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https://www.readbyqxmd.com/read/28959505/update-on-the-management-of-high-risk-penetrating-keratoplasty
#1
Sayena Jabbehdari, Alireza Baradaran Rafii, Ghasem Yazdanpanah, Pedram Hamrah, Edward J Holland, Ali R Djalilian
PURPOSE OF REVIEW: In this article, we review the indications and latest management of high-risk penetrating keratoplasty. RECENT FINDINGS: Despite the immune-privilege status of the cornea, immune-mediated graft rejection still remains the leading cause of corneal graft failure. This is particularly a problem in the high-risk graft recipients, namely patients with previous graft failure due to rejection and those with inflamed and vascularized corneal beds. A number of strategies including both local and systemic immunosuppression are currently used to increase the success rate of high-risk corneal grafts...
March 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/28817391/tacrolimus-eye-drops-as-adjunct-therapy-in-severe-corneal-endothelial-rejection-refractory-to-corticosteroids
#2
Reza Ghaffari, Hamed Ghassemi, Mehran Zarei-Ghanavati, Golshan Latifi, Shima Dehghani, Zeeshan Haq, Ali R Djalilian
PURPOSE: To evaluate the safety and efficacy of tacrolimus eye drops as adjunctive therapy in the treatment of severe corneal endothelial rejection after penetrating keratoplasty refractory to corticosteroids. METHODS: In this prospective interventional case series, 11 eyes of 11 patients assessed for severe corneal endothelial rejection, with an inadequate response to topical, local, and systemic corticosteroids, were treated with either 0.01% or 0.05% tacrolimus eye drops 4 times daily...
October 2017: Cornea
https://www.readbyqxmd.com/read/28582374/management-of-corneal-scarring-secondary-to-herpes-zoster-keratitis
#3
Omar M Hassan, Asim V Farooq, Ketki Soin, Ali R Djalilian, Joshua H Hou
PURPOSE: To review the management of visually significant corneal scarring secondary to herpes zoster keratitis (HZK). METHODS: Literature review. RESULTS: Management options for visually significant corneal scarring secondary to HZK include scleral contact lenses, photorefractive or phototherapeutic keratectomy, lamellar keratoplasty, penetrating keratoplasty, and keratoprosthesis. Many authors recommend tarsorrhaphy in at-risk patients at the time of corneal transplantation...
August 2017: Cornea
https://www.readbyqxmd.com/read/28399066/limbal-and-corneal-epithelial-homeostasis
#4
REVIEW
Ghasem Yazdanpanah, Sayena Jabbehdari, Ali R Djalilian
PURPOSE OF REVIEW: The aim of this review is to describe the underlying mechanisms of corneal epithelial homeostasis in addition to illustrating the vital role of the limbal epithelial stem cells (LESCs) and the limbal niche in epithelial regeneration and wound healing. RECENT FINDINGS: The shedded corneal epithelial cells are constantly replenished by the LESCs which give rise to epithelial cells that proliferate, differentiate, and migrate centripetally. While some recent studies have proposed that epithelial stem cells may also be present in the central cornea, the predominant location for the stem cells is the limbus...
July 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28054657/rapamycin-prolongs-the-survival-of-corneal-epithelial-cells-in-culture
#5
Sanaz Gidfar, Farnoud Y Milani, Behrad Y Milani, Xiang Shen, Medi Eslani, Ilham Putra, Michael J Huvard, Hossein Sagha, Ali R Djalilian
Rapamycin has previously been shown to have anti-aging effects in cells and organisms. These studies were undertaken to investigate the effects of rapamycin on primary human corneal epithelial cells in vitro. Cell growth and viability were evaluated by bright field microscopy. Cell proliferation and cycle were evaluated by flow cytometry. The expression of differentiation markers was evaluated by quantitative PCR and Western blot. Senescence was evaluated by senescence-associated β-Galactosidase staining and by Western blot analysis of p16...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28007100/iris-fixation-of-posterior-chamber-intraocular-lenses
#6
Alireza Yazdani-Abyaneh, Ali R Djalilian, Masoud Aghsaei Fard
We introduce a technique for iris fixation of a posterior chamber intraocular lens (IOL) in which most of the procedure is done outside the eye. This minimizes intraocular manipulation, maximizes corneal endothelial preservation, and avoids the risk for IOL drop into the vitreous cavity intraoperatively. The IOL is fixated to the most peripheral part of the iris, resulting in a rounder pupil. Sutures are placed at exact positions on the haptics, resulting in a well-centered IOL. FINANCIAL DISCLOSURE: None of the authors has a financial or proprietary interest in any material or method mentioned...
