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https://www.readbyqxmd.com/read/29115871/attendance-at-fragile-x-specialty-clinics-facilitators-and-barriers
#1
Sharon A Kidd, Melissa Raspa, Renée Clark, Holly Usrey-Roos, Anne C Wheeler, Jessica A Liu, Amanda Wylie, Stephanie L Sherman
The objectives were to describe the demographic characteristics of children with Fragile X syndrome (FXS) and to determine predictors of attendance at Fragile X (FX) clinics. Findings from the Community Support Network (CSN) and Our Fragile X World (OFXW) samples showed that children who attended FX Clinics were mostly male, high-school aged or younger, and white, non-Hispanic. Using logistic regression models, awareness about FX Clinic services, guardian education, and income (CSN), and child age, family income, and total number of co-occurring conditions (OFXW) were predictors of clinic attendance...
November 2017: American Journal on Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29094788/when-global-rule-reversal-meets-local-task-switching-the-neural-mechanisms-of-coordinated-behavioral-adaptation-to-instructed-multi-level-demand-changes
#2
Yiquan Shi, Uta Wolfensteller, Torsten Schubert, Hannes Ruge
Cognitive flexibility is essential to cope with changing task demands and often it is necessary to adapt to combined changes in a coordinated manner. The present fMRI study examined how the brain implements such multi-level adaptation processes. Specifically, on a "local," hierarchically lower level, switching between two tasks was required across trials while the rules of each task remained unchanged for blocks of trials. On a "global" level regarding blocks of twelve trials, the task rules could reverse or remain the same...
November 2, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29053748/treatment-with-the-nr4a1-agonist-cytosporone-b-controls-influenza-virus-infection-and-improves-pulmonary-function-in-infected-mice
#3
Benoit Egarnes, Marie-Renée Blanchet, Jean Gosselin
The transcription factor NR4A1 has emerged as a pivotal regulator of the inflammatory response and immune homeostasis. Although contribution of NR4A1 in the innate immune response has been demonstrated, its role in host defense against viral infection remains to be investigated. In the present study, we show that administration of cytosporone B (Csn-B), a specific agonist of NR4A1, to mice infected with influenza virus (IAV) reduces lung viral loads and improves pulmonary function. Our results demonstrate that administration of Csn-B to naive mice leads to a modest production of type 1 IFN...
2017: PloS One
https://www.readbyqxmd.com/read/28966286/transcatheter-aortic-valve-implantation-improves-cardiac-sympathetic-nerve-activity-on-123-i-metaiodobenzylguanidine-myocardial-scintigraphy-in-severe-aortic-valve-stenosis
#4
Mitsuo Sobajima, Hiroshi Ueno, Hiroshi Onoda, Hiroyuki Kuwahara, Shuhei Tanaka, Ryuichi Ushijima, Nobuyuki Fukuda, Shigeki Yokoyama, Saori Nagura, Toshio Doi, Akio Yamashita, Kazuaki Fukahara, Hisakatsu Ito, Koichiro Kinugawa
BACKGROUND: There is a consensus that overactivation of the cardiac sympathetic nervous system (CSN) proportionately increases the severity of heart failure and is accompanied by worse prognosis. Because it is unknown whether patients with aortic valve stenosis (AS) have similar CSN activation, we investigated the effect of transcatheter aortic valve implantation (TAVI).Methods and Results:We enrolled 31 consecutive patients with AS treated by TAVI. (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy was performed at baseline and at 2 weeks after TAVI...
September 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28960798/a-peroxisome-inspired-chemiluminescent-silica-nanodevice-for-the-intracellular-detection-of-biomarkers-and-its-application-to-insulin-sensitizer-screening
#5
Xu Jie, Haimei Yang, Min Wang, Yue Zhang, Weili Wei, Zhining Xia
The profiling of oxidase-catalyzed biomarkers is an essential procedure for the diagnosis and precise treatment of metabolic diseases. Inspired by the metabolism of H2 O2 in peroxisomes, a novel chemiluminescent silica nanodevice (CSN) was designed for the sensitive and selective sensing of intracellular oxidase-catalyzed biomarkers. Oxidases catalyzed the oxidation of biomarkers followed by the production of H2 O2 , and then the generated H2 O2 was employed to trigger chemiluminescence of the CSN. Utilizing this nanodevice, we not only accurately quantified intracellular glucose but also developed its further application for facile insulin sensitizer screening...
