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https://www.readbyqxmd.com/read/28748859/recommendations-for-electroencephalography-monitoring-in-neurocritical-care-units
#1
(no author information available yet)
No abstract text is available yet for this article.
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28745441/clinical-staff-nurse-leadership-identifying-gaps-in-competency-development
#2
Sherron Franks-Meeks
BACKGROUND: To date, there has been no development of a complete, applicable inventory of clinical staff nurse (CSN) leadership role competencies through a valid and reliable methodology. Further, the CSN has not been invited to engage in the identification, definition, or development of their own leadership competencies. OBJECTIVE: Compare existing leadership competencies to identify and highlight gaps in clinical staff nurse leadership role competency development and validation...
July 26, 2017: Nursing Forum
https://www.readbyqxmd.com/read/28744713/genome-wide-analysis-of-gene-expression-profiling-revealed-that-cop9-signalosome-is-essential-for-correct-expression-of-fe-homeostasis-genes-in-arabidopsis
#3
Seckin Eroglu, Emre Aksoy
In plant cells, either excess or insufficient iron (Fe) concentration triggers stress responses, therefore it is strictly controlled. Proteasome-mediated degradation through ubiquitination of Fe homeostasis proteins has just become the focus of research in recent years. Deactivating ubiquitin ligases, COP9 signalosome has a central importance in the translational control of various stress responses. The aim of the study was to investigate COP9 signalosome in Fe deficiency response of Strategy I plants. In silico analysis of a set of Fe-deficiency-responsive genes was conducted against the transcriptome of Arabidopsis csn mutant lines using Genevestigator software...
July 25, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28740186/carotid-sinus-nerve-electrical-stimulation-in-conscious-rats-attenuates-systemic-inflammation-via-chemoreceptor-activation
#4
Fernanda Machado Santos-Almeida, Gean Domingos-Souza, César A Meschiari, Laura Campos Fávaro, Christiane Becari, Jaci A Castania, Alexandre Lopes, Thiago M Cunha, Davi J A Moraes, Fernando Q Cunha, Luis Ulloa, Alexandre Kanashiro, Geisa C S V Tezini, Helio C Salgado
Recent studies demonstrated a critical functional connection between the autonomic (sympathetic and parasympathetic) nervous and the immune systems. The carotid sinus nerve (CSN) conveys electrical signals from the chemoreceptors of the carotid bifurcation to the central nervous system where the stimuli are processed to activate sympathetic and parasympathetic efferent signals. Here, we reported that chemoreflex activation via electrical CSN stimulation, in conscious rats, controls the innate immune response to lipopolysaccharide attenuating the plasma levels of inflammatory cytokines such as tumor necrosis factor (TNF), interleukin 1β (IL-1β) and interleukin 6 (IL-6)...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28682262/cell-like-spiking-neural-p-systems-with-request-rules
#5
Linqiang Pan, Tingfang Wu, Yansen Su, Athanasios V Vasilakos
Cell-like spiking neural P systems (in short, cSN P systems) are a class of distributed and parallel computation models inspired by both the way in which neurons process information and communicate to each other by means of spikes and the compartmentalized structures of living cells. cSNP systems have been proved to be Turing universal if more spikes can be produced by consuming some spikes or spikes can be replicated. In this work, in order to answer the open problem whether this functioning of producing more spikes and replicating spikes can be avoided by using some strategy without the loss of computation power, we introduce cSN P systems with request rules, which have classical spiking rules and forgetting rules, and also request rules in the skin membrane...
July 3, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28623958/knockdown-of-subunit-3-of-the-cop9-signalosome-inhibits-c2c12-myoblast-differentiation-via-nf-kappab-signaling-pathway
#6
Mariam A Ba, Jeffrey Surina, Cherie A Singer, Maria L Valencik
BACKGROUND: The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex. CSN3 binds to the striated muscle-specific β1D integrin tail, and its subcellular localization is altered in differentiated skeletal muscle cells. However, the role of CSN3 in skeletal muscle differentiation is unknown. The main goal of this study was to identify whether CSN3 participates in myoblast differentiation and the signalling mechanisms involved using C2C12 cells as a skeletal muscle cell model...
