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Nociception monitoring

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https://www.readbyqxmd.com/read/29916863/parasympathetic-tone-activity-evaluation-to-discriminate-ketorolac-and-ketorolac-tramadol-analgesia-level-in-swine
#1
Carlos J Leitão, Juan Rafael Lima-Rodríguez, Fatima Ferreira, Catarina Avelino, Francisco M Sánchez-Margallo, Luís Antunes
BACKGROUND: Evaluation of nociceptive-antinociceptive balance during general anesthesia is still challenging and routinely based on clinical criteria. Analgesic drug delivered may be optimized with parasympathetic tone activity (PTA) monitor. This study compares ketorolac and ketorolac/tramadol balance analgesia using a PTA monitor. METHODS: Pain intensity response was assessed using a 0-100 numerical state scale (PTA) after nociceptive stimuli in pigs under stable sevoflurane anesthesia...
June 14, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29913971/brain-activation-due-to-postoperative-pain-from-the-right-hand-measured-with-regional-cerebral-blood-flow-using-positron-emission-tomography
#2
Torsten Gordh, Bertil Vinnars, Håkan Fischer, Hans Blomberg, Jan Modig, Mats Fredrikson, Per Hartvig
Background Brain activation resulting from acute postoperative pain has to our knowledge not previously been studied using positron emission tomography, except from one case study. The aim of this study was to monitor activation in brain sensory pathways during acute pain after surgery of the hand. A secondary aim was to compare brain activation in clinical postoperative pain to that previously reported, by the same research group, for a model of experimental pain from the same body area. Increase in regional cerebral blood flow (rCBF) is presumed to indicate neuronal activation and decrease in blood flow decreased neuronal firing...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913949/long-term-pain-neuroinflammation-and-glial-activation
#3
Elisabeth Hansson
Nociceptive and neuropathic pain signals are known to result from noxious stimuli, which are converted into electrical impulses within tissue nociceptors. There is a complex equilibrium of pain-signalling and pain-relieving pathways connecting PNS and CNS. Drugs against long-term pain are today directed against increased neuronal excitability, mostly with less success. An injury often starts with acute physiological pain, which becomes inflammatory, nociceptive, or neuropathic, and may be transferred into long-term pain...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29779036/development-of-a-hemodynamic-model-using-routine-monitoring-parameters-for-nociceptive-responses-evaluation-during-surgery-under-general-anesthesia
#4
Munetaka Hirose, Yoshiko Kobayashi, Shiro Nakamoto, Ryusuke Ueki, Nobutaka Kariya, Tsuneo Tatara
BACKGROUND Routine hemodynamic monitoring parameters under general anesthesia, such as heart rate (HR), systolic blood pressure (SBP), and perfusion index (PI), do not solely reflect intraoperative nociceptive levels. We developed a hemodynamic model combining these 3 parameters for nociceptive responses during general anesthesia, and evaluated nociceptive responses to surgical skin incision. MATERIAL AND METHODS We first retrospectively performed discriminant analysis using 3 values - HR, SBP, and PI - to assess response to skin incision during tympanoplasty, laparoscopic cholecystectomy, and open gastrectomy to determine if combined use of these parameters differentiates nociceptive levels among these 3 surgeries...
May 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29756750/validation-of-the-pmd100tm-and-its-noltm-index-to-detect-nociception-at-different-infusion-regimen-of-remifentanil-in-patients-under-general-anaesthesia
#5
Pierre-André Stöckle, Marco Julien, Rami Issa, Elizabeth Décary, Véronique Brulotte, Pierre Drolet, Margaret Henri, Madeleine Poirier, Jean-François Latulippe, Marc Dorais, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé
BACKGROUND: The NOL index is based on multiparametric analysis of heart rate (HR), skin conductance, wave plethysmography, and their time derivative. Our objective was to evaluate the NOL to detect standardized nociceptive stimuli with various remifentanil dosages under general anaesthesia. METHODS: A prospective, observational study at a single center (NCT02602379) included 40 ASA I to III patients undergoing laparotomy under remifentanil-desflurane anaesthesia with epidural analgesia...
