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JOURNAL ARTICLE
Chao Zhang, Shuixian Zhang, Yi Yin, Long Wang, Lan Li, Chuan Lan, Jiantao Shi, Zhouyang Jiang, Hongfei Ge, Xuegang Li, Zaiyong Ao, Shengli Hu, Jingyu Chen, Hua Feng, Rong Hu
BACKGROUND: Decompressive craniectomy, a surgery to remove part of the skull and open the dura mater, maybe an effective treatment for controlling intracranial hypertension. It remains great interest to elucidate whether decompressive craniectomy is beneficial to intracerebral hemorrhage patients who warrant clot removal to prevent intracranial hypertension. METHODS: The trial was a prospective, pragmatic, controlled trial involving adult patients with intracerebral hemorrhage who were undergoing removal of hematoma...
April 19, 2024: International Journal of Surgery
#22
JOURNAL ARTICLE
Jun Kiat Ho, Tze Phei Kee, Wickly Lee
RATIONALE: Wide neck bifurcation aneurysms (WNBA) are technically challenging for both surgical and endovascular treatments. Endovascular treatment for WNBA often requires dual antiplatelet therapy (DAPT) post stent insertion. Novel devices such as the pCONUS2 HPC neck bridging device have an HPC coating which reduces the device thrombogenicity. This theoretically allows for use of single antiplatelet therapy (SAPT), which would be advantageous, particularly in treating ruptured aneurysms...
April 19, 2024: Medicine (Baltimore)
#23
JOURNAL ARTICLE
Xian Wang, Wei Tian, Yongfeng Zhao, Yong Yang, Li Deng
The inflammatory response is involved in the progression of aneurysmal subarachnoid hemorrhage (aSAH). We sought to investigate the relationships of inflammatory indicators including blood cell counts and the ratios of different blood cells counts with the prognosis of aSAH patients. We performed a retrospective study including 140 patients with aSAH and aneurysm surgeries. The relationships of neutrophils, lymphocytes, monocytes, platelets, systemic immune inflammation index (SII), system inflammation response index (SIRI), neutrophil-lymphocyte ratio and platelet-lymphocyte ratio with prognosis were investigated by univariable analysis and multivariable logistic regression model...
April 19, 2024: Medicine (Baltimore)
#24
JOURNAL ARTICLE
R R M M Knapen, M Celen, F M E Pinckaers, B A J M Wagemans, W H van Zwam, R J van Oostenbrugge, C van der Leij
PURPOSE: Balloon guide catheters (BGCs) are used in endovascular treatment (EVT) for ischemic stroke. Previous literature did not distinguish between BGC use with and without inflated balloon. This study aims to compare outcomes between non-BCG and BGC use with and without inflated balloon during EVT. METHODS: Patients who underwent EVT for anterior circulation ischemic stroke between September 2020 and February 2023 were analyzed. Patients were divided into three groups: non-BGC, BGC with inflated balloon, or BGC without inflated balloon...
April 19, 2024: Cardiovascular and Interventional Radiology
#25
JOURNAL ARTICLE
Cornelius Deuschl, Lukas Goertz, Christoph Kabbasch, Martin Köhrmann, Christoph Kleinschnitz, Ansgar Berlis, Christoph Johannes Maurer, Iris Mühlen, Bernd Kallmünzer, Matthias Gawlitza, Daniel P O Kaiser, Joachim Klisch, Donald Lobsien, Daniel Behme, Maximilian Thormann, Fabian Flottmann, Laurens Winkelmeier, Elke Ruth Gizewski, Lukas Mayer-Suess, Markus Holtmannspoetter, Christoph Moenninghoff, Martin Schlunz-Hendann, Dominik Grieb, Christophe T Arendt, Ferdinand O Bohmann, Jens Altenbernd, Yan Li, Ulrich Sure, Ruben Mühl-Benninghaus, Thomas Rodt, Kai Kallenberg, Alexandru Durutya, Mohamed Elsharkawy, Christian-Paul Stracke, Mathias Gerhard Schumann, Alexander Bock, Omid Nikoubashman, Martin Wiesmann, Hans Henkes, Sebastian Dolff, Aydin Demircioglu, Michael Forsting, Hanna Styczen
BACKGROUND: Data on impact of COVID-19 vaccination and outcomes of patients with COVID-19 and acute ischemic stroke undergoing mechanical thrombectomy are scarce. Addressing this subject, we report our multicenter experience. METHODS AND RESULTS: This was a retrospective analysis of patients with COVID-19 and known vaccination status treated with mechanical thrombectomy for acute ischemic stroke at 20 tertiary care centers between January 2020 and January 2023. Baseline demographics, angiographic outcome, and clinical outcome evaluated by the modified Rankin Scale score at discharge were noted...
