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pedram hamrah

Pedram Hamrah, Yashar Seyed-Razavi, Takefumi Yamaguchi
Corneal immunoimaging and neuroimaging approaches facilitate in vivo analyses of the cornea, including high-resolution imaging of corneal immune cells and nerves. This approach facilitates the analyses of underlying immune and nerve alterations not detected by clinical slit-lamp examination alone. In this review, we describe recent work performed in our translational ocular immunology center with a focus on "bench-to-bedside" and "bedside-to-bench" research. The ability to visualize dendritiform immune cells (DCs) in patients with laser in vivo confocal microscopy (IVCM), recently discovered in the central murine cornea, has allowed us to demonstrate their utility as a potential surrogate biomarker for inflammatory ocular surface diseases...
November 2016: Cornea
Takefumi Yamaguchi, Pedram Hamrah, Jun Shimazaki
This review summarizes the recent literature regarding corneal imaging in human subjects using in vivo confocal microscopy. It also covers the recent literature on corneal immune cells, nerves, and tear cytokine levels in ocular surface diseases as well as corneal immune privilege. The significance of interactions between corneal immune cells and nerves in health, neurotrophic keratopathy, and infectious keratitis is discussed. Furthermore, bilateral alterations of immune cells and nerves in clinically unilateral corneal diseases and the link to changes of tear cytokines or neuropeptide levels in contralateral eyes are described...
November 2016: Cornea
Faith A Birnbaum, Pedram Hamrah, Deborah S Jacobs, Brian J Song
PURPOSE: Corneal neuropathy is a recently described disease process that is not well understood and is likely underdiagnosed as a result. This is the first reported case of an acquired corneal neuropathy associated with malposition of an Ex-PRESS shunt. METHODS: A single case report. RESULTS: We report the case of a 50-year-old man with a history of multiple procedures for glaucoma who subsequently developed photoallodynia and corneal neuropathy in association with malposition of an Ex-PRESS shunt in the peripheral cornea...
August 2, 2016: Journal of Glaucoma
Wei-Sheng Chen, Zhiyi Cao, Satoshi Sugaya, Maria J Lopez, Victor G Sendra, Nora Laver, Hakon Leffler, Ulf J Nilsson, Jianxin Fu, Jianhua Song, Lijun Xia, Pedram Hamrah, Noorjahan Panjwani
No abstract text is available yet for this article.
2016: Nature Communications
Roberto Annunziata, Ahmad Kheirkhah, Shruti Aggarwal, Pedram Hamrah, Emanuele Trucco
Recent clinical research has highlighted important links between a number of diseases and the tortuosity of curvilinear anatomical structures like corneal nerve fibres, suggesting that tortuosity changes might detect early stages of specific conditions. Currently, clinical studies are mainly based on subjective, visual assessment, with limited repeatability and inter-observer agreement. To address these problems, we propose a fully automated framework for image-level tortuosity estimation, consisting of a hybrid segmentation method and a highly adaptable, definition-free tortuosity estimation algorithm...
August 2016: Medical Image Analysis
Yureeda Qazi, Shelley Hurwitz, Sarosh Khan, Ula V Jurkunas, Reza Dana, Pedram Hamrah
PURPOSE: To validate the Ocular Pain Assessment Survey (OPAS), specifically designed to measure ocular pain and quality of life for use by eye care practitioners and researchers. DESIGN: A single-center cohort study was conducted among patients with and without corneal and ocular surface pain at initial and follow-up visits over a 6-month period. The content of the OPAS was guided by literature review, a body of experts, and incorporating conceptual frameworks from existing pain questionnaires...
July 2016: Ophthalmology
Tulio B Abud, Francisco Amparo, Ujwala S Saboo, Antonio Di Zazzo, Thomas H Dohlman, Joseph B Ciolino, Pedram Hamrah, Reza Dana
PURPOSE: To evaluate the safety and efficacy of topical tacrolimus 0.05% versus topical methylprednisolone 0.5% in patients with ocular graft-versus-host disease (GVHD). DESIGN: Phase 1/2 prospective, randomized, double-masked clinical trial. PARTICIPANTS: Eighty eyes of 40 patients diagnosed with chronic ocular GVHD were enrolled. METHODS: Forty patients with ocular GVHD were randomized; 24 patients were treated with topical tacrolimus 0...
