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Ali r djalilian

Ali R Djalilian
No abstract text is available yet for this article.
April 2016: Journal of Cataract and Refractive Surgery
Alireza Baradaran-Rafii, Medi Eslani, Zeeshan Haq, Ebrahim Shirzadeh, Michael J Huvard, Ali R Djalilian
Chemical injuries frequently result in vision loss, disfigurement, and challenging ocular surface complications. Acute interventions are directed at decreasing the extent of the injury, suppressing inflammation, and promoting ocular surface re-epithelialization. Chronically, management involves controlling inflammation along with rehabilitation and reconstruction of the ocular surface. Future therapies aimed at inhibiting neovascularization and promoting ocular surface regeneration should provide more effective treatment options for the management of ocular chemical injuries...
September 17, 2016: Ocular Surface
Medi Eslani, Zeeshan Haq, Asadolah Movahedan, Adam Moss, Alireza Baradaran-Rafii, Gautham Mogilishetty, Edward J Holland, Ali R Djalilian
PURPOSE: To describe the clinical presentation and management of late (>3.0 years) acute graft rejection in keratolimbal allograft (KLAL) recipients. METHODS: This was a multicenter, retrospective observational case series. Six eyes of 6 patients with ocular surface transplant at a mean age of 36.2 years were seen at 3 tertiary referral centers for acute graft rejection between 2007 and 2013. Main outcome measures included strength of systemic immunosuppression (SI) at the time of rejection, time to rejection, and clinical presentation of rejection...
July 27, 2016: Cornea
Navid Ghassembaglou, Ali R Djalilian
No abstract text is available yet for this article.
January 2016: Journal of Ophthalmic & Vision Research
Kavitha R Sivaraman, Renu V Jivrajka, Ketki Soin, Charles S Bouchard, Asadolah Movahedan, Ellen Shorter, Sandeep Jain, Deborah S Jacobs, Ali R Djalilian
PURPOSE: Describe the presentation and management of superior limbic keratoconjunctivitis (SLK)-like inflammation and secondary limbal stem cell dysfunction in the setting of ocular chronic graft-versus-host disease (cGVHD). METHODS: Retrospective observational case series in a multicenter clinical practice. Participants were 13 patients (26 eyes) with ocular cGVHD and SLK-like inflammation presenting to the University of Illinois at Chicago and BostonSight® between January 1, 2009 and July 1, 2013...
July 2016: Ocular Surface
Sanaz Gidfar, Neda Afsharkhamseh, Sara Sanjari, Ali R Djalilian
PURPOSE: Notch1 was previously shown to play a critical role in murine meibomian gland function and maintenance. In this study, we have examined the expression and activation of Notch pathway in human meibomian gland epithelial cells in vitro. METHODS: An immortalized human meibomian gland epithelial cell (HMGEC) line was cultured under proliferative and differentiative conditions. Expression of Notch receptors and ligands were evaluated by quantitative PCR and Western blot...
March 2016: Investigative Ophthalmology & Visual Science
Neda Afsharkhamseh, Asadolah Movahedan, Sanaz Gidfar, Michael Huvard, Lisa Wasielewski, Behrad Y Milani, Medi Eslani, Ali R Djalilian
We studied the reproducibility and stability of limbal stem cell deficiency (LSCD) in mice following controlled injuries to the corneal and limbal epithelia. In one method, corneal and limbal epithelia were entirely removed with a 0.5 mm metal burr. In the other, limbus to limbus epithelial removal with the burr was followed by thermal injury to the limbus. These two methods were compared with a previously published one. Unwounded corneas were used as control. The corneas were examined monthly for three months by slit lamp with fluorescein staining...
