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https://www.readbyqxmd.com/read/28467885/diving-and-pulmonary-physiology-surfactant-binding-protein-lung-fluid-and-cardiopulmonary-test-changes-in-professional-divers
#1
Zora Susilovic-Grabovac, Cristina Banfi, Denise Brusoni, Massimo Mapelli, Stefania Ghilardi, Ante Obad, Darija Bakovic-Kramaric, Zeljko Dujic, Piergiuseppe Agostoni
Alteration of breathing pattern ranging from an increase of respiratory rate to overt hyperventilation during and after SCUBA diving is frequently reported and is associated with intrathoracic fluid overload. This study was undertaken to assess breathing efficiency after diving and the association with damage of alveolar cells. Ventilation efficiency (VE/VCO2) during maximal cardiopulmonary exercise test (CPET) before and 2h after a standard protocol dive has been analyzed in twelve professional males divers (39...
April 30, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28465192/lung-inflammation-and-genotoxicity-in-mice-lungs-after-pulmonary-exposure-to-candle-light-combustion-particles
#2
Astrid Skovmand, Ana Cecilia Damiao Gouveia, Ismo Kalevi Koponen, Peter Møller, Steffen Loft, Martin Roursgaard
Candle burning produces a large amount of particles that contribute substantially to the exposure to indoor particulate matter. The exposures to various types of combustion particles, such as diesel exhaust particles, have been associated with increased risk of lung cancer by mechanisms that involve oxidative stress, inflammation and genotoxicity. The aim of this study was to compare pulmonary effects of candle light combustion particles (CP) with two benchmark diesel exhaust particles (A-DEP and SRM2975). Intratracheal (i...
April 29, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28392888/cerium-oxide-nanoparticles-in-lung-acutely-induce-oxidative-stress-inflammation-and-dna-damage-in-various-organs-of-mice
#3
Abderrahim Nemmar, Priya Yuvaraju, Sumaya Beegam, Mohamed A Fahim, Badreldin H Ali
CeO2 nanoparticles (CeO2 NPs) which are used as a diesel fuel additive are emitted in the particulate phase in the exhaust, posing a health concern. However, limited information exists regarding the in vivo acute toxicity of CeO2 NPs on multiple organs. Presently, we investigated the acute (24 h) effects of intratracheally instilled CeO2 NPs in mice (0.5 mg/kg) on oxidative stress, inflammation, and DNA damage in major organs including lung, heart, liver, kidneys, spleen, and brain. Lipid peroxidation measured by malondialdehyde production was increased in the lungs only, and reactive oxygen species were increased in the lung, heart, kidney, and brain...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28359838/graphene-oxide-nanosheets-induced-genotoxicity-and-pulmonary-injury-in-mice
#4
Nabil A El-Yamany, Faten F Mohamed, Taher A Salaheldin, Amany A Tohamy, Walaa N Abd El-Mohsen, Adel S Amin
Graphene and graphene-related materials have broadly applied in biomedical purposes due to their unique properties, thus safety evaluation of them is crucial. This study was performed to explore the genotoxic and pulmonary toxic potential of different doses of graphene oxide nanosheets' (GOs) in mice.A total of 90 male mature mice were randomly divided into six groups of fifteen mice per each, five groups were intraperitoneally injected by GO at doses of 10, 50, 100, 250 and 500μg/kg b.w once weekly in addition to the control group that was injected intraperitoneally with 0...
March 27, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28245934/the-chemical-composition-of-ultrafine-particles-and-associated-biological-effects-at-an-alpine-town-impacted-by-wood-burning
#5
Emanuela Corsini, Roberta Vecchi, Laura Marabini, Paola Fermo, Silvia Becagli, Vera Bernardoni, Donatella Caruso, Lorenza Corbella, Manuela Dell'Acqua, Corrado L Galli, Giovanni Lonati, Senem Ozgen, Angela Papale, Stefano Signorini, Ruggero Tardivo, Gianluigi Valli, Marina Marinovich
This work is part of the TOBICUP (TOxicity of BIomass Combustion generated Ultrafine Particles) project which aimed at providing the composition of ultrafine particles (UFPs, i.e. particles with aerodynamic diameter, dae, lower than 100nm) emitted by wood combustion and elucidating the related toxicity. Results here reported are from two ambient monitoring campaigns carried out at an alpine town in Northern Italy, where wood burning is largely diffused for domestic heating in winter. Wintertime and summertime UFP samples were analyzed to assess their chemical composition (i...
