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https://www.readbyqxmd.com/read/29690727/-clinical-experience-and-next-generation-sequencing-analysis-of-encephalitis-caused-by-pseudorabies-virus
#1
W L Zhao, Y H Wu, H F Li, S Y Li, S Y Fan, H L Wu, Y J Li, Y L Lü, J Han, W C Zhang, Y Zhao, G L Li, X D Qiao, H T Ren, Y C Zhu, B Peng, L Y Cui, H Z Guan
Objective: To detect potential pathogens including pseudorabies virus in patients with encephalitis of unknown etiology in China and describe novel encephalitic entities. Methods: Patients with clinically suspected infectious encephalitis were enrolled in a multicenter study to identify the pathogens in PUMCH Encephalitis Program.Next-generation sequencing(NGS) of cerebrospinal fluid (CSF) was used in patients with encephalitis of unknown etiology enrolled from 2016 to 2017.The patients diagnosed as PRV encephalitis were studied to describe this novel entity...
April 17, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29689434/estimating-the-cost-effectiveness-of-lung-cancer-screening-with-low-dose-computed-tomography-for-high-risk-smokers-in-australia
#2
Stephen Wade, Marianne Weber, Michael Caruana, Yoon-Jung Kang, Henry Marshall, Renee Manser, Shalini Vinod, Nicole Rankin, Kwun Fong, Karen Canfell
BACKGROUND: Health economic evaluations of lung cancer screening with low dose computerised tomography (LDCT) that are underpinned by clinical outcomes are few. METHODS: We assessed the cost-effectiveness of LDCT lung screening in Australia by applying Australian cost and survival data to the outcomes observed in the U.S. National Lung Screening Trial (NLST), in which a 20% lung cancer mortality benefit was demonstrated for three rounds of annual screening among high-risk smokers aged 55-74 years...
April 21, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29689401/persistent-high-levels-of-mir-502-5p-are-associated-with-poor-neurological-outcome-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#3
Bin Sheng, Xinggen Fang, Cegang Liu, Degang Wu, Dayong Xia, Shanshui Xu, Niansheng Lai
OBJECTIVE: To investigate the temporal changes in miR-502-5p expression after aneurysmal subarachnoid hemorrhage (aSAH) and to find the time to peak level. METHODS: We collected serum from patients with aSAH (n = 129) at various time points (1, 3, 7, and 14 days post-event) and healthy controls (n = 40), at the Department of Neurosurgery, the First Affiliated Hospital of Wannan Medical College, from 1 May 2015 to 31 January 2016. We measured expression levels of miR-502-5p by PCR...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29689135/intravenous-thrombolysis-in-unwitnessed-stroke-onset-mr-witness-trial-results
#4
Lee H Schwamm, Ona Wu, Shlee S Song, Lawrence L Latour, Andria L Ford, Amie W Hsia, Alona Muzikansky, Rebecca A Betensky, Albert J Yoo, Michael H Lev, Gregoire Boulouis, Arne Lauer, Pedro Cougo, William A Copen, Gordon J Harris, Steven Warach
OBJECTIVE: Most acute ischemic stroke (AIS) patients with unwitnessed symptom onset are ineligible for intravenous thrombolysis due to timing alone. Lesion evolution on FLAIR MRI correlates with stroke duration, and quantitative mismatch of diffusion-weighted MRI (DWI) with FLAIR (qDFM) might indicate stroke duration within guideline-recommended thrombolysis. We tested if intravenous thrombolysis ≤4.5 h from time of symptom discovery is safe in patients with qDFM in an open-label, phase 2a, prospective study (NCT01282242)...
April 24, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29688976/in-reply
#5
Winston Liaw, Jennifer Rankin, Andrew Bazemore, William Ventres
No abstract text is available yet for this article.
