keyword
MENU ▼
Read by QxMD icon Read
search

caspase-1

keyword
https://www.readbyqxmd.com/read/28944913/oleanolic-acid-alleviates-diabetic-rat-carotid-artery-injury-through-the-inhibition-of-nlrp3-inflammasome-signaling-pathways
#1
Qian An, Qian Hu, Bing Wang, Wenjun Cui, Fei Wu, Yu Ding
The overexpression of inflammasome components is correlated with diabetes‑associated complications. Oleanolic acid is a triterpenoid compound which is important in arterial injury. The present study evaluated whether oleanolic acid improved diabetic rat carotid artery injury through the inhibition of nucleotide‑binding domain, leucine‑rich‑containing family, pyrin domain‑containing‑3 (NLRP3) inflammasomes signaling pathways. A diabetic rat model was induced using streptozotocin (60 mg/kg) and underwent carotid artery injury...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28942141/carbon-monoxide-regulates-glycolysis-dependent-nlrp3-inflammasome-activation-in-macrophages
#2
Do Won Lee, Ha Young Shin, Ji Hun Jeong, Jaeseok Han, Seongho Ryu, Kiichi Nakahira, Jong-Seok Moon
Low dose of carbon monoxide (CO) has anti-inflammatory role through various signaling pathways. Cellular metabolism has been implicated in the activation of inflammation in immune cells. However, the mechanisms by which CO-dependent metabolic regulation affect the immune response remain unclear. Here we show that CO-dependent metabolic pathway regulates the activation of the nucleotide-binding domain, leucine-rich-repeat-containing receptor (NLR), pyrin-domain-containing 3 (NLRP3) inflammasome. CO-releasing molecule-3 (CORM-3) resulted in reduced glycolysis-dependent NLRP3 inflammasome activation in macrophages...
September 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28942022/x-11-5-27-a-daidzein-derivative-inhibits-nlrp3-inflammasome-activity-via-promoting-autophagy
#3
Wei Zhou, Xiuting Liu, Kunpeng Cheng, Xin Zhang, Jinrong Lu, Rong Hu
NLRP3 inflammasome is a cytoplasmic multiprotein complex which plays a critical role in response to infection or injury, however, aberrant NLRP3 inflammasome activation is deleterious. In our study, we investigate the inhibitory effect of X-11-5-27, a daidzein derivative, on the NLRP3 inflammasome. The results showed that the activation of NLRP3 inflammasome was inhibited by X-11-5-27 in a dose-dependent manner, followed by a decrease in the cleavage of caspase-1 and maturation of IL-1β. Furthermore, we found that X-11-5-27 significantly restrained the formation of NLRP3 inflammasome...
September 20, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28941191/activating-%C3%AE-7-nicotinic-acetylcholine-receptor-inhibits-nlrp3-inflammasome-through-regulation-of-%C3%AE-arrestin-1
#4
Ping Ke, Bo-Zong Shao, Zhe-Qi Xu, Xiong-Wen Chen, Wei Wei, Chong Liu
AIMS: To evaluate whether activating α7 nicotinic acetylcholine receptor (α7nAChR) could inhibit the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome through regulation of β-arrestin-1 in monocyte/macrophage system, thus contributing to the control of neuroinflammation. METHODS: The protein levels of NLRP3, caspase-1 (Casp-1) p20 and proCasp-1, interleukin-1β (IL-1β) p17 and proIL-1β, IL-18 and proIL-18 were measured using Western blotting...
September 21, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28940479/activation-of-the-nlrp3-inflammasome-in-microglia-the-role-of-ceramide
#5
Hannah Scheiblich, Anna Schlütter, Douglas T Golenbock, Eicke Latz, Pilar Martinez-Martinez, Michael T Heneka
Inflammation within the CNS is a major component of many neurodegenerative diseases. A characteristic feature is the generation of microglia-derived factors that play an essential role in the immune response. IL-1β is a pro-inflammatory cytokine released by activated microglia, able to exacerbate injury at elevated levels. In the presence of caspase-1, pro-IL-1β is cleaved to the mature cytokine following NLRP3 inflammasome activation. Growing evidence suggests that ceramide plays a critical role in NLRP3 inflammasome assembly, however, the relationship between ceramide and inflammasome activation in microglia remains unknown...
