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T-cell and exercise

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https://www.readbyqxmd.com/read/28516080/cutaneous-anaplastic-large-t-cell-lymphoma-with-invasion-of-the-central-nervous-system-a-case-report
#1
Hyun-Nam Seo, Jin-Ho Seo, Cheol-Young Lee, Jihye Song, Jong-Hyun Kim, Hyun-Woo Kim
Anaplastic large T-cell lymphoma (ALCL) encompasses different clinical entities that can be aggressive or localized. Scalp anaplastic lymphoma kinase (ALK)-negative ALCL is considered a localized lymphoma, and usually extends to the regional lymph nodes; intracranial invasion is rare. A 74-year-old woman was diagnosed with scalp ALK-negative ALCL, but did not exhibit invasion of the lymph nodes. Computed tomography and magnetic resonance imaging revealed intracranial masses with bony erosions. We treated the patient using CHOP chemotherapy and achieved short-term regression of the scalp and intracranial lesions...
April 2017: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/28503368/running-wheel-training-does-not-change-neurogenesis-levels-or-alter-working-memory-tasks-in-adult-rats
#2
Cesar A Acevedo-Triana, Manuel J Rojas, Fernando Cardenas P
BACKGROUND: Exercise can change cellular structure and connectivity (neurogenesis or synaptogenesis), causing alterations in both behavior and working memory. The aim of this study was to evaluate the effect of exercise on working memory and hippocampal neurogenesis in adult male Wistar rats using a T-maze test. METHODS: An experimental design with two groups was developed: the experimental group (n = 12) was subject to a forced exercise program for five days, whereas the control group (n = 9) stayed in the home cage...
2017: PeerJ
https://www.readbyqxmd.com/read/28486836/inverse-relationship-between-vitamin-d-levels-and-platelet-indices-in-korean-adults
#3
Yon Chul Park, Jin Kim, Min Seok Seo, Sung Won Hong, Eun Seok Cho, Jong-Koo Kim
BACKGROUND AND AIMS: Vitamin D deficiency and increased platelet indices are associated with increased rate or risk of several diseases such as cardiovascular disease and metabolic syndrome, respectively. We investigated whether vitamin D deficiency is associated with increased platelet count (PC) and mean platelet volume (MPV). METHODS AND RESULTS: The study included 3190 subjects older than 20 years. Subjects were divided into three groups based on their vitamin D levels: vitamin D deficiency (<10...
May 10, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28475846/resistance-exercise-attenuates-skeletal-muscle-oxidative-stress-systemic-pro-inflammatory-state-and-cachexia-in-walker-256-tumor-bearing-rats
#4
Camila Souza Padilha, Fernando H Borges, Lilian Eslaine Costa Mendes da Silva, Fernando Tadeu Trevisan Frajacomo, Alceu Afonso Jordao, José Alberto Duarte, Rubens Cecchini, Flávia Alessandra Guarnier, Rafael Deminice
The aim of this study was to investigate the effects of resistance exercise training (RET) on oxidative stress, systemic inflammatory markers and muscle wasting in Walker-256 tumor-bearing rats. Male (Wistar) rats were divided into 4 groups: sedentary controls (n=9); tumor-bearing (n=9); exercised (n=9); and tumor-bearing exercised (n=10). Exercised and tumor-bearing exercised rats were exposed to resistance exercise of climbing a ladder apparatus with weights tied to their tails during 6-wks. The physical activity of control and tumor-bearing rats was confined to the space of the cage...
May 5, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28465117/a-novel-splice-site-hcn4-gene-mutation-c-1737-1-g-t-causes-familial-bradycardia-reduced-heart-rate-response-impaired-chronotropic-competence-and-increased-short-term-heart-rate-variability
#5
Lidia Hategan, Beáta Csányi, Balázs Ördög, Kornél Kákonyi, Annamária Tringer, Orsolya Kiss, Andrea Orosz, László Sághy, István Nagy, Zoltán Hegedűs, László Rudas, Márta Széll, András Varró, Tamás Forster, Róbert Sepp
BACKGROUND: The most important molecular determinant of heart rate regulation in sino-atrial pacemaker cells includes hyperpolarization-activated, cyclic nucleotide-gated ion channels, the major isoform of which is encoded by the HCN4 gene. Mutations affecting the HCN4 gene are associated primarily with sick sinus syndrome. METHODS AND RESULTS: A novel c.1737+1 G>T 'splice-site' HCN4 mutation was identified in a large family with familial bradycardia which co-segregated with the disease providing a two-point LOD score of 4...
