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T-cell and exercise

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https://www.readbyqxmd.com/read/28767980/bone-marrow-cell-migration-to-the-heart-in-a-chimeric-mouse-model-of-acute-chagasic-disease
#1
Camila Iansen Irion, Bruno Diaz Paredes, Guilherme Visconde Brasil, Sandro Torrentes da Cunha, Luis Felipe Paula, Alysson Roncally Carvalho, Antonio Carlos Campos de Carvalho, Adriana Bastos Carvalho, Regina Coeli Dos Santos Goldenberg
BACKGROUND: Chagas disease is a public health problem caused by infection with the protozoan Trypanosoma cruzi. There is currently no effective therapy for Chagas disease. Although there is some evidence for the beneficial effect of bone marrow-derived cells in chagasic disease, the mechanisms underlying their effects in the heart are unknown. Reports have suggested that bone marrow cells are recruited to the chagasic heart; however, studies using chimeric mouse models of chagasic cardiomyopathy are rare...
August 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28760151/pureair-protocol-randomized-controlled-trial-of-intensive-pulmonary-rehabilitation-versus-standard-care-in-patients-undergoing-surgical-resection-for-lung-cancer
#2
Stefania Fugazzaro, Stefania Costi, Carlotta Mainini, Besa Kopliku, Cristian Rapicetta, Roberto Piro, Roberta Bardelli, Patricia Filipa Sobral Rebelo, Carla Galeone, Giorgio Sgarbi, Filippo Lococo, Massimiliano Paci, Tommaso Ricchetti, Silvio Cavuto, Domenico Franco Merlo, Sara Tenconi
BACKGROUND: Non-small cell lung cancer is the most common type of lung cancer. Surgery is proven to be the most effective treatment in early stages, despite its potential impact on quality of life. Pulmonary rehabilitation, either before or after surgery, is associated with reduced morbidity related symptoms and improved exercise capacity, lung function and quality of life. METHODS: We describe the study protocol for the open-label randomized controlled trial we are conducting on patients affected by primary lung cancer (stages I-II) eligible for surgical treatment...
July 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28755471/mechanical-loading-disrupts-osteocyte-plasma-membranes-which-initiates-mechanosensation-events-in-bone
#3
Kanglun Yu, David P Sellman, Anoosh Bahraini, Mackenzie L Hagan, Ahmed Elsherbini, Kayce T Vanpelt, Peyton L Marshall, Mark W Hamrick, Anna McNeil, Paul L McNeil, Meghan E McGee-Lawrence
Osteocytes sense loading in bone, but their mechanosensation mechanisms remain poorly understood. Plasma membrane disruptions (PMD) develop with loading under physiological conditions in many cell types (e.g., myocytes, endothelial cells). These PMD foster molecular flux across cell membranes that promotes tissue adaptation, but this mechanosensation mechanism had not been explored in osteocytes. Our goal was to investigate whether PMD occur and initiate consequent mechanotransduction in osteocytes during physiological loading...
July 29, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28751932/does-regular-exercise-counter-t-cell-immunosenescence-reducing-the-risk-of-developing-cancer-and-promoting-successful-treatment-of-malignancies
#4
REVIEW
James E Turner, Patricia C Brum
Moderate intensity aerobic exercise training or regular physical activity is beneficial for immune function. For example, some evidence shows that individuals with an active lifestyle exhibit stronger immune responses to vaccination compared to those who are inactive. Encouragingly, poor vaccine responses, which are characteristic of an ageing immune system, can be improved by single or repeated bouts of exercise. In addition, exercise-induced lymphocytosis, and the subsequent lymphocytopenia, is thought to facilitate immune surveillance, whereby lymphocytes search tissues for antigens derived from viruses, bacteria, or malignant transformation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28746573/quality-of-life-socioeconomic-and-clinical-factors-and-physical-exercise-in-persons-living-with-hiv-aids
#5
Rafaela Catherine da Silva Cunha de Medeiros, Jason Azevedo de Medeiros, Tatiane Andreza Lima da Silva, Ricardo Dias de Andrade, Danielle Coutinho de Medeiros, Juliany de Souza Araújo, Antônio Manuel Gouveia de Oliveira, Marcos Aurélio de Albuquerque Costa, Paulo Moreira Silva Dantas
OBJECTIVE: To analyze whether socioeconomic and clinical aspects and the aspects of healthy life habits are associated with the quality of life of persons living with HIV/AIDS. METHODS: This is a cross-sectional exploratory quantitative research, with 227 persons living with HIV/AIDS, treated at two hospitals of reference between April 2012 and June 2014. We used structured questionnaires to assess socioeconomic aspects (gender, age, education level, marital status, race, socioeconomic status, dependents on family income, employment relationship), clinical parameters (time of disease diagnosis, use and time of medication, CD4 T-cell count, and viral load), and practice of physical exercise...
