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extraskeletal osteosarcoma

Laura E Selmic, Lynn R Griffin, Megan H Rector, Mary Lafferty, Roy Pool, Nicole P Ehrhart
A rare presentation of an extraskeletal osteosarcoma at a previous interscapular injection site in a dog is described. Treatment included surgical excision of the tumor followed by 6 rounds of intravenous carboplatin, oral toceranib, and cyclophosphamide. The dog survived for 20.5 months after diagnosis despite early development of pulmonary metastases.
September 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
Eric C Huang, Varand Ghazikhanian, Xiaohua Qian
Giant cell-rich osteosarcoma is a rare histologic variant of conventional osteosarcoma that affects mainly the extremities. Extraskeletal giant cell-rich osteosarcoma is therefore exceedingly rare. Here, we report the first case of this uncommon tumor involving the parotid gland in a 62-year-old male who presented with initial right jaw swelling. Radiologic work-up revealed a 6.2 cm mass involving the right parotid gland. Fine-needle aspiration cytology showed numerous multinucleated giant cells in a background of dyshesive epithelioid cells and rare clusters of spindle stromal cells, suspicious for malignancy...
August 26, 2016: Diagnostic Cytopathology
Gabriel T Faz, Mahmoud Eltorky, Bernard Karnath
BACKGROUND Extraskeletal osteosarcomas (ESOS) of the mediastinum are extremely rare and may present with concurrent nontuberculous mycobacteria infection. CASE REPORT We present the second documented case of high-grade anterior mediastinal extraskeletal osteosarcoma in a 59-year-old man with a history of treated, latent tuberculosis (TB). Sputum samples grew Mycoplasma avium complex and Mycobacterium fortuitum. Imaging showed a right-sided 7.6 cm mass with compression of the main bronchus. Subsequent biopsy with vimentin staining established the diagnosis of ESOS...
2016: American Journal of Case Reports
Lukas M Nystrom, Nickolas B Reimer, John D Reith, Mark T Scarborough, C Parker Gibbs
BACKGROUND: Extraskeletal osteosarcoma is a rare tumor with a poor prognosis. The purpose of this study is to examine the oncologic outcomes of this disease as they relate to surgical treatment and use of adjuvant therapies. METHODS: We retrospectively analyzed all patients treated at our institution for high-grade extraskeletal osteosarcoma of the limb or chest wall. We recorded demographic data, presenting stage, surgical margin, use of adjuvant chemotherapy or radiation, incidence of local recurrence, metastases, and death...
2016: Iowa Orthopaedic Journal
Gaurav P S Gahlot, Maitrayee Roy, Hemant Jain, Nihar Ranjan Dash, K S Madhusudhan, Vaishali Suri, Rajni Yadav, Prasenjit Das
No abstract text is available yet for this article.
October 2015: Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation
George Jour, Lu Wang, Sumit Middha, Ahmet Zehir, Wen Chen, Justyna Sadowska, John Healey, Narasimhan P Agaram, Lisa Choi, Khedoudja Nafa, Meera Hameed
Extraskeletal osteosarcoma (ESOSA) is a rare soft tissue neoplasm representing <5% of osteosarcomas and <1% of all soft-tissue sarcomas. Herein, we investigate the clinicopathological and molecular features of ESOSA and explore potential parameters that may affect outcome. Thirty-two cases were retrieved and histomorphology was reviewed. Clinical history and follow-up were obtained through electronic record review. DNA from formalin-fixed paraffin-embedded (FFPE) tissue was extracted and processed from 27 cases...
January 2016: Journal of Pathology. Clinical Research
Kwang-Hyun Choi, Ji Sook You, Joon Won Huh, Young-In Jeong, Min Soo Kim, Mihn Sook Jue, Hyang-Joon Park
No abstract text is available yet for this article.