April 19, 2024: Journal of the American Heart Association
#26
JOURNAL ARTICLE
Mai T H Nguyen, Yuki Sakamoto, Toshiki Maeda, Mark Woodward, Craig S Anderson, Jayson Catiwa, Amelia Yazidjoglou, Cheryl Carcel, Min Yang, Xia Wang
BACKGROUND: This review aimed to quantify the impact of socioeconomic status on functional outcomes from stroke and identify the socioeconomic status indicators that exhibit the highest magnitude of association. METHODS AND RESULTS: We performed a systematic literature search across Medline and Embase from inception to May 2022, to identify observational studies (n≥100, and in English). Risk of bias was assessed using the modified Newcastle Ottawa Scale. Random effects meta-analysis was used to pool data...
April 19, 2024: Journal of the American Heart Association
#27
JOURNAL ARTICLE
Leon A Rinkel, Olivia N Cramer, Z Beyda Özata, Chiel F P Beemsterboer, Valeria Guglielmi, Shan Sui Nio, Berto J Bouma, S Matthijs Boekholdt, Nick H J Lobé, Ludo F M Beenen, Henk A Marquering, Charles B L M Majoie, Yvo B W E M Roos, Adrienne van Randen, R Nils Planken, Jonathan M Coutinho
BACKGROUND: Cardiac computed tomography (CT) acquired during the initial acute stroke imaging protocol (acute cardiac CT) is increasingly used to screen for cardioembolism, but information on the long-term clinical implications of its findings is lacking. METHODS AND RESULTS: We performed a prospective, single-center cohort study in which consecutive patients with ischemic stroke underwent ECG-gated acute cardiac CT and were followed up for 2 years. The primary outcome was functional outcome assessed using the modified Rankin Scale...
April 19, 2024: Journal of the American Heart Association
#28
JOURNAL ARTICLE
Francisco Hernández-Bernal, Donner Estenoz-García, Juan H Gutiérrez-Ronquillo, Yenima Martín-Bauta, Karen Catasús-Álvarez, Mario Gutiérrez-Castillo, Marbelys Guevara-Rodríguez, Aliuska Castro-Jeréz, Yoandra Fuentes-González, Yulemis Pinto-Cruz, Carmen Valenzuela-Silva, Verena L Muzio-González, Héctor Pérez-Saad, Nelvys Subirós-Martínez, Gerardo E Guillén-Nieto, Diana Garcia-Del-Barco-Herrera
OBJECTIVE: This study tested the hypothesis that a neuroprotective combined therapy based on epidermal growth factor (EGF) and growth hormone-releasing hexapeptide (GHRP6) could be safe for acute ischemic stroke patients, admitting up to 30% of serious adverse events (SAE) with proven causality. METHODS: A multi-centric, randomized, open-label, controlled, phase I-II clinical trial with parallel groups was conducted (July 2017 to January 2018). Patients aged 18-80 years with a computed tomography-confirmed ischemic stroke and less than 12 h from the onset of symptoms were randomly assigned to the study groups I (75 μg rEGF + 3...
2024: Frontiers in Neurology
#29
JOURNAL ARTICLE
Lina Zheng, Ximing Nie, Mengxing Wang, Xin Liu, Wanying Duan, Zhe Zhang, Jingyi Liu, Yufei Wei, Miao Wen, Zhonghua Yang, Thomas W Leung, Gaoting Ma, Xiaochuan Huo, Yuesong Pan, Thanh N Nguyen, Xinyi Leng, Zhongrong Miao, Liping Liu
BACKGROUND: Endovascular therapy (EVT) was demonstrated effective in acute large vessel occlusion (LVO) with large infarction. Revealing subgroups of patients who would or would not benefit from EVT will further inform patient selection for EVT. METHODS: This post-hoc analysis of the ANGEL-ASPECT trial, a randomised controlled trial of 456 adult patients with acute anterior-circulation LVO and large infarction, defined by ASPECTS 3-5 or infarct core volume 70-100 mL, enrolled from 46 centres across China, between October 2, 2020 and May 18, 2022...
June 2024: EClinicalMedicine
#30
JOURNAL ARTICLE
Marina Guasch-Jiménez, Rajat Dhar, Atul Kumar, Julien Cifarelli, Garbiñe Ezcurra-Díaz, Álvaro Lambea-Gil, Anna Ramos-Pachón, Alejandro Martínez-Domeño, Luis Prats-Sánchez, Daniel Guisado-Alonso, Israel Fernández-Cadenas, Ana Aguilera-Simón, Rebeca Marín, José Pablo Martínez-González, Joaquin Ortega-Quintanilla, Isabel Fernández-Pérez, Carla Avellaneda-Gómez, Jorge Rodríguez-Pardo, Elena de Celis, Francisco Moniche, María Del Mar Freijo, Elisa Cortijo, Santiago Trillo, Pol Camps-Renom, Joan Martí-Fábregas
BACKGROUND: Cerebral edema (CED) is associated with poorer outcome in patients with acute ischemic stroke (AIS). The aim of the study was to investigate the factors contributing to greater early CED formation in patients with AIS who underwent endovascular therapy (EVT) and its association with functional outcome. METHODS: We conducted a multicenter cohort study of patients with an anterior circulation AIS undergoing EVT. The volume of cerebrospinal fluid (CSF) was extracted from baseline and 24-hour follow-up CT using an automated algorithm...
