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Bryan Kelly

Benedict U Nwachukwu, Kara Fields, Brenda Chang, Danyal H Nawabi, Bryan T Kelly, Anil S Ranawat
BACKGROUND: There is increasing interest in defining meaningful improvement in patient-reported outcomes. Knowledge of the thresholds and determinants for successful femoroacetabular impingement (FAI) outcomes is evolving. PURPOSE: To define preoperative outcome score thresholds and determine clinical/demographic patient factors predictive for achieving the minimal clinically important difference (MCID) after arthroscopic FAI surgery. STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 2...
October 20, 2016: American Journal of Sports Medicine
Charles F Haines, John A Fleishman, Baligh R Yehia, Bryan Lau, Stephen A Berry, Allison L Agwu, Richard D Moore, Kelly A Gebo
BACKGROUND: In the current antiretroviral (ART) era, the evolution of HIV guidelines and emergence of new ART agents might be expected to impact the times to ART initiation and HIV virologic suppression. We sought to determine if times to AI and virologic suppression decreased and if disparities exist by age, race/ethnicity, and HIV risk. METHODS: We performed a retrospective cohort study of data from 12 sites of the HIV Research Network, a consortium of US clinics caring for HIV-infected patients...
November 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Bryan P Fitzgerald, Kelly M Conn, Joanne Smith, Andrew Walker, Amy L Parkhill, James E Hilbert, Elizabeth A Luebbe, Richard T Moxley Iii
Myotonic dystrophy (DM) and facioscapulohumeral muscular dystrophy (FSHD) are the two most common adult muscular dystrophies and have progressive and often disabling manifestations. Higher levels of medication adherence lead to better health outcomes, especially important to patients with DM and FSHD because of their multisystem manifestations and complexity of care. However, medication adherence has not previously been studied in a large cohort of DM type 1 (DM1), DM type 2 (DM2), and FSHD patients. The purpose of our study was to survey medication adherence and disease manifestations in patients enrolled in the NIH-supported National DM and FSHD Registry...
October 12, 2016: Journal of Neurology
Corrado Cancedda, Sheila M Davis, Kerry L Dierberg, Jonathan Lascher, J Daniel Kelly, Mohammed Bailor Barrie, Alimamy Philip Koroma, Peter George, Adikali Alpha Kamara, Ronald Marsh, Manso S Sumbuya, Cameron T Nutt, Kirstin W Scott, Edgar Thomas, Katherine Bollbach, Andrew Sesay, Ahmidu Barrie, Elizabeth Barrera, Kathryn Barron, John Welch, Nahid Bhadelia, Raphael G Frankfurter, Ophelia M Dahl, Sarthak Das, Rebecca E Rollins, Bryan Eustis, Amanda Schwartz, Piero Pertile, Ilias Pavlopoulos, Allan Mayfield, Regan H Marsh, Yusupha Dibba, Danielle Kloepper, Andrew Hall, Karin Huster, Michael Grady, Kimberly Spray, David A Walton, Fodei Daboh, Cora Nally, Sahr James, Gabriel S Warren, Joyce Chang, Michael Drasher, Gina Lamin, Sherry Bangura, Ann C Miller, Annie P Michaelis, Ryan McBain, M Jana Broadhurst, Megan Murray, Eugene T Richardson, Ted Philip, Gary L Gottlieb, Joia S Mukherjee, Paul E Farmer
An epidemic of Ebola virus disease (EVD) beginning in 2013 has claimed an estimated 11 310 lives in West Africa. As the EVD epidemic subsides, it is important for all who participated in the emergency Ebola response to reflect on strengths and weaknesses of the response. Such reflections should take into account perspectives not usually included in peer-reviewed publications and after-action reports, including those from the public sector, nongovernmental organizations (NGOs), survivors of Ebola, and Ebola-affected households and communities...
October 15, 2016: Journal of Infectious Diseases
Bryan King, Francesco Boccalatte, Kelly Moran-Crusio, Elmar Wolf, Jingjing Wang, Clarisse Kayembe, Charalampos Lazaris, Xiaofeng Yu, Beatriz Aranda-Orgilles, Anna Lasorella, Iannis Aifantis
Hematopoietic stem cells (HSCs) are dormant in the bone marrow and can be activated in response to diverse stresses to replenish all blood cell types. We identified the ubiquitin ligase Huwe1 as a crucial regulator of HSC function via its post-translational control of the oncoprotein N-myc (encoded by Mycn). We found Huwe1 to be essential for HSC self-renewal, quiescence and lymphoid-fate specification in mice. Through the use of a fluorescent fusion allele (Mycn(M)), we observed that N-myc expression was restricted to the most immature, multipotent stem and progenitor populations...
September 26, 2016: Nature Immunology
Bryan W Tillman, Jeremy Kelly, Tara D Richards, Alex F Chen, Albert D Donnenberg, Vera S Donnenberg, Edith Tzeng
OBJECTIVE: Vascular restenosis remains a major obstacle to long-term success after vascular intervention. Circulating progenitor cells have been implicated in restenosis, and yet it has remained unclear if these cells, particularly nonendothelial progenitors, have an active role in this pathologic process. We hypothesized that circulating CD34(+)/c-kit(+) progenitors would increase after vascular injury, mirrored by changes in the injury signal, stromal cell-derived factor 1α (sdf1α)...
