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https://www.readbyqxmd.com/read/28105143/different-forms-of-adiponectin-reduce-the-apoptotic-and-damaging-effect-of-cigarette-smoke-extract-on-human-bronchial-epithelial-cells
#1
Meng-Yu Cheng, Hu Liu, Tie-Mei Zhang, Jian-Ying Xu
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease, in which adiponectin may serve an important role. The present study investigated the role of adiponectin in the apoptotic and damaging effect of cigarette smoke extract (CSE) on human bronchial epithelial cells (16HBECs). An MTT assay showed that CSE significantly inhibited the proliferation of 16HBECs (F=1808.88, P<0.01). The 16HBECs were treated with different concentrations of high molecular weight (HMW) adiponectin and globular domain (gAd) adiponectin and it was observed that HMW and gAd dose-dependently inhibited the expression of tumor necrosis factor (TNF)-α and interleukin (IL)-8, and the generation of 4-hydroxy-nonenal and reactive oxygen species (ROS) in 16HBECs, thereby blocking the upregulating effect of CSE on these factors...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100884/stabilization-of-neem-oil-biodiesel-with-corn-silk-extract-during-long-term-storage
#2
Rehab Farouk M Ali, Ayman M El-Anany
The current study aimed to evaluate the antioxidant efficiency of different extracts of corn silk. In addition, the impact of corn silk extract on oxidative stability of neem biodiesel during storage was studied. The highest phenolics, DPPH radical scavenging and reducing power activities were recorded for methanol-water extract. The longest oxidation stability (10 h) was observed for biodiesel samples blended with 1000 ppm of corn silk extract (CSE). At the end of storage period the induction time of biodiesel samples mixed with 1000 ppm of CSE or butylated hydroxytoluene (BHT) were about 6...
January 18, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28099175/two-for-one-a-case-report-of-intravenous-lipid-emulsion-to-treat-local-anesthetic-systemic-toxicity-in-term-pregnancy
#3
Jonathan Dun-Chi Lin, Eellan Sivanesan, Terese T Horlocker, Andres Missair
Combined spinal-epidural (CSE) analgesia is a frequently used method of labor analgesia. Although it is considered safe and effective, CSE can be complicated by local anesthetic systemic toxicity (LAST), a potentially life-threatening condition. We present a case of LAST that developed in a primigravida 50 minutes after uneventful placement of a CSE. Her symptoms resolved within 10 minutes of administering intralipid emulsion. She subsequently underwent cesarean delivery under spinal anesthesia for failure to progress without sequelae in the mother or infant...
January 17, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28095005/identifying-stimuli-that-cue-multiple-responses-triggers-the-congruency-sequence-effect-independent-of-response-conflict
#4
Daniel H Weissman, Katelyn M Colter, Lauren D Grant, Patrick G Bissett
According to most accounts of executive control, resisting distraction requires enhancing task-relevant processing, reducing task-irrelevant processing, or both. Consistent with this view, the congruency effect in Stroop-like tasks-a putative measure of distraction-is often smaller after highly distracting incongruent trials than after less distracting congruent trials. Competing accounts of executive control, however, differ on which aspect of an incongruent trial triggers this congruency sequence effect (CSE)...
January 16, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28087442/hydrogen-sulfide-protects-against-endoplasmic-reticulum-stress-and-mitochondrial-injury-in-nucleus-pulposus-cells-and-ameliorates-intervertebral-disc-degeneration
#5
Daoliang Xu, Haiming Jin, Jianxia Wen, Jiaoxiang Chen, Deheng Chen, Ningyu Cai, Yongli Wang, Jianle Wang, Yu Chen, Xiaolei Zhang, Xiangyang Wang
It has been suggested that excessive apoptosis in intervertebral disc cells induced by inflammatory cytokines, such as interleukin (IL)-1β, is related to the process of intervertebral disc degeneration (IVDD). Hydrogen sulfide (H2S), a gaseous signaling molecule, has drawn attention for its anti-apoptosis role in various pathophysiological processes in degenerative diseases. To date, there has been no investigation of the correlation of H2S production and IVDD or of the effects of H2S on IL-1β-induced apoptosis in nucleus pulposus (NP) cells...
