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https://www.readbyqxmd.com/read/28087489/neurite-density-index-is-sensitive-to-age-related-differences-in-the-developing-brain
#1
Sila Genc, Charles B Malpas, Scott K Holland, Richard Beare, Timothy J Silk
PURPOSE: White matter development during childhood and adolescence is characterised by increasing white matter coherence and organisation. Commonly used scalar metrics, such as fractional anisotropy (FA), are sensitive to multiple mechanisms of white matter change and therefore unable to distinguish between mechanisms that change during development. We investigate the relationship between age and neurite density index (NDI) from neurite orientation dispersion and density imaging (NODDI), and the age-classification accuracy of NDI compared with FA, in a developmental cohort...
January 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28079731/midterm-radiographic-and-functional-outcomes-of-the-anterior-internal-pelvic-fixator-infix
#2
Rahul Vaidya, Adam Jonathan Martin, Matthew Roth, Frederick Tonnos, Bryant Oliphant, Jon Carlson
OBJECTIVE: To describe our experience using the anterior internal pelvic fixator (INIFX) for treating pelvic ring injuries. DESIGN: Case Series SETTING:: Level 1 Trauma Center PATIENTS:: Eighty-three patients with pelvic ring injuries treated with INFIX. Follow up avg. 35 months (range 12-80.33) INTERVENTION:: Surgical treatment of pelvic ring injuries included reduction, appropriate posterior fixation, and INFIX placement. OUTCOME MEASUREMENTS: Reduction using the pelvic deformity index (PDI) and pubic symphysis(PS) widening, Majeed functional scores, complications; infection, implant failure, heterotopic ossification (HO), nerve injury, and pain...
January 5, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28079706/ibuprofen-before-exercise-does-not-prevent-cortical-bone-adaptations-to-training
#3
Vanessa D Sherk, R Dana Carpenter, Erin D Giles, Janine A Higgins, Robera M Oljira, Ginger C Johnson, Samuel Mills, Paul S MacLean
: Using a nonsteroidal anti-inflammatory drug (NSAID) before a single bout of mechanical loading can reduce bone formation response. It is unknown whether this translates to an attenuation of bone strength and structural adaptations to exercise training. PURPOSE: To determine whether NSAID use before exercise prevents increases in bone structure and strength in response to weight-bearing exercise. METHODS: Adult female Wistar rats (n=43) were randomized to Ibuprofen (IBU) or Vehicle (VEH) and Exercise (EX) or Sedentary (SED) groups in a 2x2 (drug, activity) ANCOVA design with body weight as the covariate, and data are reported as mean±SE...
January 10, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28078817/birth-of-puppies-of-predetermined-sex-after-artificial-insemination-with-a-low-number-of-sex-sorted-frozen-thawed-spermatozoa-in-field-conditions
#4
Yun-Fang Wei, Fang-Liang Chen, Shu-Sheng Tang, Ai-Guo Mao, Li-Guang Li, Lu-Guang Cheng, Chao Chen, Fei-Xiang Li, Bin Wang, Tao Xu, Yue-Jun Zhang, Jing Li, Jiu-Sheng Wan
The aim of this study was to evaluate fertility and sex ratios after artificial insemination in dogs under field conditions. Semen was cryopreserved as unsorted (control) or was separated into X- and Y-chromosome-bearing sperm using a cell sorter. Sixty female dogs were inseminated with frozen-thawed spermatozoa of 100 × 10(6) unsorted (a dose in practice) and 4 × 10(6) sorted (X and Y group, respectively). A total of 20 dogs became pregnant and 126 puppies were born from the three groups. The percentage of parturition was similar for the X (5/20; 25...
January 11, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28078795/a-continuous-infusion-dynamic-mri-model-at-3-0-tesla-for-the-serial-quantitative-evaluation-of-microvascular-proliferation-in-an-animal-model-of-glioblastoma-multiforme
#5
Hunter R Underhill
PURPOSE: To develop a continuous-infusion dynamic MRI technique to characterize tumor-associated microvascular proliferation (MVP) in a rat brain model of glioblastoma multiforme. METHODS: The proposed model assumes effects due to tumor-associated MVP (eg, vascular permeability, K(trans) ; intravascular plasma fraction, vp ) cannot be individually separated and solves for a single parameter (k(vasc) ) that quantifies the T1 -weighted contrast enhancement from dynamic images acquired during continuous contrast agent (CA) infusion...
