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JOURNAL ARTICLE
H Jesse Smith, Ian S Osbourne, Mattia Maroso, Di Jiang, Phil Szuromi, L Bryan Ray, Jelena Stajic, Orla Smith, Priscilla N Kelly, Ekeoma Uzogara, Marc S Lavine, Caroline Ash, Christiana N Fogg, Leslie K Ferrarelli, Yevgeniya Nusinovich
Highlights from the Science family of journals.
May 3, 2024: Science
#2
REVIEW
Wendy J Shaw, Michelle K Kidder, Simon R Bare, Massimiliano Delferro, James R Morris, Francesca M Toma, Sanjaya D Senanayake, Tom Autrey, Elizabeth J Biddinger, Shannon Boettcher, Mark E Bowden, Phillip F Britt, Robert C Brown, R Morris Bullock, Jingguang G Chen, Claus Daniel, Peter K Dorhout, Rebecca A Efroymson, Kelly J Gaffney, Laura Gagliardi, Aaron S Harper, David J Heldebrant, Oana R Luca, Maxim Lyubovsky, Jonathan L Male, Daniel J Miller, Tanya Prozorov, Robert Rallo, Rachita Rana, Robert M Rioux, Aaron D Sadow, Joshua A Schaidle, Lisa A Schulte, William A Tarpeh, Dionisios G Vlachos, Bryan D Vogt, Robert S Weber, Jenny Y Yang, Elke Arenholz, Brett A Helms, Wenyu Huang, James L Jordahl, Canan Karakaya, Kourosh Cyrus Kian, Jotheeswari Kothandaraman, Johannes Lercher, Ping Liu, Deepika Malhotra, Karl T Mueller, Casey P O'Brien, Robert M Palomino, Long Qi, José A Rodriguez, Roger Rousseau, Jake C Russell, Michele L Sarazen, David S Sholl, Emily A Smith, Michaela Burke Stevens, Yogesh Surendranath, Christopher J Tassone, Ba Tran, William Tumas, Krista S Walton
Electrification to reduce or eliminate greenhouse gas emissions is essential to mitigate climate change. However, a substantial portion of our manufacturing and transportation infrastructure will be difficult to electrify and/or will continue to use carbon as a key component, including areas in aviation, heavy-duty and marine transportation, and the chemical industry. In this Roadmap, we explore how multidisciplinary approaches will enable us to close the carbon cycle and create a circular economy by defossilizing these difficult-to-electrify areas and those that will continue to need carbon...
May 1, 2024: Nature Reviews. Chemistry
#3
JOURNAL ARTICLE
Susan Rowell, Eric N Meier, Tatiana Hoyos Gomez, Michael Fleming, Jon Jui, Laurie Morrison, Eileen Bulger, George Sopko, Myron Weisfeldt, Jim Christenson, Pat Klotz, Jason McMullan, Jeannie Callum, Kellie Sheehan, Brian Tibbs, Tom Aufderheide, Bryan Cotton, Rajesh Gandhi, Ahamed Idris, Ralph J Frascone, Michael Ferrara, Neil Richmond, Delores Kannas, Rob Schlamp, Bryce Robinson, David Dries, John Tallon, Audrey Hendrickson, Mark Gamber, John Garrett, Robert Simonson, W Ian McKinley, Martin Schreiber
BACKGROUND: In the Prehospital Tranexamic Acid (TXA) for TBI Trial, TXA administered within two hours of injury in the out-of-hospital setting did not reduce mortality in all patients with moderate/severe traumatic brain injury (TBI). We examined the association between TXA dosing arms, neurologic outcome, and mortality in patients with intracranial hemorrhage (ICH) on computed tomography (CT). METHODS: This was a secondary analysis of the Prehospital Tranexamic Acid for TBI Trial (ClinicalTrials...
