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Cervical Adjustments

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https://www.readbyqxmd.com/read/28432016/inkjet-printing-of-antiviral-pcl-nanoparticles-and-anticancer-cyclodextrin-inclusion-complexes-on-bioadhesive-film-for-cervical-administration
#1
Cem Varan, Henrika Wickström, Niklas Sandler, Yeşim Aktaş, Erem Bilensoy
Personalized medicine is an important treatment approach for diseases like cancer with high intrasubject variability. In this framework, printing is one of the most promising methods since it permits dose and geometry adjustment of the final product. With this study, a combination product consisting of anticancer (paclitaxel) and antiviral (cidofovir) drugs was manufactured by inkjet printing onto adhesive film for local treatment of cervical cancers as a result of HPV infection. Furthermore, solubility problem of paclitaxel was overcome by maintaining this poorly soluble drug in a cyclodextrin inclusion complex and release of cidofovir was controlled by encapsulation in polycaprolactone nanoparticles...
April 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28412897/rates-of-cervical-cancer-screening-among-women-with-severe-mental-illness-in-the-public-health-system
#2
Monique James, Melanie Thomas, Latoya Frolov, Nicholas S Riano, Eric Vittinghoff, Dean Schillinger, John W Newcomer, Christina Mangurian
OBJECTIVE: This study aimed to determine cervical cancer screening rates among women with severe mental illness. METHODS: California Medicaid administrative records (2010-2011) for 31,308 women with severe mental illness were examined. Participants received specialty mental health services and were not dually eligible for Medicare. Poisson models assessed association between selected predictors and cervical cancer screening. RESULTS: Overall, 20...
April 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28411326/neck-muscle-emg-force-relationship-and-its-reliability-during-isometric-contractions
#3
Riccardo Lo Martire, Kristofer Gladh, Anton Westman, Björn O Äng
BACKGROUND: Susceptible to injury, the neck is subject to scientific investigations, frequently aiming to elucidate possible injury mechanisms via surface electromyography (EMG) by indirectly estimating cervical loads. Accurate estimation requires that the EMG-force relationship is known and that its measurement error is quantified. Hence, this study examined the relationship between EMG and isometric force amplitude of the anterior neck (AN), the upper posterior neck (UPN), and the lower posterior neck (LPN) and then assessed the relationships' test-retest reliability across force-percentiles within and between days...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28404931/a-retrospective-analysis-of-the-utility-of-endocervical-curettage-in-screening-population
#4
Yan Song, Yu-Qian Zhao, Ling Li, Qin-Jin Pan, Nan Li, Fang-Hui Zhao, Wen Chen, Xun Zhang, You-Lin Qiao
The performance of endocervical curettage (ECC) is a dispute in population screening programs. Data of 3,460 women referred to colposcopy examination and had completed pathological results in the Shanxi Province Cervical Cancer Screening Study I and II were reviewed. Among them, 0.6% and 2.7% women were identified as the histopathological confirmed high-grade squamous intraepithelial lesion or worse (HSIL+) by ECC alone or both ECC and quadrants biopsy respectively. Age, cytology, and colposcopy impression are the impact factors for the HSIL+ yield of ECC (P<0...
February 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402732/different-methods-for-inlay-production-effect-on-internal-and-marginal-adaptation-adjustment-time-and-contact-point
#5
M P Rippe, C Monaco, L Volpe, M A Bottino, R Scotti, L F Valandro
The aim of this study was to evaluate the effect of different production methods of resin and ceramic inlays on marginal and internal adaptation, adjustment time, and proximal contacts. Forty premolars were selected, embedded (their roots), and prepared to receive inlays that were made as follows (n=10): LaRe-digital impression with a Lava C.O.S. scanner, followed by milling of Lava Ultimate block (composite resin) in a milling center; CeRe-digital impression with a Cerec 3D Bluecam scanner, followed by milling of Lava Ultimate block in Cerec; CeDis-digital impression with a Cerec 3D Bluecam scanner, followed by milling of IPS e...
April 12, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28400724/influence-of-cervical-spine-mobility-on-the-focal-and-postural-components-of-the-sit-to-stand-task
#6
Alain Hamaoui, Caroline Alamini-Rodrigues
The aim of this study was to determine the influence of cervical spine mobility on the focal and postural components of the sit-to-stand transition, which represent the preparatory and execution phases of the task, respectively. Sixteen asymptomatic female participants (22 ± 3 years, 163 ± 0,06 cm, 57,5 ± 5 kg), free of any neurological or musculoskeletal disorders, performed six trials of the sit-to-stand task at maximum speed, in four experimental conditions varying the mobility of the cervical spine by means of three different splints...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28393580/second-trimester-cervical-length-and-outcomes-of-induction-of-labor-at-term
#7
Rupsa C Boelig, Anju Suhag, Juliana Guarente, Kelly Orzechowski, Vincenzo Berghella
OBJECTIVE: To evaluate whether second-trimester cervical length (CL) is associated with induction of labor (IOL) outcomes. METHODS: Retrospective cohort study of nulliparous singletons undergoing CL screening at 18 0/7-23 6/7 weeks from 1/1/2012 to 12/31/2013. Women induced at term (≥37 weeks) were included. Primary outcome was vaginal delivery (VD) within 24 h. The effect of CL on outcomes was assessed by incidence across CL quartiles and a receiver operating characteristics (ROC) curve...
