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Lepidium meyenii

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https://www.readbyqxmd.com/read/29681858/aqueous-extract-of-black-maca-prevents-metabolism-disorder-via-regulating-the-glycolysis-gluconeogenesis-tca-cycle-and-ppar%C3%AE-signaling-activation-in-golden-hamsters-fed-a-high-fat-high-fructose-diet
#1
Wenting Wan, Hongxiang Li, Jiamei Xiang, Fan Yi, Lijia Xu, Baoping Jiang, Peigen Xiao
Maca ( Lepidium meyenii Walpers) has been used as a dietary supplement and ethnomedicine for centuries. Recently, maca has become a high profile functional food worldwide because of its multiple biological activities. This study is the first explorative research to investigate the prevention and amelioration capacity of the aqueous extract of black maca (AEM) on high-fat, high-fructose diet (HFD)-induced metabolism disorder in golden hamsters and to identify the potential mechanisms involved in these effects...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29568754/monoamine-oxidase-a-inhibition-and-associated-antioxidant-activity-in-plant-extracts-with-potential-antidepressant-actions
#2
Tomás Herraiz, Hugo Guillén
Monoamine oxidase (MAO) catalyzes the oxidative deamination of amines and neurotransmitters and is involved in mood disorders, depression, oxidative stress, and adverse pharmacological reactions. This work studies the inhibition of human MAO-A by Hypericum perforatum , Peganum harmala, and Lepidium meyenii, which are reported to improve and affect mood and mental conditions. Subsequently, the antioxidant activity associated with the inhibition of MAO is determined in plant extracts for the first time. H. perforatum inhibited human MAO-A, and extracts from flowers gave the highest inhibition (IC50 of 63...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29544368/structure-analysis-and-anti-fatigue-activity-of-a-polysaccharide-from-lepidium-meyenii-walp
#3
Yun Tang, Zhen-Yuan Zhu, Li-Chao Pan, Huiqing Sun, Qiao-Ying Song, Yongmin Zhang
A polysaccharide was obtained from Lepidium meyenii Walp by hot water extraction and purification by Millipore (100 kD) and Sephadex G-200. The content of polysaccharide was examined to be 89.9% with phenol-sulfuric acid method. Its average molecular weight was estimated to be 2.213 × 106  Da by High Performance Gel Permeation Chromatography (HPGPC). Monosaccharide analysis showed that the polysaccharide was composed of arabinose, mannose, glucose and galactose with the molar ratio of 2.134: 1: 2.78: 2...
March 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29524221/postharvest-ultrasound-assisted-freeze-thaw-pretreatment-improves-the-drying-efficiency-physicochemical-properties-and-macamide-biosynthesis-of-maca-lepidium-meyenii
#4
Jin-Jin Chen, Peng-Fei Gong, Yi-Lan Liu, Bo-Yan Liu, Dawn Eggert, Yuan-Heng Guo, Ming-Xia Zhao, Qing-Sheng Zhao, Bing Zhao
A novel technique of ultrasound-assisted freeze-thaw pretreatment (UFP) was developed to improve the drying efficiency of maca and bioactive amide synthesis in maca. The optimal UFP conditions are ultrasonic processing 90 min at 30 °C with 6 freeze-thaw cycles. Samples with freeze-thaw pretreatment (FP), ultrasound pretreatment (UP), and UFP were prepared for further comparative study. A no pretreatment (NP) sample was included as a control. The results showed that UFP improved the drying efficiency of maca slices, showing the highest effective moisture diffusivity (1...
April 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29359412/influences-of-dietary-supplementation-with-lepidium-meyenii-maca-on-stallion-sperm-production-and-on-preservation-of-sperm-quality-during-storage-at-5-%C3%A2-c
#5
C Del Prete, S Tafuri, F Ciani, M P Pasolini, F Ciotola, S Albarella, D Carotenuto, V Peretti, N Cocchia
Stallion semen is damaged by oxidative stress during cooling and transport. Semen processing and extenders have been tested to improve the fertilizing capacity of semen and to preserve semen during transport. Dietary supplementation with natural antioxidants has been proposed to prevent oxidative damages. In this study, for the first time, the effect of dietary supplementation with Lepidium meyenii (Maca) on the characteristics of fresh and chilled stallion semen was evaluated. Maca is a traditional Andean crop used as a nutraceutical for the fertility-enhancing properties that are linked with antioxidant activity...