April 30, 2024: Journal of Trauma and Acute Care Surgery
#4
JOURNAL ARTICLE
Anand Maligireddy, Ahmad Jabri, Mohammad Zghouzi, Chaitanya Rojulpote, Gabriella VanAken, Chaitra Janga, Ryhm Radjef, Herbert Aronow, Rana Awdish, Bryan Kelly, Gillian Grafton, Timir K Paul, Chien-Jung Lin, Deana Mikhalkova, Khaldoon Alaswad, Domingo Franco-Palacios, Pedro Villablanca, Vikas Aggarwal
BACKGROUND: Pulmonary hypertension (PH) disproportionately affects women, presenting challenges during pregnancy. Historically, patients with PH are advised to avoid pregnancy; however, recent reports have indicated that the incidence of adverse events in pregnant females with PH may be lower than previously reported. METHODS: We conducted a retrospective cohort study in pregnant patients with PH using the National Readmission Database from January 1, 2016, to December 31, 2020...
April 23, 2024: American Journal of Cardiology
#5
JOURNAL ARTICLE
J Sebastian Garcia-Medina, Karolina Sienkiewicz, S Anand Narayanan, Eliah G Overbey, Kirill Grigorev, Krista A Ryon, Marissa Burke, Jacqueline Proszynski, Braden Tierney, Caleb M Schmidt, Nuria Mencia-Trinchant, Remi Klotz, Veronica Ortiz, Jonathan Foox, Christopher Chin, Deena Najjar, Irina Matei, Irenaeus Chan, Carlos Cruchaga, Ashley Kleinman, JangKeun Kim, Alexander Lucaci, Conor Loy, Omary Mzava, Iwijn De Vlaminck, Anvita Singaraju, Lynn E Taylor, Julian C Schmidt, Michael A Schmidt, Kelly Blease, Juan Moreno, Andrew Boddicker, Junhua Zhao, Bryan Lajoie, Andrew Altomare, Semyon Kruglyak, Shawn Levy, Min Yu, Duane C Hassane, Susan M Bailey, Kelly Bolton, Jaime Mateus, Christopher E Mason
BACKGROUND: The Inspiration4 (I4) mission, the first all-civilian orbital flight mission, investigated the physiological effects of short-duration spaceflight through a multi-omic approach. Despite advances, there remains much to learn about human adaptation to spaceflight's unique challenges, including microgravity, immune system perturbations, and radiation exposure. METHODS: To provide a detailed genetics analysis of the mission, we collected dried blood spots pre-, during, and post-flight for DNA extraction...
March 2024: Precision Clinical Medicine
#6
JOURNAL ARTICLE
Quyen B Do, Humaira Noor, Ricardo Marquez-Gomez, Kaitlyn M L Cramb, Bryan Ng, Ajantha Abbey, Naroa Ibarra-Aizpurua, Maria Claudia Caiazza, Parnaz Sharifi, Charmaine Lang, Dayne Beccano-Kelly, Jimena Baleriola, Nora Bengoa-Vergniory, Richard Wade-Martins
Understanding medium spiny neuron (MSN) physiology is essential to understand motor impairments in Parkinson's disease (PD) given the architecture of the basal ganglia. Here, we developed a custom three-chambered microfluidic platform and established a cortico-striato-nigral microcircuit partially recapitulating the striatal presynaptic landscape in vitro using induced pluripotent stem cell (iPSC)-derived neurons. We found that, cortical glutamatergic projections facilitated MSN synaptic activity, and dopaminergic transmission enhanced maturation of MSNs in vitro...
April 12, 2024: NPJ Parkinson's Disease
#7
JOURNAL ARTICLE
Karuna Mittal, Garrett W Cooper, Benjamin P Lee, Yongdong Su, Katie T Skinner, Jenny Shim, Hunter C Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D Kynnap, Amanda L Christie, Xiaoping Yang, Glenn S Cowley, Brittaney A Leeper, Christopher L Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M Clinton, Manoj Bhasin, Brian D Crompton, Yuen-Yi Tseng, Jesse S Boehm, Keith L Ligon, David E Root, Andrew J Murphy, David M Weinstock, Prafulla C Gokhale, Jennifer M Spangle, Miguel N Rivera, Elizabeth A Mullen, Kimberly Stegmaier, Kelly C Goldsmith, William C Hahn, Andrew L Hong
Wilms tumor (WT) is the most common renal malignancy of childhood. Despite improvements in the overall survival, relapse occurs in ~15% of patients with favorable histology WT (FHWT). Half of these patients will succumb to their disease. Identifying novel targeted therapies remains challenging in part due to the lack of faithful preclinical in vitro models. Here we establish twelve patient-derived WT cell lines and demonstrate that these models faithfully recapitulate WT biology using genomic and transcriptomic techniques...
