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https://www.readbyqxmd.com/read/27650263/current-and-upcoming-therapies-for-ocular-surface-chemical-injuries
#1
Alireza Baradaran-Rafii, Medi Eslani, Zeeshan Haq, Ebrahim Shirzadeh, Michael J Huvard, Ali R Djalilian
Chemical injuries frequently result in vision loss, disfigurement, and challenging ocular surface complications. Acute interventions are directed at decreasing the extent of the injury, suppressing inflammation, and promoting ocular surface re-epithelialization. Chronically, management involves controlling inflammation along with rehabilitation and reconstruction of the ocular surface. Future therapies aimed at inhibiting neovascularization and promoting ocular surface regeneration should provide more effective treatment options for the management of ocular chemical injuries...
September 17, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27467047/late-acute-rejection-after-allograft-limbal-stem-cell-transplantation-evidence-for-long-term-donor-survival
#2
Medi Eslani, Zeeshan Haq, Asadolah Movahedan, Adam Moss, Alireza Baradaran-Rafii, Gautham Mogilishetty, Edward J Holland, Ali R Djalilian
PURPOSE: To describe the clinical presentation and management of late (>3.0 years) acute graft rejection in keratolimbal allograft (KLAL) recipients. METHODS: This was a multicenter, retrospective observational case series. Six eyes of 6 patients with ocular surface transplant at a mean age of 36.2 years were seen at 3 tertiary referral centers for acute graft rejection between 2007 and 2013. Main outcome measures included strength of systemic immunosuppression (SI) at the time of rejection, time to rejection, and clinical presentation of rejection...
July 27, 2016: Cornea
https://www.readbyqxmd.com/read/27051478/corneal-changes-after-collagen-crosslinking-for-keratoconus-using-dual-scheimpflug-imaging
#3
Mohammad Mehdi Sadoughi, Sepehr Feizi, Siamak Delfazayebaher, Alireza Baradaran-Rafii, Bahram Einollahi, Camelia Shahabi
PURPOSE: To evaluate corneal changes after collagen crosslinking (CXL) therapy for keratoconus (KCN) using the Galilei dual Scheimpflug analyzer. METHODS: This prospective, nonrandomized clinical study included 35 eyes of 32 keratoconus patients who had undergone CXL. The eyes were saturated with riboflavin solution and were subjected for 30 minutes to ultraviolet-A (UV-A) light with irradiance of 3 mW/cm(2). Effectiveness of the treatment was assessed by measuring uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), manifest cylinder/sphere, keratometry, pachymetry, posterior and anterior elevations by the Galilei dual Scheimpflug analyzer...
October 2015: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/26837778/electrospun-mat-with-eyelid-fat-derived-stem-cells-as-a-scaffold-for-ocular-epithelial-regeneration
#4
Daruosh Momenzadeh, Alireza Baradaran-Rafii, Saeed Heidari Keshel, Maryam Ebrahimi, Esmaeil Biazar
The aim of this study was to develop nanofibrous gelatin substrates for eyelid fat stem cell (EFSC) expansion that can serve as a potential alternative substrate to replace human amniotic membrane. Biocompatibility results indicated that all substrates were highly biocompatible, as EFSCs could favorably attach and proliferate on the nanofibrous surfaces. Microscopic figures showed that the EFSC were firmly anchored to the substrates and were able to retain a normal stem cell phenotype. Immunocytochemistry (ICC) and real time-PCR results revealed change in the expression profile of EFSCs grown on nanofibrous substrates when compared to those grown on control in epithelial induction condition...
February 2, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/26546564/effect-of-photorefractive-keratectomy-on-nystagmus-and-visual-functions-in-myopic-patients-with-infantile-nystagmus-syndrome
#5
Abbas Bagheri, Hamed Abbasi, Mehdi Tavakoli, Alireza Baradaran-Rafii, Abdolreza Shaibanizadeh, Bahareh Kheiri, Shahin Yazdani
PURPOSE: To determine the effect of photorefractive keratectomy (PRK) on involuntary eye movements, visual acuity, and contrast sensitivity in myopic patients with infantile nystagmus syndrome. DESIGN: Prospective interventional case series. METHODS: This study was conducted on patients with infantile nystagmus syndrome and myopia equal to or more thanĀ -1 diopter (D), who were referred to our clinic over a 2-year period. Patients older than 18 years of age with a stable refraction for at least 1 year who were good candidates for PRK were included...
