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https://www.readbyqxmd.com/read/28719567/bunion-surgery-check-these-radiographic-parameters-intraoperatively-to-avoid-recurrence-commentary-on-an-article-by-chul-hyun-park-md-phd-and-woo-chun-lee-md-phd-recurrence-of-hallux-valgus-can-be-predicted-from-immediate-postoperative-non-weight-bearing-radiographs
#1
https://www.readbyqxmd.com/read/28719558/recurrence-of-hallux-valgus-can-be-predicted-from-immediate-postoperative-non-weight-bearing-radiographs
#2
Chul Hyun Park, Woo-Chun Lee
BACKGROUND: The aims of this study were to identify risk factors for the recurrence of hallux valgus deformity and to clarify whether recurrence after surgery to treat hallux valgus can be predicted using radiographic parameters assessed on immediate postoperative non-weight-bearing radiographs. METHODS: A proximal chevron osteotomy combined with a distal soft-tissue procedure was performed by a single surgeon to treat moderate to severe hallux valgus deformity in 93 patients (117 feet)...
July 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28717603/isolated-limb-perfusion-electrochemotherapy-for-the-treatment-of-an-advanced-squamous-cell-carcinoma-of-the-hoof-in-a-mare
#3
Enrico Pierluigi Spugnini, Carlo Bolaffio, Licia Scacco, Alfonso Baldi
A twenty-year-old female saddle horse was referred for evaluation of a seven month, non-healing erosive lesion of the right hind hoof with proliferation and bleeding of the underlying soft tissues. This lesion had been twice surgically treated as a canker but rapidly recurred. Histological examination of the second excision revealed a well-differentiated squamous cell carcinoma. At presentation, the horse was mildly depressed, lame and partially non-weight-bearing on the right hind leg, which exhibited a 10 x 10 cm erosive and proliferative lesion remodeling the hoof...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28714757/comparative-effects-of-four-single-leg-squat-exercises-in-subjects-with-gluteus-medius-weakness
#4
Hae-Rim Han, Chung-Hwi Yi, Sung-Hyun You, Heon-Seock Cynn, One-Bin Lim, Jae-Ik Son
CONTEXT: Of the weight bearing exercises, single leg squat (SLS) represents one of the most commonly used hip strengthening exercises that require more gluteus medius (GMED) activity. To date, no studies have investigated how the four SLS exercises affects muscle imbalance of GMED, tensor fasciae latae (TFL), and adductor longus (AL), and kinematics of hip. OBJECTIVE: To investigate the hip muscle activities, onset time, and kinematics during four different SLS exercises (unilateral squat, unilateral wall-squat, lateral step-down, and front step-down) in subjects with GMED weakness...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28714209/biotransporting-self-assembled-nanofactories-using-polymer-vesicles-with-molecular-permeability-for-enzyme-prodrug-cancer-therapy
#5
Tomoki Nishimura, Yoshihiro Sasaki, Kazunari Akiyoshi
As "biotransporting nanofactories", in vivo therapeutic biocatalyst nanoreactors would enable encapsulated enzymes to transform inert prodrugs or neutralize toxic compounds at target disease sites. This would offer outstanding potential for next-generation therapeutic platforms, such as enzyme prodrug therapy. Designing such advanced materials has, however, proven challenging. Here, it is shown that self-assembled nanofactories formulate with polymeric vesicles with an intrinsically permeable membrane. The vesicles, CAPsomes, are composed of carbohydrate-b-poly(propylene glycol) and show molecular-weight-depended permeability...