February 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28157391/microbes-associate-with-host-innate-immune-response-in-idiopathic-pulmonary-fibrosis
#6
Yong Huang, Shwu-Fan Ma, Milena S Espindola, Rekha Vij, Justin M Oldham, Gary B Huffnagle, John R Erb-Downward, Kevin R Flaherty, Beth B Moore, Eric S White, Tong Zhou, Jianrong Li, Yves A Lussier, MeiLan K Han, Naftali Kaminski, Joe G N Garcia, Cory M Hogaboam, Fernando J Martinez, Imre Noth
RATIONALE: Differences in the lung microbial community influence idiopathic pulmonary fibrosis (IPF) progression. Whether the lung microbiome influences IPF host defense remains unknown. OBJECTIVES: To explore the host immune response and microbial interaction in IPF, as they relate to progression-free survival (PFS), fibroblast function, and leukocyte phenotypes. METHODS: Paired microarray gene expression data from peripheral blood mononuclear cells (PBMCs) and 16s rRNA sequencing data from bronchoalveolar lavage (BAL) obtained as part of the COMET-IPF study were used to conduct association pathway analyses...
February 3, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28138562/amphetamines-promote-mitochondrial-dysfunction-and-dna-damage-in-pulmonary-hypertension
#7
Pin-I Chen, Aiqin Cao, Kazuya Miyagawa, Nancy F Tojais, Jan K Hennigs, Caiyun G Li, Nathaly M Sweeney, Audrey S Inglis, Lingli Wang, Dan Li, Matthew Ye, Brian J Feldman, Marlene Rabinovitch
Amphetamine (AMPH) or methamphetamine (METH) abuse can cause oxidative damage and is a risk factor for diseases including pulmonary arterial hypertension (PAH). Pulmonary artery endothelial cells (PAECs) from AMPH-associated-PAH patients show DNA damage as judged by γH2AX foci and DNA comet tails. We therefore hypothesized that AMPH induces DNA damage and vascular pathology by interfering with normal adaptation to an environmental perturbation causing oxidative stress. Consistent with this, we found that AMPH alone does not cause DNA damage in normoxic PAECs, but greatly amplifies DNA damage in hypoxic PAECs...
January 26, 2017: JCI Insight
https://www.readbyqxmd.com/read/28018592/dna-damage-and-repair-capacity-in-lymphocyte-of-chronic-obstructive-pulmonary-diseases-patients-during-physical-exercise-with-oxygen-supplementation
#8
Andréa Lúcia Gonçalves da Silva, Thaís Evelyn Karnopp, Augusto Ferreira Weber, Cassia da Luz Goulart, Paloma de Borba Scheneiders, Dannuey Machado Cardoso, Lisiane Lisboa Carvalho, Joel Henrique Ellwanger, Lia Gonçalves Possuelo, Andréia Rosane de Moura Valim
BACKGROUND: We hypothesized that the use of oxygen supplementation during aerobic exercise induces less DNA damage than exercise alone. The aim of this study is to assess the level of DNA damage induced by physical exercise with and without oxygen supplementation in chronic obstructive pulmonary diseases (COPD) patients. METHODS: Peripheral blood was collected before and after aerobic exercise in two conditions: (I) aerobic exercise without oxygen supplementation (AE group) and (II) with oxygen supplementation (AE-O2 group)...
2016: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28011748/genotoxicity-and-gene-expression-analyses-of-liver-and-lung-tissues-of-mice-treated-with-titanium-dioxide-nanoparticles
#9
Yan Li, Jian Yan, Wei Ding, Ying Chen, Lindsay M Pack, Tao Chen
Titanium dioxide nanoparticles (TiO2 NPs) are used in paints, plastics, papers, inks, foods, toothpaste, pharmaceuticals and cosmetics. However, TiO2 NPs cause inflammation, pulmonary damage, fibrosis and lung tumours in animals and are possibly carcinogenic to humans. Although there are a large number of studies on the toxicities of TiO2 NPs, the data are inconclusive and the mechanisms underlying the toxicity are not clear. In this study, we used the Comet assay to evaluate genotoxicity and whole-genome microarray technology to analyse gene expression pattern in vivo to explore the possible mechanisms for toxicity and genotoxicity of TiO2 NPs...
