keyword
MENU ▼
Read by QxMD icon Read
search

IL-37

keyword
https://www.readbyqxmd.com/read/29784636/adaptive-nk-cells-resist-regulatory-t-cell-suppression-driven-by-il-37
#1
Dhifaf Sarhan, Keli L Hippen, Amanda Lemire, Skyler Hying, Xianghua Luo, Todd Lenvik, Julie Curtsinger, Zachary Davis, Bin Zhang, Sarah Cooley, Frank Cichocki, Bruce R Blazar, Jeffrey S Miller
Natural Killer (NK) cells are capable of fighting viral infections and cancer. However, these responses are inhibited by immune suppressor cells in the tumor microenvironment. Tumor progression promotes the recruitment and generation of intratumoral regulatory T cells (Tregs), associated with a poor prognosis in cancer patients. Here, we show that canonical NK cells are highly susceptible to Treg-mediated suppression, in contrast to highly resistant CD57+ FcεRγ-NKG2C+ adaptive (CD56+CD3-) NK cells that expand in cytomegalovirus (CMV)-exposed individuals...
May 21, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29757591/evaluating-serum-levels-of-il-33-il-36-il-37-and-gene-expression-of-il-37-in-patients-with-psoriasis-vulgaris
#2
Mojtaba Sehat, Rezvan Talaei, Ehsan Dadgostar, Hassan Nikoueinejad, Hossein Akbari
Serum levels of interleukin (IL)-33, IL-36 and IL-37 have been reported to be up-regulated in various T helper (Th)1/Th17 mediated autoimmune/inflammatory diseases. Although IL-33 and IL-36 expression are increased in skin lesions of patients with psoriasis, their serum levels in such patients have not yet been adequately studied. We aimed to evaluate serum level of IL-33, IL-36 and IL-37 cytokines and IL-37 gene expression in patients with autoimmune/inflammatory disease of psoriasis and to explore their correlation with disease severity...
April 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29730558/increased-expression-of-il-1r8-and-a-possible-immunomodulatory-role-of-its-ligand-il-37-in-allergic-rhinitis-patients
#3
Cong Li, Yang Shen, Jue Wang, Zu-Xia Ma, Xia Ke, Zhi-Hai Wang, Su-Ling Hong, Guo-Hua Hu
Allergic rhinitis (AR) is a chronic inflammatory airway disease that is caused by an abnormal T cell response. T helper (Th)-17 cells and Th2 cells are the CD4+ T cell subsets implicated in the pathogenesis of AR. The suppression of excessive responses of these Th17 and Th2 cells has been reported to be an effective therapeutic approach to treat AR patients, and continuous efforts are being undertaken to find new methods to modulate the function of these cells. Recent studies have shown that IL-1R8 and its ligand IL-37 negatively regulate the immune response...
May 3, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29685013/status-of-cathelicidin-il-37-cytokine-tnf-and-vitamin-d-in-patients-with-pulmonary-tuberculosis
#4
K Majewski, J Agier, E Kozłowska, E Brzezińska-Błaszczyk
Development of Mycobacterium tuberculosis (Mtb) infection depends on the ability of the host to elicit the protective immune response to the pathogen. Cathelicidin plays a role in antibacterial innate immunity mechanisms. This peptide contributes to the barrier function of respiratory epithelium and takes part in controlling pulmonary bacterial infections. LL-37 (leucine-leucine-37) is involved in host defense and innate immune response to mycobacterial infections, as well. This study aims to evaluate the serum concentrations of LL-37 in individuals with active pulmonary tuberculosis (TB) and to determine whether any correlations between peptide LL-37, tumor necrosis factor (TNF) and vitamin D serum levels exist...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29684996/low-grade-chronic-inflammation-mediated-by-mast-cells-in-fibromyalgia-role-of-il-37
#5
F Mastrangelo, I Frydas, G Ronconi, S K Kritas, L Tettamanti, Al Caraffa, C D Ovidio, A Younes, C E Gallenga, P Conti
It has been observed that acute stress causes the activation of TH1 cells, while TH2 cells regulate and act on chronic inflammation. Fibromyalgia (FM) is a chronic, idiopathic disorder which affects about twelve million people in the United States. FM is characterized by chronic widespread pain, fatigue, aching, joint stiffness, depression, cognitive dysfunction and non-restorative sleep. The mechanism of induction of muscle pain and inflammation is not yet clear. In FM there is an increase in reactivity of central neurons with increased sensitivity localized mainly in the CNS...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29683837/role-of-interleukin-37-as-a-novel-proangiogenic-factor-in-juvenile-idiopathic-arthritis
#6
Amal Mohamad El-Barbary, Manal Shawky Hussein, Samah Hamdy Almedany, Elsayed Mohamad Rageh, Alaa Mohamed Alsalawy, Marwa Ahmed Aboelhawa, Radwa Mostafa Elkholy, Noha Mohamed Shafik, Ahmed Shukry Elharoun
OBJECTIVE: The aim of this study was to investigate interleukin 37 (IL-37) levels in the serum and synovial fluid of patients with juvenile idiopathic arthritis (JIA), its expression in peripheral blood mononuclear cells, and correlation with disease activity and angiogenesis. METHODS: Seventy JIA patients and 50 control subjects were examined. The Juvenile Arthritis Disease Activity Score in 27 joints (JADAS-27) was calculated. Immunoassays were used to measure the serum and synovial fluid levels of IL-37, vascular endothelial growth factor (VEGF), soluble VEGF receptor 1 (sVEGF-R1), and sVEGF-R2...
