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Lepidium meyenii

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https://www.readbyqxmd.com/read/27719949/physicochemical-properties-of-maca-starch
#1
Ling Zhang, Guantian Li, Sunan Wang, Weirong Yao, Fan Zhu
Maca (Lepidium meyenii Walpers) is gaining research attention due to its unique bioactive properties. Starch is a major component of maca roots, thus representing a novel starch source. In this study, the properties of three maca starches (yellow, purple and black) were compared with commercially maize, cassava, and potato starches. The starch granule sizes ranged from 9.0 to 9.6μm, and the granules were irregularly oval. All the maca starches presented B-type X-ray diffraction patterns, with the relative degree of crystallinity ranging from 22...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27708692/in-silico-profiling-for-secondary-metabolites-from-lepidium-meyenii-maca-by-the-pharmacophore-and-ligand-shape-based-joint-approach
#2
Fan Yi, Xiao-Lei Tan, Xin Yan, Hai-Bo Liu
BACKGROUND: Lepidium meyenii Walpers (maca) is an herb known as a traditional nutritional supplement and widely used in Peru, North America, and Europe to enhance human fertility and treat osteoporosis. The secondary metabolites of maca, namely, maca alkaloids, macaenes, and macamides, are bioactive compounds, but their targets are undefined. METHODS: The pharmacophore-based PharmaDB targets database screening joint the ligand shape similarity-based WEGA validation approach is proposed to predict the targets of these unique constituents and was performed using Discovery Studio 4...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27681650/effect-of-lepidium-meyenii-maca-on-testicular-function-of-mice-with-chemically-and-physically-induced-subfertility
#3
M Valdivia Cuya, K Yarasca De La Vega, G Lévano Sánchez, J Vásquez Cavero, H Temoche García, L Torres Torres, V Cruz Ornetta
The aim of this study was to evaluate the effect of Lepidium meyenii (maca) in chemically and physically subfertile mice. After 35 days, the following groups of mice were evaluated: control, sham, chemical subfertility, chemical subfertility-maca-supplemented, physical subfertility, physical subfertility-maca-supplemented and maca-supplemented only. Motility (32.36% ± 5.34%) and sperm count (44.4 ± 5.37 × 10(6) /ml) in the chemically and physically subfertile mice (11.81% ± 4.06%, 17.34 ± 13...
October 2016: Andrologia
https://www.readbyqxmd.com/read/27681649/red-maca-lepidium-meyenii-did-not-affect-cell-viability-despite-increased-androgen-receptor-and-prostate-specific-antigen-gene-expression-in-the-human-prostate-cancer-cell-line-lncap
#4
P Díaz, H Cardenas, P A Orihuela
We examined whether aqueous extract of Lepidium meyenii (red Maca) could inhibit growth, potentiate apoptotic activity of two anticancer drugs Taxol and 2-methoxyestradiol (2ME) or change mRNA expression for the androgen target genes, androgen receptor (Ar) and prostate-specific antigen (Psa) in the human prostate cancer cell line LNCaP. Red Maca aqueous extract at 0, 10, 20, 40 or 80 μg/ml was added to LNCaP cells, and viability was evaluated by the MTS assay at 24 or 48 hr after treatment. Furthermore, LNCaP cells were treated with 80 μg/ml of red Maca plus Taxol or 2ME 5 μM and viability was assessed 48 hr later...
October 2016: Andrologia
https://www.readbyqxmd.com/read/27681648/effect-of-butanolic-fraction-of-yellow-and-black-maca-lepidium-meyenii-on-the-sperm-count-of-adult-mice
#5
N Inoue, C Farfan, G F Gonzales
Lepidium meyenii, known as maca, is a popular nutraceutical food which is grown over 4,000 m above sea level in the Peruvian central highlands. Maca contains alkaloids, but there are no studies on their biological effects. The butanol fraction obtained from methanol extract of maca hypocotyls contains alkaloids. The effects of butanol/aqueous fractions partitioned from methanol extract of yellow and black maca were examined. Total phenolic content (TPC) and antioxidant capacity by 2,2'-diphenyl-1-picrylhydrazyl were used to evaluate maca fractions in vitro...