April 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28382554/measurement-of-vertebral-bone-marrow-proton-density-fat-fraction-in-children-using-quantitative-water-fat-mri
#8
Stefan Ruschke, Amber Pokorney, Thomas Baum, Holger Eggers, Jeffrey H Miller, Houchun H Hu, Dimitrios C Karampinos
OBJECTIVES: To investigate the feasibility of employing a 3D time-interleaved multi-echo gradient-echo (TIMGRE) sequence to measure the proton density fat fraction (PDFF) in the vertebral bone marrow (VBM) of children and to examine cross-sectional changes with age and intra-individual variations from the lumbar to the cervical region in the first two decades of life. MATERIALS AND METHODS: Quantitative water-fat imaging of the spine was performed in 93 patients (49 girls; 44 boys; age median 4...
April 5, 2017: Magma
https://www.readbyqxmd.com/read/28381489/parallel-processing-of-internal-and-external-feedback-in-the-spinocerebellar-system-of-primates
#9
Oren Cohen, Ran Harel, Timothy D Aumann, Zvi Israel, Yifat Prut
Cerebellar control of voluntary movements is achieved by the integration of external and internal feedback information to properly adjust and correct ongoing actions. In the forelimb of primates, rostral-spinocerebellar tract (RSCT) neurons are thought to integrate segmental, descending and afferent sources and relay upstream a compound signal that contains both an efference copy of the spinal-level motor command and the state of the periphery. We tested this hypothesis by implanting stimulating electrodes in the superior cerebellar peduncle (SCP) and recording the activity of cervical spinal neurons in primates...
April 5, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28378404/a-cross-sectional-study-on-hpv-testing-with-type-16-18-genotyping-for-cervical-cancer-screening-in-11-064-chinese-women
#10
Qiongyan Wu, Xiumin Zhao, Yunfeng Fu, Xinyu Wang, Xiaofei Zhang, Xun Tian, Bei Cheng, Bingjian Lu, Xiao Yu, Suqiu Lan, Weiguo Lu, Ding Ma, Xiaodong Cheng, Xing Xie
Cytology-based cervical cancer screening is restricted because of a lack of cytologists. Thus, HPV-based instead of cytology-based screening may be a more suitable strategy in China. Here, we assessed the effectiveness of HPV testing (Cobas(®) 4800 Test, Roche) and HPV-based programs to detect high-grade cervical intraepithelial neoplasia (CIN) or cancer compared with cytology (Thinprep, Hologic) and cytology-based programs through a cross-sectional study in 11,064 Chinese women aged 21-65 years who were enrolled from Longyou County in Zhejiang Province, China...
April 4, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28378200/determinants-of-cancer-screening-disparities-among-asian-americans-a-systematic-review-of-public-health-surveys
#11
Jungmi Jun, Xiaoli Nan
We conducted a systematic analysis of 24 peer-reviewed literary works that examined Asian Americans' breast, cervical, and colon cancer screening, focusing on empirical findings from large-scale public health surveys (i.e., NHIS, CHIS, HINTS, BRFSS). We provide an overview of relevant research in terms of study characteristics, samples, predictor/covariate of cancer screenings, and key findings. Our analysis indicates that Asian Americans' cancer screening rates are lower than for non-Hispanic Whites for all cancer types in four large-scale public health surveys throughout 17 study years...
April 5, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28377861/outpatient-anterior-cervical-discectomy-and-fusion-an-analysis-of-readmissions-from-the-new-jersey-state-ambulatory-services-database
#12
Shearwood McClelland, Peter G Passias, Thomas J Errico, R Shay Bess, Themistocles S Protopsaltis
BACKGROUND: Anterior cervical discectomy and fusion (ACDF) performed as an outpatient has become increasingly common for treating cervical spine pathology. Few reports have attempted to assess readmissions following outpatient ACDF. This study was performed to address this issue using population-based databases. METHODS: The State Ambulatory Services Database (SASD) for New Jersey (NJ) from 2003-2012 was used for analysis. Patients receiving ACDF (defined as anterior cervical fusion (ICD-0 code=81...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28376438/those-left-behind-from-voluntary-medical-home-reforms-in-ontario-canada
#13
Tara Kiran, Alexander Kopp, Richard H Glazier
PURPOSE: Health systems are transitioning patients to medical homes to improve health outcomes and reduce cost. We sought to understand the characteristics and quality of care for patients who did and did not participate in the voluntary transition to medical homes. METHODS: We used administrative data for diabetes monitoring and cancer screening to compare services received by patients attached to a medical home (n = 10,785,687) with services received by those seeing a fee-for-service physician (n = 1,321,800) in Ontario, Canada, on March 31, 2011...
