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https://www.readbyqxmd.com/read/28429832/a-genetic-risk-score-that-includes-common-type-2-diabetes-risk-variants-is-associated-with-gestational-diabetes
#1
Vivian K Kawai, Rebecca T Levinson, Abiodun Adefurin, Daniel Kurnik, Sarah P Collier, Douglas Conway, C Michael Stein
OBJECTIVE: Gestational diabetes (GDM) is characterized by maternal glucose intolerance that manifests during pregnancy. Because GDM resembles type 2 diabetes (T2DM), shared genetic predisposition is likely but has not been established. We tested the hypothesis that a genetic risk score (GRS) that included variants known to be associated with T2DM is associated with GDM. STUDY DESIGN: We conducted a case-control study using the Vanderbilt Medical Center biobank (BioVU), and calculated a simple-count GRS using 34 variants previously associated with T2DM or fasting glucose in the general population, or with GDM or glucose intolerance in pregnancy...
April 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28427944/creating-a-global-acute-care-surgery-fellowship-to-meet-international-need
#2
Amina I Merchant, Camila B Walters, Julie Valenzuela, Kelly A McQueen, Addison K May
INTRODUCTION: Existing Acute Care Surgery (ACS) fellowships are positioned to develop well-trained surgeons with specific skills to facilitate improvements in care delivery in Global ACS. Many resident and fellowship programs offer clinical electives that expose trainees to operative experiences, exposing trainees to the needs in resource-challenged settings. However, most lack a focus on long-term development and research designed to enhance the country's local skills, capability, and capacity...
April 17, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28427027/multisensory-temporal-function-and-eeg-complexity-in-patients-with-epilepsy-and-psychogenic-nonepileptic-events
#3
Jean-Paul Noel, LeAnne Kurela, Sarah H Baum, Hong Yu, Joseph S Neimat, Martin J Gallagher, Mark Wallace
Cognitive and perceptual comorbidities frequently accompany epilepsy and psychogenic nonepileptic events (PNEE). However, and despite the fact that perceptual function is built upon a multisensory foundation, little knowledge exists concerning multisensory function in these populations. Here, we characterized facets of multisensory processing abilities in patients with epilepsy and PNEE, and probed the relationship between individual resting-state EEG complexity and these psychophysical measures in each patient...
April 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28402386/strandscript-evaluation-of-illumina-genotyping-array-design-and-strand-correction
#4
Jing Wang, David C Samuels, Yu Shyr, Yan Guo
Summary: After the introduction of high-throughput sequencing, genotyping arrays continue to be a viable source for conducting large-scale genetic studies. Currently, Illumina is one of the largest genotyping array manufacturers. One technical issue that has always plagued the post-processing of Illumina genotyping array data is the strand definition. Against convention, Illumina uses their own definition of strand, which is inconsistent with the standard reference forward and reverse definition...
April 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28379727/accelerating-precision-drug-development-and-drug-repurposing-by-leveraging-human-genetics
#5
Jill M Pulley, Jana K Shirey-Rice, Robert R Lavieri, Rebecca N Jerome, Nicole M Zaleski, David M Aronoff, Lisa Bastarache, Xinnan Niu, Kenneth J Holroyd, Dan M Roden, Eric P Skaar, Colleen M Niswender, Lawrence J Marnett, Craig W Lindsley, Leeland B Ekstrom, Alan R Bentley, Gordon R Bernard, Charles C Hong, Joshua C Denny
The potential impact of using human genetic data linked to longitudinal electronic medical records on drug development is extraordinary; however, the practical application of these data necessitates some organizational innovations. Vanderbilt has created resources such as an easily queried database of >2.6 million de-identified electronic health records linked to BioVU, which is a DNA biobank with more than 230,000 unique samples. To ensure these data are used to maximally benefit and accelerate both de novo drug discovery and drug repurposing efforts, we created the Accelerating Drug Development and Repurposing Incubator, a multidisciplinary think tank of experts in various therapeutic areas within both basic and clinical science as well as experts in legal, business, and other operational domains...