October 2016: Andrologia
https://www.readbyqxmd.com/read/27648102/preservation-of-cognitive-function-by-lepidium-meyenii-maca-is-associated-with-improvement-of-mitochondrial-activity-and-upregulation-of-autophagy-related-proteins-in-middle-aged-mouse-cortex
#6
Shan-Shan Guo, Xiao-Fang Gao, Yan-Rong Gu, Zhong-Xiao Wan, A-Ming Lu, Zheng-Hong Qin, Li Luo
Maca has been used as a foodstuff and a traditional medicine in the Andean region for over 2,000 years. Recently the neuroprotective effects of maca also arouse interest of researchers. Decrease in mitochondrial function and decline in autophagy signaling may participate in the process of age-related cognitive decline. This study aimed to investigate if maca could improve cognitive function of middle-aged mice and if this effect was associated with improvement of mitochondrial activity and modulation of autophagy signaling in mouse cortex...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27621241/the-use-of-maca-lepidium-meyenii-to-improve-semen-quality-a-systematic-review
#7
REVIEW
Myeong Soo Lee, Hye Won Lee, Sooseong You, Ki-Tae Ha
The aim of this review was to assess the evidence for the effectiveness of maca (Lepidium meyenii) in improving semen quality. We searched 11 databases from their inception to March 2016 and included all clinical trials on the improvement of semen quality parameters in infertile and healthy men, regardless of the study design or the type of maca. The risk of bias for each study was assessed using the Cochrane criteria. The selection of studies, data extraction, and validation were performed independently by the first two authors...
October 2016: Maturitas
https://www.readbyqxmd.com/read/27618035/polyphenols-and-sunburn
#8
REVIEW
Suzana Saric, Raja K Sivamani
Polyphenols are antioxidant molecules found in many foods such as green tea, chocolate, grape seeds, and wine. Polyphenols have antioxidant, anti-inflammatory, and antineoplastic properties. Growing evidence suggests that polyphenols may be used for the prevention of sunburns as polyphenols decrease the damaging effects of ultraviolet A (UVA) and ultraviolet B (UVB) radiation on the skin. This review was conducted to examine the evidence for use of topically and orally ingested polyphenols in prevention of sunburns...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27548190/acceptability-safety-and-efficacy-of-oral-administration-of-extracts-of-black-or-red-maca-lepidium-meyenii-in-adult-human-subjects-a-randomized-double-blind-placebo-controlled-study
#9
Carla Gonzales-Arimborgo, Irma Yupanqui, Elsa Montero, Dulce E Alarcón-Yaquetto, Alisson Zevallos-Concha, Lidia Caballero, Manuel Gasco, Jianping Zhao, Ikhlas A Khan, Gustavo F Gonzales
The plant maca, grown at 4000 m altitude in the Peruvian Central Andes, contains hypocotyls that have been used as food and in traditional medicine for centuries. The aim of this research was to provide results on some health effects of oral administration of spray-dried extracts of black or red maca (Lepidium meyenii) in adult human subjects living at low (LA) and high altitude (HA). A total of 175 participants were given 3 g of either placebo, black, or red maca extract daily for 12 weeks. Primary outcomes were changes in sexual desire, mood, energy, health-related quality of life score (HRQL), and chronic mountain sickness (CMS) score, or in glycaemia, blood pressure, and hemoglobin levels...
August 18, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27174404/genome-of-plant-maca-lepidium-meyenii-illuminates-genomic-basis-for-high-altitude-adaptation-in-the-central-andes
#10
Jing Zhang, Yang Tian, Liang Yan, Guanghui Zhang, Xiao Wang, Yan Zeng, Jiajin Zhang, Xiao Ma, Yuntao Tan, Ni Long, Yangzi Wang, Yujin Ma, Yuqi He, Yu Xue, Shumei Hao, Shengchao Yang, Wen Wang, Liangsheng Zhang, Yang Dong, Wei Chen, Jun Sheng
Maca (Lepidium meyenii Walp, 2n = 8x = 64), belonging to the Brassicaceae family, is an economic plant cultivated in the central Andes sierra in Peru (4000-4500 m). Considering that the rapid uplift of the central Andes occurred 5-10 million years ago (Ma), an evolutionary question arises regarding how plants such as maca acquire high-altitude adaptation within a short geological period. Here, we report the high-quality genome assembly of maca, in which two closely spaced maca-specific whole-genome duplications (WGDs; ∼6...
