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https://www.readbyqxmd.com/read/28087991/an-exceptionally-selective-dna-cooperatively-binding-two-ca2-ions
#1
Wenhu Zhou, Runjhun Saran, Po-Jung Jimmy Huang, Jinsong Ding, Juewen Liu
Ca2+ is a highly important metal ion in biology and in the environment, leading to extensive work in developing sensors for Ca2+ detection. While many Ca2+ binding proteins are known, few nucleic acids can selectively bind Ca2+. DNA-based biosensors are attractive for its high stability and excellent programmability. Herein, we report a RNA-cleaving DNAzyme named EtNa cooperatively binding two Ca2+ ions but only one Mg2+. Four DNAzymes with known Ca2+-dependent activity were compared, and the EtNa has the best selectivity...
January 14, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28087297/inhibition-of-streptococcal-biofilm-by-hydrogen-water
#2
Jinkyung Kim, Heon-Jin Lee, Su-Hyung Hong
OBJECTIVES: The accumulation of oral bacterial biofilm is the main etiological factor of oral diseases. Recently, electrolyzed hydrogen-rich water (H-water) has been shown to act as an effective antioxidant by reducing oxidative stress. In addition to this general health benefit, H-water has antibacterial activity for disease-associated oral bacteria. However, little is known about the effect of H-water on oral bacterial biofilm. The objective of this study was to confirm the effect of H-water on streptococcal biofilm formation...
January 10, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28086949/nek2-promotes-aerobic-glycolysis-in-multiple-myeloma-through-regulating-splicing-of-pyruvate-kinase
#3
Zhimin Gu, Jiliang Xia, Hongwei Xu, Ivana Frech, Guido Tricot, Fenghuang Zhan
BACKGROUND: Aerobic glycolysis, a hallmark of cancer, is characterized by increased metabolism of glucose and production of lactate in normaxia. Recently, pyruvate kinase M2 (PKM2) has been identified as a key player for regulating aerobic glycolysis and promoting tumor cell proliferation and survival. METHODS: Tandem affinity purification followed up by mass spectrometry (TAP-MS) and co-immunoprecipitation (Co-IP) were used to study the interaction between NIMA (never in mitosis gene A)-related kinase 2 (NEK2) and heterogeneous nuclear ribonucleoproteins (hnRNP) A1/2...
January 13, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28086891/measurement-of-electrocardiograms-in-a-bath-through-tap-water-utilizing-capacitive-coupling-electrodes-placed-outside-the-bathtub-wall
#4
Kosuke Motoi, Yasuhiro Yamakoshi, Takehiro Yamakoshi, Hiroaki Sakai, Naoto Tanaka, Ken-Ichi Yamakoshi
BACKGROUND: Taking a bath sometimes poses a risk for subjects with chronic cardiopulmonary disorders, due to the thermal effect and water pressure on his/her body. The ECG measurement would be helpful for the early recognition of abnormal cardiac beats and respiratory conditions. This paper describes a new attempt to improve on previous bathtub ECG measurement techniques that had electrodes placed inside the bathtub that were intrusive to the subjects' bathing experience. This study is concerned with the initial development of a method to measure an electrocardiogram (ECG) through tap water without conscious awareness of the presence of electrodes that are placed outside the bathtub wall...
January 11, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28080075/cognitive-outcomes-in-early-treated-adults-with-phenylketonuria-pku-a-comprehensive-picture-across-domains
#5
Liana Palermo, Tarekegn Geberhiwot, Anita MacDonald, Ellie Limback, S Kate Hall, Cristina Romani
OBJECTIVE: Phenylketonuria (PKU) is an inherited metabolic disease which affects cognitive functions due to an inability to metabolize phenylalanine which leads to the accumulation of toxic by-products (Phe) in the brain. PKU can be effectively treated with a low phenylalanine diet, but some cognitive deficits remain. Studies have reported impairments, especially for processing speed and executive functions, but there is a lack of comprehensive assessment across cognitive domains. Moreover, it is important to establish outcomes in early treated adults with PKU (AwPKU) who have better metabolic control than groups previously reported in the literature...
