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https://www.readbyqxmd.com/read/28736174/effects-of-cigarette-smoke-extracts-on-cell-cycle-cell-migration-and-endocrine-activity-in-human-placental-cells
#1
Cho-Won Kim, Hae-Miru Lee, Kyuhong Lee, Bumseok Kim, Moo-Yeol Lee, Kyung-Chul Choi
Maternal smoking during pregnancy is known to be related to adverse pregnancy results associated with trophoblast proliferation and cell cycle progression. Moreover, many previous studies have shown that cigarette smoke is correlated with human chorionic gonadotropin beta (hCG-β) subunit produced from syncytiotrophoblasts during pregnancy. Thus, we further investigated whether cigarette smoke extract (CSE) affects the cell proliferation, migration and endocrine hormone activity of JEG-3 human placental cancer cells...
July 20, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28728276/-the-role-of-hur-in-mediating-snail-expression-in-human-small-airway-epithelium-induced-by-cigarette-smoke-extract
#2
X M Gu, X G Wang, J Sun, N Wang, S J Jiang
Objective: To investigate the abundance of human antigen R (HuR) in small airway epithelial cells stimulated by cigarette smoke extract (CSE) as well as the role of HuR in mediating snail which is recognized as a key transcription factor in regulating epithelial-mesenchymal transition (EMT). Methods: Human small airway epithelial cells (HSAEpiC) cultured in vitro were exposed to cigarette smoke extract (CSE) to model COPD status. Real-time PCR and western blotting analysis were used in detecting HuR protein and mRNA expression in cells with CSE which were divided into 5 groups: a control group, a 1%-24 h group, a 3%-24 h group, a 1%-48 h group and a 3%-48 h group...
July 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28720648/neutrophil-extracellular-traps-induced-by-cigarette-smoke-activate-plasmacytoid-dendritic-cells
#3
Shi-Lin Qiu, Hui Zhang, Qi-Ya Tang, Jing Bai, Zhi-Yi He, Jian-Quan Zhang, Mei-Hua Li, Jing-Min Deng, Guang-Nan Liu, Xiao-Ning Zhong
BACKGROUND: Neutrophil extracellular traps (NETs) represent a distinct strategy by which neutrophils trap, confine and eliminate invading microorganisms. Emerging evidence suggests that NETs exert a deleterious effect to the host in the absence of microbial stimuli. However, the role of NETs in smoking-related lung diseases remains to be elucidated. OBJECTIVES: To evaluate the formation of NETs in the context of chronic inflammation induced by cigarette smoking and explore its potential role in an experimental mouse model of emphysema...
July 18, 2017: Thorax
https://www.readbyqxmd.com/read/28720485/ceftaroline-modulates-the-innate-immune-and-host-defense-responses-of-immunocompetent-cells-exposed-to-cigarette-smoke
#4
A Bruno, C Cipollina, S Di Vincenzo, L Siena, P Dino, F Di Gaudio, M Gjomarkaj, E Pace
BACKGROUND: Cigarette smoke, the principal risk factor for chronic obstructive pulmonary disease (COPD), negatively influences the effectiveness of the immune system's response to a pathogen. The antibiotic ceftaroline exerts immune-modulatory effects in bronchial epithelial cells exposed to cigarette smoke. AIMS AND METHODS: The present study aims to assess the effects of ceftaroline on TLR2 and TLR4 expression, LPS binding and TNF-α and human beta defensin (HBD2) release in an undifferentiated and PMA-differentiated human monocyte cell line (THP-1) exposed or not to cigarette smoke extracts (CSE)...
July 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28720320/hydrogen-sulfide-improves-diabetic-wound-healing-in-ob-ob-mice-via-attenuating-inflammation
#5
Huichen Zhao, Shengxia Lu, Jiachao Chai, Yuchao Zhang, Xiaoli Ma, Jicui Chen, Qingbo Guan, Meiyan Wan, Yuantao Liu
BACKGROUND: The proposed mechanisms of impaired wound healing in diabetes involve sustained inflammation, excess oxidative stress and compromised agiogenesis. Hydrogen sulfide (H2S) has been reported to have multiple biological activities. We aim to investigate the role of H2S in impaired wound healing in ob/ob mice and explore the possible mechanisms involved. PROCEDURES: Full-thickness skin dorsal wounds were created on ob/ob mice and C57BL/6 mice. Cystathionine-γ-lyase (CSE) expression and H2S production were determined in granulation tissues of the wounds...