July 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28712981/judo-practice-in-early-age-promotes-high-level-of-bone-mass-acquisition-of-growing-boys-skeleton
#6
Kawther Missawi, Mohamed Zouch, Hamada Chaari, Yosra Chakroun, Zouhair Tabka, Elyès Bouajina
The current study aimed to exhibit effects of judo training for at least 2 yr on bone mass parameters in growing boys. Our population was composed of one hundred and thirty boys in tanner stage 1 and aged 10.52 ± 0.86 yr. Eleven judo players were therefore, excluded from the study because they do not have participate regularly to the judo training sessions during the last 2 yr. The resting sample was divided into two groups: 50 judo players (JU group) and 69 controls (C group). Bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were evaluated by using dual-photon X-ray absorptiometry on weight-bearing sites: the whole body, lumbar spine (L2-L4), legs, femoral necks and hips and on the non-weight bearing sites: arms and radiuses...
July 13, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28712488/staged-reconstruction-of-diaphyseal-fractures-with-segmental-defects-surgical-and-patient-reported-outcomes
#7
S D Zoller, L A Cao, R A Smith, W Sheppard, E L Lord, C D Hamad, J H Ghodasra, C Lee, D Jeffcoat
INTRODUCTION: Two-stage limb reconstruction is an option for patients with critical size segmental bone defects following acute trauma or non-union. Reconstruction is technically demanding and associated with a high complication rate. Current protocols for limb reconstruction have well-documented challenges, and no study has reported on patient outcomes using a validated questionnaire. In this study, we aimed to examine the clinical and patient-centered outcomes following our surgical protocol for two-stage limb reconstruction following critical size segmental defects...
June 23, 2017: Injury
https://www.readbyqxmd.com/read/28706171/-hermeneutic-phenomenological-study-on-caring-experience-of-spouses-of-elderly-people-with-dementia-at-home
#8
Hye Young Jang, Myungsun Yi
PURPOSE: This study aimed to understand and describe the caring experiences of spouses of elderly people with dementia. METHODS: The hermeneutic phenomenological method was used and participants were 12 spouses aged 65 and over who were taking care of their husbands or wives with dementia at home. Data were collected from individual in-depth interviews on participants' actual caring experiences. Additionally, novels, movies, and memoirs on elderly couples with partner who had dementia were included as data for the analysis...
June 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28704725/simultaneous-estimation-of-lisofylline-and-pentoxifylline-in-rat-plasma-by-high-performance-liquid-chromatography-photodiode-array-detector-and-its-application-to-pharmacokinetics-in-rat
#9
Kishan S Italiya, Saurabh Sharma, Ishit Kothari, Deepak Chitkara, Anupama Mittal
Lisofylline (LSF) is an anti-inflammatory and immunomodulatory agent with proven activity in serious infections associated with cancer chemotherapy, hyperoxia-induced acute lung injury, autoimmune disorders including type-1 diabetes (T1DM) and islet rejection after islet transplantation. It is also an active metabolite of another anti-inflammatory agent, Pentoxifylline (PTX). LSF bears immense therapeutic potential in multiple pharmacological activities and hence appropriate and accurate quantification of LSF is very important...
June 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28704326/single-marital-status-and-infectious-mortality-in-women-with-cervical-cancer-in-the-united-states
#10
Hiroko Machida, Sarah E Eckhardt, Castaneda Antonio, Erin A Blake, Huyen Q Pham, Lynda D Roman, Koji Matsuo
OBJECTIVE: Unmarried status including single marital status is associated with increased mortality in women bearing malignancy. Infectious disease weights a significant proportion of mortality in patients with malignancy. Here, we examined an association of single marital status and infectious mortality in cervical cancer. METHODS: This is a retrospective observational study examining 86,555 women with invasive cervical cancer identified in the Surveillance, Epidemiology, and End Results Program between 1973 and 2013...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28703910/medialis-pedis-flap-for-reconstruction-of-weight-bearing-heel
#11
Jin Sung Park, Jae Hoon Lee, Jung Suk Lee, Jong Hun Baek
BACKGROUND: Among the various flaps available for the reconstruction of the heel, a medial plantar flap has been widely accepted as the most ideal. This flap, however, involves the medial plantar nerve and its cutaneous branches, which may lead to postoperative hyperesthesia and dual sensation. The purpose of this report was to report the outcomes of the use of the medialis pedis flap for the coverage of weight bearing heel soft tissue defect. PATIENTS AND METHODS: A total of 8 patients who had undergone reconstruction of the weight bearing heel with the medialis pedis flap were enrolled for this study...
