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Filipa Oliveira-Ramos, Mónica Eusébio, Fernando M Martins, Ana Filipa Mourão, Carolina Furtado, Raquel Campanilho-Marques, Inês Cordeiro, Joana Ferreira, Marcos Cerqueira, Ricardo Figueira, Iva Brito, Helena Canhão, Maria José Santos, José A Melo-Gomes, João Eurico Fonseca
OBJECTIVES: To determine how adult juvenile idiopathic arthritis (JIA) patients fulfil classification criteria for adult rheumatic diseases, evaluate their outcomes and determine clinical predictors of inactive disease, functional status and damage. METHODS: Patients with JIA registered on the Rheumatic Diseases Portuguese Register ( older than 18 years and with more than 5 years of disease duration were included. Data regarding sociodemographic features, fulfilment of adult classification criteria, Health Assessment Questionnaire, Juvenile Arthritis Damage Index-articular (JADI-A) and Juvenile Arthritis Damage Index-extra-articular (JADI-E) damage index and disease activity were analysed...
2016: RMD Open
Pedro David Carvalho, Cátia Duarte, Elsa Vieira-Sousa, Luís Cunha-Miranda, Pedro Avila-Ribeiro, Helena Santos, Miguel Bernardes, Maria José Santos, Marcos Cerqueira, Margarida Mateus, Patrícia Nero, Ana Águeda, José António Pereira da Silva, Pedro Machado
Psoriatic arthritis (PsA) is a chronic inflammatory rheumatic disease with a broad clinical spectrum. PsA can affect the axial skeleton, peripheral joints, entheses, synovial sheaths of tendons, skin, nails and extra-articular organs. Tumour necrosis factor alpha blockers (TNF blockers) were a breakthrough development in the treatment of PsA. Identifying predictors of response to biological therapies in patients with PsA is of utmost importance, especially in view of the costs and potential side effects of these agents...
August 17, 2016: Acta Reumatológica Portuguesa
Haran Sened, Iftah Yovel, Eran Bar-Kalifa, Reuma Gadassi, Eshkol Rafaeli
Recent research on empathy finds evidence for 2 different pathways that enable individuals to accurately infer other persons' inner mental states: an automatic, indirect pathway that operates by having a mental state similar to the target's and (correctly) assuming that this state is similar to the target's, and a more controlled direct pathway that involves assessing the target's mental state with no regard for one's own. We present 3 daily diary studies (N = 53, 38 and 80 couples) examining the contribution of these pathways to empathic accuracy in daily assessments of romantic partners' negative moods, and examine the effects of gender and relational conflict on these pathways...
August 25, 2016: Emotion
Adi Granat, Reuma Gadassi, Eva Gilboa-Schechtman, Ruth Feldman
Maternal postpartum depression (PPD) exerts long-term negative effects on infants; yet the mechanisms by which PPD disrupts emotional development are not fully clear. Utilizing an extreme-case design, 971 women reported symptoms of depression and anxiety following childbirth and 215 high and low on depressive symptomatology reported again at 6 months. Of these, mothers diagnosed with major depressive disorder (n = 22), anxiety disorders (n = 19), and controls (n = 59) were visited at 9 months. Mother-infant interaction was microcoded for maternal and infant's social behavior and synchrony...
July 21, 2016: Emotion
Alexandre Sepriano, Sofia Ramiro, Désirée van der Heijde, Pedro Ávila-Ribeiro, Rita Fonseca, Joana Borges, Lídia Teixeira, Pedro Carvalho, Marcos Cerqueira, Joana Neves, Tiago Meirinhos, Anabela Barcelos, Graça Sequeira, Maria João Salvador, José António Canas da Silva, Helena Santos, Miguel Bernardes, Elsa Vieira-Sousa, Helena Canhão, Jaime C Branco, Fernando Pimentel-Santos, Robert Landewé
OBJECTIVE: To evaluate if comedication with conventional synthetic disease modifying antirheumatic drugs (csDMARD) influences TNFi-retention in patients with spondyloarthritis (SpA). METHODS: Patients with SpA from the Rheumatic Diseases Portuguese Register (, with first TNFi started between 2001 and 2014 were included in this study. Cox-regression was used to estimate the effect of csDMARD comedication on TNFi-retention in two types of models, one including baseline (time-fixed) variables and the other with time-varying variables, including socio-demographic features, measures of disease activity, physical function and co-treatment with other drugs (NSAIDs and oral steroids)...
