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Cervical Adjustments

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https://www.readbyqxmd.com/read/29681462/the-onclarity-human-papillomavirus-trial-design-methods-and-baseline-results
#1
Mark H Stoler, Thomas C Wright, Valentin Parvu, Laurence Vaughan, Karen Yanson, Karen Eckert, Tobi Karchmer, Salma Kodsi, Charles K Cooper
OBJECTIVES: The baseline phase of the Onclarity trial was conducted to determine the screening performance of the Onclarity human papillomavirus (HPV) assay for detecting cervical cancer and precancer (≥CIN2) during triage of women ≥21 years with ASC-US cytology, as an adjunct test in women ≥30 years with normal cytology and for primary screening (HPV alone) in women ≥25 years. METHODS: 33,858 women ≥21 years were enrolled during routine clinic visits...
April 19, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29673740/recent-intrauterine-device-use-and-the-risk-of-precancerous-cervical-lesions-and-cervical-cancer
#2
Sarah Averbach, Michael J Silverberg, Wendy Leyden, Karen Smith-McCune, Tina Raine-Bennett, George F Sawaya
OBJECTIVE: Understanding the effect of contraceptives on the development of precancerous lesions of the cervix and cervical cancer may provide information that is valuable to women in contraceptive decision-making. The purpose of this study was to evaluate the association between recent intrauterine device (IUD) use (by type) and cervical intraepithelial neoplasia 2, 3, adenocarcinoma in situ or cancer (CIN2+ or CIN3+). STUDY DESIGN: Case-control study of 17,559 women age 18-49 with incident CIN2+ cases and 5:1 age-matched, incidence-density selected controls (N=87,378) who were members of Kaiser Permanente Northern California Healthcare System from 1996-2014...
April 16, 2018: Contraception
https://www.readbyqxmd.com/read/29664764/epstein-barr-virus-high-risk-human-papillomavirus-and-abnormal-cervical-cytology-in-a-prospective-cohort-of-african-female-sex-workers
#3
Jennifer E Cameron, Anne F Rositch, Nadja A Vielot, Nelly R Mugo, Jessie K L Kwatampora, Wairimu Waweru, Aubrey E Gilliland, Michael E Hagensee, Jennifer S Smith
BACKGROUND: High oncogenic-risk human papillomavirus (hrHPV) is necessary, although insufficient, to promote cervical cancer. Like HPV, Epstein-Barr virus (EBV) is a common pathogen with the capacity to promote epithelial neoplasms. We examined the association between cervical EBV, hrHPV, and cytology in female sex workers in Nairobi, Kenya. METHODS: Women (n=332) with known cervical cytology and hrHPV mRNA results were evaluated for cervical EBV DNA by conventional PCR...
April 17, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29661220/asymmetrical-degenerative-marrow-modic-changes-in-cervical-spine-prevalence-correlative-factors-and-surgical-outcomes
#4
Xianda Gao, Jia Li, Yiqing Shi, Shaoqing Li, Yong Shen
BACKGROUND: The current study aimed to discuss the prevalence and surgical outcomes of the asymmetrical Modic changes and identify its correlative factors by multivariate logistic regression analysis. METHODS: Two hundred seventy-eight patients with single-level Modic changes and nerve compression symptoms were reviewed retrospectively from January 2008 to January 2015. 1.5-T MRI was performed to determine the Modic changes. Multivariate logistic regression analysis was used to identify the correlative factors of asymmetrical Modic changes...
April 16, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29660208/mir-340-suppresses-the-metastasis-by-targeting-epha3-in-cervical-cancer
#5
Hemei Xiao, Lijie Yu, Fengdan Li, Haili Wang, Wenxiu Li, Xinxia He
MicroRNAs (miRNAs ) play key roles in cervical cancer metastasis progression. Accumulated evidences have revealed that miRNAs are related to the pathophysiological process. However, the role of miR-340 in cervical cancer and how it works is still not fully interpreted. Using qRT-PCR to examine the expression of miR-340 in cervical cancer tissues. Transwell migration and invasion experiments were used to detect the role of miR-340 in migration and invasion. Luciferase reporter assay, qRT-PCR and Western blot were used to detect the relationship between miR-340 and EphA3...