September 28, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28942925/deconstruction-of-corticospinal-circuits-for-goal-directed-motor-skills
#6
Xuhua Wang, Yuanyuan Liu, Xinjian Li, Zicong Zhang, Hengfu Yang, Yu Zhang, Philip R Williams, Noaf S A Alwahab, Kush Kapur, Bin Yu, Yiming Zhang, Mengying Chen, Haixia Ding, Charles R Gerfen, Kuan Hong Wang, Zhigang He
Corticospinal neurons (CSNs) represent the direct cortical outputs to the spinal cord and play important roles in motor control across different species. However, their organizational principle remains unclear. By using a retrograde labeling system, we defined the requirement of CSNs in the execution of a skilled forelimb food-pellet retrieval task in mice. In vivo imaging of CSN activity during performance revealed the sequential activation of topographically ordered functional ensembles with moderate local mixing...
October 5, 2017: Cell
https://www.readbyqxmd.com/read/28923850/increasing-the-unneddylated-cullin1-portion-rescues-the-csn-phenotypes-by-stabilizing-adaptor-modules-to-drive-scf-assembly
#7
Qingqing Liu, Yike Zhou, Ruiqi Tang, Xuehong Wang, Qiwen Hu, Ying Wang, Qun He
The dynamic SCF (Skp1-cullin1-F-box protein) assembly is controlled by cycles of cullin neddylation/deneddylation based on the deneddylation activity of the COP9 signalosome (CSN) and global sequestration of cullins by CAND1. However, acceptance of this prediction was hampered by the results of recent studies, and the regulatory mechanism and key players remain to be identified. We found that maintaining a proper Cul1(Nedd8)/Cul1 ratio is crucial to ensure SCF functions. Reducing the high Cul1(Nedd8)/Cul1 ratios in csn mutants through ectopic expression of the nonneddylatable Cul1(K722R) proteins or introducing the endogenous cul1(K722R) point mutation significantly rescues their defective phenotypes...
December 1, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28902143/joint-resource-optimization-for-cognitive-sensor-networks-with-swipt-enabled-relay
#8
Weidang Lu, Yuanrong Lin, Hong Peng, Tian Nan, Xin Liu
Energy-constrained wireless networks, such as wireless sensor networks (WSNs), are usually powered by fixed energy supplies (e.g., batteries), which limits the operation time of networks. Simultaneous wireless information and power transfer (SWIPT) is a promising technique to prolong the lifetime of energy-constrained wireless networks. This paper investigates the performance of an underlay cognitive sensor network (CSN) with SWIPT-enabled relay node. In the CSN, the amplify-and-forward (AF) relay sensor node harvests energy from the ambient radio-frequency (RF) signals using power splitting-based relaying (PSR) protocol...
September 13, 2017: Sensors
https://www.readbyqxmd.com/read/28891468/epidermal-growth-factor-receptor-neddylation-is-regulated-by-a-desmosomal-cop9-constitutive-photomorphogenesis-9-signalosome-complex
#9
Nicole Ann Najor, Gillian Nicole Fitz, Jennifer Leigh Koetsier, Lisa Marie Godsel, Lauren Veronica Albrecht, Robert Harmon, Kathleen Janee Green
Cell junctions are scaffolds that integrate mechanical and chemical signaling. We previously showed that a desmosomal cadherin promotes keratinocyte differentiation in an adhesion-independent manner by dampening Epidermal Growth Factor Receptor (EGFR) activity. Here we identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation...
