keyword
MENU ▼
Read by QxMD icon Read
search

Nociception monitoring

keyword
https://www.readbyqxmd.com/read/27875927/what-is-being-trained-how-divergent-forms-of-plasticity-compete-to-shape-locomotor-recovery-after-spinal-cord-injury
#1
J Russell Huie, Kazuhito Morioka, Jenny Haefeli, Adam R Ferguson
Spinal cord injury (SCI) is a devastating syndrome that produces dysfunction in motor and sensory systems, manifesting as chronic paralysis, sensory changes, and pain disorders. The multifaceted and heterogeneous nature of SCI has made effective rehabilitative strategies challenging. Work over the last 40 years has aimed to overcome these obstacles by harnessing the intrinsic plasticity of the spinal cord to improve functional locomotor recovery. Intensive training after SCI facilitates lower extremity function and has shown promise as a tool for retraining the spinal cord by engaging innate locomotor circuitry in the lumbar cord...
November 22, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27807964/analgesia-nociception-monitoring-for-opioid-guidance-meta-analysis-of-randomized-clinical-trials
#2
Matthias Gruenewald, Astrid Dempfle
BACKGROUND: The adequate suppression of nociception is, besides induction of unconsciousness and immobility, the main objective during anaesthesia. Analgesics, most commonly opioids, are usually titrated by established clinical surrogates of nociception. Recently, monitoring techniques became available to evaluate analgesia/nociception during anaesthesia and provide better measures then clinical evaluation alone. They are primarily derived from autonomic response on physiologic standard measures...
November 3, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27766525/comparison-of-the-qcon-and-qnox-indices-for-the-assessment-of-unconsciousness-level-and-noxious-stimulation-response-during-surgery
#3
Umberto Melia, Eva Gabarron, Mercé Agustí, Nuria Souto, Patricia Pineda, Joan Fontanet, Montserrat Vallverdu, Erik Weber Jensen, Pedro Gambus
The objective of this work is to compare the performances of two electroencephalogram based indices for detecting loss of consciousness and loss of response to nociceptive stimulation. Specifically, their behaviour after drug induction and during recovery of consciousness was pointed out. Data was recorded from 140 patients scheduled for general anaesthesia with a combination of propofol and remifentanil. The qCON 2000 monitor (Quantium Medical, Barcelona, Spain) was used to calculate the qCON and qNOX. Loss of response to verbal command and loss of eye-lash reflex were assessed during the transition from awake to anesthetized, defining the state of loss of consciousness...
October 20, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27749829/trpa1-mediates-sensation-of-the-rate-of-temperature-change-in-drosophila-larvae
#4
Junjie Luo, Wei L Shen, Craig Montell
Avoidance of noxious ambient heat is crucial for survival. A well-known phenomenon is that animals are sensitive to the rate of temperature change. However, the cellular and molecular underpinnings through which animals sense and respond much more vigorously to fast temperature changes are unknown. Using Drosophila larvae, we found that nociceptive rolling behavior was triggered at lower temperatures and at higher frequencies when the temperature increased rapidly. We identified neurons in the brain that were sensitive to the speed of the temperature increase rather than just to the absolute temperature...
October 17, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27742411/inhibition-of-reinforcing-hyperalgesic-and-motor-effects-of-morphine-by-buspirone-in-rats
#5
Darakhshan Jabeen Haleem, Shazia Nawaz
: Morphine and other opioids are among the most effective prescription medications for the treatment of pain. Addiction and hyperalgesia associated with their long-term use limits the clinical utility of these drugs. In view of a role of somatodendritic serotonin-1A receptors in addiction and analgesic effects of morphine, the present study concerns effects of co-use of buspirone, a partial agonist at the serotonin-1A receptor, on reinforcing, hyperalgesic, and motor effects of morphine in rats...
