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https://www.readbyqxmd.com/read/28509314/influence-of-oxygen-concentration-on-t-cell-proliferation-and-susceptibility-to-apoptosis-in-healthy-men-and-women
#1
Agnieszka Waskowska, Katarzyna A Lisowska, Agnieszka Daca, Izabella Henc, Fredrik Brandberg, Paula Mazurek, Edyta Brzustewicz, Jacek M Witkowski, Ewa Bryl
INTRODUCTION: Much of what we know about the functioning of human T lymphocytes is based on the experiments carried out in atmospheric oxygen (O₂) concentrations, which are significantly higher than those maintained in blood. Interestingly, the gender differences in the activity of T cells and their susceptibility to apoptosis under different O₂ conditions have not yet been described. The aim of the study was to compare two main markers of lymphocyte function: proliferation capacity and ability to produce cytokines as well as their susceptibility to apoptosis under two different O₂ concentrations, between men and women...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28496220/using-a-situational-judgement-test-for-selection-into-dental-core-training-a-preliminary-analysis
#2
E Rowett, F Patterson, F Cousans, K Elley
Objective and setting This paper describes the evaluation of a pilot situational judgement test (SJT) for selection into UK Dental Core Training (DCT). The SJT's psychometric properties, group differences based on gender and ethnicity, and candidate reactions were assessed.Methods The SJT targets four non-academic attributes important for success in DCT. Data were collected alongside live selection processes from five Health Education England local teams in the UK (N = 386). Candidates completed the pilot SJT and an evaluation questionnaire to examine their reactions to the test...
May 12, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28494071/correlation-between-dynamic-contour-tonometry-uncorrected-and-corrected-goldmann-applanation-tonometry-and-stage-of-glaucoma
#3
Josephine Wachtl, Marc Töteberg-Harms, Sonja Frimmel, Malgorzata Roos, Christoph Kniestedt
Importance: Accurate determination of intraocular pressure (IOP) is crucial for the diagnosis and management of glaucoma. Objective clinical evaluation of the correction equations for Goldmann applanation tonometry (GAT) is lacking. Objectives: To investigate the difference between corrected and conventional GAT and Pascal dynamic contour tonometry (DCT) measurements, as well as the correlation between discordant IOP values and stage of glaucoma. Design, Setting, and Participants: This prospective cross-sectional case series was conducted at the Department of Ophthalmology, University Hospital Zurich, and Talacker Eye Center between July 1, 2011, and May 31, 2016, among 112 white patients with glaucoma...
May 11, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28489372/psi4-1-1-an-open-source-electronic-structure-program-emphasizing-automation-advanced-libraries-and-interoperability
#4
Robert M Parrish, Lori A Burns, Daniel G A Smith, Andrew C Simmonett, A Eugene DePrince, Edward G Hohenstein, Ugur Bozkaya, Alexander Yu Sokolov, Roberto Di Remigio, Ryan Matthew Richard, Jérôme F Gonthier, Andrew M James, Harley R McAlexander, Ashutosh Kumar, Masaaki Saitow, Xiao Wang, Benjamin P Pritchard, Prakash Verma, Henry F Schaefer, Konrad Patkowski, Rollin A King, Edward F Valeev, Francesco A Evangelista, Justin M Turney, T Daniel Crawford, C David Sherrill
Psi4 is an ab initio electronic structure program providing methods such as Hartree-Fock, density functional theory, configuration interaction, and coupled-cluster theory. The 1.1 release represents a major update meant to automate complex tasks, such as geometry optimization using complete-basis-set extrapolation or focal-point methods. Conversion of the top-level code to a Python module means that Psi4 can now be used in complex workflows alongside other Python tools. Several new features have been added with the aid of libraries providing easy access to techniques such as density fitting, Cholesky decomposition, and Laplace denominators...
May 10, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28483640/characterization-of-constitutive-and-acid-induced-outwardly-rectifying-chloride-currents-in-immortalized-mouse-distal-tubular-cells
#5
William C Valinsky, Rhian M Touyz, Alvin Shrier
Thiazides block Na(+) reabsorption while enhancing Ca(2+) reabsorption in the kidney. As previously demonstrated in immortalized mouse DCT (MDCT) cells, chlorothiazide application induced a robust plasma membrane hyperpolarization, which increased Ca(2+) uptake. This essential thiazide-induced hyperpolarization was prevented by the Cl(-) channel inhibitor 5-Nitro-2-(3-phenylpropylamino) benzoic acid (NPPB), implicating NPPB-sensitive Cl(-) channels, however the nature of these Cl(-) channels has been rarely described in the literature...
