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Bryan Kelly

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https://www.readbyqxmd.com/read/27920671/proceedings-of-the-fourth-annual-deep-brain-stimulation-think-tank-a-review-of-emerging-issues-and-technologies
#1
Wissam Deeb, James J Giordano, Peter J Rossi, Alon Y Mogilner, Aysegul Gunduz, Jack W Judy, Bryan T Klassen, Christopher R Butson, Craig Van Horne, Damiaan Deny, Darin D Dougherty, David Rowell, Greg A Gerhardt, Gwenn S Smith, Francisco A Ponce, Harrison C Walker, Helen M Bronte-Stewart, Helen S Mayberg, Howard J Chizeck, Jean-Philippe Langevin, Jens Volkmann, Jill L Ostrem, Jonathan B Shute, Joohi Jimenez-Shahed, Kelly D Foote, Aparna Wagle Shukla, Marvin A Rossi, Michael Oh, Michael Pourfar, Paul B Rosenberg, Peter A Silburn, Coralie de Hemptine, Philip A Starr, Timothy Denison, Umer Akbar, Warren M Grill, Michael S Okun
This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome...
2016: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/27883049/mqc-a-heuristic-quality-control-metric-for-high-throughput-drug-combination-screening
#2
Lu Chen, Kelli Wilson, Ian Goldlust, Bryan T Mott, Richard Eastman, Mindy I Davis, Xiaohu Zhang, Crystal McKnight, Carleen Klumpp-Thomas, Paul Shinn, John Simmons, Mike Gormally, Sam Michael, Craig J Thomas, Marc Ferrer, Rajarshi Guha
Quality control (QC) metrics are critical in high throughput screening (HTS) platforms to ensure reliability and confidence in assay data and downstream analyses. Most reported HTS QC metrics are designed for plate level or single well level analysis. With the advent of high throughput combination screening there is a need for QC metrics that quantify the quality of combination response matrices. We introduce a predictive, interpretable, matrix-level QC metric, mQC, based on a mix of data-derived and heuristic features...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27870634/investigation-of-and-response-to-2-plague-cases-yosemite-national-park-california-usa-2015
#3
Mary Danforth, Mark Novak, Jeannine Petersen, Paul Mead, Luke Kingry, Matthew Weinburke, Danielle Buttke, Gregory Hacker, James Tucker, Michael Niemela, Bryan Jackson, Kerry Padgett, Kelly Liebman, Duc Vugia, Vicki Kramer
In August 2015, plague was diagnosed for 2 persons who had visited Yosemite National Park in California, USA. One case was septicemic and the other bubonic. Subsequent environmental investigation identified probable locations of exposure for each patient and evidence of epizootic plague in other areas of the park. Transmission of Yersinia pestis was detected by testing rodent serum, fleas, and rodent carcasses. The environmental investigation and whole-genome multilocus sequence typing of Y. pestis isolates from the patients and environmental samples indicated that the patients had been exposed in different locations and that at least 2 distinct strains of Y...
December 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27791238/complications-and-short-term-patient-outcomes-of-periacetabular-osteotomy-for-symptomatic-mild-hip-dysplasia
#4
Benjamin F Ricciardi, Kara G Fields, Catherine Wentzel, Danyal H Nawabi, Bryan T Kelly, Ernest L Sink
INTRODUCTION: The purpose of our study is to identify complications and early functional outcome scores in patients treated with periacetabular osteotomy (PAO) for mild acetabular dysplasia. METHODS: The study population consisted of patients from a single centre prospective hip registry undergoing PAO with mild acetabular dysplasia (LCEA ≥18° and ≤25°; n = 27 patients; Mild Dysplasia group). A comparison group of patients undergoing PAO with more severe acetabular dysplasia (lateral centre-edge angle [LCEA] ≤17°; n = 50 patients; Severe Dysplasia group) were included as a comparison cohort...
October 24, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/27765733/preoperative-outcome-scores-are-predictive-of-achieving-the-minimal-clinically-important-difference-after-arthroscopic-treatment-of-femoroacetabular-impingement
#5
Benedict U Nwachukwu, Kara Fields, Brenda Chang, Danyal H Nawabi, Bryan T Kelly, Anil S Ranawat
BACKGROUND: There is increasing interest in defining meaningful improvement in patient-reported outcomes. Knowledge of the thresholds and determinants for successful femoroacetabular impingement (FAI) outcomes is evolving. PURPOSE: To define preoperative outcome score thresholds and determine clinical/demographic patient factors predictive for achieving the minimal clinically important difference (MCID) after arthroscopic FAI surgery. STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 2...
