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https://www.readbyqxmd.com/read/29168320/pulmonary-hypertension-in-the-premature-infant-population-analysis-of-echocardiographic-findings-and-biomarkers
#1
Michael G O'Connor, Divya Suthar, Kimberly Vera, James C Slaughter, Natalie L Maitre, Steven Steele, Amy Beller, Candice D Fike, Judy L Aschner, Paul E Moore, Eric D Austin
OBJECTIVE: Extremely low gestational age neonates (ELGANs) are at risk for pulmonary hypertension (PH). We hypothesized that PH, defined by echocardiogram at 36 weeks gestational age (GA), would associate with respiratory morbidity, increased oxidant stress, and reduced nitric oxide production. STUDY DESIGN: ELGANs in the Vanderbilt fraction of the Prematurity and Respiratory Outcomes Program (PROP) who had echocardiograms at 36 ± 1 weeks GA were studied. Echocardiogram features of PH were compared with clinical characteristics as well as markers of oxidant stress and components of the nitric oxide pathway...
November 23, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29164347/an-epic-switch-preparing-for-an-electronic-health-record-transition-at-vanderbilt-university-medical-center
#2
EDITORIAL
Kevin B Johnson, Jesse M Ehrenfeld
No abstract text is available yet for this article.
November 21, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29130437/remote-hearing-aid-support-the-next-frontier
#3
Gina P Angley, Jean Anne Schnittker, Anne Marie Tharpe
BACKGROUND: In an effort to reduce health-care disparities, there has been a recent surge of interest in the remote provision of care. Audiologists have begun to provide screening, diagnostic, and rehabilitative services via telehealth technologies. PURPOSE: To evaluate the feasibility and perceived benefits of providing remote hearing aid follow-up appointments in a controlled clinical environment and in participants' homes. RESEARCH DESIGN: A descriptive quasi-experimental study was completed...
November 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29117962/lower-cardiac-index-levels-relate-to-lower-cerebral-blood-flow-in-older-adults
#4
Angela L Jefferson, Dandan Liu, Deepak K Gupta, Kimberly R Pechman, Jennifer M Watchmaker, Elizabeth A Gordon, Swati Rane, Susan P Bell, Lisa A Mendes, L Taylor Davis, Katherine A Gifford, Timothy J Hohman, Thomas J Wang, Manus J Donahue
OBJECTIVE: To assess cross-sectionally whether lower cardiac index relates to lower resting cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) among older adults. METHODS: Vanderbilt Memory & Aging Project participants free of stroke, dementia, and heart failure were studied (n = 314, age 73 ± 7 years, 59% male, 39% with mild cognitive impairment). Cardiac index (liters per minute per meter squared) was quantified from echocardiography. Resting CBF (milliliters per 100 grams per minute) and hypercapnia-induced CVR were quantified from pseudo-continuous arterial spin-labeling MRI...
November 8, 2017: Neurology
https://www.readbyqxmd.com/read/29114479/sample-entropy-identifies-differences-in-spontaneous-leg-movement-behavior-between-infants-with-typical-development-and-infants-at-risk-of-developmental-delay
#5
Beth A Smith, Douglas L Vanderbilt, Bryon Applequist, Anastasia Kyvelidou
We are interested in using wearable sensor data to analyze detailed characteristics of movement, such as repeatability and variability of movement patterns, over days and months to accurately capture real-world infant behavior. The purpose of this study was to explore Sample Entropy (SampEn) from wearable sensor data as a measure of variability of spontaneous infant leg movement and as a potential marker of the development of neuromotor control. We hypothesized that infants at risk (AR) of developmental delay would present significantly lower SampEn values than infants with typical development (TD)...
September 2017: Technologies
https://www.readbyqxmd.com/read/29071338/prognostic-effect-and-longitudinal-hemodynamic-assessment-of-borderline-pulmonary-hypertension
#6
Tufik R Assad, Bradley A Maron, Ivan M Robbins, Meng Xu, Shi Huang, Frank E Harrell, Eric H Farber-Eger, Quinn S Wells, Gaurav Choudhary, Anna R Hemnes, Evan L Brittain
Importance: Pulmonary hypertension (PH) is diagnosed by a mean pulmonary arterial pressure (mPAP) value of at least 25 mm Hg during right heart catheterization (RHC). While several studies have demonstrated increased mortality in patients with mPAP less than that threshold, little is known about the natural history of borderline PH. Objective: To test the hypothesis that patients with borderline PH have decreased survival compared with patients with lower mPAP and frequently develop overt PH and to identify clinical correlates of borderline PH...
