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https://www.readbyqxmd.com/read/28917219/reuma-pt-contribution-to-the-knowledge-of-immune-mediated-systemic-rheumatic-diseases
#1
Maria José Santos, Helena Canhão, Ana Filipa Mourão, Filipa Oliveira Ramos, Cristina Ponte, Cátia Duarte, Anabela Barcelos, Fernando Martins, José António Melo Gomes
Patient registries are key instruments aimed at a better understanding of the natural history of diseases, at assessing the effectiveness of therapeutic interventions, as well as identifying rare events or outcomes that are not captured in clinical trials. However, the potential of registries goes far beyond these aspects. For example, registries promote the standardization of clinical practice, can also provide information on domains that are not routinely collected in clinical practice and can support decision-making...
July 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28535544/portuguese-recommendations-for-the-use-of-biological-therapies-in-patients-with-rheumatoid-arthritis-2016-update
#2
Catia Duarte, Joana Sousa-Neves, Ana Águeda, Pedro Ribeiro, Alexandra Daniel, Gisela Eugénio, Sofia Serra, Filipe Araújo, Anabela Barcelos, Barcelos Filipe, Miguel Bernardes, Helena Canhão, Marcos Cerqueira, Susana Capela, Ana Cordeiro, Flavio Costa, Lucia Costa, Margarida Cruz, Luis Cunha Miranda, Catarina Duarte, Sandra Falcão, Daniela Faria, Ricardo Figueira, João Pedro Freitas, Maria João Gonçalves, João Madruga Dias, José Melo Gomes, Ana Filipa Mourão, Adriano Neto, Filipa Oliveira Ramos, Sofia Pimenta, Patricia Pinto, Joaquim Polido-Pereira, Cristina Ponte, João Ramos, Ana Rodrigues, Helena Santos, Maria José Santos, Alexandre Sepriano, Candida Silva, José Tavares Costa, Filipa Teixeira, Vitor Teixeira, Paula Valente, Elsa Vieira-Sousa, Rita Barros, Pedro Abreu, João Eurico Fonseca
OBJECTIVE: To update the recommendations for the treatment of Rheumatoid Arthritis (RA) with biological therapies, endorsed by the Portuguese Society of Rheumatology (SPR). METHODS: These treatment recommendations were formulated by Portuguese rheumatologists based on literature evidence and consensus opinion. At a national meeting the 10 recommendations were discussed and updated. The document resulting from this meeting circulated to all Portuguese rheumatologists, who anonymously voted online on the level of agreement with the recommendations...
June 1, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28457068/acquired-hemophilia-a-in-a-patient-with-non-small-cell-lung-carcinoma-a-rare-paraneoplastic-phenomenon
#3
Gal Ben Haim, Uri Manor, Sarit Appel, Shadan Lalezari, Reuma Margalit-Yehuda, Shmuel Steinlauf
No abstract text is available yet for this article.
February 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28371797/real-life-effectiveness-of-golimumab-in-biologic-na%C3%A3-ve-patients-with-rheumatoid-arthritis-data-from-the-rheumatic-diseases-portuguese-register-reuma-pt
#4
Ana Filipa Mourão, Célia Ribeiro, Joana Borges, Maria João Gonçalves, Miguel Bernardes, Susana Fernandes, Raquel Dezerto, Pedro Laires, Patrícia Machado, Mónica Eusébio, Maria José Santos, Helena Canhão
OBJECTIVES: To assess the effectiveness of subcutaneous Golimumab 50 mg/monthly combined with methotrexate (SC GLM + MTX) over 52 weeks of treatment, in biologic-naïve RA patients, in a multicentre nationwide cohort from the Rheumatic Diseases Portuguese Register (Reuma.pt). METHODS: Data for this observational study was collected from March 2011 to August 2015. Disease activity (DAS28), functional capacity (HAQ) and Patient Global Disease Assessment (PGDA) were measured at baseline and weeks 12, 24 and 52 of treatment...
