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https://www.readbyqxmd.com/read/30637710/the-role-of-immunotherapy-in-small-cell-lung-cancer
#1
REVIEW
A Calles, G Aguado, C Sandoval, R Álvarez
Despite decades of research, prognosis for SCLC patients remains poor, and treatment options limited. SCLC is an immunogenic tumor with high somatic mutation rates due to tobacco exposure resulting in potential neo-antigens, the presence of suppressed immune responses, and occurrence of paraneoplastic disorders. The use of T cell immune-checkpoint inhibitors (anti-PD1: nivolumab, pembrolizumab; anti-PD-L1: atezolizumab, durvalumab; anti-CTLA-4: ipilimumab, tremelimumab) have shown promising antitumor activity with the potential to prolong survival in SCLC patients...
January 12, 2019: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/30627102/lambert-eaton-myasthenic-syndrome-caused-by-nivolumab-in-a-patient-with-squamous-cell-lung-cancer
#2
Yuki Nakatani, Natsuki Tanaka, Tomomi Enami, Seigo Minami, Tomoko Okazaki, Kiyoshi Komuta
Lambert-Eaton myasthenic syndrome (LEMS) is a representative paraneoplastic neurological syndrome. Recently, nivolumab, an anti-programmed cell death 1 inhibitor, has been approved for advanced non-small-cell lung cancer. Careful attention should be paid to immune-related adverse events (irAEs), including neurotoxicity. We herein report a 73-year-old woman with LEMS that occurred during nivolumab treatment for pulmonary squamous cell carcinoma. After the 20th week of nivolumab, she experienced various neurological symptoms such as ptosis, lower limb weakness, and photophobia...
September 2018: Case Reports in Neurology
https://www.readbyqxmd.com/read/30626830/successful-treatment-of-ros1-rearranged-lung-cancer-complicated-by-hypertrophic-pulmonary-osteoarthropathy-with-crizotinib-therapy-a-case-report
#3
Naoko Katsurada, Motoko Tachihara, Naoe Jimbo, Kiyoko Koyama, Kyosuke Nakata, Tatsuya Nagano, Masatsugu Yamamoto, Hiroshi Kamiryo, Kazuyuki Kobayashi, Yoshihiro Nishimura
Hypertrophic pulmonary osteoarthropathy (HPO) is a paraneoplastic syndrome characterized by digital clubbing, arthritis, and periostitis. Tumor removal usually leads to the resolution of these symptoms. We herein report the efficacy of crizotinib treatment for treating the symptoms of HPO associated with c-ros oncogene 1 receptor tyrosine kinase (ROS1)-rearranged lung cancer. A 71-year-old woman presented with a pulmonary tumor and arthritis. She was diagnosed with a ROS1-rearranged lung adenocarcinoma (stage IIIB [cT4N2M0]) with HPO...
January 10, 2019: Internal Medicine
https://www.readbyqxmd.com/read/30622890/paraneoplastic-limbic-encephalitis-revealing-a-small-cell-carcinoma-of-the-lung
#4
Marwa Kacem, Nidhal Belloumi, Imene Bachouche, Mariem Mersni, Fatma Chermiti Ben Abdallah, Soraya Fenniche
Introduction: Paraneoplastic limbic encephalitis is a rare disease, usually associated with small cell lung cancer. Case report: We report in this publication the cases with different age brackets, who presented with various neurological symptoms such as repetitive seizures or anterograde amnesia. Cerebral CT-scan, cerebral MRI and anti onco-neural paraneoplastic antibodies were suggesting the diagnosis of paraneoplastic limbic encephalitis. Etiological exploration lead to the diagnosis of locally advanced small cell carcinoma of the lung...
2019: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/30620044/a-systematic-review-of-gamma-aminobutyric-acid-receptor-type-b-autoimmunity
#5
Jake H McKay, Elliot L Dimberg, Alfonso S Lopez Chiriboga
OBJECTIVE: To review the available research to describe the clinical characteristics and neoplastic associations of patients with gamma-aminobutyric acid receptor type B (GABAB-R) autoantibodies. METHODS: Literature was reviewed on PubMed, Mendeley literature search, and the American Academy of Neurology database for articles published from June 2008 to October of 2018 using a variety of key words. These key words include: "gamma-aminobutyric acid seizures," "gamma-aminobutyric acid limbic encephalitis", "GABA(B) receptor antibodies," "autoimmune encephalitis," "autoimmune epilepsy," "GABA(B) encephalitis, " and "GABA paraneoplastic...