January 12, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28076441/effects-of-an-integrated-fast-track-rehabilitation-service-for-multi-trauma-patients-a-non-randomized-clinical-trial-in-the-netherlands
#6
Ans I E Bouman, Bea Hemmen, Silvia M A A Evers, Henk van de Meent, Ton Ambergen, Pieter E Vos, Peter R G Brink, Henk A M Seelen
OBJECTIVES: The effects on health related outcomes of a newly-developed rehabilitation program, called 'supported Fast Track multi-trauma rehabilitation service' (Fast Track), were evaluated in comparison with conventional trauma rehabilitation service (Care as Usual). METHODS: Prospective, multi-center, non-randomized controlled study. Between 2009 and 2012, 132 adult multi-trauma patients were included: 65 Fast Track and 67 Care as Usual patients with an Injury Severity Score ≥16, complex multiple injuries in several extremities or complex pelvic and/or acetabulum fractures...
2017: PloS One
https://www.readbyqxmd.com/read/28076431/knee-cartilage-thickness-t1%C3%AF-and-t2-relaxation-time-are-related-to-articular-cartilage-loading-in-healthy-adults
#7
Sam Van Rossom, Colin Robert Smith, Lianne Zevenbergen, Darryl Gerard Thelen, Benedicte Vanwanseele, Dieter Van Assche, Ilse Jonkers
Cartilage is responsive to the loading imposed during cyclic routine activities. However, the local relation between cartilage in terms of thickness distribution and biochemical composition and the local contact pressure during walking has not been established. The objective of this study was to evaluate the relation between cartilage thickness, proteoglycan and collagen concentration in the knee joint and knee loading in terms of contact forces and pressure during walking. 3D gait analysis and MRI (3D-FSE, T1ρ relaxation time and T2 relaxation time sequence) of fifteen healthy subjects were acquired...
2017: PloS One
https://www.readbyqxmd.com/read/28074722/-an-adolescent-with-inability-to-bear-weight-on-his-knee-after-a-jump
#8
K E Mager, J G M Frenken, M Guijt
A 15-year-old boy sustained a left tuberositas tibiae avulsion fracture as a result of jumping. This type of fracture typically occurs in adolescent boys during sports.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28074258/the-treatment-options-for-posterior-malleolar-fractures-in-tibial-spiral-fractures
#9
Jialiang Guo, Lei Liu, Zongyou Yang, Zhiyong Hou, Wei Chen, Yingze Zhang
PURPOSE: The posterior malleolar fracture (PMF) in tibial spiral fractures are a common type of complication that occurs in tibial fractures. However, the indication of fixation for posterior fractures is still under debate and varies between different surgeons'. It is not unusual to find the smaller PMF (<25%), which could be treated conservatively within guidelines, treated with internal fixation in clinic. The aim of this study is to evaluate the clinical outcomes of tibial spiral fractures with PMF and provide proper guidance for the treatment of this special fracture...
January 10, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28074234/-biological-downsizing-acetabular-defect-reconstruction-in-revision-total-hip-arthroplasty
#10
S Koob, S Scheidt, T M Randau, M Gathen, M D Wimmer, D C Wirtz, S Gravius
BACKGROUND: Periacetabular bony defects remain a great challenge in revision total hip arthroplasty. After assessment and classification of the defect and selection of a suitable implant the primary stable fixation and sufficient biological reconstitution of a sustainable bone stock are essential for long term success in acetabular revision surgery. Biological defect reconstruction aims for the down-sizing of periacetabular defects for later revision surgeries. TECHNIQUE: In the field of biological augmentation several methods are currently available...