June 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28299312/genetic-screening-of-mutations-associated-with-fabry-disease-in-a-nationwide-cohort-of-juvenile-idiopathic-arthritis-patients
#5
Maria J Gonçalves, Ana F Mourão, António Martinho, Olívia Simões, José Melo-Gomes, Manuel Salgado, Paula Estanqueiro, Célia Ribeiro, Iva Brito, João E Fonseca, Helena Canhão
Fabry's disease (FD) is a lysosomal storage disorder associated with an alpha-galactosidase A deficiency. The prevalence of FD among juvenile idiopathic arthritis (JIA) patients with established diagnosis is unknown, but as musculoskeletal pain may be an important complaint at presentation, misdiagnosed cases are anticipated. With this study, we aim to calculate the frequency of FD-associated mutations in a cohort of JIA patients. Children with JIA from a national cohort were selected. Clinical and laboratorial information was recorded in the Portuguese rheumatic diseases register (http://Reuma...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/27752356/juvenile-idiopathic-arthritis-in-adulthood-fulfilment-of-classification-criteria-for-adult-rheumatic-diseases-long-term-outcomes-and-predictors-of-inactive-disease-functional-status-and-damage
#6
Filipa Oliveira-Ramos, Mónica Eusébio, Fernando M Martins, Ana Filipa Mourão, Carolina Furtado, Raquel Campanilho-Marques, Inês Cordeiro, Joana Ferreira, Marcos Cerqueira, Ricardo Figueira, Iva Brito, Helena Canhão, Maria José Santos, José A Melo-Gomes, João Eurico Fonseca
OBJECTIVES: To determine how adult juvenile idiopathic arthritis (JIA) patients fulfil classification criteria for adult rheumatic diseases, evaluate their outcomes and determine clinical predictors of inactive disease, functional status and damage. METHODS: Patients with JIA registered on the Rheumatic Diseases Portuguese Register (Reuma.pt) older than 18 years and with more than 5 years of disease duration were included. Data regarding sociodemographic features, fulfilment of adult classification criteria, Health Assessment Questionnaire, Juvenile Arthritis Damage Index-articular (JADI-A) and Juvenile Arthritis Damage Index-extra-articular (JADI-E) damage index and disease activity were analysed...
2016: RMD Open
https://www.readbyqxmd.com/read/27750274/predictors-of-response-to-tnf-blockers-in-patients-with-polyarticular-psoriatic-arthritis
#7
Pedro David Carvalho, Cátia Duarte, Elsa Vieira-Sousa, Luís Cunha-Miranda, Pedro Avila-Ribeiro, Helena Santos, Miguel Bernardes, Maria José Santos, Marcos Cerqueira, Margarida Mateus, Patrícia Nero, Ana Águeda, José António Pereira da Silva, Pedro Machado
Psoriatic arthritis (PsA) is a chronic inflammatory rheumatic disease with a broad clinical spectrum. PsA can affect the axial skeleton, peripheral joints, entheses, synovial sheaths of tendons, skin, nails and extra-articular organs. Tumour necrosis factor alpha blockers (TNF blockers) were a breakthrough development in the treatment of PsA. Identifying predictors of response to biological therapies in patients with PsA is of utmost importance, especially in view of the costs and potential side effects of these agents...
January 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27559820/now-you-have-my-attention-empathic-accuracy-pathways-in-couples-and-the-role-of-conflict
#8
Haran Sened, Iftah Yovel, Eran Bar-Kalifa, Reuma Gadassi, Eshkol Rafaeli
Recent research on empathy finds evidence for 2 different pathways that enable individuals to accurately infer other persons' inner mental states: an automatic, indirect pathway that operates by having a mental state similar to the target's and (correctly) assuming that this state is similar to the target's, and a more controlled direct pathway that involves assessing the target's mental state with no regard for one's own. We present 3 daily diary studies (N = 53, 38 and 80 couples) examining the contribution of these pathways to empathic accuracy in daily assessments of romantic partners' negative moods, and examine the effects of gender and relational conflict on these pathways...
February 2017: Emotion
https://www.readbyqxmd.com/read/27441576/maternal-depression-and-anxiety-social-synchrony-and-infant-regulation-of-negative-and-positive-emotions
#9
Adi Granat, Reuma Gadassi, Eva Gilboa-Schechtman, Ruth Feldman
Maternal postpartum depression (PPD) exerts long-term negative effects on infants; yet the mechanisms by which PPD disrupts emotional development are not fully clear. Utilizing an extreme-case design, 971 women reported symptoms of depression and anxiety following childbirth and 215 high and low on depressive symptomatology reported again at 6 months. Of these, mothers diagnosed with major depressive disorder (n = 22), anxiety disorders (n = 19), and controls (n = 59) were visited at 9 months. Mother-infant interaction was microcoded for maternal and infant's social behavior and synchrony...
