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Brandi Wynne, Trinity Kronk, Otor Al-Khalili, Benjamin Ko, Franziska Theilig, Douglas Eaton, Robert Hoover
OBJECTIVE: Hypertension is characterized by increased sodium reabsorption along the aldosterone-sensitive distal nephron (ASDN) and systemic inflammation. Interleukin-6 (IL-6) is a possible mediator, signaling via the transmembrane IL-6 receptor alpha (IL-6Rα); however, whether IL-6Rα is present in the distal convoluted tubule (DCT) is unknown. Increased sodium reabsorption is not always correlated with increased aldosterone (Aldo). Thus, understanding how Aldo-independent sodium reabsorption occurs is critical...
September 2016: Journal of Hypertension
Rebecca A Weiss, Barry Rosenfeld
As the populations of Western countries become more diverse, the risk of inaccurately generalizing knowledge from majority ethnic groups to minority groups is increasing. However, few of the measures used in forensic assessment are based on normative samples that represent the considerable diversity present in forensic settings. This study examined 4 commonly used measures of feigning: the Dot Counting Test (DCT; Boone, Lu, & Herzberg, 2002); the Miller Forensic Assessment of Symptoms (M-FAST; Miller, 2001); the Test of Memory Malingering (TOMM; Tombaugh, 1996); and a validity scale (atypical responding; ATR) on the Trauma Symptom Inventory-2 (Briere, 2011)...
August 15, 2016: Psychological Assessment
Eedara Prabhakararao, M Sabarimalai Manikandan
In this Letter, the authors propose an efficient and robust method for automatically determining the VT and VF events in the electrocardiogram (ECG) signal. The proposed method consists of: (i) discrete cosine transform (DCT)-based noise suppression; (ii) addition of bipolar sequence of amplitudes with alternating polarity; (iii) zero-crossing rate (ZCR) estimation-based VTVF detection; and (iv) peak-to-peak interval (PPI) feature based VT/VF discrimination. The proposed method is evaluated using 18,000 episodes of different ECG arrhythmias taken from 6 PhysioNet databases...
September 2016: Healthcare Technology Letters
Søren Brandt Poulsen, Birgitte M Christensen
Renal Na+-Cl- cotransporter (NCC) is expressed in early distal convoluted tubule (DCT) 1 and late DCT (DCT2). NCC activity can be stimulated by aldosterone, and the mechanism is assumed to depend on the enzyme, 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which inactivates glucocorticoids that would otherwise occupy aldosterone receptors. Because 11β-HSD2 in rat may only be abundantly expressed in DCT2 cells and not in DCT1 cells, it has been speculated that aldosterone specifically stimulates NCC activity in DCT2 cells...
October 12, 2016: American Journal of Physiology. Renal Physiology
Kristopher J L Irizarry, Randall L Bryden
Color variation provides the opportunity to investigate the genetic basis of evolution and selection. Reptiles are less studied than mammals. Comparative genomics approaches allow for knowledge gained in one species to be leveraged for use in another species. We describe a comparative vertebrate analysis of conserved regulatory modules in pythons aimed at assessing bioinformatics evidence that transcription factors important in mammalian pigmentation phenotypes may also be important in python pigmentation phenotypes...
2016: Advances in Bioinformatics
Luis M San-Jose, Anne-Lyse Ducrest, Valérie Ducret, Céline Simon, Hannes Richter, Kazumasa Wakamatsu, Alexandre Roulin
The melanocortin-1 receptor (MC1R) gene influences coloration by altering the expression of genes acting downstream in the melanin synthesis. MC1R belongs to the melanocortin system, a genetic network coding for the ligands that regulate MC1R and other melanocortin receptors controlling different physiological and behavioural traits. The impact of MC1R variants on these regulatory melanocortin genes was never considered, even though MC1R mutations could alter the influence of these genes on coloration (e.g...
September 24, 2016: Molecular Ecology
Raphael Jumeau, Nicolas Peguret, Berardino de Bari, Raphael Moeckli, Joao-Luis Soares-Rodrigues, Andrea Dante Durham, Sophie Hojnowski, Jean Bourhis, Mahmut Ozsahin, Catherine Beigelman-Aubry
INTRODUCTION: Currently, routine radiotherapy (RT) planning for locally advanced lung cancer (LC) does not take into consideration the functional state of the lung. The goal of this study was to determine if it is technically feasible to integrate the sites of pulmonary emphysema (PE) into the RT planning process. METHODS: Ten patients with LC and PE treated with helical Tomotherapy© were retrospectively included. After extraction by Myrian© software based on diagnostic CT (DCT), the PE data were transferred to the treatment planning system (TPS)...