January 8, 2019: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/30603606/galactorrhea-mastodynia-and-gynecomastia-as-the-first-manifestation-of-lung-adenocarcinoma-a-case-report
#6
A Lazopoulos, D Krimiotis, N C Schizas, T Rallis, A S Gogakos, F Chatzinikolaou, T Tsiouda, P Zarogoulidis, P Sarafis, P Kamparoudi, D Paliouras, N Barbetakis
Gynecomastia with mastodynia and galactorrhea as a paraneoplastic syndrome due to lung cancer with complete response after surgical excision is rare. A 62-year-old Caucasian male presented with mastodynia, galactorrhea and right breast enlargement. Chest x-ray revealed a left upper lobe tumor. The patient had high levels of serum beta-human chorionic gonadotropin (b-HCG) and prolactine. Complete staging was negative for metastases. A typical left upper lobectomy with radical mediastinal lymph node dissection was performed...
2019: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/30602160/pseudoachalasia-as-first-manifestation-of-a-malignancy
#7
Elisabeth Fabian, Andreas J Eherer, Carolin Lackner, Christian Urban, Freyja-Maria Smolle-Juettner, Guenter J Krejs
Pseudoachalasia is a condition in which symptoms, radiologic, endoscopic, and manometric findings mimick idiopathic achalasia. About 4% of patients with a typical constellation for idiopathic achalasia will turn out to have pseudoachalasia, posing a major diagnostic challenge. A large spectrum of underlying causes of pseudoachalasia has been described. However, in about 70% of affected patients, this condition is caused by a malignancy (mostly adenocarcinoma of the esophagogastric junction or cardia). We describe a 16-year-old high school student referred for management of achalasia who turned out to have pseudoachalasia due to adenocarcinoma of the cardia...
January 2, 2019: Digestive Diseases
https://www.readbyqxmd.com/read/30588355/paraneoplastic-encephalopathy-in-a-patient-with-metastatic-lung-cancer-a-case-study
#8
REVIEW
Scott M Rowley
CASE STUDY RS, a 36-year-old female, presented to the emergency department (ED) of a large academic medical center upon the advice of her primary care provider because of 3 weeks of progressive mental status changes, weakness, and decreased oral intake. According to her husband, RS was diagnosed with stage IIIA large cell lung cancer 8 months earlier and was treated with concurrent chemotherapy (carboplatin, pemetrexed, and bevacizumab) and radiation therapy that was completed 4 months prior to admission. No other specific information about her treatment or outside health records was available...
March 2018: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/30574492/beneath-the-retinal-pigment-epithelium-histopathologic-findings-in-metastatic-extranodal-natural-killer-t-cell-lymphoma-nasal-type
#9
Atalie C Thompson, Chad M McCall, Alan D Proia
Purpose: To report a case of extranodal natural killer/T-cell lymphoma (ENKTCL), nasal type metastatic to the space beneath the retinal pigment epithelium (RPE) with coincident paraneoplastic lymphoma-associated retinopathy. Methods: Findings of clinical and histopathologic examination are presented with differential diagnoses and a literature review. Case Report: A 53-year-old man presented with bilateral blindness and had exudative retinal detachments overlying subretinal masses in both eyes...
November 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/30556876/the-role-of-let-7-and-hmga2-in-the-occurrence-and-development-of-lung-cancer-a-systematic-review-and-meta-analysis
#10
X-X Li, X Di, S Cong, Y Wang, K Wang
OBJECTIVE: To evaluate the prognostic role of microRNA let-7 in lung cancer and the relationship between the expression of HMGA2 and clinical significance of lung cancer by meta-analysis. MATERIALS AND METHODS: The studies on the correlation between the low expression of let-7 and the prognosis of lung cancer, and between the expression of HMGA2 and the occurrence and development of NSCLC were identified by searching PubMed, Web of the Science, Medline, Cochrane Library, Google Scholar, CNKI, CBM, and VIP databases...
