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https://www.readbyqxmd.com/read/28819951/metformin-a-new-old-drug
#1
Marta Patrycja Wróbel, Bogdan Marek, Dariusz Kajdaniuk, Dominika Rokicka, Aleksandra Szymborska-Kajanek, Krzysztof Strojek
For many years metformin has been the gold standard in the treatment of type 2 diabetes. According to recommendations of the most important diabetes associations, this is the first-choice drug for use as monotherapy in patients with newly diagnosed type 2 diabetes. Metformin is also recommended in combined treatment when monotherapy is no longer effective. It is then combined with a sulfony-lurea, an incretin, flozin, or insulin, irrespective of the number of insulin injections per day. Besides its properties used in the treatment of diabetes, metformin has been treated for some time as a drug of a so-called pleiotropic activity, as each year brings new reports about its favourable effect in different conditions...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28570736/preclinical-pet-study-of-intravitreal-injections
#2
Anxo Fernández-Ferreiro, Andrea Luaces-Rodríguez, Pablo Aguiar, Juan Pardo-Montero, Miguel González-Barcia, Lara García-Varela, Michel Herranz, Jesús Silva-Rodríguez, María Gil-Martínez, María A Bermúdez, Alba Vieites-Prado, José Blanco-Méndez, María Jesús Lamas, Francisco Gómez-Ulla, Álvaro Ruibal, Francisco Javier Otero-Espinar, Francisco González
Purpose: This work aimed at describing the time course of vitreous clearance through the use of positron emission tomography (PET) as a noninvasive tool for pharmacokinetic studies of intravitreal injection. Methods: The pharmacokinetic profile of intravitreal injections of molecules labeled with 18Fluorine (18F) was evaluated in adult Sprague Dawley rats by using a dedicated small-animal PET/computed tomography scanner. Different conditions were studied: three molecules radiolabeled with 18F (18F-FDG, 18F-NaF, and 18F-Choline), three volumes of intravitreal injections (7, 4, and 2 μL), and absence or presence of eye inflammation (uveitis)...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28186981/18f-fdg-18f-fes-standardized-uptake-value-ratio-determined-using-pet-predicts-prognosis-in-uterine-sarcoma
#3
Makoto Yamamoto, Tetsuya Tsujikawa, Shizuka Yamada, Tetsuji Kurokawa, Akiko Shinagawa, Yoko Chino, Tetsuya Mori, Yasushi Kiyono, Hidehiko Okazawa, Yoshio Yoshida
We investigated whether 16α-[18F]-fluoro-17β-estradiol (18F-FES) and 18F-fluoro-deoxyglucose (FDG) uptake measured using positron emission tomography (PET) predicted prognosis in 18 patients with different histological subtypes of uterine sarcoma. Standardized uptake values (SUVs) and 18F-FDG/18F-FES SUV ratios were determined, and their correlations with progression-free (PFS) and overall survival (OS) were examined. Ten patients died from local recurrence or metastasis, and one more experienced recurrence, during the at least 36-month follow-up period...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/27559736/kinetic-modeling-and-graphical-analysis-of-18f-fluoromethylcholine-fcho-18f-fluoroethyltyrosine-fet-and-18f-fluorodeoxyglucose-fdg-pet-for-the-fiscrimination-between-high-grade-glioma-and-radiation-necrosis-in-rats
#4
Julie Bolcaen, Kelly Lybaert, Lieselotte Moerman, Benedicte Descamps, Karel Deblaere, Tom Boterberg, Jean-Pierre Kalala, Caroline Van den Broecke, Filip De Vos, Christian Vanhove, Ingeborg Goethals
BACKGROUND: Discrimination between glioblastoma (GB) and radiation necrosis (RN) post-irradiation remains challenging but has a large impact on further treatment and prognosis. In this study, the uptake mechanisms of 18F-fluorodeoxyglucose (18F-FDG), 18F-fluoroethyltyrosine (18F-FET) and 18F-fluoromethylcholine (18F-FCho) positron emission tomography (PET) tracers were investigated in a F98 GB and RN rat model applying kinetic modeling (KM) and graphical analysis (GA) to clarify our previous results...
