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Oregon sudden unexpected death

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https://www.readbyqxmd.com/read/27895044/polymorphisms-in-the-gnas-gene-as-predictors-of-ventricular-tachyarrhythmias-and-sudden-cardiac-death-results-from-the-discovery-trial-and-oregon-sudden-unexpected-death-study
#1
Heinrich Wieneke, Jesper Hastrup Svendsen, Jeffrey Lande, Sebastian Spencker, Juan Gabriel Martinez, Bernhard Strohmer, Lauri Toivonen, Hervé Le Marec, F Javier Garcia-Fernandez, Domenico Corrado, Adriana Huertas-Vazquez, Audrey Uy-Evanado, Carmen Rusinaru, Kyndaron Reinier, Csaba Foldesi, Wieslaw Hulak, Sumeet S Chugh, Winfried Siffert
BACKGROUND: Population-based studies suggest that genetic factors contribute to sudden cardiac death (SCD). METHODS AND RESULTS: In the first part of the present study (Diagnostic Data Influence on Disease Management and Relation of Genetic Polymorphisms to Ventricular Tachy-arrhythmia in ICD Patients [DISCOVERY] trial) Cox regression was done to determine if 7 single-nucleotide polymorphisms (SNPs) in 3 genes coding G-protein subunits (GNB3, GNAQ, GNAS) were associated with ventricular tachyarrhythmia (VT) in 1145 patients receiving an implantable cardioverter-defibrillator (ICD)...
November 28, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27523774/tpeak-to-tend-interval-corrected-for-heart-rate-a-more-precise-measure-of-increased-sudden-death-risk
#2
Kelvin C M Chua, Carmen Rusinaru, Kyndaron Reinier, Audrey Uy-Evanado, Harpriya Chugh, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: The Tpeak to Tend (Tpe) interval on the 12-lead electrocardiogram predicts an increased risk of sudden cardiac arrest (SCA). There is controversy over whether Tpe would be more useful if corrected for heart rate (Tpec). OBJECTIVES: We evaluated whether the predictive value of Tpe for SCA improves with heart rate correction and sought to determine an optimal cutoff value for Tpec in the context of SCA risk. METHODS: Cases of SCA (n = 628; mean age 66...
November 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27256423/left-ventricular-geometry-and-risk-of-sudden-cardiac-arrest-in-patients-with-preserved-or-moderately-reduced-left-ventricular-ejection-fraction
#3
Aapo L Aro, Kyndaron Reinier, Derek Phan, Carmen Teodorescu, Audrey Uy-Evanado, Gregory A Nichols, Karen Gunson, Jonathan Jui, Sumeet S Chugh
AIMS: The majority of sudden cardiac arrests (SCAs) occur in patients with left-ventricular (LV) ejection fraction (LVEF) >35%, yet there are no methods for effective risk stratification in this sub-group. Since abnormalities of LV geometry can be identified even with preserved LVEF, we investigated the potential impact of LV geometry as a novel risk marker for this patient population. METHODS AND RESULTS: In the ongoing Oregon Sudden Unexpected Death Study, SCA cases with archived echocardiographic data available were prospectively identified during 2002-15, and compared with geographical controls...
June 2, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27094232/wide-qrs-t-angle-on-the-12-lead-ecg-as-a-predictor-of-sudden-death-beyond-the-lv-ejection-fraction
#4
Kelvin C M Chua, Carmen Teodorescu, Kyndaron Reinier, Audrey Uy-Evanado, Aapo L Aro, Sandeep G Nair, Harpriya Chugh, Jonathan Jui, Sumeet S Chugh
INTRODUCTION: Improvements in risk stratification for sudden cardiac arrest (SCA) will require discovery of markers that extend beyond the LV ejection fraction (LVEF). The frontal QRS-T angle has been shown to predict risk of SCA but the value of this marker independent of the LVEF has not been investigated. METHODS AND RESULTS: Cases of adult SCA with an archived electrocardiogram (12-lead ECG) available before the event, with a computable frontal QRS-T angle, were identified from the Oregon Sudden Unexpected Death Study (Oregon SUDS) ongoing in the Portland, Oregon metro area...
July 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27001038/cardiac-structural-and-functional-profile-of-patients-with-delayed-qrs-transition-zone-and-sudden-cardiac-death
#5
Aapo L Aro, Derek Phan, Carmen Teodorescu, Audrey Uy-Evanado, Kyndaron Reinier, Karen Gunson, Jonathan Jui, Heikki V Huikuri, Sumeet S Chugh
AIMS: Delayed QRS transition zone in the precordial leads of the 12-lead electrocardiogram (ECG) has been recently associated with increased risk of sudden cardiac death (SCD), but the underlying mechanisms are unknown. We correlated echocardiographic findings with ECG and clinical characteristics to investigate how alterations in cardiac structure and function contribute to this risk marker. METHODS AND RESULTS: From the ongoing population-based Oregon Sudden Unexpected Death Study (catchment population ∼1 million), SCD cases with prior ECG available (n = 627) were compared with controls (n = 801)...
