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https://www.readbyqxmd.com/read/28222513/clinical-effectiveness-and-tolerability-of-electroconvulsive-therapy-in-patients-with-neuropsychiatric-symptoms-of-dementia
#1
Moshe Isserles, Zafiris J Daskalakis, Sanjeev Kumar, Tarek K Rajji, Daniel M Blumberger
BACKGROUND: Dementia frequently presents with aggression, agitation, and disorganized behavior for which current treatment is partially effective and is associated with significant adverse effects. OBJECTIVE: The aim of this study was to retrospectively assess the clinical effectiveness and tolerability of electroconvulsive therapy (ECT) in a sample of patients with neuropsychiatric symptoms of dementia (NPS) and to explore factors associated with response and with cognitive adverse effects...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28215116/micro-computed-tomography-and-mechanical-evaluation-of-trabecular-bone-structure-in-osteopenic-and-osteoporotic-fractures
#2
Fırat Ozan, Mahmut Pekedis, Şemmi Koyuncu, Taşkın Altay, Hasan Yıldız, Cemil Kayalı
PURPOSE: Osteopenia and osteoporosis are the two most common musculoskeletal disorders in the elderly population. We determined whether osteopenic and osteoporotic patients with fractures exhibit differences in trabecular morphology and biomechanical properties of bone. METHODS: Fourteen osteopenic patients and 28 osteoporotic patients with hip fractures who underwent hemiarthroplasty for proximal femoral fractures caused by low-energy injury were included. Bone mineral density (BMD) measurements were performed...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28213129/cyclic-compressive-stress-induced-scinderin-regulates-progress-of-developmental-dysplasia-of-the-hip
#3
Cheng-Long Wang, Hui Wang, Fei Xiao, Chuan-Dong Wang, Guo-Li Hu, Jun-Feng Zhu, Chao Shen, Bin Zuo, Yi-Min Cui, De Li, Yuan-Gao, Xiao-Ling Zhang, Xiao-Dong Chen
Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder characterized by a mismatch between acetabulum and femoral head. Mechanical force plays an important role during the occurrence and development of abnormities in acetabulum and femoral head. In this study, we established a mechanical force model named cyclic compressive stress (Ccs). To analyze the effect of Ccs on DDH, we detected special genes in chondrocytes and osteoblasts. Results showed that Ccs downregulated chondrogenesis of ADTC5 in a concentration-dependent manner...
February 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28210985/lumbar-disc-degeneration-was-not-related-to-spine-and-hip-bone-mineral-densities-in-chinese-facet-joint-osteoarthritis-may-confound-the-association
#4
Jianjiang Pan, Xuan Lu, Ge Yang, Yongmei Han, Xiang Tong, Yue Wang
: A sample of 512 Chinese was studied and we observed that greater disc degeneration on MRI was associated with greater spine DXA BMD. Yet, this association may be confounded by facet joint osteoarthritis. BMD may not be a risk factor for lumbar disc degeneration in Chinese. PURPOSE: Evidence suggested that lumbar vertebral bone and intervertebral disc interact with each other in multiple ways. The current paper aims to determine the association between bone mineral density (BMD) and lumbar disc degeneration using a sample of Chinese...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28202082/bone-morphogenetic-proteins-and-myostatin-pathways-key-mediator-of-human-sarcopenia
#5
Manuel Scimeca, Eleonora Piccirilli, Francesca Mastrangeli, Cecilia Rao, Maurizio Feola, Augusto Orlandi, Elena Gasbarra, Elena Bonanno, Umberto Tarantino
BACKGROUND: Sarcopenia, osteoporosis and osteoarthritis are the most frequent musculoskeletal disorders affecting older people. The main aim of this study was to test the hypothesis that the balance between BMPs and myostatin pathways regulates the age-related muscle degeneration in OP and OA patients. To this end, we investigated the relationship among the expression of BMP-2/4-7, myostatin and phosphorylated Smads1-5-8 and the muscle quality, evaluated in term of fibers atrophy and satellite cells activity...
