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https://www.readbyqxmd.com/read/28811236/interleukin-26-is-overexpressed-in-beh%C3%A3-et-s-disease-and-enhances-th17-related-cytokines
#1
Wajih Kaabachi, Eya Bouali, Anissa Berraïes, Imen Ben Dhifallh, Besma Hamdi, Kamel Hamzaoui, Agnès Hamzaoui
Behçet's disease (BD) is a multi-systemic inflammatory disorder characterized by the "triple symptom complex". Several pro-inflammatory cytokines, mainly derived from the immune Th17 axis, seem to be involved in different pathogenic pathways leading to development of the clinical manifestations. Here, we have analyzed the expression and role of IL-26 in active BD patients, an inflammatory disorder characterized by bronchoalveolar lavage fluid (BAL) and in cerebrospinal fluid (CSF) inflammation. On this basis, the primary aim of our work was to study IL-26 levels in serum, BAL CSF) from active BD patients...
August 12, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28810335/-expression-of-il-37-in-peripheral-blood-of-adults-with-primary-immune-thrombocytopenia
#2
L Liu, K Feng, M L Wang, X H Shu, K S Zhou, H Zhou, X J Liu, Y P Song
No abstract text is available yet for this article.
July 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28798075/cytokines-of-the-il-1-family-recognized-targets-in-chronic-inflammation-underrated-in-organ-transplantations
#3
REVIEW
Ilja Striz
Interleukin 1 (IL-1) family is a group of cytokines with multiple local and systemic effects, which regulates both innate and adaptive immune responses. Generally, most IL-1 family cytokines express prevailing pro-inflammatory activities (IL-1α, IL-1β, IL-18, IL-33, IL-36 α, β, γ), whereas others are anti-inflammatory (IL-1Ra (IL-1 receptor antagonist), IL-36Ra, IL-38, IL-37). In addition to their immunomodulatory roles, some of them are also involved in the physiological modulation of homeostatic processes and directly affect mRNA transcription...
September 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28792474/the-effects-of-selective-hematopoietic-expression-of-human-il-37-on-systemic-inflammation-and-atherosclerosis-in-ldlr-deficient-mice
#4
Geerte Hoeke, P Padmini S J Khedoe, Janna A van Diepen, Karin Pike-Overzet, Britt van de Ven, Nadia Vazirpanah, Isabel Mol, Pieter S Hiemstra, Frank J T Staal, Rinke Stienstra, Mihai G Netea, Charles A Dinarello, Patrick C N Rensen, Jimmy F P Berbée
The human cytokine interleukin (IL)-37 has potent anti-inflammatory capacities, and hematopoietic cell-specific transgenic overexpression of IL-37 in mice protects against septic shock and colitis. In the present study we investigated the effect of hematopoietic expression of IL-37 on atherosclerosis development under low-grade inflammatory conditions. Low-density lipoprotein receptor (LDLr)-deficient mice were lethally irradiated and transplanted with bone marrow from IL-37-transgenic or control wild-type mice and fed a Western-type diet (WTD; 1% cholesterol) for eight weeks...
August 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28783685/homodimerization-attenuates-the-anti-inflammatory-activity-of-interleukin-37
#5
Andrew M Ellisdon, Claudia A Nold-Petry, Laura D'Andrea, Steven X Cho, Jason C Lao, Ina Rudloff, Devi Ngo, Camden Y Lo, Tatiana P Soares da Costa, Matthew A Perugini, Paul J Conroy, James C Whisstock, Marcel F Nold
Dysregulation of the inflammatory response underlies numerous diseases. Although most interleukin-1 family cytokines are proinflammatory, human interleukin-37 (IL-37) is a powerful, broad-spectrum inhibitor of inflammation and immunity. We determined the crystal structure of IL-37 to establish the anti-inflammatory mechanism of this key cytokine in view of developing IL-37-based therapies. We found that two β-trefoil fold IL-37 molecules form a head-to-head dimer that is stable in solution. IL-37 variants mutated to convert the cytokine into an obligate monomer were up to 13-fold more effective than the dimer in suppressing proinflammatory events both in primary human blood cells and in vivo in murine endotoxic shock...