June 6, 2016: Arthritis & Rheumatology
Maria J Santos, Helena Canhão, Augusto Faustino, João Eurico Fonseca
No abstract text is available yet for this article.
February 2016: Acta Médica Portuguesa
S Sousa, M J Gonçalves, L S Inês, G Eugénio, D Jesus, S Fernandes, G Terroso, V C Romão, M Cerqueira, A Raposo, M Couto, P Nero, G Sequeira, T Nóvoa, J A Melo Gomes, J Canas da Silva, L Costa, C Macieira, C Silva, J A P Silva, H Canhão, M J Santos
Systemic lupus erythematosus (SLE) affects predominantly women at reproductive age but may present at any age. Age at disease onset has a modulating effect on presentation and course of disease, but controversies persist regarding its impact on long-term outcome. Our aims were to characterize clinical features, co-morbidities and cumulative damage in childhood-onset, adult-onset and late-onset SLE. Patients with childhood-onset SLE fulfilling ACR 1997 criteria were identified in a nationwide register-Reuma...
July 2016: Rheumatology International
J E Gottenberg, D S Courvoisier, M V Hernandez, F Iannone, E Lie, H Canhão, K Pavelka, M L Hetland, C Turesson, X Mariette, A Finckh
OBJECTIVE: To investigate the role of rheumatoid factor (RF) status and anti-citrullinated peptide antibody (ACPA) status as predictors of abatacept (ABA) effectiveness in patients with rheumatoid arthritis (RA). METHODS: We conducted a pooled analysis of data from 9 observational RA registries in Europe (ARTIS [Sweden], ATTRA [Czech Republic], BIOBADASER [Spain], DANBIO [Denmark], GISEA [Italy], NOR-DMARD [Norway], ORA [France], [Portugal], and SCQM-RA [Switzerland])...
June 2016: Arthritis & Rheumatology
Noa Markovits, Daniel Kurnik, Hillel Halkin, Reuma Margalit, Martin Bialik, Yossi Lomnicky, Ronen Loebstein
BACKGROUND: In population studies, mild hypomagnesemia, determined by a single measurement, was associated with incident atrial fibrillation, over ~20 years of follow-up. We sought to determine whether mild (≤ 1.7 mg/dL) and moderate (≤ 1.5mg/dL) hypomagnesemia are temporally associated with increased incidence of atrial fibrillation (AF) in the community. METHODS: Health Maintenance Organization (HMO) database cohort study including beneficiaries with ≥ 1 serum magnesium measurement between 2004 and 2013...
February 15, 2016: International Journal of Cardiology
Reuma Gadassi, Ayelet Waser, Itamar Gati
Depression has detrimental effects on broad areas of functioning. However, its association with career decision-making factors has been largely unexplored. In the present study, we focused on the association between career decision-making difficulties, career-decision status, and career-preference crystallization, on the one hand, and depression, on the other. The hypothesis that high levels of career decision-making difficulties, less advanced decision status, and low levels of preference crystallization are associated with higher levels of depressive symptoms was tested with a sample of 222 college seniors...
October 2015: Journal of Counseling Psychology
Vasco C Romão, Maria José Santos, Joaquim Polido-Pereira, Cátia Duarte, Patrícia Nero, Cláudia Miguel, José António Costa, Miguel Bernardes, Fernando M Pimentel-Santos, Filipe Barcelos, Lúcia Costa, José António Melo Gomes, José Alberto Pereira da Silva, Jaime Cunha Branco, José Canas da Silva, José António Pereira da Silva, João Eurico Fonseca, Helena Canhão
OBJECTIVES: To compare the effectiveness of TNF inhibitors (TNFi) and tocilizumab in rheumatoid arthritis (RA) treatment, according to different response criteria. METHODS: We included RA patients registered in the Rheumatic Diseases Portuguese Register treated with TNFi or tocilizumab for at least 6 months, between January 2008 and July 2013. We assessed remission/low disease activity (LDA) at 6 months according to DAS28, CDAI, and SDAI, as well as Boolean ACR/EULAR remission and EULAR response rate, adjusting for measured confounders...