July 2016: Ophthalmology
Wei-Sheng Chen, Zhiyi Cao, Satoshi Sugaya, Maria J Lopez, Victor G Sendra, Nora Laver, Hakon Leffler, Ulf J Nilsson, Jianxin Fu, Jianhua Song, Lijun Xia, Pedram Hamrah, Noorjahan Panjwani
Lymphangiogenesis plays a pivotal role in diverse pathological conditions. Here, we demonstrate that a carbohydrate-binding protein, galectin-8, promotes pathological lymphangiogenesis. Galectin-8 is markedly upregulated in inflamed human and mouse corneas, and galectin-8 inhibitors reduce inflammatory lymphangiogenesis. In the mouse model of corneal allogeneic transplantation, galectin-8-induced lymphangiogenesis is associated with an increased rate of corneal graft rejection. Further, in the murine model of herpes simplex virus keratitis, corneal pathology and lymphangiogenesis are ameliorated in Lgals8(-/-) mice...
2016: Nature Communications
Andrea Cruzat, Pedram Hamrah, Bernardo M Cavalcanti, Lixin Zheng, Kathryn Colby, Deborah Pavan-Langston
PURPOSE: To study corneal reinnervation and sensation recovery in Herpes zoster ophthalmicus (HZO). METHODS: Two patients with HZO were studied over time with serial corneal esthesiometry and laser in vivo confocal microscopy (IVCM). A Boston keratoprosthesis type 1 was implanted, and the explanted corneal tissues were examined by immunofluorescence histochemistry for βIII-tubulin to stain for corneal nerves. RESULTS: The initial central corneal IVCM performed in each patient showed a complete lack of the subbasal nerve plexus, which was in accordance with severe loss of sensation (0 of 6 cm) measured by esthesiometry...
May 2016: Cornea
Nora W Muakkassa, Kendra A Klein, Pedram Hamrah, Elias Reichel
The authors present a case of keratoprosthesis-associated cystoid macular edema (CME) responsive to subconjunctival bevacizumab (Avastin; Genentech, South San Francisco, CA). A 40-year-old woman with a history of Stevens-Johnson syndrome (SJS) and Boston keratoprosthesis type I implantation developed CME 10 months after surgery and received sub-Tenon's kenalog with minimal improvement. Sixteen months after surgery, she received a subconjunctival injection of bevacizumab and demonstrated visual and anatomic improvement...
March 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Roberto Annunziata, Ahmad Kheirkhah, Shruti Aggarwal, Bernardo M Cavalcanti, Pedram Hamrah, Emanuele Trucco
PURPOSE: To assess the performance of a novel system for automated tortuosity estimation and interpretation. METHODS: A supervised strategy (driven by observers' grading) was employed to automatically identify the combination of tortuosity measures (i.e., tortuosity representation) leading to the best agreement with the observers. We investigated 18 tortuosity measures including curvature and density of inflection points, computed at multiple spatial scales. To leverage tortuosity interpretation, we propose the tortuosity plane (TP) onto which each image is mapped...
March 2016: Investigative Ophthalmology & Visual Science
Sunali Goyal, Pedram Hamrah
The richly innervated corneal tissue is one of the most powerful pain generators in the body. Corneal neuropathic pain results from dysfunctional nerves causing perceptions such as burning, stinging, eye-ache, and pain. Various inflammatory diseases, neurological diseases, and surgical interventions can be the underlying cause of corneal neuropathic pain. Recent efforts have been made by the scientific community to elucidate the pathophysiology and neurobiology of pain resulting from initially protective physiological reflexes, to a more persistent chronic state...
2016: Seminars in Ophthalmology
Thomas H Dohlman, Antonio Di Zazzo, Masahiro Omoto, Jing Hua, Julia Ding, Pedram Hamrah, Sunil K Chauhan, Reza Dana
BACKGROUND: Immune rejection continues to threaten all tissue transplants. Here we sought to determine whether platelet (P)- and endothelial (E)-selectin mediate T cell recruitment in corneal transplantation and whether their blockade can reduce T cell graft infiltration and improve long-term corneal allograft survival. METHODS: In a murine model of allogeneic corneal transplantation, we used PCR and immunohistochemistry to investigate expression of P- and E-selectin in rejected versus accepted allografts and lymph node flow cytometry to assess expression of selectin ligands by effector T cells...