October 20, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27763997/closing-the-gap-in-antiretroviral-initiation-and-viral-suppression-time-trends-and-racial-disparities
#6
Charles F Haines, John A Fleishman, Baligh R Yehia, Bryan Lau, Stephen A Berry, Allison L Agwu, Richard D Moore, Kelly A Gebo
BACKGROUND: In the current antiretroviral (ART) era, the evolution of HIV guidelines and emergence of new ART agents might be expected to impact the times to ART initiation and HIV virologic suppression. We sought to determine if times to AI and virologic suppression decreased and if disparities exist by age, race/ethnicity, and HIV risk. METHODS: We performed a retrospective cohort study of data from 12 sites of the HIV Research Network, a consortium of US clinics caring for HIV-infected patients...
November 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27734165/medication-adherence-in-patients-with-myotonic-dystrophy-and-facioscapulohumeral-muscular-dystrophy
#7
Bryan P Fitzgerald, Kelly M Conn, Joanne Smith, Andrew Walker, Amy L Parkhill, James E Hilbert, Elizabeth A Luebbe, Richard T Moxley Iii
Myotonic dystrophy (DM) and facioscapulohumeral muscular dystrophy (FSHD) are the two most common adult muscular dystrophies and have progressive and often disabling manifestations. Higher levels of medication adherence lead to better health outcomes, especially important to patients with DM and FSHD because of their multisystem manifestations and complexity of care. However, medication adherence has not previously been studied in a large cohort of DM type 1 (DM1), DM type 2 (DM2), and FSHD patients. The purpose of our study was to survey medication adherence and disease manifestations in patients enrolled in the NIH-supported National DM and FSHD Registry...
December 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27688219/strengthening-health-systems-while-responding-to-a-health-crisis-lessons-learned-by-a-nongovernmental-organization-during-the-ebola-virus-disease-epidemic-in-sierra-leone
#8
Corrado Cancedda, Sheila M Davis, Kerry L Dierberg, Jonathan Lascher, J Daniel Kelly, Mohammed Bailor Barrie, Alimamy Philip Koroma, Peter George, Adikali Alpha Kamara, Ronald Marsh, Manso S Sumbuya, Cameron T Nutt, Kirstin W Scott, Edgar Thomas, Katherine Bollbach, Andrew Sesay, Ahmidu Barrie, Elizabeth Barrera, Kathryn Barron, John Welch, Nahid Bhadelia, Raphael G Frankfurter, Ophelia M Dahl, Sarthak Das, Rebecca E Rollins, Bryan Eustis, Amanda Schwartz, Piero Pertile, Ilias Pavlopoulos, Allan Mayfield, Regan H Marsh, Yusupha Dibba, Danielle Kloepper, Andrew Hall, Karin Huster, Michael Grady, Kimberly Spray, David A Walton, Fodei Daboh, Cora Nally, Sahr James, Gabriel S Warren, Joyce Chang, Michael Drasher, Gina Lamin, Sherry Bangura, Ann C Miller, Annie P Michaelis, Ryan McBain, M Jana Broadhurst, Megan Murray, Eugene T Richardson, Ted Philip, Gary L Gottlieb, Joia S Mukherjee, Paul E Farmer
An epidemic of Ebola virus disease (EVD) beginning in 2013 has claimed an estimated 11 310 lives in West Africa. As the EVD epidemic subsides, it is important for all who participated in the emergency Ebola response to reflect on strengths and weaknesses of the response. Such reflections should take into account perspectives not usually included in peer-reviewed publications and after-action reports, including those from the public sector, nongovernmental organizations (NGOs), survivors of Ebola, and Ebola-affected households and communities...
October 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27668798/the-ubiquitin-ligase-huwe1-regulates-the-maintenance-and-lymphoid-commitment-of-hematopoietic-stem-cells
#9
Bryan King, Francesco Boccalatte, Kelly Moran-Crusio, Elmar Wolf, Jingjing Wang, Clarisse Kayembe, Charalampos Lazaris, Xiaofeng Yu, Beatriz Aranda-Orgilles, Anna Lasorella, Iannis Aifantis
Hematopoietic stem cells (HSCs) are dormant in the bone marrow and can be activated in response to diverse stresses to replenish all blood cell types. We identified the ubiquitin ligase Huwe1 as a crucial regulator of HSC function via its post-translational control of the oncoprotein N-myc (encoded by Mycn). We found Huwe1 to be essential for HSC self-renewal, quiescence and lymphoid-fate specification in mice. Through the use of a fluorescent fusion allele (Mycn(M)), we observed that N-myc expression was restricted to the most immature, multipotent stem and progenitor populations...
