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https://www.readbyqxmd.com/read/29348471/three-dimensional-evaluation-of-posterior-pole-and-optic-nerve-head-in-tilted-disc
#1
Yong Chan Kim, Ji-Sun Moon, Hae-Young Lopilly Park, Chan Kee Park
For over a century, tilted disc syndrome (TDS) has been defined vaguely. The lack of consensus of the terminology arises from the lack of understanding of the pathogenesis of this condition. Also, myopic discs with temporal crescents or peripapillary atrophy (PPA) are histologically indistinguishable from TDS. Therefore, we examined the morphological background of the extreme ONH appearances such as the myopic tilted disc and the TDS by analyzing the posterior segment of the eye from a three-dimensional (3D) perspective...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29344379/changes-in-contractile-protein-expression-are-linked-to-ventricular-stiffness-in-infants-with-pulmonary-hypertension-or-right-ventricular-hypertrophy-due-to-congenital-heart-disease
#2
Andrew R Bond, Dominga Iacobazzi, Safa Abdul-Ghani, Mohammed Ghorbel, Kate Heesom, Mariangela Wilson, Christopher Gillett, Sarah J George, Massimo Caputo, Saadeh Suleiman, Robert M R Tulloh
Background: The right ventricle (RV) is not designed to sustain high pressure leading to failure. There are no current medications to help RV contraction, so further information is required on adaption of the RV to such hypertension. Methods: The Right Ventricle in Children (RVENCH) study assessed infants with congenital heart disease undergoing cardiac surgery with hypertensive RV. Clinical and echocardiographic data were recorded, and samples of RV were taken from matched infants, analysed for proteomics and compared between pathologies and with clinical and echocardiographic outcome data...
2018: Open Heart
https://www.readbyqxmd.com/read/29344073/bilateral-non-arteritic-anterior-ischaemic-optic-neuropathy-as-the-presentation-of-systemic-amyloidosis
#3
M Z Kanaan, A R Lorenzi, N Thampy, R Pandit, Margaret Dayan
A 75-year-old hypertensive female with stable idiopathic intermediate uveitis presented with bilateral sequential optic neuropathy with optic disc swelling. The optic neuropathy in the first affected eye (right) was thought to be due to non-arteritic anterior ischaemic optic neuropathy (NAION). Asymptomatic left optic disc swelling was found at routine review 2 months later, and a diagnosis of giant cell arteritis (GCA) was sought. Temporal artery duplex ultrasound showed the "halo sign," but a subsequent temporal artery biopsy showed light-chain (AL) amyloidosis with no signs of giant cell arteritis...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29310879/fracture-analysis-of-cad-cam-high-density-polymers-used-for-interim-implant-supported-fixed-cantilevered-prostheses
#4
Burak Yilmaz, Gülce Alp, Jeremy Seidt, William M Johnston, Roger Vitter, Edwin A McGlumphy
STATEMENT OF PROBLEM: The load-to-fracture performance of computer-assisted design and computer-assisted manufacturing (CAD-CAM) high-density polymer (HDP) materials in cantilevers is unknown. PURPOSE: The purposes of this in vitro study were to evaluate the load-to-fracture performance of CAD-CAM-fabricated HDPs and to compare that with performance of autopolymerized and injection-molded acrylic resins. MATERIAL AND METHODS: Specimens from 8 different brands of CAD-CAM HDPs, including Brylic Solid (BS); Brylic Gradient (BG); AnaxCAD Temp EZ (AE); AnaxCAD Temp Plus (AP); Zirkonzahn Temp Basic (Z); GDS Tempo-CAD (GD); Polident (Po); Merz M-PM-Disc (MAT); an autopolymerized acrylic resin, Imident (Conv) and an injection-molded acrylic resin, SR-IvoBase High Impact (Inj) were evaluated for load-to-fracture analysis (n=5)...
January 5, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29275262/design-synthesis-antibacterial-evaluation-and-molecular-docking-studies-of-some-new-quinoxaline-derivatives-targeting-dihyropteroate-synthase-enzyme
#5
Maryam A Z El-Attar, Rasha Y Elbayaa, Omaima G Shaaban, Nargues S Habib, Abeer E Abdel Wahab, Ibrahim A Abdelwahab, Soad A M El-Hawash
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) were designed and synthesized. The newly synthesized compounds were evaluated for their in vitro antibacterial activity against nine bacterial human pathogenic strains using the disc diffusion assay. In general, most of the synthesized compounds exhibited good antibacterial activities...