January 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28075397/the-sulfur-metabolite-lanthionine-evidence-for-a-role-as-a-novel-uremic-toxin
#6
REVIEW
Alessandra F Perna, Miriam Zacchia, Francesco Trepiccione, Diego Ingrosso
Lanthionine is a nonproteinogenic amino acid, composed of two alanine residues that are crosslinked on their β-carbon atoms by a thioether linkage. It is biosynthesized from the condensation of two cysteine molecules, while the related compound homolanthionine is formed from the condensation of two homocysteine molecules. The reactions can be carried out by either cystathionine-β-synthase (CBS) or cystathionine-γ-lyase (CSE) independently, in the alternate reactions of the transsulfuration pathway devoted to hydrogen sulfide biosynthesis...
January 10, 2017: Toxins
https://www.readbyqxmd.com/read/28072377/core-self-evaluations-and-job-and-life-satisfaction-the-mediating-and-moderated-mediating-role-of-job-insecurity
#7
Hui-Hsien Hsieh, Jie-Tsuen Huang
This study examined the mediating role of job insecurity in the relationship between core self-evaluations (CSE) and job satisfaction, while also investigating the moderating role of job insecurity in the mediated relationship between CSE and life satisfaction via job satisfaction. Survey data were collected from a sample of 346 full-time employees in Taiwan. We found that job insecurity partially mediated the CSE-job satisfaction relationship. Moreover, we found that job insecurity moderated not only the relationship between CSE and job satisfaction but also the mediated relationship between CSE and life satisfaction via job satisfaction...
January 10, 2017: Journal of Psychology
https://www.readbyqxmd.com/read/28067853/capparis-spinosa-fruit-ethanol-extracts-exert-different-effects-on-the-maturation-of-dendritic-cells
#8
Azeguli Hamuti, Jinyu Li, Fangfang Zhou, Adila Aipire, Ji Ma, Jianhua Yang, Jinyao Li
Capparis spinosa L. (C. spinosa) has been used as food and traditional medicine and shows anti-inflammatory and anti-oxidant activities. Here, we prepared the C. spinosa fruit ethanol extracts (CSEs) using different procedures and investigated the effects of CSE on the maturation of mouse bone marrow-derived dendritic cells (DCs) in the absence or presence of lipopolysaccharide (LPS). DC maturation and cytokine production were detected by flow cytometry and ELISA, respectively. We obtained three different CSEs and dissolved in water or DMSO, named CSE2W, CSEMW, CSE3W, CSE2D, CSEMD, and CSE3D, respectively...
January 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28067707/dural-puncture-epidural-technique-improves-labor-analgesia-quality-with-fewer-side-effects-compared-with-epidural-and-combined-spinal-epidural-techniques-a-randomized-clinical-trial
#9
Anthony Chau, Carolina Bibbo, Chuan-Chin Huang, Kelly G Elterman, Eric C Cappiello, Julian N Robinson, Lawrence C Tsen
BACKGROUND: The dural puncture epidural (DPE) technique is a modification of the combined spinal epidural (CSE) technique, where a dural perforation is created from a spinal needle but intrathecal medication administration is withheld. The DPE technique has been shown to improve caudal spread of analgesia compared with epidural (EPL) technique without the side effects observed with the CSE technique. We hypothesized that the onset of labor analgesia would follow this order: CSE > DPE > EPL techniques...
February 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28065983/herschel-hifi-observations-of-the-circumstellar-ammonia-lines-in-irc-10216
#10
M R Schmidt, J H He, R Szczerba, V Bujarrabal, J Alcolea, J Cernicharo, L Decin, K Justtanont, D Teyssier, K M Menten, D A Neufeld, H Olofsson, P Planesas, A P Marston, A M Sobolev, A de Koter, F L Schöier
CONTEXT: A discrepancy exists between the abundance of ammonia (NH3) derived previously for the circumstellar envelope (CSE) of IRC+10216 from far-IR submillimeter rotational lines and that inferred from radio inversion or mid-infrared (MIR) absorption transitions. AIMS: To address the discrepancy described above, new high-resolution far-infrared (FIR) observations of both ortho- and para-NH3 transitions toward IRC+10216 were obtained with Herschel, with the goal of determining the ammonia abundance and constraining the distribution of NH3 in the envelope of IRC+10216...
