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Straited muscle preferentially

Canan Ulusoy, Eunmi Kim, Erdem Tüzün, Ruksana Huda, Vuslat Yılmaz, Konstantinos Poulas, Nikos Trakas, Lamprini Skriapa, Athanasios Niarchos, Richard T Strait, Fred D Finkelman, Selin Turan, Paraskevi Zisimopoulou, Socrates Tzartos, Güher Saruhan-Direskeneli, Premkumar Christadoss
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness associated with acetylcholine receptor (AChR), muscle-specific receptor kinase (MuSK) or low-density lipoprotein receptor-related protein 4 (LRP4)-antibodies. MuSK-antibodies are predominantly of the non-complement fixing IgG4 isotype. The MuSK associated experimental autoimmune myasthenia gravis (EAMG) model was established in mice to investigate immunoglobulin (Ig) and cytokine responses related with MuSK immunity. C57BL/6 (B6) mice immunized with 30μg of recombinant human MuSK in incomplete or complete Freund's adjuvant (CFA) showed significant EAMG susceptibility (>80% incidence)...
April 2014: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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