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https://www.readbyqxmd.com/read/29141686/anisotropic-m%C3%A3-ller-glial-scaffolding-supports-a-multiplex-lattice-mosaic-of-photoreceptors-in-zebrafish-retina
#1
Mikiko Nagashima, Jeremy Hadidjojo, Linda K Barthel, David K Lubensky, Pamela A Raymond
BACKGROUND: The multiplex, lattice mosaic of cone photoreceptors in the adult fish retina is a compelling example of a highly ordered epithelial cell pattern, with single cell width rows and columns of cones and precisely defined neighbor relationships among different cone types. Cellular mechanisms patterning this multiplex mosaic are not understood. Physical models can provide new insights into fundamental mechanisms of biological patterning. In earlier work, we developed a mathematical model of photoreceptor cell packing in the zebrafish retina, which predicted that anisotropic mechanical tension in the retinal epithelium orients planar polarized adhesive interfaces to align the columns as cone photoreceptors are generated at the retinal margin during post-embryonic growth...
November 15, 2017: Neural Development
https://www.readbyqxmd.com/read/29140826/effects-of-integrating-rhythmic-arm-swing-into-robot-assisted-walking-in-patients-with-subacute-stroke-a-randomized-controlled-pilot-study
#2
Tae-Woo Kang, Duck-Won Oh, Ji-Hyun Lee, Heon-Seock Cynn
This study aimed to identify the effects of rhythmic arm swing during robot-assisted walking training on balance, gait, motor function, and activities of daily living among patients with subacute stroke. Twenty patients with subacute stroke were recruited, and thereafter randomly allocated to either the experimental group that performed the robot-assisted walking training with rhythmic arm swing, or the control group that performed the training in arm fixation. In total, 30 training sessions were carried out...
November 14, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29137615/advance-directives-proxy-opinions-and-treatment-restrictions-in-patients-with-severe-stroke
#3
Floor A S de Kort, Marjolein Geurts, Paul L M de Kort, Julia H van Tuijl, Ghislaine J M W van Thiel, L Jaap Kappelle, H Bart van der Worp
BACKGROUND: Patients with severe stroke often do not have the capacity to participate in discussions on treatment restrictions because of a reduced level of consciousness, aphasia, or another cognitive disorder. We assessed the role of advance directives and proxy opinions in the decision-making process of incapacitated patients. METHODS: Sixty patients with severe functional dependence (Barthel Index ≤6) at day four after ischemic stroke or intracerebral hemorrhage were included in a prospective two-center cohort study...
November 14, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/29130705/disability-and-its-influence-in-nutritional-assessment-tools-in-elderly-people-living-in-nursing-homes
#4
Beatriz Lardiés-Sánchez, Alejandro Sanz-París, Javier Pérez-Nogueras, Antonio Serrano-Oliver, María Elena Torres-Anoro, María Dolores Ballesteros-Pomar
INTRODUCTION: Poor nutritional status is associated with increased morbidity and mortality, especially in older people. OBJECTIVE: The aim of this study was to assess nutritional status in elderly nursing home residents with different nutritional test, and to determine which parameters used for nutritional assessment can be carried out in this population, which usually have a high prevalence of functionally dependent residents. METHODS: A cross-sectional study was performed in 383 elderly...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29127079/effect-of-acupuncture-and-chinese-herbal-medicine-on-subacute-stroke-outcomes-a-single-centre-randomised-controlled-trial
#5
Jianqiao Fang, Crystal Lynn Keeler, Lifang Chen, Ruijie Ma, Chao Wang, Shouyu Xu
OBJECTIVE: To determine whether integrative medicine, combining acupuncture and Chinese herbal medicine with conventional rehabilitation during subacute stroke, is an effective comprehensive rehabilitation strategy for daily life activities, neurological deficits, motor dysfunction, cognitive impairment and depression. DESIGN: Randomised controlled trial: patients were randomly assigned to a conventional rehabilitation (CR) group or an integrative medicine rehabilitation (IMR) group with CR plus acupuncture and Chinese herbal medicine...
