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Z disc

Yu-Ming Hsu, Fang-Rong Chang, I-Wen Lo, Kuei-Hung Lai, Mohamed El-Shazly, Tung-Ying Wu, Ying-Chi Du, Tsong-Long Hwang, Yuan-Bin Cheng, Yang-Chang Wu
Zoanthus kuroshio is a colorful zoanthid with a fluorescent pink oral disc and brown tentacles, which dominates certain parts of the Taiwanese and Japanese coasts. This sea anemone is a rich source of biologically active alkaloids. In the current investigation, two novel halogenated zoanthamines [5α-iodozoanthenamine (1) and 11β-chloro-11-deoxykuroshine A (2)], along with four new zoanthamines [18-epi-kuroshine A (3), 7α-hydroxykuroshine E (4), 5α-methoxykuroshine E (5), and 18-epi-kuroshine E (6)], and six known compounds were isolated from Z...
October 19, 2016: Journal of Natural Products
Eun Young Park, Joo-Il Kim, Dong-Gyu Leem, Ji-Sun Shin, Kyung-Tack Kim, Sang Yoon Choi, Myung-Hee Lee, Jung-Hye Choi, Yong Sup Lee, Kyung-Tae Lee
Previously, we reported that (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline (8-ADEQ), a synthetic analogue of resveratrol had anti-inflammatory and G2/M cell cycle arrest activities, but the underlying molecular mechanism of cytotoxic effects of this compound was not determined. In this study, 8-ADEQ displayed potent cytotoxicity and triggered apoptosis in HL-60 cells as evidenced by DNA fragmentation, DNA ladder formation, and the externalization of Annexin V-targeted phosphatidylserine residues in HL-60 cells...
October 13, 2016: Oncology Reports
Amitoj S Mehta, Carla A Evans, Grace Viana, Ana Bedran-Russo, Maria Therese S Galang-Boquiren
This study evaluates tensile bond strength (TBS) of metal orthodontic attachments to sandblasted feldspathic porcelain and zirconia with various bonding protocols. Thirty-six (36) feldspathic and 36 zirconia disc samples were prepared, glazed, embedded in acrylic blocks and sandblasted, and divided into three groups according to one or more of the following treatments: hydrofluoric acid 4% (HF), Porcelain Conditioner silane primer, Reliance Assure® primer, Reliance Assure plus® primer, and Z Prime™ plus zirconia primer...
2016: BioMed Research International
A Guzek, Krzysztof Korzeniewski, D Tomaszewski, Z Rybicki, E Zwolińska
The article presents the results of 11-year study (2005-2015) of Gram-negative bacteria responsible for pneumonia in 2033 mechanically ventilated patients hospitalized in Intensive Care Unit. Of 8796 biological samples, consisting mainly of bronchial aspirate (97.9 %), 2056 bacterial strains were isolated and subjected to identification. VITEK 2 was used to determine drug susceptibility (classified according to the EUCAST criteria). ESBL, MBL and KPC-producing strains were identified by means of phenotypic methods using appropriate discs...
October 14, 2016: Advances in Experimental Medicine and Biology
Lihua Qi, Yu Yu, Xiaochun Chi, Danyu Lu, Yao Song, Youyi Zhang, Hongquan Zhang
Kindlin-2, a member of the Kindlin family focal adhesion proteins, plays an important role in cardiac development. It is known that defects in the Z-disc proteins lead to hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM). Our previous investigation showed that Kindlin-2 is mainly localized at the Z-disc and depletion of Kindlin-2 disrupts the structure of the Z-Disc. Here, we reported that depletion of Kindlin-2 leads to the disordered myocardial fibers, fractured and vacuolar degeneration in myocardial fibers...
September 20, 2016: Science China. Life Sciences
B Eser, O Eser, Y Yuksel, H Aksit, E Karavelioglu, M Tosun, Z Sekerci
The aim of this study was to identify the possible correlation between polymorphisms in matrix metalloproteinase (MMP)-1 and MMP-3 and their corresponding protein levels in disc tissues obtained from patients with lumbar disc herniation (LDH) using biochemical and immunohistochemical analyses. Blood and disc samples were obtained from 100 patients with LDH who underwent a lumbar microdiscectomy. Based on the radiological degeneration, the patients were diagnosed with grade 2, 3, or 4 LDH. MMP-1 -1607 1G/2G and MMP-3 -1171 5A/6A were analyzed by real-time polymerase chain reaction...