June 30, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28709848/hydrogen-sulfide-alleviates-placental-injury-induced-by-maternal-cigarette-smoke-exposure-during-pregnancy-in-rats
#6
Fusheng Zhao, Fang Lei, Senfeng Zhang, Xiang Yan, Wen Wang, Yu Zheng
Maternal cigarette smoke exposure (CSE) during pregnancy is a well recognized causative factor for placental injury. Hydrogen sulfide (H2S), a gaseous signal molecule, has been shown to exert a protective effect against tissue injury in many organs. This study aimed to investigate whether H2S could alleviate CSE-induced placental injury in rats. Pregnant SD rats were randomly divided into 4 groups: NaCl, CSE, CSE + NaHS (a donor of H2S) and NaHS. On gestational day 21, placental weight was measured. Placental H2S content was assessed by methylene blue method...
July 11, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28708037/greater-sensitivity-of-oral-fibroblasts-to-smoked-vs-smokeless-tobacco
#7
Thomas E Lallier, John T Moylan, Erin Maturin
OBJECTIVE: Smokers have an increased incidence and severity of periodontal disease. While cigarette smoke contains over 4,000 chemical components that could affect periodontal tissues, less is understood about the effect of smokeless tobacco. Therefore, this study compared the effects of cigarette smoke extract (CSE) to smokeless tobacco extract (STE) on cell survival and motility of periodontal ligament (PDL) and gingival fibroblasts in vitro. METHODS: PDL and gingival fibroblasts were exposed to varying concentrations of CSE, STE or nicotine alone...
July 14, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28705807/augmentation-of-cgmp-pkg-pathway-and-colonic-motility-by-hydrogen-sulfide
#8
Ancy D Nalli, Sayak Bhattacharya, Hongxia Wang, Derek M Kendig, John R Grider, Karnam S Murthy
Hydrogen sulfide (H2S), like nitric oxide (NO), causes smooth muscle relaxation, but unlike NO, does not stimulate soluble guanylyl cyclase (sGC) activity and generate cGMP. The aim of this study was to investigate the interplay between NO and H2S in colonic smooth muscle. In colonic smooth muscle from rabbit, mouse and human, L-cysteine, substrate of cystathionine-γ-lyase (CSE), or NaHS, an H2S donor, inhibited phosphodiesterase 5 (PDE5) activity and augmented the increase in cGMP levels, IP3 receptor phosphorylation at Ser(1756) (measured as a proxy for PKG activation), and muscle relaxation in response to NO donor, s-nitrosoglutathione (GSNO), suggesting augmentation of cGMP/PKG pathway by H2S...
July 13, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28705058/standardized-approach-for-roi-based-measurements-of-proton-density-fat-fraction-and-r2-in-the-liver
#9
Camilo A Campo, Diego Hernando, Tilman Schubert, Candice A Bookwalter, Andrew J Van Pay, Scott B Reeder
OBJECTIVE: The purpose of this study was to evaluate the reproducibility (interreviewer agreement) and repeatability (intrareviewer agreement) of ROI sampling strategies to measure chemical shift-encoded (CSE) MRI-based liver proton density fat fraction (PDFF) and R2* (1 / T2*). A secondary purpose was to standardize ROI-based liver PDFF and R2* measurements by providing a compromise between measurement reproducibility and repeatability and time burden for image analysts. MATERIALS AND METHODS: CSE data from two cohorts were retrospectively analyzed...
July 13, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28699187/does-transcranial-electrical-stimulation-enhance-corticospinal-excitability-of-the-motor-cortex-in-healthy-individuals-a-systematic-review-and-meta-analysis
#10
Thusharika Dissanayaka, Maryam Zoghi, Michael Farrell, Gary F Egan, Shapour Jaberzadeh
Numerous studies have explored the effects of transcranial electrical stimulation (tES) - including anodal transcranial direct current stimulation (a-tDCS), cathodal transcranial direct current stimulation (c-tDCS), transcranial alternative current stimulation (tACS), transcranial random noise stimulation (tRNS) and transcranial pulsed current stimulation (tPCS) - on corticospinal excitability (CSE) in healthy populations. However, the efficacy of these techniques and their optimal parameters for producing robust results have not been studied...