February 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/26324020/oriented-nanofibrous-silk-as-a-natural-scaffold-for-ocular-epithelial-regeneration
#6
COMPARATIVE STUDY
Esmaeil Biazar, Alireza Baradaran-Rafii, Saeed Heidari-keshel, Sara Tavakolifard
The aim of this study was to develop nanofibrous silk substrates for limbal stem cell expansion that can serve as a potential alternative substrate to replace human amniotic membrane. The human limbal stem cell was used to evaluate the biocompatibility of substrates (random and oriented nanofibrous mats, and human amniotic membrane) based on their phenotypic profile, viability, proliferation, and attachment ability. Biocompatibility results indicated that all substrates were highly biocompatible, as limbal stem cells could favorably attach and proliferate on the nanofibrous surfaces...
2015: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/26075456/double-ring-sign-to-confirm-correct-orientation-of-donor-lenticules-during-descemet-stripping-automated-endothelial-keratoplasty
#7
Siamak Delfazayebaher, Sepehr Feizi, Mohammad Ali Javadi, Alireza Baradaran-Rafii, Mohammad Mehdi Sadoughi, Amir Faramarzi
PURPOSE: To describe a sign that can confirm the correct position of donor lenticules during Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: In this clinical and laboratory study, DSAEK was performed in 3 eyes with a diagnosis of pseudophakic bullous keratopathy. Additionally, 2 whole globes and 2 precut corneoscleral buttons were procured for the purpose of the laboratory part of the study. After removal of recipient Descemet membrane, the donor graft was inserted into the anterior chamber, unfolded, and attached to the posterior corneal stroma with an air bubble...
August 2015: Cornea
https://www.readbyqxmd.com/read/26005561/single-block-conjunctival-limbal-autograft-for-unilateral-total-limbal-stem-cell-deficiency
#8
Alireza Baradaran-Rafii, Mitra Akbari, Ebrahim Shirzadeh, Majid Shams
No abstract text is available yet for this article.
January 2015: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/25897888/cellular-response-of-limbal-stem-cells-on-polycaprolactone-nanofibrous-scaffolds-for-ocular-epithelial-regeneration
#9
Alireza Baradaran-Rafii, Esmaeil Biazar, Saeed Heidari-keshel
PURPOSE: The aim of this study was to develop nanofibrous polycaprolactone (PCL) substrate for limbal stem cell (LSC) expansion that can serve as a potential alternative substrate to replace human amniotic membrane (AM). MATERIALS AND METHODS: The human limbus stem cell was used to evaluate the biocompatibility of substrates (nanofibrous scaffold and, human AM) based on their phenotypic profile, viability, proliferation and attachment ability. RESULTS: Biocompatibility results indicated that the all substrates were highly biocompatible, as LSCs could favorably attach and proliferate on the nanofibrous surface...
2016: Current Eye Research
https://www.readbyqxmd.com/read/25709766/comparison-of-three-phakic-intraocular-lenses-for-correction-of-myopia
#10
Farid Karimian, Alireza Baradaran-Rafii, Seyed Javad Hashemian, Ali Hashemloo, Mohammad Ebrahim Jafari, Mehdi Yaseri, Elham Ghahari, Shadi Akbarian
PURPOSE: To compare the visual outcomes and complications of three different types of phakic intraocular lenses (PIOLs), for correction of moderate to high myopia. METHODS: We reviewed 112 myopic eyes undergoing PIOL implantation using Artisan (40 eyes), Artiflex (36 eyes), and implantable collamer lens (ICL, 36 eyes). Best corrected visual acuity (BCVA), intraocular pressure (IOP), pachymetry, corneal endothelial cell (CEC) loss, and higher order aberrations (HOA) were compared...
October 2014: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/25105018/the-ocular-surface-chemical-burns
#11
REVIEW
Medi Eslani, Alireza Baradaran-Rafii, Asadolah Movahedan, Ali R Djalilian
Ocular chemical burns are common and serious ocular emergencies that require immediate and intensive evaluation and care. The victims of such incidents are usually young, and therefore loss of vision and disfigurement could dramatically affect their lives. The clinical course can be divided into immediate, acute, early, and late reparative phases. The degree of limbal, corneal, and conjunctival involvement at the time of injury is critically associated with prognosis. The treatment starts with simple but vision saving steps and is continued with complicated surgical procedures later in the course of the disease...
2014: Journal of Ophthalmology
https://www.readbyqxmd.com/read/24982736/optical-correction-of-aphakia-in-children
#12
REVIEW
Alireza Baradaran-Rafii, Ebrahim Shirzadeh, Medi Eslani, Mitra Akbari
There are several reasons for which the correction of aphakia differs between children and adults. First, a child's eye is still growing during the first few years of life and during early childhood, the refractive elements of the eye undergo radical changes. Second, the immature visual system in young children puts them at risk of developing amblyopia if visual input is defocused or unequal between the two eyes. Third, the incidence of many complications, in which certain risks are acceptable in adults, is unacceptable in children...
