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https://www.readbyqxmd.com/read/29104070/the-role-of-amniotic-membrane-extract-eye-drop-ameed-in-in-vivo-cultivation-of-limbal-stem-cells
#1
Alireza Baradaran-Rafii, Niloufar Shayan Asl, Marzieh Ebrahimi, Sayena Jabbehdari, Shahram Bamdad, Danial Roshandel, Medi Eslani, Maryam Momeni
BACKGROUND: Limbal stem cell transplantation (LSCT) is the definitive treatment for total limbal stem cell deficiency (LSCD). This study evaluates the anatomical and visual outcomes of a surgical technique supplemented by amniotic membrane extract eye drop (AMEED) for in vivo cultivation of limbal stem cells (LSCs). METHODS: One small limbal block (2 × 1 mm) harvested from the contralateral healthy eye was transferred to the diseased eye, which had been already covered by cryopreserved amniotic membrane (N = 20)...
November 2, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28959505/update-on-the-management-of-high-risk-penetrating-keratoplasty
#2
Sayena Jabbehdari, Alireza Baradaran Rafii, Ghasem Yazdanpanah, Pedram Hamrah, Edward J Holland, Ali R Djalilian
PURPOSE OF REVIEW: In this article, we review the indications and latest management of high-risk penetrating keratoplasty. RECENT FINDINGS: Despite the immune-privilege status of the cornea, immune-mediated graft rejection still remains the leading cause of corneal graft failure. This is particularly a problem in the high-risk graft recipients, namely patients with previous graft failure due to rejection and those with inflamed and vascularized corneal beds. A number of strategies including both local and systemic immunosuppression are currently used to increase the success rate of high-risk corneal grafts...
March 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28827194/midterm-outcomes-of-penetrating-keratoplasty-after-cultivated-oral-mucosal-epithelial-transplantation-in-chemical-burn
#3
Alireza Baradaran-Rafii, Siamak Delfazayebaher, Nasser Aghdami, Ehsan Taghiabadi, Shahram Bamdad, Danial Roshandel
PURPOSE: To evaluate the midterm outcomes of penetrating keratoplasty (PKP) after cultivated oral mucosal epithelial transplantation (COMET) in patients with bilateral total limbal stem cell deficiency (LSCD) due to chemical burn. METHODS: In this prospective interventional nonrandomized case series, optical PKP was performed in patients with severe stromal opacity after successful COMET. Main outcome measures were stability of the ocular surface, visual acuity improvement and corneal graft survival...
October 2017: Ocular Surface
https://www.readbyqxmd.com/read/28791056/accuracy-of-different-topographic-instruments-in-calculating-corneal-power-after-myopic-photorefractive-keratectomy
#4
Alireza Baradaran-Rafii, Sahba Fekri, Mohammad Rezaie, Shahram Salehi-Rad, Ali Moradi, Tahmineh Motevasseli, Masumeh Kalantarion
PURPOSE: To compare the corneal power measurements obtained using different topographic instruments after myopic photorefractive keratectomy (PRK). METHODS: Patients with myopia who were candidates for corneal refractive surgery were sequentially included. Pre-PRK and six months post-PRK corneal powers were measured using Javal manual keratometer, Orbscan II, Galilei, Tomey TMS4, and EyeSys 2000 topographers. Measured values were compared with those obtained using the clinical history method (CHM)...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28328814/clinical-outcomes-of-new-toric-trifocal-diffractive-intraocular-lens-in-patients-with-cataract-and-stable-keratoconus-six-months-follow-up
#5
Doroodgar Farideh, Sanginabadi Azad, Niazi Feizollah, Niazi Sana, Alinia Cyrus, Ghoreishi Mohammad, Baradaran-Rafii Alireza
PURPOSE: To evaluate the clinical results of toric trifocal diffractive intraocular lens in eyes with cataract and mild keratoconus. METHODS: Five keratoconus patients (10 eyes) that had bilateral AT LISA 939 implantation were selected and had followed in 3-time horizons of 1, 3, and 6 months. Patients were 46 to 65 years old age, corneal astigmatism of (2.00 D at 6.75 D) and cataract that all of them needed cataract surgery. The distance, intermediate and near visual acuities, defocus curve, ocular aberrations, contrast sensitivity, were measured as effectiveness criteria...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28299009/clinical-practice-guidelines-for-prevention-diagnosis-and-management-of-early-and-delayed-onset-ocular-injuries-due-to-mustard-gas-exposure
#6
