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https://www.readbyqxmd.com/read/29788403/evaluating-previous-antibiotic-use-as-a-risk-factor-for-acute-gastroenteritis-among-children-in-davidson-county-tennessee-2014-2015
#1
Jonathan M Kolsin, Benjamin A Lopman, Daniel C Payne, Mary E Wikswo, John R Dunn, Natasha B Halasa, Aron J Hall
Background: Epidemiologic studies that evaluate the relationship between previous antibiotic use and acute gastroenteritis (AGE) in the pediatric population are currently lacking. Methods: We analyzed inpatient and outpatient children with AGE and healthy controls from Vanderbilt University Medical Center between December 1, 2014, and November 30, 2015. The following 4 outcome groups were defined: overall AGE, norovirus-associated AGE, rotavirus-associated AGE, and nonnorovirus/nonrotavirus AGE...
May 19, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29786450/atrial-fibrillation-symptom-clusters-and-associated-clinical-characteristics-and-outcomes-a-cross-sectional-secondary-data-analysis
#2
Megan Streur, Sarah J Ratcliffe, David Callans, M Benjamin Shoemaker, Barbara Riegel
BACKGROUND: Symptom clusters among adults with atrial fibrillation have previously been identified but no study has examined the relationship between symptom clusters and outcomes. AIMS: The purpose of this study was to identify atrial fibrillation-specific symptom clusters, characterize individuals with each cluster, and determine whether symptom cluster membership is associated with healthcare utilization. METHODS: This was a cross-sectional secondary data analysis of 1501 adults from the Vanderbilt Atrial Fibrillation Registry with verified atrial fibrillation...
May 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29762776/commentary-neurological-surgery-at-vanderbilt-university-1873-to-present
#3
Patrick D Kelly, Scott L Zuckerman, Lola B Chambless, Timothy P Schoettle, John C Wellons, Reid C Thompson
No abstract text is available yet for this article.
May 12, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29759664/angiographic-efficacy-of-the-atriclip-left-atrial-appendage-exclusion-device-placed-by-minimally-invasive-thoracoscopic-approach
#4
Christopher R Ellis, Sam G Aznaurov, Neel J Patel, Jennifer R Williams, Kim Lori Sandler, Steven J Hoff, Stephen K Ball, S Patrick Whalen, John Jeffrey Carr
OBJECTIVES: This study sought to assess long-term left atrial appendage (LAA) closure efficacy of the Atriclip applied via totally thoracoscopic (TT) approach with computed tomographic angiography. BACKGROUND: LAA closure is associated with a low risk for atrial fibrillation-related embolic stroke. The Atriclip exclusion device allows epicardial LAA closure, avoiding the need for post-operative oral anticoagulation. Previous data with Atriclip during open chest procedures show a high efficacy rate of closure >95%...
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29753159/defining-incidence-and-risk-factors-for-catheter-associated-bloodstream-infections-in-an-outpatient-adult-hematopoietic-cell-transplant-program
#5
Marissa K McDonald, Kathryn A Culos, Katie S Gatwood, Caleb Prow, Heidi Chen, Bipin N Savani, Michael Byrne, Adetola A Kassim, Brian G Engelhardt, Madan Jagasia, Gowri Satyanarayana
BACKGROUND: Allogeneic hematopoietic cell transplant (HCT) patients are at an increased risk of developing central line-associated bloodstream infections (CLABSIs) due to prolonged periods of myelosuppression, immunosuppression, and indwelling catheter days. CLABSIs are among the most serious complications in HCT recipients and can lead to prolonged hospitalizations, intensive care unit (ICU) admissions, lengthy antimicrobial therapies, and increased mortality. There is a lack of data regarding the incidence and risk factors associated with the development of CLABSIs in the HCT population undergoing outpatient transplantation...
