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https://www.readbyqxmd.com/read/29786653/role-for-cystathionine-%C3%AE-lyase-cse-in-an-ethanol-e-induced-lesion-in-fetal-brain-gsh-homeostasis
#1
Dhyanesh Patel, Marylatha Rathinam, Courtney Jarvis, Lenin Mahimainathan, George Henderson, Madhusudhanan Narasimhan
Earlier, we reported that gestational ethanol (E) can dysregulate neuron glutathione (GSH) homeostasis partially via impairing the EAAC1-mediated inward transport of Cysteine (Cys) and this can affect fetal brain development. In this study, we investigated if there is a role for the transulfuration pathway (TSP), a critical bio-synthetic point to supply Cys in E-induced dysregulation of GSH homeostasis. These studies utilized an in utero E binge model where the pregnant Sprague⁻Dawley (SD) rat dams received five doses of E at 3...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29786020/use-of-international-foundations-of-medicine-clinical-sciences-examination-to-evaluate-students-performance-in-the-local-examination-at-the-university-of-sharjah-united-arab-emirates
#2
Nihar Ranjan Dash, Mohamed Elhassan Abdalla, Amal Hussein
Background: Several medical schools around the world are moving away from isolated, locally developed in-house assessments to the introduction of external examinations into their curriculum. Although the objective varies, it is typically done to evaluate, audit, and compare students' performance to international standards. Similarly, the International Foundations of Medicine-Clinical Sciences Examination (IFOM-CSE) was introduced in the College of Medicine at the University of Sharjah as an external assessment criterion in addition to the existing in-house assessments...
September 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/29781504/epidural-versus-non-epidural-or-no-analgesia-for-pain-management-in-labour
#3
REVIEW
Millicent Anim-Somuah, Rebecca Md Smyth, Allan M Cyna, Anna Cuthbert
BACKGROUND: Epidural analgesia is a central nerve block technique achieved by injection of a local anaesthetic close to the nerves that transmit pain, and is widely used as a form of pain relief in labour. However, there are concerns about unintended adverse effects on the mother and infant. This is an update of an existing Cochrane Review (Epidural versus non-epidural or no analgesia in labour), last published in 2011. OBJECTIVES: To assess the effectiveness and safety of all types of epidural analgesia, including combined-spinal-epidural (CSE) on the mother and the baby, when compared with non-epidural or no pain relief during labour...
May 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29780331/a-novel-murine-chronic-obstructive-pulmonary-disease-model-and-the-pathogenic-role-of-microrna-21
#4
Shengyang He, Liqiu Li, Shenghua Sun, Zhengpeng Zeng, Junjuan Lu, Lihua Xie
Chronic obstructive pulmonary disease (COPD) is a multi-pathogenesis chronic lung disease. The mechanisms underlying COPD have not been adequately illustrated. Many reseachers argue that microRNAs (miRs) could play a crucial role in COPD. The classic animal model of COPD is both time consuming and costly. This study proposes a novel mice COPD model and explores the role of miR-21 in COPD. A total of 50 wide-type (WT) C57BL/6 mice were separated into five euqlly-sized groups-(1) control group (CG), (2) the novel combined method group (NCM, cigarette smoke (CS) exposure for 28 days combined with cigarette smoke extract (CSE) intraperitoneal injection), (3) the short-term CS exposure group (SCSE, CS exposure for 28 days), (4) the CSE intraperitoneal injection group (CSEII, 28 days CSE intraperitoneal injection), and (5) the long-term CS exposure group (LCSE, CS exposure)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29771280/identification-and-characterization-of-moonlighting-long-non-coding-rnas-based-on-rna-and-protein-interactome
#5
Lixin Cheng, Kwong-Sak Leung
Motivation: Moonlighting proteins are a class of proteins having multiple distinct functions, which play essential roles in a variety of cellular and enzymatic functioning systems. Although there have long been calls for computational algorithms for the identification of moonlighting proteins, research on approaches to identify moonlighting long non-coding RNAs (lncRNAs) has never been undertaken. Here, we introduce a novel methodology, MoonFinder, for the identification of moonlighting lncRNAs...
