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https://www.readbyqxmd.com/read/28231701/the-potential-interaction-between-ewe-body-condition-score-and-nutrition-during-very-late-pregnancy-and-lactation-on-the-performance-of-twin-bearing-ewes-and-their-lambs
#1
Lydia Cranston, Paul Kenyon, Rene Corner-Thomas, Steve Morris
Objective: The present study aimed to determine the impact of ewe BCS (over a range of 2.0 to 3.0) and nutritional treatments (consisting of differing herbage masses) during very late pregnancy and lactation and their potential interaction on the performance of twin-bearing ewes and their lambs to weaning. Methods: On day [42 of pregnancy, twin-bearing ewes with a body condition score (BCS) of 2.0, 2.5 or 3.0 were allocated to a "Moderate' or 'Unrestricted' nutritional treatment until day 95 of lactation (weaning)...
February 23, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28231653/implantless-fixation-of-a-large-osteocartilaginous-fracture-of-the-lateral-femoral-condyle-in-a-child
#2
Jitendra Maheshwari, Vikram Mhaskar, Parul Maheshwari Mhaskar
We describe for the first time a case of lateral femoral condyle fracture following a fall in a 13-year-old child that was reduced arthroscopically using a probe. It was definitively fixed with 0 vicryl sutures in a cruciate pattern after being initially stabilised with 1.5-mm Kirschner wires. Four beath pins carrying sutures were drilled at four opposing quadrants through the reduced fragment into the femur. The sutures were then tied on the lateral cortex of the femur. After fixation, the child was kept non-weight bearing for 6 weeks, partial weight bearing from 6 weeks to 12 weeks and then full weight bearing thereafter...
March 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28231498/bone-specific-poly-ethylene-sodium-phosphate-bearing-biodegradable-nanoparticles
#3
Yuya Hirano, Yasuhiko Iwasaki
Chemotherapy is the most reliable treatment for osteoporosis and osseous metastases. To facilitate better drug delivery for bone treatments, a novel preparation of polymeric nanoparticles with high affinity to bone has been prepared. Two-step synthesis of cholesteryl-functionalized poly(ethylene sodium phosphate) (Ch-PEPn·Na) was performed via ring-opening polymerization of cyclic phosphoesters and the demethylation. The molecular weight of Ch-PEPn·Na could be well controlled by changing the ratio of cholesterol and cyclic phosphoesters...
February 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28230661/predicting-progression-in-barrett-s-esophagus-development-and-validation-of-the-barrett-s-esophagus-assessment-of-risk-score-bear-score
#4
Craig S Brown, Brittany Lapin, Jay L Goldstein, John G Linn, Mark S Talamonti, Joann Carbray, Michael B Ujiki
OBJECTIVE: To develop and validate a scoring tool capable of accurately predicting which patients with Barrett's esophagus (BE) will progress to dysplasia and/or esophageal adenocarcinoma. BACKGROUND: Endoscopic therapies have emerged capable of eradicating BE with high efficacy and low complication rates, but which patients should receive treatment is still debated. Current knowledge of risk factors is insufficient to allow for the accurate prediction of which patients will progress to dysplasia or adenocarcinoma...
February 22, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28229355/femoral-shaft-osteotomy-for-obligate-outward-rotation-due-to-scfe
#5
Peter M Stevens, Lucas Anderson, Bruce A MacWilliams
Slipped capital femoral epiphysis (SCFE) is an adolescent disease that leads to retroversion of the femoral neck and shaft, relative to the head. Observing that patients with SCFE must walk with an outward foot progression angle and externally rotate the leg in order to flex the hip, we have been performing a femoral shaft rotational osteotomy wherein we rotate the lower femur 45° inward, relative to the upper femur. By correcting retroversion, our goal is to improve functional hip and knee motion, thereby mitigating the effects of SCFE impingement...
