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https://www.readbyqxmd.com/read/24908203/medically-reversible-limbal-stem-cell-disease-clinical-features-and-management-strategies
#1
Bryan Y Kim, Kamran M Riaz, Pejman Bakhtiari, Clara C Chan, Jeffrey D Welder, Edward J Holland, Surendra Basti, Ali R Djalilian
PURPOSE: To describe the clinical features and management strategies in patients whose limbal stem cell (LSC) disease reversed with medical therapy. DESIGN: Retrospective case series. PARTICIPANTS: Twenty-two eyes of 15 patients seen at 3 tertiary referral centers between 2007 and 2011 with 3 months or more of follow-up. METHODS: Medical records of patients with medically reversible LSC disease were reviewed. Demographic data, causes, location and duration of disease, and medical inventions were analyzed...
October 2014: Ophthalmology
https://www.readbyqxmd.com/read/24113371/corneal-keloid-report-of-natural-history-and-outcome-of-surgical-management-in-two-cases
#2
Pejman Bakhtiari, Daniel R Agarwal, Ana Alzaga Fernandez, Tatyana Milman, Ben Glasgow, Christopher E Starr, Anthony J Aldave
PURPOSE: To report the natural history and the outcome after the surgical management of 2 cases of corneal keloids. METHODS: Two male patients, 21 and 24 years old, with a history of corneal opacity for 5 and 17 years, respectively, with no history of an ocular trauma were studied. RESULTS: The first patient initially underwent a superficial keratectomy (SK), after which the corneal opacification recurred. He subsequently underwent 2 SK procedures combined with phototherapeutic keratectomy and mitomycin C, followed by a femtosecond laser-assisted deep anterior lamellar keratoplasty...
December 2013: Cornea
https://www.readbyqxmd.com/read/23580847/presentation-diagnosis-and-management-of-limbal-stem-cell-deficiency
#3
REVIEW
Kunjal Sejpal, Pejman Bakhtiari, Sophie X Deng
The human corneal surface epithelium is continuously repopulated by the limbal stem cells (LSCs). Limbal Stem Cell Deficiency (LSCD) can lead to corneal opacity and vascularization, with consequent visual impairment or blindness. Many acquired and congenital diseases can lead to LCSD by direct injury to the LSCs, destruction of LSC niche, or both. Based on the severity of the disease, LSCD can present with various symptoms and signs. Although LSCD can be detected clinically, laboratory tests are necessary to confirm the diagnosis and monitor the disease progression...
January 2013: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/23559851/exclusion-of-pathogenic-promoter-region-variants-and-identification-of-novel-nonsense-mutations-in-the-zinc-finger-e-box-binding-homeobox-1-gene-in-posterior-polymorphous-corneal-dystrophy
#4
Pejman Bakhtiari, Ricardo F Frausto, Ashley N Roldan, Cynthia Wang, Fei Yu, Anthony J Aldave
PURPOSE: To report the identification of five novel nonsense mutations in the zinc finger E-box binding homeobox 1 (ZEB1) gene and exclusion of promoter region mutations in individuals without ZEB1 coding region mutations in posterior polymorphous corneal dystrophy (PPCD). METHODS: Slit-lamp examination and DNA collection were performed for individuals diagnosed with PPCD and, when available, affected and unaffected family members. Genomic DNA prepared from peripheral blood leukocytes and buccal epithelial cells underwent PCR amplification and automated sequencing of the ZEB1 gene and 1 kb 5' of ZEB1, presumably containing the ZEB1 promoter region...
2013: Molecular Vision
https://www.readbyqxmd.com/read/23479529/correlation-between-retinal-nerve-fiber-layer-thickness-by-optical-coherence-tomography-and-perimetric-parameters-in-optic-atrophy
#5
Mostafa Soltan-Sanjari, Mohammad-Mehdi Parvaresh, Arash Maleki, Khalil Ghasemi-Falavarjani, Pejman Bakhtiari
PURPOSE: To investigate the correlation between retinal nerve fiber layer (RNFL) thickness determined by optical coherence tomography (OCT) and visual field (VF) parameters in patients with optic atrophy. METHODS: This study was performed on 35 eyes of 28 patients with optic atrophy. RNFL thickness was measured by OCT (Carl Zeiss, Jena, Germany) and automated perimetry was performed using the Humphrey Field Analyzer (Carl Zeiss, Jena, Germany). The correlation between RNFL thickness and VF parameters was evaluated...
