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https://www.readbyqxmd.com/read/27911382/a-simple-mechanical-procedure-to-create-limbal-stem-cell-deficiency-in-mouse
#1
Neda Afsharkhamseh, Elham Ghahari, Medi Eslani, Ali R Djalilian
Limbal stem cell deficiency (LSCD) is a state of malfunction or loss of limbal epithelial stem cells, after which the corneal epithelium is replaced with conjunctiva. Patients suffer from recurrent corneal defects, pain, inflammation, and loss of vision. Previously, a murine model of LSCD was described and compared to two other models. The goal was to produce a consistent mouse model of LSCD that both mimics the phenotype in humans and lasts long enough to make it possible to study the disease pathophysiology and to evaluate new treatments...
November 17, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27650263/current-and-upcoming-therapies-for-ocular-surface-chemical-injuries
#2
Alireza Baradaran-Rafii, Medi Eslani, Zeeshan Haq, Ebrahim Shirzadeh, Michael J Huvard, Ali R Djalilian
Chemical injuries frequently result in vision loss, disfigurement, and challenging ocular surface complications. Acute interventions are directed at decreasing the extent of the injury, suppressing inflammation, and promoting ocular surface re-epithelialization. Chronically, management involves controlling inflammation along with rehabilitation and reconstruction of the ocular surface. Future therapies aimed at inhibiting neovascularization and promoting ocular surface regeneration should provide more effective treatment options for the management of ocular chemical injuries...
September 17, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27467047/late-acute-rejection-after-allograft-limbal-stem-cell-transplantation-evidence-for-long-term-donor-survival
#3
Medi Eslani, Zeeshan Haq, Asadolah Movahedan, Adam Moss, Alireza Baradaran-Rafii, Gautham Mogilishetty, Edward J Holland, Ali R Djalilian
PURPOSE: To describe the clinical presentation and management of late (>3.0 years) acute graft rejection in keratolimbal allograft (KLAL) recipients. METHODS: This was a multicenter, retrospective observational case series. Six eyes of 6 patients with ocular surface transplant at a mean age of 36.2 years were seen at 3 tertiary referral centers for acute graft rejection between 2007 and 2013. Main outcome measures included strength of systemic immunosuppression (SI) at the time of rejection, time to rejection, and clinical presentation of rejection...
January 2017: Cornea
https://www.readbyqxmd.com/read/26607808/stability-of-limbal-stem-cell-deficiency-after-mechanical-and-thermal-injuries-in-mice
#4
Neda Afsharkhamseh, Asadolah Movahedan, Sanaz Gidfar, Michael Huvard, Lisa Wasielewski, Behrad Y Milani, Medi Eslani, Ali R Djalilian
We studied the reproducibility and stability of limbal stem cell deficiency (LSCD) in mice following controlled injuries to the corneal and limbal epithelia. In one method, corneal and limbal epithelia were entirely removed with a 0.5 mm metal burr. In the other, limbus to limbus epithelial removal with the burr was followed by thermal injury to the limbus. These two methods were compared with a previously published one. Unwounded corneas were used as control. The corneas were examined monthly for three months by slit lamp with fluorescein staining...
April 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/25709771/intravitreal-bevacizumab-injection-alone-or-combined-with-triamcinolone-versus-macular-photocoagulation-in-bilateral-diabetic-macular-edema-application-of-bivariate-generalized-linear-mixed-model-with-asymmetric-random-effects-in-a-subgroup-of-a-clinical-trial
#5
Mehdi Yaseri, Hojjat Zeraati, Kazem Mohammad, Masoud Soheilian, Alireza Ramezani, Medi Eslani, Gholam A Peyman
PURPOSE: To compare the efficacy of intravitreal bevacizumab (IVB) injection alone or with intravitreal triamcinolone acetonide (IVB/IVT) versus macular photocoagulation (MPC) in bilateral diabetic macular edema (DME). METHODS: In this study we revisited data from a subset of subjects previously enrolled in a randomized clinical trial. The original study included 150 eyes randomized to three treatment arms: 1.25 mg IVB alone, combined injection of 1.25 mg IVB and 2 mg IVT, and focal or modified grid MPC...