October 2016: Journal of Vascular Surgery
Susan E Spratt, Katherine Pereira, Bradi B Granger, Bryan C Batch, Matthew Phelan, Michael Pencina, Marie Lynn Miranda, Ebony Boulware, Joseph E Lucas, Charlotte L Nelson, Benjamin Neely, Benjamin A Goldstein, Pamela Barth, Rachel L Richesson, Isaretta L Riley, Leonor Corsino, Eugenia R McPeek Hinz, Shelley Rusincovitch, Jennifer Green, Anna Beth Barton, Carly Kelley, Kristen Hyland, Monica Tang, Amanda Elliott, Ewa Ruel, Alexander Clark, Melanie Mabrey, Kay Lyn Morrissey, Jyothi Rao, Beatrice Hong, Marjorie Pierre-Louis, Katherine Kelly, Nicole Jelesoff
OBJECTIVE: We assessed the sensitivity and specificity of 8 electronic health record (EHR)-based phenotypes for diabetes mellitus against gold-standard American Diabetes Association (ADA) diagnostic criteria via chart review by clinical experts. MATERIALS AND METHODS: We identified EHR-based diabetes phenotype definitions that were developed for various purposes by a variety of users, including academic medical centers, Medicare, the New York City Health Department, and pharmacy benefit managers...
September 11, 2016: Journal of the American Medical Informatics Association: JAMIA
Adam P Goode, Katherine S Hall, Bryan C Batch, Kim M Huffman, S Nicole Hastings, Kelli D Allen, Ryan J Shaw, Frances A Kanach, Jennifer R McDuffie, Andrzej S Kosinski, John W Williams, Jennifer M Gierisch
BACKGROUND: Regular physical activity is important for improving and maintaining health, but sedentary behavior is difficult to change. Providing objective, real-time feedback on physical activity with wearable motion-sensing technologies (activity monitors) may be a promising, scalable strategy to increase physical activity or decrease weight. PURPOSE: We synthesized the literature on the use of wearable activity monitors for improving physical activity and weight-related outcomes and evaluated moderating factors that may have an impact on effectiveness...
August 26, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Kate Buchacz, Bryan Lau, Yuezhou Jing, Ronald Bosch, Alison G Abraham, M John Gill, Michael J Silverberg, James J Goedert, Timothy R Sterling, Keri N Althoff, Jeffrey N Martin, Greer Burkholder, Neel Gandhi, Hasina Samji, Pragna Patel, Anita Rachlis, Jennifer E Thorne, Sonia Napravnik, Keith Henry, Angel Mayor, Kelly Gebo, Stephen J Gange, Richard D Moore, John T Brooks
BACKGROUND: There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada. METHODS: We studied HIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21%) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed incident OIs among the remaining 63 541 persons, most of whom received antiretroviral therapy during the observation...
September 15, 2016: Journal of Infectious Diseases
Stephen C Haskins, Natasha A Desai, Kara G Fields, Jemiel A Nejim, Stephanie Cheng, Struan H Coleman, Danyal H Nawabi, Bryan T Kelly
BACKGROUND: Intraabdominal fluid extravasation (IAFE) after hip arthroscopy has historically been diagnosed in catastrophic circumstances with abdominal compartment syndrome requiring diuresis or surgical decompression. A previous retrospective study found the prevalence of symptomatic IAFE requiring diuresis or decompression to be 0.16%, with risk factors including surgical procedure and high pump pressures. IAFE can be diagnosed rapidly by using point-of-care ultrasound (POCUS) via the Focused Assessment With Sonography for Trauma (FAST) examination, which is a well-established means to detect free fluid with high specificity and sensitivity...
August 22, 2016: Anesthesia and Analgesia
Ryan M Degen, Kara G Fields, C Sally Wentzel, Bethanne Bartscherer, Anil Ranawat, Struan H Coleman, Bryan T Kelly
INTRODUCTION: Femoroacetabular impingement (FAI) has been increasingly recognized in cutting sports including soccer, hockey and football. More recently, the prevalence among overhead athletes has also been recognized. The purpose of this study was to review impingement patterns, return-to-play rates and clinical outcome following arthroscopic treatment of FAI among high-level baseball players. METHODS: Between 2010 and 2014, 70 competitive baseball players (86 hips; age 22...
August 19, 2016: Physician and Sportsmedicine
Christopher Kweon, K Linnea Welton, Bryan T Kelly, Christopher M Larson, Asheesh Bedi
No abstract text is available yet for this article.
September 15, 2015: JBJS Rev
Eileen A Crawford, K Linnea Welton, Christopher Kweon, Bryan T Kelly, Christopher M Larson, Asheesh Bedi
No abstract text is available yet for this article.