April 2016: Transplantation
Roberto Annunziata, Ahmad Kheirkhah, Pedram Hamrah, Emanuele Trucco
We propose a new approach to corneal nerve fibre centreline detection for in vivo confocal microscopy images. Relying on a combination of efficient hand-crafted features and learned filters, our method offers an excellent compromise between accuracy and running time. Unlike previous solutions using sparse coding to learn small filter banks, we employ K-means to efficiently learn the high amount of filters needed to cope with the multiple challenges involved, e.g., low contrast and resolution, non-uniform illumination, tortuosity and confounding non-target structures...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Ahmad Kheirkhah, Raheleh Rahimi Darabad, Andrea Cruzat, Amir Reza Hajrasouliha, Deborah Witkin, Nadia Wong, Reza Dana, Pedram Hamrah
PURPOSE: To evaluate density and morphology of corneal epithelial immune dendritic cells (DCs) in different subtypes of dry eye disease (DED) using in vivo confocal microscopy (IVCM). METHODS: This retrospective study included 59 eyes of 37 patients with DED and 40 eyes of 20 age-matched healthy controls. Based on clinical tests, eyes with DED were categorized into two subtypes: aqueous-deficient (n = 35) and evaporative (n = 24). For all subjects, images of laser scanning in vivo confocal microscopy (IVCM) of the central cornea were analyzed for DC density and DC morphology (DC size, number of dendrites, and DC field)...
November 2015: Investigative Ophthalmology & Visual Science
Shruti Aggarwal, Takefumi Yamaguchi, Reza Dana, Pedram Hamrah
PURPOSE: Corneal infections, particularly fungal keratitis due to rare fungal species, pose a diagnostic and therapeutic challenge because of difficulty in identification and varying susceptibility profiles. In this study, we report the first case of fungal keratitis because of Exophiala phaeomuriformis. METHODS: We report the clinical findings and microbial identification techniques of a case of fungal keratitis due to E. phaeomuriformis. An 84-year-old woman presented with redness, pain, and itching in the left eye for 2 weeks...
October 27, 2015: Eye & Contact Lens
Andrea Cruzat, Wolfgang A Schrems, Laura M Schrems-Hoesl, Bernardo M Cavalcanti, Neda Baniasadi, Deborah Witkin, Deborah Pavan-Langston, Reza Dana, Pedram Hamrah
PURPOSE: To analyze the contralateral unaffected eyes of patients with microbial keratitis (MK) for any immune cell or nerve changes by laser in vivo confocal microscopy (IVCM). METHODS: A prospective study was performed on 28 patients with MK, including acute bacterial, fungal, and Acanthamoeba keratitis, as well as on their contralateral clinically unaffected eyes and on control groups, which consisted of 28 age-matched normal controls and 15 control contact lens (CL) wearers...
October 2015: Investigative Ophthalmology & Visual Science
Kai Hu, Deshea L Harris, Takefumi Yamaguchi, Ulrich H von Andrian, Pedram Hamrah
The cornea is the shield to the foreign world and thus, a primary site for peripheral infections. However, transparency and vision are incompatible with inflammation and scarring that may result from infections. Thus, the cornea is required to perform a delicate balance between fighting infections and preserving vision. To date, little is known about the specific role of antigen-presenting cells in viral keratitis. In this study, utilizing an established murine model of primary acute herpes simplex virus (HSV)-1 keratitis, we demonstrate that primary HSV keratitis results in increased conventional dendritic cells (cDCs) and macrophages within 24 hours after infection...
2015: PloS One
Ahmad Kheirkhah, Rodrigo Muller, Janine Mikolajczak, Ai Ren, Ella Maria Kadas, Hanna Zimmermann, Harald Pruess, Friedemann Paul, Alexander U Brandt, Pedram Hamrah
PURPOSE: To evaluate whether the densities of corneal subbasal nerves and epithelial immune dendritiform cells (DCs) are comparable between a set of three representative standard images of in vivo confocal microscopy (IVCM) and the wide-field mapped composite IVCM images. METHODS: This prospective, cross-sectional, and masked study included 110 eyes of 58 patients seen in a neurology clinic who underwent laser-scanning IVCM (Heidelberg Retina Tomograph 3) of the central cornea...
September 2015: Investigative Ophthalmology & Visual Science
Rodrigo T Müller, Farshad Abedi, Andrea Cruzat, Deborah Witkin, Neda Baniasadi, Bernardo M Cavalcanti, Arsia Jamali, James Chodosh, Reza Dana, Deborah Pavan-Langston, Pedram Hamrah
PURPOSE: To investigate the longitudinal alterations of subbasal corneal nerves in patients with infectious keratitis (IK) during the acute phase, cessation of treatment, and the recovery phase by in vivo confocal microscopy (IVCM). DESIGN: Prospective, longitudinal, case-control, single-center study. PARTICIPANTS: Fifty-six eyes of 56 patients with the diagnosis of bacterial (n=28), fungal (n=15), or Acanthamoeba (n=13) keratitis were included in the study...
November 2015: Ophthalmology
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