September 11, 2017: ELife
https://www.readbyqxmd.com/read/28861005/murine-myocardial-transcriptome-analysis-reveals-a-critical-role-of-cops8-in-the-gene-expression-of-cullin-ring-ligase-substrate-receptors-and-redox-and-vesicle-trafficking-pathways
#10
Ammara Abdullah, Kathleen M Eyster, Travis Bjordahl, Peng Xiao, Erliang Zeng, Xuejun Wang
Background: The COP9 signalosome (CSN) consisting of 8 unique protein subunits (COPS1 through COPS8) serves as the cullin deneddylase, regulating the catalytic dynamics of cullin RING ligases (CRLs), the largest family of ubiquitin ligases Background: The COP9 signalosome (CSN) consisting of 8 unique protein subunits (COPS1 through COPS8) serves as the cullin deneddylase, regulating the catalytic dynamics of cullin RING ligases (CRLs), the largest family of ubiquitin ligases. Supported primarily by the decrease of substrate receptor (SR) proteins of CRLs in cells deficient of a CSN subunit, CSN-mediated cullin deneddylation is believed to prevent autoubiquitination and self-destruction of the SR in active CRLs...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28842025/an-integrated-automatic-system-to-evaluate-u-and-th-dynamic-lixiviation-from-solid-matrices-and-to-extract-pre-concentrate-leached-analytes-previous-icp-ms-detection
#11
Melisa Rodas Ceballos, Rafael García-Tenorio, José Manuel Estela, Víctor Cerdà, Laura Ferrer
Leached fractions of U and Th from different environmental solid matrices were evaluated by an automatic system enabling the on-line lixiviation and extraction/pre-concentration of these two elements previous ICP-MS detection. UTEVA resin was used as selective extraction material. Ten leached fraction, using artificial rainwater (pH 5.4) as leaching agent, and a residual fraction were analyzed for each sample, allowing the study of behavior of U and Th in dynamic lixiviation conditions. Multivariate techniques have been employed for the efficient optimization of the independent variables that affect the lixiviation process...
December 1, 2017: Talanta
https://www.readbyqxmd.com/read/28748859/recommendations-for-electroencephalography-monitoring-in-neurocritical-care-units
#12
(no author information available yet)
No abstract text is available yet for this article.
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28745441/clinical-staff-nurse-leadership-identifying-gaps-in-competency-development
#13
Sherron Franks-Meeks
BACKGROUND: To date, there has been no development of a complete, applicable inventory of clinical staff nurse (CSN) leadership role competencies through a valid and reliable methodology. Further, the CSN has not been invited to engage in the identification, definition, or development of their own leadership competencies. OBJECTIVE: Compare existing leadership competencies to identify and highlight gaps in clinical staff nurse leadership role competency development and validation...
July 26, 2017: Nursing Forum
https://www.readbyqxmd.com/read/28744713/genome-wide-analysis-of-gene-expression-profiling-revealed-that-cop9-signalosome-is-essential-for-correct-expression-of-fe-homeostasis-genes-in-arabidopsis
#14
Seckin Eroglu, Emre Aksoy
In plant cells, either excess or insufficient iron (Fe) concentration triggers stress responses, therefore it is strictly controlled. Proteasome-mediated degradation through ubiquitination of Fe homeostasis proteins has just become the focus of research in recent years. Deactivating ubiquitin ligases, COP9 signalosome has a central importance in the translational control of various stress responses. The aim of the study was to investigate COP9 signalosome in Fe deficiency response of Strategy I plants. In silico analysis of a set of Fe-deficiency-responsive genes was conducted against the transcriptome of Arabidopsis csn mutant lines using Genevestigator software...
October 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28740186/carotid-sinus-nerve-electrical-stimulation-in-conscious-rats-attenuates-systemic-inflammation-via-chemoreceptor-activation
#15
Fernanda Machado Santos-Almeida, Gean Domingos-Souza, César A Meschiari, Laura Campos Fávaro, Christiane Becari, Jaci A Castania, Alexandre Lopes, Thiago M Cunha, Davi J A Moraes, Fernando Q Cunha, Luis Ulloa, Alexandre Kanashiro, Geisa C S V Tezini, Helio C Salgado
Recent studies demonstrated a critical functional connection between the autonomic (sympathetic and parasympathetic) nervous and the immune systems. The carotid sinus nerve (CSN) conveys electrical signals from the chemoreceptors of the carotid bifurcation to the central nervous system where the stimuli are processed to activate sympathetic and parasympathetic efferent signals. Here, we reported that chemoreflex activation via electrical CSN stimulation, in conscious rats, controls the innate immune response to lipopolysaccharide attenuating the plasma levels of inflammatory cytokines such as tumor necrosis factor (TNF), interleukin 1β (IL-1β) and interleukin 6 (IL-6)...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28682262/cell-like-spiking-neural-p-systems-with-request-rules
#16
Linqiang Pan, Tingfang Wu, Yansen Su, Athanasios V Vasilakos
Cell-like spiking neural (cSN) P systems are a class of distributed and parallel computation models inspired by both the way in which neurons process information and communicate to each other by means of spikes and the compartmentalized structures of living cells. cSN P systems have been proved to be Turing universal if more spikes can be produced by consuming some spikes or spikes can be replicated. In this paper, in order to answer the open problem whether this functioning of producing more spikes and replicating spikes can be avoided by using some strategy without the loss of computation power, we introduce cSN P systems with request rules, which have classical spiking rules and forgetting rules, and also request rules in the skin membrane...