April 8, 2024: Communications Biology
#8
JOURNAL ARTICLE
Joshua N Speirs, Stefan Parent, Michael Kelly, Vidyadhar V Upasani, Maty Petcharaporn, Tracey P Bryan, Peter O Newton
PURPOSE: To evaluate three-dimensional (3D) vertebra and disk shape changes over 2 years following anterior vertebral body tether (AVBT) placement in patients with idiopathic scoliosis (IS). METHODS: Patients with right thoracic IS treated with AVBT were retrospectively evaluated. 3D reconstructions were created from biplanar radiographs. Vertebral body and disk height (anterior, posterior, left and right) and shape (wedging angle) were recorded over the three apical segments in the local vertebral reference planes...
April 5, 2024: Spine Deformity
#9
JOURNAL ARTICLE
Kelly E Sanders, Gabrielle E Hatton, Atharwa R Mankame, Addison C Allen, Sarah Cunningham, Jan Michael Van Gent, Erin E Fox, Xu Zhang, Charles E Wade, Bryan A Cotton, Jessica C Cardenas
INTRODUCTION: Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in trauma patients, despite chemoprophylaxis. Statins have been shown capable of acting upon the endothelium. We hypothesized that statin therapy in the pre- or in-hospital settings leads to a decreased incidence of VTE. METHODS: We conducted a retrospective cohort study of injured patients who received statin therapy pre- or in-hospital. Adult, highest-level trauma activation patients admitted January 2018 - June 2022 were included...
March 25, 2024: Journal of Trauma and Acute Care Surgery
#10
Daniel B Reeves, Bryan T Mayer, Allan C deCamp, Yunda Huang, Bo Zhang, Lindsay N Carpp, Craig A Magaret, Michal Juraska, Peter B Gilbert, David C Montefiori, Katharine J Bar, E Fabian Cardozo-Ojeda, Joshua T Schiffer, Raabya Rossenkhan, Paul Edlefsen, Lynn Morris, Nonhlanhla N Mkhize, Carolyn Williamson, James I Mullins, Kelly E Seaton, Georgia D Tomaras, Philip Andrew, Nyaradzo Mgodi, Julie E Ledgerwood, Myron S Cohen, Lawrence Corey, Logashvari Naidoo, Catherine Orrell, Paul A Goepfert, Martin Casapia, Magdalena E Sobieszczyk, Shelly T Karuna, Srilatha Edupuganti
No abstract text is available yet for this article.
March 22, 2024: Nature Communications
#11
JOURNAL ARTICLE
Jessica A Griffiths, Bryan B Yoo, Peter Thuy-Boun, Victor J Cantu, Kelly C Weldon, Collin Challis, Michael J Sweredoski, Ken Y Chan, Taren M Thron, Gil Sharon, Annie Moradian, Gregory Humphrey, Qiyun Zhu, Justin P Shaffer, Dennis W Wolan, Pieter C Dorrestein, Rob Knight, Viviana Gradinaru, Sarkis K Mazmanian
The gastrointestinal (GI) tract is innervated by intrinsic neurons of the enteric nervous system (ENS) and extrinsic neurons of the central nervous system and peripheral ganglia. The GI tract also harbors a diverse microbiome, but interactions between the ENS and the microbiome remain poorly understood. Here, we activate choline acetyltransferase (ChAT)-expressing or tyrosine hydroxylase (TH)-expressing gut-associated neurons in mice to determine effects on intestinal microbial communities and their metabolites as well as on host physiology...