December 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29241769/antibacterial-activity-of-artemisia-asiatica-essential-oil-against-some-common-respiratory-infection-causing-bacterial-strains-and-its-mechanism-of-action-in-haemophilus-influenzae
#6
Chao Xu, Guo-Yan Li, Hua Zhang, Yu-Na Zu, Zhen-Hua Li, Jian-Li Chen
The main objective of the current study was to investigate the chemical composition of the essential oil of Artemisia asiatica together with investigating the antibacterial effects it exerts on several common respiratory infection causing bacteria including Haemophilus influenzae. Its mechanism of action was studied using various state-of-the-art assays like scanning electron microscopy, DNA, RNA and protein leakage assays, growth curve assays etc. The essential oil was extracted from the leaves of A. asiatica by supercritical CO2 fluid extraction technology...
December 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29222390/sodium-channel-remodeling-in-subcellular-microdomains-of-murine-failing-cardiomyocytes
#7
Mathilde R Rivaud, Esperanza Agullo-Pascual, Xianming Lin, Alejandra Leo-Macias, Mingliang Zhang, Eli Rothenberg, Connie R Bezzina, Mario Delmar, Carol Ann Remme
BACKGROUND: Cardiac sodium channel (NaV1.5) dysfunction contributes to arrhythmogenesis during pathophysiological conditions. Nav1.5 localizes to distinct subcellular microdomains within the cardiomyocyte, where it associates with region-specific proteins, yielding complexes whose function is location specific. We herein investigated sodium channel remodeling within distinct cardiomyocyte microdomains during heart failure. METHODS AND RESULTS: Mice were subjected to 6 weeks of transverse aortic constriction (TAC; n=32) to induce heart failure...
December 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29206857/z-disc-protein-chapb-induces-cardiomyopathy-and-contractile-dysfunction-in-the-postnatal-heart
#8
Willemijn van Eldik, Brigit den Adel, Jantine Monshouwer-Kloots, Daniela Salvatori, Saskia Maas, Ingeborg van der Made, Esther E Creemers, Derk Frank, Norbert Frey, Nicky Boontje, Jolanda van der Velden, Paul Steendijk, Christine Mummery, Robert Passier, Abdelaziz Beqqali
AIMS: The Z-disc is a crucial structure of the sarcomere and is implicated in mechanosensation/transduction. Dysregulation of Z-disc proteins often result in cardiomyopathy. We have previously shown that the Z-disc protein Cytoskeletal Heart-enriched Actin-associated Protein (CHAP) is essential for cardiac and skeletal muscle development. Furthermore, the CHAP gene has been associated with atrial fibrillation in humans. Here, we studied the misregulated expression of CHAP isoforms in heart disease...
2017: PloS One
https://www.readbyqxmd.com/read/29144007/analysis-of-surface-roughness-fracture-toughness-and-weibull-characteristics-of-different-framework-veneer-dental-ceramic-assemblies-after-grinding-polishing-and-glazing
#9
Guillermo Pradíes, Laura Godoy-Ruiz, Mutlu Özcan, Isabel Moreno-Hay, Francisco Martínez-Rus
PURPOSE: To compare the surface roughness and biaxial flexural strength of dental ceramics obtained after chairside surface modification by mechanical polishing procedures, versus laboratory reglazing. MATERIALS AND METHODS: Discs (16 × 1.5 ± 1.6 mm) (N = 90) of various framework-veneering combinations were fabricated: D/FC: lithium disilicate/feldspathic ceramic; Z/AL: zirconium dioxide/aluminous ceramic; N/FC: noble alloy/feldspathic ceramic; N/FF: noble alloy feldspathic with fluorapatite; B/FC: base alloy/feldspathic ceramic; B/FF: base alloy/feldspathic ceramic with fluorapatite...
November 16, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29106900/peripapillary-distribution-of-muller-cells-within-the-retinal-nerve-fiber-layer-in-human-eyes
#10
Shahar Frenkel, Gal Goshen, Lu Leach, Jacob Pe'er, Michael Mimouni, Eytan Z Blumenthal
The purpose of this study was to describe the distribution of Muller cell within the peripapillary retinal nerve fiber layer (RNFL) in human eyes. Eleven unpaired normal postmortem eyes were recruited into this study. Each eye was sectioned using the "umbrella technique" to obtain a concentric peripapillary ring centered on the optic disc, with a diameter of 3.0 mm. Immunohistochemistry with anti- CRALBP stained Muller cell within each ring. The RNFL thickness measurements around the peripapillary ring were: 262...