March 2018: Andrology
https://www.readbyqxmd.com/read/29353155/isolation-purification-structural-characterization-and-immunostimulatory-activity-of-water-soluble-polysaccharides-from-lepidium-meyenii
#6
Zhengqi Zha, Su-Yan Wang, Weihua Chu, Yang Lv, Hongjin Kan, Qiuli Chen, Lili Zhong, Long Yue, Jinna Xiao, Ying Wang, Hongping Yin
A water-soluble polysaccharide LMP-1 was isolated and purified by ion-exchange chromatography from maca (Lepidium meyenii Walp.). LMP-1 has a molecular weight of 1.01 × 104  Da, and is composed of glucose and arabinose with a molar ratio of 7.03:1.08. Methylation and the 1D and 2D NMR spectroscopy of LMP-1 revealed that it is mainly composed of →4)-α-D-Glcp-(1→, →6)-α-D-Glcp-(1→, →3)-α-D-Glcp-(1→, and β-D-Araf-(1→, with branching at O-6 of →4,6)-α-D-Glcp-(1 → . LMP-1 showed up-regulation of Toll-like receptor 4 (TLR4) and Toll-like receptor 2 (TLR2)...
March 2018: Phytochemistry
https://www.readbyqxmd.com/read/29341924/maca-polysaccharides-a-review-of-compositions-isolation-therapeutics-and-prospects
#7
REVIEW
Yujuan Li, Fangxue Xu, Mengmeng Zheng, Xiaozhi Xi, Xiaowei Cui, Chunchao Han
Maca polysaccharides, some of the major bioactive substances in Lepidium meyenii (Walp.) (Maca), have various biological properties, including anti-oxidant, anti-fatigue, anti-tumor, and immunomodulatory effects, as well as hepatoprotective activity and regulation function. Although many therapeutics depend on multiple structures of maca polysaccharides in addition to providing sufficient foundations for maca polysaccharide products in industrial applications, the relationships between the pharmacological effects and structures have not been established...
January 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29313251/unintentional-and-sequential-lead-exposure-from-a-ceramic-mug-and-maca-lepidium-meyenii
#8
Kelly Johnson-Arbor, Kathy Vo, Flavia Wong, Ryszard Gajek
Although the incidence of lead poisoning has decreased in the USA over the last 30 years, human exposures to lead-containing products are still reported. We present a case of unintentional lead exposure from a store-bought ceramic mug and a nutritional supplement. A 32-year-old female was found to have a whole blood lead concentration of 44 μg/dL. Evaluation of her home, occupation, and hobbies initially did not identify a source of lead exposure. Further investigation revealed that the likely etiology of the exposure was lead leaching from a ceramic mug used by the patient to drink hot lemon water while she was pregnant...
January 8, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29288688/neuroprotective-activity-of-macamides-on-manganese-induced-mitochondrial-disruption-in-u-87-mg-glioblastoma-cells
#9
Kuljeet S Gugnani, Nguyen Vu, Alejandro N Rondón-Ortiz, Mark Böhlke, Timothy J Maher, Alejandro J Pino-Figueroa
Macamides are a distinct class of secondary metabolites, benzylamides of long chain fatty acids, which were isolated from the Peruvian plant Lepidium meyenii (Maca). As structural analogues of the endocannabinoid anandamide (AEA), they have demonstrated neuroprotective effects in vitro and in vivo. The purpose of this study was to demonstrate the neuroprotective activity of the macamides: N-(3-methoxybenzyl)oleamide (MAC 18:1), N-(3-methoxybenzyl)linoleamide (MAC 18:2) and N-(3-methoxybenzyl)linolenamide (MAC 18:3) in a neurotoxic environment caused by exposure of U-87 MG glioblastoma cells to manganese chloride (MnCl2 )...
February 1, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29237937/drug-induced-liver-injury-due-to-lepidium-meyenii-maca-medicinal-liquor
#10
An Xiao, Hai-Ying He, Qing Chen, Shi-Wu Ma
No abstract text is available yet for this article.