April 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29650001/prediction-of-autonomic-dysreflexia-during-urodynamics-a-prospective-cohort-study
#6
Matthias Walter, Stephanie C Knüpfer, Jacquelyn J Cragg, Lorenz Leitner, Marc P Schneider, Ulrich Mehnert, Andrei V Krassioukov, Martin Schubert, Armin Curt, Thomas M Kessler
BACKGROUND: Autonomic dysreflexia is a severe and potentially life-threatening condition in patients with spinal cord injury, as it can lead to myocardial ischemia, brain hemorrhage, or even death. Urodynamic investigation is the gold standard to assess neurogenic lower urinary tract dysfunction due to spinal cord injury and reveal crucial pathological findings, such as neurogenic detrusor overactivity. However, neurogenic detrusor overactivity and urodynamic investigation are known to be leading triggers of autonomic dysreflexia...
April 13, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29649609/surgical-treatment-improves-survival-of-elderly-with-axis-fracture-a-national-population-based-multi-registry-cohort-study
#7
Anna-Lena Robinson, Claes Olerud, Yohan Robinson
Background Context Fractures of the axis (C2) are the most common cervical spinal injuries in the elderly population. Several authors have reported improved survival among elderly patients with C2 fractures when treated surgically. Purpose To analyze whether surgery improves survival of elderly with C2 fractures. Study Design/ Setting Observational population-based longitudinal multi-registry study Patient Sample Swedish Patient Registry 1997 to 2014, and Swedish Cause of Death Registry 1997 to 2014 Outcome measures Survival after C2 fracture according to non-surgical and surgical treatment...
April 9, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29649025/risk-of-anal-cancer-in-women-with-a-human-papillomavirus-related-gynecological-neoplasm-puerto-rico-1987-2013
#8
Adrianna I Acevedo-Fontánez, Erick Suárez, Carlos R Torres Cintrón, Ana P Ortiz
OBJECTIVE: The aim of the study was to estimate the magnitude of the association between HPV-related gynecological neoplasms and secondary anal cancer among women in Puerto Rico (PR). MATERIALS AND METHODS: We identified 9,489 women who had been diagnosed with a primary cervical, vaginal, or vulvar tumor during 1987-2013. To describe the trends of invasive cervical, vulvar, vaginal, and anal cancer, the age-adjusted incidence rates were estimated using the direct method (2000 US as Standard Population)...
April 11, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29630020/disparities-in-adherence-to-national-comprehensive-cancer-network-treatment-guidelines-and-survival-for-stage-ib-iia-cervical-cancer-in-california
#9
Krista S Pfaendler, Jenny Chang, Argyrios Ziogas, Robert E Bristow, Kristine R Penner
OBJECTIVE: To evaluate the association of sociodemographic and hospital characteristics with adherence to National Comprehensive Cancer Network treatment guidelines for stage IB-IIA cervical cancer and to analyze the relationship between adherent care and survival. METHODS: This is a retrospective population-based cohort study of patients with stage IB-IIA invasive cervical cancer reported to the California Cancer Registry from January 1, 1995, through December 31, 2009...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29628012/blunt-pharyngoesophageal-injuries-current-management-strategies
#10
G Barmparas, P H Navsaria, D Serna-Gallegos, A J Nicol, S Edu, A A Sayari, D R Margulies, E J Ley
BACKGROUND: Blunt pharyngoesophageal injuries pose a management challenge to the trauma surgeon. The purpose of this study was to explore whether these injuries can be managed expectantly without neck exploration. METHODS: The National Trauma Databank datasets 2007-2011 were reviewed for blunt trauma patients who sustained a pharyngeal injury, including an injury to the cervical esophagus. Patients who survived over 24 h and were not transferred from other institutions were divided into two groups based on whether a neck exploration was performed...
April 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29617952/risk-factors-for-human-papillomavirus-infection-and-abnormal-cervical-cytology-among-perinatally-human-immunodeficiency-virus-infected-and-uninfected-asian-youth
#11
Annette H Sohn, Stephen J Kerr, Rawiwan Hansudewechakul, Sivaporn Gatechompol, Kulkanya Chokephaibulkit, Hanh Le Dung Dang, Dan Ngoc Hanh Tran, Jullapong Achalapong, Nipat Teeratakulpisarn, Amphan Chalermchockcharoenkit, Manopchai Thamkhantho, Tippawan Pankam, Thida Singtoroj, Wichai Termrungruanglert, Surasith Chaithongwongwatthana, Nittaya Phanuphak
Background: Infection with high-risk human papillomavirus (HR-HPV) may be higher in perinatally human immunodeficiency virus (HIV)-infected (PHIV) than HIV-uninfected (HU) adolescents because of long-standing immune deficiency. Methods: PHIV and HU females aged 12-24 years in Thailand and Vietnam were matched by age group and lifetime sexual partners. At enrollment, blood, cervical, vaginal, anal, and oral samples were obtained for HPV-related testing. The Wilcoxon and Fisher exact tests were used for univariate and logistic regression for multivariate analyses...