June 17, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28550524/cop9-signalosome-subunit-pfcsne-regulates-secondary-metabolism-and-conidial-formation-in-pestalotiopsis-fici
#7
Yanjing Zheng, Xiuna Wang, Xiaoling Zhang, Wei Li, Gang Liu, Shihua Wang, Xiufeng Yan, Huixi Zou, Wen-Bing Yin
The COP9 signalosome (CSN) is a highly conserved multiprotein complex in all eukaryotes and involved in regulation of organism development. In filamentous fungi, several lines of evidence indicate that fungal development and secondary metabolism (SM) are mediated by the fifth subunit of CSN, called CsnE. Here we uncover a connection with CsnE and conidial formation as well as SM regulation in the plant endophytic fungus Pestalotiopsis fici. A homology search of the P. fici genome with CsnE, involved in sexual development and SM in Aspergillus nidulans, identified PfCsnE...
May 25, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28539160/phosphorylation-of-p53-at-threonine-155-is-required-for-jab1-mediated-nuclear-export-of-p53
#8
Eun-Woo Lee, Wonkyung Oh, Hosung Paul Song, Won Kon Kim
The Jun activation-domain binding protein 1 (Jab1) induces p53 nuclear export and cytoplasmic degradation. However, the underlying mechanism is not clearly addressed. Here, we identify that phosphorylation at threonine 155 residue is indispensable for Jab1-mediated p53 nuclear export. Jab1 stimulated phosphorylation of p53 at T155, which was inhibited by curcumin, an inhibitor of COP9 signalosome (CSN)-associated kinases. T155E mutant, which mimics phosphorylated p53, exhibited spontaneous cytoplasmic localization in the absence of Jab1...
May 25, 2017: BMB Reports
https://www.readbyqxmd.com/read/28443828/controlled-synthesis-of-mno2-nanosheets-vertically-covered-feco2o4-nanoflakes-as-binder-free-electrode-for-high-power-and-durable-asymmetric-supercapacitor
#9
Hongyan Gao, Junjie Xiang, Yan Cao
We developed a simple and controlled method to synthesize FeCo2O4@MnO2 core-sheath nanoarchitecture (CSN) grown on the Ni foam. Ultrathin FeCo2O4 nanoflakes with an average thickness of 10 nm served as the scaffold to deposit MnO2 nanosheets. The MnO2 nanosheets were able to vertically grow on FeCo2O4 nanoflakes to form a sheath via a hydrothermal reaction. The nanocomposites' thickness can be tailored from 80 nm to 550 nm by changing the reaction times. Electrochemical measurements demonstrated that FeCo2O4@MnO2 CSN with an optimal thickness about 400 nm achieved an areal capacitance of 3...
April 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28379117/an-evaluation-of-mass-absorption-cross-section-for-optical-carbon-analysis-on-teflon-filter-media
#10
Paige Presler-Jur, Prakash Doraiswamy, Oki Hammond, Joann Rice
Black carbon (BC) or elemental carbon (EC) is a by-product of incomplete fuel combustion, and contributes adversely to human health, visibility, and climate impacts. Previous studies have examined non-destructive techniques for particle light attenuation measurements on Teflon(®) filters to estimate BC. The incorporation of an inline Magee Scientific OT21 Transmissometer into the MTL AH-225 robotic weighing system provides the opportunity to perform optical transmission measurements on Teflon(®) filters at the same time as the gravimetric mass measurement...
April 5, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28378888/a-novel-electrophoretic-deposited-coordination-supramolecular-network-film-for-detecting-phosphate-and-biophosphate
#11
Tianshu Chu, Feng Zhang, Yi Wang, Yangyi Yang, Seik Weng Ng
A series of new lanthanide coordination supramolecular networks (CSNs) based on nalidixic acid (HNA) ligand were designed and synthesized. Their crystal structures were determined by single-crystal XRD techniques. Thin films of these compounds were first successfully deposited on indium tin oxide (ITO) glass through one-step electrophoretic deposition under mild conditions. The europium CSN film exhibits intense red emission and can act as a highly sensitive luminescent sensor for H2 PO4(-) anions and adenosine triphosphate (ATP) in aqueous solution...