May 16, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29770919/dl-propargylglycine-protects-against-myocardial-injury-induced-by-chronic-intermittent-hypoxia-through-inhibition-of-endoplasmic-reticulum-stress
#6
Xiufang Zhou, Si Tang, Ke Hu, Zhan Zhang, Pei Liu, Yuchuan Luo, Jing Kang, Lifang Xu
BACKGROUND: Chronic intermittent hypoxia (CIH), an important basis of the pathogenesis of organ damage induced by obstructive sleep apnea syndrome (OSAS), is associated with myocardial injury, such as left ventricular dysfunction, apoptosis, and oxidative stress. Endogenous hydrogen sulfide (H2 S) plays an important role in maintaining cardiovascular functions. Many studies have demonstrated that exogenous H2 S has protective effects against myocardial injury induced by various cardiovascular diseases, and inhibiting the generation of endogenous H2 S has opposite effects...
May 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29770432/automated-mandatory-bolus-versus-basal-infusion-for-maintenance-of-epidural-analgesia-in-labour
#7
REVIEW
Ban Leong Sng, Yanzhi Zeng, Nurun Nisa A de Souza, Wan Ling Leong, Ting Ting Oh, Fahad Javaid Siddiqui, Pryseley N Assam, Nian-Lin R Han, Edwin Sy Chan, Alex T Sia
BACKGROUND: Childbirth may cause the most severe pain some women experience in their lifetime. Epidural analgesia is an effective form of pain relief during labour and is considered to be the reference standard. Traditionally epidural analgesia has been delivered as a continuous infusion via a catheter in the epidural space, with or without the ability for the patient to supplement the analgesia received by activating a programmable pump to deliver additional top-up doses, known as patient-controlled epidural analgesia (PCEA)...
May 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29767441/hydrogen-sulfide-pathway-and-skeletal-muscle-an-introductory-review
#8
REVIEW
Valentina Vellecco, Chiara Armogida, Mariarosaria Bucci
The presence of H2 S pathway in skeletal muscle (SKM) has been recently established. SKM expresses the three constitutive H2 S generating enzymes in animals and humans and it actively produces H2 S. The main recognized molecular targets of H2 S, i.e. potassium channels and phosphodiesterases, have been evaluated in SKM physiology in order to hypothesize a role for H2 S signaling. SKM dysfunctions, including muscular dystrophy and malignant hyperthermia, have been also evaluated as conditions in which H2 S-pathway and the trans-sulfuration pathway have been suggested to be involved...
May 16, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29765317/sodium-tanshinone-iia-sulfonate-decreases-cigarette-smoke-induced-inflammation-and-oxidative-stress-via-blocking-the-activation-of-mapk-hif-1%C3%AE-signaling-pathway
#9
Ruijuan Guan, Jian Wang, Ziying Li, Mingjing Ding, Defu Li, Guihua Xu, Tao Wang, Yuqin Chen, Qian Yang, Zhen Long, Zhou Cai, Chenting Zhang, Xue Liang, Lian Dong, Li Zhao, Haiyun Zhang, Dejun Sun, Wenju Lu
Aberrant activation of hypoxia-inducible factor (HIF)-1α is frequently encountered and promotes oxidative stress and inflammation in chronic obstructive pulmonary disease (COPD). The present study investigated whether sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA, can mediate its effect through inhibiting HIF-1α-induced oxidative stress and inflammation in cigarette smoke (CS)-induced COPD in mice. Here, we found that STS improved pulmonary function, ameliorated emphysema and decreased the infiltration of inflammatory cells in the lungs of CS-exposed mice...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29765063/long-non-coding-rna-expression-patterns-in-lung-tissues-of-chronic-cigarette-smoke-induced-copd-mouse-model
#10
Haiyun Zhang, Dejun Sun, Defu Li, Zeguang Zheng, Jingyi Xu, Xue Liang, Chenting Zhang, Sheng Wang, Jian Wang, Wenju Lu
Long non-coding RNAs (lncRNAs) have critical regulatory roles in protein-coding gene expression. Aberrant expression profiles of lncRNAs have been observed in various human diseases. In this study, we investigated transcriptome profiles in lung tissues of chronic cigarette smoke (CS)-induced COPD mouse model. We found that 109 lncRNAs and 260 mRNAs were significantly differential expressed in lungs of chronic CS-induced COPD mouse model compared with control animals. GO and KEGG analyses indicated that differentially expressed lncRNAs associated protein-coding genes were mainly involved in protein processing of endoplasmic reticulum pathway, and taurine and hypotaurine metabolism pathway...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29760703/the-increased-endogenous-sulfur-dioxide-acts-as-a-compensatory-mechanism-for-the-downregulated-endogenous-hydrogen-sulfide-pathway-in-the-endothelial-cell-inflammation
