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https://www.readbyqxmd.com/read/28324165/lipid-phenol-and-carotenoid-changes-in-bianca-grapevine-leaves-after-mechanical-wounding-a-case-study
#1
Giulia Chitarrini, Luca Zulini, Domenico Masuero, Urska Vrhovsek
Metabolic changes can occur in plants in response to abiotic stress. Extensive use of leaf discs (mechanical wounding) in studies regarding the effect on the biochemical response of the grapevine to different types of biotic stress makes it necessary to understand metabolic perturbation after injury. In this study, we investigate how mechanical wounding can affect the metabolism of grapevine leaf tissue using Bianca variety as case study. Two sizes of leaf discs (1.1 and 2.8 cm in diameter) were excised from leaves, and phenol, lipid and carotenoid perturbation were investigated 0, 6, 12, 24, 48, 96 and 120 h post cutting...
March 21, 2017: Protoplasma
https://www.readbyqxmd.com/read/28279050/-adaptive-remodeling-of-temporomandibular-joint-following-anterior-disc-displacement-and-treatment-decision-making
#2
Z Y Gu
Anterior disc displacement (ADD) of temporomandibular joint (TMJ) is one of the common oral diseases. The TMJ can be remodeled after disc displacement. The author's recent studies show that remodeled bilaminar zone is similar to the disc in composition and functions. The remodeled condyle can match the disc-like bilaminar zone. The new disc-condylar relationship can, to a certain extent, restore the function of the TMJ. Based on these studies, the author believes that the adaptive remodeling in TMJ has important guiding significance for clinical treatment and discusses the views of the treatment decision for various stages of temporomandibular disorders...
March 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28270293/bone-marrow-imaging-by-third-generation-dual-source-dual-energy-ct-using-virtual-noncalcium-technique-for-assessment-of-diffuse-infiltrative-lesions-of-multiple-myeloma
#3
Qin Wang, Zhaoyong Sun, Shuo Li, Haibo Zhang, Jian Li, L U Zhang, Huadan Xue, Zhengyu Jin
Objective To evaluate the value of bone marrow imaging by third-generation dual-source dual-energy CT(DSDECT) using virtual noncalcium(VNCa) technique for the assessment of diffuse infiltrative lesions of multiple myeloma(MM). Methods From December 2015 to June 2016,31 patients with plasma disorders at our center were prospectively recruited and received whole-body imaging with third-generation DSDECT and MRI. CT numbers of vertebrae were measured on VNCa images as well as regular CT images. Correlation between VNCa CT numbers and MRI signal intensities of the vertebrae was evaluated...
February 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28269794/myofibrillar-myopathies-new-perspectives-from-animal-models-to-potential-therapeutic-approaches
#4
Sabrina Batonnet-Pichon, Anthony Behin, Eva Cabet, Florence Delort, Patrick Vicart, Alain Lilienbaum
Myofibrillar myopathies (MFMs) are muscular disorders involving proteins that play a role in the structure, maintenance processes and protein quality control mechanisms closely related to the Z-disc in the muscular fibers. MFMs share common histological characteristics including progressive disorganization of the interfibrillar network and protein aggregation. Currently no treatment is available. In this review, we describe first clinical symptoms associated with mutations of the six genes (DES, CRYAB, MYOT, ZASP, FLNC and BAG3) primary involved in MFM and defining the origin of this pathology...
2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/28260752/antibiotic-resistance-new-challenge-in-the-management-of-bacterial-eye-infections
#5
A K Talukder, Z Sultana, I Jahan, M Khanam, M Rahman, M F Rahman, M B Rahman
Ophthalmologists are still facing difficulties in managing bacterial eye infections. The study was designed for the isolation and identification of bacteria from infected eyes and observation of the sensitivity and resistant pattern. This cross sectional study was performed among 160 patients of suspected bacterial eye infection at Dr. K. Zaman BNSB Eye Hospital, Mymensingh and Department of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensingh from March, 2010 to June, 2014. After collection of the samples from suspected infected eyes, it was nourished into nutrient broth in shaking incubator for three hours and then cultured into nutrient agar media followed by Mannitol salt agar, MacConkey's agar and blood agar...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28256482/the-antifungal-activity-and-cytotoxicity-of-silver-containing-denture-base-material
#6
A Kurt, G Erkose-Genc, M Uzun, Z Emrence, D Ustek, G Isik-Ozkol
OBJECTIVE: Denture base materials are susceptible to fungal adhesion, which is an important etiological issue in the pathogenesis of denture stomatitis. The purpose of this in vitro study was to evaluate the antifungal activity and cytotoxicity of denture base material containing silver microparticles. MATERIALS AND METHODS: The polymethyl methacrylate (PMMA) denture base material was used, and silver microparticles were added to the polymer powder in different concentrations by volume (0%, 0...