January 2017: Mutagenesis
https://www.readbyqxmd.com/read/27894680/frequency-of-micronuclei-and-other-biomarkers-of-dna-damage-in-populations-exposed-to-dusts-asbestos-and-other-fibers-a-systematic-review
#10
REVIEW
Stefano Bonassi, Mirta Milić, Monica Neri
Airborne particles are small, solid particles projected into the air either by natural forces, or by mechanical or man-made processes, and include fibers and dusts. Their toxicity is usually subsequent to inhalation and can lead to pulmonary dysfunctions and diseases, including cancer. Cytochalasin B blocked micronucleus assay in lymphocytes (L-CBMN) has been shown as a sensitive and reliable technique in assessing genotoxic exposure, An extensive search of the PubMed and Web of Science databases allowed retrieval of 18 articles on occupational or environmental exposure evaluating L-CBMN in subjects exposed to fibers or dusts (asbestos, silica, rockwool, beryllium, tobacco, and wood)...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27771415/structural-transition-of-kidney-cystatin-induced-by-silicon-dioxide-nanoparticles-an-implication-for-renal-diseases
#11
Anas Shamsi, Azaj Ahmed, Bilqees Bano
Nanotechnology is one of the fastest growing fields of science owing to use of nanomaterials in industries and medicine across the globe. Currently silicon dioxide nanoparticles (SiO2 NPs) are one of the most popular nanomaterials owing to their inert toxicity profile and hence exposure to SiO2 nanoparticles is on the increase. Cystatins are thiol proteinase inhibitors (TPIs) ubiquitously distributed in plants and animals and they are now at the heed of a number of normal and pathological conditions and shouldn't be regarded solely as TPIs...
January 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27764219/study-on-the-cytotoxic-genotoxic-and-clastogenic-potential-of-attalea-phalerata-mart-ex-spreng-oil-pulp-in-vitro-and-in-vivo-experimental-models
#12
Fernando Freitas de Lima, Sara Emilia Lima Tolouei Menegati, Giseli Karenina Traesel, Flávio Henrique Souza de Araújo, Caroline Honaiser Lescano, Sara Moraes Peixoto, Felipe Ariel Mao Silva, Silvia Cristina Heredia Vieira, Maria do Carmo Vieira, Silvia Aparecida Oesterreich
Attalea phalerata Mart. ex Spreng. (Arecaceae), popularly known as "bacuri", is used in Brazilian folk medicine. Its oil is used orally to relieve pulmonary congestion and joint pain. In topical applications, it is applied as an effective hair tonic and anti-dandruff. The in natura pulp and its nuts are used as food because of its nutritional value. Despite its use in folk medicine, there is a lack of data regarding its in vivo/in vitro cytotoxic/genotoxic and clastogenic effects. Therefore, in this study, we evaluated the cytotoxic, genotoxic and clastogenic effects of Attalea phalerata Mart...
2016: PloS One
https://www.readbyqxmd.com/read/27680806/e5-lung-ultrasound-and-echocardiography-for-peripartum-haemodynamic-monitoring-of-patients-with-severe-preeclampsia
#13
J Ambrozic, K Prokselj, M Lucovnik
INTRODUCTION: The ability to judge intravascular volume is fundamental in the management of patients with severe preeclampsia. Insufficient intravascular volume can result in decreased oxygen delivery to tissues and exacerbates organ dysfunction. On the other hand, fluid excesses can lead to fluid extravasation and pulmonary edema. Outside of pregnancy, transthoracic echocardiography and lung ultrasonography have become important diagnostic and monitoring tools in critically ill patients...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27660304/crackles-and-comets-lung-ultrasound-to-detect-pulmonary-congestion-in-patients-on-dialysis-is-coming-of-age
#14
EDITORIAL
Richard A Sherman
No abstract text is available yet for this article.
November 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27658823/surface-modification-does-not-influence-the-genotoxic-and-inflammatory-effects-of-tio2-nanoparticles-after-pulmonary-exposure-by-instillation-in-mice
#15
Håkan Wallin, Zdenka O Kyjovska, Sarah S Poulsen, Nicklas R Jacobsen, Anne T Saber, Stefan Bengtson, Petra Jackson, Ulla Vogel
The influence of surface charge of nanomaterials on toxicological effects is not yet fully understood. We investigated the inflammatory response, the acute phase response and the genotoxic effect of two different titanium dioxide nanoparticles (TiO2 NPs) following a single intratracheal instillation. NRCWE-001 was unmodified rutile TiO2 with endogenous negative surface charge, whereas NRCWE-002 was surface modified to be positively charged. C57BL/6J BomTac mice received 18, 54 and 162 µg/mouse and were humanely killed 1, 3 and 28 days post-exposure...