August 2016: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/28063978/attitudes-about-race-predict-individual-differences-in-face-adaptation-aftereffects
#11
Sarah L Elliott, Kelly Chu, Jill Coleman
This study examined whether category boundaries between Black and White faces relate to individual attitudes about race. Fifty-seven (20 Black, 37 White) participants completed measures of explicit racism, implicit racism, collective self-esteem (CSE), and racial centrality. Category boundaries between Black and White faces were measured in three separate conditions: following adaptation to (1) a neutral gray background, a sequence of (2) Black or (3) White faces. Two additional conditions measured category boundaries for facial distortion to investigate whether attitudes relate to mechanisms of racial identity alone, or to more global mechanisms of face perception...
January 4, 2017: Vision Research
https://www.readbyqxmd.com/read/28051338/activity-dependent-sulfhydration-signal-controls-nmdar-dependent-synaptic-plasticity-via-increasing-d-serine-availability
#12
Yuan-Long Li, Pei-Fei Wu, Jian-Guo Chen, Sheng Wang, Qian-Qian Han, Dan Li, Wen Wang, Xin-Lei Guan, Di Li, Li-Hong Long, Jian-Geng Huang, Fang Wang
AIMS: Reactive sulfur species (RSS) including hydrogen sulfide (H2S) and its oxydates have been raised as novel redox signaling molecules. The present study aimed at examining whether endogenous sulfhydration signal are required for long-term potentiation (LTP), a cellular model for memory. RESULTS: Here, we found that increased synaptic activity triggered sulfide generationand protein sulfhydration. Activity-triggered sulfide production was essential for N-methyl-D-aspartate subtype glutamate receptors (NMDARs)-dependent LTP via maintaining the availability of D-serine, a primary co-agonist for synaptic NMDARs...
January 4, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28049024/1-4-naphthoquinone-activates-the-hsp90-hsf1-pathway-through-the-s-arylation-of-hsp90-in-a431-cells-negative-regulation-of-the-redox-signal-transduction-pathway-by-persulfides-polysulfides
#13
Yumi Abiko, Liang Sha, Yasuhiro Shinkai, Takamitsu Unoki, Nho Cong Luong, Yukihiro Tsuchiya, Yasuo Watanabe, Reiko Hirose, Takaaki Akaike, Yoshito Kumagai
The current consensus is that environmental electrophiles activate redox signal transduction pathways through covalent modification of sensor proteins with reactive thiol groups at low concentrations, while they cause cell damage at higher concentrations. We previously exposed human carcinoma A431 cells to the atmospheric electrophile 1,4-naphthoquinone (1,4-NQ) and found that heat shock protein 90 (HSP90), a negative regulator of heat shock factor 1 (HSF1), was a target of 1,4-NQ. In the study presented here, we determined whether 1,4-NQ activates HSF1...
December 31, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28042862/hydrogen-sulfide-in-the-adipose-tissue-physiology-pathology-and-a-target-for-pharmacotherapy
#14
REVIEW
Jerzy Bełtowski, Anna Jamroz-Wiśniewska
Hydrogen sulfide (H₂S) is synthesized in the adipose tissue mainly by cystathionine γ-lyase (CSE). Several studies have demonstrated that H₂S is involved in adipogenesis, that is the differentiation of preadipocytes to adipocytes, most likely by inhibiting phosphodiesterases and increasing cyclic AMP concentration. The effect of H₂S on adipose tissue insulin sensitivity and glucose uptake is controversial. Some studies suggest that H₂S inhibits insulin-induced glucose uptake and that excess of H₂S contributes to adipose tissue insulin resistance in metabolic syndrome...
December 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28040865/cse-database-extended-annotations-and-new-recommendations-for-ecg-software-testing
#15
Radovan Smíšek, Lucie Maršánová, Andrea Němcová, Martin Vítek, Jiří Kozumplík, Marie Nováková
Nowadays, cardiovascular diseases represent the most common cause of death in western countries. Among various examination techniques, electrocardiography (ECG) is still a highly valuable tool used for the diagnosis of many cardiovascular disorders. In order to diagnose a person based on ECG, cardiologists can use automatic diagnostic algorithms. Research in this area is still necessary. In order to compare various algorithms correctly, it is necessary to test them on standard annotated databases, such as the Common Standards for Quantitative Electrocardiography (CSE) database...