Zhale Rajavi, Sare Safi, Mohammad Ali Javadi, Mohammad Reza Jafarinasab, Sepehr Feizi, Mohammadreza Sedighi Moghadam, Khosrow Jadidi, Mahmoud Babaei, Armin Shirvani, Alireza Baradaran-Rafii, Hossein Mohammad-Rabei, Hossein Ziaei, Mohammad Ghassemi-Broumand, Siamak Delfaza Baher, Mostafa Naderi, Mahmoodreza Panahi-Bazaz, Siamak Zarei-Ghanavati, Shahriar Hanjani, Hassan Ghasemi, Ramin Salouti, Mojgan Pakbin, Bahareh Kheiri
PURPOSE: To develop clinical practice guidelines (CPGs) for prevention, diagnosis, treatment and follow-up of ocular injuries caused by exposure to mustard gas. METHODS: The clinical questions were designed by the guideline team. Websites and databases including National Guidelines Clearinghouse, National Institute for Clinical Excellence, Cochrane, and PubMed were searched to find related CPGs and explore possible answers to the clinical questions. Since there were no relevant CPGs in the literature, related articles in Persian and English languages were extracted...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28299003/comparison-between-two-scheimpflug-anterior-segment-analyzers
#7
Alireza Baradaran-Rafii, Tahmineh Motevasseli, Forouzan Yazdizadeh, Farid Karimian, Sahba Fekri, Amir Baradaran-Rafii
PURPOSE: To compare the anterior segment indices measured by two Scheimpflug camera machines; Galilei and Pentacam. METHODS: In this observational case series, the anterior segment indices of myopic healthy subjects seeking for refractive surgery were measured by Pentacam and Galilei on the same day. Analyzed parameters were anterior and posterior best fit spheres (BFS), axial curvature, true corneal power, central corneal thickness (CCT), anterior chamber (AC) depth, AC volume, AC angle, and pupil diameter...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28035498/accelerated-versus-conventional-corneal-collagen-cross-linking-in-patients-with-keratoconus-an-intrapatient-comparative-study
#8
Mohammad Mehdi Sadoughi, Bahram Einollahi, Alireza Baradaran-Rafii, Danial Roshandel, Hamidreza Hasani, Mehrdad Nazeri
PURPOSE: To compare the outcomes of the conventional and accelerated corneal collagen cross-linking (CXL) in patients with bilateral progressive keratoconus (KC). METHODS: Fifteen consecutive patients with bilateral progressive KC were enrolled. In each patient, the fellow eyes were randomly assigned to the conventional CXL (3 mW/cm(2) for 30 min) or accelerated CXL (ACXL) (9 mW/cm(2) for 10 min) groups. Manifest refraction; uncorrected and corrected distant visual acuity; maximum and mean keratometry; corneal hysteresis and corneal resistance factor; endothelial cell density and morphology; central corneal thickness; and wavefront aberrations were measured before and 12 months after the CXL...
December 29, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27650263/current-and-upcoming-therapies-for-ocular-surface-chemical-injuries
#9
REVIEW
Alireza Baradaran-Rafii, Medi Eslani, Zeeshan Haq, Ebrahim Shirzadeh, Michael J Huvard, Ali R Djalilian
Chemical injuries frequently result in vision loss, disfigurement, and challenging ocular surface complications. Acute interventions are directed at decreasing the extent of the injury, suppressing inflammation, and promoting ocular surface re-epithelialization. Chronically, management involves controlling inflammation along with rehabilitation and reconstruction of the ocular surface. Future therapies aimed at inhibiting neovascularization and promoting ocular surface regeneration should provide more effective treatment options for the management of ocular chemical injuries...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27467047/late-acute-rejection-after-allograft-limbal-stem-cell-transplantation-evidence-for-long-term-donor-survival
#10
MULTICENTER STUDY
Medi Eslani, Zeeshan Haq, Asadolah Movahedan, Adam Moss, Alireza Baradaran-Rafii, Gautham Mogilishetty, Edward J Holland, Ali R Djalilian
PURPOSE: To describe the clinical presentation and management of late (>3.0 years) acute graft rejection in keratolimbal allograft (KLAL) recipients. METHODS: This was a multicenter, retrospective observational case series. Six eyes of 6 patients with ocular surface transplant at a mean age of 36.2 years were seen at 3 tertiary referral centers for acute graft rejection between 2007 and 2013. Main outcome measures included strength of systemic immunosuppression (SI) at the time of rejection, time to rejection, and clinical presentation of rejection...