October 2014: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/25183764/the-role-of-toll-like-receptor-4-in-corneal-epithelial-wound-healing
#6
Medi Eslani, Asadolah Movahedan, Neda Afsharkhamseh, Herve Sroussi, Ali R Djalilian
PURPOSE: We evaluated the role of Toll-like receptor 4 (TLR4) in corneal epithelial wound healing. METHODS: The expression of TLR4 during in vivo corneal epithelial wound healing was examined by immunostaining in mice. The expression and activation of TLR4 was studied in primary or telomerase-immortalized human corneal epithelial cells (HCEC). Scratch assay was performed to evaluate in vitro wound closure using live time-lapse microscopy. Transwell migration assay and Ki67 immunostaining were done to evaluate migration and proliferation, respectively...
September 2014: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/25105018/the-ocular-surface-chemical-burns
#7
REVIEW
Medi Eslani, Alireza Baradaran-Rafii, Asadolah Movahedan, Ali R Djalilian
Ocular chemical burns are common and serious ocular emergencies that require immediate and intensive evaluation and care. The victims of such incidents are usually young, and therefore loss of vision and disfigurement could dramatically affect their lives. The clinical course can be divided into immediate, acute, early, and late reparative phases. The degree of limbal, corneal, and conjunctival involvement at the time of injury is critically associated with prognosis. The treatment starts with simple but vision saving steps and is continued with complicated surgical procedures later in the course of the disease...
2014: Journal of Ophthalmology
https://www.readbyqxmd.com/read/24982736/optical-correction-of-aphakia-in-children
#8
REVIEW
Alireza Baradaran-Rafii, Ebrahim Shirzadeh, Medi Eslani, Mitra Akbari
There are several reasons for which the correction of aphakia differs between children and adults. First, a child's eye is still growing during the first few years of life and during early childhood, the refractive elements of the eye undergo radical changes. Second, the immature visual system in young children puts them at risk of developing amblyopia if visual input is defocused or unequal between the two eyes. Third, the incidence of many complications, in which certain risks are acceptable in adults, is unacceptable in children...
January 2014: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/24653823/ocular-graft-versus-host-disease-following-allogeneic-stem-cell-transplantation-a-review-of-current-knowledge-and-recommendations
#9
REVIEW
Nariman Nassiri, Medi Eslani, Nekoo Panahi, Shiva Mehravaran, Alireza Ziaei, Ali R Djalilian
Graft versus host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). Ocular GVHD develops in approximately 40-60% of patients following allo-SCT and its most common clinical manifestations include keratoconjunctivitis sicca and cicatricial conjunctivitis. Ocular GVHD may lead to severe ocular surface disease, which can significantly diminish quality of life and restrict daily activities. It is thus important to monitor the condition closely since with timely diagnosis, irreversible damage can be avoided...
October 2013: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/23183351/short-time-mitomycin-c-application-during-photorefractive-keratectomy-in-patients-with-low-myopia
#10
RANDOMIZED CONTROLLED TRIAL
Ahmad Shojaei, Mohsen Ramezanzadeh, Saeed Soleyman-Jahi, Mina Almasi-Nasrabadi, Parisa Rezazadeh, Medi Eslani
PURPOSE: To evaluate the safety and efficacy of 5 seconds of mitomycin-C (MMC) application during photorefractive keratectomy (PRK) for low myopia. SETTING: Basir Eye Clinic, Tehran, Iran. DESIGN: Prospective randomized sham-controlled double-masked clinical trial. METHODS: Patients with low myopia and an ablation depth of less than 65 μm were recruited. One eye of each patient was included in the study and was randomly assigned to receive intraoperative topical MMC 0...