October 11, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27703336/profile-of-the-capsaicin-8-patch-for-the-management-of-neuropathic-pain-associated-with-postherpetic-neuralgia-safety-efficacy-and-patient-acceptability
#6
Muhammad Laklouk, Ganesan Baranidharan
Capsaicin is a naturally occurring irritant active ingredient found in hot peppers. It is a ligand for transient receptor potential channel vanilloid receptors, which are found in nociceptive nerve terminals in the skin. Initial exposure to topical capsaicin leads to excitation of these receptors, release of vasoactive mediators, erythema, intense burning, pain, and thereafter desensitization of sensory neurons resulting in inhibition of pain transmission. Capsaicin 8% has been licensed for the treatment of postherpetic neuralgia pain in recent years...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27702648/probing-pain-pathways-with-light
#7
Feng Wang, Erik Bélanger, Marie-Eve Paquet, Daniel Côté, Yves De Koninck
We have witnessed an accelerated growth of photonics technologies in recent years to enable not only monitoring the activity of specific neurons, while animals are performing certain types of behavior, but also testing whether specific cells, circuits, and regions are sufficient or necessary for initiating, maintaining, or altering this or that behavior. Compared to other sensory systems, however, such as the visual or olfactory system, photonics applications in pain research are only beginning to emerge. One reason pain studies have lagged behind is that many of the techniques originally developed cannot be directly implemented to study key relay sites within pain pathways, such as the skin, dorsal root ganglia, spinal cord, and brainstem...
October 1, 2016: Neuroscience
https://www.readbyqxmd.com/read/27693901/efficacy-and-safety-of-two-methadone-titration-methods-for-the-treatment-of-cancer-related-pain-the-equimeth2-trial-methadone-for-cancer-related-pain
#8
Philippe Poulain, Marie-Pierre Berleur, Shimsi Lefki, Danièle Lefebvre, Gisèle Chvetzoff, Eric Serra, Fibra Tremellat, Alain Derniaux, Marilène Filbet
CONTEXT: In the European Association for Palliative Care recommendations for cancer pain management, there was no consensus regarding the indications, titration or monitoring of methadone. OBJECTIVES: This national, randomized, multicentre trial aimed to compare two methadone titration methods (stop-and-go vs progressive) in patients with cancer-related pain who were inadequately relieved by or intolerant to level 3 opioids. METHODS: The primary endpoint was the rate of success/failure at Day 4, defined as pain relief (reduction of at least two points on the visual scale and a pain score <5 for 2 consecutive days) and no overdose (Rudkin scale ≥3 and respiratory rate <8/min)...
September 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27686494/chronic-administration-of-pyr-1-apelin-13-attenuates-neuropathic-pain-after-compression-spinal-cord-injury-in-rats
#9
Zahra Hajimashhadi, Nahid Aboutaleb, Farinaz Nasirinezhad
Apelin is an endogenous ligand for apelin receptor (APJ) with analgesic effect on visceral, analgesic and proanalgesic influences on acute pains in animal models. The purpose of this study was to determine the possible analgesic effects of [Pyr(1)] apelin-13 on chronic pain after spinal cord injury (SCI) in rats. Animals were randomly divided into three major groups as intact, sham and SCI. The SCI group randomly allocated to four subgroups as no treatment, vehicle-treatment (normal saline: 10μl, intrathecally) and two subgroups with intrathecal injection (i...
September 2, 2016: Neuropeptides
https://www.readbyqxmd.com/read/27622550/the-antinociceptive-properties-of-the-corydalis-yanhusuo-extract
#10
Lien Wang, Yan Zhang, Zhiwei Wang, Nian Gong, Tae Dong Kweon, Benjamin Vo, Chaoran Wang, Xiuli Zhang, Jae Yoon Chung, Amal Alachkar, Xinmiao Liang, David Z Luo, Olivier Civelli
Corydalis yanhusuo. W.T. extracts (YHS) are widely used for the treatment of pain and inflammation. There are a few studies that assessed the effects of YHS in pain assays; however, none of these studies has systematically compared its activities in the different pain animal modes namely: acute, inflammatory and chronic pain. Furthermore, little is known about the mechanism of YHS activity in these assays. The aim of this study was to systematically evaluate the antinociceptive properties of YHS by testing it in four standardized pain assays and to investigate its mechanism...