July 20, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28739540/the-women-in-steady-exercise-research-wiser-survivor-trial-the-innovative-transdisciplinary-design-of-a-randomized-controlled-trial-of-exercise-and-weight-loss-interventions-among-breast-cancer-survivors-with-lymphedema
#6
Renate M Winkels, Kathleen M Sturgeon, Michael J Kallan, Lorraine T Dean, Zi Zhang, Margaret Evangelisti, Justin C Brown, David B Sarwer, Andrea B Troxel, Crystal Denlinger, Monica Laudermilk, Anna Fornash, Angela DeMichele, Lewis A Chodosh, Kathryn H Schmitz
INTRODUCTION: Breast cancer survivors face dual challenges: long term sequelae of treatment, and risk of recurrent disease. Obesity and a sedentary lifestyle complicate both challenges. The WISER Survivor trial assessed the effects of exercise and/or weight-loss on lymphedema, biomarkers of breast cancer recurrence, and quality of life. We report on the innovative transdisciplinary design of this trial and report attrition rates. METHODS: This one year trial randomized breast cancer survivors who had a BMI of ≥25kg/m(2), were sedentary and had breast-cancer-related-lymphedema to 1) exercise (weight training and aerobic exercise) 2) weight-loss 3) exercise and weight-loss 4) or control group...
July 21, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28712726/sengers-syndrome-associated-mitochondrial-acylglycerol-kinase-is-a-subunit-of-the-human-tim22-protein-import-complex
#7
Yilin Kang, David A Stroud, Michael J Baker, David P De Souza, Ann E Frazier, Michael Liem, Dedreia Tull, Suresh Mathivanan, Malcolm J McConville, David R Thorburn, Michael T Ryan, Diana Stojanovski
Acylglycerol kinase (AGK) is a mitochondrial lipid kinase that catalyzes the phosphorylation of monoacylglycerol and diacylglycerol to lysophosphatidic acid and phosphatidic acid, respectively. Mutations in AGK cause Sengers syndrome, which is characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Here we identified AGK as a subunit of the mitochondrial TIM22 protein import complex. We show that AGK functions in a kinase-independent manner to maintain the integrity of the TIM22 complex, where it facilitates the import and assembly of mitochondrial carrier proteins...
August 3, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28705613/aging-related-effects-of-bed-rest-followed-by-eccentric-exercise-rehabilitation-on-skeletal-muscle-macrophages-and-insulin-sensitivity
#8
Paul T Reidy, Catherine C Lindsay, Alec I McKenzie, Christopher S Fry, Mark A Supiano, Robin L Marcus, Paul C LaStayo, Micah J Drummond
The pro- and anti-inflammatory macrophages are associated with insulin sensitivity and skeletal muscle regeneration. Infiltrating macrophages in skeletal muscle during a period of physical inactivity and subsequent reloading/rehabilitation in older adults is unknown, but may provide insight into mechanisms related to the development of metabolic disease and changes in muscle cell size. The purpose of this study was to determine if skeletal muscle macrophage infiltration is modulated differently between young and older adults after bed rest and exercise rehabilitation and if these responses are related to muscle and insulin sensitivity changes...
July 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28678054/exercise-training-prevents-dexamethasone-induced-rarefaction
#9
Naiara A Herrera, Isley Jesus, Evandro J Dionísio, Thiago J Dionísio, Carlos F Santos, Sandra L Amaral
Dexamethasone (DEX) causes rarefaction. In contrast, training (T) prevents rarefaction and stimulates angiogenesis. This study investigated the mechanisms responsible for the preventive role of T in DEX-induced rarefaction. Rats underwent T or were kept sedentary (8 weeks) and were treated with DEX or saline during the following 14 days. Tibialis anterior (TA) muscle was used for measurements of capillary density (CD), capillary-to-fiber ratio (C:F ratio), superoxide dismutase CuZn (SOD-1), superoxide dismutase MnSOD (SOD-2), catalase (CAT) mRNA as well as SOD-1, SOD-2, CAT, vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2 (VEGF-R2), cyclooxygenase-2 (COX-2), B-cell lymphoma 2 (Bcl-2), bcl-2-like protein 4 (Bax), p-Bax and caspase-3 cleaved protein levels...
May 17, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28677946/effects-of-probiotics-supplementation-and-circuit-training-on-immune-responses-among-sedentary-young-males
#10
Nur S Ibrahim, Foong K Ooi, Chee K Chen, Ayu S Muhamad
BACKGROUND: Growing evidence suggests that probiotics may have positive benefits on immune responses following endurance exercise. However, little attention has been given to its possible beneficial effects on immune responses following resistance exercise. METHODS: Forty-one healthy sedentary males were recruited and randomised into four groups: sedentary control with placebo (C), probiotics (P), circuit training with placebo (Ex), and circuit training with probiotics (PEx) groups...