January 2017: Cornea
https://www.readbyqxmd.com/read/27051478/corneal-changes-after-collagen-crosslinking-for-keratoconus-using-dual-scheimpflug-imaging
#11
Mohammad Mehdi Sadoughi, Sepehr Feizi, Siamak Delfazayebaher, Alireza Baradaran-Rafii, Bahram Einollahi, Camelia Shahabi
PURPOSE: To evaluate corneal changes after collagen crosslinking (CXL) therapy for keratoconus (KCN) using the Galilei dual Scheimpflug analyzer. METHODS: This prospective, nonrandomized clinical study included 35 eyes of 32 keratoconus patients who had undergone CXL. The eyes were saturated with riboflavin solution and were subjected for 30 minutes to ultraviolet-A (UV-A) light with irradiance of 3 mW/cm(2). Effectiveness of the treatment was assessed by measuring uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), manifest cylinder/sphere, keratometry, pachymetry, posterior and anterior elevations by the Galilei dual Scheimpflug analyzer...
October 2015: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/26837778/electrospun-mat-with-eyelid-fat-derived-stem-cells-as-a-scaffold-for-ocular-epithelial-regeneration
#12
Daruosh Momenzadeh, Alireza Baradaran-Rafii, Saeed Heidari Keshel, Maryam Ebrahimi, Esmaeil Biazar
The aim of this study was to develop nanofibrous gelatin substrates for eyelid fat stem cell (EFSC) expansion that can serve as a potential alternative substrate to replace human amniotic membrane. Biocompatibility results indicated that all substrates were highly biocompatible, as EFSCs could favorably attach and proliferate on the nanofibrous surfaces. Microscopic figures showed that the EFSC were firmly anchored to the substrates and were able to retain a normal stem cell phenotype. Immunocytochemistry (ICC) and real time-PCR results revealed change in the expression profile of EFSCs grown on nanofibrous substrates when compared to those grown on control in epithelial induction condition...
February 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/26546564/effect-of-photorefractive-keratectomy-on-nystagmus-and-visual-functions-in-myopic-patients-with-infantile-nystagmus-syndrome
#13
Abbas Bagheri, Hamed Abbasi, Mehdi Tavakoli, Alireza Baradaran-Rafii, Abdolreza Shaibanizadeh, Bahareh Kheiri, Shahin Yazdani
PURPOSE: To determine the effect of photorefractive keratectomy (PRK) on involuntary eye movements, visual acuity, and contrast sensitivity in myopic patients with infantile nystagmus syndrome. DESIGN: Prospective interventional case series. METHODS: This study was conducted on patients with infantile nystagmus syndrome and myopia equal to or more than -1 diopter (D), who were referred to our clinic over a 2-year period. Patients older than 18 years of age with a stable refraction for at least 1 year who were good candidates for PRK were included...
February 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/26324020/oriented-nanofibrous-silk-as-a-natural-scaffold-for-ocular-epithelial-regeneration
#14
COMPARATIVE STUDY
Esmaeil Biazar, Alireza Baradaran-Rafii, Saeed Heidari-keshel, Sara Tavakolifard
The aim of this study was to develop nanofibrous silk substrates for limbal stem cell expansion that can serve as a potential alternative substrate to replace human amniotic membrane. The human limbal stem cell was used to evaluate the biocompatibility of substrates (random and oriented nanofibrous mats, and human amniotic membrane) based on their phenotypic profile, viability, proliferation, and attachment ability. Biocompatibility results indicated that all substrates were highly biocompatible, as limbal stem cells could favorably attach and proliferate on the nanofibrous surfaces...