November 2016: Annals of Family Medicine
https://www.readbyqxmd.com/read/28376222/optimal-cervical-cancer-screening-in-women-vaccinated-against-human-papillomavirus
#14
Jane J Kim, Emily A Burger, Stephen Sy, Nicole G Campos
Background: Current US cervical cancer screening guidelines do not differentiate recommendations based on a woman's human papillomavirus (HPV) vaccination status. Changes to cervical cancer screening policies in HPV-vaccinated women should be evaluated. Methods: We utilized an individual-based mathematical model of HPV and cervical cancer in US women to project the health benefits, costs, and harms associated with screening strategies in women vaccinated with the bivalent, quadrivalent, or nonavalent vaccine...
February 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28375481/dose-escalation-of-definitive-radiation-is-not-associated-with-improved-survival-for-cervical-esophageal-cancer-a-national-cancer-data-base-ncdb-analysis
#15
B De, R Rhome, J Doucette, M Buckstein
For cervical esophageal cancer (CEC), National Comprehensive Cancer Network guidelines support RT to 50-50.4 Gy with chemotherapy but acknowledge higher doses may be appropriate. This study uses the National Cancer Database (NCDB) to characterize RT practices and identify if a dose-response relationship exists for overall survival (OS) for definitive treatment of CEC. We queried the NCDB for patients diagnosed with Stage I-III CEC from 2004 to 2013, and selected patients receiving definitive RT with doses between 50 and 74 Gy...
April 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28374937/physical-after-effects-of-colposcopy-and-related-procedures-and-their-inter-relationship-with-psychological-distress-a-longitudinal-survey
#16
Mairead O'Connor, Katie O'Brien, Jo Waller, Pamela Gallagher, Tom D'Arcy, Grainne Flannelly, Cara M Martin, Judith McRae, Walter Prendiville, Carmel Ruttle, Christine White, Loretto Pilkington, John J O'Leary, Linda Sharp
OBJECTIVES: To estimate prevalence of post-colposcopy physical after-effects and investigate associations between these and subsequent psychological distress. DESIGN: Longitudinal survey. SETTING: Two hospital-based colposcopy clinics. POPULATION: Women with abnormal cytology who underwent colposcopy (+/- related procedures). METHODS: Questionnaires were mailed to women 4-, 8- and 12-months post-colposcopy...
April 4, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28373252/factors-associated-with-participation-in-cervical-cancer-screening-among-young-koreans-a-nationwide-cross-sectional-study
#17
Ha Kyun Chang, Jun-Pyo Myong, Seung Won Byun, Sung-Jong Lee, Yong Seok Lee, Hae-Nam Lee, Keun Ho Lee, Dong Choon Park, Chan Joo Kim, Soo Young Hur, Jong Sup Park, Tae Chul Park
OBJECTIVES: Despite the possibility of early detection of cervical cancer, participation in screening programmes among young Koreans is low. We sought to identify associations between risk factors and participation in screening for cervical cancer among young Koreans. DESIGN: Nationwide cross-sectional study. SETTING: Republic of Korea. PARTICIPANTS: 3734. MAIN OUTCOME MEASURES: The Korea National Health and Nutrition Examination Survey (KNHANES V: 2010-2012) was used to evaluate factors associated with attendance for cervical cancer screening among women aged 15-39...
April 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28371054/incidence-and-predictors-of-cancer-following-kidney-transplantation-in-childhood
#18
A Francis, D W Johnson, J C Craig, G Wong
Cancer risk is increased substantially in adult kidney transplant recipients, but the long-term risk of cancer in childhood recipients is unclear. Using the Australian and New Zealand Dialysis and Transplant Registry, the overall and site-specific incidences of cancer after transplantation in childhood recipients were compared with population-based data using standardized incidence ratios (SIR). Among 1734 childhood recipients (median age 14 years, 57% male, 85% white), 289 (16.7%) developed cancer (196 non-melanoma skin cancers, 143 non-skin cancers) over a median follow-up of 13...
March 29, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28368798/-risks-factors-of-cesarean-delivery-after-3hours-of-delayed-pushing
#19
S Cheniere, S Ménard, M-C Lamau, F Goffinet, C Le Ray
OBJECTIVES: Identify the factors associated with caesarean delivery for unengaged fetal head beyond 3hours of passive second stage of labor, among primiparous patients. METHODS: A case-control study conducted in level III universitary center between October 2012 and September 2015. Only primiparous at term, with a singleton, cephalic fetus and a passive second stage of labor prolonged over 3hours before pushing were included. During the second stage of labor, patients who had caesarean for abnormal fetal heart rate were excluded...
February 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28368529/understanding-united-states-investigational-device-exemption-studies-clinical-relevance-and-importance-for-healthcare-economics
#20
Jared D Ament, Scott Mollan, Krista Greenan, Tamar Binyamin, Kee D Kim
INTRODUCTION: The US Food and Drug Administration allows a previously unapproved device to be used clinically to collect safety and effectiveness data under their Investigational Device Exemption (IDE) category. The process usually falls under 3 different trial categories: noninferiority, equivalency, and superiority. To confidently inform our patients, understanding the basic concepts of these trials is paramount. The purpose of this manuscript was to provide a comprehensive review of these topics using recently published IDE trials and economic analyses of cervical total disc replacement as illustrative examples...
March 28, 2017: Neurosurgery
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