February 10, 2017: Science Immunology
https://www.readbyqxmd.com/read/28762845/decreased-expression-of-interleukin-37-in-the-ectopic-and-eutopic-endometria-of-patients-with-adenomyosis
#6
Jian Fa Jiang, Song Shu Xiao, Min Xue
Previous studies have shown that alterations of cytokines might play a role in the pathogenesis of adenomyosis. This study aims to investigate the expression of interleukin-37 (IL-37), an anti-inflammatory cytokine, in the eutopic and ectopic endometria of patients with adenomyosis. Endometrial specimens were collected from 30 women with adenomyosis and 20 without adenomyosis. The gene and protein expression of IL-37 was measured using a quantitative real-time polymerase chain reaction and immunohistochemistry, respectively...
August 1, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28748328/potential-therapeutic-use-of-il-37-a-key-suppressor-of-innate-immunity-and-allergic-immune-responses-mediated-by-mast-cells
#7
REVIEW
Pio Conti, Francesco Carinci, Gianfranco Lessiani, Enrico Spinas, Spyridon K Kritas, Gianpaolo Ronconi, Alessandro Caraffa, Theoharis C Theoharides
The host response to either exogenous or endogenous insults produces a series of changes, characterized by alterations in immunological functions and generation of mediators called cytokines which include the interleukin-1 (IL-1) family members. IL-1 acts as a hormone mediating the host responses to infection and inflammation. Blocking inflammatory IL-1 family members can be effective against inflammatory disorders, including allergies. IL-37, (formerly IL-1 family member 7), emerges as an inhibitor of innate and adaptive immunity by reducing circulating and organ cytokine levels...
July 26, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28733640/interleukin-37-promotes-angiogenesis-through-tgf-%C3%AE-signaling
#8
Mengmeng Zhao, Yongguang Hu, Jiayi Jin, Ying Yu, Shanshan Zhang, Jingjing Cao, Yuanfen Zhai, Rongbin Wei, Juanjuan Shou, Wenping Cai, Shangfeng Liu, Xiaoping Yang, Guo-Tong Xu, Jianhua Yang, David B Corry, Shao Bo Su, Xialin Liu, Tianshu Yang
IL-37 is a novel pro-angiogenic cytokine that potently promotes endothelial cell activation and pathological angiogenesis in our previous study, but the mechanisms behind the pro-angiogenic effect of IL-37 are less well understood. Extending our observations, we found that TGF-β interacts with IL-37, and potently enhances the binding affinity of IL-37 to the ALK1 receptor complex, thus allowing IL-37 to signal through ALK1 to activate pro-angiogenic responses. We further show that TGF-β and ALK1 are required in IL-37 induced pro-angiogenic response in ECs and in the mouse model of Matrigel plug and oxygen-induced retinopathy...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699819/targeting-cytokines-in-asthma-therapy-could-il-37-be-a-solution
#9
Michael Wegmann
No abstract text is available yet for this article.
July 17, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28685525/mast-cell-pro-inflammatory-and-anti-inflammatory-jekyll-and-hyde-the-story-continues
#10
REVIEW
P Conti, Al Caraffa, S K Kritas, G Ronconi, G Lessiani, E Toniato, T C Theoharides
IL-1 family members include inflammatory and anti-inflammatory cytokines. They can be beneficial or detrimental, not only in cancer, but also in inflammatory conditions. Mast cells (MCs) originate from CD34+/CD117+/CD13+ pluripotent hematopoietic stem cells, express c-Kit receptor (c-Kit-R), which regulates the proliferation and sustain the survival, differentiation and maturation of MCs. They are immune cells involved in innate and adaptive immunity, allergy, autoimmunity, cancer and inflammation. MCs along with T cells and macrophages release interleukin (IL)-10, which is a pleiotropic immunoregulatory cytokine with multiple biological effects...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28630603/elevated-il-37-levels-in-the-plasma-of-patients-with-severe-coronary-artery-calcification
#11
Meng Chai, Hai-Tao Zhang, Yu-Jie Zhou, Qing-Wei Ji, Qing Yang, Yu-Yang Liu, Ying-Xin Zhao, Dong-Mei Shi, Wei Liu, Li-Xia Yang, Lin-Lin Zhang, Jing Liang
BACKGROUND: Coronary artery calcification (CAC) is a predictor of cardiovascular events and plaque burden and is closely associated with chronic inflammation. Interleukin (IL)-37 is a newly discovered member of the IL-1 family and is considered an anti-inflammatory cytokine. Our recent study on mice indicated that IL-37 could attenuate atherosclerosis and vascular calcification, which suggests that IL-37 could be associated with the development of atherosclerosis and related diseases...
