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Lepidium meyenii

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https://www.readbyqxmd.com/read/28635053/protective-effects-of-lepidium-meyenii-maca-aqueous-extract-and-lycopene-on-testosterone-propionate-induced-prostatic-hyperplasia-in-mice
#1
Ying Zou, Waleed Aboshora, Jing Li, Tiancun Xiao, Lianfu Zhang
The inhibitory effect of maca extractant, lycopene, and their combination was evaluated in benign prostatic hyperplasia (BPH) mice induced by testosterone propionate. Mice were divided into a saline group, solvent control group and testosterone propionate-induced BPH mice [BPH model group, solvent BPH model group, benzyl glucosinolate group (1.44 mg/kg), maca group (60 mg/kg), lycopene treated (15, 5, and 2.5 mg/kg), maca (30 mg/kg) combine lycopene treated (7.5, 2.5, and 1.25 mg/kg), and finasteride treated]...
June 20, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28577982/purification-characterization-and-biological-activities-of-a-polysaccharide-from-lepidium-meyenii-leaves
#2
Shufang Li, Limin Hao, Qiaozhen Kang, Yinxin Cui, Hui Jiang, Xin Liu, Jike Lu
The characteristics and biological activities of a novel polysaccharide from Lepidium meyenii leaves (LMLP) were investigated. LMLP was purified using DEAE-52 cellulose chromatography followed by SephadexG-100 chromatography. The average molecule weight of LMLP was 58.43kDa and it was composed of galactose, arabinose, rhamnose, glucose and mannose with a relative molar ratio of 5.51:4.05:1.15:0.77:0.01. Antioxidant activity results showed that LMLP presented an EC50 of 3.72mg/mL in scavenging 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical, and it also had reducing power (OD700nm being 0...
May 31, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28560642/identification-and-characterization-of-micrornas-and-their-targets-in-high-altitude-stress-adaptive-plant-maca-lepidium-meyenii-walp
#3
Sujay Paul
MicroRNAs (miRNAs) are endogenous, short (~21-nucleotide), non-coding RNA molecules that play pivotal roles in plant growth, development, and stress response signaling. In this study using recently published draft genome sequence of a high-altitude plant maca (Lepidium meyenii Walp) and applying genome-wide computational-based approaches, a total of 62 potentially conserved miRNAs belonging to 28 families were identified and four (lme-miR160a, lme-miR164c, lme-miR 166a, and lme-miR 319a) of them further validated by RT-PCR...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28472063/occurrence-of-urea-based-soluble-epoxide-hydrolase-inhibitors-from-the-plants-in-the-order-brassicales
#4
Seiya Kitamura, Christophe Morisseau, Todd R Harris, Bora Inceoglu, Bruce D Hammock
Recently, dibenzylurea-based potent soluble epoxide hydrolase (sEH) inhibitors were identified in Pentadiplandra brazzeana, a plant in the order Brassicales. In an effort to generalize the concept, we hypothesized that plants that produce benzyl glucosinolates and corresponding isothiocyanates also produce these dibenzylurea derivatives. Our overall aim here was to examine the occurrence of urea derivatives in Brassicales, hoping to find biologically active urea derivatives from plants. First, plants in the order Brassicales were analyzed for the presence of 1, 3-dibenzylurea (compound 1), showing that three additional plants in the order Brassicales produce the urea derivatives...
