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Cervical Adjustments

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https://www.readbyqxmd.com/read/27903956/global-burden-of-all-cause-and-cause-specific-mortality-due-to-smokeless-tobacco-use-systematic-review-and-meta-analysis
#1
Dhirendra N Sinha, Rizwan A Suliankatchi, Prakash C Gupta, Thaksaphon Thamarangsi, Naveen Agarwal, Mark Parascandola, Ravi Mehrotra
OBJECTIVES: To systematically review and meta-analyse the studies investigating the association between smokeless tobacco (SLT) use and all-cause mortality and cause-specific mortality outcomes among adult users of SLT and estimate the number of attributable deaths worldwide. METHODS: Random-effects meta-analysis was used to estimate the pooled risk of death due to SLT use. Population attributable fractions were derived and used to calculate the number of attributable deaths...
November 30, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27899201/revisiting-milan-cervical-cancer-study-do-the-original-findings-hold-in-the-era-of-chemotherapy
#2
W Ross Green, Lara Hathout, Atif J Khan, Mohamed A Elshaikh, Sushil Beriwal, William Small, Omar Mahmoud
BACKGROUND: The primary treatment of early stage cervical carcinoma (IB-IIA) is either surgery or radiation therapy based on the pivotal Milan randomized study published twenty years ago. In the presence of high-risk features, the gold standard treatment is concurrent chemotherapy and radiation therapy (CRT) whether it is the in the postoperative or the definitive setting. Using the National Cancer Data Base (NCDB), the goal of our study is to compare the outcomes of surgery and radiation therapy in the chemotherapy era...
November 26, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27895514/success-rate-in-preterm-uterine-contraction-inhibition-with-tocolytic-agents-in-a-tertiary-care-center
#3
Duangsamorn Kiatsuda, Jadsada Thinkhamrop, Witoon Prasertcharoensuk
OBJECTIVE: This study aims to assess the success rate of inhibiting preterm uterine contraction with tocolytic agents to delay delivery for at least 48 hours and risk factors of failure inhibition. MATERIALS AND METHODS: Between January 2013 and July 2014, medical records of all singleton pregnant women between 24 (0/7) and 33 (6/7) weeks of gestation with the diagnosis of preterm labor (with cervical dilatation) or threatened preterm labor (without cervical dilatation) who received tocolytic agents were reviewed...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27894753/association-between-timing-of-cervical-excision-procedure-to-minimally-invasive-hysterectomy-and-surgical-complications
#4
Stephanie A Sullivan, Leslie H Clark, Allison S Staley, Arthur-Quan Tran, Aaron Winn, Kenneth H Kim
OBJECTIVE: To determine if the time interval between excision procedure and definitive minimally invasive surgery (MIS) for cervical cancer impacts 30-day postoperative complications. METHODS: A retrospective cohort of patients diagnosed with cervical cancer from January 2000 to July 2015 was evaluated. Patients who underwent a cervical excision procedure followed by definitive MIS within 90days were included. Early definitive surgery was defined as ≤6 weeks following excision procedure, while delayed was defined as 6weeks to 3months...
November 25, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27893679/pelvic-inflammatory-disease-increases-the-risk-of-a-second-primary-malignancy-in-patients-with-cervical-cancer-treated-by-surgery-alone
#5
Wen-Yen Chiou, Chien-An Chen, Moon-Sing Lee, Hon-Yi Lin, Chung-Yi Li, Yu-Chieh Su, Shiang-Jiun Tsai, Shih-Kai Hung
As the number of long-term cervical cancer survivors continues to increase because of improvements in treatment, concerns about second primary malignancy have grown. The high-risk area of second primary cancers in cervical cancer survivors is the pelvis. Pelvic inflammatory disease (PID) could be a useful marker for gynecological cancers. Thus, we designed a large-scale, nationwide, controlled cohort study to investigate whether PID or other risk factors increased the risk of second primary cancers in patients with cervical cancer treated by surgery alone...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27885477/impact-of-old-age-on-patient-report-outcomes-and-cost-utility-for-anterior-cervical-discectomy-and-fusion-surgery-for-degenerative-spine-disease
#6
Silky Chotai, Scott L Parker, J Alex Sielatycki, Ahilan Sivaganesan, Harrison L Kay, Joseph B Wick, Matthew J McGirt, Clinton J Devin
PURPOSE: With growing older population and increasing rates of cervical spinal surgery, it is vital to understand the value of cervical surgery in this population. We set forth to determine the cost utility following anterior cervical decompression and fusion (ACDF) for degenerative disease in older patients. METHODS: Patients undergoing ACDF for degenerative diseases were enrolled into prospective longitudinal registry. Patient-reported outcomes (PROs) were recorded at baseline, 1-year, and 2-year postoperatively...