March 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28241721/-radiographic-assessment-of-vertebral-artery-injury-in-anterior-cervical-surgery-in-healthy-adults
#7
H L Wang, L Jiang, F Z Lyu, X S Ma, X L Xia, J Y Jiang
Objectives: To study the relationship between the anatomical parameters of transverse foramen and intervertebral discs in the cross-section of the cervical spine in healthy adults, and to evaluate the risk of vertebral artery injury in the anterior cervical spine surgery. Methods: There were 24 healthy adults(12 male, 12 female) underwent neck CT angiography with clear vertebral artery and the adjacent structure imaging from June to December 2014 in Huashan Hospital, Fudan University. The anatomical parameters of vertebral artery V2 segment with lower cervical vertebrae and intervertebral discs were measured by cross-sectional images of C(3-6)...
March 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28222400/antiprotozoal-antimycobacterial-and-anti-inflammatory-evaluation-of-cnidoscolus-chayamansa-mc-vaugh-extract-and-the-isolated-compounds
#8
Mariana Z Pérez-González, Gabriel A Gutiérrez-Rebolledo, Lilián Yépez-Mulia, Irma S Rojas-Tomé, Julieta Luna-Herrera, María A Jiménez-Arellanes
Cnidoscolus chayamansa is a medicinal and edible plant known as Chaya, is commonly used as an anti-inflammatory, antiprotozoal, antibacterial agent and as a remedy for respiratory illness, gastrointestinal disorders, and vaginal infections related with the inflammation process. In this paper, we describe the plant's phytochemical analysis and biological activities (antimycobacterial, antibacterial, antiprotozoal, and anti-inflammatory properties) of the CHCl3:MeOH (1:1) leaves extract and isolated compounds, as well as the acute and sub-acute toxic effects...
February 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28173652/-clinical-and-genetic-analysis-of-a-family-with-joubert-syndrome-type-10-caused-by-ofd1-gene-mutation
#9
C Meng, K H Zhang, J Ma, X Gao, K Yu, H Y Zhang, Y Wang, Z X Zhang, W G Li, Y Liu, Z T Gai
Objective: To investigate the genetic cause for a family with multiorgan dysplasia and "molar tooth sign" on MRI image. Method: The patient, a 3 months and 21 days old boy, was clinically examined and the medical history of his family was collected. Next generation sequencing was performed to analyze his clinical and genetic causes. Result: Clinical manifestation of the child displayed multiorgan dysplasia, such as six finger deformity, short limbs, coloboma of optic disc and choroid, situs inversus.Cranial MRI showed "molar tooth sign" ...
February 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28162962/in-vitro-synergistic-antibacterial-activity-of-the-essential-oil-from-zingiber-cassumunar-roxb-against-extensively-drug-resistant-acinetobacter-baumannii-strains
#10
Wongwarut Boonyanugomol, Kairin Kraisriwattana, Kamolchanok Rukseree, Kraisorn Boonsam, Panchaporn Narachai
In this study, we determined the antibacterial and synergistic activities of the essential oil from Zingiber cassumunar against the extensively drug-resistant (XDR) Acinetobacter baumannii strains. The antibacterial and synergistic properties of the essential oil from Z. cassumunar were examined by agar disc diffusion tests. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated by broth microdilution using the resazurin assay. The in vitro time-kill antibacterial kinetics was analyzed using the plate count technique...