March 21, 2024: Cell Reports
#12
JOURNAL ARTICLE
Eileen L McLellan, Kelly M Suttles, Kristen L Bouska, Jamelle H Ellis, Joseph E Flotemersch, Madison Goff, Heather E Golden, Ryan A Hill, Tara R Hohman, Shamitha Keerthi, Richard F Keim, Barbara A Kleiss, Tyler J Lark, Bryan P Piazza, Alisha A Renfro, Dale M Robertson, Keith E Schilling, Travis S Schmidt, Ian R Waite
Continued large-scale public investment in declining ecosystems depends on demonstrations of "success". While the public conception of "success" often focuses on restoration to a pre-disturbance condition, the scientific community is more likely to measure success in terms of improved ecosystem health. Using a combination of literature review, workshops and expert solicitation we propose a generalized framework to improve ecosystem health in highly altered river basins by reducing ecosystem stressors, enhancing ecosystem processes and increasing ecosystem resilience...
February 22, 2024: Frontiers in Environmental Science
#13
JOURNAL ARTICLE
Omar F Rahman, Kyle N Kunze, Kaisen Yao, Susan Y Kwiecien, Anil S Ranawat, Michael B Banffy, Bryan T Kelly, Gregory J Galano
PURPOSE: To (1) compare the efficacy of immersive virtual reality (iVR) to nonimmersive virtual reality (non-iVR) training in hip arthroscopy on procedural and knowledge-based skills acquisition and (2) evaluate the relative cost of each platform. METHODS: Fourteen orthopaedic surgery residents were randomized to simulation training utilizing an iVR Hip Arthroscopy Simulator (n = 7; PrecisionOS) or non-iVR simulator (n = 7; ArthroS Hip VR; VirtaMed). After training, performance was assessed on a cadaver by 4 expert hip arthroscopists through arthroscopic video review of a diagnostic hip arthroscopy...
March 19, 2024: Arthroscopy
#14
JOURNAL ARTICLE
Hermaleigh Townsley, Joshua Gahir, Timothy W Russell, David Greenwood, Edward J Carr, Matala Dyke, Lorin Adams, Murad Miah, Bobbi Clayton, Callie Smith, Mauro Miranda, Harriet V Mears, Chris Bailey, James R M Black, Ashley S Fowler, Margaret Crawford, Katalin Wilkinson, Matthew Hutchinson, Ruth Harvey, Nicola O'Reilly, Gavin Kelly, Robert Goldstone, Rupert Beale, Padmasayee Papineni, Tumena Corrah, Richard Gilson, Simon Caidan, Jerome Nicod, Steve Gamblin, George Kassiotis, Vincenzo Libri, Bryan Williams, Sonia Gandhi, Adam J Kucharski, Charles Swanton, David L V Bauer, Emma C Wall
BACKGROUND: SARS-CoV-2 variant Omicron rapidly evolved over 2022, causing three waves of infection due to sub-variants BA.1, BA.2 and BA.4/5. We sought to characterise symptoms and viral loads over the course of COVID-19 infection with these sub-variants in otherwise-healthy, vaccinated, non-hospitalised adults, and compared data to infections with the preceding Delta variant of concern (VOC). METHODS: In a prospective, observational cohort study, healthy vaccinated UK adults who reported a positive polymerase chain reaction (PCR) or lateral flow test, self-swabbed on alternate weekdays until day 10...
2024: PloS One
#15
JOURNAL ARTICLE
Deevyashali Parekh, Howard Lin, Akanksha Batajoo, Erin Peckham-Gregory, Vivekanudeep Karri, Whitney Stanton, Brooks Scull, Ryan Fleishmann, Nader El-Mallawany, Olive S Eckstein, Zachary D Prudowsky, Nitya Gulati, Jennifer E Agrusa, Asra Z Ahmed, Roland Chu, Matthew S Dietz, Stanton C Goldman, Michael D Hogarty, Hamayun Imran, Stefanos Intzes, Jenny M Kim, Lisa M Kopp, Carolyn Fein Levy, Philip Neff, Pallavi M Pillai, Bryan A Sisk, Deborah E Schiff, Angela D Trobaugh-Lotrario, Kelly Walkovich, Kenneth L McClain, Carl E Allen
Over 50% of patients with systemic LCH are not cured with front-line therapies, and data to guide salvage options are limited. We describe 58 patients with LCH who were treated with clofarabine. Clofarabine monotherapy was active against LCH in this cohort, including heavily pretreated patients with a systemic objective response rate of 92.6%, higher in children (93.8%) than adults (83.3%). BRAFV600E+ variant allele frequency in peripheral blood is correlated with clinical responses. Prospective multicentre trials are warranted to determine optimal dosing, long-term efficacy, late toxicities, relative cost and patient-reported outcomes of clofarabine compared to alternative LCH salvage therapy strategies...
