keyword
https://read.qxmd.com/read/37400771/associations-of-circulating-proteins-with-lipoprotein-profiles-proteomic-analyses-from-the-omniheart-randomized-trial-and-the-atherosclerosis-risk-in-communities-aric-study
#21
JOURNAL ARTICLE
Hyunju Kim, Alice H Lichtenstein, Peter Ganz, Edgar R Miller, Josef Coresh, Lawrence J Appel, Casey M Rebholz
BACKGROUND: Within healthy dietary patterns, manipulation of the proportion of macronutrient can reduce CVD risk. However, the biological pathways underlying healthy diet-disease associations are poorly understood. Using an untargeted, large-scale proteomic profiling, we aimed to (1) identify proteins mediating the association between healthy dietary patterns varying in the proportion of macronutrient and lipoproteins, and (2) validate the associations between diet-related proteins and lipoproteins in the Atherosclerosis Risk in Communities (ARIC) Study...
July 3, 2023: Clinical Proteomics
https://read.qxmd.com/read/37365502/regulatory-mechanisms-and-therapeutic-potential-of-jab1-in-neurological-development-and-disorders
#22
REVIEW
Yu Yang, Ruying Song, Yiming Gao, Hao Yu, Shuai Wang
c-Jun activation domain binding protein-1 (JAB1) is a multifunctional regulator that plays vital roles in diverse cellular processes. It regulates AP-1 transcriptional activity and also acts as the fifth component of the COP9 signalosome complex. While JAB1 is considered an oncoprotein that triggers tumor development, recent studies have shown that it also functions in neurological development and disorders. In this review, we summarize the general features of the JAB1 gene and protein, and present recent updates on the regulation of JAB1 expression...
June 26, 2023: Molecular Medicine
https://read.qxmd.com/read/37202390/fbxw7%C3%AE-loss-of-function-enhances-fasn-mediated-lipogenesis-and-promotes-colorectal-cancer-growth
#23
JOURNAL ARTICLE
Wenxia Wei, Baifu Qin, Weijie Wen, Boyu Zhang, Haidan Luo, Yuzhi Wang, Hui Xu, Xiaoshan Xie, Sicheng Liu, Xin Jiang, Mengan Wang, Qin Tang, Jiayu Zhang, Runxiang Yang, Zongmin Fan, Haiwen Lyu, Junzhong Lin, Kai Li, Mong-Hong Lee
Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor. FBXW7 is a highly mutated gene in CRC, but its biological functions in cancer are not fully characterized. Here, we report that FBXW7β, a FBXW7 isoform located in the cytoplasm and frequently mutated in CRC, is an E3 ligase of fatty acid synthase (FASN). Cancer-specific FBXW7β mutations that could not degrade FASN can lead to sustained lipogenesis in CRC. COP9 signalosome subunit 6 (CSN6), an oncogenic marker of CRC, increases lipogenesis via interacting with and stabilizing FASN...
May 19, 2023: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/37201626/cops3-inhibition-promotes-cell-proliferation-blockage-and-anoikis-via-regulating-pfkfb3-in-osteosarcoma-cancer-cells
#24
JOURNAL ARTICLE
Fan Zhang, Qianqian Li, Yaqin Zhang, Na Li, Mengjiao Rao, Shi Li, Zhiying Ai, Siyuan Yan, Zhichao Tian
As a key component of the COP9 signalosome complex, which participates in a variety of physiological processes, COPS3 is intimately related to multiple cancers. It promotes cell proliferation, progression and metastasis in several cancer cells. However, whether COPS3 participates in regulating anoikis, a specific kind of apoptosis and functions as an essential modulator of cell metastasis, has not yet been studied. Here, we found COPS3 is highly expressed in several cancers especially in osteosarcoma (OS). Overexpression of COPS3 promoted cell proliferation, cell viability and migration/invasion in both control cells and oxaliplatin (Oxa) treated cells...