November 10, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29125861/identification-of-hospitalized-elderly-patients-at-risk-for-adverse-in-hospital-outcomes-in-a-university-orthopedics-and-trauma-surgery-environment
#6
Janine Gronewold, Christian Dahlmann, Marcus Jäger, Dirk M Hermann
BACKGROUND: As a consequence of demographic changes, hospitals are confronted with increasing numbers of elderly patients, who are at high risk of adverse events during hospitalization. Geriatric risk screening followed by comprehensive geriatric assessment (CGA) and treatment has been requested by geriatric societies and task forces to identify patients at risk. Since empirical evidence on factors predisposing to adverse hospital events is scarce, we now prospectively evaluated implications of geriatric risk screening followed by CGA in a university hospital department of orthopedics and trauma surgery...
2017: PloS One
https://www.readbyqxmd.com/read/29122267/effects-of-traditional-chinese-exercises-on-the-rehabilitation-of-limb-function-among-stroke-patients-a-systematic-review-and-meta-analysis
#7
REVIEW
Li Ge, Qing-Xiang Zheng, Yan-Tan Liao, Jing-Yu Tan, Qiu-Lin Xie, Mikael Rask
OBJECTIVE: To systematically review literature about the rehabilitative effects of traditional Chinese exercises (TCEs) on limb function among patients with stroke. METHODS: Systematic review and meta-analysis of randomized controlled trials (RCTs). Twelve electronic databases were searched from their inceptions to February 2017, including PudMed, The Cochrane Library, Web of Science, EMBase, Science Direct, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine, Chinese Scientific Journal Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database and WanFang Data...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29121638/impact-of-inability-to-turn-in-bed-assessed-by-a-wearable-three-axis-accelerometer-on-patients-with-parkinson-s-disease
#8
Kenji Uchino, Makoto Shiraishi, Keita Tanaka, Masashi Akamatsu, Yasuhiro Hasegawa
BACKGROUND: Difficulty turning over in bed is a common night-time symptom in Parkinson's disease (PD). We aimed to quantitatively evaluate overnight turnover movements using a three-axis accelerometer and to investigate whether inability to turn in bed is related to daytime sleepiness, sleep quality, and depressive mood in PD patients. METHODS: We examined 64 patients with PD (mean age, 73.3±8.21 years; modified Hoehn-Yahr [mH-Y] stage, 3.0±1.0; disease duration, 7...
2017: PloS One
https://www.readbyqxmd.com/read/29116209/preoperative-n-terminal-pro-b-type-natriuretic-peptide-concertation-and-prognosis-of-brain-tumor-patients-a-5-year-follow-up-study
#9
Adomas Bunevicius, Vytenis Deltuva, Edward R Laws, Giorgio Iervasi, Arimantas Tamsauskas, Robertas Bunevicius
Increased N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration predicts poor prognosis of non-CNS cancer patients. We evaluated the association of NT-proBNP concentration with disease severity, discharge outcomes and prognosis of patients undergoing craniotomy for brain tumor. From January, 2010 until September, 2011 two-hundred and forty-five patients (age 55.05 ± 14.62 years) admitted for brain tumor surgery were evaluated for NT-proBNP serum concentration. Outcome at hospital discharge was evaluated with the Glasgow Outcome Scale (GOS)...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115367/bahng-score-predictive-model-for-detection-of-subjects-with-the-oropharynx-colonized-by-uncommon-microorganisms
#10
J González-Del Castillo, J Teja-Marina, F J Candel, J Barberán, A Moreno-Cuervo, F Chiarella, L López-González, P Ramos-Cordero, F J Martín-Sánchez
OBJECTIVE: Pneumonia is most frequently produced by the microaspiration of flora that colonizes the oropharynx. Etiological diagnosis of pneumonia is infrequent in clinical practise and empirical treatment should be prescribed. The aims of the present study were to determine the factors associated with oropharynx colonization by uncommon microorganisms (UM) and to develop a predictive model. METHODS: A cross-sectional study that included all pa-tients living in one long-term care facilities was developed...