February 2013: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/23137665/femtosecond-laser-assisted-corneal-transplantation
#11
EDITORIAL
Alireza Baradaran-Rafii, Medi Eslani
No abstract text is available yet for this article.
June 2013: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/23084124/anwar-versus-melles-deep-anterior-lamellar-keratoplasty-for-keratoconus-a-prospective-randomized-clinical-trial
#12
RANDOMIZED CONTROLLED TRIAL
Alireza Baradaran-Rafii, Medi Eslani, Mohammad-Mehdi Sadoughi, Hamed Esfandiari, Farid Karimian
PURPOSE: To compare the outcomes of 2 techniques (Anwar vs. Melles) of deep anterior lamellar keratoplasty (DALK) in patients with keratoconus. DESIGN: Randomized, double-blind clinical trial. PARTICIPANTS: Fifty-seven eyes of 57 patients 20 to 35 years of age were enrolled. METHODS: Patients with clinical diagnosis of keratoconus who were contact lens intolerant and whose corrected distance visual acuity (CDVA) was less than 20/80 were enrolled...
February 2013: Ophthalmology
https://www.readbyqxmd.com/read/23073489/complications-of-keratolimbal-allograft-surgery
#13
Alireza Baradaran-Rafii, Medi Eslani, Ali R Djalillian
PURPOSE: To report postoperative complications of keratolimbal allograft (KLAL) transplantation in patients with bilateral total limbal stem cell deficiency. METHODS: In this retrospective observational case series, medical charts of 45 patients with at least 6 months of follow-up were reviewed. The main outcome measure was postoperative complications including graft-related issues (thickness, position, and alignment) and immunologic rejection. RESULTS: Sixty-six KLALs were performed on 45 eyes...
May 2013: Cornea
https://www.readbyqxmd.com/read/22935601/effect-of-timolol-on-refractive-outcomes-in-eyes-with-myopic-regression-after-laser-in-situ-keratomileusis-a-prospective-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Ahmad Shojaei, Medi Eslani, Yasaman Vali, Mohammad Mansouri, Nima Dadman, Mehdi Yaseri
PURPOSE: To compare the effects of timolol on refractive outcomes in eyes with myopic regression after laser in situ keratomileusis (LASIK) with a control-matched group. DESIGN: Prospective, randomized, parallel-controlled, double-masked clinical trial. A computer-generated randomization list based on random block permutation (length 4 to 8) was used for treatment allocation. METHODS: setting: Basir Eye Center, Tehran, Iran. PATIENT POPULATION: Of 124 eyes with myopic regression after LASIK using Technolas 217-Z, 45 eyes in each group were analyzed...
November 2012: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/22784272/cultivated-limbal-and-oral-mucosal-epithelial-transplantation
#15
Medi Eslani, Alireza Baradaran-Rafii, Sajjad Ahmad
Stem cells located at the limbus are the ultimate source for regeneration of the corneal epithelium in normal and traumatized states. When limbal stem cells are dysfunctional or deficient, limbal stem cell deficiency (LSCD) develops. Its surgical management depends on laterality and severity of corneal-limbal involvement. Conventional methods of stem cell transplantation are conjunctival-limbal autograft (CLAU), conjunctival-limbal allograft (CLAL), and kerato-limbal allograft (KLAL) surgeries. Cultivated limbal epithelial transplantation (CLET) and cultivated oral mucosal epithelial transplantation (COMET) on a carrier such as amniotic membrane are current surgical alternatives...