2016: PloS One
https://www.readbyqxmd.com/read/27538603/electrophysiological-assessment-of-nociception-in-patients-with-parkinson-s-disease-a-multi-methods-approach
#11
Janosch A Priebe, Miriam Kunz, Christian Morcinek, Peter Rieckmann, Stefan Lautenbacher
OBJECTIVE: Nociceptive abnormalities indicating increased pain sensitivity have been reported in patients with Parkinson's disease (PD). The disturbances are mostly responsive to dopaminergic (DA) treatment; yet, there are conflicting results. The objective of the present study was to investigate pain processing and nociception in PD patients in a more comprehensive manner than previous studies. For this purpose, a multi-methods approach was used in order to monitor different levels of the central nervous system (spinal, subcortical-vegetative, cortical)...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27421789/effect-of-subacute-agomelatine-treatment-on-painful-diabetic-neuropathy-involvement-of-catecholaminergic-mechanisms
#12
Taliha H Aydın, Özgür D Can, Ümide Demir Özkay, Nazlı Turan
In this study, we investigated the effects of subacute agomelatine (40 and 80 mg/kg) administration on chronic hyperglycemia, metabolic parameters, and pain perception in streptozotocin-induced diabetic rats. Fasting blood glucose measurements and oral glucose tolerance tests were performed to evaluate the effect of agomelatine on glycemia, while metabolic parameters were monitored using metabolic cages. Potential effect of agomelatine on diabetes-induced mechanical and thermal allodynia was evaluated using dynamic plantar aesthesiometer and warm plate (38 °C) tests, respectively...
December 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27418174/antinociceptive-effects-of-botulinum-toxin-type-a-on-trigeminal-neuropathic-pain
#13
K Y Yang, M J Kim, J S Ju, S K Park, C G Lee, S T Kim, Y C Bae, D K Ahn
Previous studies have demonstrated that botulinum toxin type A (BoNT-A) attenuates orofacial nociception. However, there has been no evidence of the participation of the voltage-gated sodium channels (Navs) in the antinociceptive mechanisms of BoNT-A. This study investigated the cellular mechanisms underlying the antinociceptive effects of BoNT-A in a male Sprague-Dawley rat model of trigeminal neuropathic pain produced by malpositioned dental implants. The left mandibular second molar was extracted under anesthesia, followed by a miniature dental implant placement to induce injury to the inferior alveolar nerve...
September 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27411333/a-novel-multivariate-steady-state-index-during-general-anesthesia-stan
#14
Ana Castro, Fernando Gomes de Almeida, Pedro Amorim, Catarina S Nunes
The assessment of the adequacy of general anesthesia for surgery, namely the nociception/anti-nociception balance, has received wide attention from the scientific community. Monitoring systems based on the frontal EEG/EMG, or autonomic state reactions (e.g. heart rate and blood pressure) have been developed aiming to objectively assess this balance. In this study a new multivariate indicator of patients' steady-state during anesthesia (STAN) is proposed, based on wavelet analysis of signals linked to noxious activation...
July 13, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27403261/administration-of-orexin-receptor-1-antagonist-into-the-rostral-ventromedial-medulla-increased-swim-stress-induced-antinociception-in-rat
#15
Neda Soliemani, Alireza Moslem, Ali Shamsizadeh, Hassan Azhdari-Zarmehri
OBJECTIVES: Intracerebroventricular injection of orexin-A (hypocretin-1) antagonist has been shown to inhibit stress-induced analgesia. However the locations of central sites that may mediate these effects have not been totally demonstrated. This study was performed to investigate the role of rostral ventromedial medulla (RVM) orexin receptor 1 in stress-induced analgesia (SIA). MATERIALS AND METHODS: Forced swim stress in water was employed to adult male rats (200-250 g)...
May 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27383702/selective-5-ht7-receptor-agonists-lp-44-and-lp-211-elicit-an-analgesic-effect-on-formalin-induced-orofacial-pain-in-mice
#16
Kadriye Demirkaya, Özlem Martı Akgün, Buğra Şenel, Zeynep Öncel Torun, Melik Seyrek, Enza Lacivita, Marcello Leopoldo, Ahmet Doğrul
OBJECTIVE: To investigate the antinociceptive effects of pharmacological activation of 5-HT7 receptors on orofacial pain in mice. MATERIAL AND METHODS: Nociception was evaluated by using an orofacial formalin test in male Balb-C mice. Selective 5-HT7 receptor agonists, LP 44 and LP 211 (1, 5, and 10 mg/kg), were given intraperitoneally 30 min prior to a formalin injection. A bolus of 10 µl of 4% subcutaneous formalin was injected into the upper lip of mice and facial grooming behaviors were monitored...