January 12, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28077517/two-phase-hospital-associated-outbreak-of-mycobacterium-abscessus-investigation-and-mitigation
#6
Arthur W Baker, Sarah S Lewis, Barbara D Alexander, Luke F Chen, Richard J Wallace, Barbara A Brown-Elliott, Pamela J Isaacs, Lisa C Pickett, Chetan B Patel, Peter K Smith, John M Reynolds, Jill Engel, Cameron R Wolfe, Carmelo A Milano, Jacob N Schroder, Robert D Davis, Matthew G Hartwig, Jason E Stout, Nancy Strittholt, Eileen K Maziarz, Jennifer Horan Saullo, Kevin C Hazen, Richard J Walczak, Ravikiran Vasireddy, Sruthi Vasireddy, Celeste M McKnight, Deverick J Anderson, Daniel J Sexton
BACKGROUND: Nontuberculous mycobacteria (NTM) commonly colonize municipal water and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital. METHODS: Case patients had recent hospital exposure and laboratory-confirmed colonization or infection with M. abscessus from January 2013 through December 2015. We conducted a multidisciplinary epidemiologic, field, and laboratory investigation. RESULTS: The incidence rate of M...
January 11, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28077305/in-utero-exposure-to-fluoride-and-cognitive-development-delay-in-infants
#7
L Valdez Jiménez, O D López Guzmán, M Cervantes Flores, R Costilla-Salazar, J Calderón Hernández, Y Alcaraz Contreras, D O Rocha-Amador
The objective of this study was to evaluate the association between in utero exposure to fluoride (F) and Mental and Psychomotor Development (MDI and PDI) evaluated through the Bayley Scale of Infant Development II (BSDI-II) in infants. The sample included 65 mother-infant pairs. Environmental exposure to F was quantified in tap and bottled water samples and F in maternal urine was the biological exposure indicator; samples were collected during the 1st, 2nd and 3rd trimester of pregnancy. The mean values of F in tap water for the 1st, 2nd and 3rd trimester were 2...
January 8, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28077292/general-and-specific-factors-in-the-processing-of-faces
#8
Roeland J Verhallen, Jenny M Bosten, Patrick T Goodbourn, Adam J Lawrance-Owen, Gary Bargary, J D Mollon
The ability to recognize faces varies considerably between individuals, but does performance co-vary for tests of different aspects of face processing? For 397 participants (of whom the majority were university students) we obtained scores on the Mooney Face Test, Glasgow Face Matching Test (GFMT), Cambridge Face Memory Test (CFMT) and Composite Face Test. Overall performance was significantly correlated for each pair of tests, and we suggest the term f for the factor underlying this pattern of positive correlations...
January 7, 2017: Vision Research
https://www.readbyqxmd.com/read/28074887/association-analysis-of-dyslexia-candidate-genes-in-a-dutch-longitudinal-sample
#9
Amaia Carrion-Castillo, Ben Maassen, Barbara Franke, Angelien Heister, Marlies Naber, Aryan van der Leij, Clyde Francks, Simon E Fisher
Dyslexia is a common specific learning disability with a substantive genetic component. Several candidate genes have been proposed to be implicated in dyslexia susceptibility, such as DYX1C1, ROBO1, KIAA0319, and DCDC2. Associations with variants in these genes have also been reported with a variety of psychometric measures tapping into the underlying processes that might be impaired in dyslexic people. In this study, we first conducted a literature review to select single nucleotide polymorphisms (SNPs) in dyslexia candidate genes that had been repeatedly implicated across studies...
