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https://www.readbyqxmd.com/read/29777134/zebrafish-vcap1x2-regulates-cardiac-contractility-and-proliferation-of-cardiomyocytes-and-epicardial-cells
#1
Fang-Chi Hsieh, Yu-Fen Lu, Ian Liau, Chien-Chang Chen, Chao-Min Cheng, Chung-Der Hsiao, Sheng-Ping L Hwang
Sarcomeric signaling complexes are important to sustain proper sarcomere structure and function, however, the mechanisms underlying these processes are not fully elucidated. In a gene trap experiment, we found that vascular cell adhesion protein 1 isoform X2 (VCAP1X2) mutant embryos displayed a dilated cardiomyopathy phenotype, including reduced cardiac contractility, enlarged ventricular chamber and thinned ventricular compact layer. Cardiomyocyte and epicardial cell proliferation was decreased in the mutant heart ventricle, as was the expression of pAKT and pERK...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29774118/proteomic-profiling-of-skeletal-and-cardiac-muscle-in-cancer-cachexia-alterations-in-sarcomeric-and-mitochondrial-protein-expression
#2
Angie M Y Shum, Anne Poljak, Nicholas L Bentley, Nigel Turner, Timothy C Tan, Patsie Polly
Background: Cancer cachexia is observed in more than 50% of advanced cancer patients, and impairs quality of life and prognosis. A variety of pathways are likely to be dysregulated. Hence, a broad-spectrum understanding of the disease process is best achieved by a discovery based approach such as proteomics. Results: More than 300 proteins were identified with > 95% confidence in correct sequence identification, of which 5-10% were significantly differentially expressed in cachectic tissues ( p -value of 0...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29764039/-long-term-efficacy-of-cervical-artificial-disc-replacement-for-cervical-degenerative-diseases
#3
Q P Song, W Tian, D He, X Han, N Zhang, J C Wang, Z C Li
Objective: To evaluate the long-term efficacy of cervical artificial disc replacement for patients with cervical disc herniation and degenerative cervical canal stenosis. Methods: Total of sixty-eight patients underwent single-level Bryan artificial disc replacement in Beijing Jishuitan Hospital from December 2003 to December 2007 with a minimum 10-year follow-up were retrospectively analyzed. There were 43 males and 25 females with a mean age of (46±8) years. According to preoperative CT and MRI, the patients were divided into two groups: 27 patients in cervical disc herniation group and 41 patients in degenerative cervical canal stenosis group...
May 8, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29763726/susceptibility-of-ruminal-bacteria-isolated-from-large-and-small-ruminant-to-multiple-conventional-antibiotics
#4
Abdelfattah Z M Salem, Ameer Khusro, Mona M Y Elghandour, Jaime Olivares-Pérez, Saúl Rojas-Hernandez, Régulo Jiménez-Guillén
The pivotal aim of the present context was to isolate diversified group of bacteria from the ruminants and to evaluate their antibiogram pattern against 22 antibiotics of 14 different classes. The bacterial isolates from small and large ruminant (sheep, cattle, and calves) were isolated from the rumen based on various colonies morphology, and subjected for preliminary antibiotics susceptibility assay using disc diffusion method. The most sensitive isolates (based on zone of inhibition) were selected for determining the minimum inhibitory concentration (MIC) of each antibiotic ranging from 1 to 256 μg/mL...
May 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29753897/comparison-of-multilevel-cervical-disc-replacement-and-multilevel-anterior-discectomy-and-fusion-a-systematic-review-of-biomechanical-and-clinical-evidence
#5
REVIEW
Yang Li, Hangkai Shen, Kamran Z Khan, Shushu Fang, Zhenhua Liao, Weiqiang Liu
The present study aimed to comprehensively compare the clinical and biomechanical efficiency of combined anterior cervical discectomy and fusion (ACDF) with the anterior cervical disc replacement (ACDR) for treatment of multilevel cervical disc diease (CDD) using a meta-analysis and systematical review. A literature search was performed using Pubmed, MEDLINE, EMBASE and the Cochrane Library for papers published between January 1960 and December 2017. Both clinical and biomechanical parameters were analyzed...