October 25, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29064272/recommended-reading-from-vanderbilt-university-pediatric-pulmonary-fellows
#7
Mark Wurth, Christina M Papantonakis, Rebekah J Nevel, Caroline S Thomas, Andrew G Sokolow, Paul E Moore, Christian Rosas-Salazar
No abstract text is available yet for this article.
October 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29059268/evaluation-of-a-reflex-testing-algorithm-for-suspected-heparin-induced-thrombocytopenia
#8
Chad M Vanderbilt, Craig McFarland, Stuart E Lind
Objectives: We implemented a policy of reflex serotonin-release assay (SRA) testing for all patients with a positive heparin-induced thrombocytopenia (HIT) immunoassay. Methods: We identified all patients who had SRA testing sent as a consequence of a positive HIT immunoassay test. We reviewed charts of patients to calculate the 4Ts clinical score, determined the effect of testing on clinical management, and documented the change in utilization of direct thrombin inhibitors (DTIs)...
November 2, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29029564/psychometric-validation-of-the-revised-child-anxiety-and-depression-scales-parent-version-rcads-p-in-children-evaluated-for-adhd
#9
Stephen P Becker, Dana N Schindler, Aaron M Luebbe, Leanne Tamm, Jeffery N Epstein
Children with attention-deficit/hyperactivity disorder (ADHD) frequently experience comorbid internalizing symptoms. The Revised Child Anxiety and Depression Scales-Parent Version (RCADS-P) is a frequently used measure of anxiety and depression in children, though its psychometric properties remain unexamined in children referred for ADHD specifically. The present study evaluated the RCADS-P in 372 children (age 7-12 years; 68% male) referred for evaluation at an ADHD specialty clinic (89% met criteria for ADHD)...
October 1, 2017: Assessment
https://www.readbyqxmd.com/read/29028896/pydream-high-dimensional-parameter-inference-for-biological-models-in-python
#10
Erin M Shockley, Jasper A Vrugt, Carlos F Lopez
Summary: Biological models contain many parameters whose values are difficult to measure directly via experimentation and therefore require calibration against experimental data. Markov chain Monte Carlo (MCMC) methods are suitable to estimate multivariate posterior model parameter distributions, but these methods may exhibit slow or premature convergence in high-dimensional search spaces. Here, we present PyDREAM, a Python implementation of the (Multiple-Try) Differential Evolution Adaptive Metropolis (DREAM(ZS)) algorithm developed by Vrugt and ter Braak (2008) and Laloy and Vrugt (2012)...
October 4, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29016793/mining-100-million-notes-to-find-homelessness-and-adverse-childhood-experiences-2-case-studies-of-rare-and-severe-social-determinants-of-health-in-electronic-health-records
#11
Cosmin A Bejan, John Angiolillo, Douglas Conway, Robertson Nash, Jana K Shirey-Rice, Loren Lipworth, Robert M Cronin, Jill Pulley, Sunil Kripalani, Shari Barkin, Kevin B Johnson, Joshua C Denny
Objective: Understanding how to identify the social determinants of health from electronic health records (EHRs) could provide important insights to understand health or disease outcomes. We developed a methodology to capture 2 rare and severe social determinants of health, homelessness and adverse childhood experiences (ACEs), from a large EHR repository. Materials and Methods: We first constructed lexicons to capture homelessness and ACE phenotypic profiles. We employed word2vec and lexical associations to mine homelessness-related words...
July 8, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29016789/a-technology-based-patient-and-family-engagement-consult-service-for-the-pediatric-hospital-setting
#12
Gretchen P Jackson, Jamie R Robinson, Ebone Ingram, Mary Masterman, Catherine Ivory, Diane Holloway, Shilo Anders, Robert M Cronin
Objective: The Vanderbilt Children's Hospital launched an innovative Technology-Based Patient and Family Engagement Consult Service in 2014. This paper describes our initial experience with this service, characterizes health-related needs of families of hospitalized children, and details the technologies recommended to promote engagement and meet needs. Materials and Methods: We retrospectively reviewed consult service documentation for patient characteristics, health-related needs, and consultation team recommendations...
July 22, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28989953/individual-differences-in-perceptual-abilities-in-medical-imaging-the-vanderbilt-chest-radiograph-test
#13
Mackenzie A Sunday, Edwin Donnelly, Isabel Gauthier
Radiologists make many important decisions when detecting nodules on chest radiographs. While training can result in high levels of performance of this task, there could be individual differences in relevant perceptual abilities that are present pre-training. A pre-requisite to address this question is a valid and reliable measure of such abilities. The present work introduces a new measure, the Vanderbilt Chest Radiograph Test (VCRT), which aims to quantify individual differences in perceptual abilities for radiograph-related decision-making in novices...