September 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28623958/knockdown-of-subunit-3-of-the-cop9-signalosome-inhibits-c2c12-myoblast-differentiation-via-nf-kappab-signaling-pathway
#17
Mariam A Ba, Jeffrey Surina, Cherie A Singer, Maria L Valencik
BACKGROUND: The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex. CSN3 binds to the striated muscle-specific β1D integrin tail, and its subcellular localization is altered in differentiated skeletal muscle cells. However, the role of CSN3 in skeletal muscle differentiation is unknown. The main goal of this study was to identify whether CSN3 participates in myoblast differentiation and the signalling mechanisms involved using C2C12 cells as a skeletal muscle cell model...
June 17, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28550524/cop9-signalosome-subunit-pfcsne-regulates-secondary-metabolism-and-conidial-formation-in-pestalotiopsis-fici
#18
Yanjing Zheng, Xiuna Wang, Xiaoling Zhang, Wei Li, Gang Liu, Shihua Wang, Xiufeng Yan, Huixi Zou, Wen-Bing Yin
The COP9 signalosome (CSN) is a highly conserved multiprotein complex in all eukaryotes and involved in regulation of organism development. In filamentous fungi, several lines of evidence indicate that fungal development and secondary metabolism (SM) are mediated by the fifth subunit of CSN, called CsnE. Here we uncover a connection with CsnE and conidial formation as well as SM regulation in the plant endophytic fungus Pestalotiopsis fici. A homology search of the P. fici genome with CsnE, involved in sexual development and SM in Aspergillus nidulans, identified PfCsnE...
May 25, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28539160/phosphorylation-of-p53-at-threonine-155-is-required-for-jab1-mediated-nuclear-export-of-p53
#19
Eun-Woo Lee, Wonkyung Oh, Hosung Paul Song, Won Kon Kim
The Jun activation-domain binding protein 1 (Jab1) induces p53 nuclear export and cytoplasmic degradation, but the underlying mechanism is poorly understood. Here, we show that phosphorylation at the threonine 155 residue is essential for Jab1-mediated p53 nuclear export. Jab1 stimulated phosphorylation of p53 at T155 was inhibited by curcumin, an inhibitor of COP9 signalosome (CSN)-associated kinases. The T155E mutant, which mimics phosphorylated p53, exhibited spontaneous cytoplasmic localization in the absence of Jab1...
July 2017: BMB Reports
https://www.readbyqxmd.com/read/28443828/controlled-synthesis-of-mno2-nanosheets-vertically-covered-feco2o4-nanoflakes-as-binder-free-electrode-for-high-power-and-durable-asymmetric-supercapacitor
#20
Hongyan Gao, Junjie Xiang, Yan Cao
We developed a simple and controlled method to synthesize FeCo2O4@MnO2 core-sheath nanoarchitecture (CSN) grown on the Ni foam. Ultrathin FeCo2O4 nanoflakes with an average thickness of 10 nm served as the scaffold to deposit MnO2 nanosheets. The MnO2 nanosheets were able to vertically grow on FeCo2O4 nanoflakes to form a sheath via a hydrothermal reaction. The nanocomposites' thickness can be tailored from 80 nm to 550 nm by changing the reaction times. Electrochemical measurements demonstrated that FeCo2O4@MnO2 CSN with an optimal thickness about 400 nm achieved an areal capacitance of 3...
April 26, 2017: Nanotechnology
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