May 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28627005/serum-interleukin-37-a-new-player-in-lupus-nephritis
#12
Marwa G Tawfik, Samah I Nasef, Hanan H Omar, Mona S Ghaly
INTRODUCTION: Interleukin-37 (IL-37) has been proved to be a fundamental natural suppressor of innate immunity and inflammatory responses in autoimmune diseases such as systemic lupus erythematous (SLE). The purpose of this study was to assess serum IL-37 level in SLE patients and its correlation with disease activity and clinical and laboratory manifestations of SLE patients. PATIENTS/METHODS: The serum level of IL-37 was assessed and analyzed in 100 SLE patients and 50 healthy controls by using enzyme-linked immunosorbent assay (ELISA)...
June 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28607385/exogenous-interleukin-37-ameliorates-atherosclerosis-via-inducing-the-treg-response-in-apoe-deficient-mice
#13
Qingwei Ji, Kai Meng, Kunwu Yu, Song Huang, Ying Huang, Xiaohong Min, Yucheng Zhong, Bangwei Wu, Yuzhou Liu, Shaoping Nie, Jianwei Zhang, Yujie Zhou, Qiutang Zeng
Our previous study indicated that interleukin (IL)-37 is involved in atherosclerosis. In the present study, Anterior tibial arteries were collected from diabetes patients and controls. A histopathological analysis showed that IL-37 was over-expressed in human atherosclerotic plaques. Many types of cells including macrophages, vascular smooth muscle cells (VSMCs), endothelial cells and T lymphocyte expressed IL-37 in human atherosclerotic plaques. ApoE-/- mice were divided into a control group and a recombinant human IL-37-treated group...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28601872/il-37-causes-excessive-inflammation-and-tissue-damage-in-murine-pneumococcal-pneumonia
#14
Anja E Schauer, Tilman E Klassert, Carolin von Lachner, Diana Riebold, Anne Schneeweiß, Magdalena Stock, Mario M Müller, Sven Hammerschmidt, Philip Bufler, Ulrike Seifert, Kristina Dietert, Charles A Dinarello, Marcel F Nold, Achim D Gruber, Claudia A Nold-Petry, Hortense Slevogt
Streptococcus pneumoniae infections can lead to severe complications with excessive immune activation and tissue damage. Interleukin-37 (IL-37) has gained importance as a suppressor of innate and acquired immunity, and its effects have been therapeutic as they prevent tissue damage in autoimmune and inflammatory diseases. By using RAW macrophages, stably transfected with human IL-37, we showed a 70% decrease in the cytokine levels of IL-6, TNF-α, and IL-1β, and a 2.2-fold reduction of the intracellular killing capacity of internalized pneumococci in response to pneumococcal infection...
2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28548248/the-emerging-role-of-interleukin-37-in-cardiovascular-diseases
#15
REVIEW
Xinyu Zhuang, Bangwei Wu, Jian Li, Haiming Shi, Bo Jin, Xinping Luo
INTRODUCTION: Interleukin (IL)-37 is a newly identified member of the IL-1 family, and shows a growing role in a variety of diseases. This review aims at summarizing and discussing the role of IL-37 in cardiovascular diseases. METHODS: Data for this review were identified by searches of MEDLINE, Embase, and PubMed using appropriate search terms. RESULTS: IL-37 is a newly identified cytokine belonging to the IL-1 family and is expressed in inflammatory immune cells and several parenchymal cells...