May 14, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29739535/do-we-feel-pain-during-anesthesia-a-critical-review-on-surgery-evoked-circulatory-changes-and-pain-perception
#6
REVIEW
A Cividjian, F Petitjeans, N Liu, M Ghignone, M de Kock, L Quintin
The difficulty of defining the three so-called components of « an-esthesia » is emphasized: hypnosis, absence of movement, and adequacy of anti-nociception (intraoperative « analgesia »). Data obtained from anesthetized animals or humans delineate the activation of cardiac and vasomotor sympathetic reflex (somato-sympathetic reflex) and the cardiac parasympathetic deactivation observed following somatic stimuli. Sympathetic activation and parasympathetic deactivation are used as monitors to address the adequacy of intraoperative anti-nociception...
December 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/29707744/trpv4-mediated-anti-nociceptive-effect-of-suberanilohydroxamic-acid-on-mechanical-pain
#7
Geunyeol Choi, Tae-Jin Yang, Sungjae Yoo, Seung-In Choi, Ji Yeon Lim, Pyung Sun Cho, Sun Wook Hwang
Biological effects of suberanilohydroxamic acid (SAHA) have mainly been observed in the context of tumor suppression via epigenetic mechanisms, but other potential outcomes from its use have also been proposed in different fields such as pain modulation. Here, we tried to understand whether SAHA modulates specific pain modalities by a non-epigenetic unknown mechanism. From 24 h Complete Freund's Adjuvant (CFA)-inflamed hind paws of mice, mechanical and thermal inflammatory pain indices were collected with or without immediate intraplantar injection of SAHA...
April 29, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29703787/dissociation-between-csd-evoked-metabolic-perturbations-and-meningeal-afferent-activation-and-sensitization-implications-for-mechanisms-of-migraine-headache-onset
#8
Jun Zhao, Dan Levy
The onset of the headache phase during attacks of migraine with aura, which occur in ∼30% of migraineurs, is believed to involve cortical spreading depression (CSD) and the ensuing activation and sensitization of primary afferent neurons that innervate the intracranial meninges, and their related large vessels. The mechanism by which CSD enhances the activity and mechanosensitivity of meningeal afferents remains poorly understood, but may involve cortical metabolic perturbations. We used extracellular single-unit recording of meningeal afferent activity and monitored changes in cortical blood flow and tissue partial pressure of oxygen (tpO2 ) in anesthetized male rats to test whether the prolonged cortical hypoperfusion and reduction in tissue oxygenation that occur in the wake of CSD contribute to meningeal nociception...
May 30, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29694394/differential-processing-of-nociceptive-input-within-upper-limb-muscles
#9
Nathanial R Eckert, Brach Poston, Zachary A Riley
The cutaneous silent period is an inhibitory evoked response that demonstrates a wide variety of responses in muscles of the human upper limb. Classically, the cutaneous silent period results in a characteristic muscle pattern of extensor inhibition and flexor facilitation within the upper limb, in the presence of nociceptive input. The aims of the current study were: 1) to primarily investigate the presence and characteristics of the cutaneous silent period response across multiple extensor and flexor muscles of the upper limb, and 2) to secondarily investigate the influence of stimulation site on this nociceptive reflex response...
2018: PloS One
https://www.readbyqxmd.com/read/29683406/influence-of-anxiety-and-alexithymia-on-brain-activations-associated-with-the-perception-of-others-pain-in-autism
#10
Amandine Lassalle, Nicole R Zürcher, Carlo A Porro, Francesca Benuzzi, Loyse Hippolyte, Eric Lemonnier, Jakob Åsberg Johnels, Nouchine Hadjikhani
The circumstances under which empathy is altered in ASD remain unclear, as previous studies did not systematically find differences in brain activation between ASD and controls in empathy-eliciting paradigms, and did not always monitor whether differences were primarily due to ASD "per se", or to conditions overlapping with ASD, such as alexithymia and anxiety. Here, we collected fMRI data from 47 participants (22 ASD) viewing pictures depicting hands and feet of unknown others in painful, disgusting, or neutral situations...