May 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29751219/the-physical-and-biochemical-effects-of-pre-rigor-high-pressure-processing-of-beef
#6
James D Morton, Hannah Y-Y Lee, R Grant Pearson, Roy Bickerstaffe
High pressure processing (HPP) of pre-rigor longissimus thoracis (strip loin) from prime and bull animals substantially decreased the shear force and improved consumer eating attributes of the final meat product. The improved tenderness in both prime and bull meat was associated with a lower myofibrillar fragmentation index and reduced calpain 1 activity which indicated the mechanism of tenderisation was different from that which occurred in chill aged meat. Light microscopy showed disruption to the fibre packing within the muscle and electron microscopy confirmed significant disruption of the Z discs and M lines and disappearance of the A lines...
April 24, 2018: Meat Science
https://www.readbyqxmd.com/read/29748204/a-qualitative-and-quantitative-correlation-study-of-lumbar-intervertebral-disc-degeneration-using-glycosaminoglycan-chemical-exchange-saturation-transfer-pfirrmann-grade-and-t1-%C3%AF
#7
O Togao, A Hiwatashi, T Wada, K Yamashita, K Kikuchi, C Tokunaga, J Keupp, M Yoneyama, H Honda
BACKGROUND AND PURPOSE: Glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging allows the direct measurement and mapping of glycosaminoglycans. In this study, we aimed to evaluate the usefulness of gagCEST imaging in the quantitative assessment of intervertebral disc degeneration in a comparison with Pfirrmann grade and T1-ρ measurements. MATERIALS AND METHODS: Ninety-six lumbar intervertebral discs in 24 volunteers (36.0 ± 8.5 years of age, 21 men and 3 women) were examined with both gagCEST imaging and T1-ρ measurements...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29730176/a-comparative-study-between-hot-melt-extrusion-and-spray-drying-for-the-manufacture-of-anti-hypertension-compatible-monolithic-fixed-dose-combination-products
#8
J F Kelleher, G C Gilvary, A M Madi, D S Jones, S Li, Y Tian, A Almajaan, Z Senta-Loys, G P Andrews, A M Healy
The purpose of this work was to investigate the application of different advanced continuous processing techniques (hot melt extrusion and spray drying) to the production of fixed-dose combination (FDC) monolithic systems comprising of hydrochlorothiazide and ramipril for the treatment of hypertension. Identical FDC formulations were manufactured by the two different methods and were characterised using powder x-ray diffraction (PXRD) and modulated differential scanning calorimetry (mDSC). Drug dissolution rates were investigated using a Wood's apparatus, while physical stability was assessed on storage under controlled temperature and humidity conditions...
May 3, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29716878/report-phytochemical-screening-and-antimicrobial-activities-of-red-silk-cotton-tree-bombax-ceiba-l
#9
Syed Sadaqat Shah, Syed Salim Shah, Arshad Iqbal, Sajjad Ahmed, Wisal Muhammad Khan, Saddam Hussain, Zhijian Li
The present study was conducted to investigate the phytochemical screening and antimicrobial activities of stem bark of Bombax ceiba L. The methanol extract was subjected to qualitative phytochemical screening using standard procedures. The results indicated the presence of alkaloids, tannins, glycosides, reducing sugar, saponins, phlobatanins and terpenoids. The antimicrobial activity was measured by disc diffusion method. Data revealed that Pseudomonas aeruginosa was inhibited by both methanol and ethanol extracts at the concentration of 2mg disc-1 {21...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29713429/what-is-the-changing-frequency-of-diamond-burs
#10
Faruk Emir, Simel Ayyildiz, Cem Sahin
PURPOSE: The purpose of this study was to determine the changing frequency of a diamond bur after multiple usages on 3 different surfaces. MATERIALS AND METHODS: Human premolar teeth (N = 26), disc shaped direct metal laser sintered CoCr (N = 3) and zirconia specimens (N = 3) were used in this study. Groups named basically as Group T for teeth, Group M for CoCr, and Group Z for zirconia. Round tapered black-band diamond bur was used. The specimens were randomly divided into three groups and placed with a special assembly onto the surveyor...