January 2017: Mutagenesis
https://www.readbyqxmd.com/read/27633763/distribution-quantification-and-toxicity-of-cinnamaldehyde-in-electronic-cigarette-refill-fluids-and-aerosols
#16
Rachel Z Behar, Wentai Luo, Sabrina C Lin, Yuhuan Wang, Jackelyn Valle, James F Pankow, Prue Talbot
OBJECTIVE: The aim of this study was to evaluate the distribution, concentration and toxicity of cinnamaldehyde in electronic cigarette (e-cigarette) refill fluids and aerosols. METHODS: The distribution and concentration of cinnamaldehyde were determined in 39 e-cigarette refill fluids plus 6 duplicates using gas chromatography and mass spectrometry (GC/MS). A cinnamaldehyde toxicity profile was established for embryonic and adult cells using a live cell imaging assay, immunocytochemistry, the comet assay and a recovery assay...
November 2016: Tobacco Control
https://www.readbyqxmd.com/read/27402482/toxic-and-dna-damaging-effects-of-a-functionalized-fullerene-in-human-embryonic-lung-fibroblasts
#17
E S Ershova, V A Sergeeva, A I Chausheva, D G Zheglo, V A Nikitina, T D Smirnova, L V Kameneva, L N Porokhovnik, S I Kutsev, P A Troshin, I I Voronov, E A Khakina, N N Veiko, S V Kostyuk
Water-soluble fullerenes have been studied as potential nanovectors and therapeutic agents, but their possible toxicity is of concern. We have studied the effects of F-828, a soluble fullerene [C60] derivative, on diploid human embryonic lung fibroblasts (HELFs) in vitro. F-828 causes complex time-dependent changes in ROS levels. Inhibition of Nox4 activity by plumbagin blocks F-828-dependent ROS elevation. F-828 induces DNA breaks, as measured by the comet assay and γH2AX expression, and the activities of the transcription factors NF-kB and p53 increase...
July 2016: Mutation Research. Genetic Toxicology and Environmental Mutagenesis
https://www.readbyqxmd.com/read/27323801/airway-irritation-inflammation-and-toxicity-in-mice-following-inhalation-of-metal-oxide-nanoparticles
#18
Søren T Larsen, Petra Jackson, Steen S Poulsen, Marcus Levin, Keld A Jensen, Håkan Wallin, Gunnar D Nielsen, Ismo K Koponen
Metal oxide nanoparticles are used in a broad range of industrial processes and workers may be exposed to aerosols of the particles both during production and handling. Despite the widespread use of these particles, relatively few studies have been performed to investigate the toxicological effects in the airways following inhalation. In the present study, the acute (24 h) and persistent (13 weeks) effects in the airways after a single exposure to metal oxide nanoparticles were studied using a murine inhalation model...
November 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27174289/ultrasound-of-extravascular-lung-water-a-new-standard-for-pulmonary-congestion
#19
REVIEW
Eugenio Picano, Patricia A Pellikka
Extravascular lung water (EVLW) is a key variable in heart failure management and prognosis, but its objective assessment remains elusive. Lung imaging has been traditionally considered off-limits for ultrasound techniques due to the acoustic barrier of high-impedance air wall. In pulmonary congestion however, the presence of both air and water creates a peculiar echo fingerprint. Lung ultrasound shows B-lines, comet-like signals arising from a hyper-echoic pleural line with a to-and-fro movement synchronized with respiration...
July 14, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27139168/clinical-manifestations-and-long-term-outcome-of-anti-jo1-antisynthetase-patients-in-a-large-cohort-of-spanish-patients-from-the-geas-iim-group
#20
Ernesto Trallero-Araguás, Josep María Grau-Junyent, Anne Labirua-Iturburu, Francisco José García-Hernández, Manuel Monteagudo-Jiménez, Guadalupe Fraile-Rodriguez, Iñigo Les-Bujanda, Mónica Rodriguez-Carballeira, Luis Sáez-Comet, Albert Selva-O'Callaghan
OBJECTIVE: To evaluate the clinical manifestations, long-term clinical outcome and longitudinal pulmonary function in a large cohort of Spanish patients with anti-Jo1 antibodies. METHODS: We retrospectively analyzed the clinical data and lung function parameters of 148 anti-Jo1 patients recruited from a multicentre registry including 18 Spanish hospitals. A composite endpoint was defined, comprising death due to respiratory failure directly related to antisynthetase syndrome (ASS), the need for long-term oxygen therapy or lung transplantation...
October 2016: Seminars in Arthritis and Rheumatism
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