April 18, 2024: Journal of Neurointerventional Surgery
#31
JOURNAL ARTICLE
Mohammed Maan Al-Salihi, Syed A Gillani, Ram Saha, Mouhammad A Jumaa, Syed F Zaidi, Farhan Siddiq, Camilo R Gomez, Mikael Mazhigi, Adnan I Qureshi
BACKGROUND AND AIMS: There is no clear consensus on ideal systolic blood pressure (SBP) target post-endovascular thrombectomy (EVT) in patients with acute ischemic stroke. This study intends to investigate the relationship between reducing SBP and clinical outcomes and to determine the therapeutic efficacy of moderate and intensive SBP reduction post EVT. METHODS: A comprehensive search was conducted across five electronic databases to identify studies relevant to our analysis...
April 16, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#32
JOURNAL ARTICLE
Wu Yan, Wang Mengke, Su Zhiqiang, Gu Jiaao, Guan Fulin
INTRODUCTION: Autoimmune encephalitis (AE) is a rare, treatable disease of the central nervous system (CNS) caused by an antibody-related immune response. This study is to investigate the correlation of clinical features, cerebrospinal fluid (CSF) characteristics, and prognosis in patients with AE. METHODS: A total of 71 patients diagnosed with antibody-positive AE were retrospectively analyzed. The patients were divided into three groups: anti-NMDAR group, anti-LGI1 group, and other types...
April 18, 2024: Acta Neurologica Belgica
#33
JOURNAL ARTICLE
Michael G Brandel, Jillian H Plonsker, Robert C Rennert, Gautam Produturi, Megana Saripella, Arvin R Wali, Carson McCann, Vijay M Ravindra, David R Santiago-Dieppa, J Scott Pannell, Jeffrey A Steinberg, Alexander A Khalessi, Michael L Levy
INTRODUCTION: Pediatric intracranial aneurysms (IAs) are rare and have distinct clinical profiles compared to adult IAs. They differ in location, size, morphology, presentation, and treatment strategies. We present our experience with pediatric IAs over an 18-year period using surgical and endovascular treatments and review the literature to identify commonalities in epidemiology, treatment, and outcomes. METHODS: We identified all patients < 20 years old who underwent treatment for IAs at our institution between 2005 and 2020...
April 18, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#34
JOURNAL ARTICLE
Elizabeth P Crowe, Luisa A Diaz-Arias, Ralph Habis, Sonja O Vozniak, Romergryko G Geocadin, Arun Venkatesan, Aaron A R Tobian, John C Probasco, Evan M Bloch
INTRODUCTION: Autoimmune encephalitis (AE) comprises a heterogeneous group of autoantibody-mediated disorders targeting the brain parenchyma. Therapeutic plasma exchange (TPE), one of several first-line therapies for AE, is often initiated when AE is suspected, albeit prior to an established diagnosis. We sought to characterize the role of TPE in the treatment of suspected AE. METHODS: A single-center, retrospective analysis was performed of adults (≥18 years) who underwent at least one TPE procedure for "suspected AE...
June 2024: Journal of Clinical Apheresis
#35
Gansheng Tan, Anna L Huguenard, Kara M Donovan, Phillip Demarest, Xiaoxuan Liu, Ziwei Li, Markus Adamek, Kory Lavine, Ananth K Vellimana, Terrance T Kummer, Joshua W Osbun, Gregory J Zipfel, Peter Brunner, Eric C Leuthardt
OBJECTIVE: Subarachnoid hemorrhage (SAH) is characterized by intense central inflammation, leading to substantial post-hemorrhagic complications such as vasospasm and delayed cerebral ischemia. 2,6,7 Given the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation (taVNS) and its ability to promote brain plasticity, taVNS has emerged as a promising therapeutic option for SAH patients. 3,8,9 However, the effects of taVNS on cardiovascular dynamics in critically ill patients like those with SAH have not yet been investigated...