May 2012: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/22236787/postoperative-complications-of-conjunctival-limbal-autograft-surgery
#16
Alireza Baradaran-Rafii, Medi Eslani, Hossein Jamali, Farid Karimian, Urvi A Tailor, Ali R Djalilian
PURPOSE: To report postoperative complications of conjunctival limbal autograft in patients with unilateral total limbal stem cell deficiency (LSCD). METHODS: In this retrospective observational case series, medical charts of 34 patients with unilateral total LSCD with at least 6 months of follow-up were reviewed. Main outcome measure was postoperative complications. RESULTS: The mean follow-up period was 17.2 ± 6.3 (range, 6-33) months. The postoperative complications observed included conjunctival encroachment over the graft, small graft, graft dislodging, thick graft, improper position, graft edema, ocular surface exposure, progressive horizontal conjunctivalization, and pyogenic granuloma...
August 2012: Cornea
https://www.readbyqxmd.com/read/21877678/mechanical-versus-alcohol-assisted-epithelial-debridement-during-photorefractive-keratectomy-a-confocal-microscopic-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Bahram Einollahi, Alireza Baradaran-Rafii, Mozhgan Rezaei-Kanavi, Medi Eslani, Mohammad-Reza Parchegani, Mohammad Zare, Sepehr Feizi, Farid Karimian
PURPOSE: To compare the effects of mechanical versus alcohol-assisted epithelial debridement on corneal cellular elements after photorefractive keratectomy (PRK) using confocal microscopy. METHODS: This randomized, clinical trial included 66 eyes from 33 patients with spherical equivalent refraction <-4.00 diopters (D). Mechanical versus alcohol-assisted epithelial debridement was performed during PRK. The right eye of each patient was randomly assigned to one group (mechanical group or alcohol-assisted group) and the fellow eye to the alternate group...
December 2011: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/21791191/sulfur-mustard-induced-ocular-surface-disorders
#18
REVIEW
Alireza Baradaran-Rafii, Medi Eslani, Scheffer C G Tseng
Sulfur mustard is a vesicant agent with severe irritating effects on living tissues, including skin, mucous membranes, eyes, and respiratory tract. The eyes are the most susceptible tissue to mustard gas effects, and varying degrees of ocular involvement are seen in 75% to 90% of exposed individuals. Most cases resolve uneventfully; however, a minority of exposed patients will have a continuous process, which manifests clinically either as a persistent smoldering inflammation (chronic form) or late-onset lesions appearing many years after a variable "silent" period (delayed form)...
July 2011: Ocular Surface
https://www.readbyqxmd.com/read/20871473/accommodative-changes-after-photorefractive-keratectomy-in-myopic-eyes
#19
COMPARATIVE STUDY
Farid Karimian, Alireza Baradaran-Rafii, Abbas Bagheri, Medi Eslani, Homa Bayat, Shila Aramesh, Mehdi Yaseri, Anahita Amin-Shokravi
PURPOSE: To determine the changes of amplitude of accommodation (AA) and facility of accommodation (FA) in myopic patients after photorefractive keratectomy (PRK). METHODS: Using Technolas 217Z excimer laser, 160 myopic eyes of 80 patients underwent PRK. The patients were categorized into two age groups: <30 and ≥30 years. Changes in AA and FA were observed before PRK and at 2 weeks, 1 month, and 3 months after PRK. The role of preoperative AA, FA, refractive spherical equivalent, age, and sex on postoperative AA and FA was evaluated...
November 2010: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/20856106/deep-anterior-lamellar-keratoplasty-for-maroteaux-lamy-syndrome
#20
Mohsen Rahmati-Kamel, Mohammadali Javadi, Ahmad Shojaei, Medi Eslani, Farid Karimian
PURPOSE: To present a case of Maroteaux-Lamy syndrome (MLS), which underwent deep anterior lamellar keratoplasty (DALK) for visual rehabilitation. METHODS: A 15-year-old girl with MLS was admitted with severe corneal opacity. We performed DALK on her left eye for visual rehabilitation. Big-bubble technique was used to perform lamellar separation. RESULTS: Corneal graft was clear 24 months after surgery. Best spectacle-corrected visual acuity of left eye was 20/25 with the correction of +0...
December 2010: Cornea
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