May 16, 2023: European Journal of Pharmacology
https://read.qxmd.com/read/37168110/the-cop9-signalosome-complex-regulates-fungal-development-and-virulence-in-the-wheat-scab-fungus-fusarium-graminearum
#25
JOURNAL ARTICLE
Ahai Chen, Yiyi Ren, Xingmin Han, Chao Liu, Yifan Zhou, Chenghui Xu, Hao Qi, Zhonghua Ma, Yun Chen
The COP9 signalosome (Csn) complex is an evolutionarily conserved complex that regulates various important cellular processes. However, the function of the Csn complex in pathogenic fungi remains elusive. Here, the distribution of Csn subunits in the fungal kingdom was surveyed, and their biological functions were systematically characterized in the fungal pathogen Fusarium graminearum , which is among the top 10 plant fungal pathogens. The results obtained from bioinformatic analyses suggested that the F. graminearum Csn complex consisted of seven subunits (Csn1-Csn7) and that Csn5 was the most conserved subunit across the fungi kingdom...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37116498/a-global-genetic-interaction-network-by-single-cell-imaging-and-machine-learning
#26
JOURNAL ARTICLE
Florian Heigwer, Christian Scheeder, Josephine Bageritz, Schayan Yousefian, Benedikt Rauscher, Christina Laufer, Sergi Beneyto-Calabuig, Maja Christina Funk, Vera Peters, Maria Boulougouri, Jana Bilanovic, Thilo Miersch, Barbara Schmitt, Claudia Blass, Fillip Port, Michael Boutros
Cellular and organismal phenotypes are controlled by complex gene regulatory networks. However, reference maps of gene function are still scarce across different organisms. Here, we generated synthetic genetic interaction and cell morphology profiles of more than 6,800 genes in cultured Drosophila cells. The resulting map of genetic interactions was used for machine learning-based gene function discovery, assigning functions to genes in 47 modules. Furthermore, we devised Cytoclass as a method to dissect genetic interactions for discrete cell states at the single-cell resolution...
April 25, 2023: Cell Systems
https://read.qxmd.com/read/37091236/latent-csn-crl-complexes-are-crucial-for-curcumin-induced-apoptosis-and-recruited-during-adipogenesis-to-lipid-droplets-via-small-gtpase-rab18
#27
JOURNAL ARTICLE
Dawadschargal Dubiel, Jing Wang, Roland Hartig, Supattra Chaithongyot, Wolfgang Dubiel, Michael Naumann
The COP9 signalosome (CSN) and cullin-RING ubiquitin ligases (CRLs) form latent CSN-CRL complexes detectable in cells. We demonstrate that the CSN variants CSNCSN7A and CSNCSN7B preferentially bind to CRL3 or CRL4A and CRL4B, respectively. Interestingly, the interacting protein ubiquitin-specific protease 15 exclusively binds to latent CSNCSN7A -CRL3, while p27KIP attaches to latent CSNCSN7B -CRL4A complex. Inhibition of deneddylation by CSN5i-3 or neddylation by MLN4924 do not impede the formation of latent complexes...
April 21, 2023: IScience
https://read.qxmd.com/read/37090553/cop9-signalosome-promotes-neointimal-hyperplasia-via-deneddylation-and-csn5-mediated-nuclear-export
#28
Samiksha Giri, Chao Suo, Ruggero Pardi, Gregory A Fishbein, Khosrow Rezvani, Yabing Chen, Xuejun Wang
BACKGROUND: Neointimal hyperplasia (NH) is a common pathological response to vascular injury and mediated primarily by vascular smooth muscle cell (VSMC) migration and proliferation. The COP9 signalosome (CSN) is formed by 8 canonical subunits (CSN1 through CSN8) with its deneddylation activity residing in CSN5. Each or some of CSN subunits may have deneddylation-independent function. Despite strong evidence linking the CSN to cell cycle regulation in cancer cells, the role of the CSN in vascular biology remains obscure...