May 26, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28467774/interleukin-37-mediates-the-antitumor-activity-in-colon-cancer-through-%C3%AE-catenin-suppression
#16
Xiaofei Yan, Jian Zhao, Rui Zhang
The occurrence and development of colon cancer is closely related to inflammation. Thus, we conducted the present retrospective study to investigate the effects of IL-37 (Interleukin 37), a newly identified anti-inflammatory factor, on colon cancer development. We first evaluated the IL-37 expression in 186 pairs of colon cancer samples and their adjacent normal mucosa by real-time PCR, ELISA (Enzyme-linked immunoassay) and tissue microarrays. Then the role of IL-37 on patient survival rates, colon cancer progression and their sensitivity to chemotherapy drugs were assessed...
July 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28433890/il-37-induces-autophagy-in-hepatocellular-carcinoma-cells-by-inhibiting-the-pi3k-akt-mtor-pathway
#17
Ting-Ting Li, Di Zhu, Tong Mou, Zhen Guo, Jun-Liang Pu, Qing-Song Chen, Xu-Fu Wei, Zhong-Jun Wu
Autophagy is an intracellular "self-eating" process that is closely related to inflammation and cellular immunity. New studies indicate that autophagy is also involved in tumor suppression. The anti-inflammatory cytokine interleukin-37 (IL-37) has been shown to have tumor-suppressive abilities in hepatocellular carcinoma (HCC). Notably, autophagy appears to play a dual role in the development of HCC and may be involved in both tumorigenesis and tumor suppression. However, the potential role of IL-37 in autophagy is currently unknown...
April 20, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28420489/mast-cells-emerge-as-mediators-of-atherosclerosis-special-emphasis-on-il-37-inhibition
#18
REVIEW
Pio Conti, Gianfranco Lessiani, Spyridon K Kritas, Gianpaolo Ronconi, Aessandro Caraffa, Theoharis C Theoharides
In atherosclerosis lipoproteins stimulate the innate immune response, leading to the release of inflammatory cytokines and chemokines. Hypercholesterolemia may activate the synthesis and release of inflammatory cytokines such as IL-1, which induces TNF release in mast cells (MCs). IL-1 and IL-1 family members orchestrate a broadening list of inflammatory diseases, including atherosclerosis. MCs are implicated in the pathophysiology of several diseases including allergy and inflammation. Activated MCs, located perivascularly, contribute to inflammation in atherosclerosis by producing inflammatory cytokines...
June 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28415700/circulating-tumor-cells-promote-the-metastatic-colonization-of-disseminated-carcinoma-cells-by-inducing-systemic-inflammation
#19
Yong-Chao Li, Jiu-Ming Zou, Chao Luo, Yu Shu, Jing Luo, Jian Qin, Yu Wang, Dong Li, Shan-Shan Wang, Gang Chi, Fang Guo, Gui-Mei Zhang, Zuo-Hua Feng
Circulating tumor cells (CTCs) have been studied well in the prognosis for malignant diseases as liquid biopsy, but their contribution to tumor metastasis is not clearly defined. Here we report that CTCs could promote the metastatic colonization of disseminated carcinoma cells by inducing systemic inflammation and neutrophil recruitment to pre-metastatic organs. Depletion of neutrophils in vivo could effectively abrogate the promoting effect of CTCs on tumor cell metastasis. In the presence of CTCs, the pro-tumor function of neutrophils was augmented, whereas the antitumor function of neutrophils was suppressed...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28395710/-interleukin-37-induces-apoptosis-and-autophagy-of-smmc-7721-cells-by-inhibiting-phosphorylation-of-mtor
#20
Tingting Li, Di Zhu, Tong Mou, Zhen Guo, Junliang Pu, Zhongjun Wu
Objective To investigate the underlying mechanism by which interleukin-37 (IL-37) induces the apoptosis and autophagy in SMMC-7721 cells. Methods SMMC-7721 cells were incubated in vitro and divided into two groups, IL-37 treated group and control group. The cells were treated with (50, 100, 200) ng/mL of recombinant human interleukin-37 (rhIL-37). CCK-8 assay was used to detect the cell proliferation of SMMC-7721 cells. Cell apoptosis was measured by flow cytometry. Western blot analysis was performed to examine the expressions of apoptosis-related proteins, Bax, Bcl-2, and autophagy related proteins, microtubule-associated proteins 1 light chain 3 (LC3), beclin 1 and mammalian target of rapamycin (mTOR)...
April 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
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