Si-Jie Dai, Yu-Ying Shao, Yang Zheng, Jin-Yi Sun, Zhi-Sheng Li, Jia-Ying Shi, Meng-Qi Yan, Xiao-Yun Qiu, Ceng-Lin Xu, Wan-Sang Cho, Masahiro Nishibori, Sihyeong Yi, Seung Bum Park, Yi Wang, Zhong Chen
Epilepsy is not well controlled by current anti-seizure drugs (ASDs). High mobility group box 1 (HMGB1) is a DNA-binding protein in the nucleus regulating transcriptional activity and maintaining chromatin structure and DNA repair. In epileptic brains, HMGB1 is released by activated glia and neurons, interacting with various receptors like Toll-like receptor 4 (TLR4) and downstream glutamatergic NMDA receptor, thus enhancing neural excitability. But there is a lack of small-molecule drugs targeting the HMGB1-related pathways...
April 19, 2023: Acta Pharmacologica Sinica