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https://www.readbyqxmd.com/read/29456684/capn3-dct-mlana-and-tyrp1-are-overexpressed-in-skin-of-vitiligo-vulgaris-mexican-patients
#1
Mauricio Salinas-Santander, Víctor Trevino, Eduardo De la Rosa-Moreno, Bárbara Verduzco-Garza, Celia N Sánchez-Domínguez, Cristina Cantú-Salinas, Jorge Ocampo-Garza, Armando Lagos-Rodríguez, Jorge Ocampo-Candiani, Rocio Ortiz-López
Vitiligo is a disorder causing skin depigmentation, in which several factors have been proposed for its pathogenesis: Environmental, genetic and biological aspects of melanocytes, even those of the surrounding keratinocytes. However, the lack of understanding of the mechanisms has complicated the task of predicting the development and progression. The present study used microarray analysis to characterize the transcriptional profile of skin from Vitiligo Vulgaris (VV) patients and the identified transcripts were validated using targeted high-throughput RNA sequencing in a broader set of patients...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29428893/detailed-solvent-structural-quantum-chemical-study-and-antimicrobial-activity-of-isatin-schiff-base
#2
Dominik R Brkić, Aleksandra R Božić, Aleksandar D Marinković, Miloš K Milčić, Nevena Ž Prlainović, Fathi H Assaleh, Ilija N Cvijetić, Jasmina B Nikolić, Saša Ž Drmanić
The ratios of E/Z isomers of sixteen synthesized 1,3-dihydro-3-(substituted phenylimino)-2H-indol-2-one were studied using experimental and theoretical methodology. Linear solvation energy relationships (LSER) rationalized solvent influence of the solvent-solute interactions on the UV-Vis absorption maxima shifts (νmax) of both geometrical isomers using the Kamlet-Taft equation. Linear free energy relationships (LFER) in the form of single substituent parameter equation (SSP) was used to analyze substituent effect on pKa, NMR chemical shifts and νmax values...
February 2, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29427117/delayed-cerebral-thrombosis-complicating-pneumococcal-meningitis-an-autopsy-study
#3
Joo-Yeon Engelen-Lee, Matthijs C Brouwer, Eleonora Aronica, Diederik van de Beek
BACKGROUND: Delayed cerebral thrombosis (DCT) is a devastating cerebrovascular complication in patients with excellent initial recovery of pneumococcal meningitis. The aetiology is unknown, but direct bacterial invasion, activation of coagulation or post-infectious immunoglobulin deposition has been suggested. METHODS: We studied histopathology of 4 patients with pneumococcal meningitis complicated by DCT. Results were compared with 8 patients who died of pneumococcal meningitis without DCT and 3 non-meningitis control cases...
February 9, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29412701/the-rise-and-fall-of-novel-renal-magnesium-transporters
#4
Olivier J M Schäffers, Joost G J Hoenderop, René J M Bindels, J H F de Baaij
Body Mg2+ balance is finely regulated in the distal convoluted tubule (DCT), where a tight interplay between transcellular reabsorption, mitochondrial exchange and basolateral extrusion takes place. In the last decades, several research groups have aimed to identify the molecular players in these processes. A multitude of proteins have been proposed to function as Mg2+ transporter in eukaryotes based on phylogenetic analysis, differential gene expression and overexpression studies. However, functional evidence for many of these proteins is lacking...
February 7, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29411326/plasma-adrenomedullin-level-in-children-with-obesity-relationship-to-left-ventricular-function
#5
Kotb Abbass Metwalley, Hekma Saad Farghaly, Tahra Sherief
BACKGROUND: Obese children are at increased risk for abnormal cardiac structure and function. Little is known about adrenomedullin (AM), a cytokine produced in various organs and tissues, as a biomarker of cardiac hypertrophy in obese children. This study aimed to assess the plasma AM levels in a cohort of obese children and its relationship to left ventricular (LV) functions. METHODS: The study included 60 obese children and 60 non-obese children matched for age and gender as control group...