November 6, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29110087/outcomes-of-open-versus-laparoscopic-surgery-in-patients-with-rectal-cancer
#11
José M Quintana, Ane Anton-Ladislao, Santiago Lázaro, Nerea Gonzalez, Marisa Bare, Nerea Fernandez de Larrea, Maximino Redondo, Eduardo Briones, Antonio Escobar, Cristina Sarasqueta, Susana Garcia-Gutierrez
PURPOSE: The goal of this study was to compare the effectiveness of laparoscopic with that of open surgery up to 2 years after intervention in patients with rectal cancer. METHODS: This is a prospective cohort study of patients with rectal cancer who underwent surgery (laparoscopic or open) between June 2010 and December 2012 in 22 acute hospitals. Main outcomes were mortality, complications, reoperation, readmission, and patient-reported outcome measures (PROMs), as measured using the EuroQol-5D (EQ-5D), European Organisation for Research and Treatment of Cancer (EORTC) QLQ-Q30 and Q29, the Barthel Index (BI), and the Duke-UNC Functional Social Support Questionnaire at baseline, 1 year, and 2 years after surgery...
November 6, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29107975/trajectories-of-maternal-ante-and-postpartum-depressive-symptoms-and-their-association-with-child-and-mother-related-characteristics-in-a-west-african-birth-cohort-study
#12
Dana Barthel, Levente Kriston, Daniel Fordjour, Yasmin Mohammed, Esther Doris Kra-Yao, Carine Esther Bony Kotchi, Ekissi Jean Koffi Armel, Kirsten Alexandra Eberhardt, Torsten Feldt, Rebecca Hinz, Koffi Mathurin, Stefanie Schoppen, Carola Bindt, Stephan Ehrhardt
BACKGROUND: The vast majority of research on mental health has been undertaken in high income countries. This study aimed at investigating the long-term course of maternal depressive symptoms and its association with various mother- and child-related characteristics in two West African lower middle income countries with focus on the relationship with long-term anxiety symptoms. METHODS: In the Child Development Study, a prospective birth cohort study in Côte d'Ivoire and Ghana, the 9-item Patient Health Questionnaire (PHQ-9) was answered by N = 776 women 3 months antepartum, and 3, 12, and 24 months postpartum between April 2010 and March 2014...
2017: PloS One
https://www.readbyqxmd.com/read/29107039/perceived-participation-and-its-correlates-among-first-stroke-survivors-at-six-months-after-discharge-from-a-tertiary-hospital-in-china
#13
Xuemei Chen, Yanan He, Xianmei Meng, Chenchen Gao, Zhihui Liu, Lanshu Zhou
OBJECTIVES: To describe perceived participation of first-stroke survivors in mainland China, and to determine variables that may correlate with perceived participation six months after discharge. DESIGN: Cross-sectional survey. SETTING: Neurology department of a tertiary hospital in Shanghai, China, with subsequent follow-up of patients in their homes. SUBJECTS: Two hundred and thirty-six first-stroke survivors who had been treated in the neurology department and discharged six months prior to their participation in our study...
October 26, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29106527/bedside-autonomic-risk-stratification-after-myocardial-infarction-by-means-of-short-term-deceleration-capacity-of-heart-rate
#14
Konstantinos D Rizas, Christian Eick, Angela J Doller, Wolfgang Hamm, Lukas von Stuelpnagel, Christine S Zuern, Petra Barthel, Georg Schmidt, Axel Bauer
Aims: Twenty-four-hour deceleration capacity (DC24h) of heart rate is a strong predictor of mortality after myocardial infarction (MI). Assessment of DC from short-term recordings (DCst) would be of practical use in everyday clinical practice but its predictive value is unknown. Here, we test the usefulness of DCst for autonomic bedside risk stratification after MI. Methods and results: We included 908 patients after acute MI enrolled in Munich and 478 patients with acute (n = 232) and chronic MI (n = 246) enrolled in Tuebingen, both in Germany...
June 30, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29099951/tumorfusions-an-integrative-resource-for-cancer-associated-transcript-fusions
#15
Xin Hu, Qianghu Wang, Ming Tang, Floris Barthel, Samirkumar Amin, Kosuke Yoshihara, Frederick M Lang, Emmanuel Martinez-Ledesma, Soo Hyun Lee, Siyuan Zheng, Roel G W Verhaak
Gene fusion represents a class of molecular aberrations in cancer and has been exploited for therapeutic purposes. In this paper we describe TumorFusions, a data portal that catalogues 20 731 gene fusions detected in 9966 well characterized cancer samples and 648 normal specimens from The Cancer Genome Atlas (TCGA). The portal spans 33 cancer types in TCGA. Fusion transcripts were identified via a uniform pipeline, including filtering against a list of 3838 transcript fusions detected in a panel of 648 non-neoplastic samples...