August 25, 2015: JBJS Rev
Benjamin F Ricciardi, Stephanie W Mayer, Kara G Fields, Catherine Wentzel, Bryan T Kelly, Ernest L Sink
BACKGROUND: Symptomatic labral tears are common in patients with acetabular dysplasia; however, optimal treatment of the labrum remains controversial. PURPOSE: To present patient characteristics and early functional outcomes associated with combined arthroscopic labral refixation and Bernese periacetabular osteotomy (PAO) for symptomatic acetabular dysplasia with a displaced labral tear from the acetabular rim. STUDY DESIGN: Cohort study; Level of evidence, 3...
July 14, 2016: American Journal of Sports Medicine
Jordan Debono, Chip Cochran, Sanjaya Kuruppu, Amanda Nouwens, Niwanthi W Rajapakse, Minami Kawasaki, Kelly Wood, James Dobson, Kate Baumann, Mahdokht Jouiaei, Timothy N W Jackson, Ivan Koludarov, Dolyce Low, Syed A Ali, A Ian Smith, Andrew Barnes, Bryan G Fry
Central and South American pitvipers, belonging to the genera Bothrops and Bothriechis, have independently evolved arboreal tendencies. Little is known regarding the composition and activity of their venoms. In order to close this knowledge gap, venom proteomics and toxin activity of species of Bothriechis, and Bothrops (including Bothriopsis) were investigated through established analytical methods. A combination of proteomics and bioactivity techniques was used to demonstrate a similar diversification of venom composition between large and small species within Bothriechis and Bothriopsis...
2016: Toxins
Michael J McGeachie, Katherine P Yates, Xiaobo Zhou, Feng Guo, Alice L Sternberg, Mark L Van Natta, Robert A Wise, Stanley J Szefler, Sunita Sharma, Alvin T Kho, Michael H Cho, Damien C Croteau-Chonka, Peter J Castaldi, Gaurav Jain, Amartya Sanyal, Ye Zhan, Bryan R Lajoie, Job Dekker, John Stamatoyannopoulos, Ronina A Covar, Robert S Zeiger, N Franklin Adkinson, Paul V Williams, H William Kelly, Hartmut Grasemann, Judith M Vonk, Gerard H Koppelman, Dirkje S Postma, Benjamin A Raby, Isaac Houston, Quan Lu, Anne L Fuhlbrigge, Kelan G Tantisira, Edwin K Silverman, James Tonascia, Robert C Strunk, Scott T Weiss
RATIONALE: Patterns of longitudinal lung function growth and decline in childhood asthma have been shown to be important in determining risk for future respiratory ailments including chronic airway obstruction and chronic obstructive pulmonary disease (COPD). OBJECTIVES: To determine the genetic underpinnings of lung function patterns in childhood asthmatics. METHODS: We performed a genome-wide association study of 581 non-Hispanic white asthmatics that were previously classified by patterns of lung function growth and decline, (Normal Growth, Normal Growth with Early Decline, Reduced Growth, and Reduced Growth with Early Decline)...
July 1, 2016: American Journal of Respiratory and Critical Care Medicine
David T Kelly, Cathal J Cregg, Paul L O'Connor, Bryan D Cullen, Niall M Moyna
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
David M Levy, Benjamin D Kuhns, Jaskarndip Chahal, Marc J Philippon, Bryan T Kelly, Shane J Nho
PURPOSE: To determine whether the hip arthroscopy literature to date has shown outcomes consistent with published patient acceptable symptomatic state (PASS) and minimal clinically important difference (MCID) estimates. METHODS: All clinical investigations of hip arthroscopy using modified Harris Hip Score (mHHS) and/or Hip Outcome Score (HOS) outcomes with at least 1 year of follow-up were reviewed. Ninety-one studies (9,746 hips) were included for review. Eighty-one studies (9,317 hips) contained only primary hip arthroscopies and were the primary focus of this review...
September 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
Rahman Shah, Kelly C Rogers, Agha J Ahmed, Bryan J King, Sunil V Rao
OBJECTIVES: The aim of this study was to evaluate the efficacy of various doses of post-primary percutaneous coronary intervention (PCI) bivalirudin infusion to prevent acute stent thrombosis (AST). BACKGROUND: In several recent randomized controlled trials, bivalirudin infusion was continued post-PCI as either a full PCI dose (Biv-Full) or a reduced dose (Biv-Low) to reduce the risk for AST. The results of these trials varied, so the authors performed a meta-analysis of RCTs to determine whether the risk for AST is dose dependent...
July 11, 2016: JACC. Cardiovascular Interventions
Andrew W Kuhn, Benjamin C Noonan, Bryan T Kelly, Christopher M Larson, Asheesh Bedi
Ice hockey is a fast, physical sport with unique associated biomechanical demands often placing the hip in forced and repetitive supraphysiological ranges of motion. Ice hockey players commonly endure and are sidelined by nebulous groin injury or hip pain. Underlying causes can be chronic or acute and extra-articular, intra-articular, or "hip-mimicking." This article serves to review common hip-related injuries in ice hockey. For each, we define the particular condition; comment on risk factors and preventive strategies; discuss key historical, physical examination, and imaging findings; and finally, suggest nonoperative and/or operative treatment plans...
September 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
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