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https://www.readbyqxmd.com/read/20737263/effect-of-ezetimibe-simvastatine-over-endothelial-dysfunction-in-dyslipidemic-patients-assessment-by-13n-ammonia-positron-emission-tomography
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Erick Alexanderson, Leonardo García-Rojas, Moisés Jiménez, Rodrigo Jácome, Rodrigo Calleja, Alfonso Martínez, Juan M Ochoa, Aloha Meave, Graciela Alexanderson
BACKGROUND: Dyslipidemias constitute an independent risk factor for the development of atherogenesis and they also predispose to the development of endothelial dysfunction (ED). Using PET with (13)N-ammonia, it is possible to quantify myocardial blood flow (MBF) in mL/min/g and to quantitatively evaluate ED. With the use of lipid lowering therapy it is possible to reduce ED and increase the MBF and the endothelial-dependent vasodilation index (ENDEVI). In this study, we aimed to evaluate with (13)N-ammonia PET the benefic effects of the combined treatment ezetimibe/simvastatine on the endothelial function of dyslipidemic patients after 8 weeks of treatment...
December 2010: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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