December 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27911382/a-simple-mechanical-procedure-to-create-limbal-stem-cell-deficiency-in-mouse
#7
Neda Afsharkhamseh, Elham Ghahari, Medi Eslani, Ali R Djalilian
Limbal stem cell deficiency (LSCD) is a state of malfunction or loss of limbal epithelial stem cells, after which the corneal epithelium is replaced with conjunctiva. Patients suffer from recurrent corneal defects, pain, inflammation, and loss of vision. Previously, a murine model of LSCD was described and compared to two other models. The goal was to produce a consistent mouse model of LSCD that both mimics the phenotype in humans and lasts long enough to make it possible to study the disease pathophysiology and to evaluate new treatments...
November 17, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27668681/april-consultation-6
#8
Ali R Djalilian
No abstract text is available yet for this article.
April 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27650263/current-and-upcoming-therapies-for-ocular-surface-chemical-injuries
#9
REVIEW
Alireza Baradaran-Rafii, Medi Eslani, Zeeshan Haq, Ebrahim Shirzadeh, Michael J Huvard, Ali R Djalilian
Chemical injuries frequently result in vision loss, disfigurement, and challenging ocular surface complications. Acute interventions are directed at decreasing the extent of the injury, suppressing inflammation, and promoting ocular surface re-epithelialization. Chronically, management involves controlling inflammation along with rehabilitation and reconstruction of the ocular surface. Future therapies aimed at inhibiting neovascularization and promoting ocular surface regeneration should provide more effective treatment options for the management of ocular chemical injuries...
January 2017: Ocular Surface
https://www.readbyqxmd.com/read/27467047/late-acute-rejection-after-allograft-limbal-stem-cell-transplantation-evidence-for-long-term-donor-survival
#10
MULTICENTER STUDY
Medi Eslani, Zeeshan Haq, Asadolah Movahedan, Adam Moss, Alireza Baradaran-Rafii, Gautham Mogilishetty, Edward J Holland, Ali R Djalilian
PURPOSE: To describe the clinical presentation and management of late (>3.0 years) acute graft rejection in keratolimbal allograft (KLAL) recipients. METHODS: This was a multicenter, retrospective observational case series. Six eyes of 6 patients with ocular surface transplant at a mean age of 36.2 years were seen at 3 tertiary referral centers for acute graft rejection between 2007 and 2013. Main outcome measures included strength of systemic immunosuppression (SI) at the time of rejection, time to rejection, and clinical presentation of rejection...
January 2017: Cornea
https://www.readbyqxmd.com/read/27195077/keratoconus-a-true-corneal-disease
#11
Navid Ghassembaglou, Ali R Djalilian
No abstract text is available yet for this article.
January 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27179980/superior-limbic-keratoconjunctivitis-like-inflammation-in-patients-with-chronic-graft-versus-host-disease
#12
Kavitha R Sivaraman, Renu V Jivrajka, Ketki Soin, Charles S Bouchard, Asadolah Movahedan, Ellen Shorter, Sandeep Jain, Deborah S Jacobs, Ali R Djalilian
PURPOSE: Describe the presentation and management of superior limbic keratoconjunctivitis (SLK)-like inflammation and secondary limbal stem cell dysfunction in the setting of ocular chronic graft-versus-host disease (cGVHD). METHODS: Retrospective observational case series in a multicenter clinical practice. Participants were 13 patients (26 eyes) with ocular cGVHD and SLK-like inflammation presenting to the University of Illinois at Chicago and BostonSight® between January 1, 2009 and July 1, 2013...
July 2016: Ocular Surface
https://www.readbyqxmd.com/read/26943148/notch-signaling-in-meibomian-gland-epithelial-cell-differentiation
#13
Sanaz Gidfar, Neda Afsharkhamseh, Sara Sanjari, Ali R Djalilian
PURPOSE: Notch1 was previously shown to play a critical role in murine meibomian gland function and maintenance. In this study, we have examined the expression and activation of Notch pathway in human meibomian gland epithelial cells in vitro. METHODS: An immortalized human meibomian gland epithelial cell (HMGEC) line was cultured under proliferative and differentiative conditions. Expression of Notch receptors and ligands were evaluated by quantitative PCR and Western blot...
March 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26607808/stability-of-limbal-stem-cell-deficiency-after-mechanical-and-thermal-injuries-in-mice
#14
REVIEW
Neda Afsharkhamseh, Asadolah Movahedan, Sanaz Gidfar, Michael Huvard, Lisa Wasielewski, Behrad Y Milani, Medi Eslani, Ali R Djalilian
We studied the reproducibility and stability of limbal stem cell deficiency (LSCD) in mice following controlled injuries to the corneal and limbal epithelia. In one method, corneal and limbal epithelia were entirely removed with a 0.5 mm metal burr. In the other, limbus to limbus epithelial removal with the burr was followed by thermal injury to the limbus. These two methods were compared with a previously published one. Unwounded corneas were used as control. The corneas were examined monthly for three months by slit lamp with fluorescein staining...