May 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29688482/lumboperitoneal-shunts-for-the-treatment-of-idiopathic-normal-pressure-hydrocephalus-a-comparison-of-small-lumen-abdominal-catheters-to-gravitational-add-on-valves-in-a-single-center
#6
Madoka Nakajima, Masakazu Miyajima, Chihiro Akiba, Ikuko Ogino, Kaito Kawamura, Hidenori Sugano, Takeshi Hara, Yuichi Tange, Keiko Fusegi, Kostadin Karagiozov, Hajime Arai
BACKGROUND: Treating idiopathic normal pressure hydrocephalus (iNPH) with lumboperitoneal shunts (LPSs) may cause cerebrospinal fluid (CSF) overdrainage. OBJECTIVE: To investigate whether LPSs, including gravitational "add-on" and programmable pressure valves (PPVs/+GVs), reduce complications and improve outcomes. METHODS: We compared PPVs/+small lumen abdominal catheters (SLs) to PPVs/+GVs using different opening pressures for supine and standing positions...
April 23, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29685412/posterior-fossa-avms-increased-risk-of-bleeding-and-worse-outcome-compared-to-supratentorial-avms
#7
Nazife Dinc, Johannes Platz, Stephanie Tritt, Johanna Quick-Weller, Michael Eibach, Robert Wolff, Joachim Berkefeld, Volker Seifert, Gerhard Marquardt
Infratentorial AVMs are often considered as potentially hazardous as they are thought to present more often with hemorrhage, may harbor AVM-associated aneurysms more frequently and to be associated with poor outcome. The aim of our study is to compare features of supratentorial and infratentorial AVMs. We retrospectively analyzed 316 consecutive patients with cerebral AVM presenting to our neurovascular center between 2005 and 2015. Location and angioarchitecture of the AVM including AVM-associated aneurysms, bleeding events, and outcome during follow up were analyzed...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29684518/long-term-outcomes-after-encephaloduroarteriosynangiosis-in-adult-patients-with-moyamoya-disease-presenting-with-ischemia
#8
Xiang-Yang Bao, Yong Zhang, Qian-Nan Wang, Qian Zhang, Hui-Wang, Zheng-Shan Zhang, De-Sheng Li, Lian Duan
BACKGROUND: In adult Moyamoya disease(MMD), there remains controversy about the effectiveness of revascularization surgeries because randomized studies have not been performed to compare the efficacy of surgical techniques. OBJECT: There is an ongoing controversy regarding the most appropriate surgical treatment for adult patients with MMD. METHODS: Encephaloduroarteriosynangiosis (EDAS) was performed on 247 hemispheres in 145 patients. The clinical and demographic characteristics of patients were obtained via retrospective chart review...
April 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29683964/outcomes-of-anesthesia-selection-in-endovascular-treatment-of-acute-ischemic-stroke
#9
Yuming Peng, Youxuan Wu, Xiaochuan Huo, Peng Wu, Yang Zhou, Jiaxin Li, Fa Liang, Xiaoyuan Liu, Yuesong Pan, Zhongrong Miao, Ruquan Han
BACKGROUND: The association between anesthesia type and outcomes in patients with acute ischemic stroke undergoing endovascular treatment (EVT) remains a subject of ongoing debate. METHODS: This prospective nonrandomized controlled trial included 149 consecutive patients with acute anterior circulation stroke who underwent EVT. The primary outcome was functional independence assessed by the modified Rankin Scale (mRS) after 3 months. RESULTS: A total of 105 (70...
April 20, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29683786/real-world-treatment-of-large-vessel-occlusions-combined-outcomes-of-directly-presenting-and-transferred-in-patients-to-a-stroke-center
#10
Ganesh Asaithambi, Amy L Castle, Lana J Stein, Emily H Marino, Bridget M Ho, Andrew C Wallace-Jackson, Sandra K Hanson, Jeffrey P Lassig
Background Stroke patients transferred in for endovascular treatment (ET) may have lower chances for favorable outcomes compared to those who presented directly to a ET-capable hospital. We describe our real-world experience of ET in AIS, especially among patients transferred in. Materials and methods AIS patients receiving ET from January 2015 to November 2016 were reviewed. We calculated median onset to groin puncture (OTP) and groin puncture to recanalization times (PTR), location of target vessel treated, rate of concurrent intravenous (IV) alteplase use, and rate of successful recanalization as defined by TICI ≥ 2b...