October 26, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29103396/prevalence-risk-factors-and-antimicrobial-resistance-of-salmonella-diarrhoeal-infection-among-children-in-thi-qar-governorate-iraq
#11
A Harb, M O'Dea, Z K Hanan, S Abraham, I Habib
We conducted a hospital-based cross-sectional study among children aged <5 years in Thi-Qar Governorate, south-eastern Iraq, in order to examine the prevalence, risk factors and antimicrobial resistance associated with gastroenteritis caused by Salmonella infection. From 320 diarrhoea cases enrolled between March and August 2016, 33 (10·3%, 95% confidence interval (CI) 8·4-12·4) cases were stool culture-positive for non-typhoidal Salmonella enterica. The most commonly identified serovar was Typhimurium (54%)...
November 6, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29090643/identification-through-maldi-tof-mass-spectrometry-and-antimicrobial-susceptibility-profiling-of-bacterial-pathogens-isolated-from-sow-urinary-tract-infection
#12
Luisa Z Moreno, Carlos E C Matajira, Andre P Poor, Renan E Mesquita, Vasco T M Gomes, Ana Paula S Silva, Cristina R Amigo, Ana Paula G Christ, Mikaela R F Barbosa, Maria Inês Z Sato, Andrea M Moreno
BACKGROUND: Urinary tract infection (UTI) is a common disease in sows due to intensification of pig production. Despite direct economic losses, UTI prevalence and respective microbial identification are still poorly studied. OBJECTIVE: The aims of this study were to identify the causative agents of UTI in sows through MALDI-TOF mass spectrometry and to characterize their respective antimicrobial resistance profiles. MATERIALS AND METHODS: Urine samples from 300 sows of three swine herds from São Paulo State (Brazil) were screened for UTI; suggestive samples were submitted to bacterial isolation...
November 1, 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/29066382/anti-staphylococcal-properties-of-eichhornia-crassipes-pistacia-vera-and-ziziphus-amole-leaf-extracts-isolates-from-cattle-and-rabbits
#13
Andrea Gutiérrez-Morales, Valente Velázquez-Ordoñez, Ameer Khusro, Abdelfattah Z M Salem, María Elena Estrada-Zúñiga, Mohamed Z M Salem, Benjamin Valladares-Carranza, Cristina Burrola-Aguilar
The desideratum aim of the present context was to assess the biopotency of methanolic extracts of Eichhornia crassipes (E. crassipes), Pistacia vera (P. vera), and Ziziphus amole (Z. amole) leaves against various staphylococcal strains, and to quantify the phenolics as well as saponin content in them. The antibacterial activity of various concentrations (62.5-1000 μg/mL) of plant extracts was tested against control clinical strains (Staphylococcus aureus ATCC 25923, S. aureus ATCC 29213, and S. aureus ATCC 43300), methicillin-resistant S...
October 21, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29050193/-the-vessel-and-primary-glaucoma
#14
R S Li, Y Z Pan
Glaucoma, as the first leading cause of irreversible blindness in the world, is a chronic progressive optic neuropathy. The pathogenesis of glaucoma is still not fully understood till now. A lot of studies about vascular diameter, tortuosity, location, disc perfusion, vascular regulation and systemic vascular factors had been conducted to investigate the relationship between the vascular states and glaucoma since vascular hypothesis proposed. However, direct and convincing evidence for primary mechanisms of glaucoma is still lacking...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29046390/novel-sarcopenia-related-alterations-in-sarcomeric-protein-post-translational-modifications-in-skeletal-muscles-identified-by-top-down-proteomics
#15
Liming Wei, Zachery R Gregorich, Ziqing Lin, Wenxuan Cai, Yutong Jin, Susan H McKiernan, Sean McIlwain, Judd M Aiken, Richard L Moss, Gary M Diffee, Ying Ge
Sarcopenia, the age-related loss of skeletal muscle mass and strength, is a significant cause of morbidity in the elderly and is a major burden on health care systems. Unfortunately, the underlying molecular mechanisms in sarcopenia remain poorly understood. Herein, we utilized top-down proteomics to elucidate sarcopenia-related changes in the fast- and slow-twitch skeletal muscles of aging rats with a focus on the sarcomeric proteome, which includes both myofilament and Z-disc proteins-the proteins that constitute the contractile apparatuses...
