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https://www.readbyqxmd.com/read/28928759/identification-of-biomarkers-for-defense-response-to-plasmopara-viticola-in-a-resistant-grape-variety
#1
Giulia Chitarrini, Evelyn Soini, Samantha Riccadonna, Pietro Franceschi, Luca Zulini, Domenico Masuero, Antonella Vecchione, Marco Stefanini, Gabriele Di Gaspero, Fulvio Mattivi, Urska Vrhovsek
Downy mildew (Plasmopara viticola) is one of the most destructive diseases of the cultivated species Vitis vinifera. The use of resistant varieties, originally derived from backcrosses of North American Vitis spp., is a promising solution to reduce disease damage in the vineyards. To shed light on the type and the timing of pathogen-triggered resistance, this work aimed at discovering biomarkers for the defense response in the resistant variety Bianca, using leaf discs after inoculation with a suspension of P...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28884717/-clinical-and-emotional-behavioral-characteristics-of-acute-and-chronic-low-back-pain
#2
E Z Yakupov, T S Grigoryeva
AIM: To analyze clinical and emotional/behavioral characteristics of acute and chronic low-back pain that significantly affect quality-of-life. MATERIAL AND METHODS: Fifty-three patients with pain syndromes were examined using the painDETECT questionnaire, the Visual Analog Scale for Pain, The McGill Pain Questionnaire and laboratory and instrumental methods of neurological assessment. RESULTS AND CONCLUSION: A 'picture of the patient with acute and chronic pain' was built, a group of patients with neuropathic component of pain was described...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28881531/-gene-expression-profiles-of-long-non-coding-rnas-in-human-degenerated-intervertebral-disc-tissue
#3
Z Y Sun, P Yan, S J Wang, H Liang, Y Li, D G Wang, J W Tian
Objective: To investigate the gene expression profiles of long non-coding RNAs (lncRNA)in human degenerated intervertebral disc degeneration (IDD). Methods: An lncRNA-mRNA microarray analysis of human nucleus pulposus (NP) was employed. Bioinformatics prediction was also applied to delineate the functional roles of the differentially expressed lncRNAs. Several lncRNAs and mRNAs were chosen for quantitative real-time PCR (qRT-PCR) validation. Results: A total of 1 570 lncRNAs expressed in degenerate group compared with the nondegenerate group...
September 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28881172/from-ideal-occlusion-to-dentofacial-deformity-and-back-to-ideal-an-osteochondroma-treatment-with-lingual-orthodontics
#4
Renato Parsekian Martins, Tatyane Ribeiro Mesquita, Ana Patrícia Sousa Pereira, Isabela Parsekian Martins, Daniel Serra Cassano, João Roberto Gonçalves
This original case report describes the morphologic changes caused by a mandibular condylar osteochondroma (OC) on a female patient and its treatment. The changes were identified by comparing her final records from a previous orthodontic treatment, without the presence of OC, to records taken before a second treatment, with a developed OC. The diagnostics and treatment for the OC and its consequences were described and discussed in this paper. Treatment included orthodontics with a lingual appliance, low condylectomy on the affected side, high condylectomy on the contralateral side, bilateral disc repositioning and orthognathic surgery...
September 7, 2017: Journal of Orthodontics
https://www.readbyqxmd.com/read/28872460/deficiency-in-kelch-protein-klhl31-causes-congenital-myopathy-in-mice
#5
James B Papizan, Glynnis A Garry, Svetlana Brezprozvannaya, John R McAnally, Rhonda Bassel-Duby, Ning Liu, Eric N Olson
Maintenance of muscle structure and function depends on the precise organization of contractile proteins into sarcomeres and coupling of the contractile apparatus to the sarcoplasmic reticulum (SR), which serves as the reservoir for calcium required for contraction. Several members of the Kelch superfamily of proteins, which modulate protein stability as substrate-specific adaptors for ubiquitination, have been implicated in sarcomere formation. The Kelch protein Klhl31 is expressed in a muscle-specific manner under control of the transcription factor MEF2...
