency and immune dysregulation (PLAID). METHODS: Case report and literature review. RESULTS: A 21-year-old woman diagnosed with PLAID was referred for evaluation of repeated episodes of ocular inflammation resulting in bilateral peripheral corneal pannus with episcleritis and corneal scarring accompanied by systemic manifestations including epidermolysis bullosa and interstitial lung disease...
July 20, 2016: Cornea
https://www.readbyqxmd.com/read/27395775/patients-perspectives-on-their-dry-eye-disease
#9
Alja Crnej, Ahmad Kheirkhah, Ai Ren, Andrew Mullins, Alenka Lavric, Kunal Suri, Reza Dana
PURPOSE: Although it has been known that patients' perspectives on their disease can significantly affect their level of functional disability as well as disease outcome, limited data are available on patients' perceptions of their dry eye disease (DED). The aim of this questionnaire-based study was to evaluate patients' perspectives on their DED. METHODS: This cross-sectional study included 91 patients with DED. In addition to clinical evaluation, all patients completed a questionnaire to evaluate their perspectives on their DED...
July 6, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27378485/ageing-and-ocular-surface-immunity
#10
Alireza Mashaghi, Jiaxu Hong, Sunil K Chauhan, Reza Dana
The prevalence of ocular surface immunopathologies is enhanced in the elderly. This increased prevalence has been attributed to age-related dysregulation of innate and adaptive immune system responses. Age-related changes in ocular surface immunity have similar and distinct characteristics to those changes seen in other mucosal tissues. This mini review provides a brief outline of key findings in the field of ocular ageing, draws comparisons with other mucosal tissues and, finally, discusses age-related changes in the context of immunopathogenesis of infectious keratitis and dry eye disease, two of the most common inflammatory disorders of the ocular surface...
July 4, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27314883/neuropeptide-substance-p-and-the-immune-response
#11
REVIEW
Alireza Mashaghi, Anna Marmalidou, Mohsen Tehrani, Peter M Grace, Charalabos Pothoulakis, Reza Dana
Substance P is a peptide mainly secreted by neurons and is involved in many biological processes, including nociception and inflammation. Animal models have provided insights into the biology of this peptide and offered compelling evidence for the importance of substance P in cell-to-cell communication by either paracrine or endocrine signaling. Substance P mediates interactions between neurons and immune cells, with nerve-derived substance P modulating immune cell proliferation rates and cytokine production...
November 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27281559/clinical-implications-of-the-pharmacokinetics-of-crizotinib-in-populations-of-patients-with-non-small-cell-lung-cancer
#12
Erjian Wang, Dana J Nickens, Akintunde Bello, Reza Khosravan, Michael Amantea, Keith D Wilner, Kourosh Parivar, Weiwei Tan
PURPOSE: We assessed the effect of baseline patient demographic and disease characteristics on the crizotinib pharmacokinetic parameters oral clearance (CL/F), volume of distribution (V2/F), and area under the curve at steady state (AUCss) following multiple crizotinib 250-mg twice-daily dosing in patients with ALK-positive cancer. EXPERIMENTAL DESIGN: A pharmacokinetic model was fit to data from 1,214 patients. We identified statistically significant covariates (P ≤ 0...
December 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27183635/alloimmunity-and-tolerance-in-corneal-transplantation
#13
REVIEW
Afsaneh Amouzegar, Sunil K Chauhan, Reza Dana
Corneal transplantation is one of the most prevalent and successful forms of solid tissue transplantation. Despite favorable outcomes, immune-mediated graft rejection remains the major cause of corneal allograft failure. Although low-risk graft recipients with uninflamed graft beds enjoy a success rate ∼90%, the rejection rates in inflamed graft beds or high-risk recipients often exceed 50%, despite maximal immune suppression. In this review, we discuss the critical facets of corneal alloimmunity, including immune and angiogenic privilege, mechanisms of allosensitization, cellular and molecular mediators of graft rejection, and allotolerance induction...
May 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27132195/international-pediatric-otolaryngology-group-ipog-consensus-recommendations-routine-peri-operative-pediatric-tracheotomy-care
#14
Julie E Strychowsky, David Albert, Kenny Chan, Alan Cheng, Sam J Daniel, Alessandro De Alarcon, Noel Garabedian, Catherine Hart, Christopher Hartnick, Andy Inglis, Ian Jacobs, Monica E Kleinman, Nilesh M Mehta, Richard Nicollas, Roger Nuss, Seth Pransky, John Russell, Mike Rutter, Anne Schilder, Dana Thompson, Jean-Michel Triglia, Mark Volk, Bob Ward, Karen Watters, Michelle Wyatt, George Zalzal, Karen Zur, Reza Rahbar
OBJECTIVES: To develop consensus recommendations for peri-operative tracheotomy care in pediatric patients. METHODS: Expert opinion by the members of the International Pediatric Otolaryngology Group (IPOG). The mission of the IPOG is to develop expertise-based consensus recommendations for the management of pediatric otolaryngologic disorders with the goal of improving patient care. The consensus recommendations herein represent the first publication by the group...