February 2017: Emotion
https://www.readbyqxmd.com/read/27273894/effect-of-comedication-with-conventional-synthetic-disease-modifying-antirheumatic-drugs-on-retention-of-tumor-necrosis-factor-inhibitors-in-patients-with-spondyloarthritis-a-prospective-cohort-study
#10
A Sepriano, S Ramiro, D van der Heijde, P Ávila-Ribeiro, R Fonseca, J Borges, L Teixeira, P D Carvalho, M Cerqueira, J Neves, T Meirinhos, A Barcelos, G Sequeira, M J Salvador, J Canas da Silva, H Santos, M Bernardes, E Vieira-Sousa, H Canhão, J C Branco, F Pimentel-Santos, R Landewé
OBJECTIVE: To evaluate whether use of comedication with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) influences the retention of tumor necrosis factor inhibitors (TNFi) in patients with spondyloarthritis (SpA). METHODS: Patients with SpA from the Rheumatic Diseases Portuguese Register who started treatment with their first TNFi between 2001 and 2014 were included in this study. Cox regression analysis was used to estimate the effect of comedication with csDMARDs on TNFi retention in 2 types of models: a model in which baseline (time-fixed) variables were included, and a second model incorporating time-varying variables, including sociodemographic features, measures of disease activity, measures of physical function, and cotreatment with other drugs (nonsteroidal antiinflammatory drugs and oral steroids)...
November 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27234945/reuma-pt-case-study
#11
EDITORIAL
Maria J Santos, Helena Canhão, Augusto Faustino, João Eurico Fonseca
No abstract text is available yet for this article.
February 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/26979603/clinical-features-and-long-term-outcomes-of-systemic-lupus-erythematosus-comparative-data-of-childhood-adult-and-late-onset-disease-in-a-national-register
#12
COMPARATIVE STUDY
S Sousa, M J Gonçalves, L S Inês, G Eugénio, D Jesus, S Fernandes, G Terroso, V C Romão, M Cerqueira, A Raposo, M Couto, P Nero, G Sequeira, T Nóvoa, J A Melo Gomes, J Canas da Silva, L Costa, C Macieira, C Silva, J A P Silva, H Canhão, M J Santos
Systemic lupus erythematosus (SLE) affects predominantly women at reproductive age but may present at any age. Age at disease onset has a modulating effect on presentation and course of disease, but controversies persist regarding its impact on long-term outcome. Our aims were to characterize clinical features, co-morbidities and cumulative damage in childhood-onset, adult-onset and late-onset SLE. Patients with childhood-onset SLE fulfilling ACR 1997 criteria were identified in a nationwide register-Reuma...
July 2016: Rheumatology International
https://www.readbyqxmd.com/read/26815727/brief-report-association-of-rheumatoid-factor-and-anti-citrullinated-protein-antibody-positivity-with-better-effectiveness-of-abatacept-results-from-the-pan-european-registry-analysis
#13
J E Gottenberg, D S Courvoisier, M V Hernandez, F Iannone, E Lie, H Canhão, K Pavelka, M L Hetland, C Turesson, X Mariette, A Finckh
OBJECTIVE: To investigate the role of rheumatoid factor (RF) status and anti-citrullinated peptide antibody (ACPA) status as predictors of abatacept (ABA) effectiveness in patients with rheumatoid arthritis (RA). METHODS: We conducted a pooled analysis of data from 9 observational RA registries in Europe (ARTIS [Sweden], ATTRA [Czech Republic], BIOBADASER [Spain], DANBIO [Denmark], GISEA [Italy], NOR-DMARD [Norway], ORA [France], Reuma.pt [Portugal], and SCQM-RA [Switzerland])...
June 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26736089/database-evaluation-of-the-association-between-serum-magnesium-levels-and-the-risk-of-atrial-fibrillation-in-the-community
#14
Noa Markovits, Daniel Kurnik, Hillel Halkin, Reuma Margalit, Martin Bialik, Yossi Lomnicky, Ronen Loebstein
BACKGROUND: In population studies, mild hypomagnesemia, determined by a single measurement, was associated with incident atrial fibrillation, over ~20 years of follow-up. We sought to determine whether mild (≤ 1.7 mg/dL) and moderate (≤ 1.5mg/dL) hypomagnesemia are temporally associated with increased incidence of atrial fibrillation (AF) in the community. METHODS: Health Maintenance Organization (HMO) database cohort study including beneficiaries with ≥ 1 serum magnesium measurement between 2004 and 2013...
February 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26460980/gender-differences-in-the-association-of-depression-with-career-indecisiveness-career-decision-status-and-career-preference-crystallization
#15
Reuma Gadassi, Ayelet Waser, Itamar Gati
Depression has detrimental effects on broad areas of functioning. However, its association with career decision-making factors has been largely unexplored. In the present study, we focused on the association between career decision-making difficulties, career-decision status, and career-preference crystallization, on the one hand, and depression, on the other. The hypothesis that high levels of career decision-making difficulties, less advanced decision status, and low levels of preference crystallization are associated with higher levels of depressive symptoms was tested with a sample of 222 college seniors...