September 5, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28866179/fabrication-and-in-vivo-evaluation-of-hydroxyapatite-carbon-nanotube-electrospun-fibers-for-biomedical-dental-application
#6
A S Khan, A N Hussain, L Sidra, Z Sarfraz, H Khalid, M Khan, F Manzoor, L Shahzadi, M Yar, I U Rehman
The aim was to synthesize bioactive electrospun fibers for biomedical and dental application with improved biocompatibility. In situ precipitation of nano-hydroxyapatite (nHA) was performed with various concentrations (0.5%, 1%, 2%, 3%, and 5% wt/wt) of functionalized multi-walled-carbon nanotubes (MWCNTs) by using microwave irradiation technique. The obtained composites were characterized by Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD), Thermogravimetric Analysis/Differential Scanning Calorimetry (TGA/DSC), and the cylindrical discs were made for mechanical testing...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865227/pathological-findings-in-low-field-magnetic-resonance-imaging-of-the-canine-spine-a-study-of-112-patients
#7
P Holak, J Głodek, M Mieszkowska, M Jałyński, Y Zhalniarovich, Z Adamiak
Magnetic resonance imaging (MRI) is a method of choice in diagnosing nervous system disorders. This paper presents the results of a study where selected segments of the canine spine were examined by low-field MRI in 112 patients. Images of pathological changes were obtained in spin echo (SE), fast spin echo (FSE) and hybrid contrast enhancement (3D HYCE) sequences. The cervical region of the spinal cord (C1-C5) was examined in 32 patients, the cervicothoracic region (C6-Th2)- in 14 patients, the thoracolumbar region (Th3-L3) - in 23 patients, and the lumbosacral region (L4-S3) - in 43 patients...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28853606/impact-of-the-quantity-of-intradiscal-cement-leak-on-the-progression-of-intervertebral-disc-degeneration
#8
B Jamjoom, S Patel, R Bommireddy, Z Klezl
Introduction We aim to assess the impact of the quantity of intradiscal cement leak during kyphoplasty on the rate of progression of degenerative changes in the affected disc. Methods Of 316 kyphoplasty procedures, we identified 32 episodes of intradiscal cement leak in 26 patients. The quantity of cement leaked was graded from I to IV. Disc degenerative changes were assessed at presentation and follow-up using radiographical scoring and magnetic resonance imaging (MRI) grading systems. Data for low-grade leaks (grade I) were compared with the medium- and high-grade leaks (grades II-IV) using a chi-squared test...
September 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28838343/in-vitro-evaluation-of-cytotoxic-anti-proliferative-anti-oxidant-apoptotic-and-anti-microbial-activities-of-cladonia-pocillum
#9
M Ersoz, Z M Coskun, B Acikgoz, I Karalti, G Cobanoglu, C Cesal
The aim of this study was to investigate the anti-proliferative, apoptotic, cytotoxic, and anti-oxidant effects of extracts from the lichen Cladonia pocillumon human breast cancer cells (MCF-7), and to characterize the anti-microbial features.  MCF-7 cells were treated with methanolic C. pocillum extract for 24h. The cytotoxicity of the extract was tested with MTT. Moreover, its anti-proliferative effects were examined with immunocytochemical method. Apoptosis and biochemical parameters were detected in MCF-7...