May 7, 2018: Social Neuroscience
https://www.readbyqxmd.com/read/29671874/pain-assessment-by-pupil-dilation-reflex-in-response-to-noxious-stimulation-in-anaesthetized-adults
#11
D Wildemeersch, N Peeters, V Saldien, M Vercauteren, G Hans
BACKGROUND: In response to noxious stimulation, pupillary dilation reflex (PDR) occurs even in anaesthetized patients. The aim of the study was to evaluate the ability of pupillometry with an automated increasing stimulus intensity to monitor intraoperative opioid administration. METHODS: Thirty-four patients undergoing elective surgery were enrolled. Induction by propofol anaesthesia was increased progressively until the sedation depth criteria (SeD) were attained...
April 19, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29669562/comfort-in-palliative-sedation-compas-a-transdisciplinary-mixed-method-study-protocol-for-linking-objective-assessments-to-subjective-experiences
#12
Stefaan Six, Steven Laureys, Jan Poelaert, Johan Bilsen, Peter Theuns, Reginald Deschepper
BACKGROUND: In case of untreatable suffering at the end of life, palliative sedation may be chosen to assure comfort by reducing the patient's level of consciousness. An important question here is whether such sedated patients are completely free of pain. Because these patients cannot communicate anymore, caregivers have to rely on observation to assess the patient's comfort. Recently however, more sophisticated techniques from the neurosciences have shown that sometimes consciousness and pain are undetectable with these traditional behavioral methods...
April 18, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29655977/dexmedetomidine-or-fentanyl-cardiovascular-stability-and-analgesia-during-propofol-ketamine-total-intravenous-anaesthesia-in-experimental-pigs
#13
Andreas Lervik, Joanna Raszplewicz, Birgit Ranheim, Susanna Solbak, Simen F Toverud, Henning A Haga
OBJECTIVE: To compare cardiovascular function and response to nociception during total intravenous anaesthesia in pigs with propofol, ketamine and either dexmedetomidine or fentanyl administered as a continuous infusion. STUDY DESIGN: Blinded, randomized, balanced, crossover study ANIMALS: Eight immunocastrated male, mixed breed pigs with a mean ± standard deviation body weight of 26.4 ± 1.9 kg for dexmedetomidine and 27.5 ± 3.8 kg for fentanyl treatment...
May 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29601275/effects-of-conversational-hypnosis-on-relative-parasympathetic-tone-and-patient-comfort-during-axillary-brachial-plexus-blocks-for-ambulatory-upper-limb-surgery-a-quasiexperimental-pilot-study
#14
Emmanuel Boselli, Hervé Musellec, Franck Bernard, Nicolas Guillou, Pierre Hugot, Caroline Augris-Mathieu, Nathalie Diot-Junique, Lionel Bouvet, Bernard Allaouchiche
This two-center quasiexperimental pilot study was to determine the effect of conversational hypnosis on patient comfort and parasympathetic tone, which may represent a quantitative measure of hypnotic depth, during regional anesthesia. The patients received conversational hypnosis in one center and oral premedication in the other. The patients' subjective comfort (0-10 rating scale) and objective parasympathetic tone, as assessed by the Analgesia/Nociception Index (ANI), were measured before and after regional anesthesia...
April 2018: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/29568123/non-instrumental-clinical-monitoring-does-not-guarantee-an-adequate-course-of-general-anesthesia-a-prospective-clinical-study
#15
Katarzyna Szostakiewicz, Zbigniew Rybicki, Dariusz Tomaszewski
BACKGROUND: Clinical monitoring is the most common method of adjusting the appropriate level of general anesthesia. However, episodes of intraoperative awareness (AWR) are still reported, suggesting that clinical observations may not be sufficient in some cases. The objective of this study was to compare the efficacy of clinical and instrumental neuromonitoring with auditory evoked potentials (AEP) in an intraoperative analysis of the proper level of general anesthesia. METHODS: Patients scheduled for elective surgery were randomly divided into two groups...