January 10, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28073981/effect-of-resin-ducts-and-sap-content-on-infestation-and-development-of-immature-stages-of-anastrepha-obliqua-and-anastrepha-ludens-diptera-tephritidae-in-four-mango-sapindales-anacardiaceae-cultivars
#11
Larissa Guillén, Ricardo Adaime, Andrea Birke, Olinda Velázquez, Guillermo Angeles, Fernando Ortega, Eliel Ruíz, Martín Aluja
We determined the influence of resin ducts, sap content, and fruit physicochemical features of four mango cultivars (Criollo, Manila, Ataulfo, and Tommy Atkins) on their susceptibility to the attack of the two most pestiferous fruit fly species infesting mangoes in Mexico: Anastrepha ludens (Loew) and Anastrepha obliqua (Macquart). We performed three studies: 1) analysis of resin ducts in mango fruit exocarp to determine the density and area occupied by resin ducts in each mango cultivar, 2) assessment of mango physicochemical features including fruit sap content, and 3) a forced infestation trial under field conditions using enclosed fruit-bearing branches to expose mangoes to gravid A...
January 10, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28072652/in-vivo-correlation-of-radiographic-scoring-rust-and-biomechanical-data-in-a-sheep-osteotomy-model-can-we-define-union-radiographically
#12
Paul Tornetta, Jody Litrenta, William Ricci, Roy Sanders, Robert V O'Toole, Jason W Nascone, Henry Faber, Darren Wilson
OBJECTIVE: To determine 1) the reliability of the standard and modified RUST score in a sheep osteotomy model, and 2) the standard and modified RUST score that represents biomechanical union. DESIGN: The tibia cortices in a sheep osteotomy model treated by intramedullary nails were radiographically evaluated using standard and modified RUST scores. Scores that correlated with biomechanical union, based on the torsional stiffness of the contralateral tibia, were determined...
December 22, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28071011/the-effects-of-a-low-calorie-diet-or-an-isocaloric-diet-combined-with-metformin-on-sex-hormones-in-obese-women-of-child-bearing-age
#13
Ewelina Swora-Cwynar, Magdalena Kujawska-Łuczak, Joanna Suliburska, Julita Reguła, Angelika Kargulewicz, Matylda Kręgielska-Narożna, Emilia Marcinkowska, Alina Kanikowska, Marzena Bielas, Marian Grzymisławski, Paweł Bogdański
BACKGROUND: The influence of weight loss treatment on sex hormones profile has been studied mainly in women with polycystic ovary syndrome (PCOS), but in obese premenopausal women without PCOS it still remains unclear. The aim of the study was to evaluate the effect of two approaches to obesity treatment on the serum level of sex hormones in obese women of child-bearing age without PCOS. METHODS: 77 obese Caucasian women (aged 31.2 ±8.3 years) were randomized into two groups: 39 women received a low-calorie diet (LC) and 38 received an isocaloric diet plus metformin (IM), for 12 weeks...
April 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28070457/the-concurrent-validity-and-reliability-of-the-leg-motion-system-for-measuring-ankle-dorsiflexion-range-of-motion-in-older-adults
#14
Carlos Romero Morales, César Calvo Lobo, David Rodríguez Sanz, Irene Sanz Corbalán, Beatriz Ruiz Ruiz, Daniel López López
BACKGROUND: New reliable devices for range of motion (ROM) measures in older adults are necessary to improve knowledge about the functional capability in this population. Dorsiflexion ROM limitation is associated with ankle injuries, foot pain, lower limb disorders, loss of balance, gait control disorders and fall risk in older adults. The aim of the present study was to assess the validity and reliability of the Leg Motion device for measuring ankle dorsiflexion ROM in older adults. METHODS: Adescriptive repeated-measures study was designed to test the reliability of Leg Motion in thirty-three healthy elderly patients older than 65 years...
2017: PeerJ
https://www.readbyqxmd.com/read/28066519/economic-evaluations-of-interventions-for-transtibial-amputees-a-scoping-review-of-comparative-studies
#15
M Jason Highsmith, Jason T Kahle, Amanda Lewandowski, Tyler D Klenow, John J Orriola, Rebecca M Miro, Owen T Hill, Sylvia Ursula Raschke, Michael S Orendurff, James T Highsmith, Bryce S Sutton
Transtibial amputation (TTA) is life-altering emotionally, functionally, and economically. The economic impact to all stakeholders is largely unknown, as is the cost-effectiveness of prosthetic intervention. This scoping report's purpose was to determine if there is sufficient evidence to conduct a formal systematic review or meta-analysis in any particular prosthetic intervention area and to determine if any evidence statements could be synthesized relative to economic evaluation of interventions provided to patients with TTA...
