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https://www.readbyqxmd.com/read/28097935/finite-element-simulations-of-the-head-brain-responses-to-the-top-impacts-of-a-construction-helmet-effects-of-the-neck-and-body-mass
#1
John Z Wu, Christopher S Pan, Bryan M Wimer, Charles L Rosen
Traumatic brain injuries are among the most common severely disabling injuries in the United States. Construction helmets are considered essential personal protective equipment for reducing traumatic brain injury risks at work sites. In this study, we proposed a practical finite element modeling approach that would be suitable for engineers to optimize construction helmet design. The finite element model includes all essential anatomical structures of a human head (i.e. skin, scalp, skull, cerebrospinal fluid, brain, medulla, spinal cord, cervical vertebrae, and discs) and all major engineering components of a construction helmet (i...
January 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28072995/-the-effects-of-platelet-rich-fibrin-extract-on-mc3t3-e1-cells-cultured-on-the-titanium-discs
#2
X J Zhang, S Xu, W Y Meng, H J Xiao, K Dong, Z H Liu
Objective: To evaluate the effect of platelet-rich fibrin extract (PRFe) on the adhesion, proliferation and differentiation of MC3T3-E1 cells cultured on the titanium discs. Methods: Samples were divided into experimental group (P) and control group (D). Group P used the α-minimal essential medium (α-MEM) containing PRFe (0.5%), while group D used only the α-MEM. Cell adhesion and cytoskeleton were observed using scanning electron microscopy (SEM) and laser scanning confocal microscopy (LSCM). Methyl thiazolyl tetrazolium (MTT) assay to detect the number of the osteoblasts at 1, 3, 5, 7 d; the activity of alkaline phosphatase (ALP) to detect the differentiation of osteoblast at 1, 3, 5, 7 d; the level of osteogenetic biomarkers core-binding factorα1 (cbfα1) and osteocalcin (OCN) were quantified by quantitative real-time PCR (qRT-PCR) at 3 and 7 d...
January 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28028127/myofibrillar-z-discs-are-a-protein-phosphorylation-hot-spot-with-pkc-%C3%AE-modulating-protein-dynamics
#3
Lena Reimann, Heike Wiese, Yvonne Leber, Anja N Schwäble, Anna L Fricke, Anne Rohland, Bettina Knapp, Christian D Peikert, Friedel Drepper, Peter F M van der Ven, Gerald Radziwill, Dieter O Fürst, Bettina Warscheid
The Z-disc is a protein-rich structure critically important for the development and integrity of myofibrils, which are the contractile organelles of cross-striated muscle cells. We here used mouse C2C12 myoblast which were differentiated into myotubes followed by electrical pulse stimulation (EPS) to generate contracting myotubes comprising mature Z-discs. Using a quantitative proteomics approach, we analyzed changes in the relative abundance of 2,588 proteins, of which 387 were significantly regulated in myoblasts versus myotubes...
December 27, 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28002607/targeting-of-mir-432-to-myozenin1-to-regulate-myoblast-proliferation-and-differentiation
#4
R M Ren, H Liu, S H Zhao, J H Cao
MicroRNAs (miRNAs) play important roles in the development and biochemical functions of skeletal muscles. However, targeting of miRNAs to structural genes involved in Z-discs have not been investigated. Here, we describe a highly expressed miRNA, miR-432, in pig embryonic skeletal muscle, which appeared to target myozenin1 (MYOZ1), a protein involved in the muscular sarcomere microstructure. Our results showed that miR-432 is involved in muscle development in the developing pig. In addition, it promoted differentiation of the C2C12 myoblast cell line into myotubes...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27943601/surgical-repair-of-annulus-defect-with-biomimetic-multilamellar-nano-microfibrous-scaffold-in-a-porcine-model
#5
R Kang, H Li, Z Xi, S Ringgard, A Baatrup, K Rickers, M Sun, D Q S Le, M Wang, L Xie, Y Xie, M Chen, C Bünger
Annulus defect is associated with reherniation and disc degeneration after discectomy; currently there is no effective treatment that addresses this problem. The annulus is a hierarchical lamellar structure, where each lamella consists of aligned collagen fibers, which are parallel and tilted at 30° to the spinal axis. In this study, a biomimetic biodegradable scaffold consisting multi-lamella nano/microfibers, sharing nano-topography and micro-porosity similar to the native lamellar structure, was assessed in a porcine model, aided by sealing with fascia and medical glue and subsequent suture fixation...
