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https://www.readbyqxmd.com/read/29050206/wnt-%C3%AE-catenin-signaling-promotes-aging-associated-hair-graying-in-mice
#1
Zhihui Zhang, Mingxing Lei, Haoran Xin, Chunyan Hu, Tian Yang, Yizhan Xing, Yuhong Li, Haiying Guo, Xiaohua Lian, Fang Deng
Canities is an obvious sign of aging in mouse and human, shown as hair graying. Melanocytes in the hair follicle show cyclic activity with hair cycling, which transitions from anagen, catagen to telogen. How the hairs turn gray during aging is not completely uncovered. Here, by using immunostaining and LacZ staining in Dct-LacZ mice, we show that β-catenin is expressed in melanocytes during hair cycling. RT-PCR, western blot and immunostaining show that β-catenin expression is significantly increased in both anagen and telogen skin of aged mice, when compared to the anagen and telogen skin of young mice, respectively...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29046297/renal-and-colonic-potassium-transporters-in-the-pregnant-rat
#2
Crystal A West, Paul A Welling, David A West, Richard A Coleman, Kit-Yan Cheng, Chao Chen, Thomas D DuBose, Jill W Verlander, Chris Baylis, Michelle L Gumz
Gestational potassium retention, most of which occurs during late pregnancy, is essential for fetal development. The purpose of this study was to examine mechanisms underlying changes in potassium handling by the kidney and colon in pregnancy. We found that potassium intake and renal excretion increased in late pregnancy while fecal potassium excretion remained unchanged and that pregnant rats exhibited net potassium retention. By qPCR we found markedly increased H+/K+-ATPase type2 (HKA2) mRNA expression in cortex and OM of late pregnant vs virgin...
October 18, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29032414/influence-of-lasek-on-schi%C3%A3-tz-goldmann-and-dynamic-contour-tonometry
#3
Marco Sales-Sanz, Esther Arranz-Marquez, Carolina Arruabarrena, Miguel A Teus
PURPOSE: Our purpose was to assess the effect of LASEK surgery on ocular rigidity and to compare its effect on intraocular pressure (IOP) readings with Goldmann applanation tonometry (GAT), Schiøtz indentation tonometry (ST) and dynamic contour tonometry (DCT). METHODS: Prospective, observational, single-masked cohort study. One eye per patient from 31 consecutive subjects who underwent LASEK refractive surgery to correct myopia, as well as from 108 non-operated myopic patients, were included...
October 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28992233/boundary-artifact-free-determination-of-potential-distribution-from-differential-phase-contrast-signals
#4
Akimitsu Ishizuka, Masaaki Oka, Takehito Seki, Naoya Shibata, Kazuo Ishizuka
The differential phase contrast (DPC) imaging in STEM was mainly used for a study of magnetic material in a medium resolution. An ideal DPC signals give the center of mass of the diffraction pattern, which is proportional to an electric field. Recently, the possibility of the DPC imaging at atomic resolution was demonstrated. Thus, the DPC imaging opens up the possibility to observe the object phase that is proportional to the electrostatic potential.In this report we investigate the numerical procedures to obtain the object phase from the two perpendicular DPC signals...
August 31, 2017: Microscopy
https://www.readbyqxmd.com/read/28991514/dacryocystectomy-indications-and-results-at-tertiary-eye-hospital-in-central-saudi-arabia
#5
Alicia Galindo-Ferreiro, Mohammed Dufaileej, Alberto Galvez-Ruiz, Rajiv Khandekar, Silvana A Schellini
PURPOSE: To report indications and success rates of dacryocystectomy (DCT) in a tertiary hospital. METHODS: A retrospective chart review was performed of all patients who underwent DCT at the King Khaled Eye Specialist Hospital, Saudi Arabia, from 2008 to 2015. Data included patient demographics, symptoms before and after surgery, and complications. Univariate analysis using parametric and non-parametric methods was performed. RESULTS: Forty-seven DCT surgeries were performed over the study period...