September 9, 2016: Genetics and Molecular Research: GMR
Shun-Li Kan, Zhi-Fang Yuan, Guang-Zhi Ning, Fei-Fei Liu, Jing-Cheng Sun, Shi-Qing Feng
OBJECTIVE: Cervical disc arthroplasty (CDA) has been designed as a substitute for anterior cervical discectomy and fusion (ACDF) in the treatment of symptomatic cervical disc disease (CDD). Several researchers have compared CDA with ACDF for the treatment of symptomatic CDD; however, the findings of these studies are inconclusive. Using recently published evidence, this meta-analysis was conducted to further verify the benefits and harms of using CDA for treatment of symptomatic CDD. METHODS: Relevant trials were identified by searching the PubMed, EMBASE, and Cochrane Library databases...
October 2, 2016: International Journal of Surgery
Lukas Schuster, Monika Bright
Symbioses between ciliate hosts and prokaryote or unicellular eukaryote symbionts are widespread. Here, we report on a novel ciliate species within the genus Zoothamnium Bory de St. Vincent, 1824, isolated from shallow-water sunken wood in the North Adriatic Sea (Mediterranean Sea), proposed as Zoothamnium ignavum sp. nov. We found this ciliate species to be associated with a novel genus of bacteria, here proposed as "Candidatus Navis piranensis" gen. nov., sp. nov. The descriptions of host and symbiont species are based on morphological and ultrastructural studies, the SSU rRNA sequences, and in situ hybridization with symbiont-specific probes...
2016: PloS One
X L Su, Y Wang, W J Wu, Z Q Wu, Y N Wu, C J Yu
Objective: To evaluate and compare the anterior corneal asphericity after small incision lenticule extraction(SMILE)and femtosecond laser in situ keratomileusis(FS-LASIK). Methods: In this case-control study, 45 subjects who underwent SMILE operation comprised the study group, and 33 subjects with FS-LASIK operation comprised the control group. The asphericity coefficient Q-value of the right eyes in both groups was measured at diameters of 6, 7, 8 and 9 mm, respectively, before surgery and at 1 day, 1 week, 1 month and 6 months following surgery...
September 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Si-Dong Yang, Qian Chen, Sheng-Hua Ning, Wen-Yuan Ding, Da-Long Yang
BACKGROUND: Clinically, sclerosing thoracic disc herniation is a disease with high surgical risk and various complications. Eggshell procedure is a surgical method used by surgeons to treat sclerosing thoracic disc herniation. The aim of this study was to report a modified eggshell procedure to treat sclerosing thoracic disc herniation. METHODS: Medical records of 25 patients with sclerosing thoracic disc herniation were collected between 2007/01 and 2010/08, including 14 males and 11 females, with an average age of 51...
2016: Journal of Orthopaedic Surgery and Research
Mansour Znati, Insaf Filali, Aymen Jabrane, Joseph Casanova, Jalloul Bouajila, Hichem Ben Jannet
Essential oil of the seeds from the endemic Tunisian plant Ferula tunetana Pomel ex Batt. was analyzed for its chemical composition and screened for its antimicrobial, antioxidant and antigerminative properties. The chemical composition of the isolated oil is reported for the first time. According to the GC/FID, GC-MS and (13) C NMR analysis results; eighteen compounds were identified accounting for 84.6% of the total oil. The chemical composition of this essential oil was characterized by the presence of a high proportion of monoterpene hydrocarbons (77...
September 16, 2016: Chemistry & Biodiversity
J Palmio, B Udd
Distal myopathies and myofibrillar myopathies are both rare subcategories of muscle diseases. Myofibrillar myopathies are genetically heterogeneous group of diseases characterized by distinctive histopathology of abnormal protein aggregations and myofibrillar disintegration. All genes causing myofibrillar myopathy encode proteins that either reside in or associate with the Z-disc. Distal myopathies are also genetically heterogeneous muscular dystrophies in which muscle weakness presents distally in the feet and/or hands...
October 2016: Revue Neurologique
Z Miao, X-D Wang, L-X Mao, Y-H Xia, L-J Yuan, M Cai, J-Q Liu, B Wang, X Yang, L Zhu, H-B Yu, B Fang
The purpose of this study was to clarify the correlation between pre-treatment anterior disc displacement and mandibular stability after orthognathic and orthodontic treatment among patients with a skeletal class II malocclusion and without pre-treatment condylar resorption. Thirty-seven patients were included (7 male, 30 female). The mean length of follow-up was 6.76±3.06 years. Patients with condylar resorption before treatment were excluded. Magnetic resonance images and lateral cephalometric radiographs were taken before treatment (T0), after treatment (T1), and at follow-up (T2)...