February 6, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29404852/efficient-algorithm-for-baseline-wander-and-powerline-noise-removal-from-ecg-signals-based-on-discrete-fourier-series
#6
Mohamed Bahaz, Redha Benzid
Electrocardiogram (ECG) signals are often contaminated with artefacts and noises which can lead to incorrect diagnosis when they are visually inspected by cardiologists. In this paper, the well-known discrete Fourier series (DFS) is re-explored and an efficient DFS-based method is proposed to reduce contribution of both baseline wander (BW) and powerline interference (PLI) noises in ECG records. In the first step, the determination of the exact number of low frequency harmonics contributing in BW is achieved...
February 5, 2018: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29401477/utility-of-goldmann-applanation-tonometry-for-monitoring-intraocular-pressure-in-glaucoma-patients-with-a-history-of-laser-refractory-surgery
#7
Sang Yeop Lee, Hyoung Won Bae, Hee Jung Kwon, Gong Je Seong, Chan Yun Kim
The utility of Goldmann applanation tonometry (GAT) for monitoring intraocular pressure (IOP) in open-angle glaucoma (OAG) patients with a history of laser refractive surgery was investigated by comparing IOP fluctuations measured using GAT and dynamic contour tonometry (DCT) on the same day. In this retrospective study, patients were divided into one of two subgroups according to IOP fluctuation values using GAT: 43 eyes in the low IOP fluctuation group (LIFG [GAT fluctuation ≤1.7 mmHg]); and 55 eyes in the high IOP fluctuation group (HIFG [GAT fluctuation >1...
2018: PloS One
https://www.readbyqxmd.com/read/29395142/effects-of-reduced-intramammary-antimicrobial-use-during-the-dry-period-on-udder-health-in-dutch-dairy-herds
#8
A Vanhoudt, K van Hees-Huijps, A T M van Knegsel, O C Sampimon, J C M Vernooij, M Nielen, T van Werven
Dry cow therapy (DCT) in the Netherlands changed from mainly blanket to selective antimicrobial DCT. This transition was supported by a national guideline, with the individual somatic cell count (SCC) at the last milk recording before dry-off as the main selection criterion for antimicrobial DCT. The aim of this retrospective observational study is to evaluate the SCC dynamics during the dry period at the herd and individual dry period level following the national transition from mainly blanket to selective antimicrobial DCT...
January 30, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29384416/differential-roles-of-wnk4-in-regulation-of-ncc-in-vivo
#9
Yih-Sheng Yang, Jian Xie, Sung-Sen Yang, Shih-Hua Lin, Chou-Long Huang
The Na+-Cl- cotransporter (NCC) in distal convoluted tubule (DCT) plays important roles in renal NaCl reabsorption. Current hypothesis for the mechanism of regulation of NCC focuses on WNK4 and intracellular Cl- concentration ([Cl-]i). WNK kinases bind Cl- and Cl- binding decreases the catalytic activity. It is believed that hypokalemia under low K+ intake decreases [Cl-]i to activate WNK4, which thereby phosphorylates and stimulates NCC through activation of SPAK. However, increased NCC activity and apical NaCl entry would mitigate the fall in [Cl-]i...
January 31, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29371175/integrated-decentralized-training-for-health-professions-education-at-the-university-of-kwazulu-natal-south-africa-protocol-for-the-i-dect-project
#10
Pragashnie Govender, Verusia Chetty, Deshini Naidoo, Ntsikelelo Pefile
BACKGROUND: The Integrated Decentralized Training (i-DecT) project was created to address the current need for health care in South Africa among resource poor climates in rural and periurban settings. The University of KwaZulu-Natal (UKZN) in South Africa has embarked on a program within the School of Health Sciences (SHS) to decentralize the clinical learning platform in order to address this disparity. Framed in a pragmatic stance, this proposal is geared towards informing the roll out of decentralized clinical training (DCT) within the province of KwaZulu-Natal...
January 25, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29370019/can-corneal-biomechanical-properties-explain-difference-in-tonometric-measurement-in-normal-eyes
#11
Ashim Dey, Rathini Lilian David, Rashima Asokan, Ronnie George
SIGNIFICANCE: Corneal biomechanical parameters can affect intraocular pressure (IOP) measurements by different tonometers compared with Goldmann applanation tonometer. This study implies that corneal hysteresis (CH) and corneal resistance factor (CRF) better explain variability in IOP measurements. PURPOSE: The aim of this study was to evaluate the effect of corneal properties on the difference in IOP measured by the Ocular Response Analyzer (ORA), Rebound Tonometer (RBT), Dynamic Contour Tonometer (DCT), and Tono-Pen from the Goldmann applanation tonometer (GAT)...
