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JOURNAL ARTICLE
Alice Long, Christian J Oswood, Christopher B Kelly, Marian C Bryan, David W C MacMillan
Heteroarenes are ubiquitous motifs in bioactive molecules, conferring favourable physical properties when compared to their arene counterparts1-3 . In particular, semisaturated heteroarenes possess attractive solubility properties and a higher fraction of sp3 carbons, which can improve binding affinity and specificity. However, these desirable structures remain rare owing to limitations in current synthetic methods4-6 . Indeed, semisaturated heterocycles are laboriously prepared by means of non-modular fit-for-purpose syntheses, which decrease throughput, limit chemical diversity and preclude their inclusion in many hit-to-lead campaigns7-10 ...
March 13, 2024: Nature
#22
JOURNAL ARTICLE
Prem N Ramkumar, Reena J Olsen, Hashim J F Shaikh, Danyal H Nawabi, Bryan T Kelly
BACKGROUND: Little is known about the effect of modern hip arthroscopy on the natural history of femoroacetabular impingement syndrome (FAIS) with respect to joint preservation. PURPOSE: To (1) characterize the natural history of FAIS and (2) understand the effect of modern hip arthroscopy by radiographically comparing the hips of patients who underwent only unilateral primary hip arthroscopy with a minimum follow-up of 10 years. STUDY DESIGN: Cohort study; Level of evidence, 3...
April 2024: American Journal of Sports Medicine
#23
JOURNAL ARTICLE
Kensuke Shinohara, Peter O Newton, Michael P Kelly, Vidyadhar V Upasani, Carrie E Bartley, Tracey P Bryan
STUDY DESIGN: Retrospective. OBJECTIVE: Evaluate whether the use of vancomycin powder (VP) placed in the surgical site prior to wound closure prevents delayed deep surgical site infections (DDI). SUMMARY OF BACKGROUND DATA: DDI after posterior spinal fusion (PSF) in adolescent idiopathic scoliosis (AIS) patients remains a significant major complication. The use of VP to prevent acute surgical site infection has been reported but the impact on DDI is unknown...
March 7, 2024: Spine
#24
REVIEW
Jacob F Oeding, Linjun Yang, Joaquin Sanchez-Sotelo, Christopher L Camp, Jón Karlsson, Kristian Samuelsson, Andrew D Pearle, Anil S Ranawat, Bryan T Kelly, Ayoosh Pareek
Deep learning is a subset of artificial intelligence (AI) with enormous potential to transform orthopaedic surgery. As has already become evident with the deployment of Large Language Models (LLMs) like ChatGPT (OpenAI Inc.), deep learning can rapidly enter clinical and surgical practices. As such, it is imperative that orthopaedic surgeons acquire a deeper understanding of the technical terminology, capabilities and limitations associated with deep learning models. The focus of this series thus far has been providing surgeons with an overview of the steps needed to implement a deep learning-based pipeline, emphasizing some of the important technical details for surgeons to understand as they encounter, evaluate or lead deep learning projects...
March 2024: Knee Surgery, Sports Traumatology, Arthroscopy
#25
EDITORIAL
Charles S Bryan, Devin M Kellis, Daniel Sokol
No abstract text is available yet for this article.
February 27, 2024: BMJ: British Medical Journal
#26
JOURNAL ARTICLE
Bianca Lopez, Jake S Yeston, Phil Szuromi, Sacha Vignieri, Michael A Funk, Keith T Smith, Hannah M Isles, L Bryan Ray, Gemma Alderton, Ian S Osborne, Yevgeniya Nusinovich, Corinne Simonti, Priscilla N Kelly, H Jesse Smith, Leslie K Ferrarelli, Melissa L Norton
Highlights from the Science family of journals.
February 23, 2024: Science
#27
JOURNAL ARTICLE
Theodore Heyming, Chloe Knudsen-Robbins, John Schomberg, Jennifer Hayakawa, Bryan Lara, Kellie Bacon, Brooke Valdez, Maxwell Wickens, Shelby K Shelton, Jonathan Romain, Elizabeth Wallace, Sharief Taraman, William Loudon, Rachel Pearson
BACKGROUND: Although millions of children sustain concussions each year, a rapid and objective test for concussion has remained elusive. The aim of this study was to investigate quantitative pupillometry in pediatric patients in the acute, postinjury setting. METHODS: This was a prospective case-control study of concussed patients presenting to the emergency department within 72 hours of injury. Pupillary measurements were gathered using NeurOptics' PLR 3000; evaluation included a symptom checklist and neurocognitive assessment...