February 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28194488/adult-onset-idiopathic-chondrolysis-of-the-hip
#6
Liam Z Yapp, Liusaidh McClymont, Ian Beggs, Paul Gaston, Donald M Salter
We report the case of a 23-year-old man diagnosed with adult-onset idiopathic chondrolysis of the hip. Chondrolysis of the hip is a disorder most frequently seen in children who have suffered with slipped capital femoral epiphyses. Idiopathic chondrolysis of the hip is extremely rare and to our knowledge, its onset has never been documented in adults aged over 20. With reference to the available medical literature, we summarise the current clinical management of this unusual but important cause of young adult hip pain...
February 13, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28194004/genetic-contributions-to-self-reported-tiredness
#7
V Deary, S P Hagenaars, S E Harris, W D Hill, G Davies, D C M Liewald, A M McIntosh, C R Gale, I J Deary
Self-reported tiredness and low energy, often called fatigue, are associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6 and 50%. In the UK Biobank sample (N=108 976), we carried out a genome-wide association study (GWAS) of responses to the question, 'Over the last two weeks, how often have you felt tired or had little energy?' Univariate GCTA-GREML found that the proportion of variance explained by all common single-nucleotide polymorphisms for this tiredness question was 8...
February 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28186870/total-hip-arthroplasty-via-the-direct-anterior-approach-with-kerboull-type-acetabular-reinforcement-device-for-an-elderly-female-with-factor-xi-deficiency
#8
Kei Sano, Yasuhiro Homma, Tomonori Baba, Jun Ando, Mikio Matsumoto, Hideo Kobayashi, Takahito Yuasa, Kazuo Kaneko
We present a case of successful and uncomplicated total hip arthroplasty with an acetabular reinforcement device in an elderly patient with hip osteoarthritis already diagnosed with factor XI deficiency, which is a very rare bleeding disorder and at high risk of post-operative haemorrhage, and it poses a substantial challenge to surgeons as a consequence of the specific risks of infection and fixation failure. Moreover, bone fragility in elderly patient increases potential risk of adverse event. Fresh frozen plasma was used to supplement factor XI activity...
2017: SICOT-J
https://www.readbyqxmd.com/read/28185391/severe-cartilage-degeneration-in-patients-with-developmental-dysplasia-of-the-hip
#9
Wei-Jia Feng, Hui Wang, Chao Shen, Jun-Feng Zhu, Xiao-Dong Chen
Developmental dysplasia of the hip (DDH) is a developmental disorder that has long-term chronic pain and limited hip joint mobility as major pathological characteristics. This study aims to access the association between the development of DDH and cartilage metabolic disorders. Cartilage tissue samples were acquired from patients with DDH, osteoarthritis (OA) and femoral neck fracture. The proteoglycan level was evaluated by safranin O-fast green, toluidine blue and hematoxylin-eosin (HE) staining. The levels of collagen-II (Col-II), collagen-X (Col-X) and metal matrix proteinase-13 (MMP-13) were evaluated by immunohistochemistry (IHC) and Western blotting analysis...
February 10, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28178164/blood-mean-platelet-volume-and-platelet-lymphocyte-ratio-as-new-predictors-of-hip-osteoarthritis-severity
#10
Özlem Taşoğlu, Ali Şahin, Gülşah Karataş, Engin Koyuncu, İrfan Taşoğlu, Osman Tecimel, Neşe Özgirgin
Osteoarthritis (OA) is a low grade systemic inflammatory disease in which many inflammatory mediators are known to be elevated in the peripheric blood. Blood platelet lymphocyte ratio (PLR) and mean platelet volume (MPV) are accepted as novel markers in many of the systemic inflammatory disorders, but have not been investigated in synovitis-free radiographic OA yet.The aim of this study was to evaluate the levels of blood PLR and MPV in radiographic hip OA. A total of 880 patients were evaluated retrospectively and after certain exclusion criteria, 237 of them who have primary hip OA were included...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28176051/piracetam-attenuates-lps-induced-neuroinflammation-and-cognitive-impairment-in-rats
#11
Alok Tripathi, Pankaj Paliwal, Sairam Krishnamurthy
The present study was performed to investigate the effect of piracetam on neuroinflammation induced by lipopolysaccharide (LPS) and resulting changes in cognitive behavior. Neuroinflammation was induced by a single dose of LPS solution infused into each of the lateral cerebral ventricles in concentrations of 1 μg/μl, at a rate of 1 μl/min over a 5-min period, with a 5-min waiting period between the two infusions. Piracetam in doses of 50, 100, and 200 mg/kg i.p. was administered 30 min before LPS infusion and continued for 9 days...
