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Ginette Y Azandémè Hounmalon, Nguya K Maniania, Saliou Niassy, Simon Fellous, Serge Kreiter, Emilie Delétré, Komi K Fiaboe, Thibaud Martin
BACKGROUND: Tetranychus evansi (Te) is an exotic pest of solanaceous crops in Africa. The predatory mite Phytoseiulus longipes (Pl) and the fungus Metarhizium anisopliae (Ma), are potential biocontrol agents of Te. The present study investigated efficacy of fungus-treated foam placed above or below the third Te-infested tomato leaf. The persistence of fungus-treated foam and the performance of Pl with or without fungus-treated foam were evaluated. RESULTS: The fungus-treated foam was effective when Te infestation was below the third tomato leaf as no damage was recorded on all upper tomato leaves up to 30 days post-treatment...
May 13, 2018: Pest Management Science
Ryo Endo, Noriko Takashima, Yoko Nekooki-Machida, Yusuke Komi, Kelvin Kai-Wan Hui, Masaki Takao, Hiroyasu Akatsu, Shigeo Murayama, Akira Sawa, Motomasa Tanaka
BACKGROUND: Neurodegenerative diseases involving protein aggregation often accompany psychiatric symptoms. Frontotemporal lobar degeneration (FTLD) associated with TAR DNA-binding protein 43 (TDP-43) aggregation is characterized by progressive neuronal atrophy in frontal and temporal lobes of cerebral cortex. Furthermore, patients with FTLD display mental dysfunction in multiple behavioral dimensions. Nevertheless, their molecular origin for psychiatric symptoms remains unclear. METHODS: In FTLD neurons and mouse models with TDP-43 aggregates, we examined coaggregation between TDP-43 and disrupted in schizophrenia 1 (DISC1), a key player in the pathology of mental conditions and its effects on local translation in dendrites and psychiatric behaviors...
March 29, 2018: Biological Psychiatry
Rie Imamaki, Kazuko Ogawa, Yasuhiko Kizuka, Yusuke Komi, Soichi Kojima, Norihiro Kotani, Koichi Honke, Takashi Honda, Naoyuki Taniguchi, Shinobu Kitazume
Most of the angiogenesis inhibitors clinically used in cancer treatment target the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) pathway. However, the current strategies for treating angiogenesis have limited efficacy. The issue of how to treat angiogenesis and endothelial dysfunction in cancer remains a matter of substantial debate. Here we demonstrate a glycosylation-dependent regulatory mechanism for tumor angiogenesis. St6gal1-/- mice, lacking the α2,6-sialylation enzyme, were shown to exhibit impaired tumor angiogenesis through enhanced endothelial apoptosis...
May 2, 2018: Oncogene
Samuel K Muchemi, Claus P W Zebitz, Christian Borgemeister, Komivi S Akutse, Caroline N Foba, Sunday Ekesi, Komi K M Fiaboe
In the scope of using Halticoptera arduine (Walker; Hymenoptera: Pteromalidae) in a classical biological control program in East Africa, laboratory bioassays were conducted to evaluate the acceptability and suitability of the three economically important Liriomyza leafminer species to the exotic parasitoid. Searching time, number of oviposition attempts, F1 parasitoid developmental period, parasitism rates, sex ratio, host mortality, and body size indices were assessed. H. arduine parasitized and developed successfully in the three Liriomyza species reported in East Africa...
April 13, 2018: Environmental Entomology
Vladimir Naumov, Michael Manton, Marine Elbakidze, Zigmars Rendenieks, Janis Priednieks, Siarhei Uhlianets, Taras Yamelynets, Anton Zhivotov, Per Angelstam
There are currently competing demands on Europe's forests and the finite resources and services that they can offer. Forestry intensification that aims at mitigating climate change and biodiversity conservation is one example. Whether or not these two objectives compete can be evaluated by comparative studies of forest landscapes with different histories. We test the hypothesis that indicators of wood production and biodiversity conservation are inversely related in a gradient of long to short forestry intensification histories...