August 15, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28834886/therapeutic-efficacy-and-safety-of-laparoscopic-surgery-versus-microsurgery-for-varicocele-of-adult-males-a-meta-analysis
#10
Xueliang Wu, Qingbo Liu, Ruiming Zhang, Wei Wang, Yong Gao
OBJECTIVES: This study aimed to systemically evaluate the efficacy and safety of laparoscopy versus microsurgery in the surgical therapy of varicocele in male adults. METHODS: Relevant literature, published between January 1995 and October 2012, were searched in Pubmed/Medline database, OVID, EMBASE, Chinese Biology Medicine disc (CBMdisc), CNKI, CEBM\CCD, and Cochrane database. The newly published papers were also manually searched. Randomized controlled trials (RCT) related to the surgical interventions of varicocele were included, and full texts were obtained...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28829887/correlation-analysis-of-adamts-4-vcam-1-and-tak1-expression-in-cartilage-tissue-from-spine-tuberculosis
#11
Z X Qiu, Z S Sha, X M Che, M Y Wang
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) can effectively degrade articular cartilage matrix proteoglycan and damage the intervertebral disc of spinal tuberculosis patients, resulting in deterioration of the physical properties of articular cartilage. Transforming growth factor β activated kinase 1 (TAK1) is similar to vascular cell adhesion molecule 1 (VCAM-1) and closely related to a variety of pathophysiological processes. This study intended to explore the expression of ADAMTS-4, VCAM-1, and TAK1 in cartilage tissue obtained from spinal tuberculosis patients and their inter-relationships, aiming to provide new treatment approaches for spinal tuberculosis...
August 17, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28808312/the-synchronous-improvement-of-strength-and-plasticity-sisp-in-new-ni-co-based-disc-superalloys-by-controling-stacking-fault-energy
#12
H Xu, Z J Zhang, P Zhang, C Y Cui, T Jin, Z F Zhang
It is a great challenge to improve the strength of disc superalloys without great loss of plasticity together since the microstructures benefiting the strength always do not avail the plasticity. Interestingly, this study shows that the trade-off relationship between strength and plasticity can be broken through decreasing stacking fault energy (SFE) in newly developed Ni-Co based disc superalloys. Axial tensile tests in the temperature range of 25 to 725 °C were carried out in these alloys with Co content ranging from 5% to 23% (wt...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797595/effects-of-motion-segment-simulation-and-joint-positioning-on-spinal-loads-in-trunk-musculoskeletal-models
#13
F Ghezelbash, A H Eskandari, A Shirazi-Adl, N Arjmand, Z El-Ouaaid, A Plamondon
Musculoskeletal models represent spinal motion segments by spherical joints/beams with linear/nonlinear properties placed at various locations. We investigated the fidelity of these simplified models (i.e., spherical joints with/without rotational springs and beams considering nonlinear/linear properties) in predicting kinematics of the ligamentous spine in comparison with a detailed finite element (FE) model while considering various anterior-posterior joint placements. Using the simplified models with different joint offsets in a subject-specific musculoskeletal model, we computed local spinal forces during forward flexion and compared results with intradiscal pressure measurements...
July 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28792844/trpa1-ion-channel-stimulation-enhances-cardiomyocyte-contractile-function-via-a-camkii-dependent-pathway
#14
Spencer R Andrei, Monica Ghosh, Pritam Sinharoy, Souvik Dey, Ian N Bratz, Derek S Damron
RATIONALE: Transient receptor potential channels of the ankyrin subtype-1 (TRPA1) are non-selective cation channels that show high permeability to calcium. Previous studies from our laboratory have demonstrated that TRPA1 ion channels are expressed in adult mouse ventricular cardiomyocytes (CMs) and are localized at the z-disk, costamere and intercalated disk. The functional significance of TRPA1 ion channels in the modulation of CM contractile function have not been explored. OBJECTIVE: To identify the extent to which TRPA1 ion channels are involved in modulating CM contractile function and elucidate the cellular mechanism of action...
August 9, 2017: Channels
https://www.readbyqxmd.com/read/28760032/minimally-invasive-transforaminal-lumbar-interbody-fusion-with-expandable-versus-static-interbody-devices-radiographic-assessment-of-sagittal-segmental-and-pelvic-parameters
#15
Ammar H Hawasli, Jawad M Khalifeh, Ajay Chatrath, Chester K Yarbrough, Wilson Z Ray
OBJECTIVE Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has been adopted as an alternative technique to hasten recovery and minimize postoperative morbidity. Advances in instrumentation technologies and operative techniques have evolved to maximize patient outcomes as well as radiographic results. The development of expandable interbody devices allows a surgeon to perform MIS-TLIF with minimal tissue disruption. However, sagittal segmental and pelvic radiographic outcomes after MIS-TLIF with expandable interbody devices are not well characterized...
