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https://www.readbyqxmd.com/read/29339723/fasoracetam-in-adolescents-with-adhd-and-glutamatergic-gene-network-variants-disrupting-mglur-neurotransmitter-signaling
#1
Josephine Elia, Grace Ungal, Charlly Kao, Alexander Ambrosini, Nilsa De Jesus-Rosario, Lene Larsen, Rosetta Chiavacci, Tiancheng Wang, Christine Kurian, Kanani Titchen, Brian Sykes, Sharon Hwang, Bhumi Kumar, Jacqueline Potts, Joshua Davis, Jeffrey Malatack, Emma Slattery, Ganesh Moorthy, Athena Zuppa, Andrew Weller, Enda Byrne, Yun R Li, Walter K Kraft, Hakon Hakonarson
The glutamatergic neurotransmitter system may play an important role in attention-deficit hyperactivity disorder (ADHD). This 5-week, open-label, single-blind, placebo-controlled study reports the safety, pharmacokinetics and responsiveness of the metabotropic glutamate receptor (mGluR) activator fasoracetam (NFC-1), in 30 adolescents, age 12-17 years with ADHD, harboring mutations in mGluR network genes. Mutation status was double-blinded. A single-dose pharmacokinetic profiling from 50-800 mg was followed by a single-blind placebo at week 1 and subsequent symptom-driven dose advancement up to 400 mg BID for 4 weeks...
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29332109/prevalence-of-attention-deficit-hyperactivity-disorder-and-comorbid-psychiatric-and-behavioral-problems-among-primary-school-students-in-western-saudi-arabia
#2
Faten N AlZaben, Mohammad G Sehlo, Waleed A Alghamdi, Haythum O Tayeb, Doaa A Khalifa, Abdulrahman T Mira, Abdulaziz M Alshuaibi, Mosab A Alguthmi, Ahmad A Derham, Harold G Koenig
To determine the prevalence of attention deficit hyperactivity disorder (ADHD), subtypes of ADHD, and psychiatric, academic, and behavioral comorbidity in public primary school students in Jeddah, Saudi Arabia.  Methods: This is a cross-sectional study. A simple random sample of 6 primary government schools in Jeddah, Saudi Arabia, was identified (3 male, 3 female), and a random sample of classes in each of grades 1-6 were selected. Between July and November 2016, teachers in these classes were asked to complete the Vanderbilt ADHD scale on all students in their classes...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29330700/relation-between-internalizing-behaviors-externalizing-behaviors-and-peer-victimization-among-children-with-and-without-adhd
#3
Nicholas D Fogleman, Kirsten D Leaberry, Paul J Rosen, Danielle M Walerius, Kelly E Slaughter
The current study explored the concurrent and longitudinal association between internalizing behaviors, externalizing behaviors, and peer victimization among children with and without ADHD. Eighty children (42 ADHD, 38 non-ADHD) ages 8-12 participated in the present study conducted over a 6-month period. During the baseline session, parents completed a structured diagnostic interview and the Vanderbilt ADHD Parent Rating Scale to determine whether their child met criteria for ADHD, and the Child Behavior Checklist (CBCL) to assess their child's internalizing and externalizing behaviors; children completed the Perception of Peer Support Scale (PPSS) to assess experiences of peer victimization...
January 12, 2018: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/29329316/electroencephalography-power-and-coherence-changes-with-age-and-motor-skill-development-across-the-first-half-year-of-life
#4
Ran Xiao, Joanne Shida-Tokeshi, Douglas L Vanderbilt, Beth A Smith
Existing research in infants has correlated electroencephalography (EEG) measures of power and coherence to cognitive development and to locomotor experience, but only in infants older than 5 months of age. Our goal was to explore the relationship between EEG measures of power and coherence and motor skill development in younger infants who are developing reaching skill. Twenty-one infants with typical development between 38 and 203 days of age participated. Longitudinal EEG recording sessions were recorded in monthly increments, with 3-5 sessions acquired for 19 participants and 1 session for 2 participants, resulting in 71 sessions in total...
