Tibor Kovács, Janka Szinyákovics, Viktor Billes, Gábor Murányi, Virginia B Varga, Annamária Bjelik, Ádám Légrádi, Melinda Szabó, Sára Sándor, Enikő Kubinyi, Cecília Szekeres-Paracky, Péter Szocsics, János Lőke, Jun Mulder, Balázs Gulyás, Éva Renner, Miklós Palkovits, Károly Gulya, Zsófia Maglóczky, Tibor Vellai
Ageing is driven by the progressive, lifelong accumulation of cellular damage. Autophagy (cellular self-eating) functions as a major cell clearance mechanism to degrade such damages, and its capacity declines with age. Despite its physiological and medical significance, it remains largely unknown why autophagy becomes incapable of effectively eliminating harmful cellular materials in many cells at advanced ages. Here we show that age-associated defects in autophagic degradation occur at both the early and late stages of the process...
December 17, 2022: Scientific Reports