February 22, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28229276/effects-of-chlorella-vulgaris-on-tumor-growth-in-mammary-tumor-bearing-balb-c-mice-discussing-association-of-an-immune-suppressed-protumor-microenvironment-with-serum-ifn%C3%AE-and-igg-decrease-and-spleen-igg-potentiation
#6
Ahad Khalilnezhad, Elham Mahmoudian, Nariman Mosaffa, Ali Anissian, Mohsen Rashidi, Davar Amani
PURPOSE: Chlorella vulgaris (CV) has exhibited immune-enhancing and protective activities against cancer and infections. However, there is an increasing concern about the use of Chlorella species in human, regarding its various molecules with antigenic features found in infectious microorganisms. Our goal was to investigate the impact of higher concentrations of CV on tumor growth in spontaneous mouse mammary tumor (SMMT) models. METHODS: Balb/c mice were daily given CV powder at doses of 0, 200, or 300 mg/kg for 42 days (CONTROL, CV200, and CV300 groups, respectively; n = 6/group)...
February 22, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28229193/osseointegrated-prostheses-for-rehabilitation-following-amputation-the-pioneering-swedish-model
#7
Yan Li, Rickard Brånemark
The direct attachment of osseointegrated (OI) prostheses to the skeleton avoids the inherent problems of socket suspension. It also provides physiological weight bearing, improved range of motion in the proximal joint, as well as osseoperceptive sensory feedback, enabling better control of the artificial limbs by amputees. The present article briefly reviews the pioneering efforts on extremity osseointegration surgeries in Sweden and the development of the OPRA (Osseointegrated Prostheses for the Rehabilitation of Amputees) program...
February 22, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28229166/-morphological-investigations-of-deep-sole-ulcers-in-cattle-part-2-toe-ulcers-white-line-disease-in-the-heel-and-changes-due-to-inappropriate-weight-bearing-and-deficient-claw-care
#8
Susanne Gehringer, Matthias Müller, Johann Maierl
OBJECTIVE: To demonstrate the morphology of pathological changes to the inner structures of the claw in cases of toe ulcers, white line disease in the heel and changes due to inappropriate weight bearing and deficient claw care. MATERIAL AND METHODS: Hind limbs of 55 cows displaying external signs of complicated sole ulcers were examined externally and internally. To examine the samples internally, a sagittal section was performed. Furthermore, the material was examined after bone maceration and histologically...
February 23, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28228787/fix-and-replace-an-emerging-paradigm-for-treating-acetabular-fractures
#9
Colin G Murphy, Andrew D Carrothers
Although technically challenging even for the experienced surgeon, simultaneous open reduction and internal fixation (ORIF) of acetabular fracture and total hip replacement (THR) have some potential advantages over the more traditional treatment options in specific patient subgroups; theoretically allowing immediate weight bearing and faster rehabilitation, reducing the cost of inpatient stay, and reducing the risks of early and late local complications associated with standard treatment for this type of injury...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28227744/classification-of-non-weight-bearing-lower-limb-movements-towards-a-potential-treatment-for-phantom-limb-pain-based-on-myoelectric-pattern-recognition
#10
Eva Lendaro, Max Ortiz-Catalan, Eva Lendaro, Max Ortiz-Catalan, Max Ortiz-Catalan, Eva Lendaro