April 2024: Pediatric Neurology
#28
JOURNAL ARTICLE
Alessandra Alteri, Gemma Arroyo, Giuliana Baccino, Laurentiu Craciunas, Christian De Geyter, Thomas Ebner, Martina Koleva, Klaudija Kordic, Saria Mcheik, Heidi Mertes, Dinka Pavicic Baldani, Kenny A Rodriguez-Wallberg, Ioana Rugescu, Samuel Santos-Ribeiro, Kelly Tilleman, Bryan Woodward, Nathalie Vermeulen, Zdravka Veleva
STUDY QUESTION: Which clinical and embryological factors should be considered to apply double embryo transfer (DET) instead of elective single embryo transfer (eSET)? SUMMARY ANSWER: No clinical or embryological factor per se justifies a recommendation of DET instead of eSET in IVF/ICSI. WHAT IS KNOWN ALREADY: DET is correlated with a higher rate of multiple pregnancy, leading to a subsequent increase in complications for both mother and babies...
February 14, 2024: Human Reproduction
#29
JOURNAL ARTICLE
Bryan Ng, Jane Vowles, Féodora Bertherat, Ajantha Abey, Peter Kilfeather, Dayne Beccano-Kelly, M Irina Stefana, Darragh P O'Brien, Nora Bengoa-Vergniory, Phillippa J Carling, John A Todd, Tara M Caffrey, Natalie Connor-Robson, Sally A Cowley, Richard Wade-Martins
Alzheimer's disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological accumulation of extracellular plaques and intracellular neurofibrillary tangles that mainly consist of amyloid-β (Aβ) and hyperphosphorylated tau aggregates, respectively. Previous studies in mouse models with a targeted knock-out of the microtubule-associated protein tau (Mapt) gene demonstrated that Aβ-driven toxicity is tau-dependent. However, human cellular models with chronic tau lowering remain unexplored...
February 15, 2024: Molecular Psychiatry
#30
JOURNAL ARTICLE
Christina L Roland, Elise F Nassif Haddad, Emily Z Keung, Wei-Lien Wang, Alexander J Lazar, Heather Lin, Manoj Chelvanambi, Edwin R Parra, Khalida Wani, B Ashleigh Guadagnolo, Andrew J Bishop, Elizabeth M Burton, Kelly K Hunt, Keila E Torres, Barry W Feig, Christopher P Scally, Valerae O Lewis, Justin E Bird, Ravin Ratan, Dejka Araujo, M Alexandra Zarzour, Shreyaskumar Patel, Robert Benjamin, Anthony P Conley, J Andrew Livingston, Vinod Ravi, Hussein A Tawbi, Patrick P Lin, Bryan S Moon, Robert L Satcher, Bilal Mujtaba, Russell G Witt, Raymond S Traweek, Brandon Cope, Rossana Lazcano, Chia-Chin Wu, Xiao Zhou, Mohammad M Mohammad, Randy A Chu, Jianhua Zhang, Ashish Damania, Pranoti Sahasrabhojane, Taylor Tate, Kate Callahan, Sa Nguyen, Davis Ingram, Rohini Morey, Shadarra Crosby, Grace Mathew, Sheila Duncan, Cibelle F Lima, Jean-Yves Blay, Wolf Herman Fridman, Kenna Shaw, Ignacio Wistuba, Andrew Futreal, Nadim Ajami, Jennifer A Wargo, Neeta Somaiah
Based on the demonstrated clinical activity of immune-checkpoint blockade (ICB) in advanced dedifferentiated liposarcoma (DDLPS) and undifferentiated pleomorphic sarcoma (UPS), we conducted a randomized, non-comparative phase 2 trial ( NCT03307616 ) of neoadjuvant nivolumab or nivolumab/ipilimumab in patients with resectable retroperitoneal DDLPS (n = 17) and extremity/truncal UPS (+ concurrent nivolumab/radiation therapy; n = 10). The primary end point of pathologic response (percent hyalinization) was a median of 8...
February 13, 2024: Nature Cancer
#31
JOURNAL ARTICLE
Raul D Isern, Marvin J Bittner, Faran Ahmad, Kelly Biermann, Bryan J Krajicek, Venkata G Andukuri, Manasa Velagapudi
No abstract text is available yet for this article.