May 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28481450/novel-regulation-of-melanogenesis-by-adiponectin-via-the-ampk-crtc-pathway
#6
Seunghyun Bang, Kwang Hee Won, Hye-Rim Moon, Hanju Yoo, Areum Hong, Youngsup Song, Sung Eun Chang
Several studies observed that adiponectin, an important adipokine that improves glucose metabolism by regulating AMP-activated protein kinase (AMPK) signaling, is dermatologically beneficial. In our recent microarray data, we found that adiponectin expression was lower in lesional skin than in non-lesional skin of melasma patients. Given that AMPK is a key adiponectin signaling mediator, we investigated the role of adiponectin and AICAR, a cell-permeable AMPK activator, in melanogenesis. We herein showed that adiponectin and AICAR downregulated MITF, tyrosinase, TRP-1, and DCT expression and reduced melanin content in normal human and mouse melanocytes...
May 8, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28471235/mechanism-of-grape-seeds-extract-protection-against-paracetamol-renal-cortical-damage-in-male-albino-rats
#7
S M N Abdel-Hafez, R A Rifaai, W Y Abd Elzaher
OBJECTIVE: The aim of the study was to assess the possible protective role of grape seeds extract (GSE) in ameliorating the toxic effects of paracetamol overdose on the rat renal cortical tissue. BACKGROUND: Paracetamol is one of the widely used non-steroidal anti-inflammatory drugs (NSAIDs). Unfortunately, it was reported as the most common cause of toxic ingestion in the world. Grape seeds extract (GSE) is known to have a strong antioxidant and anti-inflammatory properties...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28452601/updating-the-rey-dot-counting-test-for-use-in-collegiate-baseline-concussion-testing
#8
Carlos Luis Salazar, Kevin Mulligan, Frank Webbe
Athletes occasionally attempt to lower their baseline scores to mask the effects of a concussion during post-trauma assessment, a phenomenon known as sandbagging. In order to help prevent this from occurring, the Rey Dot Counting Test (DCT) was examined as a potential measure to be added to a Division II university screening battery. Investigators utilized samples of athletes at baseline and non-athlete students instructed to provide honest effort or suppressed effort, either naïvely or coached. The results support the use of the DCT as a valid measure of suboptimal performance when using modified norms established from collegiate populations...
2017: Developmental Neuropsychology
https://www.readbyqxmd.com/read/28442491/constitutively-active-spak-causes-hyperkalemia-by-activating-ncc-and-remodeling-distal-tubules
#9
P Richard Grimm, Richard Coleman, Eric Delpire, Paul A Welling
Aberrant activation of with no lysine (WNK) kinases causes familial hyperkalemic hypertension (FHHt). Thiazide diuretics treat the disease, fostering the view that hyperactivation of the thiazide-sensitive sodium-chloride cotransporter (NCC) in the distal convoluted tubule (DCT) is solely responsible. However, aberrant signaling in the aldosterone-sensitive distal nephron (ASDN) and inhibition of the potassium-excretory renal outer medullary potassium (ROMK) channel have also been implicated. To test these ideas, we introduced kinase-activating mutations after Lox-P sites in the mouse Stk39 gene, which encodes the terminal kinase in the WNK signaling pathway, Ste20-related proline-alanine-rich kinase (SPAK)...
April 25, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28437192/phototoxicity-of-vascular-endothelial-cells-caused-by-contact-with-talaporfin-sodium-for-15-120-min-in-vitro-and-in-vivo-studies
#10
Risa Hamada, Emiyu Ogawa, Tsunenori Arai
OBJECTIVE: To reveal the mechanism of vascular patency in the myocardium after photosensitization immediately after talaporfin sodium (TS) injection in a canine model, we investigated acute injury to vascular endothelial cells (VECs) in vitro and in vivo. BACKGROUND DATA: There are many reports of vascular shutdown within the target region in photodynamic therapy with TS. Vascular patency within healthy canine myocardium in which a photosensitization reaction starts immediately after injection of TS has been reported...