February 7, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28161747/low-trauma-fractures-without-osteoporosis
#12
REVIEW
E Lespessailles, B Cortet, E Legrand, P Guggenbuhl, C Roux
In clinical practice, areal bone mineral density (aBMD) is usually measured using dual-energy X-ray absorptiometry (DXA) to assess bone status in patients with or without osteoporotic fracture. As BMD has a Gaussian distribution, it is difficult to define a cutoff for osteoporosis diagnosis. Based on epidemiological considerations, WHO defined a DXA-based osteoporosis diagnosis with a T-score <-2.5. However, the majority of individuals who have low-trauma fractures do not have osteoporosis with DXA (i.e...
February 4, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28161230/-slipped-capital-femoral-epiphysis
#13
C Klein, E Haraux, J Leroux, R Gouron
Slipped capital femoral epiphysis (SFCE) is a disorder of the hip, characterized by a displacement of the capital femoral epiphysis from the metaphysic through the femoral growth plate. The epiphysis slips posteriorly and inferiorly. SCFE occurs during puberty and metabolic and epidemiologic risk factors, such as obesity are frequently found. Most chronic slips are diagnosed late. Sagittal hip X-rays show epiphysis slip. In case of untreated SCFE, a slip progression arises with an acute slip risk. Treatment is indicated to prevent slip worsening...
February 1, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28161223/genetic-polymorphisms-in-the-esr1-and-vdr-genes-do-not-correlate-with-osteoporosis-in-patients-with-familial-dysautonomia
#14
David Cheishvili, Channa Maayan, Daniel M Sapozhnikov, Elad Lax, Rivka Dresner-Pollak
One of the major clinical manifestations of familial dysautonomia (FD)-a rare, neurodegenerative, autosomal-recessive disorder-is a high incidence and early onset of osteoporotic bone fractures. Early diagnosis is essential to initiate preventative therapy in at-risk patients and thus improve quality of life. However, the current lack of understanding of the complex relationship between FD and osteoporosis etiology precludes early diagnosis, and as such, accurate predictors of osteoporosis development in FD patients remain to be determined...
February 1, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28160246/hypogonadotropic-hypogonadism-in-males-with-glycogen-storage-disease-type-1
#15
Evelyn M Wong, Anna Lehman, Philip Acott, Jane Gillis, Daniel L Metzger, Sandra Sirrs
BACKGROUND: Glycogen storage disease type 1 is an autosomal recessive disorder with an incidence of 1 in 100,000. Long-term complications include chronic blood glucose lability, lactic academia, short stature, osteoporosis, delayed puberty, gout, progressive renal insufficiency, systemic or pulmonary hypertension, hepatic adenomas at risk for malignant transformation, anemia, vitamin D deficiency, hyperuricemic nephrocalcinosis, inflammatory bowel syndrome (type 1b), hypertriglyceridemia, and irregular menstrual cycles...