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29232875/optimization-of-ultrasound-assisted-extraction-hplc-and-uhplc-esi-q-tof-ms-ms-analysis-of-main-macamides-and-macaenes-from-maca-cultivars-of-lepidium-meyenii-walp
#11
Shu-Xiao Chen, Ke-Ke Li, Duoji Pubu, Si-Ping Jiang, Bin Chen, Li-Rong Chen, Zhen Yang, Chao Ma, Xiao-Jie Gong
Ultrasound-assisted extraction (UAE), using petroleum ether as the solvent, was systematically applied to extract main macamides and macaenes from Maca hypocotyls. Extraction yield was related with four variables, including ratio of solution to solid, extraction temperature, extraction time, and extraction power. On the basis of response surface methodology (RSM), the optimal conditions were determined to be the ratio of solution to solid as 10:1 (mL/g), the extraction temperature of 40 °C, the extraction time of 30 min, and the extraction power of 200 W...
December 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29160562/aqueous-extract-of-yellow-maca-lepidium-meyenii-improves-sperm-count-in-experimental-animals-but-response-depends-on-hypocotyl-size-ph-and-routes-of-administration
#12
L Sanchez-Salazar, G F Gonzales
Lepidium meyenii, a Peruvian plant growing over 4000 m.a.s.l., has effects on nutrition and fertility. The purpose of this study was to evaluate the sperm count in 105 male mice receiving boiled aqueous extract of yellow maca hypocotyls from different sizes, under different pH conditions and using two different routes of administration. Five mice per group were treated daily for 3 days with vehicle (oral and intraperitoneal) or maca aqueous extracts (5 mg/0.5 ml/day) belonging to the first, second, third and fourth categories, according to their hypocotyl size...
April 2018: Andrologia
https://www.readbyqxmd.com/read/29080819/isolation-purification-and-antioxidant-activity-of-polysaccharides-from-the-leaves-of-maca-lepidium-meyenii
#13
Kang Caicai, Hao Limin, Zhang Liming, Zheng Zhiqiang, Yang Yongwu
Two fractions of polysaccharides (MLP-1 and MLP-2) were extracted from the leaves of maca (Lepidium Meyenii Walp.) by water, and purified using DEAE-52 ion exchange resin and sephadex G-200 clumns chromatography. An investigation was carried out for their structural characterization and antioxidant activity in vitro. The results indicated that MLP-1 was mainly composed of ribose, rhamnose, arabinose, xylose, mannose, glucose and galactose, with the molar ratio of 0.12:0.32:1.50:0.32:1.03:1.00:0.93; the MLP-2 was a homopolysaccharide composed of glucose...
February 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29047156/cyclophosphamide-induced-male-subfertility-in-mice-an-assessment-of-the-potential-benefits-of-maca-supplement
#14
A Y Onaolapo, B P Oladipo, O J Onaolapo
Effects of Lepidium meyenii (Maca) on cyclophosphamide (CYP)-induced gonadal toxicity in male mice were investigated. Mice were assigned to six treatment groups: Vehicle control, CYP control, CYP plus oral Maca (500 or 1,000 mg/kg), and oral Maca (500 or 1,000 mg/kg). CYP was administered via the intraperitoneal route (days 1-2), while vehicle or Maca were administered daily for 28 days. On day 28, half of the animals in each group were either sacrificed or paired with age-matched females for fertility assessment...
April 2018: Andrologia
https://www.readbyqxmd.com/read/28876077/biomimetic-synthesis-of-macahydantoins-a-and-b-from-lepidium-meyenii-and-structure-revision-of-macahydantoin-b-as-a-class-of-thiohydantoin-with-a-4-methyl-hexahydropyrrolo-1-2-c-imidazole-skeleton
#15
Min Zhou, Hang-Ying Ma, Huan-Huan Xing, Ping Li, Gan-Peng Li, Hui-Chun Geng, Qiu-Fen Hu, Guang-Yu Yang
Phytochemical investigation on Lepidium meyenii led to the discovery of macahydantoin C (3), a new thiohydantoin with a 1,3-diazabicyclo[3.3.1]nonane core, the spectral properties of which indicate a potential structural misassignment of its previously reported analogue, macahydantoin B (2a). To probe this hypothesis, a concise, scalable, and biomimetic synthesis of the originally proposed 2a and its revised structure (2b) was efficiently accomplished using the modified Edman degradation as the key step from commercially available materials in 65% (three steps) and 52% (three steps) overall yields, respectively...