October 9, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28964843/multi-echo-reconstruction-from-partial-k-space-scans-via-adaptively-learnt-basis
#6
Jyoti Maggu, Prerna Singh, Angshul Majumdar
In multi-echo imaging, multiple T1/T2 weighted images of the same cross section is acquired. Acquiring multiple scans is time consuming. In order to accelerate, compressed sensing based techniques have been proposed. In recent times, it has been observed in several areas of traditional compressed sensing, that instead of using fixed basis (wavelet, DCT etc.), considerably better results can be achieved by learning the basis adaptively from the data. Motivated by these studies, we propose to employ such adaptive learning techniques to improve reconstruction of multi-echo scans...
September 28, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28963476/comparative-transcriptome-analysis-of-mink-neovison-vison-skin-reveals-the-key-genes-involved-in-the-melanogenesis-of-black-and-white-coat-colour
#7
Xingchao Song, Chao Xu, Zongyue Liu, Zhigang Yue, Linling Liu, Tongao Yang, Bo Cong, Fuhe Yang
Farmed mink (Neovison vison) is one of the most important fur-bearing species worldwide, and coat colour is a crucial qualitative characteristic that contributes to the economic value of the fur. To identify additional genes that may play important roles in coat colour regulation, Illumina/Solexa high-throughput sequencing technology was used to catalogue the global gene expression profiles in mink skin with two different coat colours (black and white). RNA-seq analysis indicated that a total of 12,557 genes were differentially expressed in black versus white minks, with 3,530 genes up-regulated and 9,027 genes down-regulated in black minks...
September 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28961273/improved-detection-of-dna-binding-proteins-via-compression-technology-on-pssm-information
#8
Yubo Wang, Yijie Ding, Fei Guo, Leyi Wei, Jijun Tang
Since the importance of DNA-binding proteins in multiple biomolecular functions has been recognized, an increasing number of researchers are attempting to identify DNA-binding proteins. In recent years, the machine learning methods have become more and more compelling in the case of protein sequence data soaring, because of their favorable speed and accuracy. In this paper, we extract three features from the protein sequence, namely NMBAC (Normalized Moreau-Broto Autocorrelation), PSSM-DWT (Position-specific scoring matrix-Discrete Wavelet Transform), and PSSM-DCT (Position-specific scoring matrix-Discrete Cosine Transform)...
2017: PloS One
https://www.readbyqxmd.com/read/28956856/towards-a-continuous-biometric-system-based-on-ecg-signals-acquired-on-the-steering-wheel
#9
João Ribeiro Pinto, Jaime S Cardoso, André Lourenço, Carlos Carreiras
Electrocardiogram signals acquired through a steering wheel could be the key to seamless, highly comfortable, and continuous human recognition in driving settings. This paper focuses on the enhancement of the unprecedented lesser quality of such signals, through the combination of Savitzky-Golay and moving average filters, followed by outlier detection and removal based on normalised cross-correlation and clustering, which was able to render ensemble heartbeats of significantly higher quality. Discrete Cosine Transform (DCT) and Haar transform features were extracted and fed to decision methods based on Support Vector Machines (SVM), k-Nearest Neighbours (kNN), Multilayer Perceptrons (MLP), and Gaussian Mixture Models - Universal Background Models (GMM-UBM) classifiers, for both identification and authentication tasks...
September 28, 2017: Sensors
https://www.readbyqxmd.com/read/28956854/an-acoustic-signal-enhancement-method-based-on-independent-vector-analysis-for-moving-target-classification-in-the-wild
#10
Qin Zhao, Feng Guo, Xingshui Zu, Yuchao Chang, Baoqing Li, Xiaobing Yuan
In this paper, we study how to improve the performance of moving target classification by using an acoustic signal enhancement method based on independent vector analysis (IVA) in the unattended ground sensor (UGS) system. Inspired by the IVA algorithm, we propose an improved IVA method based on a microphone array for acoustic signal enhancement in the wild, which adopts a particular multivariate generalized Gaussian distribution as the source prior, an adaptive variable step strategy for the learning algorithm and discrete cosine transform (DCT) to convert the time domain observed signals to the frequency domain...