July 13, 2017: Microsurgery
https://www.readbyqxmd.com/read/28702785/changes-in-dural-sac-caliber-with-standing-mri-improve-correlation-with-symptoms-of-lumbar-spinal-stenosis
#12
Yvonne Yan On Lau, Ryan Ka Lok Lee, James Francis Griffith, Carol Lai Yee Chan, Sheung Wai Law, Kin On Kwok
PURPOSE: Weight bearing does alter the dimension of lumbar spinal canal, but no study has analyzed its clinical correlation. This study aims to evaluate whether the changes in dural sac cross-sectional area (DSCA) and sagittal anteroposterior (AP) diameter on standing magnetic resonance imaging (MRI) correlate better with clinical symptoms of lumbar spinal stenosis. METHODS: Seventy consecutive patients with neurogenic claudication were prospectively recruited to undergo a 0...
July 12, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28702442/kinematics-and-neuromuscular-recruitment-during-vertical-treadmill-exercise
#13
Alastair R Jordan, Andrew Barnes, David Claxton, Alison Purvis, Mary Fysh
The vertical treadmill (VertiRun) is an unresearched, partial weight-bearing exercise mode for lower limb rehabilitation. The user undertakes a "running-like" action whilst body weight is supported by a bench and the limb is drawn downwards against overhanging resistance cables on a vertically hung nonmotorised treadmill. This study sought to describe the kinematics and neuromuscular recruitment during VertiRun exercise in the supine, 40°, and 70° postures. Twenty-one healthy male participants (age, 25±7 years; stature, 1...
June 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28701540/a-novel-paraplegia-model-in-awake-behaving-macaques
#14
Max Ostrinsky Krucoff, Katie Zhuang, David B Macleod, Allen Yin, Yoon Woo Byun, Roberto Jose Manson, Dennis A Turner, Laura Oliveira, Mikhail A Lebedev
Lower limb paralysis from spinal cord injury (SCI) or neurological disease carries a poor prognosis for recovery and remains a large societal burden. Neurophysiological and neuroprosthetic research have the potential to improve quality of life for these patients; however, the lack of an ethical and sustainable non-human primate model for paraplegia hinders their advancement. Therefore, our multi-disciplinary team developed a way to induce temporary paralysis in awake behaving macaques by creating a fully implantable lumbar epidural catheter-subcutaneous port system that enables easy and reliable targeted drug delivery for sensorimotor blockade...
July 12, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28698880/secure-screw-placement-in-management-of-acetabular-fractures-using-the-suprapectineal-quadrilateral-buttress-plate
#15
R J Egli, M J B Keel, J L Cullmann, J D Bastian
Acetabular fractures involving predominantly the anterior column associated with a disruption of the quadrilateral surface can be treated with instrumentation implementing the stabilization of the quadrilateral surface. The recently introduced suprapectineal quadrilateral buttress plate is specifically designed to prevent secondary medial subluxation of the femoral head, especially in elderly patients with reduced ability for partial weight bearing. Whereas there are guidelines available for safe screw fixation for the anterior and posterior columns, there might be a concern for intra-articular placement of screws placed through the infrapectineal part of the quadrilateral buttress plate...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28697074/repair-of-bimalleolar-ankle-fracture
#16
Nina Fisher, Abiola Atanda, Stephanie Swensen, Kenneth A Egol
PURPOSE: The incidence of ankle fractures is rapidly increasing in geriatric populations. Of the 4 fracture patterns described by the Lauge-Hansen classification system, supination-external rotation (SER) accounts for most ankle fractures. This video demonstrates surgical repair of a SER type 4 ankle fracture in a geriatric patient. METHODS: SER type 4 ankle fractures are considered unstable and are generally treated with surgical fixation. After placement of plate and screws, intraoperative stress tests can be used to assess for syndesmotic widening...
