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https://www.readbyqxmd.com/read/28441797/breast-cancer-awareness-among-women-in-western-amazon-a-population-based-cross-sectional-study
#1
Marla Presa Raulino Schilling, Ilce Ferreira da Silva, Simone Perufo Opitz, Maria Fernanda de Sousa Oliveira Borges, Sergio Koifman, Koifman Rosalina Jorge
Background: A general lack of women`s awareness of breast cancer has been one of the barriers to screening and early presentation. Thus, the aim of this study was to evaluate levels of knowledge about risk factors, and early warning signs of breast cancer, and to determine factors associated with better levels of comprehension. Methods: A population-based cross-sectional study was carried out among 478 women over 40 years old, living in Rio Branco city, western Amazon. All were interviewed using the “Breast cancer knowledge, attitudes and practice scale”, developed by American Cancer Society...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28441772/structural-and-biochemical-properties-of-novel-self-cleaving-ribozymes
#2
REVIEW
Ki-Young Lee, Bong-Jin Lee
Fourteen well-defined ribozyme classes have been identified to date, among which nine are site-specific self-cleaving ribozymes. Very recently, small self-cleaving ribozymes have attracted renewed interest in their structure, biochemistry, and biological function since the discovery, during the last three years, of four novel ribozymes, termed twister, twister sister, pistol, and hatchet. In this review, we mainly address the structure, biochemistry, and catalytic mechanism of the novel ribozymes. They are characterized by distinct active site architectures and divergent, but similar, biochemical properties...
April 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28441771/hepatocyte-growth-factor-c-met-signaling-in-head-and-neck-cancer-and-implications-for-treatment
#3
REVIEW
Natalie J Rothenberger, Laura P Stabile
Aberrant signaling of the hepatocyte growth factor (HGF)/c-Met pathway has been identified as a promoter of tumorigenesis in several tumor types including head and neck squamous cell carcinoma (HNSCC). Despite a relatively low c-Met mutation frequency, overexpression of HGF and its receptor c-Met has been observed in more than 80% of HNSCC tumors, with preclinical and clinical studies linking overexpression with cellular proliferation, invasion, migration, and poor prognosis. c-Met is activated by HGF through a paracrine mechanism to promote cellular morphogenesis enabling cells to acquire mesenchymal phenotypes in part through the epithelial-mesenchymal transition, contributing to metastasis...
April 24, 2017: Cancers
https://www.readbyqxmd.com/read/28441755/role-of-rheb-in-regulating-differentiation-fate-of-mesenchymal-stem-cells-for-cartilage-and-bone-regeneration
#4
Sajjad Ashraf, In-Bo Han, Hansoo Park, Soo-Hong Lee
Advances in mesenchymal stem cells (MSCs) and cell replacement therapies are promising approaches to treat cartilage and bone defects since substantial differentiation capacities of MSCs match the demands of tissue regeneration. Our understanding of the dynamic process requiring indispensable differentiation of MSCs remains limited. Herein, we describe the role of RHEB (Ras homolog enriched in brain) regulating gene signature for differentiation of human adipose derived mesenchymal stem cells (ASCs) into chondrogenic, osteogenic, and adipogenic lineages...
April 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28441746/high-performance-prediction-of-human-estrogen-receptor-agonists-based-on-chemical-structures
#5
Yuki Asako, Yoshihiro Uesawa
Many agonists for the estrogen receptor are known to disrupt endocrine functioning. We have developed a computational model that predicts agonists for the estrogen receptor ligand-binding domain in an assay system. Our model was entered into the Tox21 Data Challenge 2014, a computational toxicology competition organized by the National Center for Advancing Translational Sciences. This competition aims to find high-performance predictive models for various adverse-outcome pathways, including the estrogen receptor...
April 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28441741/peptides-peptidomimetics-and-polypeptides-from-marine-sources-a-wealth-of-natural-sources-for-pharmaceutical-applications
#6
Rushikesh Sable, Pravin Parajuli, Seetharama Jois
Nature provides a variety of peptides that are expressed in most living species. Evolutionary pressure and natural selection have created and optimized these peptides to bind to receptors with high affinity. Hence, natural resources provide an abundant chemical space to be explored in peptide-based drug discovery. Marine peptides can be extracted by simple solvent extraction techniques. The advancement of analytical techniques has made it possible to obtain pure peptides from natural resources. Extracted peptides have been evaluated as possible therapeutic agents for a wide range of diseases, including antibacterial, antifungal, antidiabetic and anticancer activity as well as cardiovascular and neurotoxin activity...
April 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28441713/accelerating-advances-in-science-engineering-and-medicine-through-nanoscience-and-nanotechnology
#7
Warren C W Chan, Ali Khademhosseini, Helmuth Möhwald, Wolfgang J Parak, Jeff F Miller, Aydogan Ozcan, Paul S Weiss
No abstract text is available yet for this article.