September 13, 2016: International Journal of Oral and Maxillofacial Surgery
Iftikar Z Sutalaksana, Marisa Anatasia
BACKGROUND: Certain behavior types can drive the emergence of an unsafe act at the workplace which may be reflected by workers' perceptions toward safety climate. OBJECTIVE: The purpose of this study was to explore the relationship between workers' safety climate perceptions (NOSACQ-50 questionnaire) and their behavior types (based on DISC personality traits: Dominance, Influence, Steadiness, and Conscientiousness). METHODS: NOSACQ-50 and DISC assessment questionnaires were distributed on employees of four different companies (N = 755) working at hazardous workplaces in different occupational fields: fertilizer, coal mining, and oil & gas...
September 7, 2016: Work: a Journal of Prevention, Assessment, and Rehabilitation
Y-Z Cui, X-H Yang, P-F Liu, B Wang, W-J Chen
OBJECTIVE: The value of diagnosing lumbar disc degeneration with T1p magnetic resonance imaging (MRI), T2 mapping and diffusion-weighted imaging (DWI) technologies. PATIENTS AND METHODS: We selected 30 patients diagnosed with lumbar disc herniation (group A), 30 patients with lumbar disc degeneration (group B) and 30 healthy volunteers (group C) and carried out Pfirrmann grading of intervertebral discs (L1-S1 segment) based on conventional T2WI median sagittal images...
August 2016: European Review for Medical and Pharmacological Sciences
Z A Dzhumataeva
AIM: to evaluate the effectiveness of prolatan (latanoprost 0.005%) in the treatment of primary open-angle glaucoma (POAG). MATERIAL AND METHODS: The study included 35 POAG patients (41 eyes) aged 55-72 years, of them 20 men and 15 women. The patients were randomized into two groups followed up for 3 months. Group 1 consisted of 17 patients (19 eyes) who received prolatan once daily in the evening. Group 2 consisted of 18 patients (22 eyes) under Xalatan 0.005% once daily in the evening...
July 2016: Vestnik Oftalmologii
J Li, C Ma, Y M Li, Z H Wang, M Zhao, J Feng, W X Dai
OBJECTIVE: To compare the preliminary clinical outcomes of fenestration discectomy associated with annulus repair (FDAR) and fenestration discectomy (FD) for lumbar disc herniation in the adolescents. METHODS: The data of 26 adolescent patients with single segment lumbar disc herniation who were admitted to the Department of Orthopedics, Xuzhou Central Hospital from October 2012 to October 2014 were retrospectively studied. All patients were divided into 2 groups, including 12 patients undergoing FDAR and 14 patients undergoing FD respectively...
August 23, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
S M Sun, L Ding, H X Liu, X R Deng, C B Jing, R Z Zheng, Y F Wang
OBJECTIVE: To systematically evaluate the efficacy and safety of insulin degludec for diabetes mellitus (DM). METHODS: Databases including Cochrane Library, PubMed, Embase, Wanfang Data, China Biology Medicine disc (CBM) and China National Knowledge Infrastructure (CNKI) were searched electronically for randomized controlled trials (RCTs) meeting including criteria and the methodological quality of studies was assessed. Then meta-analysis was performed using RevMan 5...
August 23, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Thomas P Madaelil, Jeremiah R Long, Adam N Wallace, Jonathan C Baker, Wilson Z Ray, Paul Santiago, Jacob Buchowski, Lukas P Zebala, Jack W Jennings
STUDY DESIGN: Retrospective review. OBJECTIVE: Demonstrate proof-of-concept of preoperative percutaneous intraosseous fiducial marker placement prior to thoracic spine surgery. SUMMARY OF BACKGROUND DATA: Wrong level spine surgery is defined as a never event by Center for Medicare Services, yet the strength of data supporting the implementation of Universal Protocol to limit wrong level surgery is weak. The thoracic spine is especially prone to intraoperative mislocalization, particularly in cases of morbid obesity and anatomic variations...
August 31, 2016: Spine
Y P Li, K X Zhao, H Z Ma
OBJECTIVE: To investigate the effect and safety of the graduated "hang-back" recession of superior oblique (SO) in treatment of A-pattern strabismus with superior oblique overaction (SOOA). METHODS: Retrospective study. The clinical data of 15 cases (28 eyes), who underwent graduated "hang-back" recession of SO depending on the scales of SOOA, were collected and analyzed. The principle we carried on was hang-back recession 8-10mm for SOOA+4, 6 to 8 mm for SOOA+3, 5 to 6 mm for SOOA+2 and 4 mm for SOOA+1...
August 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
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