April 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28429777/interleukin-6-increases-the-expression-and-activity-of-insulin-degrading-enzyme
#6
Mirian A Kurauti, José M Costa-Júnior, Sandra M Ferreira, Gustavo J Santos, Carlos H G Sponton, Everardo M Carneiro, Guilherme D Telles, Mara P T Chacon-Mikahil, Cláudia R Cavaglieri, Luiz F Rezende, Antonio C Boschero
Impairment of the insulin-degrading enzyme (IDE) is associated with obesity and type 2 diabetes mellitus (T2DM). Here, we used 4-mo-old male C57BL/6 interleukin-6 (IL-6) knockout mice (KO) to investigate the role of this cytokine on IDE expression and activity. IL-6 KO mice displayed lower insulin clearance in the liver and skeletal muscle, compared with wild type (WT), due to reduced IDE expression and activity. We also observed that after 3-h incubation, IL-6, 50 and 100 ng ml(-1), increased the expression of IDE in HEPG2 and C2C12 cells, respectively...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428879/a-systems-biology-approach-to-investigating-the-influence-of-exercise-and-fitness-on-the-composition-of-leukocytes-in-peripheral-blood
#7
Michael P Gustafson, Ara Celi DiCostanzo, Courtney M Wheatley, Chul-Ho Kim, Svetlana Bornschlegl, Dennis A Gastineau, Bruce D Johnson, Allan B Dietz
BACKGROUND: Exercise immunology has become a growing field in the past 20 years, with an emphasis on understanding how different forms of exercise affect immune function. Mechanistic studies are beginning to shed light on how exercise may impair the development of cancer or be used to augment cancer treatment. The beneficial effects of exercise on the immune system may be exploited to improve patient responses to cancer immunotherapy. METHODS: We investigated the effects of acute exercise on the composition of peripheral blood leukocytes over time in a male population of varying fitness...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28417620/effects-of-submaximal-aerobic-exercise-on-regulatory-t-cell-markers-of-male-patients-suffering-from-ischemic-heart-disease
#8
Fariba Raygan, Mansour Sayyah, Seyed Mohammad Reza Janesar Qamsari, Hassan Nikoueinejad, Mojtaba Sehat
There are confirmed beneficiary effects of exercise on atherosclerotic inflammation of ischemia-associated heart diseases. The purpose of this study was to evaluate the effect of aerobic exercise on T-regulatory cell markers of IL-35 as well as FoxP3 and T-helper2 marker of IL-33 in patients with ischemic heart disease (IHD). This research was performed on 44 asymptomatic male patients with ischemic heart disease. The participants were randomly assigned into two groups of submaximal aerobic exercise and control group...
February 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28415917/exercise-rehabilitation-immediately-following-ischemic-stroke-exacerbates-inflammatory-injury
#9
Fengwu Li, John T Pendy, Jessie N Ding, Changya Peng, Xiaorong Li, Jiamei Shen, Sainan Wang, Xiaokun Geng
OBJECTIVES: The rehabilitative benefits of physical exercise after stroke appear to be contingent upon exercise initiation timing. The present study assessed the hypothesis that very early post-stroke exercise would amplify cellular stress and increases expression of pro-inflammatory mediators, while exercise initiated later would limit the inflammation associated with cerebral ischemia/reperfusion injury. METHODS: Adult rats were subjected to middle cerebral artery occlusion and subsequently assigned to one of seven groups: one sham injury control group, three stroke groups subjected to exercise initiated after 6, 24 hours, or 3 days of reperfusion, and three stroke groups not subjected to exercise...
June 2017: Neurological Research
https://www.readbyqxmd.com/read/28391394/lifelong-training-improves-anti-inflammatory-environment-and-maintains-the-number-of-regulatory-t-cells-in-masters-athletes
#10
Luciele G Minuzzi, Luis Rama, Nicolette C Bishop, Fátima Rosado, António Martinho, Artur Paiva, Ana M Teixeira
PURPOSE: The purpose of this study was to quantify and characterize peripheral blood regulatory T cells (Tregs), as well as the IL-10 plasma concentration, in Masters athletes at rest and after an acute exhaustive exercise test. METHODS: Eighteen Masters athletes (self-reported training: 24.6 ± 1.83 years; 10.27 ± 0.24 months and 5.45 ± 0.42 h/week per each month trained) and an age-matched control group of ten subjects (that never took part in regular physical training) volunteered for this study...