December 11, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27916038/-mid-to-long-term-outcomes-of-cervical-disc-arthroplasty-for-symptomatic-cervical-disc-disease-a-meta-analysis
#6
S L Kan, B Yang, G Z Ning, S J Gao, J C Sun, S Q Feng
Objective: To compare the benefits and harms of cervical disc arthroplasty (CDA) with anterior cervical discectomy and fusion(ACDF) for symptomatic cervical disc disease at mid- to long-term follow-up. Methods: Electronic searches were made in PubMed, EMBASE, and the Cochrane Library for randomized controlled trials with at least 48 moths follow-up.Outcomes were reported as relative risk or standardized mean difference.Meta-analysis was carried out using Revman version 5.3 and Stata version 12.0. Results: Seven trials were included, involving 2 302 participants...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27913258/an-experimental-study-on-the-effects-of-smoking-in-the-perinatal-period-and-during-lactation-on-the-intervertebral-discs-of-newborns
#7
Idiris Altun, Kasım Z Yuksel
OBJECTIVE: To evaluate the histopathological effects of smoking before, during and after pregnancy on the intervertebral disc structure of the newborns in an experimental rat model. METHODS: Seven adult female Wistar Albino rats were randomly allocated into 7 groups. Nicotine (2 mg/kg/day) was intraperitoneally introduced to these rats in 6 groups before, during and after pregnancy, while the rat in the control group received isotonic saline intraperitoneally. Fourteen newborns delivered by each rat were sacrificed at the end of 9 weeks after being breastfed for 3 weeks after birth...
November 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27881552/cardiac-t-tubule-microanatomy-and-function
#8
REVIEW
TingTing Hong, Robin M Shaw
Unique to striated muscle cells, transverse tubules (t-tubules) are membrane organelles that consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and interconnected network. Mature t-tubule networks are found in mammalian ventricular cardiomyocytes, with the transverse components of t-tubules occurring near sarcomeric z-discs. Cardiac t-tubules contain membrane microdomains enriched with ion channels and signaling molecules. The microdomains serve as key signaling hubs in regulation of cardiomyocyte function...
January 2017: Physiological Reviews
https://www.readbyqxmd.com/read/27869806/preliminary-efficacy-of-a-brief-family-intervention-to-prevent-declining-quality-of-life-secondary-to-parental-bone-marrow-transplantation
#9
B L Fife, D M Von Ah, M L Spath, M T Weaver, Z Yang, T Stump, S Farag
The primary purpose of this research was to develop and evaluate the efficacy and feasibility of a brief, cost-effective family-focused intervention to promote adaptive coping and quality of life throughout a parent's bone marrow transplantation (BMT). Targeted outcomes were cohesion, decreased use of avoidance coping, open communication and effective management of emotional distress. Participants included an intervention group of 31 families and 29 families in a control group who received usual care. Each family included the BMT recipient, a partner/caregiver and children 10-18 years old...
November 21, 2016: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27833406/interobserver-and-test-retest-reproducibility-of-t1%C3%AF-and-t2-measurements-of-lumbar-intervertebral-discs-by-3t-magnetic-resonance-imaging
#10
Yeon Hwa Yoo, Choon-Sik Yoon, Na Lae Eun, Moon-Jung Hwang, Hanna Yoo, Robert D Peters, Tae-Sub Chung, Young Han Lee, Jin-Suck Suh, Sungjun Kim
OBJECTIVE: To investigate the interobserver and test-retest reproducibility of T1ρ and T2 measurements of lumbar intervertebral discs using 3T magnetic resonance imaging (MRI). MATERIALS AND METHODS: This study included a total of 51 volunteers (female, 26; male, 25; mean age, 54 ± 16.3 years) who underwent lumbar spine MRI with a 3.0 T scanner. Amongst these subjects, 40 underwent repeat T1ρ and T2 measurement acquisitions with identical image protocol. Two observers independently performed the region of interest measurements in the nuclei pulposi of the discs from L1-2 through L5-S1 levels...