September 6, 2017: Organic Letters
https://www.readbyqxmd.com/read/28846044/red-maca-lepidium-meyenii-a-plant-from-the-peruvian-highlands-promotes-skin-wound-healing-at-sea-level-and-at-high-altitude-in-adult-male-mice
#16
Denisse Nuñez, Paola Olavegoya, Gustavo F Gonzales, Cynthia Gonzales-Castañeda
Nuñez, Denisse, Paola Olavegoya, Gustavo F. Gonzales, and Cynthia Gonzales-Castañeda. Red maca (Lepidium meyenii), a plant from the Peruvian highlands, promotes skin wound healing at sea level and at high altitude in adult male mice. High Alt Med Biol 18:373-383, 2017.-Wound healing consists of three simultaneous phases: inflammation, proliferation, and remodeling. Previous studies suggest that there is a delay in the healing process in high altitude, mainly due to alterations in the inflammatory phase. Maca (Lepidium meyenii) is a Peruvian plant with diverse biological properties, such as the ability to protect the skin from inflammatory lesions caused by ultraviolet radiation, as well as its antioxidant and immunomodulatory properties...
December 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28822987/effects-of-a-water-extract-of-lepidium-meyenii-root-in-different-models-of-persistent-pain-in-rats
#17
Barbara Tenci, Lorenzo Di Cesare Mannelli, Mario Maresca, Laura Micheli, Giuseppe Pieraccini, Nadia Mulinacci, Carla Ghelardini
Lepidium meyenii (Walp.), commonly called maca, is an Andean crop belonging to the Brassicaceae family. Maca hypocotils are habitually consumed as customary food as well as traditional remedies for pathological conditions such as infertility. Moreover, the characterization of maca extracts revealed the presence of compounds that are able to modulate the nervous system. Aimed to evaluate the efficacy of L. meyenii in persistent pain, the present study analyzed the effects of a commercial root extract from maca in different animal models reproducing the most common causes of chronic painful pathologies...
October 26, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28811221/is-the-hype-around-the-reproductive-health-claims-of-maca-lepidium-meyenii-walp-justified
#18
REVIEW
Shruti Beharry, Michael Heinrich
ETHNOPHARMACOLOGICAL RELEVANCE: Maca - Lepidium meyenii Walp. has been cultivated and used by Andean people for over 1300-2000 years in Peru as food and medicine. Starting in the late 1990's it has developed into an important herbal medicine in China and is now cultivated there widely, too AIM OF STUDY: This study aims to provide an insight into the emergence of maca on the global market as an alternative remedy to treat reproductive health related problems in both men and women and to critically assess these health claims...
January 30, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28635053/protective-effects-of-lepidium-meyenii-maca-aqueous-extract-and-lycopene-on-testosterone-propionate-induced-prostatic-hyperplasia-in-mice
#19
Ying Zou, Waleed Aboshora, Jing Li, Tiancun Xiao, Lianfu Zhang
The inhibitory effect of maca extractant, lycopene, and their combination was evaluated in benign prostatic hyperplasia (BPH) mice induced by testosterone propionate. Mice were divided into a saline group, solvent control group and testosterone propionate-induced BPH mice [BPH model group, solvent BPH model group, benzyl glucosinolate group (1.44 mg/kg), maca group (60 mg/kg), lycopene treated (15, 5, and 2.5 mg/kg), maca (30 mg/kg) combine lycopene treated (7.5, 2.5, and 1.25 mg/kg), and finasteride treated]...
August 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28577982/purification-characterization-and-biological-activities-of-a-polysaccharide-from-lepidium-meyenii-leaves
#20
Shufang Li, Limin Hao, Qiaozhen Kang, Yinxin Cui, Hui Jiang, Xin Liu, Jike Lu
The characteristics and biological activities of a novel polysaccharide from Lepidium meyenii leaves (LMLP) were investigated. LMLP was purified using DEAE-52 cellulose chromatography followed by SephadexG-100 chromatography. The average molecule weight of LMLP was 58.43kDa and it was composed of galactose, arabinose, rhamnose, glucose and mannose with a relative molar ratio of 5.51:4.05:1.15:0.77:0.01. Antioxidant activity results showed that LMLP presented an EC50 of 3.72mg/mL in scavenging 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical, and it also had reducing power (OD700nm being 0...
October 2017: International Journal of Biological Macromolecules
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