May 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/27342418/multiple-impairments-of-cutaneous-nociceptor-function-induced-by-cardiotoxic-doses-of-adriamycin-in-the-rat
#17
Krisztina Boros, Gábor Jancsó, Mária Dux, Zoltán Fekécs, Péter Bencsik, Orsolya Oszlács, Márta Katona, Péter Ferdinandy, Antal Nógrádi, Péter Sántha
Besides their deleterious action on cardiac muscle, anthracycline-type cytostatic agents exert significant neurotoxic effects on primary sensory neurons. Since cardiac sensory nerves confer protective effects on heart muscle and share common traits with cutaneous chemosensitive nerves, this study examined the effects of cardiotoxic doses of adriamycin on the function and morphology of epidermal nerves. Sensory neurogenic vasodilatation, plasma extravasation, and the neural CGRP release evoked by TRPV1 and TRPA1 agonists in vitro were examined by using laser Doppler flowmetry, the Evans blue technique, and ELISA, respectively...
September 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27302030/propofol-medetomidine-ketamine-total-intravenous-anaesthesia-in-thiafentanil-medetomidine-immobilized-impala-aepyceros-melampus
#18
Roxanne K Buck, Leith Rc Meyer, George F Stegmann, Sabine Br Kästner, Maya Kummrow, Christina Gerlach, Geoffrey T Fosgate, Gareth E Zeiler
OBJECTIVE: To characterize a propofol-medetomidine-ketamine total intravenous anaesthetic in impala (Aepyceros melampus). STUDY DESIGN: Prospective clinical study. ANIMALS: Ten adult female impala. MATERIALS AND METHODS: Impala were immobilized at 1253 m above sea level with 2.0 mg thiafentanil and 2.2 mg medetomidine via projectile darts. Propofol was given to effect (0.5 mg kg(-1) boluses) to allow endotracheal intubation, following which oxygen was supplemented at 2 L minute(-1) ...
June 15, 2016: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/27297686/pain-in-fabry-disease-practical-recommendations-for-diagnosis-and-treatment
#19
Juan M Politei, Didier Bouhassira, Dominique P Germain, Cyril Goizet, Antonio Guerrero-Sola, Max J Hilz, Elspeth J Hutton, Amel Karaa, Rocco Liguori, Nurcan Üçeyler, Lonnie K Zeltzer, Alessandro Burlina
AIMS: Patients with Fabry disease (FD) characteristically develop peripheral neuropathy at an early age, with pain being a crucial symptom of underlying pathology. However, the diagnosis of pain is challenging due to the heterogeneous and nonspecific symptoms. Practical guidance on the diagnosis and management of pain in FD is needed. METHODS: In 2014, experts met to discuss recent advances on this topic and update clinical guidance. RESULTS: Emerging disease-specific tools, including FabryScan, Fabry-specific Pediatric Health and Pain Questionnaire, and Würzburg Fabry Pain Questionnaire, and more general tools like the Total Symptom Score can aid diagnosis, characterization, and monitoring of pain in patients with FD...
July 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27231046/cav1-2-and-cav1-3-l-type-calcium-channels-independently-control-short-and-long-term-sensitization-to-pain
#20
Houda Radwani, Maria José Lopez-Gonzalez, Daniel Cattaert, Olivier Roca-Lapirot, Eric Dobremez, Rabia Bouali-Benazzouz, Emelía Eiríksdóttir, Ülo Langel, Alexandre Favereaux, Mohammed Errami, Marc Landry, Pascal Fossat
KEY POINTS: L-type calcium channels in the CNS exist as two subunit forming channels, Cav1.2 and Cav1.3, which are involved in short- and long-term plasticity. We demonstrate that Cav1.3 but not Cav1.2 is essential for wind-up. These results identify Cav1.3 as a key conductance responsible for short-term sensitization in physiological pain transmission. We confirm the role of Cav1.2 in a model of long-term plasticity associated with neuropathic pain. Up-regulation of Cav1.2 and down-regultation of Cav1...
November 15, 2016: Journal of Physiology
keyword
keyword
67897
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"