July 6, 2016: Molecular Plant
https://www.readbyqxmd.com/read/27169179/bioactive-compounds-from-plants-used-in-peruvian-traditional-medicine
#11
REVIEW
Olga Lock, Eleucy Perez, Martha Villar, Diana Flores, Rosario Rojas
It is estimated that there are as many as 1400 plant species currently used in traditional Peruvian medicine; however, only a few have undergone scientific investigation. In this paper, we make a review of the botanical, chemical, pharmacological and clinical propierties of the most investigated Peruvian medicinal plants. The plant species selected for this review are: Smallanthus sonchifolius (yacon), Croton lechleri (sangre de grado), Uncaria tomentosa/U. guianensis (uña de gato), Lepidium meyenii (maca), Physalis peruviana (aguaymanto), Minthostachys mollis (muña), Notholaena nivea (cuti-cuti), Maytenus macrocarpa (chuchuhuasi), Dracontium loretense (jergon sacha), Gentianella nitida (hercampuri), Plukenetia volubilis (sacha inchi) and Zea mays (maiz morado)...
March 2016: Natural Product Communications
https://www.readbyqxmd.com/read/27141661/-determination-of-benzyl-glucosinolate-in-lepidium-meyenii-from-different-regions-by-hplc
#12
Lin Tang, Hong-jun Yin, Cong-cong Si, Xiao-yan Hu, Zheng-hai Long
The content of benzyl isothiocyanate (BITC) which as the enzymatic hydrolysis product of benzyl glucosinolate through thioglucosidase was determined by HPLC. The content of benzyl isothiocyanate (BITC) which as the enzymatic hydrolysis product of benzyl glucosinolate through thioglucosidase was determined by HPLC. The chromatography condition was as follows: Kaseisorb LC ODS 2000 (4.6 mm x 150 mm, 5 min) column with the mobile phase of acetonitrile(A)-water( B) under gradient elution (0-5 min, 3%-8% A; 5-9 min, 8%-48% A; 9-23 min, 48%-62% A; 23-28 min, 62%-99% A); the flow rate was 1...
December 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/27141660/-quality-control-of-maca-lepidium-meyenii
#13
Ji-cheng Shu, Hang-qing Cui, Ying-zheng Huang, Xiao-ying Huang, Ming Yang
To control the quality of Maca, the quality standard was established in this study. According to the methods recorded in the Appendix of Chinese Pharmacopoeia (2010 Edition), the water, extract, total ash, acid insoluble substance, and heavy metals inspections in Lepidium meyenii were carried out. N-benzyl-9Z, 12Z-octadecadienamide in L. meyenii was identified by TLC, and it was determined by HPLC. The results showed that the N-benzyl-9Z, 12Z-octadecadienamide identification of TLC was a strong mark and specificity...
December 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/27141659/-chemical-constituents-of-lepidium-meyenii
#14
Wen-juan Liang, Hong-bo Xu, Cai-yan Yang, Chang-an Geng, Zhang Xue-mei, Ji-jun Chen
To study the chemical constituents of Lepidium meyenii, the air-dried rhizome of L. meyenii was extracted with 70% EtOH. The extract was condensed to a small amount of volume and extracted with petroleum ether, EtOAc and n-BuOH, successively. The compounds were isolated and purified by column chromatography, and identified based on spectral analyses (1H-NMR, 13C-NMR, HRESIMS). Eighteen compounds were isolated from L. meyenii, including 7 alkaloids and 4 fatty acids and 7 other compounds. They were characterized as (3-hydroxybenzyl) carbamic acid(1), phenylmethanamine(2), N-benzylformamide (3), N-benzylacetamide (4), pyridin-4-ylmethanamine(5), n-(4-methoxybenzyl) aniline(6), uracil(7), succininc acid(8), decanedioic acid(9), n-hexa- decanoic acid methyl ester(10), heptanoic acid(11), solerole(12), pyromucic acid methyl ester(13), 5-hydroxymethyl-2-furancar- boxadehyde(14), 5-(methoxymethyl)-1H-pyrrole-2-carbaldehyde(15), 1,7-dihydroxy-2,3, 4-trimethoxyxanthone (16), 1,7-di- hydroxy-3,4- dimethoxy-xanthone(17), (+)-pinoresinol(18)...