November 1, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29099301/analysis-of-overlapping-surgery-in-patients-undergoing-microsurgical-aneurysm-clipping-acute-and-long-term-outcomes-from-the-barrow-ruptured-aneurysm-trial
#16
Michael A Mooney, Scott Brigeman, Michael A Bohl, Elias D Simon, John P Sheehy, Steve W Chang, Robert F Spetzler
OBJECTIVE Overlapping surgery is a controversial subject in medicine today; however, few studies have examined the outcomes of this practice. The authors analyzed outcomes of patients with acutely ruptured saccular aneurysms who were treated with microsurgical clipping in a prospectively collected database from the Barrow Ruptured Aneurysm Trial. Acute and long-term outcomes for overlapping versus nonoverlapping cases were compared. METHODS During the study period, 241 patients with ruptured saccular aneurysms underwent microsurgical clipping...
November 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29092990/multiple-limb-salvage-attempts-for-diabetic-foot-infections-is-it-worth-it
#17
C C Hong, J H Tan, S H Lim, A Nather
AIMS: Limb salvage for diabetic foot infections often require multiple procedures. Some patients will eventually end up with below knee amputation (BKA) when all limb salvage attempts fail. We seek to study the patients' ability to return to normal life, functional status, prosthesis usage and perspectives on multiple limb salvage procedures that culminated in BKA to review if they would undertake a similar path if their situation was repeated. PATIENTS AND METHODS: A total of 41 patients who underwent BKA between July 2011 and June 2013 were reviewed...
November 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29089989/constraint-induced-movement-therapy-in-treatment-of-acute-and-sub-acute-stroke-a-meta-analysis-of-16-randomized-controlled-trials
#18
Xi-Hua Liu, Juan Huai, Jie Gao, Yang Zhang, Shou-Wei Yue
OBJECTIVE: The aim of this meta-analysis was to evaluate the clinical efficacy of constraint-induced movement therapy in acute and sub-acute stroke. DATA SOURCES: The key words were stroke, cerebrovascular accident, constraint-induced therapy, forced use, and randomized controlled trial. The databases, including China National Knowledge Infrastructure, WanFang, Weipu Information Resources System, Chinese Biomedical Literature Database, PubMed, Medline, Embase, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews, were searched for studies on randomized controlled trials for treating acute or sub-acute stroke published before March 2016...
September 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29077985/the-experience-of-psychological-distress-in-family-caregivers-of-people-with-dementia-a-cross-sectional-study
#19
Wilson Abreu, Teresa Rodrigues, Carlos Sequeira, Regina Pires, Ana Sanhudo
PURPOSE: To evaluate the degree of psychological distress in family caregivers of people with dementia. DESIGN AND METHODS: A nonprobabilistic sample of 54 dyads (people with dementia and family caregivers) was recruited. A sociodemographic questionnaire, the Brief Symptom Inventory (BSI), and the Barthel Index were used for data collection. FINDINGS: About half of the caregivers had significant levels of psychological distress. Caregivers showed high scores in some BSI dimensions: somatization, obsessive-compulsion, interpersonal sensitivity, anxiety, and paranoid ideation...
October 27, 2017: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/29077289/-predictors-of-drug-resistant-pathogens-in-community-onset-pneumonia-are-factors-considered-in-health-care-associated-pneumonia-useful-in-the-emergency-department
#20
Olga H Torres Bonafonte, Eva Gil Olivas, Estefanía Pérez Macho, Cristina Pacho Pacho, Miriam Mateo Roca, Jordi Casademont Pou, Domingo Ruiz Hidalgo
OBJECTIVES: To analyze factors related to drug-resistant pathogens (DRPs) in community-onset pneumonia (COP) and whether previously suggested criteria are useful in our emergency-department. MATERIAL AND METHODS: Prospective 1-year study of adults coming to the emergency department for COP. We assessed the usefulness of criteria used in health-care-associated pneumonia (HCAP), as well the Shorr index, the Barthel index, and clinical suspicion of resistant pathogens...
October 2017: Emergencias
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