September 28, 2017: Sensors
https://www.readbyqxmd.com/read/28916561/succinate-transport-is-not-essential-for-symbiotic-nitrogen-fixation-by-sinorhizobium-meliloti-nor-rhizobium-leguminosarum
#11
Michael J Mitsch, George C diCenzo, Alison Cowie, Turlough M Finan
Symbiotic nitrogen fixation (SNF) is an energetically expensive process performed by bacteria during endosymbiotic relationships with plants. The bacteria require the plant to provide a carbon source for generation of reductant to power SNF. While C4-dicarboxylates (succinate, fumarate, malate) appear to be the primary, if not sole, carbon source provided to the bacteria, the contribution of each C4-dicarboxylate is not known. We address this issue using a genetic and systems-level analyses. Expression of a malate specific transporter (MaeP) in Sinorhizobium meliloti Rm1021 dct mutants unable to transport C4-dicarboxylates resulted in malate import rates up to 30% that of wild type...
September 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28901828/protein-kinase-c-enhances-plasma-membrane-expression-of-cardiac-l-type-calcium-channel-cav1-2
#12
Tal Keren Raifman, Prabodh Kumar, Hannelore Haase, Enno Klussmann, Nathan Dascal, Sharon Weiss
L-type-voltage-dependent Ca(2+) channels (L-VDCCs; CaV1.2, α1C), crucial in cardiovascular physiology and pathology, are modulated via activation of G-protein-coupled receptors and subsequently protein kinase C (PKC). Despite extensive study, key aspects of the mechanisms leading to PKC-induced Ca(2+) current increase are unresolved. A notable residue, Ser1928, located in the distal C-terminus (dCT) of α1C was shown to be phosphorylated by PKC. CaV1.2 undergoes posttranslational modifications yielding full-length and proteolytically cleaved CT-truncated forms...
September 13, 2017: Channels
https://www.readbyqxmd.com/read/28895739/metrics-for-molecular-electronic-excitations-a-comparison-between-orbital-and-density-based-descriptors
#13
Marika Savarese, Ciro Achille Guido, Eric Brémond, Ilaria Ciofini, Carlo Adamo
This study proposes a quantitative and qualitative comparison of two popular metrics used for time-dependent density functional simulations of chromophores when describing absorption and emission processes, with high discrimination power between short- and long-range character of involved electronic excitations and functional performances. To this end, a total of 160 absorption and emission electronic excitations of 80 molecular systems belonging to the "Real-Life Molecules" data set, recently introduced in literature, have been considered a relevant data set...
September 27, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28894548/a-novel-algorithm-for-pet-and-mri-fusion-based-on-digital-curvelet-transform-via-extracting-lesions-on-both-images
#14
Shirin Hajeb Mohammad Alipour, Mohammad Houshyari, Ahmad Mostaar
BACKGROUND AND AIM: Merging multimodal images is a useful tool for accurate and efficient diagnosis and analysis in medical applications. The acquired data are a high-quality fused image that contains more information than an individual image. In this paper, we focus on the fusion of MRI gray scale images and PET color images. METHODS: For the fusion of MRI gray scale images and PET color images, we used lesion region extracting based on the digital Curvelet transform (DCT) method...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28892092/high-concordance-of-a-closed-system-rt-qpcr-breast-cancer-assay-for-her2-mrna-compared-to-clinically-determined-immunohistochemistry-fluorescence-in-situ-hybridization-and-quantitative-immunofluorescence
#15
Brad E Wasserman, Daniel E Carvajal-Hausdorf, Kenneth Ho, Wendy Wong, Natalie Wu, Victor C Chu, Edwin W Lai, Jodi M Weidler, Michael Bates, Veronique Neumeister, David L Rimm
Historically, mRNA measurements have been tested on several commercially available platforms, but none have gained broad acceptance for assessment of HER2. An mRNA measurement, as a continuous value, has the potential for use in adjudication of the equivocal category. Here we use a real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay in a closed, single-use cartridge, automated system. Multiple cores (1 mm in diameter) were retrospectively collected from 80 formalin-fixed paraffin-embedded (FFPE) tissue blocks with invasive breast cancer seen by Yale Pathology Labs between 1998 and 2011...