April 16, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29575809/il-37-inhibits-invasion-and-metastasis-in-non-small-cell-lung-cancer-by-suppressing-the-il-6-stat3-signaling-pathway
#7
Mingfang Jiang, Ye Wang, Hua Zhang, Youxin Ji, Peng Zhao, Rongli Sun, Chunling Zhang
BACKGROUND: IL-37 has been identified as a fundamental inhibitor of inflammatory and immunity responses. It plays a crucial protective role in several cancers, but its anti-tumor activity and the potential regulatory mechanism of IL-37 in non-small cell lung cancer (NSCLC) is largely unclear. METHODS: Enzyme-linked immunosorbent assay was used to detect plasma IL-37 expression in NSCLC patients and healthy controls. The NSCLC cell line A549 was cultured with recombinant human IL-37 or recombinant human IL-6 protein...
March 25, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29566725/interleukin-37-is-increased-in-adult-onset-still-s-disease-and-associated-with-disease-activity
#8
Huihui Chi, Dongzhou Liu, Yue Sun, Qiongyi Hu, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Yufeng Yin, Mengru Liu, Xinyao Wu, Zhuochao Zhou, Jialin Teng, Chengde Yang, Yutong Su
BACKGROUND: Interleukin (IL)-37 has been known to play an immunosuppressive role in various inflammatory disorders, but whether it participates in the regulation of pathogenesis of adult-onset Still's disease (AOSD) has not been investigated. In this study, we examined serum IL-37 levels and their clinical association with AOSD, and we explored the anti-inflammatory effects of IL-37 on peripheral blood mononuclear cells (PBMCs) from patients with AOSD. METHODS: Blood samples were collected from 62 patients with AOSD and 50 healthy control subjects (HC)...
March 22, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29552110/interleukin-37-a-crucial-cytokine-with-multiple-roles-in-disease-and-potentially-clinical-therapy
#9
Lijuan Wang, Yanchun Quan, Yongfang Yue, Xueyuan Heng, Fengyuan Che
Interleukin (IL)-37, a new IL-1 family member, has received increasing attention in recent years. In the past decade, it has been determined that IL-37 is expressed in various normal cells and tissues and is regulated by inflammatory stimuli and pro-cytokines via different signal transduction pathways. Recently, it has been found that IL-37 is expressed in a variety of cancers, chronic inflammatory and autoimmune disorders, and exerts anti-inflammatory effects. Moreover, a growing body of literature demonstrates that IL-37 plays a vital role in inhibiting both innate and adaptive immune responses as well as inflammatory reactions...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29500054/elevated-frequency-of-il-37-and-il-18r%C3%AE-positive-t-cells-in-the-peripheral-blood-of-rheumatoid-arthritis-patients
#10
Liuqing Wang, Yueying Wang, Liping Xia, Hui Shen, Jing Lu
OBJECTIVE: To detect the expression of IL-37 and its receptors IL-18Rα and IL-1R8 in CD4+ T cells and total lymphocytes in rheumatoid arthritis (RA) patients and the relationship between autoantibodies and disease activity. To investigate the mechanism of IL-37 and its receptors involved in the pathogenesis of RA. To evaluate the effects of different concentrations of rhIL-37 on peripheral blood mononuclear cells (PBMCs) in RA patients with TNF-α, and IL-6. METHODS: The expression of IL-37 and its receptor IL-18Rα and IL-1R8 in peripheral blood CD4+ T cells and total lymphocytes in RA patients and healthy controls were measured by flow cytometry...