September 23, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28938606/oroxylin-a-inhibits-colitis-by-inactivating-nlrp3-inflammasome
#6
Wei Zhou, Xiuting Liu, Xin Zhang, Jingjing Tang, Zhiyu Li, Qing Wang, Rong Hu
NLRP3 inflammasome is a novel therapeutic target for inflammatory bowel disease (IBD). The aim of this study was to investigate the anti-inflammatory effect of a bioactive flavonoid-oroxylin A on the treatment of dextran sulfate sodium (DSS)-induced murine colitis via targeting NLRP3 inflammasome. In this study, we found that oroxylin A attenuated experimental colitis in mice, including loss of body weights, shortening of the colon lengths and infiltration of inflammatory cells. The production of IL-1β, IL-6 and TNF-α in colon was also markedly reduced by oroxylin A...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938395/aldose-reductase-mediates-nlrp3-inflammasome-initiated-innate-immune-response-in-hyperglycemia-induced-thp1-monocytes-and-male-mice
#7
Pabitra B Pal, Himangshu Sonowal, Kirtikar Shukla, Satish K Srivastava, Kota V Ramana
Despite recent studies that show oxidative stress-generated reactive oxygen species (ROS) regulate NLRP3-inflammasome-mediated innate immune response in various diabetic complications, the mechanism(s) of how ROS activate innate immune response is not well understood. We have shown earlier that aldose reductase (AR), besides reducing glucose, reduces lipid aldehydes and their glutathione conjugates and participates in various oxidative stress-induced inflammatory pathways. To understand the role of AR in ROS-induced innate immune response, we have investigated the mechanism(s) by which AR activates hyperglycemia-induced NLRP3-inflammsome- initiated innate immune response in Thp1 monocytes and in streptozotocin (STZ)-induced diabetic mice...
July 28, 2017: Endocrinology
https://www.readbyqxmd.com/read/28936769/nlrp3-inflammasome-activation-in-a-transgenic-amyotrophic-lateral-sclerosis-model
#8
Agnese Gugliandolo, Sabrina Giacoppo, Placido Bramanti, Emanuela Mazzon
Amyotrophic lateral sclerosis (ALS) is a disabling progressive disease characterized by the degeneration of motor neurons, leading to muscle atrophy and paralysis. The majority of cases are sporadic, but also a familiar form of ALS exists, and some genes causative of the pathology were found. In particular, mutations in superoxide dismutase 1 (SOD1) were found in 20% of familiar cases. It is known that neuroinflammation plays a pivotal role in several neurodegenerative disorders, including ALS. Inflammasomes are protein complexes that induce inflammation in response to various stimuli, involved also in neuroinflammation...
September 21, 2017: Inflammation
https://www.readbyqxmd.com/read/28936177/withaferin-a-induces-oxidative-stress-mediated-apoptosis-and-dna-damage-in-oral-cancer-cells
#9
Hsueh-Wei Chang, Ruei-Nian Li, Hui-Ru Wang, Jing-Ru Liu, Jen-Yang Tang, Hurng-Wern Huang, Yu-Hsuan Chan, Ching-Yu Yen
Withaferin A (WFA) is one of the most active steroidal lactones with reactive oxygen species (ROS) modulating effects against several types of cancer. ROS regulation involves selective killing. However, the anticancer and selective killing effects of WFA against oral cancer cells remain unclear. We evaluated whether the killing ability of WFA is selective, and we explored its mechanism against oral cancer cells. An MTS tetrazolium cell proliferation assay confirmed that WFA selectively killed two oral cancer cells (Ca9-22 and CAL 27) rather than normal oral cells (HGF-1)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28931603/the-pyhin-protein-p205-regulates-the-inflammasome-by-controlling-asc-expression
#10
Sreya Ghosh, Christina Wallerath, Sergio Covarrubias, Veit Hornung, Susan Carpenter, Katherine A Fitzgerald
Members of the IFN-inducible PYHIN protein family, such as absent in melanoma-2 and IFN-γ-inducible protein (IFI)16, bind dsDNA and form caspase-1-activating inflammasomes that are important in immunity to cytosolic bacteria, DNA viruses, or HIV. IFI16 has also been shown to regulate transcription of type I IFNs during HSV infection. The role of other members of the PYHIN protein family in the regulation of immune responses is much less clear. In this study, we identified an immune-regulatory function for a member of the murine PYHIN protein family, p205 (also called Ifi205)...