December 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30555947/meningeal-carcinomatosis-presenting-with-leukoencephalopathy-like-imaging-findings
#11
Hiroshi Tsuji, Shioya Ayako, Norio Takayashiki, Toshiyuki Irie, Satoshi Itoi, Taisuke Kodama, Yuki Kaji, Ryota Matsuoka, Ryota Mashiko, Yasushi Shibata, Akiko Ishii, Yuko Siato, Akira Tamaoka
Meningeal carcinomatosis is a unique and rare form of metastasis observed in patients with malignant tumours. Diagnosis is simple when the primary lesion of the malignant tumour is clear, and when multiple miliary lesions are confirmed via cranial contrast MRI; however, many patients exhibit atypical imaging findings. In the present report, we discuss the case of a 72-year-old man who presented with subacute consciousness impairment and MRI findings suggestive of progressive, bilateral leukoencephalopathy-like lesions around the ventricles...
March 2019: ENeurologicalSci
https://www.readbyqxmd.com/read/30543927/a-large-screen-for-paraneoplastic-neurological-autoantibodies-diagnosis-and-predictive-values
#12
Lior Seluk, Alisa Taliansky, Hagith Yonath, Boris Gilburd, Howard Amital, Yehuda Shoenfeld, Shaye Kivity
BACKGROUND: Paraneoplastic neurological syndromes (PNS) are a group of syndromes that affect the central and peripheral neuromuscular system in association with cancer. Specific antibodies may assist in the diagnosis of PNS. The antibodies tested can be classified into those directed against intracellular neuronal proteins ("well characterized" PNS: Hu, Yo, RI, CV2, amphiphysin, Ma1, Ma2) and those directed against neural surface antigens (autoimmune encephalitis syndromes: NMDA, AMPA, LGI1, CASPR2, GABAR)...
December 10, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/30540734/an-elderly-man-with-gastric-cancer-saint-s-triad-and-heyde-s-syndrome
#13
Vitorino M Santos, Marcos V Carneiro, Viviane V P Soares, Samuel A Silva, Victor M Yano, Cacilda J F S Garcia
This case study describes a 71-year-old man with signet-ring cell gastric adenocarcinoma and malignant sigmoidal polyp; and typical features of Saint's triad and Heyde syndrome. He had digestive bleeding, two types of hernia, diverticulosis, arterial hypertension, malignant polyp, and antecedent of smoking, lung tuberculosis, and surgical correction of aortic valve stenosis. There is a hypothetical inverse relationship between herniosis and development of malignancy; however, the patient herein described presented gastric and sigmoidal cancers...
July 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/30498914/motor-neuron-involvement-in-anti-ma2-associated-paraneoplastic-neurological-syndrome
#14
Alberto Vogrig, Bastien Joubert, Aurélien Maureille, Laure Thomas, Emilien Bernard, Nathalie Streichenberger, Francois Cotton, Francois Ducray, Jérome Honnorat
OBJECTIVE: To present clinical, radiological, and pathological features of a cohort of patients with motor neuron involvement in association with anti-Ma2 antibodies (Ma2-Ab). METHODS: Retrospective case-series of patients with definite paraneoplastic neurological syndrome (PNS) and Ma2-Ab, and cases identified from a review of the literature. RESULTS: Among 33 Ma2-Ab patients referred between 2002 and 2016, we retrospectively identified three patients (9...