May 9, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29751968/maintaining-oncologic-integrity-with-minimally-invasive-resection-of-pediatric-embryonal-tumors
#6
Hannah M Phelps, Gregory D Ayers, Josephine M Ndolo, Hannah L Dietrich, Katherine D Watson, Melissa A Hilmes, Harold N Lovvorn
BACKGROUND: Embryonal tumors arise typically in infants and young children and are often massive at presentation. Operative resection is a cornerstone in the multimodal treatment of embryonal tumors but potentially disrupts therapeutic timelines. When used appropriately, minimally invasive surgery can minimize treatment delays. The oncologic integrity and safety attainable with minimally invasive resection of embryonal tumors, however, remains controversial. METHODS: Query of the Vanderbilt Cancer Registry identified all children treated for intracavitary, embryonal tumors during a 15-year period...
May 8, 2018: Surgery
https://www.readbyqxmd.com/read/29747827/b-type-natriuretic-peptide-levels-and-mortality-in-patients-with-and-without-heart-failure
#7
Michelle K York, Deepak K Gupta, Cassandra F Reynolds, Eric Farber-Eger, Quinn S Wells, Katherine N Bachmann, Meng Xu, Frank E Harrell, Thomas J Wang
BACKGROUND: Circulating B-type natriuretic peptide (BNP) concentrations strongly predict mortality in patients with heart failure (HF). Both cardiac and extracardiac stimuli influence BNP levels, suggesting that BNP might have similar prognostic value in patients without HF. OBJECTIVES: The aim of this study was to compare the prognostic value of BNP between patients with and those without HF. METHODS: Using the Vanderbilt University Medical Center electronic health record, 30,487 patients (median age 63 years, 50% men, 17% black, 38% with HF) who had a first plasma BNP measurement between 2002 and 2013, with follow-up through 2015, were studied...
May 15, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29742757/evaluation-of-a-novel-system-to-enhance-clinicians-recognition-of-preadmission-adverse-drug-reactions
#8
Joshua C Smith, Qingxia Chen, Joshua C Denny, Dan M Roden, Kevin B Johnson, Randolph A Miller
BACKGROUND:  Often unrecognized by providers, adverse drug reactions (ADRs) diminish patients' quality of life, cause preventable admissions and emergency department visits, and increase health care costs. OBJECTIVE:  This article evaluates whether an automated system, the Adverse Drug Effect Recognizer (ADER), could assist clinicians in detecting and addressing inpatients' ongoing preadmission ADRs. METHODS:  ADER uses natural language processing to extract patients' medications, findings, and past diagnoses from admission notes...
April 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29732569/consider-the-source-children-link-the-accuracy-of-text-based-sources-to-the-accuracy-of-the-author
#9
Kimberly E Vanderbilt, Karlena D Ochoa, Jayd Heilbrun
The present research investigated whether young children link the accuracy of text-based information to the accuracy of its author. Across three experiments, three- and four-year-olds (N = 231) received information about object labels from accurate and inaccurate sources who provided information both in text and verbally. Of primary interest was whether young children would selectively rely on information provided by more accurate sources, regardless of the form in which the information was communicated. Experiment 1 tested children's trust in text-based information (e...
May 6, 2018: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/29727320/creating-a-quality-improvement-course-for-undergraduate-medical-education-practice-what-you-teach
#10
Tamala S Bradham, Kelly C Sponsler, Scott C Watkins, Jesse M Ehrenfeld
PROBLEM: More than half of U.S. medical schools have implemented curricula addressing quality improvement (QI); however, the evidence on which pedagogical methods are most effective is limited. APPROACH: As of January 2015, students at Vanderbilt University School of Medicine are required to take a QI course consisting of three 1-month-long (4 hours per week) blocks during their third or fourth year, in which student-identified faculty sponsors are paired with highly trained QI professionals from Vanderbilt University Medical Center...
May 2, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29726085/evaluating-patient-reported-outcome-measures-proms-for-bladder-cancer-a-systematic-review-using-the-cosmin-checklist
#11
REVIEW
Samantha J Mason, James Wf Catto, Amy Downing, Sarah E Bottomley, Adam W Glaser, Penny Wright
Patient Reported Outcome Measures (PROMs) are important tools used to understand patient focused outcomes from care. Various PROMs have been developed for patients with Bladder Cancer (BC), although the disease's heterogeneity makes selection difficult. Accurate measurement of Health Related Quality of Life (HRQL) can only be achieved if the PROM chosen is 'fit for purpose' (i.e. psychometrically sound). Systematic reviews of psychometric properties are useful for selecting the best PROM for a specific purpose...