October 2015: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/26000286/comparative-effectiveness-of-tocilizumab-and-tnf-inhibitors-in-rheumatoid-arthritis-patients-data-from-the-rheumatic-diseases-portuguese-register-reuma-pt
#16
COMPARATIVE STUDY
Vasco C Romão, Maria José Santos, Joaquim Polido-Pereira, Cátia Duarte, Patrícia Nero, Cláudia Miguel, José António Costa, Miguel Bernardes, Fernando M Pimentel-Santos, Filipe Barcelos, Lúcia Costa, José António Melo Gomes, José Alberto Pereira da Silva, Jaime Cunha Branco, José Canas da Silva, José António Pereira da Silva, João Eurico Fonseca, Helena Canhão
OBJECTIVES: To compare the effectiveness of TNF inhibitors (TNFi) and tocilizumab in rheumatoid arthritis (RA) treatment, according to different response criteria. METHODS: We included RA patients registered in the Rheumatic Diseases Portuguese Register treated with TNFi or tocilizumab for at least 6 months, between January 2008 and July 2013. We assessed remission/low disease activity (LDA) at 6 months according to DAS28, CDAI, and SDAI, as well as Boolean ACR/EULAR remission and EULAR response rate, adjusting for measured confounders...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25958338/confusing-acceptance-and-mere-politeness-depression-and-sensitivity-to-duchenne-smiles
#17
Reuma Gadassi, Nilly Mor
BACKGROUND AND OBJECTIVES: Whereas the association between depression and the perception of emotions has been widely studied, only few studies have examined the association between depression and the ability to discriminate genuine (Duchenne) from fake (non-Duchenne) smiles. The present study examined this by comparing currently depressed, previously depressed, and healthy control individuals. Guided by recent theory, the present study also investigated the effect of depression recurrence on smile identification...
March 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/25867834/explicit-and-inferred-motives-for-nonsuicidal-self-injurious-acts-and-urges-in-borderline-and-avoidant-personality-disorders
#18
Avigal Snir, Eshkol Rafaeli, Reuma Gadassi, Kathy Berenson, Geraldine Downey
Nonsuicidal self-injury (NSSI) is a perplexing phenomenon that may have differing motives. The present study used experience sampling methods (ESM) which inquired explicitly about the motives for NSSI, but also enabled a temporal examination of the antecedents/consequences of NSSI; these allow us to infer other motives which were not explicitly endorsed. Adults (n = 152, aged 18-65) with borderline personality disorder (BPD), avoidant personality disorder (APD), or no psychopathology participated in a 3-week computerized diary study...
July 2015: Personality Disorders
https://www.readbyqxmd.com/read/25680818/perceived-partner-responsiveness-mediates-the-association-between-sexual-and-marital-satisfaction-a-daily-diary-study-in-newlywed-couples
#19
Reuma Gadassi, Lior Eadan Bar-Nahum, Sarah Newhouse, Ragnar Anderson, Julia R Heiman, Eshkol Rafaeli, Erick Janssen
Sexuality is an integral part of intimate relationships, yet surprisingly little is known about how and for whom sexuality matters. The present research investigated the interplay of sexual and non-sexual factors that contribute to relationship satisfaction. Specifically, we tested the hypothesis that the association between sexual satisfaction and marital satisfaction is mediated by a non-sexual factor-namely, perceived partner responsiveness (PPR). Additionally, we tested the role of gender as a possible moderator of this mediated association...
January 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/25581417/classification-of-systemic-lupus-erythematosus-systemic-lupus-international-collaborating-clinics-versus-american-college-of-rheumatology-criteria-a-comparative-study-of-2-055-patients-from-a-real-life-international-systemic-lupus-erythematosus-cohort
#20
COMPARATIVE STUDY
Luís Inês, Cândida Silva, Maria Galindo, Francisco J López-Longo, Georgina Terroso, Vasco C Romão, Iñigo Rúa-Figueroa, Maria J Santos, José M Pego-Reigosa, Patrícia Nero, Marcos Cerqueira, Cátia Duarte, Luís C Miranda, Miguel Bernardes, Maria J Gonçalves, Coral Mouriño-Rodriguez, Filipe Araújo, Ana Raposo, Anabela Barcelos, Maura Couto, Pedro Abreu, Teresa Otón-Sanchez, Carla Macieira, Filipa Ramos, Jaime C Branco, José A P Silva, Helena Canhão, Jaime Calvo-Alén
OBJECTIVE: The new Systemic Lupus International Collaborating Clinics (SLICC) 2012 classification criteria aimed to improve the performance of systemic lupus erythematosus (SLE) classification over the American College of Rheumatology (ACR) 1997 criteria. However, the SLICC 2012 criteria need further external validation. Our objective was to compare the sensitivity for SLE classification between the ACR 1997 and the SLICC 2012 criteria sets in a real-life, multicenter, international SLE population...
August 2015: Arthritis Care & Research
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