November 2016: Nature Immunology
https://www.readbyqxmd.com/read/27666446/a-depleting-antibody-toward-sca-1-mitigates-a-surge-of-cd34-c-kit-progenitors-and-reduces-vascular-restenosis-in-a-murine-vascular-injury-model
#10
Bryan W Tillman, Jeremy Kelly, Tara D Richards, Alex F Chen, Albert D Donnenberg, Vera S Donnenberg, Edith Tzeng
OBJECTIVE: Vascular restenosis remains a major obstacle to long-term success after vascular intervention. Circulating progenitor cells have been implicated in restenosis, and yet it has remained unclear if these cells, particularly nonendothelial progenitors, have an active role in this pathologic process. We hypothesized that circulating CD34(+)/c-kit(+) progenitors would increase after vascular injury, mirrored by changes in the injury signal, stromal cell-derived factor 1α (sdf1α)...
October 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27616701/assessing-electronic-health-record-phenotypes-against-gold-standard-diagnostic-criteria-for-diabetes-mellitus
#11
Susan E Spratt, Katherine Pereira, Bradi B Granger, Bryan C Batch, Matthew Phelan, Michael Pencina, Marie Lynn Miranda, Ebony Boulware, Joseph E Lucas, Charlotte L Nelson, Benjamin Neely, Benjamin A Goldstein, Pamela Barth, Rachel L Richesson, Isaretta L Riley, Leonor Corsino, Eugenia R McPeek Hinz, Shelley Rusincovitch, Jennifer Green, Anna Beth Barton, Carly Kelley, Kristen Hyland, Monica Tang, Amanda Elliott, Ewa Ruel, Alexander Clark, Melanie Mabrey, Kay Lyn Morrissey, Jyothi Rao, Beatrice Hong, Marjorie Pierre-Louis, Katherine Kelly, Nicole Jelesoff
OBJECTIVE: We assessed the sensitivity and specificity of 8 electronic health record (EHR)-based phenotypes for diabetes mellitus against gold-standard American Diabetes Association (ADA) diagnostic criteria via chart review by clinical experts. MATERIALS AND METHODS: We identified EHR-based diabetes phenotype definitions that were developed for various purposes by a variety of users, including academic medical centers, Medicare, the New York City Health Department, and pharmacy benefit managers...
September 11, 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27565168/the-impact-of-interventions-that-integrate-accelerometers-on-physical-activity-and-weight-loss-a-systematic-review
#12
Adam P Goode, Katherine S Hall, Bryan C Batch, Kim M Huffman, S Nicole Hastings, Kelli D Allen, Ryan J Shaw, Frances A Kanach, Jennifer R McDuffie, Andrzej S Kosinski, John W Williams, Jennifer M Gierisch
BACKGROUND: Regular physical activity is important for improving and maintaining health, but sedentary behavior is difficult to change. Providing objective, real-time feedback on physical activity with wearable motion-sensing technologies (activity monitors) may be a promising, scalable strategy to increase physical activity or decrease weight. PURPOSE: We synthesized the literature on the use of wearable activity monitors for improving physical activity and weight-related outcomes and evaluated moderating factors that may have an impact on effectiveness...
August 26, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27559122/incidence-of-aids-defining-opportunistic-infections-in-a-multicohort-analysis-of-hiv-infected-persons-in-the-united-states-and-canada-2000-2010
#13
Kate Buchacz, Bryan Lau, Yuezhou Jing, Ronald Bosch, Alison G Abraham, M John Gill, Michael J Silverberg, James J Goedert, Timothy R Sterling, Keri N Althoff, Jeffrey N Martin, Greer Burkholder, Neel Gandhi, Hasina Samji, Pragna Patel, Anita Rachlis, Jennifer E Thorne, Sonia Napravnik, Keith Henry, Angel Mayor, Kelly Gebo, Stephen J Gange, Richard D Moore, John T Brooks
BACKGROUND: There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada. METHODS: We studied HIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21%) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed incident OIs among the remaining 63 541 persons, most of whom received antiretroviral therapy during the observation...
September 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27551733/diagnosis-of-intraabdominal-fluid-extravasation-after-hip-arthroscopy-with-point-of-care-ultrasonography-can-identify-patients-at-an-increased-risk-for-postoperative-pain
#14
Stephen C Haskins, Natasha A Desai, Kara G Fields, Jemiel A Nejim, Stephanie Cheng, Struan H Coleman, Danyal H Nawabi, Bryan T Kelly
BACKGROUND: Intraabdominal fluid extravasation (IAFE) after hip arthroscopy has historically been diagnosed in catastrophic circumstances with abdominal compartment syndrome requiring diuresis or surgical decompression. A previous retrospective study found the prevalence of symptomatic IAFE requiring diuresis or decompression to be 0.16%, with risk factors including surgical procedure and high pump pressures. IAFE can be diagnosed rapidly by using point-of-care ultrasound (POCUS) via the Focused Assessment With Sonography for Trauma (FAST) examination, which is a well-established means to detect free fluid with high specificity and sensitivity...