2024: Proceedings of the Baylor University Medical Center
#32
JOURNAL ARTICLE
Foivos Georgiadis, Sara Larivière, David Glahn, L Elliot Hong, Peter Kochunov, Bryan Mowry, Carmel Loughland, Christos Pantelis, Frans A Henskens, Melissa J Green, Murray J Cairns, Patricia T Michie, Paul E Rasser, Stanley Catts, Paul Tooney, Rodney J Scott, Ulrich Schall, Vaughan Carr, Yann Quidé, Axel Krug, Frederike Stein, Igor Nenadić, Katharina Brosch, Tilo Kircher, Raquel Gur, Ruben Gur, Theodore D Satterthwaite, Andriana Karuk, Edith Pomarol-Clotet, Joaquim Radua, Paola Fuentes-Claramonte, Raymond Salvador, Gianfranco Spalletta, Aristotle Voineskos, Kang Sim, Benedicto Crespo-Facorro, Diana Tordesillas Gutiérrez, Stefan Ehrlich, Nicolas Crossley, Dominik Grotegerd, Jonathan Repple, Rebekka Lencer, Udo Dannlowski, Vince Calhoun, Kelly Rootes-Murdy, Caroline Demro, Ian S Ramsay, Scott R Sponheim, Andre Schmidt, Stefan Borgwardt, Alexander Tomyshev, Irina Lebedeva, Cyril Höschl, Filip Spaniel, Adrian Preda, Dana Nguyen, Anne Uhlmann, Dan J Stein, Fleur Howells, Henk S Temmingh, Ana M Diaz Zuluaga, Carlos López Jaramillo, Felice Iasevoli, Ellen Ji, Stephanie Homan, Wolfgang Omlor, Philipp Homan, Stefan Kaiser, Erich Seifritz, Bratislav Misic, Sofie L Valk, Paul Thompson, Theo G M van Erp, Jessica A Turner, Boris Bernhardt, Matthias Kirschner
Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We tested whether large-scale structural alterations in schizophrenia relate to normative structural and functional connectome architecture, and systematically evaluated robustness and generalizability of these network-level alterations. Leveraging anatomical MRI scans from 2439 adults with schizophrenia and 2867 healthy controls from 26 ENIGMA sites and normative data from the Human Connectome Project (n = 207), we evaluated structural alterations of schizophrenia against two network susceptibility models: (i) hub vulnerability, which examines associations between regional network centrality and magnitude of disease-related alterations; (ii) epicenter mapping, which identifies regions whose typical connectivity profile most closely resembles the disease-related morphological alterations...
February 9, 2024: Molecular Psychiatry
#33
REVIEW
Jacob F Oeding, Aaron J Krych, Andrew D Pearle, Bryan T Kelly, Kyle N Kunze
PURPOSE: To (1) review definitions and concepts necessary to interpret applications of deep learning (DL; a domain of artificial intelligence (AI) that leverages neural networks to make predictions on media inputs such as images); and (2) identify knowledge and translational gaps in the literature to provide insight into specific areas for improvement as adoption of this technology continues. METHODS: A comprehensive search of the literature was performed in December 2023 for articles regarding the use of DL in sports medicine...
February 5, 2024: Arthroscopy
#34
JOURNAL ARTICLE
Amanda Hays, Mark Wissel, Kelly Colletti, Russell Soon, Mitra Azadeh, Justin Smith, Rajitha Doddareddy, Melanie Chalfant, Wendy Adamowicz, Swarna Suba Ramaswamy, Sanjay L Dholakiya, Sebastian Guelman, Bryan Gullick, Jennifer Durham, Keith Rennier, Pruthvi Nagilla, Anamica Muruganandham, Manisha Diaz, Cassandra Tierney, Kaarthik John, Jenny Valentine, Timothy Lockman, Hsing-Yin Liu, Benjamin Moritz, Jean Paul Ouedraogo, Marie-Soleil Piche, Muriel Smet, Jacqueline Murphy, Kaylyn Koenig, Agnes Zybura, Carrie Vyhlidal, Jonathan Mercier, Niketa Jani, Mikael Kubista, Donald Birch, Karlin Morse, Oskar Johansson
The emerging use of qPCR and dPCR in regulated bioanalysis and absence of regulatory guidance on assay validations for these platforms has resulted in discussions on lack of harmonization on assay design and appropriate acceptance criteria for these assays. Both qPCR and dPCR are extensively used to answer bioanalytical questions for novel modalities such as cell and gene therapies. Following cross-industry conversations on the lack of information and guidelines for these assays, an American Association of Pharmaceutical Scientists working group was formed to address these gaps by bringing together 37 industry experts from 24 organizations to discuss best practices to gain a better understanding in the industry and facilitate filings to health authorities...
February 5, 2024: AAPS Journal
#35
JOURNAL ARTICLE
Rodabe Amaria, Anne Knisely, David Vining, Scott Kopetz, Michael J Overman, Milind Javle, Mara B Antonoff, Ching-Wei D Tzeng, Robert A Wolff, Shubham Pant, Kathryn Lito, Kelly Rangel, Bryan Fellman, Ying Yuan, Karen H Lu, Donastas Sakellariou-Thompson, Cara L Haymaker, Marie-Andrée Forget, Patrick Hwu, Chantale Bernatchez, Amir A Jazaeri
BACKGROUND: Tumor-infiltrating lymphocyte (TIL) therapy has shown efficacy in metastatic melanoma, non-small cell lung cancer, and other solid tumors. Our preclinical work demonstrated more robust CD8 predominant TIL production when agonistic anti-4-1BB and CD3 antibodies were used in early ex vivo TIL culture. METHODS: Patients with treatment-refractory metastatic colorectal (CRC), pancreatic (PDAC) and ovarian (OVCA) cancers were eligible. Lymphodepleting chemotherapy was followed by infusion of ex vivo expanded TIL, manufactured at MD Anderson Cancer Center with IL-2 and agonistic stimulation of CD3 and 4-1BB (urelumab)...