April 12, 2023: bioRxiv
https://read.qxmd.com/read/37067025/inactivation-of-cops5-in-smooth-muscle-cells-causes-abnormal-reproductive-hormone-homeostasis-and-development-in-mice
#29
JOURNAL ARTICLE
Qian Huang, Yonghong Man, Wei Li, Qi Zhou, Shuo Yuan, Yi Tian Yap, Neha Nayak, Ling Zhang, Shizheng Song, Joseph Dunbar, Todd Leff, Xu Yang, Zhibing Zhang
COP9 constitutive photomorphogenic homolog subunit 5 (COPS5), also known as Jab1 or CSN5, has been implicated in a wide variety of cellular and developmental processes. By analyzing male germ cell-specific COPS5-deficient mice, we have demonstrated previously that COPS5 is essential to maintain male germ survival and acrosome biogenesis. To further determine the role of Cops5 in peritubular myoid cells, a smooth muscle lineage surrounding seminiferous tubules, we herein derived mice conditionally deficient for the Cops5 gene in smooth muscle cells using transgenic Myh11-Cre mice...
April 17, 2023: Endocrinology
https://read.qxmd.com/read/37045830/pkd-phosphorylation-and-cop9-signalosome-modulate-intracellular-spry2-protein-stability
#30
JOURNAL ARTICLE
Natalia Martínez, Teresa Gragera, María Pilar de Lucas, Ana Belén Cámara, Alicia Ballester, Berta Anta, Alberto Fernández-Medarde, Tania López-Briones, Judith Ortega, Daniel Peña-Jiménez, Antonio Barbáchano, Ana Montero-Calle, Víctor Cordero, Rodrigo Barderas, Teresa Iglesias, Mónica Yunta, José Luís Oliva, Alberto Muñoz, Eugenio Santos, Natasha Zarich, José M Rojas-Cabañeros
Spry2 is a molecular modulator of tyrosine kinase receptor signaling pathways that has cancer-type-specific effects. Mammalian Spry2 protein undergoes tyrosine and serine phosphorylation in response to growth factor stimulation. Spry2 expression is distinctly altered in various cancer types. Inhibition of the proteasome functionality results in reduced intracellular Spry2 degradation. Using in vitro and in vivo assays, we show that protein kinase D (PKD) phosphorylates Spry2 at serine 112 and interacts in vivo with the C-terminal half of this protein...
April 12, 2023: Oncogenesis
https://read.qxmd.com/read/36997676/tespa1-facilitates-hematopoietic-and-leukemic-stem-cell-maintenance-by-restricting-c-myc-degradation
#31
JOURNAL ARTICLE
Yukai Lu, Lijing Yang, Mingqiang Shen, Zihao Zhang, Song Wang, Fang Chen, Naicheng Chen, Yang Xu, Hao Zeng, Mo Chen, Shilei Chen, Fengchao Wang, Mengjia Hu, Junping Wang
Hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) have robust self-renewal potential, which is responsible for sustaining normal and malignant hematopoiesis, respectively. Although considerable efforts have been made to explore the regulation of HSC and LSC maintenance, the underlying molecular mechanism remains obscure. Here, we observe that the expression of thymocyte-expressed, positive selection-associated 1 (Tespa1) is markedly increased in HSCs after stresses exposure. Of note, deletion of Tespa1 results in short-term expansion but long-term exhaustion of HSCs in mice under stress conditions due to impaired quiescence...
March 30, 2023: Leukemia
https://read.qxmd.com/read/36835523/transcriptomic-and-bioinformatic-analyses-identifying-a-central-mif-cop9-nf-kb-signaling-network-in-innate-immunity-response-of-ciona-robusta
#32
JOURNAL ARTICLE
Laura La Paglia, Mirella Vazzana, Manuela Mauro, Francesca Dumas, Antonino Fiannaca, Alfonso Urso, Vincenzo Arizza, Aiti Vizzini
The Ascidian C. robusta is a powerful model for studying innate immunity. LPS induction activates inflammatory-like reactions in the pharynx and the expression of several innate immune genes in granulocyte hemocytes such as cytokines, for instance, macrophage migration inhibitory factors (CrMifs). This leads to intracellular signaling involving the Nf-kB signaling cascade that triggers downstream pro-inflammatory gene expression. In mammals, the COP9 (Constitutive photomorphogenesis 9) signalosome (CSN) complex also results in the activation of the NF-kB pathway...