#11
Da Zhang, Xiuli Wang, Xiaoyu Tian, Lulu Zhang, Guosheng Yang, Yinghong Tao, Chen Liang, Kun Li, Xiaoqi Yu, Xinjing Tang, Chaoshu Tang, Jing Zhou, Wei Kong, Junbao Du, Yaqian Huang, Hongfang Jin
Endogenous hydrogen sulfide (H2 S) and sulfur dioxide (SO2 ) are regarded as important regulators to control endothelial cell function and protect endothelial cell against various injuries. In our present study, we aimed to investigate the effect of endogenous H2 S on the SO2 generation in the endothelial cells and explore its significance in the endothelial inflammation in vitro and in vivo . The human umbilical vein endothelial cell (HUVEC) line (EA.hy926), primary HUVECs, primary rat pulmonary artery endothelial cells (RPAECs), and purified aspartate aminotransferase (AAT) protein from pig heart were used for in vitro experiments...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29757921/systematic-review-of-advanced-practice-nurses-skin-cancer-detection-knowledge-and-attitudes-clinical-skin-examination-lesion-detection-and-training
#12
Lois J Loescher, Delaney Stratton, Maribeth Slebodnik, Hope Goodman
BACKGROUND AND PURPOSE: Skin cancer is the most common malignancy in the United States; early detection reduces the public health burden. This systematic review updates the state of advanced practice nurses' skin cancer knowledge and attitudes, performance of and barriers to clinical skin examination (CSE), recognition of skin lesions, and related training activities. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement guided a search of eight literature databases that yielded 12 studies from 2010 to 2016...
January 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29749968/the-mediating-role-of-nurses-professional-commitment-in-the-relationship-between-core-self-evaluation-and-job-satisfaction
#13
Ivana Barać, Nada Prlić, Jadranka Plužarić, Nikolina Farčić, Suzana Kovačević
OBJECTIVES: The aim of this study was to examine the degree to which it is possible to predict job satisfaction in hospital nurses based on core self-evaluation and the nurses' professional commitment. Psychological constructs of nurses' professional commitment could predict a level of job satisfaction. MATERIAL AND METHODS: A cross-sectional design was applied. Data were collected between April 2016 and November 2016 from 584 nurses of the University Hospital Osijek...
May 11, 2018: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29741960/ecological-interface-design-for-computer-network-defense
#14
Kevin B Bennett, Adam Bryant, Christen Sushereba
OBJECTIVE: A prototype ecological interface for computer network defense (CND) was developed. BACKGROUND: Concerns about CND run high. Although there is a vast literature on CND, there is some indication that this research is not being translated into operational contexts. Part of the reason may be that CND has historically been treated as a strictly technical problem, rather than as a socio-technical problem. METHODS: The cognitive systems engineering (CSE)/ecological interface design (EID) framework was used in the analysis and design of the prototype interface...
May 1, 2018: Human Factors
https://www.readbyqxmd.com/read/29730290/cystathionine-gamma-lyase-h-2-s-contributes-to-osteoclastogenesis-during-bone-remodeling-induced-by-mechanical-loading
#15
Shenzheng Mo, Yongmei Hua
Hydrogen sulfide (H2 S), a gaseous signaling molecule produced by cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), influences bone remodeling in many ways. Osteoclasts play an important role in bone remodeling during tooth movement induced by mechanical loading, which increases the rate of tooth movement. Recently, we found that osteoclasts could produce H2 S. However, whether H2 S modulates bone remodeling by affecting osteoclasts remains unclear. In this study, we found that CSE-H2 S was a dominant H2 S generating system in osteoclasts, while CBS did not generate H2 S...