April 2017: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/28374640/implementation-of-image-guided-cochlear-implant-programming-at-a-distant-site
#6
Theodore R McRackan, Jack H Noble, Eric P Wilkinson, Dawna Mills, Mary S Dietrich, Benoit M Dawant, Rene H Gifford, Robert F Labadie
Our objective was to prospectively evaluate implementation of a new cochlear implant (CI) mapping technique, image-guided cochlear implant programming (IGCIP), at a site distant to the site of development. IGCIP consists of identifying the geometric relationship between CI electrodes and the modiolus and deactivating electrodes that interfere with neighboring electrodes. IGCIP maps for 17 ears of 15 adult CI patients were developed at a central image-processing center, Vanderbilt, and implemented at a distant tertiary care center, House Ear Institute...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28368969/parent-reported-strengths-in-children-with-autism-spectrum-disorders-at-the-time-of-an-interdisciplinary-diagnostic-evaluation
#7
Thusa Sabapathy, Nirupama Madduri, Alexis Deavenport-Saman, Irina Zamora, Sheree M Schrager, Douglas L Vanderbilt
OBJECTIVE: Parents of children with autism spectrum disorders (ASD) often focus on concerns in discussions with health care providers. However, studying child strengths and positive parental attributions is an emerging area of focus and not often highlighted in many studies with children with ASD. The objective of this study was to identify parent-reported strengths in a sample of children with ASD. METHODS: This was a qualitative study of parent report of strengths in clinical notes with children between the ages 3 and 8 presenting for a team diagnostic evaluation and meeting the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV-Text Revision (TR) or DSM-V diagnostic criteria for ASD...
April 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28365244/the-cam-icu-has-now-a-french-official-version-the-translation-process-of-the-2014-updated-complete-training-manual-of-the-confusion-assessment-method-for-the-intensive-care-unit-in-french-cam-icu-fr
#8
Gérald Chanques, Océane Garnier, Julie Carr, Matthieu Conseil, Audrey de Jong, Christine M Rowan, E Wesley Ely, Samir Jaber
INTRODUCTION: Delirium is common in Intensive-Care-Unit (ICU) patients but under-recognized by bed-side clinicians when not using validated delirium-screening tools. The Confusion-Assessment-Method for the ICU (CAM-ICU) has demonstrated very good psychometric properties, and has been translated into many different languages though not into French. We undertook this opportunity to describe the translation process. MATERIAL-AND-METHODS: The translation was performed following recommended guidelines...
March 29, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28361393/limited-evidence-of-individual-differences-in-holistic-processing-in-different-versions-of-the-part-whole-paradigm
#9
Mackenzie A Sunday, Jennifer J Richler, Isabel Gauthier
The part-whole paradigm was one of the first measures of holistic processing and it has been used to address several topics in face recognition, including its development, other-race effects, and more recently, whether holistic processing is correlated with face recognition ability. However the task was not designed to measure individual differences and it has produced measurements with low reliability. We created a new holistic processing test designed to measure individual differences based on the part-whole paradigm, the Vanderbilt Part Whole Test (VPWT)...
March 30, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28357519/low-working-memory-rather-than-adhd-symptoms-predicts-poor-academic-achievement-in-school-aged-children
#10
Ashley N Simone, David J Marks, Anne-Claude Bédard, Jeffrey M Halperin
This study examined whether working memory (WM), inattentive symptoms, and/or hyperactive/impulsive symptoms significantly contributed to academic, behavioral, and global functioning in 8-year-old children. One-hundred-sixty 8-year-old children (75.6% male), who were originally recruited as preschoolers, completed subtests from the Wechsler Intelligence Scale for Children-Fourth Edition, Integrated and Wechsler Individual Achievement Test-Second Edition to assess WM and academic achievement, respectively. Teachers rated children's academic and behavioral functioning using the Vanderbilt Rating Scale...