July 5, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28664954/soft-skin-mounted-microfluidic-systems-for-measuring-secretory-fluidic-pressures-generated-at-the-surface-of-the-skin-by-eccrine-sweat-glands
#11
Jungil Choi, Yeguang Xue, Wei Xia, Tyler R Ray, Jonathan T Reeder, Amay J Bandodkar, Daeshik Kang, Shuai Xu, Yonggang Huang, John A Rogers
During periods of activity, sweat glands produce pressures associated with osmotic effects to drive liquid to the surface of the skin. The magnitudes of these pressures may provide insights into physiological health, the intensity of physical exertion, psychological stress factors and/other information of interest, yet they are currently unknown due to absence of means for non-invasive measurement. This paper introduces a thin, soft wearable microfluidic system that mounts onto the surface of the skin to enable precise and routine measurements of secretory fluidic pressures generated at the surface of the skin by eccrine sweat glands (surface SPSG, or s-SPSG) at nearly any location on the body...
July 25, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28654095/polygenic-risk-has-an-impact-on-the-structural-plasticity-of-hippocampal-subfields-during-aerobic-exercise-combined-with-cognitive-remediation-in-multi-episode-schizophrenia
#12
S Papiol, D Popovic, D Keeser, A Hasan, T Schneider-Axmann, F Degenhardt, M J Rossner, H Bickeböller, A Schmitt, P Falkai, B Malchow
Preliminary studies suggest that, besides improving cognition, aerobic exercise might increase hippocampal volume in schizophrenia patients; however, results are not consistent. Individual mechanisms of volume changes are unknown but might be connected to the load of risk genes. Genome-wide association studies have uncovered the polygenic architecture of schizophrenia. The secondary analysis presented here aimed to determine the modulatory role of schizophrenia polygenic risk scores (PRSs) on volume changes in the total hippocampus and cornu ammonis (CA) 1, CA2/3, CA4/dentate gyrus (DG) and subiculum over time...
June 27, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28646302/t-regulatory-cells-exhibit-a-biphasic-response-to-prolonged-endurance-exercise-in-humans
#13
Tom Clifford, Matthew J Wood, Philip Stocks, Glyn Howatson, Emma J Stevenson, Catharien M U Hilkens
PURPOSE: T-regulatory cells (Tregs) are a sub-population of lymphocytes that act to suppress aberrant immune responses. We investigated changes in the numbers of naïve and terminally differentiated Tregs in the peripheral blood to establish their role in the immuno-suppressive response to prolonged exercise. METHODS: Blood was drawn from seventeen experienced runners (age 40 ± 12 years; height 1.75 ± 0.08 m; mass 71.4 ± 10.8 kg) before, ~1 h after (POST-1h), and on the day following the marathon (POST-1d)...
August 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28630656/physical-activity-black-carbon-exposure-and-dna-methylation-in-the-foxp3-promoter
#14
Stephanie Lovinsky-Desir, Kyung Hwa Jung, Jacqueline R Jezioro, David Z Torrone, Mariangels de Planell-Saguer, Beizhan Yan, Frederica P Perera, Andrew G Rundle, Matthew S Perzanowski, Steven N Chillrud, Rachel L Miller
BACKGROUND: Physical activity is associated with improvement in lung function; however, pollution exposure during physical activity can lead to a transient reduction in lung function. This paradoxical relationship may be linked to altered T regulatory (Treg) cell activity, which increases with exercise and suppresses airway inflammation, but decreases in association with exposure to air pollution. To clarify these relationships, we investigated buccal cell DNA methylation of the forkhead box p3 (FOXP3) gene promoter, a proposed biomarker of Treg activity...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28620067/allele-specific-silencing-of-mutant-mrna-rescues-ultrastructural-and-arrhythmic-phenotype-in-mice-carriers-of-the-r4496c-mutation-in-the-ryanodine-receptor-gene-ryr2
#15
Rossana Bongianino, Marco Denegri, Andrea Mazzanti, Francesco Lodola, Alessandra Vollero, Simona Boncompagni, Silvia Fasciano, Giulia Rizzo, Damiano Mangione, Serena Barbaro, Alessia Di Fonso, Carlo Napolitano, Alberto Auricchio, Feliciano Protasi, Silvia G Priori
Rationale: Mutations in the cardiac Ryanodine Receptor gene (RYR2) cause dominant Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), a leading cause of sudden death in apparently healthy individuals exposed to emotions or physical exercise. Objective: We investigated the efficacy of allele specific silencing by RNA interference to prevent CPVT phenotypical manifestations in our dominant CPVT mice model carriers of the heterozygous mutation R4496C in RYR2Methods and Results: We developed an in vitro mRNA and protein-based assays to screen multiple siRNAs for their ability to selectively silence mutant RYR2-R4496C mRNA over the corresponding wild-type (WT) allele...