November 24, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27884038/is-there-an-association-between-body-mass-index-and-cervical-length-implications-for-obesity-and-cervical-length-management-in-pregnancy
#7
Kartik K Venkatesh, David E Cantonwine, Chloe Zera, Melanie Arjona, Nicole A Smith, Julian N Robinson, Thomas F McElrath
Objective Obesity and cervical insufficiency are leading causes of morbidity in pregnancy. We assess the relationship between maternal body mass index (BMI) and second-trimester cervical length. Methods A secondary analysis of a nested case-control study of women with singleton gestations enrolled from 2006 to 2008. The primary exposure was first-trimester BMI, categorized per World Health Organization criteria: normal (18.5 to ≤ 25 kg/m(2)), overweight (25 to ≤ 30 kg/m(2)), and obese (> 30 kg/m(2))...
November 24, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27881267/cost-utility-analysis-of-human-papillomavirus-vaccination-and-cervical-screening-on-cervical-cancer-patient-in-indonesia
#8
Didik Setiawan, Franklin Christiaan Dolk, Auliya A Suwantika, Tjalke Arend Westra, Jan C WIlschut, Maarten Jacobus Postma
BACKGROUND: Although cervical cancer is a preventable disease, the clinical and economic burdens of cervical cancer are still substantial issues in Indonesia. OBJECTIVES: The main purpose of this study was to model the costs, clinical benefits, and cost-utility of both visual inspection with acetic acid (VIA) screening alone and human papillomavirus (HPV) vaccination in addition to VIA screening in Indonesia. METHODS: We developed a population-based Markov model, consisting of three health states (susceptible, cervical cancer, and death), to assess future costs, health effects, and the cost-utility of cervical cancer prevention strategies in Indonesia...
May 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27876383/helmet-use-and-injury-severity-among-pediatric-skiers-and-snowboarders-in-colorado
#9
Melissa Milan, Sandeep Jhajj, Camille Stewart, Laura Pyle, Steven Moulton
INTRODUCTION: Skiing and snowboarding are popular winter recreational activities that are commonly associated with orthopedic type injuries. Unbeknownst to most parents, however, are the significant but poorly described risks for head, cervical spine and solid organ injuries. Although helmet use is not mandated for skiers and snowboarders outside of resort sponsored activities, we hypothesized that helmet use is associated with a lower risk of severe head injury, shorter ICU stay and shorter hospital length of stay...
November 6, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27876019/a-systematic-comparison-of-copy-number-alterations-in-four-types-of-female-cancer
#10
Fatemeh Kaveh, Lars O Baumbusch, Daniel Nebdal, Anne-Lise Børresen-Dale, Ole Christian Lingjærde, Hege Edvardsen, Vessela N Kristensen, Hiroko K Solvang
BACKGROUND: Detection and localization of genomic alterations and breakpoints are crucial in cancer research. The purpose of this study was to investigate, in a methodological and biological perspective, different female, hormone-dependent cancers to identify common and diverse DNA aberrations, genes, and pathways. METHODS: In this work, we analyzed tissue samples from patients with breast (n = 112), ovarian (n = 74), endometrial (n = 84), or cervical (n = 76) cancer...