September 11, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28891677/genetic-variation-in-the-mitf-promoter-affects-skin-colour-and-transcriptional-activity-in-black-boned-chickens
#16
G Wang, J Liao, M Tang, S Yu
1. Microphthalmia-associated transcription factor (MITF) plays a pivotal role in melanocyte development by regulating the transcription of major pigmentation enzymes (e.g. TYR, TYRP1 and DCT). A single-nucleotide polymorphism (SNP), c.-638T>C, was identified in the MITF promoter, and genotyping of a population (n = 426) revealed that SNP c.-638T>C was associated with skin colour in black-boned chickens. 2. Individuals with genotypes CC and TC exhibited greater MTIF expression than those with genotype TT...
October 17, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28882112/identification-of-adenylyl-cyclase-isoforms-mediating-parathyroid-hormone-and-calcitonin-stimulated-cyclic-amp-accumulation-in-distal-tubule-cells
#17
Wararat Kittikulsuth, Peter A Friedman, Alfred van Hoek, Yang Gao, Donald E Kohan
BACKGROUND: The distal convoluted tubule (DCT) is an important nephron site for parathyroid hormone (PTH) and calcitonin regulation of urinary divalent cation excretion. These hormones exert their effects on the DCT in substantial part through activation of adenylyl cyclase (AC); however, it is unknown which AC isoforms are involved. METHODS: To examine this, two mouse DCT cell lines were studied: 209 and D1 cells. AC isoform mRNA expression was analyzed by real-time PCR...
September 7, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28880216/inhibition-of-nat10-suppresses-melanogenesis-and-melanoma-growth-by-attenuating-microphthalmia-associated-transcription-factor-mitf-expression
#18
Taek-In Oh, Yoon-Mi Lee, Beong-Ou Lim, Ji-Hong Lim
N-acetyltransferase 10 (NAT10) has been considered a target for the treatment of human diseases such as cancer and laminopathies; however, its functional role in the biology of melanocytes is questionable. Using a small molecule or small interfering RNA targeting NAT10, we examined the effect of NAT10 inhibition on melanogenesis and melanoma growth in human and mouse melanoma cells. Genetic silencing or chemical inhibition of NAT10 resulted in diminished melanin synthesis through the suppression of melanogenesis-stimulating genes such as those encoding dopachrome tautomerase (DCT) and tyrosinase in B16F10 melanoma cells...
September 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28869935/fetal-aneuploidy-a-comparison-of-dichorionic-twins-and-monochorionic-twins
#19
Xiaomei Shi, Lin Li, Xuan Huang, Baojiang Chen, Yi Zhou, Qun Fang
OBJECTIVE: To assess the clinical characteristics of fetal aneuploidy between dichorionic twins (DCT) and monochorionic twins (MCT) undergoing invasive prenatal diagnosis. METHODS: Twin fetuses undergoing invasive prenatal diagnosis were enrolled in this study. All twin fetuses were classified into 2 groups according to chorionicity. The rates of fetal aneuploidy in different groups were compared. RESULT: This study included 1,714 fetuses (857 sets of twin pairs); among them, 1,190 were DCT and 524 were MCT...
September 5, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28858044/tonometry-after-intrastromal-corneal-ring-segments-for-keratoconus
#20
RANDOMIZED CONTROLLED TRIAL
Paula Arribas-Pardo, Carmen Mendez-Hernandez, Ricardo Cuiña-Sardiña, José Manuel Benitez-Del-Castillo, Julian Garcia-Feijoo
SIGNIFICANCE: Reliable intraocular pressure (IOP) measurement after intrastromal corneal ring segments (ICRS) implantation is a challenge because of altered corneal morphology. In this study, IOP is measured with four tonometers, compared with Goldmann applanation tonometry (GAT) values and the influence of corneal parameters is established. PURPOSE: This study compares IOP measurements made using different tonometers in patients implanted with ICRS and assesses the effects of central corneal thickness (CCT), corneal curvature, and corneal astigmatism on the IOP measurements obtained...
October 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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