February 28, 2018: Cytokine
https://www.readbyqxmd.com/read/29439249/transgenic-overexpression-of-il-37-protects-against-atherosclerosis-and-strengthens-plaque-stability
#11
Jing Liu, Jibin Lin, Shaolin He, Chun Wu, Boyuan Wang, Jie Liu, Yanping Duan, Tianxiao Liu, Shengshuai Shan, Keping Yang, Nianguo Dong, Qingwei Ji, Kai Huang, Dazhu Li
BACKGROUND/AIMS: Recently, studies have shown that interleukin-37 (IL-37) is involved in atherosclerosis-related diseases. However, the regulatory mechanisms of IL-37 in atherosclerosis remain unknown. This study aims to determine the role of IL-37 in atherosclerosis and to investigate the underlying mechanisms involved. METHODS: IL-37 expression in human atherosclerotic plaques was detected by immunohistochemical staining and real-time reverse transcription polymerase chain reaction (RT-PCR)...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29424310/elevated-interleukin-37-expression-associated-with-disease-activity-in-hla-b27-associated-anterior-uveitis-and-idiopathic-anterior-uveitis
#12
B Zhao, S Zhang, W Chen, R Zhang, R Jiang, R Zhang, L Chen
BACKGROUND & OBJECTIVE: Interleukin 37 (IL-37) is an important regulator of the anti-inflammatory T-cell response. In this study, we investigated its expression and function in peripheral blood mononuclear cells (PBMCs) of patients with HLA-B27 associated acute anterior uveitis (AAU) and idiopathic AAU. METHODS: 15 patients with HLA-B27-associated AAU, 10 patients with idiopathic AAU and 22 controls were recruited to this study from August 2013 to December 2016...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29344110/anti-interleukin-and-interleukin-therapies-for-psoriasis-current-evidence-and-clinical-usefulness
#13
REVIEW
Ya-Chu Tsai, Tsen-Fang Tsai
Anti-interleukin (IL) therapies have emerged as a major treatment for patients with moderate-to-severe psoriasis. This article reviews the up-to-date results of pivotal clinical trials targeting the interleukins used for the treatment of psoriasis, including IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, IL-17, IL-20, IL-22, IL-23, IL-36 and bispecific biologics IL-17A/tumor necrosis factor alpha (TNF-α). Cytokines involved in the circuits of psoriasis inflammation without ongoing clinical trials are also mentioned (IL-9, IL-13, IL-15, IL-16, IL-18, IL-19, IL-21, IL-24, IL-27, IL-33, IL-35, IL-37, and IL-38)...
November 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/29336365/-il1f7-gene-polymorphism-is-not-associated-with-rheumatoid-arthritis-susceptibility-in-the-northern-chinese-han-population-a-case-control-study
#14
Xiao-Ying Zhang, Yu Zuo, Chun Li, Xin Tu, Hu-Ji Xu, Jian-Ping Guo, Zhan-Guo Li, Rong Mu
BACKGROUND: Interleukin (IL)-37, also called IL1F7, is a natural inhibitor of inflammatory and immune responses. It is involved in the pathogenesis of rheumatoid arthritis (RA). This study aimed to investigate the role of IL1F7 gene polymorphism in RA susceptibility in a large cohort of patients. METHODS: Five selected single-nucleotide polymorphisms in IL1F7 genes (rs2723186, rs3811046, rs4241122, rs4364030, and rs4392270) were genotyped by TaqMan Allelic Discrimination in Northern Chinese Han population...