April 2016: Experimental Eye Research
Satvik R Hadigal, Alex M Agelidis, Ghadah A Karasneh, Thessicar E Antoine, Abraam M Yakoub, Vishnu C Ramani, Ali R Djalilian, Ralph D Sanderson, Deepak Shukla
Herpesviruses exemplified by herpes simplex virus-1 (HSV-1) attach to cell surface heparan sulfate (HS) for entry into host cells. However, during a productive infection, the HS moieties on parent cells can trap newly exiting viral progenies and inhibit their release. Here we demonstrate that a HS-degrading enzyme of the host, heparanase (HPSE), is upregulated through NF-kB and translocated to the cell surface upon HSV-1 infection for the removal of HS to facilitate viral release. We also find a significant increase in HPSE release in vivo during infection of murine corneas and that knockdown of HPSE in vivo inhibits virus shedding...
2015: Nature Communications
Neda Afsharkhamseh, Asadolah Movahedan, Hooman Motahari, Ali R Djalilian
In this article we review essentials of diagnosis and management of ocular surface disease in patients who undergo cataract surgery. It is clearly shown that dry eye disease worsens following the cataract surgery in patients with prior history of ocular surface disease, Also new cases of dry eye might appear. Current strategies for the timely diagnosis and proper management of dry eye syndrome in the face of cataract surgery patients are mainly emphasized. To achieve the best outcome in cataract surgery, a healthy ocular surface is crucial...
July 2014: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Medi Eslani, Asadolah Movahedan, Neda Afsharkhamseh, Herve Sroussi, Ali R Djalilian
PURPOSE: We evaluated the role of Toll-like receptor 4 (TLR4) in corneal epithelial wound healing. METHODS: The expression of TLR4 during in vivo corneal epithelial wound healing was examined by immunostaining in mice. The expression and activation of TLR4 was studied in primary or telomerase-immortalized human corneal epithelial cells (HCEC). Scratch assay was performed to evaluate in vitro wound closure using live time-lapse microscopy. Transwell migration assay and Ki67 immunostaining were done to evaluate migration and proliferation, respectively...
September 2014: Investigative Ophthalmology & Visual Science
Medi Eslani, Alireza Baradaran-Rafii, Asadolah Movahedan, Ali R Djalilian
Ocular chemical burns are common and serious ocular emergencies that require immediate and intensive evaluation and care. The victims of such incidents are usually young, and therefore loss of vision and disfigurement could dramatically affect their lives. The clinical course can be divided into immediate, acute, early, and late reparative phases. The degree of limbal, corneal, and conjunctival involvement at the time of injury is critically associated with prognosis. The treatment starts with simple but vision saving steps and is continued with complicated surgical procedures later in the course of the disease...
2014: Journal of Ophthalmology
Bryan Y Kim, Kamran M Riaz, Pejman Bakhtiari, Clara C Chan, Jeffrey D Welder, Edward J Holland, Surendra Basti, Ali R Djalilian
PURPOSE: To describe the clinical features and management strategies in patients whose limbal stem cell (LSC) disease reversed with medical therapy. DESIGN: Retrospective case series. PARTICIPANTS: Twenty-two eyes of 15 patients seen at 3 tertiary referral centers between 2007 and 2011 with 3 months or more of follow-up. METHODS: Medical records of patients with medically reversible LSC disease were reviewed. Demographic data, causes, location and duration of disease, and medical inventions were analyzed...
October 2014: Ophthalmology
Nariman Nassiri, Medi Eslani, Nekoo Panahi, Shiva Mehravaran, Alireza Ziaei, Ali R Djalilian
Graft versus host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). Ocular GVHD develops in approximately 40-60% of patients following allo-SCT and its most common clinical manifestations include keratoconjunctivitis sicca and cicatricial conjunctivitis. Ocular GVHD may lead to severe ocular surface disease, which can significantly diminish quality of life and restrict daily activities. It is thus important to monitor the condition closely since with timely diagnosis, irreversible damage can be avoided...