March 21, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/26949741/electrocardiographic-markers-and-the-left-ventricular-ejection-fraction-have-cumulative-effects-on-risk-of-sudden-cardiac-death
#6
Kyndaron Reinier, Kumar Narayanan, Audrey Uy-Evanado, Carmen Teodorescu, Harpriya Chugh, Wendy J Mack, Karen Gunson, Jonathan Jui, Sumeet S Chugh
OBJECTIVES: To assess potential improvement in SCD risk prediction by adding selected risk markers from the 12-lead ECG to measurement of the left ventricular ejection fraction (LVEF). BACKGROUND: Novel strategies to improve risk stratification for sudden cardiac death (SCD) are needed. Given the modest odds associated with most individual risk markers, combining multiple markers may be a useful approach. METHODS: From the ongoing Oregon Sudden Unexpected Death Study, SCD cases with pre-event LVEF available were compared to matched control subjects with coronary artery disease...
December 1, 2015: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/26699237/delayed-intrinsicoid-deflection-of-the-qrs-complex-is-associated-with-sudden-cardiac-arrest
#7
Navid Darouian, Kumar Narayanan, Aapo L Aro, Kyndaron Reinier, Audrey Uy-Evanado, Carmen Teodorescu, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Prolongation of initial ventricular depolarization on the 12-lead electrocardiogram (ECG), or delayed intrinsicoid deflection (DID), can indicate left ventricular hypertrophy (LVH). The possibility that this marker could convey distinct risk of sudden cardiac arrest (SCA) has not been evaluated. OBJECTIVE: To evaluate the association of DID and SCA in the community. METHODS: In the ongoing prospective, population-based Oregon Sudden Unexpected Death Study (Oregon SUDS; catchment area approximately 1 million), SCA cases were compared to geographic controls with no SCA...
April 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/26685031/occupation-and-risk-of-sudden-death-in-a-united-states-community-a-case-control-analysis
#8
Lin Zhang, Kumar Narayanan, Vallabh Suryadevara, Carmen Teodorescu, Kyndaron Reinier, Audrey Uy-Evanado, Harpriya Chugh, Zhi-Jie Zheng, Karen Gunson, Jonathan Jui, Sumeet S Chugh
OBJECTIVE: Work environment is said to influence cardiovascular risk. We assessed whether nature of occupation affects risk of sudden cardiac death (SCD) in the general population. METHODS: In the ongoing, prospective Oregon Sudden Unexpected Death Study (catchment population 1 million), working-age SCD cases (18-65 years) were compared with controls who died from any cause. Usual occupation obtained from death certificates was classified using the US Census Bureau standard occupational classification descriptions and categorised as white collar, blue collar or homemaker...
2015: BMJ Open
https://www.readbyqxmd.com/read/26628059/t-wave-reversal-in-the-augmented-unipolar-right-arm-electrocardiographic-lead-is-associated-with-increased-risk-of-sudden-death
#9
Derek Phan, Kumar Narayanan, Audrey Uy-Evanado, Carmen Teodorescu, Kyndaron Reinier, Harpriya Chugh, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Repolarization abnormalities are associated with ventricular arrhythmias, and published studies report that a reversal of T wave polarity (positive or flat T wave) in lead aVR may be linked to increased cardiovascular mortality. We evaluated whether a positive or flat T wave in aVR is a risk marker for sudden cardiac death (SCD). METHODS: SCD cases from the Oregon Sudden Unexpected Death Study (catchment population ~1 million) were compared to geographic controls with coronary artery disease and no history of SCD...
March 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/26416619/mitral-valve-prolapse-and-sudden-cardiac-arrest-in-the-community
#10
Kumar Narayanan, Audrey Uy-Evanado, Carmen Teodorescu, Kyndaron Reinier, Gregory A Nichols, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Mitral valve prolapse (MVP) is relatively common in the general population with recently reported prevalence of 1% and familial clustering (Framingham Heart Study). However, its association with ventricular arrhythmias and sudden cardiac arrest (SCA) remains controversial. OBJECTIVES: The purpose of this study was to characterize the frequency and clinical profile of patients with MVP who suffer SCA in the community. METHODS: Patients with SCA cases were prospectively identified in the population-based Oregon Sudden Unexpected Death Study (population ~1 million)...