February 2, 2024: Journal for Immunotherapy of Cancer
#36
EDITORIAL
Kyle N Kunze, Riley J Williams, Anil S Ranawat, Andrew D Pearle, Bryan T Kelly, Jon Karlsson, R Kyle Martin, Ayoosh Pareek
No abstract text is available yet for this article.
January 2024: Knee Surgery, Sports Traumatology, Arthroscopy
#37
JOURNAL ARTICLE
Julie M Fritz, Bryan Gibson, David W Wetter, Guilherme Del Fiol, Victor Solis, Isaac Ford, Kelly Lundberg, Anne Thackeray
BACKGROUND: Considerable disparities in chronic pain management have been identified. Persons in rural, lower income, and minoritized communities are less likely to receive evidence-based, nonpharmacologic care. Telehealth delivery of nonpharmacologic, evidence-based interventions for persons with chronic pain is a promising strategy to lessen disparities, but implementation comes with many challenges. The BeatPain Utah study is a hybrid type 1 effectiveness-implementation pragmatic clinical trial investigating telehealth strategies to provide nonpharmacologic care from physical therapists to persons with chronic back pain receiving care in ommunity health centers (CHCs)...
January 5, 2024: Implementation science communications
#38
JOURNAL ARTICLE
Elizabeth M Keating, Francis Sakita, Maddy Vonderohe, Getrude Nkini, Ismail Amiri, Kelly Loutzenheiser, Bryan Young, Sharla Rent, Catherine A Staton, Blandina T Mmbaga, Melissa H Watt
BACKGROUND: Pediatric injuries are a leading cause of morbidity and mortality in low- and middle-income countries (LMICs). It is important that injured children get quality care in order to improve their outcomes. Injured children are nearly always accompanied by family member caregivers invested in their outcome, and who will be responsible for their recovery and rehabilitation after discharge. OBJECTIVE: The purpose of this study was to identify family member caregiver perspectives on strengths and challenges in pediatric injury care throughout hospitalization at a tertiary hospital in Northern Tanzania...
2023: PloS One
#39
JOURNAL ARTICLE
Daniel B Reeves, Bryan T Mayer, Allan C deCamp, Yunda Huang, Bo Zhang, Lindsay N Carpp, Craig A Magaret, Michal Juraska, Peter B Gilbert, David C Montefiori, Katharine J Bar, E Fabian Cardozo-Ojeda, Joshua T Schiffer, Raabya Rossenkhan, Paul Edlefsen, Lynn Morris, Nonhlanhla N Mkhize, Carolyn Williamson, James I Mullins, Kelly E Seaton, Georgia D Tomaras, Philip Andrew, Nyaradzo Mgodi, Julie E Ledgerwood, Myron S Cohen, Lawrence Corey, Logashvari Naidoo, Catherine Orrell, Paul A Goepfert, Martin Casapia, Magdalena E Sobieszczyk, Shelly T Karuna, Srilatha Edupuganti
The Antibody Mediated Prevention (AMP) trials (NCT02716675 and NCT02568215) demonstrated that passive administration of the broadly neutralizing monoclonal antibody VRC01 could prevent some HIV-1 acquisition events. Here, we use mathematical modeling in a post hoc analysis to demonstrate that VRC01 influenced viral loads in AMP participants who acquired HIV. Instantaneous inhibitory potential (IIP), which integrates VRC01 serum concentration and VRC01 sensitivity of acquired viruses in terms of both IC50 and IC80, follows a dose-response relationship with first positive viral load (p = 0...
December 14, 2023: Nature Communications
#40
Jaimie L Bryan, Lisa R Spiguel, Kelly M Herremans, Sabrina H Han, Jordan A McKean, Sarah Sorice-Virk
Chest masculinization is the most common surgery performed in transgender men, and although incidence of occult cancer is lower than in cis-gender women receiving mastectomy or reduction mammoplasties, the incidence of high-risk lesions is comparable. In patients with concerns for occult malignancy, Magtrace is a nonradioactive tracer available to assist management for its delayed sentinel lymph node mapping capabilities. We present the first case report using Magtrace before masculinizing mastectomies in a transgender man...
December 2023: Plastic and Reconstructive Surgery. Global Open
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