April 2018: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/29705943/critical-contribution-of-ripk1-mediated-mitochondrial-dysfunction-and-oxidative-stress-to-compression-induced-rat-nucleus-pulposus-cells-necroptosis-and-apoptosis
#11
Songfeng Chen, Xiao Lv, Binwu Hu, Lei Zhao, Shuai Li, Zhiliang Li, Xiangcheng Qing, Hongjian Liu, Jianzhong Xu, Zengwu Shao
The aim of this study was to investigate whether RIPK1 mediated mitochondrial dysfunction and oxidative stress contributed to compression-induced nucleus pulposus (NP) cells necroptosis and apoptosis, together with the interplay relationship between necroptosis and apoptosis in vitro. Rat NP cells underwent various periods of 1.0 MPa compression. To determine whether compression affected mitochondrial function, we evaluated the mitochondrial membrane potential, mitochondrial permeability transition pore (mPTP), mitochondrial ultrastructure and ATP content...
April 28, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29704984/antibacterial-activity-of-extracted-bioactive-molecules-of-schinus-terebinthifolius-ripened-fruits-against-some-pathogenic-bacteria
#12
M Z M Salem, M El-Hefny, H M Ali, H O Elansary, R A Nasser, A A A El-Settawy, N El Shanhoery, N A Ashmawy, A Z M Salem
The aim of this work is to identify the chemical constituents and the bioactivity of essential oil (EO), acetone extract (ACE) and n-hexane extract (HexE) of S. terebinthifolius ripened fruits using GC-MS. Total phenolic content and antioxidant activity of extracts were determined using the Folin-Ciocalteu and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assays, respectively. The toxicity against the growth of Acinetobacter baumannii, Bacillus subtilis, Escherichia coli, Micrococcus flavus, Pseudomonas aeruginosa, Sarcina lutea, and Staphylococcus aureus was determined with measuring the inhibition zones (IZs) using the disc diffusion method at the concentrations between 125 and 2000 μg/mL, also, the minimum inhibitory concentrations (MICs) using 96-well micro-plates and ranged from 4 to 2000 μg/mL...
April 26, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29643538/-anterior-cervical-discectomy-and-fusion-to-treat-cervical-spondylosis-with-sympathetic-symptoms
#13
H Liu, L Yue, S L Chen, B Hu, C D Li, X D Yi, H Li, H L Lu, Y Wang, Z R Yu, H L Sun, S J Wang, Y Zhao, L T Qi, R Wang
OBJECTIVE: To investigate the clinical effectiveness of polytheretherketone (PEEK) cages assisted anterior cervical discetomy and fusion (ACDF) to treat cervical spondylosis with sympathetic symptoms. METHODS: Retrospective analysis was undertaken for 39 patients who were diagnosed as cervical spondylosis with sympathetic symptoms and underwent ACDF with PEEK cages. Radiographs obtained before surgery, after surgery, and at the final follow-up were assessed for quality of fusion...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29629185/evaluation-of-spine-mris-in-athletes-participating-in-the-rio-de-janeiro-2016-summer-olympic-games
#14
Michael S Wasserman, Ali Guermazi, Mohamed Jarraya, Lars Engbretsen, Mohamad AbdelKader, Frank W Roemer, Daichi Hayashi, Michel D Crema, Asim Z Mian
Background/aim: In high-level Olympic athletes, many spinal pathologies arise from overuse, while others are the result of acute injury. Our aim is to analyse the epidemiology of spinal pathologies detected on MRI in athletes participating in the 2016 Rio de Janeiro Summer Olympics. Methods: In this retrospective study, all spine MRIs performed during the 2016 Rio Games were analysed. Descriptive data from the MRIs were tabulated and analysed for disc degeneration, spinal canal and/or neural foraminal narrowing, and acute/chronic fractures...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29526622/zaleplon-loaded-bi-layered-chronopatch-a-novel-buccal-chronodelivery-approach-to-overcome-circadian-rhythm-related-sleep-disorder
#15
Michael M Farag, Nevine S Abd El Malak, Soad A Yehia
The aim of this study was to develop a novel buccal bi-layered chronopatch capable of eliciting pulsatile release pattern of drugs treating diseases with circadian rhythm related manifestation. Zaleplon (ZLP) was used as a model drug intended to induce sleep and to treat middle of night insomnia. The chronopatch was prepared adopting double casting technique. The first layer was composed of a controlled release patch containing ZLP-Precirol melt granules intended to release ZLP in a sustained manner to maintain sleep and to prevent early morning awakening...