April 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28377589/the-arabidopsis-cop9-signalosome-subunit-4-cns4-is-involved-in-adventitious-root-formation
#12
Daniel Ioan Pacurar, Monica Lacramioara Pacurar, Abdellah Lakehal, Andrea Mariana Pacurar, Alok Ranjan, Catherine Bellini
The COP9 signalosome (CSN) is an evolutionary conserved multiprotein complex that regulates many aspects of plant development by controlling the activity of CULLIN-RING E3 ubiquitin ligases (CRLs). CRLs ubiquitinate and target for proteasomal degradation a vast number of specific substrate proteins involved in many developmental and physiological processes, including light and hormone signaling and cell division. As a consequence of CSN pleiotropic function, complete loss of CSN activity results in seedling lethality...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28377317/dehydroascorbate-derivatized-chitosan-particles-for-targeting-antimalarial-agents-to-infected-erythrocytes
#13
Hasham Shafi, D V Siva Reddy, Tabassum Khan, Rajeev Ranjan, Ashish Srivastava, Suniti Vaishya, Tanuj Sharma, Mohammad Imran Siddiqui, Saman Habib, Amit Misra
The mammalian glucose transporter GLUT-1 and Plasmodium falciparum hexose transporter PfHT1 are overexpressed on human RBC infected with the parasite (iRBC), presumably for enhanced glucose uptake. Dehydroascorbic acid (DHA) competes out glucose in GLUT-1 binding. We prepared particles containing chloroquine phosphate using novel derivatives of chitosan (CSN). CSN was either pre-derivatized with DHA (PRE) or particles made of CSN were derivatized by surface-grafting DHA (POST). The optimized formulations were analyzed for size (170-200nm) drug content (about 40%) entrapment efficiency (50-57%), in vitro drug release (80% in 72h, Higuchi's model), hemolysis on exposure to whole blood or RBC at 5% hematocrit, cytotoxicity towards cultured HEK 293T (kidney) and HepG2 (hepatic) cells, targeting iRBC and in vitro efficacy against P...
April 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28371146/investigating-chitin-deacetylation-and-chitosan-hydrolysis-during-vegetative-growth-in-magnaporthe-oryzae
#14
Ivey A Geoghegan, Sarah J Gurr
Chitin deacetylation results in the formation of chitosan, a polymer of β1,4-linked glucosamine. Chitosan is known to have important functions in the cell walls of a number of fungal species, but its role during hyphal growth has not yet been investigated. In this study, we have characterized the role of chitin deacetylation during vegetative hyphal growth in the filamentous phytopathogen Magnaporthe oryzae. We found that chitosan localizes to the septa and lateral cell walls of vegetative hyphae and identified 2 chitin deacetylases expressed during vegetative growth-CDA1 and CDA4...
March 29, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28340738/-226-ra-dynamic-lixiviation-from-phosphogypsum-samples-by-an-automatic-flow-through-system-with-integrated-renewable-solid-phase-extraction
#15
Melisa Rodas Ceballos, Antoni Borràs, Rafael García-Tenorio, Rogelio Rodríguez, José Manuel Estela, Víctor Cerdà, Laura Ferrer
The release of (226)Ra from phosphogypsum (PG) was evaluated by developing a novel tool for fully automated (226)Ra lixiviation from PG integrating extraction/pre-concentration using a renewable sorbent format. Eight leached fractions (30mL each one) and a residual fraction were analyzed allowing the evaluation of dynamic lixiviation of (226)Ra. An automatic system allows this approach coupling a homemade cell with a (226)Ra extraction/pre-concentration method, which is carried out combining two procedures: Ra adsorption on MnO2 and its posterior co-precipitation with BaSO4...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340059/topic-modeling-of-smoking-and-cessation-related-posts-to-the-american-cancer-society-s-cancer-survivor-network-csn-implications-for-cessation-treatment-for-cancer-survivors-who-smoke
#16
J Lee Westmaas, Bennett McDonald, Ken Portier
Introduction: Smoking is a risk factor in at least 18 cancers, and approximately two-thirds of cancer survivors continue smoking following diagnosis. Text mining of survivors' online posts related to smoking and quitting could inform strategies to reduce smoking in this vulnerable population. Methods: We identified posts containing smoking/cessation-related keywords from the Cancer Survivors Network (CSN), an online cancer survivor community of 166,000 members and over 468,000 posts since inception...