April 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29682071/intraoperative-rupture-cerebral-aneurysm-and-computational-flow-dynamics
#11
Ilya Senko, Anton Shatokhin, Ishu Bishnoi, Yasuhiro Yamada, Riki Tanaka, Daisuke Suyama, Tukasa Kawase, Yoko Kato
Intraoperative aneurysmal rupture (IAR) is the most fearsome complication of aneurysm surgery. IAR associates with high morbidity and mortality. In recent years, we have many studies regarding using computational fluid dynamics (CFD) in aneurysm surgery. CFD helps in calculating the velocity of blood flowing in the aneurysm sac, the pressure in the aneurysm sac, and wall shear stress (WSS). CFD also helps in predicting nature of aneurysm wall and thus may warn about different intraoperative microscopy findings in aneurysms...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681960/first-uses-of-haart-300-rings-for-aortic-valve-repair-in-poland-4-case-studies
#12
Jacek H Juściński, Andrzej Koprowski, Magdalena Kołaczkowska, Maciej M Kowalik, Jan A Rogowski, James S Rankin
Introduction: Aortic valve reconstructions using geometric annuloplasty rings HAART 300/200 open new era in aortic valve surgery. The HAART technology resizes, reshapes, stabilizes and simplifies aortic valve repair. The HAART aortic repair rings are designed to be implanted directly into aortic annulus (under aortic valve leaflets). Aim: We present first in Poland 4 cases of aortic valve reconstructions using geometric annuloplasty rings HAART 300. Material and methods: Two patients had type IA aortic insufficiency (due to El-Khoury classification) - they were treated by HAART 300 ring insertion and ascending aorta prosthesis implantation...
March 2018: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/29680819/a-single-center-experience-in-the-endovascular-treatment-of-carotid-siphon-aneurysms-using-the-willis-covered-stent-a-retrospective-analysis
#13
Lin Ma, Ji-Chong Xu, Shuo Yan, Hao Feng, Hong-Jie Han, Hua-Qiao Tan, Chun Fang, Hong-En Huang
OBJECTIVE: To report the clinical results and initial clinical experience of endovascular isolation with the Willis covered stent for carotid siphon aneurysms. METHODS: Between November 2013 and December 2016, a total of 57 patients who presented with carotid siphon aneurysms were treated with the Willis covered stent. Results of the procedures, technical events, and complications were recorded. Clinical and imaging follow-ups were performed at 3 months following the endovascular procedures...
April 21, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29679782/outcomes-after-off-label-use-of-the-pipeline-embolization-device-for-intracranial-aneurysms-a-multicenter-cohort-study
#14
S G Zammar, T J Buell, C J Chen, R W Crowley, D Ding, C J Griessenauer, B L Hoh, K C Liu, C S Ogilvy, Raper, A Singla, A J Thomas, K M Cockroft, S D Simon
OBJECTIVES: The aim of this retrospective multicenter cohort study is to examine the outcomes of the Pipeline embolization device (PED) for the treatment of intracranial aneurysms outside of United States Food and Drug Administration approved (off-label) indications. METHODS: Data from aneurysm patients treated with the PED for off-label indications was pooled from four different centers. The primary endpoints were decline in modified Rankin Scale (mRS) by at least 1 point and angiographic aneurysm occlusion at follow-up...
April 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678936/effect-of-stroke-thrombolysis-predicted-by-distal-vessel-occlusion-detection
#15
Wolfgang G Kunz, Matthias P Fabritius, Wieland H Sommer, Christopher Höhne, Pierre Scheffler, Lukas T Rotkopf, Wolfgang P Fendler, Bastian O Sabel, Felix G Meinel, Franziska Dorn, Birgit Ertl-Wagner, Maximilian F Reiser, Kolja M Thierfelder
OBJECTIVE: Among ischemic stroke patients with negative CT angiography (CTA), we aimed to determine the predictive value of enhanced distal vessel occlusion detection using CT perfusion postprocessing (waveletCTA) for the treatment effect of IV thrombolysis (IVT). METHODS: Patients were selected from 1,851 consecutive patients who had undergone CT perfusion. Inclusion criteria were (1) significant cerebral blood flow (CBF) deficit, (2) no occlusion on CTA, and (3) infarction confirmed on follow-up...