February 2, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28152274/fe-3-seo42-dual-doped-nano-hydroxyapatite-a-novel-material-for-biomedical-applications
#11
Ammar Z Alshemary, Ahmet Engin Pazarceviren, Aysen Tezcaner, Zafer Evis
Dual ions substituted hydroxyapatite (HA) received attention from scientists and researchers in the biomedical field owing to their excellent biological properties. This paper presents a novel biomaterial, which holds potential for bone tissue applications. Herein, we have successfully incorporated ferric (Fe(3+) )/selenate (SeO42-) ions into the HA structure (Ca10-x-y Fey (PO4 )6-x (SeO4 )x (OH)2-x-y Oy ) (Fe-SeHA) through a microwave refluxing process. The Fe-SeHA materials were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and field emission scanning electron microscopy (FESEM)...
February 2, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28142162/dark-adaptation-in-patients-with-primary-open-angle-glaucoma-pseudoexfoliation-glaucoma-and-childhood-glaucoma
#12
G D Panos, M M Moschos, N Kozeis, R R Deshmukh, K Mansouri, T Shaarawy, Z Gatzioufas
Purpose To investigate the state of dark adaptation and macular blood flow in different forms of glaucoma. Methods Eighteen eyes of 18 patients with primary open-angle glaucoma, 14 eyes of 14 patients with pseudoexfoliation glaucoma, and 10 eyes of 10 patients with childhood glaucoma (CG) were examined by means of dark adaptometry, scanning-laser retinal flowmetry, and retinal tomography. Results All glaucomatous eyes had comparable optic disc excavation (one-way ANOVA, p = 0.138). Eyes with CG had significantly lower best-corrected visual acuity than the other groups (Tukey, all p < 0...
January 31, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28114419/whole-proteome-analyses-on-ruminiclostridium-cellulolyticum-show-a-modulation-of-the-cellulolysis-machinery-in-response-to-cellulosic-materials-with-subtle-differences-in-chemical-and-structural-properties
#13
Nelly Badalato, Alain Guillot, Victor Sabarly, Marc Dubois, Nina Pourette, Bruno Pontoire, Paul Robert, Arnaud Bridier, Véronique Monnet, Diana Z Sousa, Sylvie Durand, Laurent Mazéas, Alain Buléon, Théodore Bouchez, Gérard Mortha, Ariane Bize
Lignocellulosic materials from municipal solid waste emerge as attractive resources for anaerobic digestion biorefinery. To increase the knowledge required for establishing efficient bioprocesses, dynamics of batch fermentation by the cellulolytic bacterium Ruminiclostridium cellulolyticum were compared using three cellulosic materials, paper handkerchief, cotton discs and Whatman filter paper. Fermentation of paper handkerchief occurred the fastest and resulted in a specific metabolic profile: it resulted in the lowest acetate-to-lactate and acetate-to-ethanol ratios...
2017: PloS One
https://www.readbyqxmd.com/read/28097935/finite-element-simulations-of-the-head-brain-responses-to-the-top-impacts-of-a-construction-helmet-effects-of-the-neck-and-body-mass
#14
John Z Wu, Christopher S Pan, Bryan M Wimer, Charles L Rosen
Traumatic brain injuries are among the most common severely disabling injuries in the United States. Construction helmets are considered essential personal protective equipment for reducing traumatic brain injury risks at work sites. In this study, we proposed a practical finite element modeling approach that would be suitable for engineers to optimize construction helmet design. The finite element model includes all essential anatomical structures of a human head (i.e. skin, scalp, skull, cerebrospinal fluid, brain, medulla, spinal cord, cervical vertebrae, and discs) and all major engineering components of a construction helmet (i...
January 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28072995/-the-effects-of-platelet-rich-fibrin-extract-on-mc3t3-e1-cells-cultured-on-the-titanium-discs
#15
X J Zhang, S Xu, W Y Meng, H J Xiao, K Dong, Z H Liu
Objective: To evaluate the effect of platelet-rich fibrin extract (PRFe) on the adhesion, proliferation and differentiation of MC3T3-E1 cells cultured on the titanium discs. Methods: Samples were divided into experimental group (P) and control group (D). Group P used the α-minimal essential medium (α-MEM) containing PRFe (0.5%), while group D used only the α-MEM. Cell adhesion and cytoskeleton were observed using scanning electron microscopy (SEM) and laser scanning confocal microscopy (LSCM). Methyl thiazolyl tetrazolium (MTT) assay to detect the number of the osteoblasts at 1, 3, 5, 7 d; the activity of alkaline phosphatase (ALP) to detect the differentiation of osteoblast at 1, 3, 5, 7 d; the level of osteogenetic biomarkers core-binding factorα1 (cbfα1) and osteocalcin (OCN) were quantified by quantitative real-time PCR (qRT-PCR) at 3 and 7 d...