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29319845/il-37-inhibits-il-4-il-13-induced-ccl11-production-and-lung-eosinophilia-in-murine-allergic-asthma
#15
J Lv, Y Xiong, W Li, X Cui, X Cheng, Q Leng, R He
BACKGROUND: IL-37 is emerging as an anti-inflammatory cytokine, particularly in innate inflammation. However, the role of IL-37 in Th2-mediated allergic lung inflammation remains uncertain. We sought to determine the role and the underlying mechanisms of IL-37 in the development of house dust mites (HDM)-induced murine asthma model. METHODS: We examined the effect of IL-37 administration during the sensitization or challenge phase on Th2-mediated allergic asthma induced by inhaled HDM...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29278881/effects-of-exogenous-il-37-on-the-biological-characteristics-of-human-lung-adenocarcinoma-a549-cells-and-the-chemotaxis-of-regulatory-t-cells
#16
Yu-Hua Chen, Bi-Yun Zhou, Guo-Cai Wu, De-Quan Liao, Jing Li, Si-Si Liang, Xian-Jin Wu, Jun-Fa Xu, Yong-Hua Chen, Xiao-Qing Di, Qiong-Yan Lin
BACKGROUND: This study aims to investigate the effects of exogenous interleukin (IL)-37 on the biological characteristics of human lung adenocarcinoma A549 cells and the chemotaxis of regulatory T (Treg) cells. METHODS: After isolating the CD4+ CD25+ Treg cells from the peripheral blood, flow cytometry was used to detect the purity of the Treg cells. A549 cells were divided into blank (no transfection), empty plasmid (transfection with pIRES2-EGFP empty plasmid) or IL-37 group (transfection with pIRES2-EGFP-IL-37 plasmid)...
February 14, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29247996/il-1-and-il-1-regulatory-pathways-in-cancer-progression-and-therapy
#17
REVIEW
Alberto Mantovani, Isabella Barajon, Cecilia Garlanda
Inflammation is an important component of the tumor microenvironment. IL-1 is an inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL-1 is subject to regulation by components of the IL-1 and IL-1 receptor (ILR) families. Negative regulators include a decoy receptor (IL-1R2), receptor antagonists (IL-1Ra), IL-1R8, and anti-inflammatory IL-37. IL-1 acts at different levels in tumor initiation and progression, including driving chronic non-resolving inflammation, tumor angiogenesis, activation of the IL-17 pathway, induction of myeloid-derived suppressor cells (MDSC) and macrophage recruitment, invasion and metastasis...
January 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29247989/tuning-inflammation-and-immunity-by-the-negative-regulators-il-1r2-and-il-1r8
#18
REVIEW
Martina Molgora, Domenico Supino, Alberto Mantovani, Cecilia Garlanda
Interleukin-1 receptor family members (ILRs) and Toll-Like Receptors (TLRs) are key players in immunity and inflammation and are tightly regulated at different levels. Most cell types, including cells of the innate and adaptive immune system express ILRs and TLRs. In addition, IL-1 family members are emerging as key players in the differentiation and function of innate and adaptive lymphoid cells. IL-1R2 and IL-1R8 (also known as TIR8 or SIGIRR) are members of the ILR family acting as negative regulators of the IL-1 system...
January 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29247988/interleukin-18-biological-properties-and-role-in-disease-pathogenesis
#19
REVIEW
Gilles Kaplanski
Initially described as an interferon (IFN)γ-inducing factor, interleukin (IL)-18 is indeed involved in Th1 and NK cell activation, but also in Th2, IL-17-producing γδ T cells and macrophage activation. IL-18, a member of the IL-1 family, is similar to IL-1β for being processed by caspase 1 to an 18 kDa-biologically active mature form. IL-18 binds to its specific receptor (IL-18Rα, also known as IL-1R7) forming a low affinity ligand chain. This is followed by recruitment of the IL-18Rβ chain. IL-18 then uses the same signaling pathway as IL-1 to activate NF-kB and induce inflammatory mediators such as adhesion molecules, chemokines and Fas ligand...
January 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29247987/suppression-of-inflammation-and-acquired-immunity-by-il-37
#20
REVIEW
Giulio Cavalli, Charles A Dinarello
IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli. Following activating cleavage by caspase-1, mature IL-37 translocates to the nucleus, where it suppresses transcription of pro-inflammatory genes. Both precursor and mature IL-37 are also secreted in the extracellular space, where they bind IL-18Rα and recruit the IL-1R8 (formerly TIR8 or SIGIRR), which transduces anti-inflammatory signals by suppressing NF-kB and MAPK and by activating Mer-PTEN-DOK pathways...
January 2018: Immunological Reviews
keyword
keyword
67908
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"