August 2016: Annals of Dermatology
Hannah Copeland, Peter B Makdisi, Michael Duncan, Thomas C Wozniak, George Makdisi
A 69-year-old female with a history of a heart transplant 16 years prior, presented with a large left chest mass identified on fluoroscopy in the cardiac catheterization lab. The patient noted a 40 pound weight loss in one year. A chest X-ray (CXR) and chest computed tomography (CT) demonstrated a large complex cystic mass in the left chest. A CT guided aspiration was performed, and the cytology for the cyst fluid was negative for malignancy. The patient continued to have worsening shortness of breath, a repeat chest CT scan and magnetic resonance imaging (MRI) three months later, demonstrated a recurrence of the left pleural mass...
June 2016: Annals of Translational Medicine
Christopher Healy, Leonard B Kahn, Samuel Kenan
Extraskeletal osteosarcoma (ESOS) originating in the subcutaneous tissue is a rare occurrence, accounting for less than 10 % of ESOS cases. Osteosarcoma of extraskeletal origin accounts for approximately 2-4 % of all osteosarcomas, and 1 % of soft tissue sarcomas. We report a case of an 80-year-old female with an isolated primary subcutaneous tumor of the forearm. After imaging, surgical excision, and pathological analysis, the diagnosis of a subcutaneous osteosarcoma was made. This report documents the clinical and pathological findings of subcutaneous ESOS in this case, along with a review of previous cases of subcutaneous ESOS...
September 2016: Skeletal Radiology
Kaoru Sumida, Noriko Kobayashi, Atsushi Nambu, Masao Tago, Isao Shibuya, Masashi Kawamoto
Chondral tumors in soft tissue are referred to as soft-tissue chondromas or extraskeletal chondromas, or as synovial chondromatosis if they arise in synovial tissue. We report the case of a 29-year-old man with synovial chondromatosis, also called synovial osteochondromatosis, which appeared in a solitary and extra-articular form. On magnetic resonance imaging (MRI) and computed tomography, the central portion of the tumor showed similar characteristics to bone marrow, despite the absence of any connection to adjacent bone...
March 2016: Acta Radiologica Open
Tsuyoshi Ito, Yoshitaka Katoh, Yuko Shimada, Aya Ohnuma-Koyama, Naofumi Takahashi, Maki Kuwahara, Takanori Harada
Extraskeletal osteosarcoma is extremely rare in mice. This case report demonstrates a spontaneous murine extraskeletal osteosarcoma that exhibited various histological growth patterns in an ICR mouse. At necropsy, the tumor mass was located in the abdominal wall and was 45 × 30 × 25 mm in size. Histopathologically, the tumor showed the following four growth patterns: a solid pattern of polygonal cells embedded in an osteoid eosinophilic matrix with calcification, an irregular sheet pattern of short spindle cells accompanying some eosinophilic multinucleated cells, a fascicular pattern of spindle cells and a cystic pattern lined by short spindle cells...
January 2016: Journal of Toxicologic Pathology
Sharmila Thilagavathy Narayanan, Meena Kumari Gopalakrishnan, Shifa Seyed Ibrahim, Raasi Sankar
Osteosarcoma is the most common primary malignant bone tumour with a bimodal peak. But its extraskeletal variant is very rare. It arises exclusively in soft tissue without at any skeletal attachment. It accounts for 2% of all soft tissue sarcomas. It is usually diagnosed as an incidental finding during imaging. Here, we are presenting a case of extraskeletal osteosarcoma diagnosed incidentally during imaging in a 30 years old male for its rarity.
January 2016: Journal of Clinical and Diagnostic Research: JCDR
Dana L Casey, Matt van de Rijn, Geoffrey Riley, Ka-Wah Tung, David G Mohler, Sarah S Donaldson
BACKGROUND: Extraskeletal osteosarcoma of the hand is rare, and its optimal modality of local control is not currently known. METHODS: A literature search was performed to identify studies that describe the treatment and outcomes of extraskeletal osteosarcoma. A second literature search was performed to identify studies that describe the treatment and outcomes of extraskeletal osteosarcoma of the hand specifically. RESULTS: The role of adjuvant radiation for extraskeletal osteosarcoma is not well defined...