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28441712/virus-based-devices-prospects-for-allopoiesis
#8
Bogdan Dragnea
The assembly line is a commonly invoked example of allopoiesis, the process whereby a system produces a different system than itself. In this sense, virus production in plants is an instance of bio-enabled bottom-up allopoiesis because the plant host can be regarded as a programmable assembly line for the virus. Reprogramming this assembly line and integrating it into a larger lineup of chemical manipulations has seen a flurry of activity recently, with more sophisticated systems emerging every year. The field of virus nanomaterials now has several subdisciplines that focus on virus shells as assemblers, scaffolds for molecular circuitry, chemical reactors, magnetic and photonic beacons, and therapeutic carriers...
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28441682/chondrosarcoma-of-the-osseous-spine-an-analysis-of-epidemiology-patient-outcomes-and-prognostic-factors-using-the-seer-registry-from-1973-to-2012
#9
Armin Arshi, Justin Sharim, Don Y Park, Howard Y Park, Nicholas M Bernthal, Hamed Yazdanshenas, Arya N Shamie
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To determine the epidemiology and prognostic indicators in patients with chondrosarcoma of the osseous spine. SUMMARY OF BACKGROUND DATA: Chondrosarcoma of the spine is rare, with limited data on its epidemiology, clinicopathologic features, and treatment outcomes. Therapy centers on complete en bloc resection with radiotherapy reserved for subtotal resection or advanced disease. METHODS: The Surveillance, Epidemiology, and End Results Registry was queried for patients with chondrosarcoma of the osseous spine from 1973 to 2012...
May 1, 2017: Spine
https://www.readbyqxmd.com/read/28441673/gateways-to-the-laboratory-how-an-md-phd-program-increased-the-number-of-minority-physician-scientists
#10
Ruth Gotian, Jemella C Raymore, Shauna-Kay Rhooms, Laura Liberman, Olaf S Andersen
Traditional underrepresented minority (URM) groups (African Americans, Hispanic Americans, Native Americans) remain underrepresented among physician-scientists. To address the dearth of URM physician-scientists, in 1993 the Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program developed a pipeline program, Gateways to the Laboratory (Gateways), which focuses on increasing the breadth and depth of the URM physician-scientist pipeline by offering an all-encompassing summer research training program which mirrors the life of a physician-scientist...
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28441641/low-volume-contrast-ct-angiography-via-pulmonary-artery-injection-for-measurement-of-aortic-annulus-in-patients-undergoing-transcatheter-aortic-valve-replacement
#11
Vien T Truong, Joseph Choo, Luke McCoy, Adam Mussman, Stephanie Ambach, Dean Kereiakes, Ian Sarembock, Wojciech Mazur
OBJECTIVES: To investigate the feasibility and image quality of low-dose contrast computed tomography (CT) angiography with pulmonary artery (PA) protocol. BACKGROUND: Aortic stenosis is the most common valvular heart disease and transcatheter aortic valve replacement (TAVR) has evolved as an alternative method for surgical valve replacement in intermediate-risk and high-risk surgical patients. CT is essential for measurement of aortic annulus prior to TAVR. METHODS: Twenty patients underwent a low-dose contrast study with PA protocol and 20 patients underwent a traditional-dose study (traditional protocol)...
May 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28441639/antecubital-fossa-venous-access-for-right-heart-catheterization
#12
Omar Waheed, Abhinav Sharma, Maninder Singh, Edo Kaluski
With the advance of radial access and ulnar access there has been an increased interest in performing right heart catheterization (RHC) and right-heart based procedures via antecubital venous access. Our purpose is to describe the venous anatomy of the upper extremities, technique, equipment, and cost for employing this approach. Reported also is the international experience based on publications assessing procedural success, complications, fluoroscopy time and radiation dose, access-site compression time, and time to ambulation...
May 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28441633/a-health-intervention-or-a-kitchen-appliance-household-costs-and-benefits-of-a-cleaner-burning-biomass-fuelled-cookstove-in-malawi
#13
Katie Cundale, Ranjeeta Thomas, Jullita Kenala Malava, Deborah Havens, Kevin Mortimer, Lesong Conteh
Pneumonia is the leading cause of mortality for children under five years in sub-Saharan Africa. Household air pollution has been found to increase risk of pneumonia, especially due to exposure from dirty burning biomass fuels. It has been suggested that advanced stoves, which burn fuel more efficiently and reduce smoke emissions, may help to reduce household air pollution in poor, rural settings. This qualitative study aims to provide an insight into the household costs and perceived benefits from use of the stove in Malawi...