October 18, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29023169/associations-of-physical-activity-and-sedentary-behaviour-with-vision-threatening-diabetic-retinopathy-in-indonesian-population-with-type-2-diabetes-mellitus-jogjakarta-eye-diabetic-study-in-the-community-joged-com
#16
D P Dharmastuti, A N Agni, F Widyaputri, S Pawiroranu, Z M Sofro, F S Wardhana, S Haryanto, T W Widayanti, S Kotha, P Gupta, M B Sasongko
PURPOSE: To investigate the association of physical activity (PA) and sedentary behaviour with diabetic retinopathy (DR) in type 2 diabetes adults. METHODS: A community-based cross-sectional study of adults with type 2 diabetes. DR was assessed from disc- and macula-centred fundus photograph, and categorised into mild, moderate non-proliferative DR (NPDR), and Vision-Threatening DR (VTDR). Worse eye was used to determine the person's DR severity. PA was assessed using WHO Global Physical Activity Questionnaire (GPAQ)...
October 12, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28962912/a-minimum-of-5-year-follow-up-after-lumbar-transforaminal-epidural-steroid-injections-in-patients-with-lumbar-radicular-pain-due-to-intervertebral-disc-herniation
#17
David J Kennedy, Patricia Z Zheng, Matthew Smuck, Zachary L McCormick, Lisa Huynh, Byron J Schneider
BACKGROUND CONTEXT: Patients with lumbosacral radiculopathy from an intervertebral disc herniation are frequently treated by transforaminal epidural steroid injections (TFESIs). The long-term outcomes of these patients are poorly described. PURPOSE: We aimed to determine the long-term outcomes for a homogenous group of patients with acute unilateral lumbar radicular pain due to single-level herniated nucleus after lumbar epidural steroid injection at ≥5 years...
January 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28954028/optical-coherence-tomography-angiography-artifactual-choroidal-neovascularization-in-optic-disc-pit-maculopathy
#18
Marina Roizenblatt, Leo Muller, Claudio Z Lobos, Vinicius S Saraiva, Octaviano Magalhães, Andre Maia
This case report describes a 19-year-old Caucasian man presented with decreased visual acuity in the right eye for 3 months. Dilated funds exam revealed optic disk pit associated with serous macular detachment. Optical coherence tomography identified communication between the optic disk pit and the macular serous detachment, and optical coherence tomography angiography displayed a subfoveal area suggestive of subfoveal choroidal neovascularization. However, there was no evidence of leakage in the fluorescein angiogram and no evidence of choroidal neovascularization in optical coherence tomography in the area corresponding to the suspicious subfoveal choroidal neovascularization...
July 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28928759/identification-of-biomarkers-for-defense-response-to-plasmopara-viticola-in-a-resistant-grape-variety
#19
Giulia Chitarrini, Evelyn Soini, Samantha Riccadonna, Pietro Franceschi, Luca Zulini, Domenico Masuero, Antonella Vecchione, Marco Stefanini, Gabriele Di Gaspero, Fulvio Mattivi, Urska Vrhovsek
Downy mildew (Plasmopara viticola) is one of the most destructive diseases of the cultivated species Vitis vinifera. The use of resistant varieties, originally derived from backcrosses of North American Vitis spp., is a promising solution to reduce disease damage in the vineyards. To shed light on the type and the timing of pathogen-triggered resistance, this work aimed at discovering biomarkers for the defense response in the resistant variety Bianca, using leaf discs after inoculation with a suspension of P...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28884717/-clinical-and-emotional-behavioral-characteristics-of-acute-and-chronic-low-back-pain
#20
E Z Yakupov, T S Grigoryeva
AIM: To analyze clinical and emotional/behavioral characteristics of acute and chronic low-back pain that significantly affect quality-of-life. MATERIAL AND METHODS: Fifty-three patients with pain syndromes were examined using the painDETECT questionnaire, the Visual Analog Scale for Pain, The McGill Pain Questionnaire and laboratory and instrumental methods of neurological assessment. RESULTS AND CONCLUSION: A 'picture of the patient with acute and chronic pain' was built, a group of patients with neuropathic component of pain was described...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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