April 2008: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/23470591/the-international-use-of-the-boston-type-i-keratoprosthesis
#6
REVIEW
Michelle J Kim, Pejman Bakhtiari, Anthony J Aldave
No abstract text is available yet for this article.
2013: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/22606467/limbitis-secondary-to-autologous-serum-eye-drops-in-a-patient-with-atopic-keratoconjunctivitis
#7
Jeffrey David Welder, Pejman Bakhtiari, Ali R Djalilian
Purpose. Report a case of limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. Design. Interventional case report. Methods. A 32-year-old African American female with atopic keratoconjunctivitis (AKC) presented with chronic dry eye and diffuse punctate epithelial erosions refractory to conservative treatment. She was initially managed with cyclosporine ophthalmic 0.05% in addition to preservative-free artificial tears and olopatadine hydrochloride 0.2% for 6 months...
2011: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/22265154/surgical-and-visual-outcomes-of-the-type-i-boston-keratoprosthesis-for-the-management-of-aniridic-fibrosis-syndrome-in-congenital-aniridia
#8
Pejman Bakhtiari, Clara Chan, Jeffrey D Welder, Jose de la Cruz, Edward J Holland, Ali R Djalilian
PURPOSE: To report the clinical features and surgical management of aniridic fibrosis syndrome using the type I Boston Keratoprosthesis (KPro). DESIGN: Interventional case series. METHODS: Retrospective chart review of 9 eyes in 9 patients with congenital aniridia that developed aniridic fibrosis syndrome. RESULTS: All patients had clinical diagnosis of congenital aniridia. Previously, all patients had undergone cataract surgery with posterior chamber intraocular lens (IOL) implantation and 7 patients had existing tube shunts...
May 2012: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/20802316/perilimbal-bevacizumab-injection-for-interface-neovascularization-after-deep-anterior-lamellar-keratoplasty
#9
Alireza Foroutan, Beigzadeh Fariba, Bakhtiari Pejman, Joshaghani Mahmoud, Ghasemi Falavarjani Khalil, Ehteshami Afshar Arash, Pooria Foroutan
PURPOSE: To evaluate the effect of perilimbal bevacizumab injection on neovascularization at the interface of donor and recipient tissues after deep anterior lamellar keratoplasty (DALK). METHODS: This interventional case series included 4 patients with interface neovascularization after DALK (3 patients with advanced keratoconus and 1 patient with scarring because of herpetic keratitis). Bevacizumab (2.5 mg/0.1 mL) was injected subconjunctivally near the limbus adjacent to the abnormal blood vessels...
November 2010: Cornea
https://www.readbyqxmd.com/read/20543931/update-on-limbal-stem-cell-transplantation
#10
Pejman Bakhtiari, Ali Djalilian
Limbal epithelial stem cells are the primary source of corneal epithelial cell regeneration. Limbal stem cell deficiency (LSCD) can develop in traumatic, immunologic, or genetic diseases that affect the ocular surface. LSCD leads to conjunctivalization, with corneal vascularization and opacification and subsequent loss of vision. Limbal stem cell transplantation is a surgical treatment to address LSCD and restore a corneal epithelial phenotype. Based on the source of cells, limbal transplant can be autologous or allogenic...