April 13, 2018: Journal of Environmental Management
Samuel K Muchemi, Claus P W Zebitz, Christian Borgemeister, Komivi S Akutse, Caroline N Foba, Sunday Ekesi, Komi K M Fiaboe
Liriomyza spp., leafminer flies (Mik; Diptera: Agromyzidae), are economically important quarantine pests that puncture and mine leaves and fruits of various horticultural crops worldwide, affecting yield and trade. Halticoptera arduine (Walker; Hymenoptera: Pteromalidae), a key parasitoid from the pests' areas of origin in South America, was introduced as a potential alternative management strategy. Prior to H. arduine release, its potential interactions with the dominant local ectoparasitoid, Diglyphus isaea (Walker; Hymenoptera: Eulophidae), were assessed...
April 11, 2018: Environmental Entomology
Dominik Novák, Pavol Vadovič, Miroslav Ovečka, Olga Šamajová, George Komis, Jean Colcombet, Jozef Šamaj
Phospholipase D alpha 1 (PLDα1, At3g15730) and its product phosphatidic acid (PA) are involved in a variety of cellular and physiological processes, such as cytoskeletal remodeling, regulation of stomatal closure and opening, as well as biotic and abiotic stress signaling. Here we aimed to study developmental expression patterns and subcellular localization of PLDα1 in Arabidopsis using advanced microscopy methods such as light-sheet fluorescence microscopy (LSFM) and structured illumination microscopy (SIM)...
2018: Frontiers in Plant Science
Lilac Tene, Ilan Shelef, Dan Schwarzfuchs, Yftach Gepner, Anat Yaskolka Meir, Gal Tsaban, Hila Zelicha, Avital Bilitzky, Oded Komy, Noa Cohen, Nitzan Bril, Michal Rein, Dana Serfaty, Shira Kenigsbuch, Yoash Chassidim, Benjamin Sarusy, Uta Ceglarek, Michael Stumvoll, Matthias Blüher, Joachim Thiery, Meir J Stampfer, Assaf Rudich, Iris Shai
BACKGROUND & AIMS: The ability to mobilize pancreatic-fat and the meaning of decreased fat in the pancreas remain controversial. We followed the dynamics of pancreatic-fat and its morphology during various long weight-loss induced lifestyle-interventions. METHODS: In isolated workplace with monitored/provided lunch, we randomly assigned healthy persons with abdominal obesity or dyslipidemia for one of two 18-month equal-caloric diets: low-fat (LF) or Mediterranean/low-carbohydrate (Med/LC, with provided 1oz walnuts/day), with or without added moderate exercise (supervised gym membership)...
April 2018: Clinical Nutrition ESPEN
Mohamed Hussein Medhat El-Komy, Noha Adly Saleh, Marwah Adly Saleh
Oral erosions of pemphigus vulgaris (PV) represent a therapeutic challenge. In this work we compared intralesional injection of steroids (ILS) and autologous platelet-rich plasma (PRP) treatment of oral erosions of PV. In this split-mouth randomized double blind study, one side of the buccal mucosa of 11 PV patients was injected with 10 mg/ml triamcinolone and the opposite side was injected with 1 millilitre of autologous PRP every 14 days for 3 months. The percentage of clinical improvement, pemphigus disease area index and pain score were recorded before and after therapy...
May 2018: Archives of Dermatological Research
Samuel K Muchemi, Claus P W Zebitz, Christian Borgemeister, Komivi S Akutse, Caroline N Foba, Sunday Ekesi, Komi K M Fiaboe
Agromyzid Liriomyza leafminer flies are a major threat to horticultural production in East Africa with low natural control reported. The endoparasitoid Chrysocharis flacilla (Walker; Hymenoptera: Eulophidae) was introduced from Peru into quarantine facilities at ICIPE in Kenya for a leafminer classical biological control program. Interaction assays with one of the dominant local parasitoids, Diglyphus isaea (Walker; Hymenoptera: Eulophidae), using Liriomyza huidobrensis (Blanchard; Diptera: Agromyzidae) was assessed through sole, simultaneous and sequential releases...