January 25, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29357414/effects-of-a-high-sodium-low-potassium-diet-on-renal-calcium-magnesium-and-phosphate-handling
#12
Jenny van der Wijst, Omar A Z Tutakhel, Caro Bos, A H Jan Danser, Ewout J Hoorn, Joost G J Hoenderop, René J M Bindels
The distal convoluted tubule (DCT) of the kidney plays an important role in blood pressure regulation by modulating Na+ reabsorption via the Na+-Cl- cotransporter (NCC). A diet containing high salt (NaCl) and low K+ activates NCC, thereby causing Na+ retention and a rise in blood pressure. Since high blood pressure, hypertension, is associated with changes in serum calcium (Ca2+) and magnesium (Mg2+) levels, we hypothesized that dietary Na+ and K+ intake affects Ca2+ and Mg2+ transport in the DCT. Therefore, the present study aimed to investigate the effect of a high Na+/low K+ diet on renal Ca2+ and Mg2+ handling...
January 10, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29322526/how-are-the-charge-transfer-descriptors-affected-by-the-quality-of-the-underpinning-electronic-density
#13
Federica Maschietto, Marco Campetella, Michael J Frisch, Giovanni Scalmani, Carlo Adamo, Ilaria Ciofini
With the aim of investigating qualitatively and quantitatively the impact of using excited state relaxed or unrelaxed density for the estimation of nature and characteristic of electronic excited states, we analyzed the behavior of 52 exchange correlation functionals for the prediction of density-based indexes such as those recently introduced in literature to evaluate the charge transfer distance (DCT ) (Le Bahers et al. J. Chem. Theory Comput. 2011, 7, 2498) in the case of a prototype family of push-pull dyes...
January 10, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29316092/a-cross-sectional-study-of-confidence-in-minor-surgical-skills-amongst-junior-dentists
#14
R M Keat, S A Sheik, M Thomas, R Albuquerque, K Hill
INTRODUCTION: To work in the National Health Service (NHS) as a dentist, the practitioner needs to be on the UK dental "performer's list". To apply for access to this list and work as a General Dental Practitioner (GDP), dentists must be qualified from the European Economic Area (EEA) or, those trained in the UK, must undertake Dental Foundation Training (DFT). Dentists interested in further taught learning or pursuing specialist training must continue working as "Dental Core Trainees" (DCTs)...
January 6, 2018: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/29315232/recognition-of-activities-of-daily-living-based-on-environmental-analyses-using-audio-fingerprinting-techniques-a-systematic-review
#15
REVIEW
Ivan Miguel Pires, Rui Santos, Nuno Pombo, Nuno M Garcia, Francisco Flórez-Revuelta, Susanna Spinsante, Rossitza Goleva, Eftim Zdravevski
An increase in the accuracy of identification of Activities of Daily Living (ADL) is very important for different goals of Enhanced Living Environments and for Ambient Assisted Living (AAL) tasks. This increase may be achieved through identification of the surrounding environment. Although this is usually used to identify the location, ADL recognition can be improved with the identification of the sound in that particular environment. This paper reviews audio fingerprinting techniques that can be used with the acoustic data acquired from mobile devices...
January 9, 2018: Sensors
https://www.readbyqxmd.com/read/29286376/in-vitro-and-in-vivo-detection-of-mitophagy-in-human-cells-c-elegans-and-mice
#16
Evandro F Fang, Konstantinos Palikaras, Nuo Sun, Elayne M Fivenson, Ryan D Spangler, Jesse S Kerr, Stephanie A Cordonnier, Yujun Hou, Eszter Dombi, Henok Kassahun, Nektarios Tavernarakis, Joanna Poulton, Hilde Nilsen, Vilhelm A Bohr
Mitochondria are the powerhouses of cells and produce cellular energy in the form of ATP. Mitochondrial dysfunction contributes to biological aging and a wide variety of disorders including metabolic diseases, premature aging syndromes, and neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Maintenance of mitochondrial health depends on mitochondrial biogenesis and the efficient clearance of dysfunctional mitochondria through mitophagy. Experimental methods to accurately detect autophagy/mitophagy, especially in animal models, have been challenging to develop...