July 12, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28696754/single-photon-interference-due-to-motion-in-an-atomic-collective-excitation
#11
D J Whiting, N Šibalić, J Keaveney, C S Adams, I G Hughes
We experimentally demonstrate the heralded generation of bichromatic single photons from an atomic collective spin excitation (CSE). The photon arrival times display collective quantum beats, a novel interference effect resulting from the relative motion of atoms in the CSE. A combination of velocity-selective excitation with strong laser dressing and the addition of a magnetic field allows for exquisite control of this collective beat phenomenon. The present experiment uses a diamond scheme with near-IR photons that can be extended to include telecommunications wavelengths or modified to allow storage and retrieval in an inverted-Y scheme...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28692844/comparative-bonding-ability-to-dentin-of-a-universal-adhesive-system-and-monomer-conversion-as-functions-of-extended-light-curing-times-and-storage
#12
Paula Costa Pinheiro Sampaio, Paula de Castro Kruly, Clara Cabral Ribeiro, Leandro Augusto Hilgert, Patrícia Nóbrega Rodrigues Pereira, Polliana Mendes Candia Scaffa, Vinicius Di Hipólito, Paulo Henrique Perlatti D'Alpino, Fernanda Cristina Pimentel Garcia
OBJECTIVES: The purpose of this in vitro study was to evaluate the bonding ability and monomer conversion of a universal adhesive system applied to dentin as functions of different curing times and storage. The results were compared among a variety of commercial adhesives. MATERIALS AND METHODS: Flat superficial dentin surfaces were exposed on human molars and assigned into one of the following adhesives (n = 15): total-etch Adper Single Bond 2 (SB) and Optibond Solo Plus (OS), self-etch Optibond All in One (OA) and Clearfil SE Bond (CSE), and Scotchbond Universal Adhesive in self-etch mode (SU)...
June 27, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28690969/two-dimensional-silicon-and-carbon-monochalcogenides-with-the-structure-of-phosphorene
#13
Dario Rocca, Ali Abboud, Ganapathy Vaitheeswaran, Sébastien Lebègue
Phosphorene has recently attracted significant interest for applications in electronics and optoelectronics. Inspired by this material an ab initio study was carried out on new two-dimensional binary materials with a structure analogous to phosphorene. Specifically, carbon and silicon monochalcogenides have been considered. After structural optimization, a series of binary compounds were found to be dynamically stable in a phosphorene-like geometry: CS, CSe, CTe, SiO, SiS, SiSe, and SiTe. The electronic properties of these monolayers were determined using density functional theory...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28689885/reduction-of-hydrogen-sulfide-synthesis-enzymes-cystathionine-%C3%AE-synthase-and-cystathionine-%C3%AE-lyase-in-the-colon-of-patients-with-hirschsprungs-s-disease
#14
Christian Tomuschat, Anne Marie O'Donnell, David Coyle, Prem Puri
PURPOSE: Hirschsprung's associated enterocolitis (HAEC) is the most common cause of morbidity and mortality in Hirschsprung's Disease (HSCR). The pathogenesis of HAEC is poorly understood. In recent years, there is increasing evidence that a compromised intestinal barrier function plays a major role in the pathogenesis of HAEC. Hydrogen sulfide, synthesized from L-cysteine by two key enzymes, cystathionine-β-synthase (CBS) and cystathionine-γ-lysase (CSE) is reported to play a key role in regulating gastrointestinal motility and promoting resolution of inflammation...
June 23, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28682281/microleakage-of-class-ii-composite-resin-restorations-with-self-adhesive-composite-resin-liners
#15
Maryam Doozandeh, Fereshteh Shafiei, Fatemeh Mohammadi
This study investigated the microleakage of Class II composite restorations with composite resin liners. Standardized box cavities were prepared on the mesial and distal surfaces of 84 extracted intact human molars. Proximal margins were located in enamel (occlusal) and 1.0 mm apical to the cementoenamel junction (gingival). The teeth were randomly divided into 6 groups (n = 28 cavities) and restored with Filtek Z350 nanohybrid composite resin (FZ). The test groups were lined with a conventional flowable composite resin, Premise Flowable (PF), or 1 of 2 self-adhesive composites (SACs): Vertise Flow (VF) or Clearfil SA luting cement (CSA) with or without their respective self-etching adhesives: Optibond All-in-One (OB) or Clearfil SE Bond (CSE)...