May 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29726907/mican-sq-a-sequential-protein-structure-alignment-program-that-is-applicable-to-monomers-and-all-types-of-oligomers
#16
Shintaro Minami, Kengo Sawada, Motonori Ota, George Chikenji
Motivation: Protein structure alignment is a significant tool to understand evolutionary processes and physicochemical properties of proteins. Important targets of structure alignment are not only monomeric but also oligomeric proteins that sometimes include domain swapping or fusions. Although various protein structural alignment programs have been developed, no method is applicable to any protein pair regardless of the number of chain components and oligomeric states with retaining sequential restrictions: structurally equivalent regions must be aligned in the same order along protein sequences...
May 3, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29726624/regulation-of-eclipta-prostrata-l-components-on-cigarette-smoking-induced-autophagy-of-bronchial-epithelial-cells-via-keap1-nrf2-pathway
#17
Shumin Ding, Xuefeng Hou, Fujing Wang, Gang Wang, Xiaobin Tan, Ying Liu, Yuanli Zhou, Huihui Qiu, E Sun, Nan Jiang, Zihao Li, Jie Song, Liang Feng, Xiaobin Jia
Cigarette smoking extract (CSE)-induced autophagic injury has been regarded as an important contributor to the pathogenesis of lung cancer. We previously found that Eclipta prostrata L. component (CCE) reduced CSE-induced bronchial epithelial cells damage. However, the mechanism remains unknown. Human normal bronchial epithelial cells (NHBE) were exposed to CSE to establish stress model. Nrf2-siRNA and Keap1-siRNA transfection were performed. mRFP-GFP-LC3 dual fluorescence and transmission electron microscopy were used to observe the autophagic characteristics...
May 4, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29722338/inhibition-of-the-hedgehog-signaling-pathway-depresses-the-cigarette-smoke-induced-malignant-transformation-of-16hbe-cells-on-a-microfluidic-chip
#18
Yong-Xin Qin, Zhi-Hui Yang, Xiao-Hui Du, Hui Zhao, Yuan-Bin Liu, Zhe Guo, Qi Wang
Background: The hedgehog signaling system (HHS) plays an important role in the regulation of cell proliferation and differentiation during the embryonic phases. However, little is known about the involvement of HHS in the malignant transformation of cells. This study aimed to detect the role of HHS in the malignant transformation of human bronchial epithelial (16HBE) cells. Methods: In this study, two microfluidic chips were designed to investigate cigarette smoke extract (CSE)-induced malignant transformation of cells...
May 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29720047/comprehensive-sexuality-education-as-a-primary-prevention-strategy-for-sexual-violence-perpetration
#19
Madeline Schneider, Jennifer S Hirsch
Sexual violence (SV) represents a serious public health problem with high rates and numerous health consequences. Current primary prevention strategies to reduce SV perpetration have been shown to be largely ineffective-not surprisingly, since as others have pointed out current prevention largely fails to draw on existing knowledge about the characteristics of effective prevention. In this article, we examine the potential of K-12 comprehensive sexuality education (CSE), guided by the National Sexuality Education Standards (NSES), to be an effective strategy...
January 1, 2018: Trauma, Violence & Abuse
https://www.readbyqxmd.com/read/29712741/cystathionine-%C3%AE-lyase-produced-hydrogen-sulfide-controls-endothelial-no-bioavailability-and-blood-pressure
#20
István András Szijártó, Lajos Markó, Milos R Filipovic, Jan Lj Miljkovic, Christoph Tabeling, Dmitry Tsvetkov, Ning Wang, Luiza A Rabelo, Martin Witzenrath, André Diedrich, Jens Tank, Noriyuki Akahoshi, Shotaro Kamata, Isao Ishii, Maik Gollasch
Hydrogen sulfide (H2 S) and NO are important gasotransmitters, but how endogenous H2 S affects the circulatory system has remained incompletely understood. Here, we show that CTH or CSE (cystathionine γ-lyase)-produced H2 S scavenges vascular NO and controls its endogenous levels in peripheral arteries, which contribute to blood pressure regulation. Furthermore, eNOS (endothelial NO synthase) and phospho-eNOS protein levels were unaffected, but levels of nitroxyl were low in CTH-deficient arteries, demonstrating reduced direct chemical interaction between H2 S and NO...
April 30, 2018: Hypertension
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