June 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28379266/keto-analogues-and-amino-acids-supplementation-induces-a-decrease-of-white-blood-cell-counts-and-a-reduction-of-muscle-damage-during-intense-exercise-under-thermoneutral-conditions
#11
R C P Lima, S R A S Camerino, T C L França, D S A Rodrigues, M G S Gouveia, A Ximenes-da-Silva, A Bassini, E S Prado, L C Cameron
This study evaluated the acute effect of keto analogue and amino acid (AA-KAAA) supplementation on both white blood cell counts and the established biomarkers of muscle damage during exercise under thermoneutral conditions. Sixteen male cyclists received a ketogenic diet for two days and were divided into two equal groups: a group taking AA-KAAA (KA) or a control group (PL). The athletes performed a two hour cycling session followed by a maximum incremental test until voluntary exhaustion (VExh). Blood samples were obtained at rest and during exercise for further hematological and biochemical analyses...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28377874/global-mrna-sequencing-of-human-skeletal-muscle-search-for-novel-exercise-regulated-myokines
#12
S Pourteymour, K Eckardt, T Holen, T Langleite, Sindre Lee, J Jensen, K I Birkeland, C A Drevon, M Hjorth
OBJECTIVE: Skeletal muscle is an important secretory organ, producing and releasing numerous myokines, which may be involved in mediating beneficial health effects of physical activity. More than 100 myokines have been identified by different proteomics approaches, but these techniques may not detect all myokines. We used mRNA sequencing as an untargeted approach to study gene expression of secreted proteins in skeletal muscle upon acute as well as long-term exercise. METHODS: Twenty-six middle-aged, sedentary men underwent combined endurance and strength training for 12 weeks...
April 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28373911/feasibility-of-high-intensity-interval-training-and-moderate-intensity-continuous-training-in-adults-with-inactive-or-mildly-active-crohn-s-disease-study-protocol-for-a-randomised-controlled-trial
#13
Garry A Tew, Roger Carpenter, Michael Seed, Simon Anderson, Louise Langmead, Caroline Fairhurst, Lindsay Bottoms
BACKGROUND: Structured exercise training has been proposed as a useful adjunctive therapy for Crohn's disease by improving immune function and psychological health, reducing fatigue and promoting gains in muscle and bone strength. However, the evidence for exercise in Crohn's disease is sparse, with only a handful of small prospective trials [1, 2], with methodological limitations, including the use of non-randomised and non-controlled study designs and small sample sizes. Here, we describe the protocol for a study that aims to assess the feasibility and acceptability of two common types of exercise training-high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)-in adults with inactive or mildly active Crohn's disease (CD)...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28366645/t-cell-activation-and-proliferation-following-acute-exercise-in-human-subjects-is-altered-by-storage-conditions-and-mitogen-selection
#14
Jacob A Siedlik, Jake A Deckert, Stephen H Benedict, Anuja Bhatta, Amanda J Dunbar, John P Vardiman, Philip M Gallagher
Recent work investigating exercise induced changes in immunocompetence suggests that some of the ambiguity in the literature is resultant from different cell isolation protocols and mitogen selection. To understand this effect, we compared post-exercise measures of T cell activation and proliferation using two different stimulation methods (costimulation through CD28 or stimulation with phytohaemagglutinin [PHA]). Further, we investigated whether exercise induced changes are maintained when T cell isolation from whole blood is delayed overnight in either a room temperature or chilled (4°C) environment...
March 30, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28362366/flow-cytometric-analysis-of-natural-killer-cell-lytic-activity-in-human-whole-blood
#15
Jennifer E McBride, Mary P Meaney, Casey John, David C Nieman, Renaud F Warin
NK cell cytotoxicity is a widely used measure to determine the effect of outside intervention on NK cell function. However, the accuracy and reproducibility of this assay can be considered unstable, either because of user's errors or because of the sensitivity of NK cells to experimental manipulation. To eliminate these issues, a workflow that reduces them to a minimum was established and is presented here. To illustrate, we obtained blood samples, at various time points, from runners (n = 4) that were submitted to an intense bout of exercise...