September 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28930866/p2x7r-blockade-prevents-nlrp3-inflammasome-activation-and-pancreatic-fibrosis-in-a-mouse-model-of-chronic-pancreatitis
#11
Gui-Xian Zhang, Man-Xue Wang, Wei Nie, Da-Wei Liu, Yi Zhang, Hong-Bin Liu
OBJECTIVES: The aim of this study was to investigate the role of P2X7R (purinergic 2X7 receptor) and NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome activation in the process of pancreatic fibrosis in a mouse model of chronic pancreatitis (CP). METHODS: Chronic pancreatitis was induced by repeated intraperitoneal injections of 50 μg/kg cerulein for 6 weeks in mice. P2X7R antagonist oxidized ATP (OxATP) or brilliant blue G (BBG) was administered after the last cerulein injection for 2 weeks...
September 19, 2017: Pancreas
https://www.readbyqxmd.com/read/28930551/uremic-toxins-are-conditional-danger-or-homeostasis-associated-molecular-patterns
#12
Yu Sun, Candice Johnson, Jun Zhou, Luqiao Wang, Ya-Feng Li, Yifan Lu, Gayani Nanayakkara, Hangfei Fu, Ying Shao, Claudette Sanchez, William Y Yang, Xin Wang, Eric T Choi, Rongshan Li, Hong Wang, Xiao-Feng Yang
We mined novel uremic toxin (UT) metabolomics/gene databases, and analyzed the expression changes of UT receptors and UT synthases in chronic kidney disease (CKD) and cardiovascular disease (CVD). We made the following observations: 1) UTs represent only 1/80(th) of human serum small-molecule metabolome; 2) Some UTs are increased in CKD and CVD; 3) UTs either induce or suppress the expression of inflammatory molecules; 4) The expression of UT genes is significantly modulated in CKD patients, and coronary artery disease (CAD) patients; 5) The expression of UT genes is upregulated by caspase-1 and TNF-alpha pathways but is inhibited in regulatory T cells...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930487/emerging-roles-of-inflammasomes-in-acute-pneumonia
#13
Sangeetha Ravi Kumar, Sagar Paudel, Laxman Ghimire, Scott Bergeron, Shanshan Cai, Rachel L Zemans, Gregory P Downey, Samithamby Jeyaseelan
Pneumonia is responsible for a substantial burden on healthcare worldwide and the single largest cause for death of infants globally. Pneumonia is caused by a variety of pathogenic microorganisms including bacteria, viruses and fungi. The lung has developed complex innate immune mechanisms to combat these infections while minimizing tissue damage. One essential mechanism that drives the initial innate immune response is sensing a broad spectrum of stimuli in the cytosol by inflammasomes. Inflammasomes are composed of NLR and non-NLR proteins, and activate caspase-1 that results in proinflammatory cytokine activation...
September 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28926719/exosomes-derived-from-embryonic-stem-cells-inhibit-doxorubicin-and-inflammation-induced-pyroptosis-in-muscle-cells
#14
Zahra Tavakoli Dargani, Reetu Singla, Taylor Johnson, Rakesh C Kukreja, Dinender Kumar Singla
Doxorubicin (Dox) is an effective anticancer drug. Unfortunately, it causes cardio and muscle toxicity due to increased oxidative stress and inflammation; however, it remains unknown whether Dox induces "pyroptosis"- an inflammation mediated cell death. We investigated whether Dox induces pyroptosis in mouse soleus muscle (Sol 8) cells in vitro and to show the protective effect of embryonic stem cells-exosomes (ES-exos) on pyroptosis. Doxorubicin and inflammation induced in vitro model was generated. Pyroptosis was confirmed using immunohistochemistry and western blotting of putative markers caspase-1, IL1β and pro-inflammatory cytokine IL-18...
September 19, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28918467/anisodamine-inhibits-endoplasmic-reticulum-stress-associated-txnip-nlrp3-inflammasome-activation-in-rhabdomyolysis-induced-acute-kidney-injury
#15
Xiaopeng Yuan, Yitao Zheng, Chuanbao Chen, Changxi Wang
Anisodamine protects against free radical-induced cellular damage. This study aimed to investigate the protective effect of anisodamine on rhabdomyolysis-induced acute kidney injury (RIAKI). C57BL/6 J mice, TXNIP(-/-) and NLRP3 (-/-) (both were C57BL/6 J background) mice were used to construct RIAKI model. Anisodamine administration was performed on RIAKI mice only. Mice were divided into control, TXNIP-KD (knock down), LNPR3-KD, and anisodamine group (n = 15 in each group). The renal injury, renal function, renal tubular cells apoptosis and expression of Caspase-1, ASC, endoplasmic reticulum (ER) stress markers IRE-1α, CHOP, and ATF4, and interleukin (IL-1α, IL-1β, and IL-18) were detected...