2016: PloS One
https://www.readbyqxmd.com/read/27313888/a-pilot-study-of-18f-flt-pet-ct-in-pediatric-lymphoma
#5
Danny L Costantini, Reza Vali, Susan McQuattie, Jeffrey Chan, Angela Punnett, Shiela Weitzman, Amer Shammas, Martin Charron
We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV 8.6 ± 0.6 and 5.0 ± 0.3, versus 18F-FDG SUV 1.9 ± 0.1 and 3.4 ± 0.7, resp., p < 0.05). In total, 15 lesions were evaluated with average 18F-FDG and 18F-FLT SUVs of 2.6 ± 0.1 and 2.0 ± 0...
2016: International Journal of Molecular Imaging
https://www.readbyqxmd.com/read/27271230/update-on-novel-imaging-techniques-for-the-detection-of-lymph-node-metastases-in-bladder-cancer
#6
Antti P Salminen, Ivan Jambor, Kari T Syvanen, Peter J Bostrom
Staging of muscle-invasive bladder cancer (MIBC) remains a challenge. It is generally acknowledged that the most commonly used imaging techniques have a trend to either upstage or downstage the disease. The aim of this review article is to evaluate the currently available scientific evidence for the use of imaging modalities in preoperative bladder cancer staging with special attention to the detection of lymph node metastasis (LNM). A non-systematic literature search utilizing PubMed database with terms MIBC and LN and MRI or PET or CT was performed with the search limited to articles published between 2010 and 2015...
April 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27167829/multiparametric-18f-fluorodeoxyglucose-18f-fluoromisonidazole-positron-emission-tomography-magnetic-resonance-imaging-of-locally-advanced-cervical-cancer-for-the-non-invasive-detection-of-tumor-heterogeneity-a-pilot-study
#7
Katja Pinker, Piotr Andrzejewski, Pascal Baltzer, Stephan H Polanec, Alina Sturdza, Dietmar Georg, Thomas H Helbich, Georgios Karanikas, Christoph Grimm, Stephan Polterauer, Richard Poetter, Wolfgang Wadsak, Markus Mitterhauser, Petra Georg
OBJECTIVES: To investigate fused multiparametric positron emission tomography/magnetic resonance imaging (MP PET/MRI) at 3T in patients with locally advanced cervical cancer, using high-resolution T2-weighted, contrast-enhanced MRI (CE-MRI), diffusion-weighted imaging (DWI), and the radiotracers [18F]fluorodeoxyglucose ([18F]FDG) and [18F]fluoromisonidazol ([18F]FMISO) for the non-invasive detection of tumor heterogeneity for an improved planning of chemo-radiation therapy (CRT). MATERIALS AND METHODS: Sixteen patients with locally advanced cervix were enrolled in this IRB approved and were examined with fused MP [18F]FDG/ [18F]FMISO PET/MRI and in eleven patients complete data sets were acquired...
2016: PloS One
https://www.readbyqxmd.com/read/27070087/preclinical-evaluation-of-the-anti-tumor-effects-of-the-natural-isoflavone-genistein-in-two-xenograft-mouse-models-monitored-by-18f-fdg-18f-flt-and-64cu-nodaga-cetuximab-small-animal-pet
#8
Valerie S Honndorf, Stefan Wiehr, Anna-Maria Rolle, Julia Schmitt, Luisa Kreft, Letitia Quintanilla-Martinez, Ursula Kohlhofer, Gerald Reischl, Andreas Maurer, Karsten Boldt, Michael Schwarz, Holger Schmidt, Bernd J Pichler
UNLABELLED: The natural phytoestrogen genistein is known as protein kinase inhibitor and tumor suppressor in various types of cancers. We studied its antitumor effect in two different xenograft models using positron emission tomography (PET) in vivo combined with ex vivo histology and nuclear magnetic resonance (NMR) metabolic fingerprinting. PROCEDURES: A431 and Colo205 tumor-bearing mice were treated with vehicle or genistein (500 mg/kg/d) over a period of 12 days...
May 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/26684180/lymph-node-imaging-in-bladder-cancer
#9
A P Salminen, I Jambor, K T Syvänen, P J Boström
Staging of muscle invasive bladder cancer (MIBC) remains a challenge. It is generally acknowledged that the most commonly used imaging techniques have a trend either to upstage or downstage the disease. The aim of this review article is to evaluate the currently available scientific evidence for the use of imaging modalities in preoperative bladder cancer staging with special attention to detection of lymph node metastasis (LNM). A non-systematic literature search utilizing PUBMED database with terms MIBC and LN and MRI or PET or CT was performed with the search limited to articles published between 2010-2015...