May 5, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29518874/-the-association-between-corneal-biomechanical-parameters-and-visual-field-progression-in-patients-with-normal-tension-glaucoma
#16
B B Li, Y Cai, Y Z Pan, M Li, Y Fang, T Tian, X M Yan
Objective: To evaluate the association between corneal biomechanical parameters and visual field (VF) progression in normal tension glaucoma (NTG) using the Corvis-ST device, and to evaluate the ability of corneal biomechanical parameters to predict the VF progression. Methods: Corneal biomechanical parameters of newly diagnosed NTG patients were obtained using Corvis-ST in the baseline follow-up visit. The VF progression was defined as a 4-point increase in the Advanced Glaucoma Intervention Study (AGIS) score compared to the baseline in three consecutive follow-up visits (per 3-6 months)...
March 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29508067/three-dimensional-reconstruction-of-the-intercalated-disc-including-the-intercellular-junctions-by-applying-volume-scanning-electron-microscopy
#17
Bieke Vanslembrouck, Anna Kremer, Benjamin Pavie, Frans van Roy, Saskia Lippens, Jolanda van Hengel
The intercalated disc (ID) contains different kinds of intercellular junctions: gap junctions (GJs), desmosomes and areae compositae, essential for adhesion and communication between adjacent cardiomyocytes. The junctions can be identified based on their morphology when imaged using transmission electron microscopy (TEM), however, only with very limited information in the z-dimension. The application of volume EM techniques can give insight into the three-dimensional (3-D) organization of complex biological structures...
March 5, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29504365/layering-poly-lactic-co-glycolic-acid-based-electrospun-membranes-and-co-culture-cell-sheets-for-engineering-temporomandibular-joint-disc
#18
C-H Wang, S Wang, B Zhang, X-Y Zhang, X-J Tong, H-M Peng, X-Z Han, C Liu
The temporomandibular joint disk (TMJD) lacks blood vessels and is characterized by slow self-repair. Qualitative lesions in TMJD are difficult to repair. In this study, electrospun poly (lactic-co-glycolic acid) (PLGA) scaffolds were used to reconstruct temporomandibular joint discs by tissue engineering. Rabbit temporomandibular joint disc cells (TMJDCs) and rabbit synovium-derived mesenchymal stem cells (SMSCs) were co-cultured in 1:1 ratios. Cell sheets were induced by ascorbic acid incubated with electrospun PLGA scaffolds for 14 days in the presence (10 ng/ml in culture medium) or absence of TGF-β3...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29483728/-comparison-of-the-translucency-and-color-masking-effect-of-the-zirconia-ceramics-made-by-milling-and-gel-deposition
#19
X Y Cui, D Tong, X Z Wang, Z J Shen
OBJECTIVE: Three kinds of zirconia specimens were made respectively by milling of the prisintered blocks and by three dimensional (3D) gel deposition for in vitro evaluation of their optical translucency under three different thicknesses and their color masking effect on discolored teeth. The study aims for establishing the principle for guiding the materials selection in clinical practice. METHODS: Ninety A2-colored zirconia disc specimens with diameter of 14 mm were prepared and were divided into three groups (n=30)...
February 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29417254/assessment-and-comparison-of-phytochemical-constituents-and-biological-activities-of-bitter-bean-parkia-speciosa-hassk-collected-from-different-locations-in-malaysia
#20
Ali Ghasemzadeh, Hawa Z E Jaafar, Mohamad Fhaizal Mohamad Bukhori, Mohd Hafizad Rahmat, Asmah Rahmat
BACKGROUND: Parkia speciosa seeds are a common ingredient in Malay cuisine with traditional interest because of its medicinal importance and content of health-promoting phytochemicals. This study evaluated the phytochemical constituents and biological activities (antioxidant and antibacterial activities) of Parkia speciosa Hassk seeds collected from three different regions of Malaysia (Perak, Negeri Sembilan and Johor). Phytochemical constituents (total flavonoid and total phenolic) were measured using the spectrophotometric method, and individual flavonoids and phenolic acids were identified using ultra-high-performance liquid chromatography...
February 7, 2018: Chemistry Central Journal
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