2017: PloS One
https://www.readbyqxmd.com/read/28304399/chemical-profiling-analysis-of-maca-using-uhplc-esi-orbitrap-ms-coupled-with-uhplc-esi-qqq-ms-and-the-neuroprotective-study-on-its-active-ingredients
#5
Yanyan Zhou, Peng Li, Adelheid Brantner, Hongjie Wang, Xinbin Shu, Jian Yang, Nan Si, Lingyu Han, Haiyu Zhao, Baolin Bian
Lepidium meyenii (Maca), originated from Peru, has been cultivated widely in China as a popular health care food. However, the chemical and effective studies of Maca were less in-depth, which restricted its application seriously. To ensure the quality of Maca, a feasible and accurate strategy was established. One hundred and sixty compounds including 30 reference standards were identified in 6 fractions of methanol extract of Maca by UHPLC-ESI-Orbitrap MS. Among them, 15 representative active compounds were simultaneously determined in 17 samples by UHPLC-ESI-QqQ MS...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28295471/long-term-feeding-of-hydroalcoholic-extract-powder-of-lepidium-meyenii-maca-enhances-the-steroidogenic-ability-of-leydig-cells-to-alleviate-its-decline-with-ageing-in-male-rats
#6
K Yoshida, Y Ohta, N Kawate, M Takahashi, T Inaba, S Hatoya, H Morii, K Takahashi, M Ito, H Tamada
This study examined whether feeding hydroalcoholic extract of Lepidium meyenii (maca) to 8-week-old (sexually maturing) or 18-week-old (mature) male rats for more than a half year affects serum testosterone concentration and testosterone production by Leydig cells cultured with hCG, 22R-hydroxycholesterol or pregnenolone. Testosterone concentration was determined in the serum samples obtained before and 6, 12, 18 and 24 weeks after the feeding, and it was significantly increased only at the 6 weeks in the group fed with the maca extract to maturing rats when it was compared with controls...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28261840/feeding-hydroalcoholic-extract-powder-of-lepidium-meyenii-maca-enhances-testicular-gene-expression-of-3%C3%AE-hydroxysteroid-dehydrogenase-in-rats
#7
Y Ohta, N Kawate, T Inaba, H Morii, K Takahashi, H Tamada
Although feeding diets containing the extract powder of Lepidium meyenii (maca), a plant growing in Peru's Central Andes, increases serum testosterone concentration associated with enhanced ability of testosterone production by Leydig cells in male rats, changes in testicular steroidogenesis-related factors by the maca treatment are not known. This study examined the effects of maca on testicular gene expressions for luteinizing hormone receptor, steroidogenic acute regulatory protein and steroidogenic enzymes...
March 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28231388/structural-characterization-and-antifatigue-effect-in-vivo-of-maca-lepidium-meyenii-walp-polysaccharide
#8
Weimin Tang, Lu Jin, Lianghua Xie, Juqing Huang, Nan Wang, Bingquan Chu, Xulin Dai, Yu Liu, Rui Wang, Ying Zhang
Maca (Lepidium meyenii Walp) polysaccharides (MP) with purity of 99.2% were obtained to investigate their structural characteristics and antifatigue effect in vivo. The physicochemical properties of MP were analyzed through high-performance gel filtration chromatography, IR, monosaccharide composition, methylation, GC-MS, and NMR analyses. The antifatigue effect of MP was evaluated by using a mouse weight-loaded swimming model. MP is an acidic heteropolysaccharide with an average molecular weight (Mw ) of 793...
March 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28212012/-meyeniins-a-c-novel-hexahydroimidazo-1-5-c-thiazole-derivatives-from-the-tubers-of-lepidium-meyenii-complete-structural-elucidation-by-biomimetic-synthesis-and-racemic-crystallization
#9
Min Zhou, Hang-Ying Ma, Zhi-Hua Liu, Guang-Yu Yang, Gang Du, Yan-Qing Ye, Gan-Peng Li, Qiu-Fen Hu
(+)-Meyeniins A-C (1-3), a novel class of sulfur-containing hexahydroimidazo[1,5-c]thiazole derivatives, were isolated from the tubers of Lepidium meyenii (maca) cultivated in Lijiang, Yunnan province, China. Guided by their biosynthetic hypothesis, a stereocontrolled biomimetic synthesis of meyeniins A-C and their individual enantiomers was efficiently accomplished by a combination of a condensation reaction and Edman degradation. The formation of high-quality crystals for X-ray crystallography occurred much more readily from a racemic mixture of (±)-meyeniin A than with the single enantiomer alone in this case...