2017: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/28989001/hpv-related-nasopharyngeal-and-cervical-cancer-in-a-married-couple-in-north-america
#14
Daniel B Vanderbilt, Quoc-Anh Ho, Uma Goyal, Robert C Bell, Robert R Klein, Sun K Yi
No abstract text is available yet for this article.
September 8, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28988384/language-barriers-impact-access-to-services-for-children-with-autism-spectrum-disorders
#15
Helaine G St Amant, Sheree M Schrager, Carolina Peña-Ricardo, Marian E Williams, Douglas L Vanderbilt
Racial and ethnic disparities in accessing health care have been described in children with autism spectrum disorder (ASD). In a retrospective chart review of 152 children with ASD, children of parents whose primary language was English were significantly more likely to have both social skills and communication goals within their individualized education plan (IEP) compared to children of parents whose primary language was not English. Additionally, children of primary English speakers received significantly more hours of direct services from their state disability program...
October 7, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28986425/utilization-of-a-smartphone-platform-for-electronic-informed-consent-in-acute-stroke-trials
#16
RANDOMIZED CONTROLLED TRIAL
Diogo C Haussen, Shannon Doppelheuer, Kiva Schindler, Jonathan A Grossberg, Mehdi Bouslama, Meagan Schultz, Hilarie Perez, Alex Hall, Michael Frankel, Raul G Nogueira
BACKGROUND AND PURPOSE: The informed consent process is a major limitation for enrollment in acute stroke clinical investigations. We aim to describe the novel application of smartphone electronic informed consenting (e-Consent) in trials of cerebral thrombectomy. METHODS: The e-Consent tool consists of a secure/Health Insurance Portability and Accountability Act compliant smartphone platform based on REDCap (Research Electronic Data Capture; Vanderbilt University, TN) that uses a survey project located on a static webpage...
November 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28979835/a-comparison-of-best-practices-for-doctoral-training-in-europe-and-north-america
#17
Joey V Barnett, Robert A Harris, Michael J Mulvany
The PhD degree was established in Berlin 200 years ago and has since spread across the whole world. While there is general agreement that the degree is awarded in recognition of successfully completed research training, there have been significant differences in the way doctoral training programs have developed in particular countries. There is, however, a clear global tendency to follow the programs currently used either in the United States or in Europe. To determine more clearly how US and European PhD programs are both similar and different, we have used a validated questionnaire to analyze biomedical PhD programs in four representative institutions at Vanderbilt University, University of Manitoba, Karolinska Institutet, and Graz Medical University...
October 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28973705/identification-and-management-of-tp53-gene-carriers-detected-through-multigene-panel-testing
#18
Tuya Pal, Jennifer Brzosowicz, Ailyn Valladares, Georgia L Wiesner, Christine Laronga
OBJECTIVES: The increasing use of multigene panel tests may reveal an unexpected pathogenic variant in the tumor protein p53 (TP53) gene among individuals who do not meet clinical criteria for Li-Fraumeni syndrome (LFS). Among a registry-based sample of individuals with a pathogenic (P) or likely pathogenic (LP) variant in TP53, we sought to characterize the original clinical context in which genetic testing was performed, the personal and family history and whether they met clinical LFS criteria, and the follow-up care following diagnosis among those in whom this information was available...
October 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28916403/a-case-of-severe-acquired-hypertriglyceridemia-in-a-7-year-old-girl
#19
Jessica S Lilley, MacRae F Linton, Jennifer C Kelley, T Brent Graham, Sergio Fazio, Hagai Tavori
We report a case of severe type I hyperlipoproteinemia caused by autoimmunity against lipoprotein lipase (LPL) in the context of presymptomatic Sjögren's syndrome. A 7-year-old mixed race (Caucasian/African American) girl was admitted to the intensive care unit at Vanderbilt Children's Hospital with acute pancreatitis and shock. She was previously healthy aside from asthma and history of Hashimoto's thyroiditis. Admission triglycerides (TGs) were 2191 mg/dL but returned to normal during the hospital stay and in the absence of food intake...
August 12, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28892449/emergency-preparedness-in-the-workplace-the-flulapalooza-model-for-mass-vaccination
#20
Melanie D Swift, Muktar H Aliyu, Daniel W Byrne, Keqin Qian, Paula McGown, Patricia O Kinman, Katherine Louise Hanson, Demoyne Culpepper, Tamara J Cooley, Mary I Yarbrough
OBJECTIVES: To explore whether an emergency preparedness structure is a feasible, efficient, and sustainable way for health care organizations to manage mass vaccination events. METHODS: We used the Hospital Incident Command System to conduct a 1-day annual mass influenza vaccination event at Vanderbilt University Medical Center over 5 successive years (2011-2015). Using continuous quality improvement principles, we assessed whether changes in layout, supply management, staffing, and documentation systems improved efficiency...
September 2017: American Journal of Public Health
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