April 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/25912399/heparanase-is-a-host-enzyme-required-for-herpes-simplex-virus-1-release-from-cells
#15
Satvik R Hadigal, Alex M Agelidis, Ghadah A Karasneh, Thessicar E Antoine, Abraam M Yakoub, Vishnu C Ramani, Ali R Djalilian, Ralph D Sanderson, Deepak Shukla
Herpesviruses exemplified by herpes simplex virus-1 (HSV-1) attach to cell surface heparan sulfate (HS) for entry into host cells. However, during a productive infection, the HS moieties on parent cells can trap newly exiting viral progenies and inhibit their release. Here we demonstrate that a HS-degrading enzyme of the host, heparanase (HPSE), is upregulated through NF-kB and translocated to the cell surface upon HSV-1 infection for the removal of HS to facilitate viral release. We also find a significant increase in HPSE release in vivo during infection of murine corneas and that knockdown of HPSE in vivo inhibits virus shedding...
2015: Nature Communications
https://www.readbyqxmd.com/read/25278791/cataract-surgery-in-patients-with-ocular-surface-disease-an-update-in-clinical-diagnosis-and-treatment
#16
Neda Afsharkhamseh, Asadolah Movahedan, Hooman Motahari, Ali R Djalilian
In this article we review essentials of diagnosis and management of ocular surface disease in patients who undergo cataract surgery. It is clearly shown that dry eye disease worsens following the cataract surgery in patients with prior history of ocular surface disease, Also new cases of dry eye might appear. Current strategies for the timely diagnosis and proper management of dry eye syndrome in the face of cataract surgery patients are mainly emphasized. To achieve the best outcome in cataract surgery, a healthy ocular surface is crucial...
July 2014: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/25183764/the-role-of-toll-like-receptor-4-in-corneal-epithelial-wound-healing
#17
Medi Eslani, Asadolah Movahedan, Neda Afsharkhamseh, Herve Sroussi, Ali R Djalilian
PURPOSE: We evaluated the role of Toll-like receptor 4 (TLR4) in corneal epithelial wound healing. METHODS: The expression of TLR4 during in vivo corneal epithelial wound healing was examined by immunostaining in mice. The expression and activation of TLR4 was studied in primary or telomerase-immortalized human corneal epithelial cells (HCEC). Scratch assay was performed to evaluate in vitro wound closure using live time-lapse microscopy. Transwell migration assay and Ki67 immunostaining were done to evaluate migration and proliferation, respectively...
September 2014: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/25105018/the-ocular-surface-chemical-burns
#18
REVIEW
Medi Eslani, Alireza Baradaran-Rafii, Asadolah Movahedan, Ali R Djalilian
Ocular chemical burns are common and serious ocular emergencies that require immediate and intensive evaluation and care. The victims of such incidents are usually young, and therefore loss of vision and disfigurement could dramatically affect their lives. The clinical course can be divided into immediate, acute, early, and late reparative phases. The degree of limbal, corneal, and conjunctival involvement at the time of injury is critically associated with prognosis. The treatment starts with simple but vision saving steps and is continued with complicated surgical procedures later in the course of the disease...
2014: Journal of Ophthalmology
https://www.readbyqxmd.com/read/24908203/medically-reversible-limbal-stem-cell-disease-clinical-features-and-management-strategies
#19
Bryan Y Kim, Kamran M Riaz, Pejman Bakhtiari, Clara C Chan, Jeffrey D Welder, Edward J Holland, Surendra Basti, Ali R Djalilian
PURPOSE: To describe the clinical features and management strategies in patients whose limbal stem cell (LSC) disease reversed with medical therapy. DESIGN: Retrospective case series. PARTICIPANTS: Twenty-two eyes of 15 patients seen at 3 tertiary referral centers between 2007 and 2011 with 3 months or more of follow-up. METHODS: Medical records of patients with medically reversible LSC disease were reviewed. Demographic data, causes, location and duration of disease, and medical inventions were analyzed...
October 2014: Ophthalmology
https://www.readbyqxmd.com/read/24653823/ocular-graft-versus-host-disease-following-allogeneic-stem-cell-transplantation-a-review-of-current-knowledge-and-recommendations
#20
REVIEW
Nariman Nassiri, Medi Eslani, Nekoo Panahi, Shiva Mehravaran, Alireza Ziaei, Ali R Djalilian
Graft versus host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). Ocular GVHD develops in approximately 40-60% of patients following allo-SCT and its most common clinical manifestations include keratoconjunctivitis sicca and cicatricial conjunctivitis. Ocular GVHD may lead to severe ocular surface disease, which can significantly diminish quality of life and restrict daily activities. It is thus important to monitor the condition closely since with timely diagnosis, irreversible damage can be avoided...
October 2013: Journal of Ophthalmic & Vision Research
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