May 3, 2018: BJU International
https://www.readbyqxmd.com/read/29725960/towards-portable-large-scale-image-processing-with-high-performance-computing
#12
REVIEW
Yuankai Huo, Justin Blaber, Stephen M Damon, Brian D Boyd, Shunxing Bao, Prasanna Parvathaneni, Camilo Bermudez Noguera, Shikha Chaganti, Vishwesh Nath, Jasmine M Greer, Ilwoo Lyu, William R French, Allen T Newton, Baxter P Rogers, Bennett A Landman
High-throughput, large-scale medical image computing demands tight integration of high-performance computing (HPC) infrastructure for data storage, job distribution, and image processing. The Vanderbilt University Institute for Imaging Science (VUIIS) Center for Computational Imaging (CCI) has constructed a large-scale image storage and processing infrastructure that is composed of (1) a large-scale image database using the eXtensible Neuroimaging Archive Toolkit (XNAT), (2) a content-aware job scheduling platform using the Distributed Automation for XNAT pipeline automation tool (DAX), and (3) a wide variety of encapsulated image processing pipelines called "spiders...
May 3, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29718558/a-simple-staging-system-for-osteosarcoma-performs-equivalently-to-the-ajcc-and-msts-systems
#13
Justin M M Cates
Both the American Joint Committee on Cancer (AJCC) and Musculoskeletal Tumor Society (MSTS) staging systems for skeletal sarcomas have major weaknesses. A revised staging system for osteosarcoma (the Vanderbilt system) was developed based on exploratory analyses of the relative prognostic impacts of histologic grade, tumor size, local tumor extension, and specific anatomic sites of metastasis using case records from the National Cancer Database (N = 4,285). AJCC, MSTS, and Vanderbilt staging schemes were then compared using a separate, population-based cancer registry (the Surveillance, Epidemiology, and End Results database; N = 2,246) as a validation dataset...
May 2, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29710220/rate-of-unverifiable-publications-among-ophthalmology-residency-applicants-invited-to-interview
#14
Heather M Tamez, Robert Tauscher, Eric N Brown, Laura Wayman, Louise A Mawn
Importance: Unverifiable publications in applications for ophthalmology residencies could be a serious concern if they represent publication dishonesty. Objective: To determine the rate of unverifiable publications among applicants offered an interview. Design: Retrospective review of 322 ophthalmology residency applications for entering classes 2012 to 2017 at Vanderbilt University School of Medicine, Nashville, Tennessee. Interventions: Full-length publications reported in the applications were searched in PubMed, Google, Google Scholar, and directly on the journal's website...
April 19, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29709069/predicting-suicide-attempts-in-adolescents-with-longitudinal-clinical-data-and-machine-learning
#15
Colin G Walsh, Jessica D Ribeiro, Joseph C Franklin
BACKGROUND: Adolescents have high rates of nonfatal suicide attempts, but clinically practical risk prediction remains a challenge. Screening can be time consuming to implement at scale, if it is done at all. Computational algorithms may predict suicide risk using only routinely collected clinical data. We used a machine learning approach validated on longitudinal clinical data in adults to address this challenge in adolescents. METHODS: This is a retrospective, longitudinal cohort study...
April 30, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29708863/addressing-the-growing-opioid-and-heroin-abuse-epidemic-a-call-for-medical-school-curricula
#16
Madison C Ratycz, Thomas J Papadimos, Allison A Vanderbilt
Substance abuse is a growing public health concern in the USA (US), especially now that the US faces a national drug overdose epidemic. Over the past decade, the number of drug overdose deaths has rapidly grown, largely driven by increases in prescription opioid-related overdoses. In recent years, increased heroin and illicitly manufactured fentanyl overdoses have substantially contributed to the rise of overdose deaths. Given the role of physicians in interacting with patients who are at risk for or currently abusing opioids and heroin, it is essential that physicians are aware of this issue and know how to respond...