January 11, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28074268/cognitive-deficits-in-patients-with-a-chronic-vestibular-failure
#10
Pauline Popp, Melanie Wulff, Kathrin Finke, Maxine Rühl, Thomas Brandt, Marianne Dieterich
Behavioral studies in rodents and humans have demonstrated deficits of spatial memory and orientation in bilateral vestibular failure (BVF). Our aim was to explore the functional consequences of chronic vestibular failure on different cognitive domains including spatial as well as non-spatial cognitive abilities. Sixteen patients with a unilateral vestibular failure (UVF), 18 patients with a BVF, and 17 healthy controls (HC) participated in the study. To assess the cognitive domains of short-term memory, executive function, processing speed and visuospatial abilities the following tests were used: Theory of Visual Attention (TVA), TAP Alertness and Visual Scanning, the Stroop Color-Word, and the Corsi Block Tapping Test...
January 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28073641/effect-of-surfactants-on-the-aggregation-and-sedimentation-of-zinc-oxide-nanomaterial-in-natural-water-matrices
#11
Xuankun Li, Minoru Yoneda, Yoko Shimada, Yasuto Matsui
The wide application of surfactants and engineered nanomaterials (ENMs) in industrial and consumer products lead to the high possibility of their co-presence in natural water environment, making it important to study the effect of surfactants on the environmental behavior and fate of ENMs. In this work, we selected an anionic sodium dodecyl sulfate (SDS) and a nonionic nonylphenol ethoxylate (NPEO, Tergitol NP-9) to study their effects on the aggregation and sedimentation of a 20nm ZnO ENM in different water matrices...
January 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28073630/adona-and-perfluoroalkylated-substances-in-plasma-samples-of-german-blood-donors-living-in-south-germany
#12
Hermann Fromme, Mandy Wöckner, Eike Roscher, Wolfgang Völkel
Perfluorinated compounds are fully fluorinated anthropogenic substances that have been used in various products, applications, and industrial processes. Due to their persistence and toxic effects, some of them are restricted, and therefore replacement products have been developed. The aim of the study was to quantify the body burden of different perfluorinated substances in two adult populations living close to or about 80km apart from a former perfluorooctanoate (PFOA) production plant who are exposed via drinking water, and in a control population...
January 4, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28072916/a-preliminary-study-examining-women-s-physical-health-and-nonmedical-prescription-opioid-use-in-a-recovering-framework
#13
Katherine R Marks, Carl G Leukefeld
BACKGROUND: There is a growing need for research on women recovering from nonmedical prescription opioid use. A paradigm shift is to focus on wellness and factors that support, rather than hinder, recovering women. For example, although physical health is impacted by nonmedical prescription opioid use, improved health may be a strength-based factor among recovering women. The aim of this preliminary study was to examine physical health in a recovering framework as women begin recovering from nonmedical prescription opiate use...
January 10, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28072798/reliability-and-safety-of-contra-lateral-oblique-view-for-interlaminar-epidural-needle-placement
#14
Richard Derby, Irina Melnik, Jongwoo Choi, Sang-Hoon Lee, Jeong-Eun Lee
Cord trauma is a risk with a cervical and thoracic interlaminar epidural approach to the epidural space. Intermittent lateral fluoroscopic imaging to detect needle depth is often cumbersome and may be difficult to interpret. In comparison, the contra-lateral oblique (CLO) fluoroscopic view is efficient and easy to interpret. However, the in vivo reliability and safety of this technique has not been formally investigated.The senior author collected fluoroscopic images on 278 consecutive patients undergoing an interlaminar epidural block at the T1-T2 level performed using a 17 gauge Tuohy needle...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28070588/a-silica-based-sers-chip-for-rapid-and-ultrasensitive-detection-of-fluoride-ions-triggered-by-a-cyclic-boronate-ester-cleavage-reaction
#15
Jian Zhang, Lifang He, Peirong Chen, Chao Tian, Jianping Wang, Bianhua Liu, Changlong Jiang, Zhongping Zhang
Chemical sensing for the convenient detection of trace aqueous fluoride ions (F(-)) has been widely explored with the use of various sensing materials and techniques. It still remains a challenge to achieve ultrasensitive but simple, rapid, and inexpensive detection of F(-) for environmental monitoring and protection. Here we reported a novel surface-enhanced Raman scattering (SERS) nanosensor, fluorescein phenylboronic acid covalently linked to 1,4-dimercapto-2,3-butanediol modified Au@Ag NPs by a cyclic boronate ester (Flu-PBA-Diol-Au@Ag NPs), for the rapid and ultrasensitive detection of F(-)...