2018: PloS One
https://www.readbyqxmd.com/read/29325441/five-year-experience-of-an-inpatient-palliative-care-unit-at-an-academic-referral-center
#5
Myrick C Shinall, Sara F Martin, Jill Nelson, Richard S Miller, Matthew W Semler, Eli E Zimmerman, Christy C Noblit, E Wesley Ely, Mohana Karlekar
BACKGROUND: Palliative care units (PCUs) staffed by specialty-trained physicians and nurses have been established in a number of medical centers. The purpose of this study is to review the 5-year experience of a PCU at a large, urban academic referral center. METHODS: We retrospectively reviewed a prospectively collected database of all admissions to the PCU at Vanderbilt University Medical Center in the first 5 years of its existence, from 2012 through 2017. RESULTS: Over these 5 years, there were 3321 admissions to the PCU...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29314091/the-relationship-between-preoperative-fetal-head-circumference-and-2-year-cognitive-performance-after-laser-surgery-for-twin-twin-transfusion-syndrome
#6
Andrew H Chon, Mary Rose Mamey, Sheree M Schrager, Douglas L Vanderbilt, Ramen H Chmait
OBJECTIVE: To determine the relationship between preoperative fetal head circumference (HC) and cognitive performance among children treated with laser surgery for twin-twin transfusion syndrome (TTTS). METHODS: Donor and recipient twin HCs were measured preoperatively (16 - 26 weeks' gestation) and at 2 years corrected age. Multilevel multivariate regression models were used to test pregnancy and child-level risk factors for lower Battelle Developmental Inventory 2nd Edition (BDI-2) scores...
January 4, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29304051/psychometric-validation-study-of-the-korean-version-of-the-functional-assessment-of-cancer-therapy-vanderbilt-cystectomy-index
#7
Myong Kim, Seung-June Oh, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
PURPOSES: To evaluate the reliability and validity of a Korean version of the Functional Assessment of Cancer Therapy (FACT)-Vanderbilt Cystectomy Index (VCI) in Korean patients who underwent radical cystectomy (RC) and urinary diversion (UD). MATERIALS AND METHODS: We prospectively recruited 108 RC and UD patients who did not have evidence of recurrence from 1994 December to 2015 March. All participants were instructed to complete the Korean FACT-VCI and Short-Form 36-Item Health Survey (SF-36; 1st measurement) and to repeat the Korean FACT-VCI survey one month later (2nd measurement)...
2018: PloS One
https://www.readbyqxmd.com/read/29301521/training-the-next-generation-of-physician-researchers-vanderbilt-medical-scholars-program
#8
Abigail M Brown, Teresa M Chipps, Tebeb Gebretsadik, Lorraine B Ware, Jessica Y Islam, Luke R Finck, Joey Barnett, Tina V Hartert
BACKGROUND: As highlighted in recent reports published by the Physician-Scientist Workforce Working Group at the National Institutes of Health, the percentage of physicians conducting research has declined over the past decade. Various programs have been put in place to support and develop current medical student interest in research to alleviate this shortage, including The Vanderbilt University School of Medicine Medical Scholars Program (MSP). This report outlines the long-term program goals and short-term outcomes on career development of MSP alumni, to shed light on the effectiveness of research training programs during undergraduate medical training to inform similar programs in the United States...
January 4, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29282827/links-between-sleep-and-daytime-behaviour-problems-in-children-with-down-syndrome
#9
A J Esbensen, E K Hoffman, D W Beebe, K C Byars, J Epstein
BACKGROUND: In the general population, sleep problems have an impact on daytime performance. Despite sleep problems being common among children with Down syndrome, the impact of sleep problems on daytime behaviours in school-age children with Down syndrome is an understudied topic. Our study examined the relationship between parent-reported and actigraphy-measured sleep duration and sleep quality with parent and teacher reports of daytime behaviour problems among school-age children with Down syndrome...