November 22, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27874187/performance-of-a-new-hpv-and-biomarker-assay-in-management-of-hrhpv-positive-women-subanalysis-of-the-ongoing-multicenter-trace-clinical-trial-n-6-000-to-evaluate-pou4f3-as-a-potential-biomarker-of-cervical-precancer-and-cancer
#11
Adrienn Kocsis, Tibor Takács, Csaba Jeney, Zsuzsa Schaff, Róbert Koiss, Balázs Járay, Gábor Sobel, Károly Pap, István Székely, Tamás Ferenci, Hung-Cheng Lai, Miklós Nyíri, Márta Benczik
The ongoing TRACE prospective, multicenter study aimed to provide a clinical evaluation of the CONFIDENCE™ assay, which comprises an HPV DNA and a human epigenetic biomarker test. Between 2013 and 2015 over 6,000 women aged 18 or older were recruited in Hungary. Liquid based cytology, hrHPV DNA detection and single target host-gene methylation test of the promoter sequence of the POU4F3 gene by quantitative methylation specific PCR were performed from the same LBC sample. The current analysis is focused on the baseline cross-sectional clinical results of 5,384 LBC samples collected from subjects aged 25 years or older...
November 22, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27870806/outpatientanterior-cervical-discectomy-and-fusion-is-associated-with-fewer-short-term-complications-inone-and-two-level-cases-a-propensity-adjusted-analysis
#12
Michael C Fu, Jordan A Gruskay, Andre M Samuel, Evan D Sheha, Peter B Derman, Sravisht Iyer, Jonathan N Grauer, Todd J Albert
STUDY DESIGN: Retrospective cohort study of prospectively-collected data from the National Surgical Quality Improvement Program (NSQIP) database. OBJECTIVE: To determine the postoperative morbidity of one-level and two-level outpatient anterior cervical discectomy and fusion (ACDF) relative to inpatient cases, and risk factors for post-discharge complications. SUMMARY OF BACKGROUND DATA: ACDF is increasingly performed as an outpatient procedure, with evidence demonstrating outpatient one-level ACDF to be associated with fewer postoperative complications than inpatients...
November 18, 2016: Spine
https://www.readbyqxmd.com/read/27869243/personal-risk-factors-for-carpal-tunnel-syndrome-in-female-visual-display-unit-workers
#13
Matteo Riccò, Silvia Cattani, Carlo Signorelli
OBJECTIVES: Carpal tunnel syndrome (CTS) is the most common nerve entrapment syndrome, which since the beginning of the seventies has been linked to the keyboard and visual display unit (VDU). The objective of this study was to investigate the prevalence and personal factors associated with CTS in female VDU workers in Italy. MATERIAL AND METHODS: Participants in this study were female adult subjects, working ≥ 20 h/week (N = 631, mean age 38.14±7.81 years, mean working age 12...
November 18, 2016: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/27864932/hpv-status-and-favorable-outcome-in-vulvar-squamous-cancer
#14
Katie Wakeham, Kim Kavanagh, Kate Cuschieri, David Millan, Kevin G Pollock, Sarah Bell, Kevin Burton, Nicholas S Reed, Sheila V Graham
It is universally accepted that high-risk human papillomavirus (HR-HPV) is the cause of cervical dysplasia and cancer. More recently it has been shown that HPV is also a marker of clinical outcome in oropharyngeal cancer. However, contemporary information is lacking on both the prevalence of HPV infection in vulvar cancer (VSCC), its precursor lesion, vulvar intraepithelial neoplasia (VIN) and the influence of HPV-status on the prognosis of this malignancy. We have conducted a detailed population-based study to examine rates of progression of VIN to VSCC, type-specific HPV prevalence in vulvar disease and the influence of HPV status on clinical outcome in VSCC...
November 16, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27862677/effect-of-number-of-retrieved-lymph-nodes-on-prognosis-in-figo-stage-ib-iia-cervical-cancer-patients-treated-with-primary-radical-surgery
#15
Soyi Lim, Kyungjoo Cho, Seungho Lee, Kwangbeom Lee, Jinwoo Shin, Donghae Chung, Chanyong Park
AIM: In the treatment of cervical cancer, the extent of lymphadenectomy is a matter of debate. The goal of the current study was to examine the question of whether the number of retrieved lymph nodes (RLN) can influence survival of patients with early stage cervical cancer. METHODS: The medical records of 180 FIGO stage IB-IIA cervical cancer patients treated with primary radical surgery were reviewed. Patients were divided into two groups: those with ≤ 40 RLN and those with > 40 RLN...