March 29, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28335839/apolipoprotein-l1-variants%C3%A2-and-blood-pressure-traits-in%C3%A2-african-americans
#11
Girish N Nadkarni, Geneviève Galarneau, Stephen B Ellis, Rajiv Nadukuru, Jinglan Zhang, Stuart A Scott, Claudia Schurmann, Rongling Li, Laura J Rasmussen-Torvik, Abel N Kho, M Geoffrey Hayes, Jennifer A Pacheco, Teri A Manolio, Rex L Chisholm, Dan M Roden, Joshua C Denny, Eimear E Kenny, Erwin P Bottinger
BACKGROUND: African Americans (AA) are disproportionately affected by hypertension-related health disparities. Apolipoprotein L1 (APOL1) risk variants are associated with kidney disease in hypertensive AAs. OBJECTIVES: This study assessed the APOL1 risk alleles' association with blood pressure traits in AAs. METHODS: The discovery cohort included 5,204 AA participants from Mount Sinai's BioMe biobank. Replication cohorts included additional BioMe (n = 1,623), Vanderbilt BioVU (n = 1,809), and Northwestern NUgene (n = 567) AA biobank participants...
March 28, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28302179/balanced-crystalloids-versus-saline-in-the-intensive-care-unit-study-protocol-for-a-cluster-randomized-multiple-crossover-trial
#12
Matthew W Semler, Wesley H Self, Li Wang, Daniel W Byrne, Jonathan P Wanderer, Jesse M Ehrenfeld, Joanna L Stollings, Avinash B Kumar, Antonio Hernandez, Oscar D Guillamondegui, Addison K May, Edward D Siew, Andrew D Shaw, Gordon R Bernard, Todd W Rice
BACKGROUND: Saline, the intravenous fluid most commonly administered to critically ill adults, contains a high chloride content, which may be associated with acute kidney injury and death. Whether using balanced crystalloids rather than saline decreases the risk of acute kidney injury and death among critically ill adults remains unknown. METHODS: The Isotonic Solutions and Major Adverse Renal Events Trial (SMART) is a pragmatic, cluster-level allocation, cluster-level crossover trial being conducted between 1 June 2015 and 30 April 2017 in five intensive care units at Vanderbilt University Medical Center in Nashville, TN, USA...
March 16, 2017: Trials
https://www.readbyqxmd.com/read/28277261/building-a-palliative-radiation-oncology-program-from-bedside-to-b-e-d
#13
Mark J Stavas, Jonathan D Pagan, Sumeeta Varma, Benjamin Li, Lisa A Kachnic
A growing body of evidence supports the integration of palliative care with standard cancer treatments. In these situations, patients often experience a better quality of life, better quality of care, decreased cost, and, in some cases, improved survival with the addition of palliative care services to traditional treatment pathways. In this manuscript, we explore the integration of radiation oncology at palliative care. First, we discuss the impetus for change at Vanderbilt University and the inception of Vanderbilt's inpatient Palliative Radiation Oncology Service at Vanderbilt...
September 13, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28266038/using-direct-antiglobulin-test-results-to-reduce-unnecessary-cold-agglutinin-testing
#14
Craig B Wilen, Garrett S Booth, Brenda J Grossman, William J Lane, Penny C Szklarski, Ronald Jackups
BACKGROUND: Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia mediated by autoantibodies that preferentially react at 4°C. Laboratory testing for cold-reactive autoantibodies is laborious and may not be ordered judiciously, particularly in patients with a negative direct antiglobulin test (DAT). We sought to determine whether a negative DAT using anti-human complement (anti-C3) rules out elevated cold agglutinin (CA) titers and the diagnosis of CAD. STUDY DESIGN AND METHODS: We performed a retrospective study of patients with a CA test performed at three major academic medical centers: Barnes-Jewish Hospital (2003-2014), Vanderbilt University Medical Center (2007-2009), and Massachusetts General Hospital (2009-2014)...
March 7, 2017: Transfusion
https://www.readbyqxmd.com/read/28263642/observer-youth-and-therapist-perspectives-on-the-alliance-in-cognitive-behavioral-treatment-for-youth-anxiety
#15
Bryce D McLeod, Michael A Southam-Gerow, Philip C Kendall
This study examined the score reliability and validity of observer- (Therapy Process Observational Coding System for Child Psychotherapy-Alliance scale [TPOCS-A]; Vanderbilt Therapeutic Alliance Scale Revised, Short Form [VTAS-R-SF]), therapist- (Therapeutic Alliance Scale for Children Therapist Version [TASC-T]), and youth-rated (Therapeutic Alliance Scale for Children Child Version [TASC-C]) alliance instruments. Youths (N = 50) aged 7-15 (Mage = 10.28 years, SD = 1.84; 88.0% Caucasian; 60.0% male) diagnosed with a principal anxiety disorder received manual-based cognitive-behavioral treatment...