September 21, 2016: Journal of Medical Imaging and Radiation Oncology
Brandi Wynne, Trinity Kronk, Otor Al-Khalili, Benjamin Ko, Franziska Theilig, Douglas Eaton, Robert Hoover
OBJECTIVE: Hypertension is characterized by increased sodium reabsorption along the aldosterone-sensitive distal nephron (ASDN) and systemic inflammation. Interleukin-6 (IL-6) is a possible mediator, signaling via the transmembrane IL-6 receptor alpha (IL-6Rα); however, whether IL-6Rα is present in the distal convoluted tubule (DCT) is unknown. Increased sodium reabsorption is not always correlated with increased aldosterone (Aldo). Thus, understanding how Aldo-independent sodium reabsorption occurs is critical...
September 2016: Journal of Hypertension
Anukul Pandey, Butta Singh, Barjinder Singh Saini, Neetu Sood
In this paper, a joint use of the discrete cosine transform (DCT), and differential pulse code modulation (DPCM) based quantization is presented for predefined quality controlled electrocardiogram (ECG) data compression. The formulated approach exploits the energy compaction property in transformed domain. The DPCM quantization has been applied to zero-sequence grouped DCT coefficients that were optimally thresholded via Regula-Falsi method. The generated sequence is encoded using Huffman coding. This encoded series is further converted to a valid ASCII code using the standard codebook for transmission purpose...
September 9, 2016: Australasian Physical & Engineering Sciences in Medicine
Xiao Wang, Alexander Yu Sokolov, Justin M Turney, Henry F Schaefer
Density cumulant functional theory (DCT) has recently emerged as an attractive ab initio approach for the treatment of electron correlation. In its orbital-optimized formulation (ODC-12) [J. Chem. Phys. 139, 204110 (2013)], DCT has been shown to provide reliable results for a variety of challenging chemical systems. Among the attractive properties of DCT are its size-consistency and size-extensivity, as well as the efficient computation of the molecular properties and analytic gradients. In this work, we present a new formulation and implementation of DCT that takes advantage of spin adaptation and the density-fitting approximation (DF-ODC-12)...
October 11, 2016: Journal of Chemical Theory and Computation
Alfonso Casado, Carmen Cabarga, Ane Pérez-Sarriegui, Enrique Fuentemilla
PURPOSE: To evaluate the differences in intraocular pressure (IOP) and in corneal biomechanics in eyes with uneventful nonpenetrating deep sclerectomy (NPDS) in 1 eye and with intended deep sclerectomy reconverted into trabeculectomy (RIT) in the fellow eye of the same patient. PARTICIPANTS: Forty eyes of 20 patients with both types of glaucoma surgery and more than 6 months of follow-up, and 31 eyes of 50 controls. METHODS: IOP was assessed with Goldmann applanation tonometry (GAT), ocular response analizer (ORA), and dynamic contour tonometer (DCT)...
September 2, 2016: Journal of Glaucoma
Francesco Trepiccione, Christelle Soukaseum, Anna Iervolino, Federica Petrillo, Miriam Zacchia, Gunther Schütz, Dominique Eladari, Giovambattista Capasso, Juliette Hadchouel
The distal nephron is a heterogeneous part of the nephron composed by six different cell types forming the epithelium of the distal convolute (DCT), connecting (CNT) and collecting duct (CD). To dissect the function of these cells, knock out models specific for their unique cell marker have been created. However, since this part of the nephron develops at the border between the ureteric bud and the metanephric mesenchyme, the specificity of the single cell-markers has been recently questioned. Here, by mapping the fate of the AQP2, NCC-positive cells using transgenic mouse lines expressing the YFP fluorescent marker, we showed that the origin of the distal nephron is extremely composite...
August 31, 2016: American Journal of Physiology. Renal Physiology
Murray A Straus, Kei Saito
Based on information 11,408 university students provided on perpetration of physical assault in a romantic relationship, they were classified into three Dyadic Concordance Types (DCTs). We then examined six risk factors drawn from previous literature of partner violence: physical abuse as a child, antisocial personality characteristics, alcohol abuse, coercive control, chronic denigration in a relationship, and patriarchy at the societal level. We hypothesized that some risk factors for assault are different dependent on the DCT...
August 24, 2016: Journal of Interpersonal Violence
Yan Wang, Guangzhi Chen, Yang Bai, Sheng Li, Andrea Natale, Jianzeng Dong, Hong Wang, Caihua Sang, Ronghui Yu, Deyong Long, Ribo Tang, Xingpeng Liu, Xiaopeng Zhao, Yuanwen Jiang, Changsheng Ma, Dao Wen Wang
The current used parameters for transseptal puncture (TSP) under fluoroscopic guidance is from left atriography and need to be verified by precise anatomic measurement. From February 2009 to July 2013, consecutive patients who received computed tomography (CT) were included. Landmarks and parameters were preliminary studied by right atriography, and further evaluated on the CT images of 1001 patients. A method (CTP-2) was proposed for guiding TSP. In right anterior oblique 45° view, the CTP-2 method was defined by points C, T, and P, and 2 areas: point C is in coronary sinus; point T is at a distance of dCT (usually 1...