February 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/26240262/distinctive-clinical-profile-of-blacks-versus-whites-presenting-with-sudden-cardiac-arrest
#11
COMPARATIVE STUDY
Kyndaron Reinier, Gregory A Nichols, Adriana Huertas-Vazquez, Audrey Uy-Evanado, Carmen Teodorescu, Eric C Stecker, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Sudden cardiac arrest (SCA) is a major contributor to mortality, but data are limited among nonwhites. Identification of differences in clinical profile based on race may provide opportunities for improved SCA prevention. METHODS AND RESULTS: In the ongoing Oregon Sudden Unexpected Death Study (SUDS), individuals experiencing SCA in the Portland, OR, metropolitan area were identified prospectively. Patient demographics, arrest circumstances, and pre-SCA clinical profile were compared by race among cases from 2002 to 2012 (for clinical history, n=126 blacks, n=1262 whites)...
August 4, 2015: Circulation
https://www.readbyqxmd.com/read/26114160/cumulative-effects-of-common-genetic-variants-on-risk-of-sudden-cardiac-death
#12
Adriana Huertas-Vazquez, Christopher P Nelson, Janet S Sinsheimer, Kyndaron Reinier, Audrey Uy-Evanado, Carmen Teodorescu, Jo Ayala, Alistair S Hall, Karen Gunson, Jonathan Jui, Nilesh J Samani, Sumeet S Chugh
BACKGROUND: Genome-wide association studies and candidate-gene based approaches have identified multiple common variants associated with increased risk of sudden cardiac death (SCD). However, the independent contribution of these individual loci to disease risk is modest. OBJECTIVE: To investigate the cumulative effects of genetic variants previously associated with SCD risk. METHODS: A total of 966 SCD cases from the Oregon-Sudden Unexpected Death Study and 1,926 coronary artery disease controls from the Wellcome Trust Case-Control Consortium were investigated...
June 1, 2015: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/25762804/qrs-fragmentation-and-sudden-cardiac-death-in-the-obese-and-overweight
#13
Kumar Narayanan, Lin Zhang, Candice Kim, Audrey Uy-Evanado, Carmen Teodorescu, Kyndaron Reinier, Zhi-Jie Zheng, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Obesity has been associated with significantly greater risk of sudden cardiac death (SCD); however, identifying the obese patient at highest risk remains a challenge. We evaluated the association between QRS fragmentation on the 12-lead electrocardiogram and SCD, in obese/overweight subjects. METHODS AND RESULTS: In the ongoing prospective, community-based Oregon Sudden Unexpected Death Study (population approximately 1 million), we performed a case-control analysis, comparing obese/overweight SCD victims with obese/overweight controls from the same geographic region...
March 2015: Journal of the American Heart Association
https://www.readbyqxmd.com/read/25240696/sex-hormone-levels-in-patients-with-sudden-cardiac-arrest
#14
COMPARATIVE STUDY
Kumar Narayanan, Rasmus Havmoeller, Kyndaron Reinier, Katherine Jerger, Carmen Teodorescu, Audrey Uy-Evanado, Jo Navarro, Adriana Huertas-Vazquez, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Sex hormones are known to have significant effects on the pathophysiology of cardiovascular disease. OBJECTIVE: The purpose of this study was to study the association between sex hormone levels and sudden cardiac arrest (SCA). METHODS: In the ongoing Oregon Sudden Unexpected Death Study (catchment population approximately 1 million), cases of SCA were compared with matched controls. Testosterone and estradiol levels were measured from blood samples drawn at the time of the SCA event in cases and during a routine visit in controls...
December 2014: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/25227407/left-ventricular-diameter-and-risk-stratification-for-sudden-cardiac-death
#15
COMPARATIVE STUDY
Kumar Narayanan, Kyndaron Reinier, Carmen Teodorescu, Audrey Uy-Evanado, Ryan Aleong, Harpriya Chugh, Gregory A Nichols, Karen Gunson, Barry London, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Left ventricular (LV) diameter is routinely measured on the echocardiogram but has not been jointly evaluated with the ejection fraction (EF) for risk stratification of sudden cardiac death (SCD). METHODS AND RESULTS: From a large ongoing community-based study of SCD (The Oregon Sudden Unexpected Death Study; population ≈1 million), SCD cases were compared with geographic controls. LVEF and LV diameter, measured using the LV internal dimension in diastole (categorized as normal, mild, moderate, or severe dilatation using American Society of Echocardiography definitions) were assessed from echocardiograms prior but unrelated to the SCD event...