April 2, 2018: Journal of Economic Entomology
George Komis, Olga Šamajová, Miroslav Ovečka, Jozef Šamaj
Plant mitogen-activated protein kinases (MAPKs) constitute a network of signaling cascades responsible for transducing extracellular stimuli and decoding them to dedicated cellular and developmental responses that shape the plant body. Over the last decade, we have accumulated information about how MAPK modules control the development of reproductive tissues and gametes and the embryogenic and postembryonic development of vegetative organs such as roots, root nodules, shoots, and leaves. Of key importance to understanding how MAPKs participate in developmental and environmental signaling is the characterization of their subcellular localization, their interactions with upstream signal perception mechanisms, and the means by which they target their substrates...
April 29, 2018: Annual Review of Plant Biology
Rodney N Nagoshi, Georg Goergen, Kodjo Agbeko Tounou, Komi Agboka, Djima Koffi, Robert L Meagher
Fall armyworm (Spodoptera frugiperda J.E. Smith) is a noctuid moth pest endemic throughout the Western Hemisphere that has recently become widespread in sub-Saharan Africa. There is a strong expectation of significant damage to African maize crop yield and a high likelihood of further dispersal, putting the rest of the Eastern Hemisphere at risk. Specimens from multiple locations in six countries spanning the northern portion of the infested region were analyzed for genetic markers. The similarity of haplotypes between the African collections was consistent with a common origin, but significant differences in the relative frequency of the haplotypes indicated limitations in migration...
February 27, 2018: Scientific Reports
Yumiko Ohhashi, Yoshiki Yamaguchi, Hiroshi Kurahashi, Yuji O Kamatari, Shinju Sugiyama, Boran Uluca, Timo Piechatzek, Yusuke Komi, Toshinobu Shida, Henrik Müller, Shinya Hanashima, Henrike Heise, Kazuo Kuwata, Motomasa Tanaka
Self-propagating β-sheet-rich fibrillar protein aggregates, amyloid fibers, are often associated with cellular dysfunction and disease. Distinct amyloid conformations dictate different physiological consequences, such as cellular toxicity. However, the origin of the diversity of amyloid conformation remains unknown. Here, we suggest that altered conformational equilibrium in natively disordered monomeric proteins leads to the adaptation of alternate amyloid conformations that have different phenotypic effects...
March 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
Eyram Fianyo, Owonayo Oniankitan, C Tagbor Komi, Kodjo Kakpovi, Prénam Houzou, E S Koffi-Tessio Viwalé, Moustafa Mijiyawa
BACKGROUND: The cost of low back pain was the subject of few studies in black Africa. AIM: To assess the cost of common low back pain and lumbar radiculopathy in Lomé. METHODS: A six months study was realised in the rheumatologic department of CHU Sylvanus Olympio. 103 consecutive patients suffering from a common low back pain or lumbar radiculopathy were included. To assess direct, indirect and non-financial costs they were questioned about their expense during the year...
March 2017: La Tunisie Médicale
Collins S K Ahorlu, Eric Koka, Susan Adu-Amankwah, Joseph Otchere, Dziedzom Komi de Souza
BACKGROUND: The Global Program for the Elimination of Lymphatic Filariasis (GPELF) started operation in 2000 and aimed at eliminating the disease by the year 2020, following 5-6 rounds of effective annual Mass Drug Administration (MDA). The MDA programme took off in Ghana in 2001 and has interrupted transmission in many areas while it has persisted in some areas after 10 or more rounds of MDA. This study was to appreciate community members' perspectives on MDA after over 15 years of implementation...