March 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28346813/protein-supplementation-does-not-affect-myogenic-adaptations-to-resistance-training
#16
Paul T Reidy, Christopher S Fry, Sherry Igbinigie, Rachel R Deer, Kristofer Jennings, Mark B Cope, Ratna Mukherjea, Elena Volpi, Blake B Rasmussen
It has been proposed that protein supplementation during resistance exercise training enhances muscle hypertrophy. The degree of hypertrophy during training is controlled in part through the activation of satellite cells and myonuclear accretion. PURPOSE: This study aimed to determine the efficacy of protein supplementation (and the type of protein) during traditional resistance training on myofiber cross-sectional area, satellite cell content, and myonuclear addition. METHODS: Healthy young men participated in supervised whole-body progressive resistance training 3 d·wk for 12 wk...
June 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28345617/stimulation-of-adult-hippocampal-neurogenesis-by-physical-exercise-and-enriched-environment-is-disturbed-in-a-cadasil-mouse-model
#17
C Klein, S Schreyer, F E Kohrs, P Elhamoury, A Pfeffer, T Munder, B Steiner
In the course of CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), a dysregulated adult hippocampal neurogenesis has been suggested as a potential mechanism for early cognitive decline. Previous work has shown that mice overexpressing wild type Notch3 and mice overexpressing Notch3 with a CADASIL mutation display impaired cell proliferation and survival of newly born hippocampal neurons prior to vascular abnormalities. Here, we aimed to elucidate how the long-term survival of these newly generated neurons is regulated by Notch3...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28344975/equine-dental-pulp-connective-tissue-particles-reduced-lameness-in-horses-in-a-controlled-clinical-trial
#18
Alicia L Bertone, Nathalie A Reisbig, Allison H Kilborne, Mari Kaido, Navid Salmanzadeh, Rebecca Lovasz, Joy L Sizemore, Logan Scheuermann, Rosalind J Kopp, Lisa J Zekas, Matthew T Brokken
OBJECTIVE: To assess if injection of allogeneic dental pulp tissue particles would improve lameness in horses with naturally occurring osteoarthritis (OA) or soft tissue (ST) injury. DESIGN: Prospective, randomized, blinded, and controlled clinical trial and client survey assessment. ANIMALS: Forty lame client-owned horses. PROCEDURES: Sterile dental pulp, recovered from otherwise healthy foals that perish during dystocia, was processed under good manufacturing processing to produce mechanically manipulated, unexpanded pulp tissue particles containing viable cells surrounded in extracellular matrix...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28329660/predictors-of-tanning-dependence-in-white-non-hispanic-females-and-males
#19
Brenda Cartmel, Susan T Mayne, Allen E Bale, Joel Gelernter, Andrew DeWan, David J Leffell, Sherry Pagoto, Peter Spain, Leah M Ferrucci
Growing evidence suggests some individuals may exhibit dependence to ultraviolet light, a known carcinogen; however, few studies have investigated predictors of tanning dependence (TD).A sub-set of early-onset basal cell carcinoma case-control study participants completed an online survey. The modified-Cut down, Annoyed, Guilty, Eye-opener (mCAGE) and a questionnaire based on the addiction criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (mDSM-IV-TR) were used to classify participants having'Symptoms of TD' if they met criteria for TD on both questionnaires, 'Tendency for TD' if met criteria on only one questionnaire, or 'Not TD'...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28319586/short-term-exercise-training-alters-leukocyte-chemokine-receptors-in-obese-adults
#20
Julianne C Barry, Svetlana Simtchouk, Cody Durrer, Mary E Jung, Jonathan P Little
Obesity is characterized by chronic low-grade inflammation driven by activation and tissue infiltration of circulating leukocytes. Although exercise has anti-inflammatory effects, the impact of exercise on mediators of leukocyte migration is unclear. PURPOSE: To determine the impact of high intensity interval training (HIIT) versus moderate intensity continuous training (MICT), in the absence of weight/fat loss, on circulating chemokines and leukocyte chemokine receptors. METHODS: Thirty-seven inactive obese adults were randomized to two weeks (10 sessions) of HIIT or MICT with fasting blood samples collected before and after training...
March 18, 2017: Medicine and Science in Sports and Exercise
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