March 21, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29469163/a-method-for-characterising-human-intervertebral-disc-glycosaminoglycan-disaccharides-using-liquid-chromatography-mass-spectrometry-with-multiple-reaction-monitoring
#16
X Liu, D Krishnamoorthy, L Lin, P Xue, F Zhang, L Chi, R J Linhardt, J C Iatridis
Intervertebral disc (IVD) degeneration results in the depletion of proteoglycans and glycosaminoglycans (GAGs), which can lead to structural and mechanical loss of IVD function, ingrowth of nociceptive nerve fibres and eventually discogenic pain. Specific GAG types as well as their disaccharide patterns can be predictive of disease and degeneration in several tissues but have not been comprehensively studied within the IVD. A highly sensitive mass spectrometry based technique with multiple reaction monitoring (MRM) was used to provide characterisation of chondroitin sulphate (CS), hyaluronic acid (HA), heparan sulphate (HS) and their disaccharide sulphation patterns across different anatomical regions of human IVDs...
February 22, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29445230/investigation-of-biomarkers-alterations-after-an-acute-tissue-trauma-in-human-trapezius-muscle-using-microdialysis
#17
Line Bay Sørensen, Parisa Gazerani, Karin Wåhlén, Nazdar Ghafouri, Björn Gerdle, Bijar Ghafouri
Alterations in muscle milieu are suggested as important activity of peripheral drive in patients with chronic musculoskeletal pain (CMP). Microdialysis (MD) has been used in monitoring altered metabolic response pattern in muscles. However, the insertion of MD probe causes a local tissue trauma. Whether and how metabolites in trapezius muscle are affected by acute tissue trauma is unknown. Hence, this study investigated the metabolic response and nociceptive reaction of the tissue following MD probe insertion in patients with CMP and healthy individuals...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319607/longitudinal-resting-state-functional-magnetic-resonance-imaging-in-a-mouse-model-of-metastatic-bone-cancer-reveals-distinct-functional-reorganizations-along-a-developing-chronic-pain-state
#18
David Buehlmann, Joanes Grandjean, Jael Xandry, Markus Rudin
Functional neuroimaging has emerged as attractive option for characterizing pain states complementing behavioral readouts or clinical assessment. In particular, resting-state functional magnetic resonance imaging (rs-fMRI) enables monitoring of functional adaptations across the brain, for example, in response to chronic nociceptive input. We have used rs-fMRI in a mouse model of chronic pain from breast cancer-derived tibial bone metastases to identify pain-induced alterations in functional connectivity. Combined assessment of behavioral readouts allowed for defining a trajectory as model function for extracting pain-specific functional connectivity changes from the fMRI data reflective of a chronic pain state...
April 2018: Pain
https://www.readbyqxmd.com/read/29318860/-effect-of-transcutaneous-acupoint-electrical-stimulation-on-hemodynamic-fluctuation-caused-by-loosing-tourniquet-in-elderly-patients-undergoing-knee-joint-replacement
#19
Han-Sheng Liang, Yi Feng
OBJECTIVE: To observe the effect of transcutaneous acupoint electrical stimulation (TAES) on hemodynamic fluctuation caused by loosing tourniquet in the elderly patients undergoing knee joint replacement. METHODS: A total of 60 ASA (America Society Anesthesiologist) I or II elderly patients for elective knee joint replacement surgery were randomly divided into control group (30 cases) and TAES group (30 cases). Patients of both groups were treated by intravenous anesthesia, and monitored with bispectral index (BIS, between 45-60) for anesthesia depth, stroke volume variation (SVV) for fluid management, mean arterial pressure (MAP) and cardiac index (CI) for hemodynamic fluctuation evaluation, and with analgesia nociception index (ANI, between 50-70) for remifentanil dosage adjustment...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29216820/comparison-of-the-effect-of-different-infusion-rates-of-sufentanil-on-surgical-stress-index-during-cranial-pinning-in-children-under-general-anaesthesia-a-randomized-controlled-study
#20
In-Kyung Song, Sang-Hwan Ji, Eun-Hee Kim, Ji-Hyun Lee, Jin-Tae Kim, Hee-Soo Kim
BACKGROUND: Surgical stress index (SSI) is an established indicator for intraoperative nociception. Opioids are used to block stimulus of cranial pinning in neurosurgery. We investigated the effect of different infusion rates of sufentanil on SSI during cranial pinning in children under general anaesthesia. METHODS: Forty-nine children (2-12 years of age) underwent neurosurgery with pinning. The children were randomized into three groups based on the rate of sufentanil infusion: 0...
December 8, 2017: BMC Anesthesiology
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