June 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28614774/new-insight-into-the-direct-anti-inflammatory-activity-of-a-myokine-irisin-against-proinflammatory-activation-of-adipocytes-implication-for-exercise-in-obesity
#16
A I Mazur-Bialy, J Bilski, E Pochec, T Brzozowski
A biological activity of myokine irisin, has been intensively investigated in the context of a browning process occurring in white adipose tissue, but its role as a modulator of immune response has been little studied. The aim of our study was to determine the impact of irisin (0 - 100 nM) on pro-inflammatory activation of adipocyte 3T3 L1 cell line. Irisin reduced in a concentration-dependent manner the expression and activity of major proinflammatory cytokines, e.g. tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) expression and their secretion into cell medium...
April 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28596299/postexercise-essential-amino-acid-supplementation-amplifies-skeletal-muscle-satellite-cell-proliferation-in-older-men-24%C3%A2-hours-postexercise
#17
Paul T Reidy, Christopher S Fry, Jared M Dickinson, Micah J Drummond, Blake B Rasmussen
Aged skeletal muscle has an attenuated and delayed ability to proliferate satellite cells in response to resistance exercise. The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is a focal point for cell growth, however, the effect of postexercise mTORC1 activation on human skeletal muscle satellite cell (SC) proliferation is unknown. To test the proliferative capacity of skeletal muscle SC in aging muscle to a potent mTORC1 activator (i.e., EAA; essential amino acids) we recruited older (~72y) men to conduct leg resistance exercise (8setsx10reps) without (-EAA; n = 8) and with (+EAA: n = 11) ingestion of 10 g of EAA 1 h postexercise...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28591984/-clinicopathologic-features-and-expression-of-oct4-protein-in-testicular-diffuse-large-b-cell-lymphoma
#18
Y P Chen, W F Zhu, L F Chen, J P Lu, T M He, W D Fu, C W Xu, G Chen
Objective: To evaluate the expression of OCT4 and SALL4 in testicular diffuse large B-cell lymphoma (DLBCL), and the utility of an immunohistochemical (IHC) panel of OCT4, SALL4 and CD20 in the differential diagnosis of DLBCL and GCT of the testis. Methods: Eighteen cases of testicular DLBCL were selected.IHC method was used to detect the protein expression of CD20, CD3, CD5, CD10, bcl-6, MUM1, Ki-67, bcl-2, c-MYC, OCT4 and SALL4. Results: Among the 18 cases, CD20 and PAX5 were strongly and diffusely expressed in all cases, while CD21, CD3, cyclinD1, SALL4, CD117 and PLAP were all negative...
June 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28568169/effect-of-dexamethasone-and-fluticasone-on-airway-hyperresponsiveness-in-horses-with-inflammatory-airway-disease
#19
R Léguillette, T Tohver, S L Bond, J A Nicol, K J McDonald
BACKGROUND: Airway hyperresponsiveness (AWHR), expressed as hypersensitivity (PC75 RL ) or hyperreactivity (slope of the histamine dose-response curve), is a feature of inflammatory airway disease (IAD) or mild equine asthma in horses. Glucocorticoids are used empirically to treat IAD. OBJECTIVES: To determine whether dexamethasone (DEX) (0.05 mg/kg IM q24h) and inhaled fluticasone (FLUT) (3,000 μg q12h) administered by inhalation are effective in decreasing AWHR, lung inflammation, and clinical signs in horses with IAD...
July 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28559456/can-exercise-suppress-tumour-growth-in-advanced-prostate-cancer-patients-with-sclerotic-bone-metastases-a-randomised-controlled-study-protocol-examining-feasibility-safety-and-efficacy
#20
Nicolas H Hart, Robert U Newton, Nigel A Spry, Dennis R Taaffe, Suzanne K Chambers, Kynan T Feeney, David J Joseph, Andrew D Redfern, Tom Ferguson, Daniel A Galvão
INTRODUCTION: Exercise may positively alter tumour biology through numerous modulatory and regulatory mechanisms in response to a variety of modes and dosages, evidenced in preclinical models to date. Specifically, localised and systemic biochemical alterations produced during and following exercise may suppress tumour formation, growth and distribution by virtue of altered epigenetics and endocrine-paracrine activity. Given the impressive ability of targeted mechanical loading to interfere with metastasis-driven tumour formation in human osteolytic tumour cells, it is of equal interest to determine whether a similar effect is observed in sclerotic tumour cells...
May 30, 2017: BMJ Open
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