January 2014: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/24682177/different-techniques-for-performing-dalk-are-they-making-a-real-difference
#13
EDITORIAL
Alireza Baradaran-Rafii, Hamidreza Hasani
No abstract text is available yet for this article.
October 2014: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/24653828/mustard-gas-induced-ocular-surface-disorders
#14
Alireza Baradaran-Rafii, Mohammad-Ali Javadi, Farid Karimian, Sepehr Feizi
No abstract text is available yet for this article.
October 2013: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/24162750/limbal-stem-cell-sparing-lamellar-keratoplasty-for-the-management-of-advanced-keratoglobus
#15
Farid Karimian, Alireza Baradaran-Rafii, Amir Faramarzi, Mitra Akbari
PURPOSE: To describe the technique and outcomes of limbal stem cell-sparing lamellar keratoplasty (LSCS-LKP) for the management of advanced keratoglobus (KGB). METHODS: In a sequential interventional case series from March 2010 to December 2012, 8 eyes of 6 patients with advanced KGB underwent an LSCS-LKP. Three patients had isolated KGB, 2 were affected with the Ehlers-Danlos syndrome, and the other subject had osteogenesis imperfecta. Epithelial healing, anatomical results (corneal thickness and keratometry), and visual outcomes were evaluated after this intervention...
January 2014: Cornea
https://www.readbyqxmd.com/read/23137665/femtosecond-laser-assisted-corneal-transplantation
#16
EDITORIAL
Alireza Baradaran-Rafii, Medi Eslani
No abstract text is available yet for this article.
June 2013: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/23095908/bacterial-contamination-of-amniotic-membrane-in-a-tissue-bank-from-iran
#17
Hamid Reza Aghayan, Parisa Goodarzi, Alireza Baradaran-Rafii, Bagher Larijani, Leila Moradabadi, Fakher Rahim, Babak Arjmand
Human Amniotic Membrane (AM) transplantation can promote tissue healing and reduce inflammation, tissue scarring and neovascularization. Homa Peyvand Tamin (HPT) tissue bank has focused on manufacturing human cell and tissue based products including AM. The purpose of this study is to evaluate and identify bacterial contamination of AMs that is produced by HPT for several ophthalmic applications. From July 2006 to April 2011, 122 placentas from cesarean sections were retrieved by HPT after obtaining informed consent from the donors...
September 2013: Cell and Tissue Banking
https://www.readbyqxmd.com/read/23084124/anwar-versus-melles-deep-anterior-lamellar-keratoplasty-for-keratoconus-a-prospective-randomized-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Alireza Baradaran-Rafii, Medi Eslani, Mohammad-Mehdi Sadoughi, Hamed Esfandiari, Farid Karimian
PURPOSE: To compare the outcomes of 2 techniques (Anwar vs. Melles) of deep anterior lamellar keratoplasty (DALK) in patients with keratoconus. DESIGN: Randomized, double-blind clinical trial. PARTICIPANTS: Fifty-seven eyes of 57 patients 20 to 35 years of age were enrolled. METHODS: Patients with clinical diagnosis of keratoconus who were contact lens intolerant and whose corrected distance visual acuity (CDVA) was less than 20/80 were enrolled...
February 2013: Ophthalmology
https://www.readbyqxmd.com/read/23073489/complications-of-keratolimbal-allograft-surgery
#19
Alireza Baradaran-Rafii, Medi Eslani, Ali R Djalillian
PURPOSE: To report postoperative complications of keratolimbal allograft (KLAL) transplantation in patients with bilateral total limbal stem cell deficiency. METHODS: In this retrospective observational case series, medical charts of 45 patients with at least 6 months of follow-up were reviewed. The main outcome measure was postoperative complications including graft-related issues (thickness, position, and alignment) and immunologic rejection. RESULTS: Sixty-six KLALs were performed on 45 eyes...
May 2013: Cornea
https://www.readbyqxmd.com/read/22784272/cultivated-limbal-and-oral-mucosal-epithelial-transplantation
#20
Medi Eslani, Alireza Baradaran-Rafii, Sajjad Ahmad
Stem cells located at the limbus are the ultimate source for regeneration of the corneal epithelium in normal and traumatized states. When limbal stem cells are dysfunctional or deficient, limbal stem cell deficiency (LSCD) develops. Its surgical management depends on laterality and severity of corneal-limbal involvement. Conventional methods of stem cell transplantation are conjunctival-limbal autograft (CLAU), conjunctival-limbal allograft (CLAL), and kerato-limbal allograft (KLAL) surgeries. Cultivated limbal epithelial transplantation (CLET) and cultivated oral mucosal epithelial transplantation (COMET) on a carrier such as amniotic membrane are current surgical alternatives...
May 2012: Seminars in Ophthalmology
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