November 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27783625/zasp52-a-core-z-disc-protein-in-drosophila-indirect-flight-muscles-interacts-with-%C3%AE-actinin-via-an-extended-pdz-domain
#11
Kuo An Liao, Nicanor González-Morales, Frieder Schöck
Z-discs are organizing centers that establish and maintain myofibril structure and function. Important Z-disc proteins are α-actinin, which cross-links actin thin filaments at the Z-disc and Zasp PDZ domain proteins, which directly interact with α-actinin. Here we investigate the biochemical and genetic nature of this interaction in more detail. Zasp52 is the major Drosophila Zasp PDZ domain protein, and is required for myofibril assembly and maintenance. We show by in vitro biochemistry that the PDZ domain plus a C-terminal extension is the only area of Zasp52 involved in the interaction with α-actinin...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27759384/zoanthamine-type-alkaloids-from-the-zoanthid-zoanthus-kuroshio-collected-in-taiwan-and-their-effects-on-inflammation
#12
Yu-Ming Hsu, Fang-Rong Chang, I-Wen Lo, Kuei-Hung Lai, Mohamed El-Shazly, Tung-Ying Wu, Ying-Chi Du, Tsong-Long Hwang, Yuan-Bin Cheng, Yang-Chang Wu
Zoanthus kuroshio is a colorful zoanthid with a fluorescent pink oral disc and brown tentacles, which dominates certain parts of the Taiwanese and Japanese coasts. This sea anemone is a rich source of biologically active alkaloids. In the current investigation, two novel halogenated zoanthamines [5α-iodozoanthenamine (1) and 11β-chloro-11-deoxykuroshine A (2)], along with four new zoanthamines [18-epi-kuroshine A (3), 7α-hydroxykuroshine E (4), 5α-methoxykuroshine E (5), and 18-epi-kuroshine E (6)], and six known compounds were isolated from Z...
October 19, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27748905/resveratrol-analogue-e-8-acetoxy-2-2-3-4-diacetoxyphenyl-ethenyl-quinazoline-induces-apoptosis-via-fas-mediated-pathway-in-hl-60-human-leukemia-cells
#13
Eun Young Park, Joo-Il Kim, Dong-Gyu Leem, Ji-Sun Shin, Kyung-Tack Kim, Sang Yoon Choi, Myung-Hee Lee, Jung-Hye Choi, Yong Sup Lee, Kyung-Tae Lee
Previously, we reported that (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline (8-ADEQ), a synthetic analogue of resveratrol had anti-inflammatory and G2/M cell cycle arrest activities, but the underlying molecular mechanism of cytotoxic effects of this compound was not determined. In this study, 8-ADEQ displayed potent cytotoxicity and triggered apoptosis in HL-60 cells as evidenced by DNA fragmentation, DNA ladder formation, and the externalization of Annexin V-targeted phosphatidylserine residues in HL-60 cells...
December 2016: Oncology Reports
https://www.readbyqxmd.com/read/27747233/bonding-of-metal-orthodontic-attachments-to-sandblasted-porcelain-and-zirconia-surfaces
#14
Amitoj S Mehta, Carla A Evans, Grace Viana, Ana Bedran-Russo, Maria Therese S Galang-Boquiren
This study evaluates tensile bond strength (TBS) of metal orthodontic attachments to sandblasted feldspathic porcelain and zirconia with various bonding protocols. Thirty-six (36) feldspathic and 36 zirconia disc samples were prepared, glazed, embedded in acrylic blocks and sandblasted, and divided into three groups according to one or more of the following treatments: hydrofluoric acid 4% (HF), Porcelain Conditioner silane primer, Reliance Assure® primer, Reliance Assure plus® primer, and Z Prime™ plus zirconia primer...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27739023/bacteriological-assessment-of-pneumonia-caused-by-gram-negative-bacteria-in-patients-hospitalized-in-intensive-care-unit
#15
A Guzek, Krzysztof Korzeniewski, D Tomaszewski, Z Rybicki, E Zwolińska
The article presents the results of 11-year study (2005-2015) of Gram-negative bacteria responsible for pneumonia in 2033 mechanically ventilated patients hospitalized in Intensive Care Unit. Of 8796 biological samples, consisting mainly of bronchial aspirate (97.9 %), 2056 bacterial strains were isolated and subjected to identification. VITEK 2 was used to determine drug susceptibility (classified according to the EUCAST criteria). ESBL, MBL and KPC-producing strains were identified by means of phenotypic methods using appropriate discs...