July 2017: General Dentistry
https://www.readbyqxmd.com/read/28672917/downregulation-of-p16-promotes-cigarette-smoke-extract-induced-vascular-smooth-muscle-cell-proliferation-via-preventing-g1-s-phase-transition
#16
Tao Guo, Xiangping Chai, Qiming Liu, Wen Peng, Zhenyu Peng, Yuzhong Cai
The proliferation of vascular smooth muscle cells (VSMCs) serves an important role in cigarette smoking-associated vascular diseases; however, the underlying mechanisms responsible for this remain unclear. The aim of the present study was to elucidate the role of P16 in cigarette smoke extract (CSE)-induced VSMC proliferation and the underlying mechanism responsible. Human aortic smooth muscle cells (HAOSMCs) were exposed to CSE, and an MTT assay and flow cytometry were performed to evaluate cell proliferation and cell cycle distribution...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28669627/endogenous-hydrogen-sulfide-mediated-mapk-inhibition-preserves-endothelial-function-through-txnip-signaling
#17
Danyang Tian, Jinghui Dong, Sheng Jin, Xu Teng, Yuming Wu
Mounting evidence demonstrated deficient cystathionine-γ-lyase (CSE)/H2S implicated the development of cardiovascular disease. The present study aimed to evaluating the favorable action of CSE derived H2S on endothelial function in CSE(-/-) mice. CSE(-/-) mice exhibited attenuated endothelium-dependent relaxations, coupled with reduction of endothelial nitric oxide synthase (eNOS) phosphorylation at site of Ser1177, increase of thioredoxin interacting protein (TXNIP) level and MAPK phosphorylation, which were corrected by sodium hydrosulfide chronic treatment for 8 weeks...
June 29, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28668968/cigarette-smoke-extract-changes-expression-of-endothelial-nitric-oxide-synthase-enos-and-p16-ink4a-and-is-related-to-endothelial-progenitor-cell-dysfunction
#18
Zhihui He, Yan Chen, Can Hou, Wenfang He, Ping Chen
BACKGROUND Endothelial dysfunction is an important pathophysiologic feature in many smoke-related diseases. Endothelial progenitor cells (EPCs) are the precursors of endothelial cells and play a fundamental role in the maintenance of endothelial integrity and function. Endothelial nitric oxide synthase (eNOS) is the dominant NOS isoform in the vasculature and plays a central role in the maintenance of endothelial homeostasis. p16(INK4a) is a cyclin-dependent kinase inhibitor and could be regarded as a major dominant senescence gene...
July 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28662047/mdd-palm-identification-of-protein-s-palmitoylation-sites-with-substrate-motifs-based-on-maximal-dependence-decomposition
#19
Shun-Long Weng, Hui-Ju Kao, Chien-Hsun Huang, Tzong-Yi Lee
S-palmitoylation, the covalent attachment of 16-carbon palmitic acids to a cysteine residue via a thioester linkage, is an important reversible lipid modification that plays a regulatory role in a variety of physiological and biological processes. As the number of experimentally identified S-palmitoylated peptides increases, it is imperative to investigate substrate motifs to facilitate the study of protein S-palmitoylation. Based on 710 non-homologous S-palmitoylation sites obtained from published databases and the literature, we carried out a bioinformatics investigation of S-palmitoylation sites based on amino acid composition...
2017: PloS One
https://www.readbyqxmd.com/read/28661538/enzymatic-biomineralization-of-biocompatible-cuins2-cuinzn-s2-and-cuins2-zns-core-shell-nanocrystals-for-bioimaging
#20
Leah C Spangler, Roxanne Chu, Li Lu, Christopher J Kiely, Bryan W Berger, Steven McIntosh
This work demonstrates a bioenabled fully aqueous phase and room temperature route to the synthesis of CuInS2/ZnS core/shell quantum confined nanocrystals conjugated to IgG antibodies and used for fluorescent tagging of THP-1 leukemia cells. This elegant, straightforward and green approach avoids the use of solvents, high temperatures and the necessity to phase transfer the nanocrystals prior to application. Non-toxic CuInS2, (CuInZn)S2, and CuInS2/ZnS core/shell quantum confined nanocrystals are synthesized via a biomineralization process based on a single recombinant cystathionine γ-lyase (CSE) enzyme...
July 13, 2017: Nanoscale
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