December 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/27141658/-recent-researching-progress-of-lepidium-meyenii-maca
#15
Yan-yan Zhou, Hai-yu Zhao, Nan Si, Hong-jie Wang, Bao-lin Gian
Maca as one of the star products in the international health care market in recent years, had a wide range of application value and promoted to all over the world. However, the basic research of Maca was not deep, lack of systematic and clear efficacy studies. Market products hype its aphrodisiac effect, which greatly impact more systematic in-depth research and exploration. Therefore, this paper briefly summarizes advance research in recent years including the status quo of the resources, growth cultivation, phytochemical, pharmacological effect and other aspects, which can provide reference for rational development and utilization of Maca...
December 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/26883006/structural-characterization-and-immunomodulatory-activity-of-a-novel-polysaccharide-from-lepidium-meyenii
#16
Mengmeng Zhang, Guang Wang, Furao Lai, Hui Wu
A novel polysaccharide named as MC-1 was isolated from the roots of Lepidium meyenii using a water extraction method. Structural characterization revealed that MC-1 had an average molecular weight of 11.3 kDa and consisted of arabinose (26.21%), mannose (11.81%), glucose (53.66%), and galactose (8.32%). The main linkage types of MC-1 were proven to be (1 → 5)-α-L-Ara, (1 → 3)-α-L-Man, (1 → 2,6)-α-L-Man, (1 → )-α-D-Glc, (1 → 4)-α-D-Glc, (1 → 6)-α-D-Glc and (1 → 6)-β-D-Gal by methylation analysis, periodate oxidation-Smith degradation and NMR analysis...
March 9, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/26857797/characteristic-fingerprinting-based-on-macamides-for-discrimination-of-maca-lepidium-meyenii-by-lc-ms-ms-and-multivariate-statistical-analysis
#17
Yu Pan, Ji Zhang, Hong Li, Yuan-Zhong Wang, Wan-Yi Li
BACKGROUND: Macamides with a benzylalkylamide nucleus are characteristic and major bioactive compounds in the functional food maca (Lepidium meyenii Walp). The aim of this study was to explore variations in macamide content among maca from China and Peru. Twenty-seven batches of maca hypocotyls with different phenotypes, sampled from different geographical origins, were extracted and profiled by liquid chromatography with ultraviolet detection/tandem mass spectrometry (LC-UV/MS/MS). RESULTS: Twelve macamides were identified by MS operated in multiple scanning modes...
October 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/26633045/effect-of-gamma-irradiation-on-phenol-content-antioxidant-activity-and-biological-activity-of-black-maca-and-red-maca-extracts-lepidium-meyenii-walp
#18
A Zevallos-Concha, D Nuñez, M Gasco, C Vasquez, M Quispe, G F Gonzales
This study was performed to determine the effects of gamma irradiation on UV spectrum on maca, total content of polyphenols, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activities and in vivo biological activities of red and black maca extracts (Lepidium meyenii). Adult mice of the strain Swiss aged 3 months and weighing 30-35 g in average were used to determine biological activities. Daily sperm production, effect on testosterone-induced prostate hyperplasia and forced swimming test were used to determine the effect of irradiation on biological activities of maca extracts...
2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/26453017/effects-of-macamides-on-endurance-capacity-and-anti-fatigue-property-in-prolonged-swimming-mice
#19
Qin Yang, Wenwen Jin, Xueyuan Lv, Pengfei Dai, Yanxiao Ao, Mengying Wu, Wenjing Deng, Longjiang Yu
CONTEXT: Lepidium meyenii Walp. (Brassicaceae), most commonly known as "maca", has been used as a food or folk medicine to improve vitality in Peru. Previous research demonstrated that lipid-soluble extract from maca improved swimming endurance capacity. Macamides are considered the typical lipid-soluble markers for maca and proved to have several pharmacological properties, such as improving sexual performance and neuroprotective activies. OBJECTIVE: The present study investigates the effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice...
2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/26421049/effect-of-lepidium-meyenii-walp-on-semen-parameters-and-serum-hormone-levels-in-healthy-adult-men-a-double-blind-randomized-placebo-controlled-pilot-study
#20
Ingrid Melnikovova, Tomas Fait, Michaela Kolarova, Eloy C Fernandez, Luigi Milella
Background/Aims. Products of Lepidium meyenii Walp. (maca) are touted worldwide as an alimentary supplement to enhance fertility and restore hormonal balance. Enhancing properties of maca on semen parameters in animals were previously reported by various authors, but we present to the best of our knowledge the first double-blind, randomized, placebo-controlled pilot trial in men. The aim of this study was to evaluate the effects of maca on semen parameters and serum hormone levels in healthy adult men. Methods...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
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