September 2016: Technology and Innovation
https://www.readbyqxmd.com/read/28063300/a-psma-targeted-theranostic-agent-for-photodynamic-therapy
#16
Ying Chen, Samit Chatterjee, Ala Lisok, Il Minn, Mrudula Pullambhatla, Bryan Wharram, Yuchuan Wang, Jiefu Jin, Zaver M Bhujwalla, Sridhar Nimmagadda, Ronnie C Mease, Martin G Pomper
Prostate-specific membrane antigen (PSMA) is over-expressed in the epithelium of prostate cancer and in the neovasculature of many non-prostate solid tumors. PSMA has been increasingly used as a target for cancer imaging and therapy. Here we describe a low-molecular-weight theranostic photosensitizer, YC-9, for PSMA-targeted optical imaging and photodynamic therapy (PDT). YC-9 was synthesized by conjugating IRDye700DX N-hydroxysuccinimide (NHS) ester with a PSMA targeting Lys-Glu urea through a lysine-suberate linker in suitable yield...
December 18, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28061401/the-effect-of-weight-bearing-asymmetry-on-dynamic-postural-stability-in-people-with-chronic-stroke
#17
Digna de Kam, Jip F Kamphuis, Vivian Weerdesteyn, Alexander C H Geurts
After stroke, weight-bearing asymmetry (WBA) towards the non-paretic side is associated with postural instability. It remains unknown whether WBA is a cause or consequence of postural instability, as both phenomena depend on stroke severity. We investigated the effect of WBA on the ability to recover from balance perturbations in people with stroke. Fourteen people in the chronic phase of stroke underwent multidirectional translational perturbations at three levels of initial WBA (0, 10 and 20% of body weight unloading of the paretic leg)...
December 21, 2016: Gait & Posture
https://www.readbyqxmd.com/read/28058802/increased-thrombin-generation-in-a-mouse-model-of-cancer-cachexia-is-partially-interleukin-6-dependent
#18
Caroline J Reddel, John D Allen, Anahid Ehteda, Ryland Taylor, Vivien M Y Chen, Jennifer L Curnow, Leonard Kritharides, Graham Robertson
BACKGROUND: Cancer cachexia and cancer-associated thrombosis are potentially fatal outcomes of advanced cancer which have not previously been mechanistically linked. The colon 26 (C26) carcinoma is a well-established mouse model of complications of advanced cancer cachexia, partially dependent on high levels of interleukin-6 (IL-6) produced by the tumor. OBJECTIVES: To assess if cancer cachexia altered coagulation state and if this was attributable to tumor IL-6 production...
January 6, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28052005/bortezomib-augments-lymphocyte-stimulatory-cytokine-signaling-in-the-tumor-microenvironment-to-sustain-cd8-t-cell-antitumor-function
#19
Samuel T Pellom, Duafalia F Dudimah, Menaka C Thounaojam, Roman V Uzhachenko, Ashutosh Singhal, Ann Richmond, Anil Shanker
Tumor-induced immune tolerance poses a major challenge for therapeutic interventions aimed to manage cancer. We explored approaches to overcome T-cell suppression in murine breast and kidney adenocarcinomas, and lung fibrosarcoma expressing immunogenic antigens. We observed that treatment with a reversible proteasome inhibitor bortezomib (1 mg/kg body weight) in tumor-bearing mice significantly enhanced the expression of lymphocyte-stimulatory cytokines IL-2, IL-12, and IL-15. Notably, bortezomib administration reduced pulmonary nodules of mammary adenocarcinoma 4T1...
December 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/28051969/effects-of-adding-neuromuscular-electrical-stimulation-to-traditional-military-amputee-rehabilitation
#20
Laura A Talbot, Emily Brede, E Jeffrey Metter
BACKGROUND: Traumatic transtibial amputations lead to an early decline in the use and weight bearing of the residual limb. These changes result in progressive quadriceps muscle atrophy with strength loss that affects standing and walking. Neuromuscular electrical stimulation (NMES) may be useful as an adjunct to amputee prosthetic rehabilitation to maintain quadriceps muscle strength and mass. The objective of this pilot study was to compare the effects of a home-based NMES rehabilitation program plus the traditional military amputee rehabilitation program (TMARP) to the effects of TMARP alone on quadriceps muscle strength, functional mobility, and pain in military service members after a combat-related lower extremity amputation...
January 2017: Military Medicine
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