March 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28174084/protective-effect-of-polysaccharide-from-maca-lepidium-meyenii-on-hep-g2-cells-and-alcoholic-liver-oxidative-injury-in-mice
#10
Lijun Zhang, Qingsheng Zhao, Liwei Wang, Mingxia Zhao, Bing Zhao
To study the characterization and hepatoprotective activity of polysaccharide from maca (Lepidium meyenii), the main polysaccharide from maca (MP-1) was obtained by DEAE-52 cellulose column. The average molecular weight of MP-1 was 1067.3kDa and the polysaccharide purity was 91.63%. In order to assess the antioxidant activities of MP-1, four kinds of methods were used, including scavenging hydroxyl radical, DPPH, superoxide anion radical, and FRAP, and the results indicated high antioxidant activities. Furthermore, hepatoprotective activity of MP-1 was studied both in vitro and vivo...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28117590/structural-characterization-of-a-novel-polysaccharide-from-lepidium-meyenii-maca-and-analysis-of-its-regulatory-function-in-macrophage-polarization-in-vitro
#11
Mengmeng Zhang, Wenjia Wu, Yao Ren, Xiaofeng Li, Yuqian Tang, Tian Min, Furao Lai, Hui Wu
In our previous study, three novel polysaccharides, named MC-1, MC-2, and MC-3, were separated from the roots of maca (Lepidium meyenii), which is a food source from the Andes region. The structural information and immunomodulatory activity of MC-1 were then investigated. The structure and activity of MC-2 are still unknown. In this study, structural characterization revealed that MC-2 has an average molecular weight of 9.83 kDa and is composed of arabinose (20.9%), mannose (4.5%), glucose (71.9%), and galactose (2...
February 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28078724/application-of-multi-block-analysis-and-mixture-design-with-process-variable-for-development-of-chocolate-cake-containing-yacon-smallanthus-sonchifolius-and-maca-lepidium-meyenii
#12
Marcela Marta Lazaretti Tormena, Luana Tabalipa de Medeiros, Patrícia Casarin de Lima, Gabriela Possebon, Renata Hernandez Barros Fuchs, Evandro Bona
BACKGROUND: In this study, a chocolate cake formulation was developed with partial substitution of wheat flour by yacon and maca flour. A simplex-centroid design was applied to determine the proportions of the three flours, and the amount of water was included as a process variable at three distinct levels. According to the overall acceptability of the cakes, the tasters were separated into two groups using k-means. RESULTS: After segmentation, regression models were constructed for overall acceptability of each group; R(2)adjusted values of 92...
January 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28007001/antioxidant-and-neuroprotector-effect-of-lepidium-meyenii-maca-methanol-leaf-extract-against-6-hydroxy-dopamine-6-ohda-induced-toxicity-in-pc12-cells
#13
Ángel Rodríguez-Huamán, Sandra Casimiro-Gonzales, Jorge Antonio Chávez-Pérez, Carla Gonzales-Arimborgo, Richard Cisneros-Fernández, Luis Ángel Aguilar-Mendoza, Gustavo F Gonzales
Reactive oxygen species (ROS) are normally produced during cell metabolism, there is strong evidence to suggest that ROS produced in excess impair the cell and may be etiologically related to various neurodegenerative diseases. This study was undertaken to examine the effects of Lepidium meyenii (MACA) methanol leaf extract on neurotoxicity in PC12 cell exposed to 6-hydroxydopamine (6-OHDA). Fresh samples of "maca" leaves were processed in order to obtain foliar extracts and to evaluate the neurobiological activity on PC12 cells, subjected to the cytotoxic effect of 6-OHDA through the determination of the capacity antioxidant, cell viability and cytotoxicity assays on PC12 cells...
May 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27719949/physicochemical-properties-of-maca-starch
#14
Ling Zhang, Guantian Li, Sunan Wang, Weirong Yao, Fan Zhu
Maca (Lepidium meyenii Walpers) is gaining research attention due to its unique bioactive properties. Starch is a major component of maca roots, thus representing a novel starch source. In this study, the properties of three maca starches (yellow, purple and black) were compared with commercially maize, cassava, and potato starches. The starch granule sizes ranged from 9.0 to 9.6μm, and the granules were irregularly oval. All the maca starches presented B-type X-ray diffraction patterns, with the relative degree of crystallinity ranging from 22...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27708692/in-silico-profiling-for-secondary-metabolites-from-lepidium-meyenii-maca-by-the-pharmacophore-and-ligand-shape-based-joint-approach
#15
Fan Yi, Xiao-Lei Tan, Xin Yan, Hai-Bo Liu
BACKGROUND: Lepidium meyenii Walpers (maca) is an herb known as a traditional nutritional supplement and widely used in Peru, North America, and Europe to enhance human fertility and treat osteoporosis. The secondary metabolites of maca, namely, maca alkaloids, macaenes, and macamides, are bioactive compounds, but their targets are undefined. METHODS: The pharmacophore-based PharmaDB targets database screening joint the ligand shape similarity-based WEGA validation approach is proposed to predict the targets of these unique constituents and was performed using Discovery Studio 4...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27681650/effect-of-lepidium-meyenii-maca-on-testicular-function-of-mice-with-chemically-and-physically-induced-subfertility
#16
M Valdivia Cuya, K Yarasca De La Vega, G Lévano Sánchez, J Vásquez Cavero, H Temoche García, L Torres Torres, V Cruz Ornetta
The aim of this study was to evaluate the effect of Lepidium meyenii (maca) in chemically and physically subfertile mice. After 35 days, the following groups of mice were evaluated: control, sham, chemical subfertility, chemical subfertility-maca-supplemented, physical subfertility, physical subfertility-maca-supplemented and maca-supplemented only. Motility (32.36% ± 5.34%) and sperm count (44.4 ± 5.37 × 10(6) /ml) in the chemically and physically subfertile mice (11.81% ± 4.06%, 17.34 ± 13...