March 19, 2024: British Journal of Haematology
#16
COMMENT
Carlo Pierpaoli, Amritha Nayak, Rakibul Hafiz, M Okan Irfanoglu, Gang Chen, Paul Taylor, Mark Hallett, Michael Hoa, Dzung Pham, Yi-Yu Chou, Anita D Moses, André J van der Merwe, Sara M Lippa, Carmen C Brewer, Chris K Zalewski, Cris Zampieri, L Christine Turtzo, Pashtun Shahim, Leighton Chan, Brian Moore, Lauren Stamps, Spencer Flynn, Julia Fontana, Swathi Tata, Jessica Lo, Mirella A Fernandez, Annie Lori-Joseph, Jesse Matsubara, Julie Goldberg, Thuy-Tien D Nguyen, Noa Sasson, Justine Lely, Bryan Smith, Kelly A King, Jennifer Chisholm, Julie Christensen, M Teresa Magone, Chantal Cousineau-Krieger, Louis M French, Simge Yonter, Sanaz Attaripour, Chen Lai
IMPORTANCE: US government personnel stationed internationally have reported anomalous health incidents (AHIs), with some individuals experiencing persistent debilitating symptoms. OBJECTIVE: To assess the potential presence of magnetic resonance imaging (MRI)-detectable brain lesions in participants with AHIs, with respect to a well-matched control group. DESIGN, SETTING, AND PARTICIPANTS: This exploratory study was conducted at the National Institutes of Health (NIH) Clinical Center and the NIH MRI Research Facility between June 2018 and November 2022...
April 2, 2024: JAMA
#17
JOURNAL ARTICLE
Leighton Chan, Mark Hallett, Chris K Zalewski, Carmen C Brewer, Cris Zampieri, Michael Hoa, Sara M Lippa, Edmond Fitzgibbon, Louis M French, Anita D Moses, André J van der Merwe, Carlo Pierpaoli, L Christine Turtzo, Simge Yonter, Pashtun Shahim, Brian Moore, Lauren Stamps, Spencer Flynn, Julia Fontana, Swathi Tata, Jessica Lo, Mirella A Fernandez, Annie-Lori Joseph, Jesse Matsubara, Julie Goldberg, Thuy-Tien D Nguyen, Noa Sasson, Justine Lely, Bryan Smith, Kelly A King, Jennifer Chisholm, Julie Christensen, M Teresa Magone, Chantal Cousineau-Krieger, Rakibul Hafiz, Amritha Nayak, Okan Irfanoglu, Sanaz Attaripour, Chen Lai, Wendy B Smith
IMPORTANCE: Since 2015, US government and related personnel have reported dizziness, pain, visual problems, and cognitive dysfunction after experiencing intrusive sounds and head pressure. The US government has labeled these anomalous health incidents (AHIs). OBJECTIVE: To assess whether participants with AHIs differ significantly from US government control participants with respect to clinical, research, and biomarker assessments. DESIGN, SETTING, AND PARTICIPANTS: Exploratory study conducted between June 2018 and July 2022 at the National Institutes of Health Clinical Center, involving 86 US government staff and family members with AHIs from Cuba, Austria, China, and other locations as well as 30 US government control participants...
March 18, 2024: JAMA
#18
JOURNAL ARTICLE
Daniel S Harrison, Erika J Sigman, Judy H Ch'ang, Aarti Sarwal, Abigale Celotto, Alexandra Malone, Ariel Nowicki, Ashley Martin, Bryan Boling, Christa O'Hana S Nobleza, Christopher Reeves, David M Greer, Diane McLaughlin, Elizabeth O'B Woods, Emmaculate Fields, Erica Perets, Gemi E Jannotta, Jennifer Mears, Kaitlyn Twomey, Kelly A Rath, Kelly Peronti, Krista M Garner, Matthew B Bevers, Nicholas A Morris, Paola Martinez, Sahar Zafar, Sarah Livesay, Sarah Wahlster, Thomas Lawson, Catherine S W Albin
OBJECTIVES: To define consensus entrustable professional activities (EPAs) for neurocritical care (NCC) advanced practice providers (APPs), establish validity evidence for the EPAs, and evaluate factors that inform entrustment expectations of NCC APP supervisors. DESIGN: A three-round modified Delphi consensus process followed by application of the EQual rubric and assessment of generalizability by clinicians not affiliated with academic medical centers. SETTING: Electronic surveys...