Research in myoelectric pattern recognition (MPR) for the prediction of motor volition has primarily focused on the upper limbs. Recent studies in the lower limbs have mainly concentrated on prosthetic control, while MPR for lower limb rehabilitation purposes has received little attention. In this work we investigated the viability of a MPR system for the prediction of four degrees of freedom controlled in a near natural or physiologically appropriate fashion. We explored three different electrode configurations for acquiring electromyographic (EMG) signals: two targeted (bipolar and monopolar) and one untargeted (electrodes equally spaced axially)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227317/co-activation-periods-of-gastrocnemius-and-vastus-lateralis-during-walking-evaluated-by-surface-electromyography
#11
Alessandro Mengarelli, Annachiara Strazza, Agnese Sbrollini, Angela Agostinelli, Laura Burattini, Sandro Fioretti, Francesco Di Nardo, Alessandro Mengarelli, Annachiara Strazza, Agnese Sbrollini, Angela Agostinelli, Laura Burattini, Sandro Fioretti, Francesco Di Nardo, Alessandro Mengarelli, Sandro Fioretti, Agnese Sbrollini, Annachiara Strazza, Laura Burattini, Angela Agostinelli, Francesco Di Nardo
"In vivo" studies reported that the co-activation of gastrocnemius and quadriceps femoris (QF) muscles produces ACL strain values greater than those caused by an isolated activation of either muscle. Aim of this study was to assess the co-activation of gastrocnemius (lateral head, GL) and vastus lateralis (VL) in healthy and young adults during walking. To this purpose the Statistical Gait Analysis was performed, that allows a characterization of gait considering hundreds of strides belonging to the same walking trial...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226959/evaluation-of-a-variable-resistance-orthotic-knee-joint
#12
Andrew Herbert-Copley, Edward D Lemaire, Natalie Baddour, Andrew Herbert-Copley, Edward D Lemaire, Natalie Baddour, Andrew Herbert-Copley, Natalie Baddour, Edward D Lemaire
Knee-ankle-foot orthoses (KAFOs) are full leg braces for individuals with knee extensor weakness, designed to support the person during weight bearing activities by preventing knee flexion. KAFOs typically result in an unnatural gait pattern and are primarily used for level ground walking. A novel variable resistance orthotic knee joint, the Ottawalk-Variable Speed (OWVS), was designed to address these limitations. This paper presents a pilot test to evaluate the OWVS functional performance during walking and stair descent...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224272/biomechanical-evaluation-of-reconstruction-plates-with-locking-nonlocking-and-hybrid-screws-configurations-in-calcaneal-fracture-a-finite-element-model-study
#13
Ching-Hsuan Chen, Chinghua Hung, Yu-Chun Hsu, Chen-Sheng Chen, Chao-Ching Chiang
Calcaneal fractures are the most common fractures of the tarsal bones. The stability of fixation is an important factor for successful reconstruction of calcaneal fractures. The purpose of this study was to analyze the biomechanical influence of plate fixation with different combinations of locking and nonlocking screws during early weight-bearing phase. A three-dimensional FE foot model was established using ANSYS software, which comprised bones, cartilages, plantar fascia, and soft tissue. Calcaneal plate was fixed with whole locking (WLS), whole nonlocking (WNS), and hybrid screw configurations for FE analysis...
February 21, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28224178/the-role-of-body-weight-on-bone-in-anorexia-nervosa-a-hr-pqct-study
#14
Jacob Frølich, Stinus Hansen, Laura Al-Dakhiel Winkler, Andreas K Andresen, Anne Pernille Hermann, René K Støving
Anorexia nervosa (AN) is associated with decreased bone mineral density and increased risk of fracture. The aim of this study was to assess bone geometry, volumetric bone mineral density (vBMD), trabecular microarchitecture and estimated failure load in weight-bearing vs. non-weight-bearing bones in AN. We included twenty-five females with AN, and twenty-five female controls matched on age and height. Bone geometry, vBMD and trabecular microarchitecture were assessed using high-resolution peripheral quantitative computed tomography of the distal radius and tibia...