November 29, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30498610/beyond-the-dual-paraneoplastic-syndromes-of-small-cell-lung-cancer-with-adh-and-acth-secretion-a-case-report-with-literature-review-and-future-implications
#15
Krishna Adit Agarwal, Myat Han Soe
We present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistant metabolic alkalosis due to ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS). In this case report, we discuss the diagnostic challenges of dual paraneoplastic syndromes with SIADH and EAS, management of SCLC with paraneoplastic endocrinopathies, and their prognostic impact on SCLC...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/30483040/a-successfully-treated-case-of-intrahepatic-cholangiocarcinoma-with-exacerbation-of-dermatomyositis
#16
Jungo Yasuda, Shinji Onda, Hironori Shiozaki, Takeshi Gocho, Hiroaki Shiba, Katsuhiko Yanaga
Dermatomyositis (DM) is often found in conjunction with malignant tumors such as lung, cervical, and breast cancer. However, the association with intrahepatic cholangiocarcinoma (ICC) is extremely rare. Moreover, to our knowledge, there have been no previous reports of DM discovered because of exacerbation of DM. Our case was a 44-year-old female with dry cough, myalgia, and arthralgia. We performed hepatic resection for intrahepatic ICC. She was diagnosed with DM, and combination treatment with prednisolone and tacrolimus was started...
September 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/30460450/isolated-seizures-are-a-common-early-feature-of-paraneoplastic-anti-gaba-b-receptor-encephalitis
#17
Aurélien Maureille, Tanguy Fenouil, Bastien Joubert, Géraldine Picard, Véronique Rogemond, Anne-Laurie Pinto, Laure Thomas, François Ducray, Isabelle Quadrio, Dimitri Psimaras, Giulia Berzero, Jean-Christophe Antoine, Virginie Desestret, Jérôme Honnorat
OBJECTIVE: To report the clinical features and long-term outcome of 22 newly diagnosed paraneoplastic patients with GABAB receptor antibodies (GABAB R-Abs). METHODS: Retrospective clinical study of CSF-confirmed cases of GABAB R-Abs encephalitis. RESULTS: We identified 22 patients (4 female) with GABAB R-Abs, with a median age of 64 years (range 55-85). All were paraneoplastic: 20 small-cell lung cancer, one malignant thymoma, and one uncharacterized lung mass...
November 20, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30445363/the-utility-of-anti-sox2-antibodies-for-cancer-prediction-in-patients-with-paraneoplastic-neurological-disorders
#18
Paul Maddison, Maarten J Titulaer, Jan J Verschuuren, Paul Gozzard, Bethan Lang, Sarosh R Irani, Lidia Sabater, Francesc Graus, Andrea Murray, Caroline J Chapman
Antibodies to SOXB1 proteins in patients with paraneoplastic disorders are associated with small-cell lung cancer (SCLC), particularly in Lambert-Eaton myasthenic syndrome (LEMS). We aimed to establish if SOX2 antibodies could be used to identify SCLC and other tumours found in a range of paraneoplastic disorders and controls. SOX2 antibodies were detectable in 61% of patients with LEMS-SCLC, and in other paraneoplastic disorders, such as opsoclonus-myoclonus and paraneoplastic cerebellar degeneration, only when there was an underlying SCLC...
November 8, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/30428872/paraneoplastic-syndrome-as-the-presentation-of-limited-stage-small-cell-carcinoma
#19
Kia Nikoomanesh, Julian Choi, Sarkis Arabian
BACKGROUND: Small cell lung carcinoma (SCLC) is one of the deadliest forms of lung cancer due to its poor prognosis upon diagnosis, rapid doubling time, and affinity for metastasis. As 60-70% of patients with SCLC have disseminated disease upon presentation, it is imperative to determine the extent of disease burden for treatment. As a neuroendocrine carcinoma, clinicians must pay close attention to abnormal findings in a smoker that could lead to earlier diagnosis and better prognostication...
November 14, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/30405981/a-case-of-paraneoplastic-guillain-barr%C3%A3-syndrome-associated-with-squamous-cell-carcinoma-of-the-lung
#20
Danwei Wu, Anne Liu, Esther Baldinger, Alfred T Frontera
We report a case of a 61-year-old man with a history of squamous cell carcinoma of the lung presenting with rapidly progressive symmetric ascending weakness with areflexia. The weakness was quickly followed by respiratory decompensation requiring intubation. Lumbar puncture yielded cerebrospinal fluid with elevated protein (177 mg/dL), normal glucose (61 mg/dL), normal red blood cell count (0 per/µl), and normal white blood cell count (0 per/µL). Emergent magnetic resonance imaging of cervical, thoracic, and lumbar spine did not show evidence of metastatic disease, fracture, subluxation, or other causes of cord compression...
August 24, 2018: Curēus
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