2015: BioMed Research International
Reuma Gadassi, Nilly Mor
BACKGROUND AND OBJECTIVES: Whereas the association between depression and the perception of emotions has been widely studied, only few studies have examined the association between depression and the ability to discriminate genuine (Duchenne) from fake (non-Duchenne) smiles. The present study examined this by comparing currently depressed, previously depressed, and healthy control individuals. Guided by recent theory, the present study also investigated the effect of depression recurrence on smile identification...
March 2016: Journal of Behavior Therapy and Experimental Psychiatry
Avigal Snir, Eshkol Rafaeli, Reuma Gadassi, Kathy Berenson, Geraldine Downey
Nonsuicidal self-injury (NSSI) is a perplexing phenomenon that may have differing motives. The present study used experience sampling methods (ESM) which inquired explicitly about the motives for NSSI, but also enabled a temporal examination of the antecedents/consequences of NSSI; these allow us to infer other motives which were not explicitly endorsed. Adults (n = 152, aged 18-65) with borderline personality disorder (BPD), avoidant personality disorder (APD), or no psychopathology participated in a 3-week computerized diary study...
July 2015: Personality Disorders
Reuma Gadassi, Lior Eadan Bar-Nahum, Sarah Newhouse, Ragnar Anderson, Julia R Heiman, Eshkol Rafaeli, Erick Janssen
Sexuality is an integral part of intimate relationships, yet surprisingly little is known about how and for whom sexuality matters. The present research investigated the interplay of sexual and non-sexual factors that contribute to relationship satisfaction. Specifically, we tested the hypothesis that the association between sexual satisfaction and marital satisfaction is mediated by a non-sexual factor-namely, perceived partner responsiveness (PPR). Additionally, we tested the role of gender as a possible moderator of this mediated association...
January 2016: Archives of Sexual Behavior
Luís Inês, Cândida Silva, Maria Galindo, Francisco J López-Longo, Georgina Terroso, Vasco C Romão, Iñigo Rúa-Figueroa, Maria J Santos, José M Pego-Reigosa, Patrícia Nero, Marcos Cerqueira, Cátia Duarte, Luís C Miranda, Miguel Bernardes, Maria J Gonçalves, Coral Mouriño-Rodriguez, Filipe Araújo, Ana Raposo, Anabela Barcelos, Maura Couto, Pedro Abreu, Teresa Otón-Sanchez, Carla Macieira, Filipa Ramos, Jaime C Branco, José A P Silva, Helena Canhão, Jaime Calvo-Alén
OBJECTIVE: The new Systemic Lupus International Collaborating Clinics (SLICC) 2012 classification criteria aimed to improve the performance of systemic lupus erythematosus (SLE) classification over the American College of Rheumatology (ACR) 1997 criteria. However, the SLICC 2012 criteria need further external validation. Our objective was to compare the sensitivity for SLE classification between the ACR 1997 and the SLICC 2012 criteria sets in a real-life, multicenter, international SLE population...
August 2015: Arthritis Care & Research
Ana F Mourão, Maria J Santos, José Melo-Gomes, Fernando M Martins, José A Costa, Filipa Ramos, Iva Brito, Cátia Duarte, Ricardo Figueira, Guilherme Figueiredo, Carolina Furtado, Ana Lopes, Margarida Oliveira, Ana Rodrigues, Manuel Salgado, Miguel Sousa, Jamie C Branco, João E Fonseca, Helena Canhão
OBJECTIVE: Our aims were to evaluate the correlation between Juvenile Arthritis Disease Activity Score 27-joint reduced count (JADAS27) with erythrocyte sedimentation rate (ESR) and JADAS27 with C-reactive protein (CRP) scores and to test the agreement of both scores on classifying each disease activity state. We also aimed at verifying the correlation of the 2 scores across juvenile idiopathic arthritis (JIA) categories and to check the correlation between JADAS27-ESR and clinical JADAS27 (JADAS27 without ESR)...