April 13, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28441599/transport-and-attenuation-of-salmonella-enterica-fecal-indicator-bacteria-and-a-poultry-litter-marker-gene-are-correlated-in-soil-columns
#14
Sirisha Mantha, Angela Anderson, Saraswati Poudel Acharya, Valerie J Harwood, Jennifer Weidhaas
Millions of tons of fecal-contaminated poultry litter are applied to U.S. agricultural fields annually. Precipitation and irrigation facilitate transport of fecal-derived pathogens and fecal indicator bacteria (FIB) to groundwater. The goal of this study was to compare transport of pathogens, FIB, and a microbial source tracking marker gene for poultry litter (LA35) in a simulated soil-to-groundwater system. Nine laboratory soil columns containing four different soil types were used to evaluate microbial transport to groundwater via infiltration...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28441587/epidermoid-cyst-of-the-spleen-a-case-report
#15
Sharmilee Vuyyuru, Bilal Kharbutli
INTRODUCTION: Splenic tumors are rare and are either primary or secondary, benign or malignant. Most have none to minimal symptomatology and are found incidentally. Splenic cysts can be infectious, congenital, or traumatic. Epidermoid cysts and parasitic cysts are examples of primary cysts and usually have a classic presentation on imaging. Despite advanced imaging modalities and patient's clinical presentation, it can be difficult to diagnose an epidermoid cyst without histological examination...
April 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28441534/managing-the-plant-microbiome-for-biocontrol-fungi-examples-from-hypocreales
#16
REVIEW
Ryan M Kepler, Jude E Maul, Stephen A Rehner
Feeding an increasing global population requires continued improvements in agricultural efficiency and productivity. Meeting estimated future production levels requires the adoption of practices that increase output without environmental degradation associated with external inputs to supplement nutrition or control pests. Enriching the community of microbes associated with plants in agricultural systems for those providing ecosystem services such as pest control is one possible component towards achieving sustainable productivity increases...
April 22, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/28441484/fully-quantum-description-of-the-zundel-ion-combining-variational-quantum-monte-carlo-with-path-integral-langevin-dynamics
#17
Félix Mouhat, Sandro Sorella, Rodolphe Vuilleumier, Antonino Marco Saitta, Michele Casula
We introduce a novel approach for a fully quantum description of coupled electron-ion systems from first principles. It combines the variational quantum Monte Carlo solution of the electronic part with the path integral formalism for the quantum nuclear dynamics. On the one hand, the path integral molecular dynamics includes nuclear quantum effects by adding a set of fictitious classical particles (beads) aimed at reproducing nuclear quantum fluctuations via a harmonic kinetic term. On the other hand, variational quantum Monte Carlo can provide Born-Oppenheimer potential energy surfaces with a precision comparable to the most advanced post Hartree-Fock approaches, and with a favorable scaling with the system size...
April 25, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28441481/best-practices-of-computer-aided-drug-discovery-cadd-lessons-learned-from-the-development-of-a-preclinical-candidate-for-prostate-cancer-with-a-new-mechanism-of-action
#18
Fuqiang Ban, Kush Dalal, Huifang Li, Eric LeBlanc, Paul S Rennie, Artem Cherkasov
Small-molecule drug design is a complex and iterative decision-making process relying on pre-existing knowledge and driven by experimental data. Low molecular weight chemicals represent an attractive therapeutic option as they are readily accessible to organic synthesis and can easily be characterized.1 Their potency, as well as pharmacokinetic and pharmacodynamic properties can be systematically and rationally investigated, and ultimately optimized via expert science behind medicinal chemistry and methods of computer-aided drug design (CADD)...
April 25, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28441463/rapidsnps-a-new-computational-pipeline-for-rapidly-identifying-key-genetic-variants-reveals-previously-unidentified-snps-that-are-significantly-associated-with-individual-platelet-responses
#19
Bajuna Rashid Salehe, Chris Ian Jones, Giuseppe Di Fatta, Liam James McGuffin
Advances in omics technologies have led to the discovery of genetic markers, or single nucleotide polymorphisms (SNPs), that are associated with particular diseases or complex traits. Although there have been significant improvements in the approaches used to analyse associations of SNPs with disease, further optimised and rapid techniques are needed to keep up with the rate of SNP discovery, which has exacerbated the 'missing heritability' problem. Here, we have devised a novel, integrated, heuristic-based, hybrid analytical computational pipeline, for rapidly detecting novel or key genetic variants that are associated with diseases or complex traits...
2017: PloS One
https://www.readbyqxmd.com/read/28441410/creating-and-parameterizing-patient-specific-deep-brain-stimulation-pathway-activation-models-using-the-hyperdirect-pathway-as-an-example
#20
Kabilar Gunalan, Ashutosh Chaturvedi, Bryan Howell, Yuval Duchin, Scott F Lempka, Remi Patriat, Guillermo Sapiro, Noam Harel, Cameron C McIntyre
BACKGROUND: Deep brain stimulation (DBS) is an established clinical therapy and computational models have played an important role in advancing the technology. Patient-specific DBS models are now common tools in both academic and industrial research, as well as clinical software systems. However, the exact methodology for creating patient-specific DBS models can vary substantially and important technical details are often missing from published reports. OBJECTIVE: Provide a detailed description of the assembly workflow and parameterization of a patient-specific DBS pathway-activation model (PAM) and predict the response of the hyperdirect pathway to clinical stimulation...
2017: PloS One
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