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extraskeletal osteosarcoma

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https://www.readbyqxmd.com/read/29502131/clinical-radiological-and-pathological-features-of-extraskeletal-osteosarcoma
#1
Lauren A Roller, Ivan Chebib, Miriam A Bredella, Connie Y Chang
OBJECTIVE: To evaluate clinical and radiological features of pathology-proven extraskeletal osteosarcomas. METHODS: This retrospective study was IRB-approved and HIPAA-compliant. Our pathology database was queried for cases of extraskeletal osteosarcoma. Tumor location, size, imaging appearance, presence of metastases, and clinical outcome were documented. RESULTS: Nineteen patients met inclusion criteria (age 59 ± 15 (range 28-85) years; 15 male, 4 female)...
March 3, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29489027/extraskeletal-osteosarcoma-mdm2-and-h3k27me3-analysis-of-19-cases-suggest-disease-heterogeneity
#2
Naohiro Makise, Masaya Sekimizu, Takashi Kubo, Susumu Wakai, Shun-Ichi Watanabe, Tomoyasu Kato, Takayuki Kinoshita, Nobuyoshi Hiraoka, Masashi Fukayama, Akira Kawai, Hitoshi Ichikawa, Akihiko Yoshida
AIMS: Extraskeletal osteosarcoma (ESOS) is a sarcoma in the non-skeletal tissue that directly produces neoplastic osteoid or bone. Dedifferentiated liposarcoma (DDLPS) and malignant peripheral nerve sheath tumor (MPNST) are the two most common types of sarcoma that can harbor heterologous osteosarcomatous differentiation. We aimed to determine the potential relationship of ESOS to DDLPS and MPNST. METHODS AND RESULTS: We investigated MDM2 and H3K27me3 status in 19 cases of ESOS, 2 of which contained a low-grade component...
February 28, 2018: Histopathology
https://www.readbyqxmd.com/read/29399350/extraskeletal-osteosarcoma-of-the-lung-following-treatment-of-primary-small-cell-lung-carcinoma-with-chemoradiotherapy-a-case-report
#3
Kei Takamura, Takahiro Ogi, Makoto Yamamoto, Keisuke Kikuchi
Primary pulmonary osteosarcoma is a rare entity, with only a few cases reported in the literature to date. Moreover, secondary extraskeletal osteosarcoma of the lung following chemoradiotherapy is extremely rare and, to the best of our knowledge, this is the first reported case. We herein present the case of an 80-year-old male patient with small-cell lung cancer (SCLC), who developed what it was initially considered as recurrence of the tumor after chemoradiotherapy. The patient eventually succumbed to the disease, and on autopsy it was discovered that the lung tumor was not in fact SCLC, but rather a secondary osteosarcoma...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29312772/primary-thoracic-extraskeletal-osteosarcoma-a-case-report-and-literature-review
#4
Jie Qian, Xue-Yan Zhang, Ping Gu, Jin-Chen Shao, Bao-Hui Han, Hui-Min Wang
Primary extraskeletal osteosarcoma (ESOS) presenting in thoracic locations is very rare and associated with a poor prognosis. The current study presents a case involving a large anterior mediastinal mass, which was histologically confirmed as a primary osteosarcoma. The literature concerning primary thoracic ESOS is reviewed. A total of 60 cases were identified. The median age was 60 years (range, 14-93 years) and males were more prevalent among the reported cases (65%). Survival analysis revealed that the overall 5-year survival was only 22...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29032283/extraskeletal-osteosarcoma-of-the-hand
#5
Ross M Dunbar, Gonzalo E Sumarriva, Scott F M Duncan, John D Reith, Mark S Meyer
Extraskeletal osteosarcoma is a rare disease that uncommonly affects the upper extremity. A 46-year-old African American man presented for evaluation of a right middle finger mass. Excisional biopsy demonstrated extraskeletal osteosarcoma of the soft tissues. We performed a transmetacarpal ray resection.
October 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28947094/extraskeletal-osteosarcoma-in-the-parotid-gland-a-case-report
#6
Takao Hamamoto, Takashi Kono, Hiromi Furuie, Tsutomu Ueda, Sachio Takeno, Katsuhiro Hirakawa, Koji Arihiro
Extraskeletal osteosarcoma is a very rare tumor and accounts for 4-5% of all osteosarcomas. We describe a 47-year-old Japanese man who presented with a right parotid tumor. The patient underwent total resection with postoperative radiotherapy; however, the tumor recurred in the lung, whereupon he underwent chemotherapy and partial lung resection. After surgery, a hemorrhagic brain metastasis appeared; this tumor was extirpated to prevent bleeding into the brain, after which additional chemotherapy was administered...