February 13, 2018: BMC Public Health
Yoshihiro Tokudome, Tatsuya Komi, Ami Omata, Marie Sekita
Restoring hyaluronic acid (HA) content is important for maintaining the function of photo-aged skin. This study aimed to evaluate the passive delivery into skin of HA nanoparticles formed by the polyion complex method. Nanoparticles were prepared by mixing and stirring anionic HA with a cationic polymer, protamine, at the charge ratio 55:45. The permeation of fluorescently-labelled HA nanoparticles (HANP) or free HA through hairless mouse skin was characterized in vitro. HANP or free HA was applied to ultraviolet (UV)-irradiated mice in vivo, and their transepidermal water loss (TEWL) was measured after 4 days...
February 5, 2018: Scientific Reports
Komi Mati, Korede K Adegoke, Abimbola Michael-Asalu, Hamisu M Salihu
OBJECTIVE: To examine the effect of the newly introduced national health insurance plan on access to skilled birth attendance (SBA). METHODS: The present secondary analysis used data from the 2014 Togo Demographic and Health Survey. The study sample comprised women aged 15-49 years who had at least one delivery in the 5 years preceding the survey. Multivariate logistic regression analyses were conducted. RESULTS: The adjusted sample included 4826 women...
January 25, 2018: International Journal of Gynaecology and Obstetrics
Issaka Maman, Tchadjobo Tchacondo, Abiba Banla Kere, Ebekalisai Piten, Marcus Beissner, Yiragnima Kobara, Komlan Kossi, Kossi Badziklou, Franz Xaver Wiedemann, Komi Amekuse, Gisela Bretzel, Damintoti Simplice Karou
BACKGROUND: Buruli ulcer (BU) is a neglected mycobacterial skin infection caused by Mycobacterium ulcerans. This disease mostly affects poor rural populations, especially in areas with low hygiene standards and sanitation coverage. The objective of this study was to identify these risk factors in the districts of Zio and Yoto of the Maritime Region in Togo. METHODS: We conducted a case-control study in Zio and Yoto, two districts proved BU endemic from November 2014 to May 2015...
January 19, 2018: BMC Infectious Diseases
Petr Triska, Nikolay Chekanov, Vadim Stepanov, Elza K Khusnutdinova, Ganesh Prasad Arun Kumar, Vita Akhmetova, Konstantin Babalyan, Eugenia Boulygina, Vladimir Kharkov, Marina Gubina, Irina Khidiyatova, Irina Khitrinskaya, Ekaterina E Khrameeva, Rita Khusainova, Natalia Konovalova, Sergey Litvinov, Andrey Marusin, Alexandr M Mazur, Valery Puzyrev, Dinara Ivanoshchuk, Maria Spiridonova, Anton Teslyuk, Svetlana Tsygankova, Martin Triska, Natalya Trofimova, Edward Vajda, Oleg Balanovsky, Ancha Baranova, Konstantin Skryabin, Tatiana V Tatarinova, Egor Prokhortchouk
BACKGROUND: The history of human populations occupying the plains and mountain ridges separating Europe from Asia has been eventful, as these natural obstacles were crossed westward by multiple waves of Turkic and Uralic-speaking migrants as well as eastward by Europeans. Unfortunately, the material records of history of this region are not dense enough to reconstruct details of population history. These considerations stimulate growing interest to obtain a genetic picture of the demographic history of migrations and admixture in Northern Eurasia...
December 28, 2017: BMC Genetics
Nidain Maneh, Kossivi Apetse, Bénédicte Marèbe Diatewa, Sidik Abou-Bakr Domingo, Aidé Isabelle Agba, Koffi Didier Ayena, Koffi Agnon Balogou, Komi Patrice Balo
Myasthenia gravis is a rare acquired autoimmune pathology causing neuromuscular transmission impairment. Juvenile onset of myasthenia gravis is often characterized by ocular involvement. We report two cases of ocular juvenile myasthenia gravis (JMG) in two siblings. They were two young girls, XA and XB, aged 11 and 9 years, of Malian origin, residing in Togo, born from first-degree of consanguinity presenting to Ophthalmology due to progressive decrease in visual acuity. XA showed visual acuity 8/10 on both eyes while XB showed improvement in visual acuity from 3/10 to 7/10 using a pinhole occluder, suggesting ametropia...
2017: Pan African Medical Journal
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