November 22, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29242247/chip-regulates-aquaporin-2-quality-control-and-body-water-homeostasis
#17
Qi Wu, Hanne B Moeller, Donté A Stevens, Rebekah Sanchez-Hodge, Gabrielle Childers, Marleen L A Kortenoeven, Lei Cheng, Lena L Rosenbaek, Carrie Rubel, Cam Patterson, Trairak Pisitkun, Jonathan C Schisler, Robert A Fenton
The importance of the kidney distal convoluted tubule (DCT) and cortical collecting duct (CCD) is highlighted by various water and electrolyte disorders that arise when the unique transport properties of these segments are disturbed. Despite this critical role, little is known about which proteins have a regulatory role in these cells and how these cells can be regulated by individual physiologic stimuli. By combining proteomics, bioinformatics, and cell biology approaches, we found that the E3 ubiquitin ligase CHIP is highly expressed throughout the collecting duct; is modulated in abundance by vasopressin; interacts with aquaporin-2 (AQP2), Hsp70, and Hsc70; and can directly ubiquitylate the water channel AQP2 in vitro shRNA knockdown of CHIP in CCD cells increased AQP2 protein t1/2 and reduced AQP2 ubiquitylation, resulting in greater levels of AQP2 and phosphorylated AQP2...
December 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29240959/evaluation-of-left-ventricular-function-in-overweight-children-and-teenagers-with-arterial-hypertension-and-white-coat-hypertension
#18
Tomasz Florianczyk, Malgorzata Golabek-Dylewska, Beata Kucinska, Bozena Werner
BACKGROUND: Obesity in childhood is strongly associated with elevated arterial blood pressure and risk of hypertension. The aim of the study was the evaluation of left ventricular function in hypertensive and white coat hypertensive overweight children and teenagers. METHODS: The study group consisted of 74 overweight patients aged 10.3 ± 3.1 years (range: 6-16 years) diagnosed as hypertensive in standard blood pressure measurement. The control group consisted of 31 normotensive and normoweight children...
December 14, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29237822/potassium-regulated-distal-tubule-wnk-bodies-are-kidney-specific-wnk1-dependent
#19
Cary R Boyd-Shiwarski, Daniel J Shiwarski, Ankita Roy, Lubika J Nkashama, Hima N Namboodiri, Jian Xie, Kara L McClain, Allison Marciszyn, Thomas R Kleyman, Roderick J Tan, Donna B Stolz, Manojkumar A Puthenveedu, Chou-Long Huang, Arohan R Subramanya
With-No-Lysine (WNK) kinases coordinate volume and potassium homeostasis by regulating renal tubular electrolyte transport. In the distal convoluted tubule (DCT), potassium imbalance causes WNK signaling complexes to concentrate into large discrete foci, which we call "WNK bodies." Though these structures have been reported previously, the mechanisms that drive their assembly remain obscure. Here, we show that kidney-specific WNK1 (KS-WNK1), a truncated kinase-defective WNK1 isoform that is highly expressed in the DCT, is critical for WNK body formation...
December 13, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29232519/using-density-based-indexes-and-wavefunction-methods-for-the-description-of-excited-states-excited-state-proton-transfer-reactions-as-test-case
#20
Juan Sanz García, Federica Maschietto, Marco Campetella, Ilaria Ciofini
To provide tools to interpret photochemical reactions, in this paper we demonstrate how a recently developed density-based index (DCT), up to now used in conjunction with Time Dependent Density Functional Theory methods, can be extended to multi-configurational methods. This index can guide chemists in the interpretation of photochemical reactions providing a measure of the spatial extent of a photo-induced charge transfer and, more generally, of charge transfer phenomena. This qualitative and quantitative description can be particularly relevant in the case of multi-configurational calculations providing a simple tool for the interpretation of their complex outputs...
December 12, 2017: Journal of Physical Chemistry. A
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