December 2015: Hand: Official Journal of the American Association for Hand Surgery
Riyam T Zreik, Reid G Meyer, Robert B Jenkins, Germán A Norambuena, Karen J Fritchie
Primary extraskeletal osteosarcoma is an exceedingly rare malignant neoplasm that accounts for approximately 1% of soft tissue sarcomas and most often occurs in the deep soft tissues of adults. Extraskeletal osteosarcoma is characterized by the production of osteoid, bone, and/or chondroid matrix. The diagnosis of extraskeletal osteosarcoma requires careful radiologic and clinical correlation to ensure that the patient does not have an underlying bone primary. This is a case report of primary subcutaneous extraskeletal osteosarcoma arising in the thigh of a 15-year-old girl with a complex karyotype, and the morphologic differential diagnosis is reviewed...
April 2016: American Journal of Dermatopathology
Jennifer E Slovak, Nina R Kieves, Joseph Haynes
An 8 yr old spayed female Italian greyhound was presented with a mass in the cranial abdomen. Preliminary evaluation of the dog revealed a large, cavitary, irregularly shaped mass with no definitive association with any abdominal organs. During an exploratory celiotomy, a 16 cm × 12 cm × 6 cm mass was removed. On subsequent histopathology, extraskeletal osteosarcoma induced by a foreign body granuloma was diagnosed. The foreign body granuloma, based on histopathological findings, was suspected to be secondary to a retained surgical sponge from her routine ovariohysterectomy performed 7 yr prior to presentation...
September 2015: Journal of the American Animal Hospital Association
Eva M T Bots, Pieter J Wismans, Lennert Slobbe
No abstract text is available yet for this article.
January 2016: Thorax
Y Asenov, B Stefanov, B Korukov, V Tihtchev, V Hadzhiysca, D Damianov
For the first time extraskeletal osteosarcomas (ESOS) were described by Wilson in 1941. They are extremely rare neoplasms, presenting 4% of all osteosarcomas and 1,2% of all soft-tissue sarcomas. About 300 cases have been reported in the literature up to date. We present a 66-year-old female patient, admitted in the clinic because of acute bleeding in retroperitoneal space. Revision of the retroperitoneal space and haemostasis were performed. The patient was re-operated because postoperative bowel obstruction...
July 2015: Chirurgia
Max Wohlauer, Jesse K McKenney, Woosup Michael Park
BACKGROUND: A 68-year-old woman with a thoracoabdominal aortic aneurysm recently status after first-stage elephant trunk procedure with right brachiocephalic artery endarterectomy and reimplantation of the innominate and left carotid using a 14 × 10-mm branch graft presented to clinic with increasing pain in her right arm and shoulder for 2 weeks. She also had a remote history of radiation to the right axilla for breast cancer. On physical examination, she had a tender mass under her clavicle, numbness in shoulder and right hand weakness...
January 2016: Annals of Vascular Surgery
Sabino Strippoli, Michele Traversa, Antonio Cramarossa, Ondina Popescu, Vito Lorusso, Michele Guida
Extraskeletal osteosarcomas (EOSs) are rare variants of primary osteosarcoma of the bone, and are defined as sarcomas located in the soft tissues and characterized by osteoid production. EOS exhibits distinctive demographic, imaging and prognostic features compared with osteosarcoma of bone origin. The available data are contradictory with regard to the use of chemotherapy regimens in the management of EOS. The present study describes a case of EOS that progressed following two lines of therapy oriented to soft-tissue and bone sarcoma histology, respectively...
June 2015: Oncology Letters
Abhishek Shankar, Ranjit Kumar Sahoo, Abhidha Malik, Aanchal Kakkar, Goura Kishor Rath
Extraskeletal osteosarcoma is a rare malignant soft tissue tumor. At open cholecystectomy performed for gallstones, a 45-year-old woman was found to have extraskeletal osteosarcoma on histopathological examination. 1 year after surgery, the patient is symptom free and all imaging studies are normal. After multidisciplinary discussion it was decided to give no further treatment. The patient was asked to follow up three monthly. Although osteosarcoma has rarely been reported at other extraskeletal sites, this appears to be the third case of a primary tumor in the gallbladder...
December 2015: Journal of the Egyptian National Cancer Institute
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