December 2018: Medical Education Online
https://www.readbyqxmd.com/read/29708221/relationships-between-full-day-arm-movement-characteristics-and-developmental-status-in-infants-with-typical-development-as-they-learn-to-reach-an-observational-study
#17
Joanne Shida-Tokeshi, Christianne J Lane, Ivan A Trujillo-Priego, Weiyang Deng, Douglas L Vanderbilt, Gerald E Loeb, Beth A Smith
Background: Advances in wearable sensor technology now allow us to quantify the number, type and kinematic characteristics of bouts of infant arm movement made across a full day in the natural environment. Our aim here was to determine whether the amount and kinematic characteristics of arm movements made across the day in the natural environment were related to developmental status in infants with typical development as they learned to reach for objects using their arms. Methods: We used wearable sensors to measure arm movement across days and months as infants developed arm reaching skills...
April 5, 2018: Gates open research
https://www.readbyqxmd.com/read/29702372/cerebrospinal-fluid-%C3%AE-amyloid-42-and-neurofilament-light-relate-to-white-matter-hyperintensities
#18
Katie E Osborn, Dandan Liu, Lauren R Samuels, Elizabeth E Moore, Francis E Cambronero, Lealani Mae Y Acosta, Susan P Bell, Michelle A Babicz, Elizabeth A Gordon, Kimberly R Pechman, L Taylor Davis, Katherine A Gifford, Timothy J Hohman, Kaj Blennow, Henrik Zetterberg, Angela L Jefferson
White matter hyperintensities (WMHs) are associated with poorer brain health, but their pathophysiological substrates remain elusive. To better understand the mechanistic underpinnings of WMHs among older adults, this study examined in vivo cerebrospinal fluid biomarkers of β-amyloid42 deposition (Aβ42 ), hyperphosphorylated tau pathology, neurodegeneration (total tau), and axonal injury (neurofilament light [NFL]) in relation to log-transformed WMHs volume. Participants free of clinical stroke and dementia were drawn from the Vanderbilt Memory & Aging Project (n = 148, 72 ± 6 years)...
April 3, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29679162/circulating-troponin-i-level-in-patients-with-acute-ischemic-stroke
#19
REVIEW
Jacob VanHouten, Gregory Fricker, Bridget Collins, Ritwik Bhatia, Christopher Ellis, Matthew Schrag
PURPOSE OF REVIEW: Cardiac troponin levels in the blood are an important biomarker of acute coronary events, but may also be elevated in the context of acute ischemic stroke without an obvious concurrent myocardial insult. The objective of this study and systematic review is to determine how high the circulating troponin I level can rise due to ischemic stroke. RECENT FINDINGS: Anonymized medical records from Vanderbilt University Medical Center were reviewed identifying 151,972 unique acute ischemic stroke events, of which 1226 met criteria for inclusion in this study...
April 20, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29678121/the-relationship-between-adverse-neighborhood-socioeconomic-context-and-hiv-continuum-of-care-outcomes-in-a-diverse-hiv-clinic-cohort-in-the-southern-united-states
#20
Peter F Rebeiro, Chanelle J Howe, William B Rogers, Sally S Bebawy, Megan Turner, Asghar Kheshti, Catherine C McGowan, Stephen P Raffanti, Timothy R Sterling
Retention in care and viral suppression are critical to delaying HIV progression and reducing transmission. Neighborhood socioeconomic context (NSEC) may affect HIV care receipt. We therefore assessed NSEC's impact on retention and viral suppression in a diverse HIV clinical cohort. HIV-positive adults with ≥1 visit at the Vanderbilt Comprehensive Care Clinic and 5-digit ZIP code tabulation area (ZCTA) information between 2008 and 2012 contributed. NSEC z-score indices used neighborhood-level socioeconomic indicators for poverty, education, labor-force participation, proportion of males, median age, and proportion of residents of black race by ZCTA...
April 20, 2018: AIDS Care
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