April 20, 2018: Neurology
https://www.readbyqxmd.com/read/29678090/a-system-for-supporting-development-and-update-of-the-international-classification-of-health-interventions-ichi
#16
Marc Donada, Vincenzo Della Mea, Megan Cumerlato, Nicole Rankin, Richard Madden
The International Classification of Health Interventions (ICHI) is a member of the WHO Family of International Classifications, being developed to provide a common tool for reporting and analysing health interventions for statistical purposes. A web-based platform for classification development and update has been specifically developed to support the initial development step and then, after final approval, the continuous revision and update of the classification. The platform provides features for classification editing, versioning, comment management and URI identifiers...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677509/beyond-host-defense-emerging-functions-of-the-immune-system-in-regulating-complex-tissue-physiology
#17
REVIEW
Lucille C Rankin, David Artis
The essential roles played by the immune system in the discrimination between self- versus non/altered-self and its integral role in promoting host defense against invading microbes and tumors have been extensively studied for many years. In these contexts, significant advances have been made in defining the molecular and cellular networks that orchestrate cell-cell communication to mediate host defense and pathogen expulsion. Notably, recent studies indicate that in addition to these classical immune functions, cells of the innate and adaptive immune system also sense complex tissue- and environment-derived signals, including those from the nervous system and the diet...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29676694/keyhole-strategy-aiming-at-minimizing-hospital-stay-for-surgical-clipping-of-unruptured-middle-cerebral-artery-aneurysms
#18
Kentaro Mori, Kojiro Wada, Naoki Otani, Arata Tomiyama, Terushige Toyooka, Satoru Takeuchi, Takuji Yamamoto, Yasuaki Nakao, Hajime Arai
OBJECTIVE Aneurysms of the middle cerebral artery (MCA) are still most often treated by clipping through standard craniotomy, but a longer hospital stay is one of the main drawbacks of this treatment. The authors developed a pterional keyhole clipping strategy for unruptured MCA aneurysms with the intention of minimizing hospital stay. In this paper, they report on their experience with this approach and analyze the long-term neurological and radiological outcomes. METHODS A total of 160 relatively small unruptured MCA aneurysms (mean 6...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676403/combined-endoscopic-transorbital-and-endonasal-repair-of-high-flow-orbital-apex-middle-fossa-cerebrospinal-fluid-leak-with-a-nasoseptal-flap
#19
Brandon Lucke-Wold, Gustavo Mendez, David Cua, Paul Akins, Haley Gillham, Jeremy Ciporen
Background and importance: High flow orbital apex or middle fossa cerebrospinal fluid (CSF) leaks can be life threatening and complex to repair. These leaks associated with large dural defects are most commonly repaired with an open temporalis muscle patch or free flaps, but these flaps do not always stop the leak. Clinical Presentation: A 65-year-old patient presented two years after orbital exenteration and radiation for squamous cell carcinoma. He developed multi-organism meningitis and pneumocephalus secondary to a large high-flow orbital apex/middle fossa CSF leak...
2018: Journal of neuroinflammation and neurodegenerative diseases
https://www.readbyqxmd.com/read/29676225/post-stroke-social-networks-depressive-symptoms-and-disability-in-tanzania-a-prospective-study
#20
Altaf Saadi, Kigocha Okeng'o, Maijo R Biseko, Agness F Shayo, Theoflo N Mmbando, Sara J Grundy, Ai Xu, Robert A Parker, Leah Wibecan, Geetha Iyer, Peter M Onesmo, Boniphace N Kapina, Robert W Regenhardt, Farrah J Mateen
Background Evidence suggests that social networks improve functional recovery after stroke, but this work has not been extended to low- and middle-income countries (LMICs). Post-stroke depression interferes with functional outcome but is understudied in LMICs. Aims To determine the relationships between social networks, disability, and depressive symptoms in patients surviving 90-days post-stroke in Dar es Salaam, Tanzania. Methods Participants ≥ 18 years, admitted ≤ 14 days of stroke onset, were enrolled...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
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