2015: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/26075456/double-ring-sign-to-confirm-correct-orientation-of-donor-lenticules-during-descemet-stripping-automated-endothelial-keratoplasty
#15
Siamak Delfazayebaher, Sepehr Feizi, Mohammad Ali Javadi, Alireza Baradaran-Rafii, Mohammad Mehdi Sadoughi, Amir Faramarzi
PURPOSE: To describe a sign that can confirm the correct position of donor lenticules during Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: In this clinical and laboratory study, DSAEK was performed in 3 eyes with a diagnosis of pseudophakic bullous keratopathy. Additionally, 2 whole globes and 2 precut corneoscleral buttons were procured for the purpose of the laboratory part of the study. After removal of recipient Descemet membrane, the donor graft was inserted into the anterior chamber, unfolded, and attached to the posterior corneal stroma with an air bubble...
August 2015: Cornea
https://www.readbyqxmd.com/read/26005561/single-block-conjunctival-limbal-autograft-for-unilateral-total-limbal-stem-cell-deficiency
#16
Alireza Baradaran-Rafii, Mitra Akbari, Ebrahim Shirzadeh, Majid Shams
No abstract text is available yet for this article.
January 2015: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/25897888/cellular-response-of-limbal-stem-cells-on-polycaprolactone-nanofibrous-scaffolds-for-ocular-epithelial-regeneration
#17
Alireza Baradaran-Rafii, Esmaeil Biazar, Saeed Heidari-keshel
PURPOSE: The aim of this study was to develop nanofibrous polycaprolactone (PCL) substrate for limbal stem cell (LSC) expansion that can serve as a potential alternative substrate to replace human amniotic membrane (AM). MATERIALS AND METHODS: The human limbus stem cell was used to evaluate the biocompatibility of substrates (nanofibrous scaffold and, human AM) based on their phenotypic profile, viability, proliferation and attachment ability. RESULTS: Biocompatibility results indicated that the all substrates were highly biocompatible, as LSCs could favorably attach and proliferate on the nanofibrous surface...
2016: Current Eye Research
https://www.readbyqxmd.com/read/25709766/comparison-of-three-phakic-intraocular-lenses-for-correction-of-myopia
#18
Farid Karimian, Alireza Baradaran-Rafii, Seyed Javad Hashemian, Ali Hashemloo, Mohammad Ebrahim Jafari, Mehdi Yaseri, Elham Ghahari, Shadi Akbarian
PURPOSE: To compare the visual outcomes and complications of three different types of phakic intraocular lenses (PIOLs), for correction of moderate to high myopia. METHODS: We reviewed 112 myopic eyes undergoing PIOL implantation using Artisan (40 eyes), Artiflex (36 eyes), and implantable collamer lens (ICL, 36 eyes). Best corrected visual acuity (BCVA), intraocular pressure (IOP), pachymetry, corneal endothelial cell (CEC) loss, and higher order aberrations (HOA) were compared...
October 2014: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/25105018/the-ocular-surface-chemical-burns
#19
REVIEW
Medi Eslani, Alireza Baradaran-Rafii, Asadolah Movahedan, Ali R Djalilian
Ocular chemical burns are common and serious ocular emergencies that require immediate and intensive evaluation and care. The victims of such incidents are usually young, and therefore loss of vision and disfigurement could dramatically affect their lives. The clinical course can be divided into immediate, acute, early, and late reparative phases. The degree of limbal, corneal, and conjunctival involvement at the time of injury is critically associated with prognosis. The treatment starts with simple but vision saving steps and is continued with complicated surgical procedures later in the course of the disease...
2014: Journal of Ophthalmology
https://www.readbyqxmd.com/read/24982736/optical-correction-of-aphakia-in-children
#20
REVIEW
Alireza Baradaran-Rafii, Ebrahim Shirzadeh, Medi Eslani, Mitra Akbari
There are several reasons for which the correction of aphakia differs between children and adults. First, a child's eye is still growing during the first few years of life and during early childhood, the refractive elements of the eye undergo radical changes. Second, the immature visual system in young children puts them at risk of developing amblyopia if visual input is defocused or unequal between the two eyes. Third, the incidence of many complications, in which certain risks are acceptable in adults, is unacceptable in children...
January 2014: Journal of Ophthalmic & Vision Research
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