February 21, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28223815/antitumor-effects-of-oncolytic-herpes-simplex-virus-type-2-against-colorectal-cancer-in-vitro-and-in-vivo
#15
Lei Yin, Chunhong Zhao, Jixia Han, Zengjun Li, Yanan Zhen, Ruixue Xiao, Zhongfa Xu, Yanlai Sun
BACKGROUND: The incidence of colorectal cancer (CRC) is on the rise. Furthermore, late-stage diagnoses and limited efficacious treatment options make CRC a complex clinical challenge. Therefore, a new therapeutic regimen with a completely novel therapeutic mechanism is necessary for CRC. In the present study, the therapeutic efficacy of oncolytic herpes simplex virus type 2 (oHSV2) in CRC was assessed in vitro and in vivo. oHSV2 is an oncolytic agent derived from herpes simplex virus type 2 that encodes granulocyte-macrophage colony-stimulating factor...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28223132/ternary-complexes-of-folate-peg-appended-dendrimer-g4-%C3%AE-cyclodextrin-conjugate-sirna-and-low-molecular-weight-polysaccharide-sacran-as-a-novel-tumor-selective-sirna-delivery-system
#16
Ayumu Ohyama, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima
We previously developed a tumor-selective siRNA carrier by preparing polyamidoamine dendrimer (generation 4, G4) conjugates with α-cyclodextrin and folate-polyethylene glycol (Fol-PαC (G4)). In the present study, we developed ternary complexes of Fol-PαC (G4)/siRNA with low-molecular-weight-sacrans to achieve more effective siRNA transfer activity. Among the different molecular-weight sacrans, i.e. sacran 100, 1000 and 10000 (MW 44,889Da, 943,692Da and 1,488,281Da, respectively), sacran 100 significantly increased the cellular uptake and the RNAi effects of Fol-PαC (G4)/siRNA binary complex with negligible cytotoxicity in KB cells (folate receptor-α positive cells)...
February 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28222626/proximal-fibular-osteotomy-a-new-surgery-for-pain-relief-and-improvement-of-joint-function-in-patients-with-knee-osteoarthritis
#17
Xiaohu Wang, Lei Wei, Zhi Lv, Bin Zhao, Zhiqing Duan, Wenjin Wu, Bin Zhang, Xiaochun Wei
Objective To explore the effects of proximal fibular osteotomy as a new surgery for pain relief and improvement of medial joint space and function in patients with knee osteoarthritis. Methods From January 2015 to May 2015, 47 patients who underwent proximal fibular osteotomy for medial compartment osteoarthritis were retrospectively followed up. Preoperative and postoperative weight-bearing and whole lower extremity radiographs were obtained to analyse the alignment of the lower extremity and ratio of the knee joint space (medial/lateral compartment)...
February 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28219850/the-effect-of-aging-on-the-mechanical-behaviour-of-cuticle-in-the-locust-schistocerca-gregaria
#18
Eoin Parle, David Taylor
Despite some previous work on the morphology and mechanical properties of parts of the insect exoskeleton, there is very little known about how these properties change over time during the life of the insect. We examined the hind tibia of the adult desert locust (Schistocerca gregaria) as a function of time up to 63 days following the final moult, a much longer period that previously studied. We identified an initial growth phase, lasting on average 21 days, in which leg thickness increased rapidly (averaging 1...
February 8, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28218852/nickel-catalyzed-copolymerization-of-ethylene-and-alkyl-acrylates
#19
Shixuan Xin, Naomasa Sato, Akio Tannna, Yasuo Oishi, Yohei Konishi, Fumihiko Shimizu
Ni(II) complexes bearing an o-bis(aryl)phosphinophenolate ligand were synthesized as catalysts for copolymerization of ethylene and alkyl acrylates. When the P-bound aryl group was 2,6-dimethoxyphenyl group, one of the oxygen atoms in the methoxy groups coordinated to the nickel center on its apical position as revealed by single crystal X-ray diffraction analysis. This complex was a highly active catalyst without any activators to give highly linear and high molecular weight copolymers. The structures of the copolymers were determined by (1)H and (13)C NMR to clarify that the alkyl acrylate comonomers were incorporated in the main chain and that the structures of the copolymers were significantly influenced by the structure of the aryl group in the ligand...
February 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28218377/current-orthopaedic-management-of-bony-metastases-in-the-proximal-third-of-the-femur
#20
Sam C Jonas, Sanchit M Mehendale, Simon M Bick, Richard P Baker
Patients presenting with skeletal metastatic lesions requiring surgery are increasing, this is due to an ageing population and improved oncological survival following advances in medical management. Furthermore, patients are living longer with skeletal metastatic disease. The majority of bone metastases occur in the proximal femur. Robust diagnosis (Biopsy) and treatment is required to ensure that patients can mobilise fully weight bearing immediately post-surgery and that the construct should outlive the patients expected survival...
February 8, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
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