September 16, 2014: Journal of the American Heart Association
https://www.readbyqxmd.com/read/24952687/the-association-between-atrial-fibrillation-and-sudden-cardiac-death-the-relevance-of-heart-failure
#16
COMPARATIVE STUDY
Kyndaron Reinier, Eloi Marijon, Audrey Uy-Evanado, Carmen Teodorescu, Kumar Narayanan, Harpriya Chugh, Karen Gunson, Jonathan Jui, Sumeet S Chugh
OBJECTIVES: The purpose of this study was to evaluate the role of congestive heart failure (CHF) in the association between atrial fibrillation (AF) and sudden cardiac death (SCD). BACKGROUND: Recent studies have reported the possibility of an independent association between AF and SCD. We hypothesized that a history of CHF is a significant confounder of this association. METHODS: In a prospective case-control analysis from the community (The Oregon-SUDS [Sudden Unexpected Death Study], 2002 to 2012), SCD cases (n = 652) with clinical records available (including electrocardiography and/or echocardiography) were compared with age- and sex-matched control patients with coronary artery disease...
June 2014: JACC. Heart Failure
https://www.readbyqxmd.com/read/24657425/electrocardiographic-versus-echocardiographic-left-ventricular-hypertrophy-and-sudden-cardiac-arrest-in-the-community
#17
COMPARATIVE STUDY
Kumar Narayanan, Kyndaron Reinier, Carmen Teodorescu, Audrey Uy-Evanado, Harpriya Chugh, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Left ventricular hypertrophy (LVH) is associated with increased risk of sudden cardiac arrest (SCA). Whether LVH diagnosed by 12-lead ECG vs echocardiogram conveys identical or distinct risk information has not been previously evaluated. OBJECTIVE: The purpose of this study was to compare the association between ECG vs echocardiographic LVH and SCA in the community. METHODS: In a large, prospective population-based study (The Oregon Sudden Unexpected Death Study; population approximately 1 million), cases of SCA were compared to controls recruited from the same geographical area...
June 2014: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/24610738/public-health-burden-of-sudden-cardiac-death-in-the-united-states
#18
MULTICENTER STUDY
Eric C Stecker, Kyndaron Reinier, Eloi Marijon, Kumar Narayanan, Carmen Teodorescu, Audrey Uy-Evanado, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: Sudden cardiac death (SCD) is a leading cause of death in the United States, but the relative public health burden is unknown. We estimated the burden of premature death from SCD and compared it with other diseases. METHODS AND RESULTS: Analyses were based on the following data sources (using most recent sources that provided appropriately stratified data): (1) leading causes of death among men and women from 2009 US death certificate reporting; (2) individual cancer mortality rates from 2008 death certificate reporting from the Centers for Disease Control and Prevention's National Program of Cancer Registries; (3) county, state, and national population data for 2009 from the US Census Bureau; and (4) SCD rates from the Oregon Sudden Unexpected Death Study (SUDS) population-based surveillance study of SCD between 2002 and 2004...
April 2014: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/24418168/elevated-plasma-free-fatty-acids-are-associated-with-sudden-death-a-prospective-community-based-evaluation-at-the-time-of-cardiac-arrest
#19
Rasmus Havmoeller, Kyndaron Reinier, Carmen Teodorescu, Naser Ahmadi, Dorothy Kwok, Audrey Uy-Evanado, Yii-Der I Chen, Jerome I Rotter, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: In cohort studies, elevated levels of plasma nonesterified free fatty acids (NEFAs) have been associated with increased risk of sudden cardiac death (SCD) in men, but blood samples were drawn several years before SCD. OBJECTIVE: To confirm this relationship by evaluating levels of plasma NEFAs at the time of the SCD event in a group of both men and women. METHODS: From the ongoing Oregon Sudden Unexpected Death Study, we compared levels of plasma NEFAs in 149 SCD cases presenting with ventricular fibrillation (mean age 64 ± 12 years; 73% men) and 149 age- and sex-matched controls with coronary artery disease...
April 2014: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/24048201/frequency-and-determinants-of-implantable-cardioverter-defibrillator-deployment-among-primary-prevention-candidates-with-subsequent-sudden-cardiac-arrest-in-the-community
#20
Kumar Narayanan, Kyndaron Reinier, Audrey Uy-Evanado, Carmen Teodorescu, Harpriya Chugh, Eloi Marijon, Karen Gunson, Jonathan Jui, Sumeet S Chugh
BACKGROUND: The prevalence rates and influencing factors for deployment of primary prevention implantable cardioverter defibrillators (ICDs) among subjects who eventually experience sudden cardiac arrest in the general population have not been evaluated. METHODS AND RESULTS: Cases of adult sudden cardiac arrest with echocardiographic evaluation before the event were identified from the ongoing Oregon Sudden Unexpected Death Study (population approximately 1 million)...
October 15, 2013: Circulation
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