August 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28746202/assessing-diagnostic-value-of-contrast-enhanced-ultrasound-and-contrast-enhanced-computed-tomography-in-detecting-small-hepatocellular-carcinoma-a-meta-analysis
#16
COMPARATIVE STUDY
Jiasheng Huang, Wei Chen, Shanwen Yao
BACKGROUND: This study aimed to compare the diagnostic values of contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT) in detecting small hepatocellular carcinoma (SHCC). METHODS: A series of related articles from 2001 to 2015 were searched in PubMed and Embase databases. Data from selected articles were pooled to analyze the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve using Meta-DiSc software...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28735356/evaluation-of-anthelmintic-antimicrobial-and-antioxidant-activity-of-chenopodium-album
#17
Bashir A Lone, M Z Chishti, Fayaz Ahmad Bhat, Hidayatullah Tak, Suhaib A Bandh, Abida Khan
The objective of this study was to evaluate the anthelmintic, antimicrobial and antioxidant activities of Chenopodium album against gastrointestinal nematodes of sheep and some pathogenic microbes. A worm motility inhibition assay was used for in vitro study, and a faecal egg count reduction assay was used for an in vivo study. Various concentrations ranging from 100 to 500 μg/ml of the extract were subjected to antimicrobial screening by disc diffusion method against four selected bacterial (Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas multocida and Escherichia coli) and two fungal (Aspergillus flavus and Candida albicans) strains in order to estimate the medicinal potential of the herb...
July 22, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28732005/filamin-actin-binding-and-titin-binding-fulfill-distinct-functions-in-z-disc-cohesion
#18
Nicanor González-Morales, Tristan K Holenka, Frieder Schöck
Many proteins contribute to the contractile properties of muscles, most notably myosin thick filaments, which are anchored at the M-line, and actin thin filaments, which are anchored at the Z-discs that border each sarcomere. In humans, mutations in the actin-binding protein Filamin-C result in myopathies, but the underlying molecular function is not well understood. Here we show using Drosophila indirect flight muscle that the filamin ortholog Cheerio in conjunction with the giant elastic protein titin plays a crucial role in keeping thin filaments stably anchored at the Z-disc...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28731058/multicenter-study-of-pars-plana-vitrectomy-for-optic-disc-pit-maculopathy-macpit-study
#19
R Avci, Z Kapran, Ş Ozdek, M Y Teke, O Oz, D Guven, S Yilmaz, B Kaderli, A H Durukan, G Sobaci, Y B Unver, L Akduman, S Kaynak, I Dogan, U U Inan
PurposeTo evaluate surgical intervention with pars plana vitrectomy (PPV) for correction of optic disc pit maculopathy (ODP-M).Patients and methodsRetrospective chart review from 13 centres of 51 eyes of 50 patients with ODP-M who underwent PPV between 2002-2014. Anatomic and final best-corrected visual acuity (BCVA) outcomes were evaluated for all cases with different adjuvant techniques.ResultsThere were 23 males and 27 females with median age 25.5 (6-68) years. Preoperative median foveal thickness was 694...
September 2017: Eye
https://www.readbyqxmd.com/read/28717008/the-novel-cardiac-z-disc-protein-cefip-regulates-cardiomyocyte-hypertrophy-by-modulating-calcineurin-signaling
#20
Franziska Dierck, Christian Kuhn, Claudia Rohr, Susanne Hille, Julia Braune, Samuel Sossalla, Sibylle Molt, Peter F M van der Ven, Dieter O Fürst, Norbert Frey
The z-disc is a structural component at the lateral borders of the sarcomere and is important for mechanical stability and contractility of both cardiac and skeletal muscles. Of note, the sarcomeric z-disc also represents a nodal point in cardiomyocyte function and signaling. Mutations of numerous z-disc proteins are associated with cardiomyopathies and muscle diseases. To identify additional z-disc proteins that might contribute to cardiac disease, we employed an in silico screen for cardiac-enriched cDNAs...
September 15, 2017: Journal of Biological Chemistry
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