September 22, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28749294/osteosarcoma-in-african-hedgehogs-atelerix-albiventris-five-cases
#7
Alonso Reyes-Matute, Adriana Méndez-Bernal, Liliana-Aurora Ramos-Garduño
Osteosarcomas are unusual neoplasms in African hedgehogs ( Atelerix albiventris ) and have been reported in extraskeletal and skeletal locations, including mandible, ribs, and vertebra. Five hedgehogs with osteosarcoma submitted to the Pathology Department at Facultad de Medicina Veterinaria y Zootecnia, National Autonomous University of Mexico are reported. In two cases, the neoplasm arose from the skull; one case arose from the ribs with associated compression of the thoracic and abdominal cavity, and another case involved the vertebrae...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28666052/rare-dual-lesion-extraskeletal-osteosarcoma-developing-within-a-simple-lipoma
#8
Jonathan Tresley, Ross Wodicka, Andrew Rosenberg, John D Pitcher, Ty K Subhawong
Extraosseous osteosarcoma is a rare malignancy, but simple lipomas are common. This article is the first report of a case of radiation-induced extraosseous osteosarcoma that developed within a simple lipoma in a 72-year-old woman. We correlate the magnetic resonance imaging, computed tomography, positron emission tomography, and plain radiographic findings. The patient, treated with systemic therapy and wide surgical resection of the neoplasm, remained clinically free of disease during the first 22 months of follow-up...
May 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28645924/anterior-abdominal-wall-extraosseous-osteosarcoma-occurring-40-years-after-para-aortic-irradiation
#9
Muhammad Furrukh, Asim Qureshi, Nadira Mamoon, Menahil Fatima
Extraskeletal osteosarcomas (OSs) are highly malignant soft tissue tumours associated with a poor prognosis. Only a few records of these rare aggressive neoplasms have been reported in the literature.We describe the case of a 49-year-old man, who presented to our tertiary care centre with a painful isolated lump around the umbilicus. After surgical biopsy, imaging and subsequent pathological analysis, the swelling was diagnosed to be a localised extraskeletal OS. He received previous radiation as treatment for testicular seminoma 40 years ago, which has been in remission ever since...
June 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28633587/sarcomatoid-carcinoma-manifesting-as-recurrent-rectal-cancer-and-mimicking-radiation-induced-extraskeletal-osteosarcoma-a-case-report
#10
MiJo Lee, Hyun-Jin Son, Je-Ho Jang, Hyun-Young Han, Moon Hyang Park
Here, we report an unusual case of sarcomatoid carcinoma mimicking extraskeletal osteosarcoma that manifested as recurrent rectal cancer. Five years earlier, a 76-year-old male patient had undergone neoadjuvant chemoradiotherapy followed by a laparoscopic low anterior resection due to adenocarcinoma of the rectum. He was admitted because of pain in the anus and left hip. He underwent abdominal computed tomography that revealed a newly developed left perirectal mass with gluteus maximus invasion measuring up to 8 cm, and therefore, an abdominoperineal resection was performed...
June 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28627100/subcutaneous-extraskeletal-osteosarcoma-in-a-metatarsal-footpad-in-a-cat
#11
Ramón Almela, Wolf von Bomhard, Agustina Ansón, Ursula Mayer
BACKGROUND: Extraskeletal osteosarcomas (ESOSAs) are rare neoplasms in humans and animals. In cats, ESOSA has been reported to arise from orbital, ocular, intestinal, mammary and subcutaneous locations. Subcutaneous ESOSA occurs most commonly at sites used for vaccination including interscapular, dorsal lumbar or thigh areas. Previous reports of feline cases have not documented the use of advanced diagnostic imaging to exclude a primary bone tumour. OBJECTIVE: To describe the clinicopathological and advanced imaging findings of a subcutaneous ESOSA occurring in a metatarsal footpad of a cat and to report the one year follow-up status...
June 18, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28623518/primary-intraventricular-osteosarcoma-in-a-3-year-old-boy-report-of-a-case-and-review-of-literature
#12
Ahmad Pourrashidi Boshrabadi, Mohammadali Surakiazad, Kourosh Karimi Yarandi, Abbas Amirjamshidi
INTRODUCTION: Extraskeletal osteosarcoma (ExOS) is a rare and well-known entity. Three to 4% of ExOSs occur in the head and neck region but anecdotally in the central nervous system (CNS). Primary intracranial osteosarcoma (PIOS) can originate from the skull, brain parenchyma, or meninges. CASE PRESENTATION: A 3-year-old boy with history of head trauma 2 weeks before admission is presented harboring an ExOS in the left temporoparietal region. He was operated with the impression of intraventricular meningioma but turned to be a PIOS without any sources in his skeleton...
August 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28622153/extraskeletal-osteosarcoma-outcomes-and-the-role-of-chemotherapy
#13
Jonas Paludo, Karen Fritchie, Candace L Haddox, Peter S Rose, Carola A S Arndt, Randolph S Marks, Evanthia Galanis, Scott H Okuno, Steven I Robinson
OBJECTIVES: Extraskeletal osteosarcoma (EO) is a malignant neoplasm that produces osteoid, bone, and chondroid material without direct attachment to bone or periosteum. Surgical resection is the mainstay of treatment; the role of chemotherapy is not well defined. Therefore, we evaluated the impact of chemotherapy in the survival of patients with EO. METHODS: All EO patients seen at Mayo Clinic between 1990 and 2014 were assessed. Forty-three patients were included after all archived pathology slides were reviewed to confirm the diagnosis of EO...