August 22, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27539130/return-to-play-rates-following-arthroscopic-treatment-of-femoroacetabular-impingement-in-competitive-baseball-players
#15
Ryan M Degen, Kara G Fields, C Sally Wentzel, Bethanne Bartscherer, Anil S Ranawat, Struan H Coleman, Bryan T Kelly
OBJECTIVE: Femoroacetabular impingement (FAI) has been increasingly recognized in cutting sports including soccer, hockey and football. More recently, the prevalence among overhead athletes has also been recognized. The purpose of this study was to review impingement patterns, return-to-play rates and clinical outcome following arthroscopic treatment of FAI among high-level baseball players. METHODS: Between 2010 and 2014, 70 competitive baseball players (86 hips; age 22...
November 2016: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/27490671/arthroscopic-treatment-of-cam-type-impingement-of-the-hip
#16
Christopher Kweon, K Linnea Welton, Bryan T Kelly, Christopher M Larson, Asheesh Bedi
No abstract text is available yet for this article.
September 15, 2015: JBJS Reviews
https://www.readbyqxmd.com/read/27490474/arthroscopic-treatment-of-pincer-type-impingement-of-the-hip
#17
Eileen A Crawford, K Linnea Welton, Christopher Kweon, Bryan T Kelly, Christopher M Larson, Asheesh Bedi
No abstract text is available yet for this article.
August 25, 2015: JBJS Reviews
https://www.readbyqxmd.com/read/27416990/patient-characteristics-and-early-functional-outcomes-of-combined-arthroscopic-labral-refixation-and-periacetabular-osteotomy-for-symptomatic-acetabular-dysplasia
#18
Benjamin F Ricciardi, Stephanie W Mayer, Kara G Fields, Catherine Wentzel, Bryan T Kelly, Ernest L Sink
BACKGROUND: Symptomatic labral tears are common in patients with acetabular dysplasia; however, optimal treatment of the labrum remains controversial. PURPOSE: To present patient characteristics and early functional outcomes associated with combined arthroscopic labral refixation and Bernese periacetabular osteotomy (PAO) for symptomatic acetabular dysplasia with a displaced labral tear from the acetabular rim. STUDY DESIGN: Cohort study; Level of evidence, 3...
October 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27399777/canopy-venom-proteomic-comparison-among-new-world-arboreal-pit-viper-venoms
#19
Jordan Debono, Chip Cochran, Sanjaya Kuruppu, Amanda Nouwens, Niwanthi W Rajapakse, Minami Kawasaki, Kelly Wood, James Dobson, Kate Baumann, Mahdokht Jouiaei, Timothy N W Jackson, Ivan Koludarov, Dolyce Low, Syed A Ali, A Ian Smith, Andrew Barnes, Bryan G Fry
Central and South American pitvipers, belonging to the genera Bothrops and Bothriechis, have independently evolved arboreal tendencies. Little is known regarding the composition and activity of their venoms. In order to close this knowledge gap, venom proteomics and toxin activity of species of Bothriechis, and Bothrops (including Bothriopsis) were investigated through established analytical methods. A combination of proteomics and bioactivity techniques was used to demonstrate a similar diversification of venom composition between large and small species within Bothriechis and Bothriopsis...
2016: Toxins
https://www.readbyqxmd.com/read/27367781/genetics-and-genomics-of-longitudinal-lung-function-patterns-in-asthmatics
#20
Michael J McGeachie, Katherine P Yates, Xiaobo Zhou, Feng Guo, Alice L Sternberg, Mark L Van Natta, Robert A Wise, Stanley J Szefler, Sunita Sharma, Alvin T Kho, Michael H Cho, Damien C Croteau-Chonka, Peter J Castaldi, Gaurav Jain, Amartya Sanyal, Ye Zhan, Bryan R Lajoie, Job Dekker, John Stamatoyannopoulos, Ronina A Covar, Robert S Zeiger, N Franklin Adkinson, Paul V Williams, H William Kelly, Hartmut Grasemann, Judith M Vonk, Gerard H Koppelman, Dirkje S Postma, Benjamin A Raby, Isaac Houston, Quan Lu, Anne L Fuhlbrigge, Kelan G Tantisira, Edwin K Silverman, James Tonascia, Robert C Strunk, Scott T Weiss
RATIONALE: Patterns of longitudinal lung function growth and decline in childhood asthma have been shown to be important in determining risk for future respiratory ailments including chronic airway obstruction and chronic obstructive pulmonary disease (COPD). OBJECTIVES: To determine the genetic underpinnings of lung function patterns in childhood asthmatics. METHODS: We performed a genome-wide association study of 581 non-Hispanic white asthmatics that were previously classified by patterns of lung function growth and decline, (Normal Growth, Normal Growth with Early Decline, Reduced Growth, and Reduced Growth with Early Decline)...
July 1, 2016: American Journal of Respiratory and Critical Care Medicine
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