July 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27107728/international-pediatric-orl-group-ipog-laryngomalacia-consensus-recommendations
#15
REVIEW
John Carter, Reza Rahbar, Matthew Brigger, Kenny Chan, Alan Cheng, Sam J Daniel, Alessandro De Alarcon, Noel Garabedian, Catherine Hart, Christopher Hartnick, Ian Jacobs, Bryan Liming, Richard Nicollas, Seth Pransky, Gresham Richter, John Russell, Michael J Rutter, Anne Schilder, Richard J H Smith, Julie Strychowsky, Robert Ward, Karen Watters, Michelle Wyatt, George Zalzal, Karen Zur, Dana Thompson
OBJECTIVE: To provide recommendations for the comprehensive management of young infants who present with signs or symptoms concerning for laryngomalacia. METHODS: Expert opinion by the members of the International Pediatric Otolaryngology Group (IPOG). RESULTS: Consensus recommendations include initial care and triage recommendations for health care providers who commonly evaluate young infants with noisy breathing. The consensus statement also provides comprehensive care recommendations for otolaryngologists who manage young infants with laryngomalacia including: evaluation and treatment considerations for commonly debated issues in laryngomalacia, initial work-up of infants presenting with inspiratory stridor, treatment recommendations based on disease severity, management of the infant with feeding difficulties, post-surgical treatment management recommendations, and suggestions for acid suppression therapy...
July 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27107348/corrigendum-to-corneal-innervation-as-a-window-to-peripheral-neuropathies-exp-eye-res-113-2013-148-150
#16
Giulio Ferrari, Nambi Nallasamy, Heather Downs, Reza Dana, Anne Louise Oaklander
No abstract text is available yet for this article.
April 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27089999/validity-and-reliability-of-a-novel-ocular-pain-assessment-survey-opas-in-quantifying-and-monitoring-corneal-and-ocular-surface-pain
#17
Yureeda Qazi, Shelley Hurwitz, Sarosh Khan, Ula V Jurkunas, Reza Dana, Pedram Hamrah
PURPOSE: To validate the Ocular Pain Assessment Survey (OPAS), specifically designed to measure ocular pain and quality of life for use by eye care practitioners and researchers. DESIGN: A single-center cohort study was conducted among patients with and without corneal and ocular surface pain at initial and follow-up visits over a 6-month period. The content of the OPAS was guided by literature review, a body of experts, and incorporating conceptual frameworks from existing pain questionnaires...
July 2016: Ophthalmology
https://www.readbyqxmd.com/read/27086024/a-clinical-trial-comparing-the-safety-and-efficacy-of-topical-tacrolimus-versus-methylprednisolone-in-ocular-graft-versus-host-disease
#18
Tulio B Abud, Francisco Amparo, Ujwala S Saboo, Antonio Di Zazzo, Thomas H Dohlman, Joseph B Ciolino, Pedram Hamrah, Reza Dana
PURPOSE: To evaluate the safety and efficacy of topical tacrolimus 0.05% versus topical methylprednisolone 0.5% in patients with ocular graft-versus-host disease (GVHD). DESIGN: Phase 1/2 prospective, randomized, double-masked clinical trial. PARTICIPANTS: Eighty eyes of 40 patients diagnosed with chronic ocular GVHD were enrolled. METHODS: Forty patients with ocular GVHD were randomized; 24 patients were treated with topical tacrolimus 0...
July 2016: Ophthalmology
https://www.readbyqxmd.com/read/27054516/effect-of-penetrating-keratoplasty-and-keratoprosthesis-implantation-on-the-posterior-segment-of-the-eye
#19
Alja Črnej, Masahiro Omoto, Thomas H Dohlman, Miguel Gonzalez-Andrades, Eleftherios I Paschalis, Andrea Cruzat, T H Khanh Vu, Marianne Doorenbos, Dong Feng Chen, Claes H Dohlman, Reza Dana
PURPOSE: To compare the effects of post-penetrating keratoplasty (PK) and post-keratoprosthesis (KPro) surgery-related inflammation on the posterior segment of the eye and to assess inhibition of tumor necrosis factor alpha (TNFα) and interleukin-1 beta (IL-1β) on these effects. METHODS: BALB/C (syngeneic) or C57BL/6 (allogeneic) corneas were transplanted onto BALB/C host beds as part of PK or miniature KPro (m-KPro) implantation. Intraocular pressure (IOP) was measured via an intracameral pressure sensor; tissues were harvested and analyzed 8 weeks after surgery...
April 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27041871/review-of-scientific-evidence-of-medicinal-convoy-plants-in-traditional-persian-medicine
#20
REVIEW
Seyede Nargess Sadati, Mohammad Reza Shams Ardekani, Nastaran Ebadi, Maryam Yakhchali, Azadeh Raees Dana, Fatemeh Masoomi, Mahnaz Khanavi, Farid Ramezany
One concept used in traditional Persian medicine (TPM) for multidrug therapy is that of the convoy drug (Mobadregh). According to TPM texts, convoy drugs are substances (or drugs), which facilitate the access of drugs or foods to the whole body or to specific organs. This study reviewed some convoy drugs presented in TPM, their biological effects, and their probable interactions with main drugs, considering the increased absorption through inhibition of P-glycoprotein (P-gp) efflux function, bioavailability-enhancing effects, and decreased metabolism of the main drug using electronic databases including PubMed, Scopus, ScienceDirect, and Google Scholar in November and December, 2013...
January 2016: Pharmacognosy Reviews
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