June 15, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28551716/extraskeletal-osteosarcoma-arising-from-the-pleura
#14
Cristian Rapicetta, Filippo Lococo, Gabriele Carlinfante, Tommaso Ricchetti, Massimiliano Paci
No abstract text is available yet for this article.
August 2017: Lung
https://www.readbyqxmd.com/read/28536749/extraskeletal-osteosarcoma-arising-in-myositis-ossificans-a-case-report-and-review-of-the-literature
#15
REVIEW
Deepika Savant, Shachar Kenan, Samuel Kenan, Leonard Kahn
We report a case of a 23-year-old female with pain and fullness in the right popliteal fossa. An MRI scan demonstrated an ossified enhancing soft tissue mass. Evaluation of the resected specimen showed a high-grade extraskeletal osteosarcoma juxtaposed to the three zones of myositis ossificans. At 1-year follow-up the patient is alive and disease free. A review of the literature purporting to document such an association failed to demonstrate a single case in which an osteosarcoma and MO with its zonal architecture co-existed...
August 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28434377/a-primary-extraskeletal-osteosarcoma-of-the-mesentery-a-case-report
#16
Nathalie E J van den Broek, Paul Willemsen, Caroline Mattelaer
Extraskeletal osteosarcoma is a rare and invasive malignancy, typically located in the soft tissue without attachment to the skeleton. The present study reports a case of a primary mesenteric extraskeletal osteosarcoma of a 71-year-old woman. The patient complained of an incomplete defecation. Colonoscopy showed an ulcer with impression of external compression of the sigmoid. An additional abdominal computed tomography (CT) scan revealed a large, almost completely calcified, mass in the left lower abdomen causing hydronephrosis of the left kidney...
April 24, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28384952/a-case-report-on-extraskeletal-osteosarcoma
#17
Vivek Verma, Ashish Gulia, Ajay Puri
No abstract text is available yet for this article.
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28335813/tumor-lysis-syndrome-in-an-extraskeletal-osteosarcoma-a-case-report-and-review-of-the-literature
#18
REVIEW
Vito Emanuele Catania, Michele Vecchio, Michele Malaguarnera, Roberto Madeddu, Giulia Malaguarnera, Saverio Latteri
BACKGROUND: This case report describes a spontaneous tumor lysis syndrome due to a rare solid tumor. CASE PRESENTATION: A 65-year-old white woman had tumor lysis syndrome, which represent a dangerous oncological emergency. This syndrome occurs usually with a hematological tumor, but in this case our patient had a solid tumor, which was a rare extraskeletal osteosarcoma, localized in her pelvic region. She also had lung metastases and bilateral hydronephrosis. After spontaneous tumor lysis syndrome, she had acute renal insufficiency, which was treated with hemodialysis and successively with rasburicase, Kayexalate (sodium polystyrene sulfonate), and febuxostat...
March 24, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28289512/giant-abdominal-osteosarcoma-causing-intestinal-obstruction-treated-with-resection-and-adjuvant-chemotherapy
#19
Alexandros Diamantis, Grigorios Christodoulidis, Dionysia Vasdeki, Foteini Karasavvidou, Evangelos Margonis, Konstantinos Tepetes
Extraskeletal osteosarcoma (ESOS) is an uncommon tumor that accounts for 1% of all soft tissue sarcomas and 4% of all osteosarcomas. Its presentation may be atypical, while pain has been described as the most common symptom. Radiological findings include a large mass in the soft-tissues with massive calcifications, but no attachment to the adjacent bone or periosteum. We present the case of a 73-year-old gentle man who presented with a palpable, tender abdominal mass and symptoms of bowel obstruction. Computer tomography images revealed a large space-occupying heterogeneous, hyper dense soft tissue mass involving the small intestine...
February 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28235629/primary-extraskeletal-osteosarcoma-a-clinicopathological-study-of-18-cases-focusing-on-mdm2-amplification-status
#20
Kyoko Yamashita, Kenichi Kohashi, Yuichi Yamada, Yoshihiro Nishida, Hiroshi Urakawa, Yoshinao Oda, Shinya Toyokuni
Extraskeletal osteosarcoma (ESOS) is an uncommon malignant neoplasm. Most ESOSs are high grade, although some low-grade cases have been reported. A few cases of ESOS with MDM2 amplification have also been reported, suggesting some similarity to skeletal low-grade osteosarcoma such as parosteal osteosarcoma, where MDM2 is often amplified. However, the frequency of low-grade cases and cases with MDM2 amplification among ESOSs remains unknown, and their relationship is unclear. To clarify this, we examined 18 primary ESOS cases clinically, pathologically, and genetically, focusing on their MDM2 amplification status...
May 2017: Human Pathology
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