October 2016: Andrologia
https://www.readbyqxmd.com/read/27681649/red-maca-lepidium-meyenii-did-not-affect-cell-viability-despite-increased-androgen-receptor-and-prostate-specific-antigen-gene-expression-in-the-human-prostate-cancer-cell-line-lncap
#17
P Díaz, H Cardenas, P A Orihuela
We examined whether aqueous extract of Lepidium meyenii (red Maca) could inhibit growth, potentiate apoptotic activity of two anticancer drugs Taxol and 2-methoxyestradiol (2ME) or change mRNA expression for the androgen target genes, androgen receptor (Ar) and prostate-specific antigen (Psa) in the human prostate cancer cell line LNCaP. Red Maca aqueous extract at 0, 10, 20, 40 or 80 μg/ml was added to LNCaP cells, and viability was evaluated by the MTS assay at 24 or 48 hr after treatment. Furthermore, LNCaP cells were treated with 80 μg/ml of red Maca plus Taxol or 2ME 5 μM and viability was assessed 48 hr later...
October 2016: Andrologia
https://www.readbyqxmd.com/read/27681648/effect-of-butanolic-fraction-of-yellow-and-black-maca-lepidium-meyenii-on-the-sperm-count-of-adult-mice
#18
N Inoue, C Farfan, G F Gonzales
Lepidium meyenii, known as maca, is a popular nutraceutical food which is grown over 4,000 m above sea level in the Peruvian central highlands. Maca contains alkaloids, but there are no studies on their biological effects. The butanol fraction obtained from methanol extract of maca hypocotyls contains alkaloids. The effects of butanol/aqueous fractions partitioned from methanol extract of yellow and black maca were examined. Total phenolic content (TPC) and antioxidant capacity by 2,2'-diphenyl-1-picrylhydrazyl were used to evaluate maca fractions in vitro...
October 2016: Andrologia
https://www.readbyqxmd.com/read/27648102/preservation-of-cognitive-function-by-lepidium-meyenii-maca-is-associated-with-improvement-of-mitochondrial-activity-and-upregulation-of-autophagy-related-proteins-in-middle-aged-mouse-cortex
#19
Shan-Shan Guo, Xiao-Fang Gao, Yan-Rong Gu, Zhong-Xiao Wan, A-Ming Lu, Zheng-Hong Qin, Li Luo
Maca has been used as a foodstuff and a traditional medicine in the Andean region for over 2,000 years. Recently the neuroprotective effects of maca also arouse interest of researchers. Decrease in mitochondrial function and decline in autophagy signaling may participate in the process of age-related cognitive decline. This study aimed to investigate if maca could improve cognitive function of middle-aged mice and if this effect was associated with improvement of mitochondrial activity and modulation of autophagy signaling in mouse cortex...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27621241/the-use-of-maca-lepidium-meyenii-to-improve-semen-quality-a-systematic-review
#20
REVIEW
Myeong Soo Lee, Hye Won Lee, Sooseong You, Ki-Tae Ha
The aim of this review was to assess the evidence for the effectiveness of maca (Lepidium meyenii) in improving semen quality. We searched 11 databases from their inception to March 2016 and included all clinical trials on the improvement of semen quality parameters in infertile and healthy men, regardless of the study design or the type of maca. The risk of bias for each study was assessed using the Cochrane criteria. The selection of studies, data extraction, and validation were performed independently by the first two authors...
October 2016: Maturitas
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