February 4, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28160037/effect-of-comorbidities-on-the-association-between-age-and-hospital-mortality-after-fall-related-hip-fracture-in-elderly-patients
#16
A Padrón-Monedero, T López-Cuadrado, I Galán, E V Martínez-Sánchez, P Martin, R Fernández-Cuenca
: The relation between age and mortality after hip fracture was analyzed in elderly patients. 5.5% of the 31,884 patients died. Compared to those 65-74 years old, the multivariate OR for mortality for those 75-84 and ≥85 were 2.11 (95% CI: 1.61-2.77) and 4.10 (95% CI: 3.14-5.35). PURPOSE: To analyze the impact of Elixhauser comorbidities on the relation between age and mortality after hip fracture in elderly patients. METHODS: Cross-sectional study of the population ≥65 years old hospitalized in Spain in 2013 with a diagnosis of fall-related hip fracture in the Basic Minimum Set Data (BMSD)...
February 3, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28157077/altered-hip-mechanics-and-patellofemoral-pain-a-review-of-literature
#17
Gholamhassan Mirzaie, Mehrnaz Kajbafvala, Abbas Rahimi, Farideh Dehghan Manshadi, Khosro Khademi Kalantari
Patellofemoral pain (PFP) is a common knee disorder in orthopedic clinics. In the last decade, several investigations have considered the role of proximal factors in addition to local and distal factors in development of PFP. There is a hypothesis which suggests that impaired neuromuscular control and altered hip joint kinematic affect tibiofemoral and patellofemoral biomechanics. Hence, PFP may develop as a result. This article reviews studies assessing the relationship between altered hip mechanics and PFP...
May 5, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28143500/establishing-percentile-charts-for-hip-joint-capsule-and-synovial-cavity-thickness-in-apparently-healthy-children
#18
Zbigniew Żuber, Aleksander Owczarek, Małgorzata Sobczyk, Agata Migas-Majoch, Dorota Turowska-Heydel, Agnieszka Sternal, Justyna Michalczak, Jerzy Chudek
BACKGROUND: The usefulness of musculoskeletal ultrasonography (MSUS) in paediatric population is limited by lack of reference values. One of such parameters is hip joint capsule thickness, postulated as an early measure for synovitis. However, the joint capsule is hardly a distinguished structure from slit synovial cavity in patients with little or no fluid collection. Therefore, in patients without effusion, it is more convenient to measure hip joint capsule thickness together with synovial cavity...
January 31, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28137249/multiplanar-evaluation-of-radiological-findings-associated-with-acetabular-dysplasia-and-investigation-of-its-prevalence-in-an-asian-population-a-ct-based-study
#19
Tomohiro Mimura, Kanji Mori, Masahiro Kitagawa, Mariko Ueki, Yuki Furuya, Taku Kawasaki, Shinji Imai
BACKGROUND: Acetabular dysplasia (AD) is a well-known cause of osteoarthritis (OA) of the hip, with its prevalence previously determined on plain radiography. The prevalence of preexisting AD was reported as 7.3% in a patient-based Asian population. Although computed tomography (CT) could evaluate AD in multiple planes, its prevalence using multiplanar CT images has not been reported. We investigated its prevalence with CT on coronal, axial, and sagittal planes and then determined if adding the axial and sagittal planes enhanced the investigation...
January 31, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28135674/stress-related-and-basic-determinants-of-hair-cortisol-in-humans-a-meta-analysis
#20
REVIEW
Tobias Stalder, Susann Steudte-Schmiedgen, Nina Alexander, Tim Klucken, Annika Vater, Susann Wichmann, Clemens Kirschbaum, Robert Miller
The analysis of hair cortisol concentrations (HCC) is a relatively new strategy to measure long-term cumulative cortisol levels, which is increasingly used in psychoneuroendocrinological research. Here, we conduct a first comprehensive meta-analysis of HCC research based on aggregated data from a total of 124 (sub)samples (66 independent studies; total N=10,289). We seek to answer two central questions: (i) Which covariates and basic features of HCC need to be considered in future research? (ii) What are the main determinants of HCC in terms of chronic stress exposure and mental health? Concerning basic characteristics, our findings identify several covariates to be considered (age, sex, hair washing frequency, hair treatment, oral contraceptive use), confirm a decline of HCC from the first to the second proximal 3cm hair segment, and show positive associations between HCC and short-term salivary cortisol measures...
January 10, 2017: Psychoneuroendocrinology
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