September 16, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28915449/increased-expression-of-nlrp3-inflammasome-in-placentas-from-pregnant-women-with-severe-preeclampsia
#16
Ingrid C Weel, Mariana Romão-Veiga, Mariana L Matias, Eduardo G Fioratti, Jose C Peraçoli, Vera T Borges, João P Araujo, Maria T Peraçoli
Preeclampsia is a pregnancy disorder characterized by imbalance between pro- and anti-inflammatory cytokines associated with high plasma levels of uric acid and Interleukin-1 beta (IL-1β). The inflammasome is a protein complex that mediates innate immune responses via caspase-1 activation promoting secretion of IL-1β and IL-18 in their active forms, and also release of the high-mobility group box 1 protein (HMGB1). As the placenta seems to play an important role in the pathogenesis of PE, the present study investigated the expression of genes and proteins related to the inflammasome in placentas from pregnant women with severe preeclampsia...
September 6, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28912259/nod2-nucleotide-binding-oligomerization-domain-2-is-a-major-pathogenic-mediator-of-coxsackievirus-b3-induced-myocarditis
#17
Carsten Tschöpe, Irene Müller, Yu Xia, Konstantinos Savvatis, Kathleen Pappritz, Sandra Pinkert, Dirk Lassner, Markus M Heimesaat, Frank Spillmann, Kapka Miteva, Stefan Bereswill, Heinz-Peter Schultheiss, Henry Fechner, Burkert Pieske, Uwe Kühl, Sophie Van Linthout
BACKGROUND: The cytoplasmatic pattern recognition receptor, NOD2 (nucleotide-binding oligomerization domain 2), belongs to the innate immune system and is among others responsible for the recognition of single-stranded RNA. With Coxsackievirus B3 (CVB3) being a single-stranded RNA virus, and the recent evidence that the NOD2 target, NLRP3 (NOD-like receptor family, pyrin domain containing 3) is of importance in the pathogenesis of CVB3-induced myocarditis, we aimed to unravel the role of NOD2 in CVB3-induced myocarditis...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28904873/a-calpain-inhibitor-protects-against-fractalkine-production-in-lipopolysaccharide-treated-endothelial-cells
#18
Jaewoong Jang, Yoosik Yoon, Dong-Jin Oh
BACKGROUND: Fractalkine (CX3CL1) is a chemokine with a unique CX3C motif and is produced by endothelial cells stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, interleukin (IL)-1, and interferon-γ. There have been several reports that the caspase/calpain system is activated in endotoxemia, which leads to cellular apoptosis and acute inflammatory processes. We aimed to determine the role of the caspase/calpain system in cell viability and regulation of fractalkine production in LPS-treated endothelial cells...
September 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28904553/manual-acupuncture-suppresses-the-expression-of-proinflammatory-proteins-associated-with-the-nlrp3-inflammasome-in-the-hippocampus-of-samp8-mice
#19
Ning Ding, Jing Jiang, Menghan Lu, Jiatong Hu, Yiyuan Xu, Xiaoxiao Liu, Zhigang Li
OBJECTIVE: To investigate the effect of manual acupuncture (MA) on NLRP3 inflammasome-related proteins. METHODS: SAMP8 mice were randomly divided into Alzheimer's disease (AD) group, the MA group, and the medicine (M) group. Mice in the M group were treated with donepezil hydrochloride at 0.65 μg/g. In the MA group, MA was applied on Baihui (GV20) and Yintang (GV29) for 20 min and then pricked at Shuigou (GV26). The Morris water maze was applied to assess spatial learning and memory...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28904126/nlrp3-and-potassium-efflux-drive-rapid-il-1%C3%AE-release-from-primary-human-monocytes-during-toxoplasma-gondii-infection
#20
Lanny Gov, Christine A Schneider, Tatiane S Lima, William Pandori, Melissa B Lodoen
IL-1β is produced by myeloid cells and acts as a critical mediator of host defense during infection and injury. We found that the intracellular protozoan parasite Toxoplasma gondii induced an early IL-1β response (within 4 h) in primary human peripheral blood monocytes isolated from healthy donors. This process involved upregulation of IL-1β, IL-1RN (IL-1R antagonist), and NLRP3 transcripts, de novo protein synthesis, and the release of pro- and mature IL-1β from infected primary monocytes. The released pro-IL-1β was cleavable to mature bioactive IL-1β in the extracellular space by the protease caspase-1...
September 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
keyword
keyword
67907
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"