Komi

Mathematical models of epidermal and dermal transport are essential for optimization and development of products for percutaneous delivery both for local and systemic indication and for evaluation of dermal exposure to chemicals for assessing their toxicity. These models often help directly by providing information on the rate of drug penetration through the skin and thus on the dermal or systemic concentration of drugs which is the base of their pharmacological effect. The simulations are also helpful in analyzing experimental data, reducing the number of experiments and translating the in vitro investigations to an in-vivo setting...

This study documents the socio-economic baselines in selected oil-impacted communities prior to the commencement of the Ogoni clean-up and restoration project. Adopting mixed approach consisting of semi-structured interviews, focus group discussions (FGDs), key informant interviews (KIIs), and household surveys, we surveyed the pre-remediation socio-economic conditions in the Ogoniland communities between July 2018 and March 2019. Results indicated that almost all respondents (99.6%) agreed that the smell of petroleum products or crude oil was evident in the air they breathed even as there were visible black particles (soot) in the respondents' nostrils, on their clothes, and in water...

BACKGROUND: Psoriasis is a common chronic, immune-mediated inflammatory skin disease. Despite the availability of several systemic therapeutic agents, treatment of psoriasis remains a challenge because of the associated adverse effects and/or the financial burden of these medications, given the chronicity of the disease. AIM: We aimed to compare the efficacy and safety of combined pulse azathioprine (AZA) and low dose methotrexate versus conventional dose of methotrexate (MTX) in patients with chronic plaque psoriasis...

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The mechanisms of the pathogenesis of neck paraganglioma (PGL) and the possible role of mast cells (MCs) in its development and metastasis are still poorly understood. We analyzed MCs' morphologic characterization, activation, and the properties of their cytoplasmic/released granules in PGLs, using light and transmission electron microscopy. Paragangliomas showed a large tumor-associated MC population both in the connective tissue layers of the tumor and between the tumor cells. Notably, MCs were presented by a high expression of specific proteases, size variation, polymorphism, and variable ultrastructural phenotype of granules...

BACKGROUND: Brain tissue in Alzheimer's patients is exposed to oxidative stress. Silymarin is an adjunct drug that has anti-inflammatory and antioxidant properties. OBJECTIVE: This study aimed to evaluate the effect of silymarin on biomarkers of oxidative stress, inflammation, and disease severity in Alzheimer's patients. METHODS: This randomized, single-blind clinical trial study was performed on 33 patients with Alzheimer's disease (AD) whose disease was confirmed by DSM-5 criteria and by brain imaging...

Knowledge of insect pest ecology and biology is important for maximizing crop protection and reducing crop losses. Currently, we lack an efficient control program for the cocoa mirid Sahlbergella singularis Haglund (Hemiptera: Miridae), the principal insect pest of cocoa in West and Central Africa. A 2-yr study was conducted in 11 plantations across Ayos and Konye, two of the largest cocoa growing areas of Cameroon. We evaluated the effects of mirid sex pheromone and climatic variations on mirid population dynamics and their associated cocoa damage...

Mast cells (MCs) are commonly recognized for their crucial involvement in the pathogenesis of allergic diseases, but over time, it has come to light that they also play a role in the pathophysiology of non-allergic disorders including atherosclerosis. The involvement of MCs in the pathology of atherosclerosis is supported by their accumulation in atherosclerotic plaques upon their progression and the association of intraplaque MC numbers with acute cardiovascular events. MCs that accumulate within the atherosclerotic plaque release a cocktail of mediators through which they contribute to neovascularization, plaque progression, instability, erosion, rupture, and thrombosis...

No abstract text is available yet for this article.

For the first time, we investigated species composition, phytoplankton community structure, and hydrochemical parameters in the artificial cooling reservoir of a major thermal power plant (TPP) in northeastern Europe located in the Pechora River basin (Komi Republic). Our research, conducted during June and August, revealed a total of 81 species of algae and cyanobacteria, with cyanobacteria predominating. Among these cyanobacteria and microalgae (Bacillariophyta and Chlorophyta), algae that serve as reliable indicators of water quality were identified...