August 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28696002/mitochondrial-dysfunction-is-an-acute-response-of-articular-chondrocytes-to-mechanical-injury
#17
Michelle L Delco, Edward D Bonnevie, Lawrence J Bonassar, Lisa A Fortier
Mitochondrial (MT) dysfunction is known to occur in chondrocytes isolated from end-stage osteoarthritis (OA) patients, but the role of MT dysfunction in the initiation and early pathogenesis of post-traumatic OA (PTOA) remains unclear. The objective of this study was to investigate chondrocyte MT function immediately following mechanical injury in cartilage, and to determine if the response to injury differed between a weight bearing region (medial femoral condyle; MFC) and a non-weight bearing region (distal patellofemoral groove; PFG) of the same joint...
July 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28695498/fmiso-accumulation-in-tumor-is-dependent-on-glutathione-conjugation-capacity-in-addition-to-hypoxic-state
#18
Yukiko Masaki, Yoichi Shimizu, Takeshi Yoshioka, Ken-Ichi Nishijima, Songji Zhao, Kenichi Higashino, Yoshito Numata, Nagara Tamaki, Yuji Kuge
OBJECTIVE: (18)F-fluoromisonidazole (FMISO), a well-known PET imaging probe for diagnosis of hypoxia, is believed to accumulate in hypoxic cells via covalent binding with macromolecules after reduction of the nitro group. Previously, we showed the majority of (18)F-FMISO was incorporated into low-molecular-weight metabolites in hypoxic tumors, and the glutathione conjugate of reduced FMISO (amino-FMISO-GS) distributed in the tumor hypoxic regions as revealed by imaging mass spectrometry (IMS)...
July 10, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28694162/impaired-bone-strength-estimates-at-the-distal-tibia-and-its-determinants-in-adolescents-with-anorexia-nervosa
#19
Vibha Singhal, Shreya S Tulsiani, Karen Joanie Campoverde, Deborah M Mitchell, Meghan Slattery, Melanie Schorr, Karen K Miller, Miriam A Bredella, Madhusmita Misra, Anne Klibanski
BACKGROUND: Altered bone microarchitecture and higher marrow adipose tissue (MAT) may reduce bone strength. High resolution pQCT (HRpQCT) allows assessment of volumetric BMD (vBMD), and size and microarchitecture parameters of bone, while 1H-magnetic resonance spectroscopy (1H-MRS) allows MAT evaluation. We have reported impaired microarchitecture at the non-weight bearing radius in adolescents with anorexia nervosa (AN) and that these changes may precede aBMD deficits. Data are lacking regarding effects of AN on microarchitecture and strength at the weight-bearing tibia in adolescents and young adults, and the impact of changes in microarchitecture and MAT on strength estimates...
July 7, 2017: Bone
https://www.readbyqxmd.com/read/28691695/mechanical-and-biological-characterization-of-alkaline-substituted-orthophosphate-bone-substitutes-containing-meta-and-diphosphates
#20
Moritz Klein, Matthias W Laschke, Joerg H Holstein, Tina Histing, Tim Pohlemann, Michael Menger, Patric Garcia
Despite the growing knowledge on the mechanisms of fracture healing, bone defects often do not heal in a timely manner. Clinically, tricalcium phosphate (Ca-P) bone substitutes are used to fill bone defects and promote bone healing. However, the degradation rate of these implants is often too slow for sufficient bone replacement. The use of calcium phosphate material with the crystalline phase Ca10 [K/Na](PO4)7 containing different amounts of di- and metaphosphates may overcome this problem, because these materials show an accelerated degradation...
July 10, 2017: Biomedical Materials
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