March 15, 2024: Critical Care Medicine
#19
JOURNAL ARTICLE
Irenaeus C C Chan, Alex Panchot, Evelyn Schmidt, Samantha McNulty, Brian J Wiley, Jie Liu, Kimberly Turner, Lea Moukarzel, Wendy S W Wong, Duc Tran, J Scott Beeler, Armel Landry Batchi-Bouyou, Mitchell J Machiela, Danielle M Karyadi, Benjamin J Krajacich, Junhua Zhao, Semyon Kruglyak, Bryan Lajoie, Shawn Levy, Minal Patel, Philip W Kantoff, Christopher E Mason, Daniel C Link, Todd E Druley, Konrad H Stopsack, Kelly L Bolton
MOTIVATION: The acquisition of somatic mutations in hematopoietic stem and progenitor stem cells (HSPCs) with resultant clonal expansion, termed clonal hematopoiesis (CH), is associated with increased risk of hematologic malignancies and other adverse outcomes. CH is generally present at low allelic fractions, but clonal expansion and acquisition of additional mutations leads to hematologic cancers in a small proportion of individuals. With high depth and high sensitivity sequencing, CH can be detected in most adults and its clonal trajectory mapped over time...
March 14, 2024: Bioinformatics
#20
JOURNAL ARTICLE
Han-Sol Park, Anna Yin, Caelan Barranta, John S Lee, Christopher A Caputo, Jaiprasath Sachithanandham, Maggie Li, Steve Yoon, Ioannis Sitaras, Anne Jedlicka, Yolanda Eby, Malathi Ram, Reinaldo E Fernandez, Owen R Baker, Aarthi G Shenoy, Giselle S Mosnaim, Yuriko Fukuta, Bela Patel, Sonya L Heath, Adam C Levine, Barry R Meisenberg, Emily S Spivak, Shweta Anjan, Moises A Huaman, Janis E Blair, Judith S Currier, James H Paxton, Jonathan M Gerber, Joann R Petrini, Patrick B Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L Hammitt, Catherine G Sutcliffe, Donald N Forthal, Martin S Zand, Edward R Cachay, Jay S Raval, Seble G Kassaye, Christi E Marshall, Anusha Yarava, Karen Lane, Nichol A McBee, Amy L Gawad, Nicky Karlen, Atika Singh, Daniel E Ford, Douglas A Jabs, Lawrence J Appel, David M Shade, Bryan Lau, Stephan Ehrhardt, Sheriza N Baksh, Janna R Shapiro, Jiangda Ou, Yu Bin Na, Maria D Knoll, Elysse Ornelas-Gatdula, Netzahualcóyotl Arroyo-Currás, Thomas J Gniadek, Patrizio Caturegli, Jinke Wu, Nelson Ndahiro, Michael J Betenbaugh, Alyssa Ziman, Daniel F Hanley, Arturo Casadevall, Shmuel Shoham, Evan M Bloch, Kelly A Gebo, Aaron Ar Tobian, Oliver Laeyendecker, Andrew Pekosz, Sabra L Klein, David J Sullivan
BACKGROUND COVID-19 convalescent plasma (CCP) viral specific antibody levels that translate into recipient post-transfusion antibody levels sufficient to prevent disease progression is not defined.METHODS This secondary analysis correlated donor and recipient antibody levels to hospitalization risk among unvaccinated, seronegative CCP recipients within the outpatient, double blind, randomized clinical trial that compared CCP to control plasma. The majority of COVID-19 CCP arm hospitalizations (15/17, 88%) occurred in this unvaccinated, seronegative subgroup...
March 14, 2024: JCI Insight
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