November 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27854558/the-association-between-unwanted-sexual-experiences-and-early-onset-cervical-cancer-and-precancer-by-age-25-a-case-control-study
#16
Yasmin Leela Jayasinghe, Victoria Sasongko, Rachel Wenrui Lim, Sonia Regina Grover, Sepehr N Tabrizi, Elya E Moore, Susan Donath, Suzanne Marie Garland
BACKGROUND: We examined the association between unwanted sexual experiences and cervical cancer, cervical intraepithelial neoplasia 3, adenocarcinoma in situ, diagnosed ≤25 years of age. METHODS: A case-control study of women ≤55 years who attended gynecological hospitals in Australia between 1983 and 2007. Cases were ≤25 years when diagnosed with disease, control group 1 were "older women" >25 years at diagnosis; control group 2 were "well women" ≤25 years attending preventive health clinics...
November 17, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27854539/breast-and-cervical-cancer-screening-literacy-among-korean-american-women-a-community-health-worker-led-intervention
#17
Hae-Ra Han, Youngshin Song, Miyong Kim, Haley K Hedlin, Kyounghae Kim, Hochang Ben Lee, Debra Roter
OBJECTIVES: To test a community health worker (CHW)-led health literacy intervention on mammogram and Papanicolaou test screening among Korean American women. METHODS: We conducted a cluster-randomized trial at 23 ethnic churches in the Baltimore, Maryland-Washington, DC, metropolitan area between 2010 and 2014. Trained CHWs enrolled 560 women. The intervention group received an individually tailored cancer-screening brochure followed by CHW-led health literacy training and monthly telephone counseling with navigation assistance...
November 17, 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27852183/trends-in-cancer-incidence-and-survival-for-indigenous-and-non-indigenous-people-in-the-northern-territory
#18
John R Condon, Xiaohua Zhang, Karen Dempsey, Lindy Garling, Steven Guthridge
OBJECTIVE: To assess trends in cancer incidence and survival for Indigenous and non-Indigenous Australians in the Northern Territory. DESIGN: Retrospective analysis of population-based cancer registration data. SETTING: New cancer diagnoses in the NT, 1991-2012. MAIN OUTCOME MEASURES: Age-adjusted incidence rates; rate ratios comparing incidence in NT Indigenous and non-Indigenous populations with that for other Australians; 5-year survival; multivariable Poisson regression of excess mortality...
November 21, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27843328/cervical-nodal-necrosis-is-an-independent-survival-predictor-in-nasopharyngeal-carcinoma-an-observational-cohort-study
#19
Yangkun Luo, Jing Ren, Peng Zhou, Yang Gao, Guangquan Yang, Jinyi Lang
PURPOSE: Most nasopharyngeal carcinoma (NPC) patients present with locoregionally advanced disease at the time of diagnosis; however, there is a lack of consensus on specific prognostic factors potentially improving overall survival, especially in late-stage disease. Herein, we conducted a retrospective study to evaluate various potential prognostic factors in order to provide useful information for clinical treatment of T3/T4-stage NPC. PATIENTS AND METHODS: A total of 189 previously untreated NPC patients were enrolled in the current study...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27836494/associations-between-vaginal-infections-and-potential-high-risk-and-high-risk-human-papillomavirus-genotypes-in-female-sex-workers-in-western-kenya
#20
Sonia Menon, Davy Vanden Broeck, Rodolfo Rossi, Emiliono Ogbe, Stacy Harmon, Hillary Mabeya
PURPOSE: Infection with and persistence of high-risk human papillomavirus (HR HPV) are the strongest risk factors for cervical cancer. Little is known about the prevalence and role of concurrent sexually transmitted infections (STIs) found in HPV-infected female sex workers (FSW) in Africa. This study purports to test our a priori hypotheses that STIs are associated with genotypes pertaining to the α-group species 9. The objectives were to determine the prevalence of bacterial vaginosis (BV), Trichomonas vaginalis, and Candida spp in FSW, the association between these STIs and the prevalence of any potential HR and HR HPV genotypes in FSWs...
November 8, 2016: Clinical Therapeutics
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