February 18, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36566672/oscsn1-regulates-the-growth-of-rice-seedlings-through-the-ga-signaling-pathway-in-blue-light
#33
JOURNAL ARTICLE
Shining Han, Yanxi Liu, Anar Bao, Hua Zeng, Guohui Huang, Min Geng, Chunyu Zhang, Qi Zhang, Jingmei Lu, Ming Wu, Liquan Guo
Blue light can regulate the photomorphogenesis of plants through blue light receptors to influence seedling growth and development. The COP9 signaling complex (CSN), a vital regulator of photomorphogenesis, is a highly conserved protein complex. CSN1 is the largest and most critical subunit in the CSN with a complex N-terminal function that supports most of the functions of CSN1 and is mainly involved in plant growth and development processes. The CSN is also required in the blue light-mediated photomorphogenesis response of seedlings...
January 2023: Journal of Plant Physiology
https://read.qxmd.com/read/36512632/csn6-mediates-nucleotide-metabolism-to-promote-tumor-development-and-chemoresistance-in-colorectal-cancer
#34
JOURNAL ARTICLE
Shaomin Zou, Baifu Qin, Ziqing Yang, Wencong Wang, Jieping Zhang, Yijing Zhang, Manqi Meng, Junyan Feng, Yunling Xie, Ling Fang, Lishi Xiao, Peng Zhang, Xiangqi Meng, Hyun Ho Choi, Weijie Wen, Qihao Pan, Bart Ghesquière, Ping Lan, Mong-Hong Lee, Lekun Fang
UNLABELLED: Metabolic reprogramming can contribute to colorectal cancer progression and therapy resistance. Identification of key regulators of colorectal cancer metabolism could provide new approaches to improve treatment and reduce recurrence. Here, we demonstrate a critical role for the COP9 signalosome subunit CSN6 in rewiring nucleotide metabolism in colorectal cancer. Transcriptomic analysis of colorectal cancer patient samples revealed a correlation between CSN6 expression and purine and pyrimidine metabolism...
February 3, 2023: Cancer Research
https://read.qxmd.com/read/36451342/the-cops3-foxo3-positive-feedback-loop-regulates-autophagy-to-promote-cisplatin-resistance-in-osteosarcoma
#35
JOURNAL ARTICLE
Jianfang Niu, Taiqiang Yan, Wei Guo, Wei Wang, Tingting Ren, Yi Huang, Zhiqing Zhao, Yiyang Yu, Chenglong Chen, Qingshan Huang, Jingbing Lou, Lei Guo
Chemotherapy is an important treatment modality for osteosarcoma (OS), but the development of chemoresistance limits the therapeutic efficacy of OS and results in a poor prognosis. Thus, a better understanding of the mechanisms underlying chemoresistance in OS is essential. We previously demonstrated that COPS3/CSN3 (COP9 signalosome subunit 3) functions as an oncogene to promote OS cells lung metastasis, which is closely related to chemoresistance. Here, we showed that COPS3 was significantly upregulated in OS tissues with poor response to preoperative chemotherapy...
November 30, 2022: Autophagy
https://read.qxmd.com/read/36445131/a-subunit-of-the-cop9-signalosome-mocsn6-is-involved-in-fungal-development-pathogenicity-and-autophagy-in-rice-blast-fungus
#36
JOURNAL ARTICLE
Zi-Fang Shen, Lin Li, Jing-Yi Wang, Yun-Ran Zhang, Zi-He Wang, Shuang Liang, Xue-Ming Zhu, Jian-Ping Lu, Fu-Cheng Lin, Xiao-Hong Liu
The COP9 signalosome (CSN) is a highly conserved protein complex in eukaryotes, affecting various development and signaling processes. To date, the biological functions of the COP9 signalosome and its subunits have not been determined in Magnaporthe oryzae. In this study, we characterized the CSN in M. oryzae (which we named MoCsn6) and analyzed its biological functions. MoCsn6 is involved in fungal development, autophagy, and plant pathogenicity. Compared with the wild-type strain 70-15, Δ Mocsn6 mutants showed a significantly reduced growth rate, sporulation rate, and germ tube germination rate...