April 2014: Arthritis Care & Research
M J Gonçalves, S Sousa, L S Inês, C Duarte, J Borges, C Silva, V C Romão, G Terroso, M Bernardes, M Cerqueira, A Raposo, G Sequeira, A Barcelos, C Macieira, J Canas da Silva, L Costa, J A Pereira da Silva, L Cunha-Miranda, J A P Da Silva, H Canhão, M J Santos
BACKGROUND: Although the survival rate has considerably improved, many patients with systemic lupus erythematosus (SLE) develop irreversible organ damage. OBJECTIVES: The objectives of this paper are to characterize cumulative damage in SLE patients and identify variables associated with its presence and severity. METHODS: A cross-sectional analysis of SLE patients from the Portuguese Lupus register in whom damage assessment using the SLICC/ACR-Disability Index (SDI) was available was performed...
March 2015: Lupus
Fernando M Martins, José António Pereira da Silva, Maria José Santos, Elsa Vieira-Sousa, Cátia Duarte, Helena Santos, José António Costa, Fernando M Pimentel-Santos, Inês Cunha, Luís Cunha Miranda, Teresa Nóvoa, Margarida Cruz, Miguel Bernardes, Domingos Araujo, José Alberto Pereira Silva, José Canas Silva, Jaime Cunha Branco, José António Melo Gomes, Augusto Faustino, João Eurico Fonseca, Helena Canhão
OBJECTIVES: . The 28-joint DAS (DAS28), clinical disease activity index (CDAI) and simplified disease activity index (SDAI) are indices frequently used to assess disease activity in RA patients. Cut-off values were defined to classify the states of RA disease activity: remission, low, moderate and high. The aim of this work was to assess disease activity states classified by DAS28, CDAI and SDAI and to analyse their agreement in the Rheumatic Diseases Portuguese Register METHODS: ...
February 2015: Rheumatology
Reuma Gadassi, Avigal Snir, Kathy Berenson, Geraldine Downey, Eshkol Rafaeli
Social proximity typically helps individuals meet their belongingness needs, but several forms of psychopathology, including borderline and avoidant personality disorders (BPD and APD, respectively) are characterized by social difficulties. This experience-sampling study is one of the first to directly investigate the affective reactions of individuals with BPD and APD (compared with healthy controls [HC]) to social proximity in daily life. We examined both person-level and day-level reactions. At the person level, the rate of social proximity across the diary period was associated with diminished feelings of rejection, isolation, shame, and dissociation in the HC group...
August 2014: Journal of Abnormal Psychology
João Eurico Fonseca, João Gonçalves, Filipe Araújo, Inês Cordeiro, Filipa Teixeira, Helena Canhão, José António Pereira da Silva, Sandra Garcês, Luís Cunha Miranda, Sofia Ramiro, Ana Roxo, Fernando M Pimentel-Santos, Viviana Tavares, Adriano Neto, Alexandre Sepriano, Armando Malcata, Augusto Faustino, Cândida Silva, Catarina Ambrósio, Cátia Duarte, Cláudia Miguel, Filipe Barcelos, Helena Santos, Inês Cunha, João Carlos Ramos, José António Melo Gomes, José Bravo Pimentão, Lúcia Costa, Luís Maurício, Margarida Silva, Miguel Bernardes, Mónica Bogas, Paulo Clemente Coelho, Paulo Monteiro, Renata Aguiar, Rui André, Rui Leitão, Sofia Pimenta, Tiago Meirinhos, Susana Fernandes, Vera Las, Walter Castelão
Biotechnological drugs have become a fundamental resource for the treatment of rheumatic patients. Patent expiry of some of these drugs created the opportunity for biopharmaceutical manufacturers to develop biosimilar drugs intended to be as efficacious as the originator product but with a lower cost to healthcare systems. Due to the complex manufacturing process and highly intricate structure of biologicals, a biosimilar can never be an exact copy of its reference product. Consequently, regulatory authorities issued strict preclinical and clinical guidelines to ensure safety and efficacy equivalence and, in September 2013, the biosimilar of infliximab was the first biosimilar monoclonal antibody to be authorized for use in the European Union...
January 2014: Acta Reumatológica Portuguesa
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