January 2010: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/20299977/midterm-outcomes-of-autologous-cultivated-limbal-stem-cell-transplantation-with-or-without-penetrating-keratoplasty
#11
COMPARATIVE STUDY
Alireza Baradaran-Rafii, Marzieh Ebrahimi, Mozhgan Rezaei Kanavi, Ehsan Taghi-Abadi, Nasser Aghdami, Medi Eslani, Pejman Bakhtiari, Bahram Einollahi, Hossein Baharvand, Mohammad-Ali Javadi
PURPOSE: To report the midterm outcomes of autologous limbal stem cell transplantation cultivated on amniotic membrane (AM) with or without subsequent penetrating keratoplasty (PKP) in patients with total unilateral limbal stem cell deficiency (LSCD). METHODS: Eight eyes of 8 consecutive patients with unilateral total LSCD underwent autologous limbal stem cell transplantation cultivated on AM. Four eyes underwent subsequent optical PKP. Main outcome measures were corneal vascularization and transparency...
May 2010: Cornea
https://www.readbyqxmd.com/read/19779730/cryotherapy-of-sclerotomy-sites-for-prevention-of-late-post-vitrectomy-diabetic-hemorrhage-a-randomized-clinical-trial
#12
RANDOMIZED CONTROLLED TRIAL
Morteza Entezari, Alireza Ramezani, Hamid Ahmadieh, Pejman Bakhtiari, Mehdi Yaseri, Kian Soltani
BACKGROUND: To evaluate the role of cryotherapy of sclerotomy sites in prevention of late (after 4 weeks) post-vitrectomy diabetic hemorrhage. METHODS: In a prospective randomized double-masked clinical trial, a total of 124 eyes of 119 patients underwent pars plana vitrectomy for complications of proliferative diabetic retinopathy. At the end of vitrectomy, the eyes were randomly assigned to two groups. The case group received two cryotherapy spots at each sclerotomy site, whereas the eyes in the control group received no further intervention...
January 2010: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/18362558/emla-cream-application-without-occlusive-dressing-before-upper-facial-botulinum-toxin-injection-a-randomized-double-blind-placebo-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Mohsen Bahmani Kashkouli, Shabnam Salimi, Pejman Bakhtiari, Mohammad Mehdi Parvaresh, Mostafa Soltan Sanjari, Masood Naseripour
A randomized, double-blind, placebo-controlled clinical trial was conducted among 44 subjects to assess the efficacy of EMLA cream application without occlusive dressing on pain on needling (PN) and pain on injection (PI) felt during multiple botulinum toxin type A (BTA) injections for correction of hyperkinetic upper facial lines. Mean PN score was less than PI score with high correlation and no significant difference. Although both PN and PI scores (visual analog) were less in the EMLA than placebo group, the difference was only statistically significant for PN score...
April 2008: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/17416325/cataract-surgery-for-congenital-cataract-endothelial-cell-characteristics-corneal-thickness-and-impact-on-intraocular-pressure
#14
Naveed Nilforushan, Khalil Ghasemi Falavarjani, Mohammad Reza Razeghinejad, Pejman Bakhtiari
PURPOSE: To investigate whether central corneal thickness (CCT), endothelial cell characteristics, and intraocular pressure (IOP) are affected in patients with previous congenital cataract surgery and to focus on their clinical significance. METHODS: CCT and IOP measurements and specular microscopy were performed in 31 eyes of 17 cases of extracted congenital cataracts and 40 eyes of 20 age- and sex-matched participants as control group. The mean of three pachymetry measurements of the central cornea was taken as CCT...
April 2007: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/17189802/pupil-dilation-with-intracameral-lidocaine-during-phacoemulsification
#15
COMPARATIVE STUDY
Aminollah Nikeghbali, Khalil Ghasemi Falavarjani, Ahmad Kheirkhah, Pejman Bakhtiari, Mohsen Bahmani Kashkouli
PURPOSE: To evaluate pupil dilation by an intracameral injection of nonpreserved lidocaine 1% during phacoemulsification cataract extraction and compare the results with those using conventional topical mydriatics. SETTING: Department of Ophthalmology, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. METHODS: A prospective comparative case series study was conducted. The study included 57 patients who were given topical mydriatics (30 eyes) or intracameral lidocaine (27 eyes) to dilate the pupil for phacoemulsification and intraocular lens implantation...
January 2007: Journal of Cataract and Refractive Surgery
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