February 22, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28431046/brg1-interacts-with-sox10-to-establish-the-melanocyte-lineage-and-to-promote-differentiation
#11
Himangi G Marathe, Dawn E Watkins-Chow, Matthias Weider, Alana Hoffmann, Gaurav Mehta, Archit Trivedi, Shweta Aras, Tupa Basuroy, Aanchal Mehrotra, Dorothy C Bennett, Michael Wegner, William J Pavan, Ivana L de la Serna
Mutations in SOX10 cause neurocristopathies which display varying degrees of hypopigmentation. Using a sensitized mutagenesis screen, we identified Smarca4 as a modifier gene that exacerbates the phenotypic severity of Sox10 haplo-insufficient mice. Conditional deletion of Smarca4 in SOX10 expressing cells resulted in reduced numbers of cranial and ventral trunk melanoblasts. To define the requirement for the Smarca4 -encoded BRG1 subunit of the SWI/SNF chromatin remodeling complex, we employed in vitro models of melanocyte differentiation in which induction of melanocyte-specific gene expression is closely linked to chromatin alterations...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28414128/impaired-degradation-of-medullary-wnk4-in-the-kidneys-of-klhl2-knockout-mice
#12
Yuri Kasagi, Daiei Takahashi, Tomomi Aida, Hidenori Nishida, Naohiro Nomura, Moko Zeniya, Takayasu Mori, Emi Sasaki, Fumiaki Ando, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
Mutations in the with-no-lysine kinase 1 (WNK1), WNK4, Kelch-like 3 (KLHL3), and Cullin3 (CUL3) genes were identified as being responsible for hereditary hypertensive disease pseudohypoaldosteronism type II (PHAII). Normally, the KLHL3/CUL3 ubiquitin ligase complex degrades WNKs. In PHAII, the loss of interaction between KLHL3 and WNK4 increases levels of WNKs because of impaired ubiquitination, leading to abnormal over-activation of the WNK-OSR1/SPAK-NCC cascade in the kidney's distal convoluted tubules (DCT)...
April 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28397803/tomatidine-enhances-lifespan-and-healthspan-in-c-elegans-through-mitophagy-induction-via-the-skn-1-nrf2-pathway
#13
Evandro F Fang, Tyler B Waltz, Henok Kassahun, Qiping Lu, Jesse S Kerr, Marya Morevati, Elayne M Fivenson, Bradley N Wollman, Krisztina Marosi, Mark A Wilson, Wendy B Iser, D Mark Eckley, Yongqing Zhang, Elin Lehrmann, Ilya G Goldberg, Morten Scheibye-Knudsen, Mark P Mattson, Hilde Nilsen, Vilhelm A Bohr, Kevin G Becker
Aging is a major international concern that brings formidable socioeconomic and healthcare challenges. Small molecules capable of improving the health of older individuals are being explored. Small molecules that enhance cellular stress resistance are a promising avenue to alleviate declines seen in human aging. Tomatidine, a natural compound abundant in unripe tomatoes, inhibits age-related skeletal muscle atrophy in mice. Here we show that tomatidine extends lifespan and healthspan in C. elegans, an animal model of aging which shares many major longevity pathways with mammals...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28392346/uchl1-regulates-melanogenesis-through-controlling-mitf-stability-in-human-melanocytes
#14
Eun Young Seo, Seon-Pil Jin, Kyung-Cheol Sohn, Chi-Hyun Park, Dong Hun Lee, Jin Ho Chung
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is involved in many signaling pathways via the ubiquitin-proteasome system. UCHL1 is expressed in the human skin and serves as a neuronal marker; however, its functions in melanogenesis remain unknown. Here, we investigated the role of UCHL1 in melanogenesis, and elucidated the underlying mechanism using human melanocytes. UCHL1 downregulation by siRNA resulted in upregulation of microphthalmia-associated transcription factor (MITF), tyrosinase, dopachrome tautomerase (DCT), tyrosinase-related protein 1 (TRP-1), and melanin...
April 6, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28391819/automatic-gender-determination-from-3d-digital-maxillary-tooth-plaster-models-based-on-the-random-forest-algorithm-and-discrete-cosine-transform
#15
Betül Akkoç, Ahmet Arslan, Hatice Kök
BACKGROUND AND OBJECTIVE: One of the first stages in the identification of an individual is gender determination. Through gender determination, the search spectrum can be reduced. In disasters such as accidents or fires, which can render identification somewhat difficult, durable teeth are an important source for identification. This study proposes a smart system that can automatically determine gender using 3D digital maxillary tooth plaster models. METHODS: The study group was composed of 40 Turkish individuals (20 female, 20 male) between the ages of 21 and 24...