October 14, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27722852/depletion-of-kindlin-2-induces-cardiac-dysfunction-in-mice
#16
Lihua Qi, Yu Yu, Xiaochun Chi, Danyu Lu, Yao Song, Youyi Zhang, Hongquan Zhang
Kindlin-2, a member of the Kindlin family focal adhesion proteins, plays an important role in cardiac development. It is known that defects in the Z-disc proteins lead to hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM). Our previous investigation showed that Kindlin-2 is mainly localized at the Z-disc and depletion of Kindlin-2 disrupts the structure of the Z-Disc. Here, we reported that depletion of Kindlin-2 leads to the disordered myocardial fibers, fractured and vacuolar degeneration in myocardial fibers...
September 20, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27706715/effects-of-mmp-1-and-mmp-3-gene-polymorphisms-on-gene-expression-and-protein-level-in-lumbar-disc-herniation
#17
B Eser, O Eser, Y Yuksel, H Aksit, E Karavelioglu, M Tosun, Z Sekerci
The aim of this study was to identify the possible correlation between polymorphisms in matrix metalloproteinase (MMP)-1 and MMP-3 and their corresponding protein levels in disc tissues obtained from patients with lumbar disc herniation (LDH) using biochemical and immunohistochemical analyses. Blood and disc samples were obtained from 100 patients with LDH who underwent a lumbar microdiscectomy. Based on the radiological degeneration, the patients were diagnosed with grade 2, 3, or 4 LDH. MMP-1 -1607 1G/2G and MMP-3 -1171 5A/6A were analyzed by real-time polymerase chain reaction...
September 9, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27693477/cervical-disc-arthroplasty-for-symptomatic-cervical-disc-disease-traditional-and-bayesian-meta-analysis-with-trial-sequential-analysis
#18
REVIEW
Shun-Li Kan, Zhi-Fang Yuan, Guang-Zhi Ning, Fei-Fei Liu, Jing-Cheng Sun, Shi-Qing Feng
OBJECTIVE: Cervical disc arthroplasty (CDA) has been designed as a substitute for anterior cervical discectomy and fusion (ACDF) in the treatment of symptomatic cervical disc disease (CDD). Several researchers have compared CDA with ACDF for the treatment of symptomatic CDD; however, the findings of these studies are inconclusive. Using recently published evidence, this meta-analysis was conducted to further verify the benefits and harms of using CDA for treatment of symptomatic CDD. METHODS: Relevant trials were identified by searching the PubMed, EMBASE, and Cochrane Library databases...
November 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27683199/a-novel-colonial-ciliate-zoothamnium-ignavum-sp-nov-ciliophora-oligohymenophorea-and-its-ectosymbiont-candidatus-navis-piranensis-gen-nov-sp-nov-from-shallow-water-wood-falls
#19
Lukas Schuster, Monika Bright
Symbioses between ciliate hosts and prokaryote or unicellular eukaryote symbionts are widespread. Here, we report on a novel ciliate species within the genus Zoothamnium Bory de St. Vincent, 1824, isolated from shallow-water sunken wood in the North Adriatic Sea (Mediterranean Sea), proposed as Zoothamnium ignavum sp. nov. We found this ciliate species to be associated with a novel genus of bacteria, here proposed as "Candidatus Navis piranensis" gen. nov., sp. nov. The descriptions of host and symbiont species are based on morphological and ultrastructural studies, the SSU rRNA sequences, and in situ hybridization with symbiont-specific probes...
2016: PloS One
https://www.readbyqxmd.com/read/27647249/-comparison-of-the-anterior-corneal-asphericity-after-small-incision-lenticule-extraction-and-femtosecond-laser-in-situ-keratomileusis
#20
X L Su, Y Wang, W J Wu, Z Q Wu, Y N Wu, C J Yu
Objective: To evaluate and compare the anterior corneal asphericity after small incision lenticule extraction(SMILE)and femtosecond laser in situ keratomileusis(FS-LASIK). Methods: In this case-control study, 45 subjects who underwent SMILE operation comprised the study group, and 33 subjects with FS-LASIK operation comprised the control group. The asphericity coefficient Q-value of the right eyes in both groups was measured at diameters of 6, 7, 8 and 9 mm, respectively, before surgery and at 1 day, 1 week, 1 month and 6 months following surgery...
September 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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