March 15, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28321324/choosing-wisely-the-canadian-society-of-nephrology-s-list-of-5-items-physicians-and-patients-should-question
#17
Emilie Chan, Brenda Hemmelgarn, Scott Klarenbach, Braden Manns, Reem Mustafa, Gihad Nesrallah, Rory McQuillan
PURPOSE OF REVIEW: The purpose of this review is to contribute to the Choosing Wisely Canada campaign and develop a list of 5 items for nephrology health care professionals and patients to re-evaluate based on evidence that they are overused or misused. SOURCES OF INFORMATION: A working group was formed from the Canadian Society of Nephrology (CSN) Clinical Practice Guidelines Committee. This working group sequentially used a multistage Delphi method, a survey of CSN members, a modified Delphi process, and a comprehensive literature review to determine 10 candidate items representing potentially ineffective care in nephrology...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28300763/joint-resource-allocation-of-spectrum-sensing-and-energy-harvesting-in-an-energy-harvesting-based-cognitive-sensor-network
#18
Xin Liu, Weidang Lu, Liang Ye, Feng Li, Deyue Zou
The cognitive sensor (CS) can transmit data to the control center in the same spectrum that is licensed to the primary user (PU) when the absence of the PU is detected by spectrum sensing. However, the battery energy of the CS is limited due to its small size, deployment in atrocious environments and long-term working. In this paper, an energy-harvesting-based CS is described, which senses the PU together with collecting the radio frequency energy to supply data transmission. In order to improve the transmission performance of the CS, we have proposed the joint resource allocation of spectrum sensing and energy harvesting in the cases of a single energy-harvesting-based CS and an energy-harvesting-based cognitive sensor network (CSN), respectively...
March 16, 2017: Sensors
https://www.readbyqxmd.com/read/28278081/correlative-analysis-of-plasma-sn-38-levels-and-dpd-activity-with-outcomes-of-folfiri-regimen-for-metastatic-colorectal-cancer-with-ugt1a1-28-and-6-wild-type-and-its-implication-for-individualized-chemotherapy
#19
Xun Cai, Chuan Tian, Liwei Wang, Rongyuan Zhuang, Xiaowei Zhang, Yuanbiao Guo, Hongmin Lu, Hui Wang, Xiaoyu Li, Junwei Gao, Qi Li, Chungang Wang
It remains uncertain whether there is an correlation between clinical pharmacokinetic parameters and outcomes for metastatic colorectal cancer especially with UGT1A1 *28 and *6 wild type (*1/*1-*1/*1) for serious events associated with Irinotecan are largely excluded. This study retrospectively analyzed the relationship between Irinotecan metabolite levels and outcomes of UGT1A1 *1/*1-*1/*1 genotype arrangement. Blood samples (n = 244) were collected for analysis of plasma DPD activity (before first chemotherapy) and SN-38 levels (1...
March 4, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28245560/the-regulations-of-deubiquitinase-usp15-and-its-pathophysiological-mechanisms-in-diseases
#20
REVIEW
Chon-Kit Chou, Yu-Ting Chang, Michal Korinek, Yei-Tsung Chen, Ya-Ting Yang, Steve Leu, I-Ling Lin, Chin-Ju Tang, Chien-Chih Chiu
Deubiquitinases (DUBs) play a critical role in ubiquitin-directed signaling by catalytically removing the ubiquitin from substrate proteins. Ubiquitin-specific protease 15 (USP15), a member of the largest subfamily of cysteine protease DUBs, contains two conservative cysteine (Cys) and histidine (His) boxes. USP15 harbors two zinc-binding motifs that are essential for recognition of poly-ubiquitin chains. USP15 is grouped into the same category with USP4 and USP11 due to high degree of homology in an N-terminal region consisting of domains present in ubiquitin-specific proteases (DUSP) domain and ubiquitin-like (UBL) domain...
February 24, 2017: International Journal of Molecular Sciences
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