January 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28070256/consumer-perception-and-preference-of-drinking-water-sources
#16
Seyed Ali Sajjadi, Vali Alipour, Mohammad Matlabi, Hamed Biglari
INTRODUCTION: Understanding consumer perception of drinking water can contribute to improvements in water management and consumer satisfaction. The aim of this study was to assess the consumer perception of tap water quality and other drinking water sources in Gonabad as a small semiarid city. METHODS: This study was performed in autumn and winter 2013. For collection data a researcher-made a questionnaire consisting of nine questions, based on demographic information prepared...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28069938/crystal-structure-and-mechanistic-basis-of-a-functional-homolog-of-the-antigen-transporter-tap
#17
Anne Nöll, Christoph Thomas, Valentina Herbring, Tina Zollmann, Katja Barth, Ahmad Reza Mehdipour, Thomas M Tomasiak, Stefan Brüchert, Benesh Joseph, Rupert Abele, Vincent Oliéric, Meitian Wang, Kay Diederichs, Gerhard Hummer, Robert M Stroud, Klaas M Pos, Robert Tampé
ABC transporters form one of the largest protein superfamilies in all domains of life, catalyzing the movement of diverse substrates across membranes. In this key position, ABC transporters can mediate multidrug resistance in cancer therapy and their dysfunction is linked to various diseases. Here, we describe the 2.7-Å X-ray structure of heterodimeric Thermus thermophilus multidrug resistance proteins A and B (TmrAB), which not only shares structural homology with the antigen translocation complex TAP, but is also able to restore antigen processing in human TAP-deficient cells...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28068561/classifying-the-variability-in-impact-and-active-peak-vertical-ground-reaction-forces-during-running-using-dfa-and-arfima-models
#18
Samantha L Winter, John H Challis
The vertical ground reaction force (VGRF) during rear-foot striking running typically exhibits peaks referred to as the impact peak and the active peak; their timings and magnitudes have been implicated in injury. Identifying the structure of time-series can provide insight into associated control processes. The purpose here was to detect long-range correlations associated with the time from first contact to impact peak (TIP) and active peak (TAP); and the magnitudes of impact (IPM) and active peaks (APM) using a Detrended Fluctuation Analysis, and Auto-Regressive Fractionally Integrated Moving Average models...
January 6, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28067549/exploring-visuospatial-abilities-and-their-contribution-to-constructional-abilities-and-nonverbal-intelligence
#19
Luigi Trojano, Mattia Siciliano, Chiara Cristinzio, Dario Grossi
The present study aimed at exploring relationships among the visuospatial tasks included in the Battery for Visuospatial Abilities (BVA), and at assessing the relative contribution of different facets of visuospatial processing on tests tapping constructional abilities and nonverbal abstract reasoning. One hundred forty-four healthy subjects with a normal score on Mini Mental State Examination completed the BVA plus Raven's Coloured Progressive Matrices and Constructional Apraxia test. We used Principal Axis Factoring and Parallel Analysis to investigate relationships among the BVA visuospatial tasks, and performed regression analyses to assess the visuospatial contribution to constructional abilities and nonverbal abstract reasoning...
January 9, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28067371/high-efficiency-hydrodynamic-bacterial-electrotransformation
#20
Paulo A Garcia, Zhifei Ge, Laura E Kelley, Steven J Holcomb, Cullen R Buie
Synthetic biology holds great potential for addressing pressing challenges for mankind and our planet. One technical challenge in tapping into the full potential of synthetic biology is the low efficiency and low throughput of genetic transformation for many types of cells. In this paper, we discuss a novel microfluidic system for improving bacterial electrotransformation efficiency and throughput. Our microfluidic system is comprised of non-uniform constrictions in microchannels to facilitate high electric fields with relatively small applied voltages to induce electroporation...
January 9, 2017: Lab on a Chip
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