December 28, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29274640/effectiveness-of-the-malnutrition-quality-improvement-initiative-on-practitioner-malnutrition-knowledge-and-screening-diagnosis-and-timeliness-of-malnutrition-related-care-provided-to-older-adults-admitted-to-a-tertiary-care-facility-a-pilot-study
#10
Heidi J Silver, Kelsey Jones Pratt, Michelle Bruno, Joe Lynch, Kristi Mitchell, Sharon M McCauley
BACKGROUND: Malnutrition is present in 30% to 50% of hospitalized patients aged 60 years or older. As few as 3.2% of patients identified as high risk have a malnutrition diagnosis documented by medical providers. The Malnutrition Quality Improvement Initiative (MQii) aims to reduce the burden of hospital malnutrition by improving the process and delivery of care. OBJECTIVE: To evaluate implementing the MQii toolkit of best practice resources for screening, diagnosis, documentation, and timeliness of malnutrition care...
January 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29243976/stereotactic-eeg-via-multiple-single-path-omnidirectional-trajectories-within-a-single-platform-institutional-experience-with-a-novel-technique
#11
Michael C Dewan, Robert Shults, Andrew T Hale, Vishad Sukul, Dario J Englot, Peter Konrad, Hong Yu, Joseph S Neimat, William Rodriguez, Benoit M Dawant, Srivatsan Pallavaram, Robert P Naftel
OBJECTIVE Stereotactic electroencephalography (SEEG) is being used with increasing frequency to interrogate subcortical, cortical, and multifocal epileptic foci. The authors describe a novel technique for SEEG in patients with suspected epileptic foci refractory to medical management. METHODS In the authors' technique, standard epilepsy evaluation and neuroimaging are used to create a hypothesis-driven SEEG plan, which informs the 3D printing of a novel single-path, multiple-trajectory, omnidirectional platform...
December 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29202956/admixture-mapping-of-uterine-fibroid-size-and-number-in-african-american-women
#12
MULTICENTER STUDY
Michael J Bray, Todd L Edwards, Melissa F Wellons, Sarah H Jones, Katherine E Hartmann, Digna R Velez Edwards
OBJECTIVE: To evaluate the relationship between genetic ancestry and uterine fibroid characteristics. DESIGN: Cross-sectional study. SETTING: Not applicable. PATIENT(S): A total of 609 African American participants with image- or surgery-confirmed fibroids in a biorepository at Vanderbilt University electronic health record biorepository and the Coronary Artery Risk Development in Young Adults studies were included. INTERVENTION(S): None...
December 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29193180/considerations-for-analysis-of-time-to-event-outcomes-measured-with-error-bias-and-correction-with-simex
#13
Eric J Oh, Bryan E Shepherd, Thomas Lumley, Pamela A Shaw
For time-to-event outcomes, a rich literature exists on the bias introduced by covariate measurement error in regression models, such as the Cox model, and methods of analysis to address this bias. By comparison, less attention has been given to understanding the impact or addressing errors in the failure time outcome. For many diseases, the timing of an event of interest (such as progression-free survival or time to AIDS progression) can be difficult to assess or reliant on self-report and therefore prone to measurement error...
November 29, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29192303/association-between-ophthalmologist-age-and-unsolicited-patient-complaints
#14
Cherie A Fathy, James W Pichert, Henry Domenico, Sahar Kohanim, Paul Sternberg, William O Cooper
Importance: Understanding the distribution of patient complaints by physician age may provide insight into common patient concerns characteristic of early, middle, and late stages of careers in ophthalmology. Most previous studies of patient dissatisfaction have not addressed the association with physician age or controlled for other characteristics (eg, practice setting, subspecialty) that may contribute to the likelihood of patient complaints, unsafe care, and lawsuits. Objective: To assess the association between ophthalmologist age and the likelihood of generating unsolicited patient complaints (UPCs) among a cohort of ophthalmologists...