December 18, 2015: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/26388152/concordance-in-the-interpretation-of-pet-after-chemotherapy-in-advanced-stage-hodgkin-lymphoma
#10
MULTICENTER STUDY
C Kobe, G Kuhnert, H Haverkamp, M Fuchs, D Kahraman, H-T Eich, J Kriz, C Baues, B Nast-Kolb, P J Bröckelmann, P Borchmann, A Drzezga, A Engert, M Dietlein
UNLABELLED: The aim was to analyze the degree of agreement between the central review panel and the local PET interpretation within the HD15 trial and its impact on subsequent treatment and progression free survival. PATIENTS, METHODS: The analysis set consisted of 739 patients with residues ≥ 2.5 cm after 6 or 8 cycles of BEACOPPesc from the HD15 trial performed by the German Hodgkin Study Group. The recommendation for or against further radiotherapy was based on the central [(18)F]FDG-PET interpretation...
2015: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/26383153/multicenter-reproducibility-of-18f-fluciclatide-pet-imaging-in-subjects-with-solid-tumors
#11
MULTICENTER STUDY
Rohini Sharma, Kumar G Kallur, Jin S Ryu, Ramanathapuram V Parameswaran, Henrik Lindman, Norbert Avril, Fergus V Gleeson, Jong D Lee, Kyung-Han Lee, Michael J O'Doherty, Ashley M Groves, Matthew P Miller, Edward J Somer, Charles R Coombes, Eric O Aboagye
UNLABELLED: Integrins are upregulated on both tumor cells and associated vasculature, where they play an important role in angiogenesis and metastasis. Fluciclatide is an arginine-glycine-aspartic acid peptide with high affinity for αvβ3/αvβ5 integrin, which can be radiolabeled for PET imaging of angiogenesis. Thus, (18)F-fluciclatide is a potential biomarker of therapeutic response to antiangiogenic inhibitors. The aim of this study was to evaluate the reproducibility of (18)F-fluciclatide in multiple solid-tumor types...
December 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26382779/re-18f-fdg-pet-ct-impact-on-testicular-tumours-clinical-management
#12
COMMENT
Jerome P Richie
No abstract text is available yet for this article.
October 2015: Journal of Urology
https://www.readbyqxmd.com/read/26382774/re-potential-impact-of-18f-fdg-pet-ct-on-patients-selection-for-neoadjuvant-chemotherapy-before-radical-cystectomy
#13
COMMENT
Sam S Chang
No abstract text is available yet for this article.
October 2015: Journal of Urology
https://www.readbyqxmd.com/read/26379889/value-of-sequential-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-fdg-pet-ct-in-prediction-of-the-overall-survival-of-esophageal-cancer-patients-treated-with-chemoradiotherapy
#14
Yimin Li, Qin Lin, Zuoming Luo, Long Zhao, Luchao Zhu, Long Sun, Hua Wu
This study is to investigate the value of the metabolic parameters measured by sequential FDG PET/CT in predicting the overall survival of patients with esophageal squamous cell carcinoma (ESCC). A total of 160 patients who were newly diagnosed as ESCC patients and treated with chemoradiotherapy were included in this study. The FDG PET/CT was carried out prior to radiotherapy (PET1), when the cumulative dose of radiotherapy reached 50 Gy (PET2), at the end of radiotherapy (PET3) and 1 month after radiotherapy (PET4)...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26379847/clinical-significance-of-incidental-fdg-uptake-in-the-prostate-gland-detected-by-pet-ct
#15
Ertan Sahin, Umut Elboga, Ebuzer Kalender, Mustafa Basıbuyuk, Hasan Deniz Demir, Yusuf Zeki Celen
The value of FDG-positron emission tomography/computed tomography (PET/CT) for detecting prostate cancer is unknown. We aimed to investigate the clinical value of incidental prostate FDG uptake on PET/CT scans. We reviewed 6128 male patients who underwent FDG-PET/CT scans and selected cases that reported hypermetabolic lesion in the prostate. The patients who have prior history of prostate carcinoma or prostate surgery were excluded from the study. We have analyzed the correlation between PET/CT findings and serum prostate-specific antigen (PSA) levels, imaging (USG), urological examinations and biopsy...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26379620/fluid-biomarkers-in-clinical-trials-of-alzheimer-s-disease-therapeutics
#16
REVIEW
Aaron Ritter, Jeffrey Cummings
With the demographic shift of the global population toward longer life expectancy, the number of people living with Alzheimer's disease (AD) has rapidly expanded and is projected to triple by the year 2050. Current treatments provide symptomatic relief but do not affect the underlying pathology of the disease. Therapies that prevent or slow the progression of the disease are urgently needed to avoid this growing public health emergency. Insights gained from decades of research have begun to unlock the pathophysiology of this complex disease and have provided targets for disease-modifying therapies...