October 2013: Journal of Ophthalmic & Vision Research
Ahmad A Aref, Kavitha R Sivaraman, Ali R Djalilian
Glaucoma may develop or worsen after ocular surface transplantation and often requires surgical management for adequate intraocular pressure control. Traditional glaucoma filtering procedures in patients with prior ocular surface transplant may be problematic for several reasons, which include mechanical disruption of the pre-existing graft, epithelial and stem cell toxicity induced by antifibrotic agents, and increased risk of future corneal transplantation failure. We describe the implantation of a glaucoma drainage implant via a limbal-based conjunctival incision with tube placement in the ciliary sulcus in three eyes of two patients with prior ocular surface transplantation...
May 2015: Seminars in Ophthalmology
Behrad Y Milani, Farnoud Y Milani, Dong-Wouk Park, Abed Namavari, Jarna Shah, Hossein Amirjamshidi, Hongyu Ying, Ali R Djalilian
PURPOSE: Corneal stromal scarring partly involves the production of corneal myofibroblasts. The purpose of this study was to examine the effects of rapamycin (an inhibitor of the mammalian target of rapamycin [mTOR] pathway) on myofibroblast formation in vitro and in-vivo. METHODS: Human corneal fibroblasts were grown in culture and transformed into myofibroblasts using TGF-β (2 ng/mL). The phosphorylation (activation) of the mTOR pathway was examined by immunoblotting...
November 2013: Investigative Ophthalmology & Visual Science
Asadolah Movahedan, Neda Afsharkhamseh, Hossein M Sagha, Jarna R Shah, Behrad Y Milani, Farnoud Y Milani, Hercules D Logothetis, Chi-Chao Chan, Ali R Djalilian
The corneal epithelium is the outermost layer of the cornea that directly faces the outside environment, hence it plays a critical barrier function. Previously, conditional loss of Notch1 on the ocular surface was found to cause inflammation and keratinization of the corneal epithelium. This was in part attributed to impaired vitamin A metabolism, loss of the meibomian glands and recurrent eyelid trauma. We hypothesized that Notch1 plays an essential role in the corneal epithelial barrier function and is a contributing factor in the pathologic changes in these mice...
2013: PloS One
Edward C Wu, Shawn Zardouz, Hossein Mahboubi, Ali K Ashtiani, Shawhin Shahriari, Kasra Ziai, Vanessa S Rothholtz, Hamid R Djalilian
No abstract text is available yet for this article.
June 2013: Otology & Neurotology
Behrad Y Milani, Mercede Majdi, Wesley Green, Amir Mehralian, Majid Moarefi, Freddie S Oh, Janet M Riddle, Ali R Djalilian
OBJECTIVE: To use a novel teaching exercise to encourage students to practice ophthalmoscopy and to measure the learning effect both subjectively and objectively. DESIGN: Comparative case series. PARTICIPANTS: One hundred thirty-one fourth-year medical students on their 1-week ophthalmology rotations with 89 in the experimental group and 42 in the control group. METHODS: Those in the experimental group had 1 eye dilated and their optic nerve photographed on the first day...
April 2013: Ophthalmology
Nariman Nassiri, Ali R Djalilian
No abstract text is available yet for this article.
January 2009: Journal of Ophthalmic & Vision Research
Asadolah Movahedan, Mercede Majdi, Neda Afsharkhamseh, Hossein M Sagha, Niloufar S Saadat, Keivan Shalileh, Behrad Y Milani, Hongyu Ying, Ali R Djalilian
PURPOSE: To determine the role of Notch signaling in corneal epithelial migration and wound healing. METHODS: Immunolocalization of Notch1 was performed during epithelial wound healing in vivo in mouse corneal epithelial debridement wounds and in vitro in primary human corneal epithelial cells following a linear scratch wound. The effects of Notch inhibition, using the γ-secretase inhibitor N-(N-[3,5-difluorophenacetyl]-l-alanyl)-S-phenylglycine t-butyl ester (DAPT) or following stable transfection with Notch1-short hairpin RNA (shRNA), was evaluated in a scratch assay and transwell migration assay...
November 2012: Investigative Ophthalmology & Visual Science
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