August 2016: Medicine (Baltimore)
Jian Sun, Hongru Li, Baohua Xu
Prognostic is a key step of the condition-based maintenance (CBM). In order to improve the predicting performance, a novel method for prognostic for the hydraulic pump is proposed in this paper. Based on the improvement of the traditional composite spectrum, the DCT-composite spectrum (DCS) fusion algorithm is initially presented to make fusion of multi-channel vibration signals. The DCS composite spectrum entropy is extracted as the feature. Furthermore, the modified echo state networks (ESN) model is established for prognostic using the extracted feature...
2016: SpringerPlus
Biswajit Medhi, Gopalakrishna M Hegde, Sai Siva Gorthi, Kalidevapura Jagannath Reddy, Debasish Roy, Ram Mohan Vasu
A simple noninterferometric optical probe is developed to estimate wavefront distortion suffered by a plane wave in its passage through density variations in a hypersonic flow obstructed by a test model in a typical shock tunnel. The probe has a plane light wave trans-illuminating the flow and casting a shadow of a continuous-tone sinusoidal grating. Through a geometrical optics, eikonal approximation to the distorted wavefront, a bilinear approximation to it is related to the location-dependent shift (distortion) suffered by the grating, which can be read out space-continuously from the projected grating image...
August 1, 2016: Applied Optics
David Penton, Jan Czogalla, Agnieszka Wengi, Nina Himmerkus, Dominique Loffing-Cueni, Monique Carrel, Renuga Devi Rajaram, Olivier Staub, Markus Bleich, Frank Schweda, Johannes Loffing
A high dietary potassium (K(+) ) intake causes a rapid dephosphorylation, and hence inactivation, of the thiazide-sensitive NaCl cotransporter (NCC) in the renal distal convoluted tubule (DCT). Based on experiments in heterologous expression systems, it was proposed that changes in extracellular K(+) concentration ([K(+) ]ex ) modulate NCC phosphorylation via a Cl(-) dependent modulation of the WNK-SPAK/OSR1 kinase pathway. We used the isolated perfused mouse kidney technique and ex vivo preparations of mouse kidney slices to test the physiological relevance of this model on native DCT...
July 25, 2016: Journal of Physiology
C G M Scherpenzeel, S H W Tijs, I E M den Uijl, I M G A Santman-Berends, A G J Velthuis, T J G M Lam
The attitude of Dutch dairy farmers toward selective dry cow treatment (SDCT) is unknown, although a favorable mindset toward application of SDCT seems crucial for successful implementation. Given the fact that blanket dry cow treatment has been strongly promoted until recently, the implementation of SDCT was expected to be quite a challenge. This study aimed to provide insight into the level of implementation of SDCT in 2013 in the Netherlands, the methods used by farmers for selection of cows for dry cow treatment (DCT), the relation between SDCT and udder health and antimicrobial usage (AMU) in 2013, and the mindset of farmers toward SDCT...
October 2016: Journal of Dairy Science
Hyun-Jong Cho, Ju-Hwan Park, Dae-Duk Kim, In-Soo Yoon
Docetaxel (DCT) is one of anti-mitotic chemotherapeutic agents and has been used for the treatment of gastric cancer as well as head and neck cancer, breast cancer and prostate cancer. Poly(lactic- co-glycolic) acid (PLGA) is one of representative biocompatible and biodegradable polymers, and polyoxyl 15 hydroxystearate (Solutol HS15) is a nonionic solubilizer and emulsifying agent. In this investigation, PLGA/Solutol HS15-based nanoparticles (NPs) for DCT delivery were fabricated by a modified emulsification-solvent evaporation method...
February 2016: Journal of Nanoscience and Nanotechnology
A Grill, I M Schießl, B Gess, K Fremter, A Hammer, H Castrop
AIM: The basolateral chloride channel ClC-Kb facilitates Cl reabsorption in the distal nephron of the human kidney. Functional mutations in CLCNKB are associated with Bartter's syndrome type 3, a hereditary salt-losing nephropathy. To address the function of ClC-K2 in vivo, we generated ClC-K2-deficient mice. METHODS: ClC-K2-deficient mice were generated using TALEN technology. RESULTS: ClC-K2-deficient mice were viable and born in a Mendelian ratio...
July 16, 2016: Acta Physiologica
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