November 30, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29168320/pulmonary-hypertension-in-the-premature-infant-population-analysis-of-echocardiographic-findings-and-biomarkers
#15
Michael G O'Connor, Divya Suthar, Kimberly Vera, James C Slaughter, Natalie L Maitre, Steven Steele, Amy Beller, Candice D Fike, Judy L Aschner, Paul E Moore, Eric D Austin
OBJECTIVE: Extremely low gestational age neonates (ELGANs) are at risk for pulmonary hypertension (PH). We hypothesized that PH, defined by echocardiogram at 36 weeks gestational age (GA), would associate with respiratory morbidity, increased oxidant stress, and reduced nitric oxide production. STUDY DESIGN: ELGANs in the Vanderbilt fraction of the Prematurity and Respiratory Outcomes Program (PROP) who had echocardiograms at 36 ± 1 weeks GA were studied. Echocardiogram features of PH were compared with clinical characteristics as well as markers of oxidant stress and components of the nitric oxide pathway...
November 23, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29164347/an-epic-switch-preparing-for-an-electronic-health-record-transition-at-vanderbilt-university-medical-center
#16
EDITORIAL
Kevin B Johnson, Jesse M Ehrenfeld
No abstract text is available yet for this article.
November 21, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29130437/remote-hearing-aid-support-the-next-frontier
#17
Gina P Angley, Jean Anne Schnittker, Anne Marie Tharpe
BACKGROUND: In an effort to reduce health-care disparities, there has been a recent surge of interest in the remote provision of care. Audiologists have begun to provide screening, diagnostic, and rehabilitative services via telehealth technologies. PURPOSE: To evaluate the feasibility and perceived benefits of providing remote hearing aid follow-up appointments in a controlled clinical environment and in participants' homes. RESEARCH DESIGN: A descriptive quasi-experimental study was completed...
November 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29117962/lower-cardiac-index-levels-relate-to-lower-cerebral-blood-flow-in-older-adults
#18
Angela L Jefferson, Dandan Liu, Deepak K Gupta, Kimberly R Pechman, Jennifer M Watchmaker, Elizabeth A Gordon, Swati Rane, Susan P Bell, Lisa A Mendes, L Taylor Davis, Katherine A Gifford, Timothy J Hohman, Thomas J Wang, Manus J Donahue
OBJECTIVE: To assess cross-sectionally whether lower cardiac index relates to lower resting cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) among older adults. METHODS: Vanderbilt Memory & Aging Project participants free of stroke, dementia, and heart failure were studied (n = 314, age 73 ± 7 years, 59% male, 39% with mild cognitive impairment). Cardiac index (liters per minute per meter squared) was quantified from echocardiography. Resting CBF (milliliters per 100 grams per minute) and hypercapnia-induced CVR were quantified from pseudo-continuous arterial spin-labeling MRI...
December 5, 2017: Neurology
https://www.readbyqxmd.com/read/29114479/sample-entropy-identifies-differences-in-spontaneous-leg-movement-behavior-between-infants-with-typical-development-and-infants-at-risk-of-developmental-delay
#19
Beth A Smith, Douglas L Vanderbilt, Bryon Applequist, Anastasia Kyvelidou
We are interested in using wearable sensor data to analyze detailed characteristics of movement, such as repeatability and variability of movement patterns, over days and months to accurately capture real-world infant behavior. The purpose of this study was to explore Sample Entropy (SampEn) from wearable sensor data as a measure of variability of spontaneous infant leg movement and as a potential marker of the development of neuromotor control. We hypothesized that infants at risk (AR) of developmental delay would present significantly lower SampEn values than infants with typical development (TD)...
September 2017: Technologies
https://www.readbyqxmd.com/read/29071338/prognostic-effect-and-longitudinal-hemodynamic-assessment-of-borderline-pulmonary-hypertension
#20
Tufik R Assad, Bradley A Maron, Ivan M Robbins, Meng Xu, Shi Huang, Frank E Harrell, Eric H Farber-Eger, Quinn S Wells, Gaurav Choudhary, Anna R Hemnes, Evan L Brittain
Importance: Pulmonary hypertension (PH) is diagnosed by a mean pulmonary arterial pressure (mPAP) value of at least 25 mm Hg during right heart catheterization (RHC). While several studies have demonstrated increased mortality in patients with mPAP less than that threshold, little is known about the natural history of borderline PH. Objective: To test the hypothesis that patients with borderline PH have decreased survival compared with patients with lower mPAP and frequently develop overt PH and to identify clinical correlates of borderline PH...
October 25, 2017: JAMA Cardiology
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