March 6, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28252537/daily-lowest-hemoglobin-and-risk-of-organ-dysfunctions-in-critically-ill-patients
#16
Sarah J Hemauer, Adam J Kingeter, Xue Han, Matthew S Shotwell, Pratik P Pandharipande, Liza M Weavind
OBJECTIVES: To determine the association between hemoglobin levels and the daily risk of individual organ dysfunctions in critically ill patients. DESIGN: Post hoc analysis of prospectively collected data. SETTING: Vanderbilt University Medical Center and Saint Thomas Hospital Medical and Surgical ICUs. PATIENTS: Medical and surgical ICU patients admitted with respiratory failure or shock. INTERVENTIONS: Baseline demographic data, and detailed in-ICU and hospital data, including daily lowest hemoglobin, were collected up to hospital day 30...
May 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28248564/patient-and-therapist-perspectives-during-the-psychotherapy-termination-process-the-role-of-participation-and-exploration
#17
Margot P Weil, Michael Katz, Mark J Hilsenroth
OBJECTIVE: This study was the first to examine psychotherapy termination from both therapists' and patients' perspectives by using standardized psychotherapy process measures. Our aim was to examine whether patient participation and therapist exploration during the termination phase of treatment are related to how good and productive the session was. METHOD: The sample consisted of 30 outpatient adults who had completed the Vanderbilt Psychotherapy Process Scale-Short form (VPPS-S; Smith, Hilsenroth, Baity, & Knowles, 2003) and the Session Evaluation Questionnaire (SEQ; Stiles, 1980) during a termination-phase session...
2017: Psychodynamic Psychiatry
https://www.readbyqxmd.com/read/28245487/mitochondrial-haplogroups-affect-severity-but-not-prevalence-of-diabetic-retinopathy
#18
Jana A Bregman, David J Herren, Christopher B Estopinal, Isaac M Chocron, Paula A Harlow, Cassandra Warden, Milam A Brantley, David C Samuels
Purpose: We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroups are also associated with the risk of having DR among Caucasian patients with diabetes. Methods: Deidentified medical records for 637 Caucasian patients with diabetes (223 with DR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28225732/integrating-and-assessing-structural-competency-in-an-innovative-prehealth-curriculum-at-vanderbilt-university
#19
Jonathan M Metzl, JuLeigh Petty
PROBLEM: Structural competency is a framework for conceptualizing and addressing health-related social justice issues that emphasizes diagnostic recognition of economic and political conditions producing and racializing inequalities in health. Strategies are needed to teach prehealth undergraduate students concepts central to structural competency (e.g., structural inequity, structural racism, structural stigma) and to evaluate their impact. APPROACH: The curriculum for Vanderbilt University's innovative prehealth major in medicine, health, and society (MHS) was reshaped in 2013 to incorporate structural competency concepts and skills into undergraduate courses...
March 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28219462/the-use-of-a-computerized-provider-order-entry-alert-to-decrease-rates-of-clostridium-difficile-testing-in-young-pediatric-patients
#20
Maribeth R Nicholson, Peter N Freswick, M Cecilia Di Pentima, Li Wang, Kathryn M Edwards, Gregory J Wilson, Thomas R Talbot
BACKGROUND Infants and young children are frequently colonized with C. difficile but rarely have symptomatic disease. However, C. difficile testing remains prevalent in this age group. OBJECTIVE To design a computerized provider order entry (CPOE) alert to decrease testing for C. difficile in young children and infants. DESIGN An interventional age-targeted before-after trial with comparison group SETTING Monroe Carell Jr. Children's Hospital at Vanderbilt University, Nashville, Tennessee. PATIENTS All children seen in the inpatient or emergency room settings from July 2012 through July 2013 (pre-CPOE alert) and September 2013 through September 2014 (post-CPOE alert) INTERVENTION In August of 2013, we implemented a CPOE alert advising against testing in infants and young children based on the American Academy of Pediatrics recommendations with an optional override...
February 21, 2017: Infection Control and Hospital Epidemiology
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