May 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28389400/comparison-in-docetaxel-loaded-nanoparticles-based-on-three-different-carboxymethyl-chitosans
#16
Enhui Zhang, Ronge Xing, Song Liu, Kecheng Li, Yukun Qin, Huahua Yu, Pengcheng Li
In this study, three different carboxymethyl chitosans (CMCs), namely O-carboxymethyl chitosan (OC), N-carboxymethyl chitosan (NC) and N,O-carboxymethyl chitosan (NOC), were prepared as nano-carriers for an anti-tumor drug, docetaxel (DCT). Three CMCs were fabricated into drug-loading nanoparticles under different preparing conditions respectively. A series of characterization parameters were determined including drug loading capacity (DC), entrapment efficiency (EE), particle size distribution, zeta potential, and morphology, which were used to find the optimized preparing condition for three kinds of nanoparticles (NPs)...
April 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28381053/lithographic-source-optimization-based-on-adaptive-projection-compressive-sensing
#17
Xu Ma, Dongxiang Shi, Zhiqiang Wang, Yanqiu Li, Gonzalo R Arce
This paper proposes to use the a-priori knowledge of the target layout patterns to design data-adaptive compressive sensing (CS) methods for efficient source optimization (SO) in lithography systems. A set of monitoring pixels are selected from the target layout based on blue noise random patterns. The SO is then formulated as an under-determined linear problem to improve image fidelity according to the monitoring pixels. Adaptive projections are then designed, based on the a-priori knowledge of the target layout, in order to further reduce the dimension of the optimization problem, while trying to retain the SO performance...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28365586/enac-and-romk-activity-are-inhibited-in-the-dct2-cnt-of-tgwnk4-phaii-mice
#18
Chengbiao Zhang, Lijun Wang, Xiao-Tong Su, Junhui Zhang, Dao-Hong Lin, Wen-Hui Wang
Mice transgenic for genomic segments harboring PHAII (pseudohypoaldosteronism type II) mutant Wnk4 (with-No-Lysine kinase 4) (TgWnk4(PHAII)) have hyperkalemia which is currently believed to be the result of high activity of Na-Cl cotransporter (NCC). This leads to decreasing Na(+) delivery to the distal nephron segment including late distal convoluted tubule (DCT) and connecting tubule (CNT). Since epithelial Na(+) channel (ENaC) and renal outer medullary K(+) channel (ROMK or Kir4.1) are expressed in the late DCT and play an important role in mediating K(+) secretion, the aim of the present study is to test whether ROMK and ENaC activity in the DCT/CNT are also compromised in the mice expressing PHAII mutant Wnk4...
April 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28356287/pgf2%C3%AE-regulates-the-basolateral-k-channels-in-the-distal-convoluted-tubule-dct
#19
Lijun Wang, Chengbiao Zhang, Xiao-Tong Su, Dao-Hong Lin, Peng Wu, Michal Laniado Schwartzman, Wen-Hui Wang
We aim to examine the role of PGF2α receptor (FP), a highly expressed prostaglandin receptor in the DCT, in regulating basolateral 40 pS K channel. The single channel studies demonstrated that PGF2α had a biphasic effect on the 40 pS K channel in the DCT: PGF2α stimulated at low concentrations (less than 500 nM) while at high concentrations (above 1µM) it inhibited the 40 pS K channels. Moreover, neither 13,14-dihydro-15-keto-PGF2α (a metabolite of PGF2α) nor PGE2 was able to mimic the effect of PGF2α on the 40 pS K channel in the DCT...
March 29, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28356087/evaluation-of-ocular-pulse-amplitude-in-non-arteritic-anterior-ischaemic-optic-neuropathy
#20
Durgul Acan, Omer Karti, Tuncay Kusbeci
BACKGROUND: To evaluate the ocular pulse amplitude (OPA) in patients with chronic non-arteritic anterior ischaemic optic neuropathy (NAION). METHODS: This cross-sectional study comprised a study group of 30 eyes from 30 patients with NAION and a control group of 31 eyes from 31 age and gender-matched healthy subjects. Bilateral OPA was measured with dynamic contour tonometry (DCT) and was compared between the study and control groups. RESULTS: No statistically significant difference was found between the study and control groups in terms of hypertension, diabetes mellitus, ischaemic heart disease and hyperlipidemia...
March 29, 2017: BMC Ophthalmology
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