December 31, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28040015/comparing-the-perceptual-contributions-of-cochlear-scaled-entropy-and-speech-level
#16
Yilai Shu, Xiao-Xing Feng, Fei Chen
Cochlear-scaled entropy (CSE) has been suggested to be a reliable predictor of speech intelligibility. Previous studies showed that speech segments with high root-mean-square (RMS) levels (H-levels) contained primarily vowels, which carry important information for speech recognition. The present work compared the contributions of high-CSE (H-entropy) and H-level segments to speech intelligibility. The natural speech was edited to generate two types of noise-replaced stimuli, which preserved the same percentages of largest CSE segments and highest RMS-level segments, and played to normal-hearing listeners in a recognition experiment...
December 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28034716/dichotomous-effects-of-isomeric-secondary-amines-containing-an-aromatic-nitrile-and-nitro-group-on-human-aortic-smooth-muscle-cells-via-inhibition-of-cystathionine-%C3%AE-lyase
#17
Yajing Ji, Austin Bowersock, Alec R Badour, Neeraj Vij, Stephen J Juris, David E Ash, Dillip K Mohanty
Excessive proliferation of vascular smooth muscle cells (SMC) is an important contributor to the progression of atherosclerosis. Inhibition of proliferation can be achieved by endogenously produced and exogenously supplied nitrogen monoxide, commonly known as nitric oxide (NO). We report herein the dichotomous effects of two isomeric families of secondary amines, precursors to the N-nitrosated NO-donors, on HASMC proliferation. The syntheses of these two families were carried out using two equivalents of homologous, aliphatic monoamines and 2,6-difluoro-3-nitrobenzonitrile (2,6-DFNBN, O family) or 2,4-difluoro-5-nitrobenzonitrile (2,4-DFNBN, P family)...
December 26, 2016: Biochimie
https://www.readbyqxmd.com/read/28033307/effect-of-sodium-valproate-on-cognitive-function-and-hippocampus-of-rats-after-convulsive-status-epilepticus
#18
Peng Wu, Siqi Hong, Min Zhong, Yi Guo, Hengsheng Chen, Li Jiang
BACKGROUND The aim of this study was to explore the effect and possible mechanism of sodium valproate (VPA) on the cognitive function and the hippocampus of rats after convulsive status epilepticus (CES). MATERIAL AND METHODS A rat model of CES was established and the Morris water maze was used to observe changes in the cognitive function of the rats after the administration of VPA. Acute hippocampal slices were made to detect field excitatory postsynaptic potential. Western blot analysis was used to test for the expression of CaMKII and p-CaMKII...
December 29, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28012925/cigarette-smoke-extract-induces-epithelial-mesenchymal-transition-of-human-bladder-cancer-t24-cells-through-activation-of-erk1-2-pathway
#19
Xin Sun, Qifei Deng, Zhaofeng Liang, Zhiqi Liu, Hao Geng, Li Zhao, Qirui Zhou, Jie Liu, Jiaxing Ma, Daming Wang, Dexin Yu, Caiyun Zhong
Bladder cancer is a common genitourinary malignant disease worldwide. Abundant evidence has shown that cigarette smoke (CS) is a crucial risk factor for bladder cancer. Nevertheless, the mechanism underlying the relationship between cigarette smoking and bladder cancer remains unclear. In the present study, we investigated the effects of cigarette smoke extract (CSE) on mitogen-activated protein kinase (MAPK) pathway activation and EMT alterations in human bladder cancer T24 cells, and the preventive effect of extracellular regulated protein kinases 1 and 2 (ERK1/2) inhibitor U0126 was further examined...
December 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28011786/varmatch-robust-matching-of-small-variant-datasets-using-flexible-scoring-schemes
#20
Chen Sun, Paul Medvedev
MOTIVATION: Small variant calling is an important component of many analyses, and, in many instances, it is important to determine the set of variants which appear in multiple callsets. Variant matching is complicated by variants that have multiple equivalent representations. Normalization and decomposition algorithms have been proposed, but are not robust to different representation of complex variants. Variant matching is also usually done to maximize the number of matches, as opposed to other optimization criteria...
December 23, 2016: Bioinformatics
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