January 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28028127/myofibrillar-z-discs-are-a-protein-phosphorylation-hot-spot-with-pkc-%C3%AE-modulating-protein-dynamics
#16
Lena Reimann, Heike Wiese, Yvonne Leber, Anja N Schwäble, Anna L Fricke, Anne Rohland, Bettina Knapp, Christian D Peikert, Friedel Drepper, Peter F M van der Ven, Gerald Radziwill, Dieter O Fürst, Bettina Warscheid
The Z-disc is a protein-rich structure critically important for the development and integrity of myofibrils, which are the contractile organelles of cross-striated muscle cells. We here used mouse C2C12 myoblast which were differentiated into myotubes followed by electrical pulse stimulation (EPS) to generate contracting myotubes comprising mature Z-discs. Using a quantitative proteomics approach, we analyzed changes in the relative abundance of 2,588 proteins, of which 387 were significantly regulated in myoblasts versus myotubes...
December 27, 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28002607/targeting-of-mir-432-to-myozenin1-to-regulate-myoblast-proliferation-and-differentiation
#17
R M Ren, H Liu, S H Zhao, J H Cao
MicroRNAs (miRNAs) play important roles in the development and biochemical functions of skeletal muscles. However, targeting of miRNAs to structural genes involved in Z-discs have not been investigated. Here, we describe a highly expressed miRNA, miR-432, in pig embryonic skeletal muscle, which appeared to target myozenin1 (MYOZ1), a protein involved in the muscular sarcomere microstructure. Our results showed that miR-432 is involved in muscle development in the developing pig. In addition, it promoted differentiation of the C2C12 myoblast cell line into myotubes...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27943601/surgical-repair-of-annulus-defect-with-biomimetic-multilamellar-nano-microfibrous-scaffold-in-a-porcine-model
#18
R Kang, H Li, Z Xi, S Ringgard, A Baatrup, K Rickers, M Sun, D Q S Le, M Wang, L Xie, Y Xie, M Chen, C Bünger
Annulus defect is associated with reherniation and disc degeneration after discectomy; currently there is no effective treatment that addresses this problem. The annulus is a hierarchical lamellar structure, where each lamella consists of aligned collagen fibers, which are parallel and tilted at 30° to the spinal axis. In this study, a biomimetic biodegradable scaffold consisting multi-lamella nano/microfibers, sharing nano-topography and micro-porosity similar to the native lamellar structure, was assessed in a porcine model, aided by sealing with fascia and medical glue and subsequent suture fixation...
December 11, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27916038/-mid-to-long-term-outcomes-of-cervical-disc-arthroplasty-for-symptomatic-cervical-disc-disease-a-meta-analysis
#19
S L Kan, B Yang, G Z Ning, S J Gao, J C Sun, S Q Feng
Objective: To compare the benefits and harms of cervical disc arthroplasty (CDA) with anterior cervical discectomy and fusion(ACDF) for symptomatic cervical disc disease at mid- to long-term follow-up. Methods: Electronic searches were made in PubMed, EMBASE, and the Cochrane Library for randomized controlled trials with at least 48 moths follow-up.Outcomes were reported as relative risk or standardized mean difference.Meta-analysis was carried out using Revman version 5.3 and Stata version 12.0. Results: Seven trials were included, involving 2 302 participants...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27913258/an-experimental-study-on-the-effects-of-smoking-in-the-perinatal-period-and-during-lactation-on-the-intervertebral-disks-of-newborns
#20
Idiris Altun, Kasım Z Yuksel
OBJECTIVE: To evaluate the histopathologic effects of smoking before, during, and after pregnancy on the intervertebral disk structure of newborns in an experimental rat model. METHODS: Seven adult female Wistar albino rats were randomly allocated into 7 groups. Nicotine (2 mg/kg/d) was intraperitoneally introduced to these rats in 6 groups before, during, and after pregnancy, whereas the rat in the control group received isotonic saline intraperitoneally. Fourteen newborns delivered by each rat were euthanized at the end of 9 weeks after being breastfed for 3 weeks after birth...
March 2017: World Neurosurgery
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