April 3, 2024: medRxiv
#36
JOURNAL ARTICLE
Xuan Yang, Kaixin Wang, Ping Shen, Tong Zhou, Yudi Xu, Yufei Chen, Yanfei Li, Yaobing Yao, Zhe Gong, Ranran Duan, Lijun Jing, Yanjie Jia
PURPOSE: Sphingosine-1-phosphate (S1P) is a signaling lipid involved in many biological processes, including inflammatory and immune regulatory responses. The study aimed to determine whether admission S1P levels are associated with disease severity and prognosis after spontaneous intracerebral hemorrhage (ICH). METHODS: Data of 134 patients with spontaneous ICH and 120 healthy controls were obtained from Biological Resource Sample Database of Intracerebral Hemorrhage at the First Affiliated Hospital of Zhengzhou University...
2024: Frontiers in Neurology
#37
JOURNAL ARTICLE
Dominik Wróbel, Paweł Wrona, Tomasz Homa, Klaudia Jakobschy, Gabriela Wrona, Katarzyna Sawczyńska, Mateusz Giełczyński, Tadeusz Popiela, Agnieszka Słowik, Wojciech Turaj
INTRODUCTION: The discourse surrounding differences in cerebral hemodynamics and clinical outcomes among male and female patients treated with mechanical thrombectomy (MT) for acute ischemic stroke (AIS) remains unresolved. We aimed to elucidate these differences by employing computed tomography perfusion (CTP) imaging before MT and examining the influence of perfusion deficits on the 90-day functional outcome. METHODS: This single-center retrospective analysis involved patients with anterior circulation AIS treated with MT at the Comprehensive Stroke Center, University Hospital, Krakow from January 2019 to July 2023...
April 17, 2024: Cerebrovascular Diseases
#38
JOURNAL ARTICLE
Jae Wook Jung, Kwang Hyun Kim, Jaeseob Yun, Young Dae Kim, JoonNyung Heo, Hyungwoo Lee, Jin Kyo Choi, Il Hyung Lee, In Hwan Lim, Soon-Ho Hong, Byung Moon Kim, Dong Joon Kim, Na Young Shin, Bang-Hoon Cho, Seong Hwan Ahn, Hyungjong Park, Sung-Il Sohn, Jeong-Ho Hong, Tae-Jin Song, Yoonkyung Chang, Gyu Sik Kim, Kwon-Duk Seo, Kijeong Lee, Jun Young Chang, Jung Hwa Seo, Sukyoon Lee, Jang-Hyun Baek, Han-Jin Cho, Dong Hoon Shin, Jinkwon Kim, Joonsang Yoo, Minyoul Baik, Kyung-Yul Lee, Yo Han Jung, Yang-Ha Hwang, Chi Kyung Kim, Jae Guk Kim, Chan Joo Lee, Sungha Park, Soyoung Jeon, Hye Sun Lee, Sun U Kwon, Oh Young Bang, Ji Hoe Heo, Hyo Suk Nam
IMPORTANCE: The associations between blood pressure (BP) decreases induced by medication and functional outcomes in patients with successful endovascular thrombectomy remain uncertain. OBJECTIVE: To evaluate whether BP reductions induced by intravenous BP medications are associated with poor functional outcomes at 3 months. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was a post hoc analysis of the Outcome in Patients Treated With Intra-Arterial Thrombectomy-Optimal Blood Pressure Control trial, a comparison of intensive and conventional BP management during the 24 hours after successful recanalization from June 18, 2020, to November 28, 2022...
April 1, 2024: JAMA Network Open
#39
JOURNAL ARTICLE
Amit Kumar Sharma, Ruhi Mamualiya, Atul Agrawal
BACKGROUND: Various clinical symptoms and variables have been suggested as potential indicators of outcomes in patients with subarachnoid hemorrhage (SAH) resulting from ruptured intracranial aneurysms. The detailed discussion of the consequences of intraventricular hemorrhage (IVH), frequently reported in cases of anterior communicating artery (ACoA) aneurysms, is still pending. The study aimed to assess the results of aneurysm surgery performed early versus delayed in patients with SAH, specifically focusing on the occurrence of IVH...
2024: Surgical Neurology International
#40
JOURNAL ARTICLE
Talita Helena Martins Sarti, Marcos Devanir Silva da Costa, Daniel Paz Araujo, Rodrigo Akira Watanabe, Samuel Tau Zymberg, Ítalo Capraro Suriano, Sergio Cavalheiro, Feres Chaddad-Neto
BACKGROUND: Intraventricular hemorrhage (IVH) is a complex condition with both mechanical and chemical effects, resulting in mortality rates of 50-80%. Recent reports advocate for neuroendoscopic treatment, particularly endoscopic brainwashing (EBW), but long-term functional outcomes remain insufficiently explored. This study aims to outline the step-by-step procedure of EBW as applied in our institution, providing results and comparing them with those of external ventricular drainage (EVD) alone...
2024: Surgical Neurology International
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