November 29, 2022: Microbiology Spectrum
https://read.qxmd.com/read/36423380/differential-dynamics-of-cullin-deneddylation-via-cop9-signalosome-subunit-5-interaction
#37
JOURNAL ARTICLE
Yeong-Mu Kim, Hye-Ji Kim, Dong-Kyu Kim, Dong-Hyun Jung, Hyo Je Cho, Sangjune Kim, Jihoon Nah, Sang-Min Jang
Cullin-RING E3 ubiquitin ligases (CRLs) spatiotemporally regulate the proteasomal degradation of numerous cellular proteins involved in cell cycle control, DNA replication, and maintenance of genome stability. Activation of CRLs is controlled via neddylation by NEDD8-activating, -conjugating, and -attaching enzymes to the C-terminus of scaffold cullins (CULs), whereas the COP9 signalosome (CSN) inactivates CRLs via deneddylation. Here, we show that the deneddylation rate of each CUL is differentially modulated...
November 16, 2022: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/36181988/genome-wide-analysis-of-the-csn-genes-in-land-plants-and-their-expression-under-various-abiotic-stress-and-phytohormone-conditions-in-rice
#38
JOURNAL ARTICLE
Bozhang Shi, Jiaqi Hou, Jin Yang, Il-Jin Han, Daoyi Tu, Shiqi Ye, Jinfu Yu, Lijia Li
The CONSTITUTIVE PHOTOMORPHOGENIC9 (COP9) signalosome (CSN) is a multi-functional protein complex, which is involved in plant growth and abiotic stress response. However, the evolution and function of the CSN genes in land plants are still largely unclear. Here, we have identified 124 CSN genes and constructed phylogenetic trees of these CSN proteins to elucidate their feature and evolution in twelve land plants. Analysis of gene structure, protein property and protein motif composition shows the evolutional conservation and variation of the CSN proteins in land plants...
September 28, 2022: Gene
https://read.qxmd.com/read/36142356/fgcsn12-is-involved-in-the-regulation-of-ascosporogenesis-in-the-wheat-scab-fungus-fusarium-graminearum
#39
JOURNAL ARTICLE
Hang Jiang, Yuhan Zhang, Wanshan Wang, Xinyu Cao, Huaijian Xu, Huiquan Liu, Junshan Qi, Cong Jiang, Chenfang Wang
Fusarium head blight (FHB), caused by the fungal pathogen Fusarium graminearum , is a destructive disease worldwide. Ascospores are the primary inoculum of F. graminearum , and sexual reproduction is a critical step in its infection cycle. In this study, we characterized the functions of FgCsn12. Although the ortholog of FgCsn12 in budding yeast was reported to have a direct interaction with Csn5, which served as the core subunit of the COP9 signalosome, the interaction between FgCsn12 and FgCsn5 was not detected through the yeast two-hybrid assay...
September 9, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36135183/cops5-conferred-the-platinum-resistance-in-epithelial-ovarian-cancer
#40
JOURNAL ARTICLE
Hongqin Zhang, Tianqing Yan, Ailing Zhong, Lin Guo, Renquan Lu
Development of platinum resistance is one of the major causes of epithelial ovarian cancer (EOC) treatment failure. COP9 signalosome subunit 5 (COPS5) was found to take part in the progression of EOC in our previous study. Herein, we aim to uncover the potential utility of COPS5 in EOC chemoresistance. COPS5 levels were analyzed to define clinic pathologic correlates using a matched tissue microarray and online datasets. The effect of COPS5 inhibition by the lentivirus-mediated short hairpin RNA on cell viability, proliferation and migration was accessed in vitro and in vivo...
September 1, 2022: Current Issues in Molecular Biology
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