2015: Frontiers in Neurology
https://www.readbyqxmd.com/read/26378490/optimizing-an-18f-naf-and-18f-fdg-cocktail-for-pet-assessment-of-metastatic-castration-resistant-prostate-cancer
#17
Urban Simoncic, Scott Perlman, Glenn Liu, Robert Jeraj
BACKGROUND: PET/computed tomography (CT) imaging with the sodium-(F)-fluoride/2-(F)-fluoro-2-deoxy-D-glucose (F-NaF/F-FDG) cocktail has been proposed for patients with osseous metastases. This work aimed to optimize the cocktail composition for patients with metastatic castration-resistant prostate cancer (mCRPC). MATERIALS AND METHODS: The study was carried out on six patients with mCRPC, with a total of 26 analyzed lesions. The patients were injected with F-NaF and F-FDG at separate time points...
December 2015: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/26376736/visual-assessment-of-brain-perfusion-mri-scans-in-dementia-a-pilot-study
#18
David Fällmar, Johan Lilja, Vilma Velickaite, Torsten Danfors, Mark Lubberink, André Ahlgren, Matthias J P van Osch, Lena Kilander, Elna-Marie Larsson
PURPOSE: Functional imaging is becoming increasingly important for the detection of neurodegenerative disorders. Perfusion MRI with arterial spin labeling (ASL) has been reported to provide promising diagnostic possibilities but is not yet widely used in routine clinical work. The aim of this study was to compare, in a clinical setting, the visual assessment of subtracted ASL CBF maps with and without additional smoothing, to FDG-PET data. METHODS: Ten patients with a clinical diagnosis of dementia and 11 age-matched cognitively healthy controls were examined with pseudo-continuous ASL (pCASL) and 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET)...
May 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/26375670/double-autophagy-modulators-reduce-2-deoxyglucose-uptake-in-sarcoma-patients
#19
Mau-Shin Chi, Cheng-Yen Lee, Su-Chen Huang, Kai-Lin Yang, Hui-Ling Ko, Yen-Kung Chen, Chen-Han Chung, Kuang-Wen Liao, Kwan-Hwa Chi
RATIONALE: According to the metabolic symbiosis model, cancer stromal fibroblasts could be hijacked by surrounding cancer cells into a state of autophagy with aerobic glycolysis to help provide recycled nutrients. The purpose of this study was to investigate whether combined treatment with the autophagy inhibitor: hydroxychloroquine (HCQ) and the autophagy inducer: sirolimus (rapamycin, Rapa) would reduce glucose utilization in sarcoma patients. METHODS: Ten sarcoma patients who failed first-line treatment were enrolled in this study...
October 6, 2015: Oncotarget
https://www.readbyqxmd.com/read/26375438/prognostic-value-of-early-response-assessment-using-18f-fdg-pet-ct-in-chemotherapy-treated-patients-with-non-small-cell-lung-cancer
#20
Eun Ji Han, Young Jun Yang, Ji Chan Park, Suk Young Park, Woo Hee Choi, Sung Hoon Kim
OBJECTIVE: We aimed to evaluate the prognostic value of early response assessment using a volumetric fluorine-18-fluorodeoxyglucose (F-FDG) PET analysis in chemotherapy-treated patients with non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: We retrospectively reviewed 33 patients with NSCLC who received first-line chemotherapy and performed F-FDG PET/computed tomography before (baseline PET) and after two cycles of chemotherapy (interim PET). The maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) of the total malignant lesion were measured in baseline (SUV1 and MTV1) and interim (SUV2 and MTV2) PET images, and percentage changes in SUVmax (ΔSUV) and MTV (ΔMTV) were calculated between the two images...
December 2015: Nuclear Medicine Communications
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