BACKGROUND AND AIMS: Systemic sclerosis (SSc) is a common autoimmune disorder involving the skin, blood vessels, and internal organs with an elusive pathophysiology. SSc is believed to be a genetically prone T-cell-mediated autoimmune disease. miRNAs and lncRNAs were thought to be involved in the etiology of several immunological diseases including SSc. This work aimed to assess the expression of miRNA-133, lncRNA-H19, PKM2, and TGF-β levels in SSc in comparison to controls and their relationship to the clinical course and severity of disease...

The present study investigated the influence of exposing quail eggs to low-dose gamma radiation (GR) and in ovo feeding with 2 sources of a mixture of trace elements (Zn, Fe, and Cu), including sulfate (TES) and loaded with montmorillonite (TEM), on embryonic development activities and prehatch quality. A total of 960 eggs on the seventh day of incubation were randomly divided into 6 groups (160 eggs/group) with 4 replicate of 40 eggs in each. A 3 × 2 factorial arrangement experiment was performed and included 3 sources in ovo feeding with a mixture of trace elements (Zn, Fe, and Cu), including 0 mg/egg, 50 mg TES/egg, and 50 mg TEM/egg with egg irradiation using 0 and 0...

BACKGROUND: The food manufacturing industry is a critical economic sector and has been a high-risk industry for COVID-19. This analysis aimed to describe COVID-19 cumulative case incidence rates among Wisconsin food manufacturing workers and their worker's compensation utilization. METHODS: This was a descriptive analysis of COVID-19 cases among food manufacturing industry workers in Wisconsin from October 1, 2020, through December 31, 2021. RESULTS: Occupations with the highest cumulative case incidence rate (per 1000 workers) were Packers and Packagers, Hand (275; 95% CI, 252-300), Packaging and Filling Machine Operators and Tenders (266; 95% CI, 254-277), and Laborers and Freight, Stock and Material Movers, Hand (261; 95% CI, 247-276)...

INTRODUCTION: Work is central to the discourse surrounding the pandemic. Going to work during the COVID-19 pandemic put individuals at risk for both disease and death. This study assesses COVID-19 mortality by industry and occupation for working-age adults in Wisconsin and applies a health equity lens to understand COVID-19, demographics, work, and mortality in the state. METHODS: We used vital records data to evaluate COVID-19 mortality in Wisconsin. We assessed the demographics of working-age decedents using chi-square tests and logistic regression...

BACKGROUND: Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels of fibrin(ogen) in the brain, behavioral changes, and mortality. However, the role of TNF in eCM within the brain parenchyma, particularly directly on neurons, remains underdefined. Here, we investigate electrophysiological consequences of eCM on neuronal excitability and cell signaling mechanisms that contribute to observed phenotypes...

Recently, the concept of skin effect has gained considerable attention in the context of non-Hermitian photonics. The experimental realization of Hatano-Nelson systems in optical coupled cavities has provided the opportunity to consider the effect of optical nonlinearity. In this work, we probe the interplay between Kerr nonlinearity and non-Hermiticity in a Hatano-Nelson lattice. In particular, we examine the relation between self-focusing and the skin effect under single-channel excitation. Moreover, we numerically identify skin soliton solutions, which exhibit power threshold and spatial asymmetry...

BACKGROUND: Monkeypox is a zoonotic disease caused by the monkeypox virus, an Orthopox virus. The 2022 monkeypox outbreak provoked fear among the public. Public awareness about the disease could be an important factor in its control. The authors conducted this study to assess the perception and prediction of monkeypox among the Middle East public. METHODS: This cross-sectional study was conducted in August 2022. Data were conveniently collected from eight Middle Eastern countries using an online self-administered questionnaire distributed through educational and social media platforms...

BACKGROUND: Adult female acne is characterized by a relapsing eruption of acne in individuals who are 25 years or older. It usually shows slower response to the traditional adolescent acne treatments. Usually, androgens promote acne by stimulating sebum production, while estrogens have the opposite effect by reducing sebum output when present in adequate quantities. Estradiol is the female sex hormone with the highest absolute serum levels and the highest estrogenic activity during a woman's reproductive years...

No abstract text is available yet for this article.

No abstract text is available yet for this article.