March 30, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29610007/conventional-joa-score-for-cervical-myelopathy-has-a-rater-s-bias-in-comparison-with-joacmeq
#12
Noboru Hosono, Shota Takenaka, Yoshihiro Mukai, Kosuke Tateishi, Yasushi Fujiwara, Yuichiro Morishita, Hiroaki Konishi
BACKGROUND: The JOA (Japan Orthopaedic Association) score has been a standard outcome measure to evaluate cervical myelopathy in Japan. Despite its reliability and convenience, there can be a rating bias in the JOA score. The current study was conducted to delineate the rater's bias of the JOA score by comparing it with a new objective outcome measure. METHODS: Two hundred and thirty four operative candidates with cervical myelopathy were included in the study. The patients were divided into four groups according to the surgeon (92 patients in group A, 60 patients in group B, 38 patients in group C and 44 patients in group D)...
March 30, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29605052/the-impact-of-nativity-on-cervical-cancer-survival-in-the-public-hospital-system-of-queens-new-york
#13
George S Hagopian, Molly Lieber, Peter R Dottino, M Margaret Kemeny, Xilian Li, Jessica Overbey, Li-Duen Clark, Ann Marie Beddoe
OBJECTIVE: We studied cervical cancer patients who presented to the Public Hospital System in ethnically-diverse Queens, New York from 2000 to 2010 with the purpose of examining the relationship between nativity (birthplace) and survival. METHODS: A retrospective review of tumor registries was used to identify patients diagnosed with cervical cancer between January 1, 2000 and December 31, 2010. Using electronic medical records, data from 317 patients were available for this analysis...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29603036/is-elevated-body-mass-index-protective-against-cervical-spine-injury-in-adults
#14
Nicholas M Beckmann, Chunyan Cai, Susanna C Spence, Mark L Prasarn, O Clark West
PURPOSE: Correlate body mass index (BMI) with incidence and type of cervical spine injury seen on CT in adult patients presenting with blunt trauma. MATERIALS AND METHODS: Retrospective chart review of all adult blunt trauma patients who had a cervical spine CT performed at our level 1 trauma center during an approximately 3-year period. RESULTS: A statistically significant (p = 0.01) difference in cervical spine injury incidence was present between different BMI groups...
March 30, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29596907/urban-rural-inequities-in-the-parental-attitudes-and-beliefs-towards-human-papillomavirus-infection-cervical-cancer-and-hpv-vaccine-in-mysore-india
#15
Abraham Degarege, Karl Krupp, Kristopher Fennie, Tan Li, Dionne P Stephens, Laura A V Marlow, Vijaya Srinivas, Anjali Arun, Purnima Madhivanan
OBJECTIVE: The aim of this study was to compare the parental attitudes and beliefs about HPV, cervical cancer and HPV vaccine between urban and rural areas, India. DESIGN: Cross sectional SETTING: Mysore, India PARTICIPANTS: Parents of school going adolescent girls INTERVENTION: Parents completed a self-administered questionnaire MAIN OUTCOME MEASURES: : Attitudes and beliefs about HPV, cervical cancer and HPV vaccine RESULTS: A total of 1609 parents from urban (n=778) and rural (n=831) areas participated in this study...
March 26, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29594218/the-predictive-value-of-nadir-neutrophil-count-during-treatment-of-cervical-cancer-interactions-with-tumor-hypoxia-and-interstitial-fluid-pressure-ifp
#16
Rachel Glicksman, Naz Chaudary, Melania Pintilie, Eric Leung, Blaise Clarke, Kieyan Sy, Richard P Hill, Kathy Han, Anthony Fyles, Michael Milosevic
Background and purpose: Hypoxia, high interstitial fluid pressure (IFP) and immune effects have individually been shown to modulate radiotherapy (RT) response in cervical cancer. The aim of this study was to investigate the interplay between hypoxia or IFP and circulating neutrophil levels, and their combined effect on survival following RT. Material and methods: A total of 287 FIGO stage IB to IIIB cervical cancer patients treated with RT or RT and cisplatin (RTCT) were included...
October 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29587796/human-papilloma-virus-correlates-of-high-grade-cervical-dysplasia-in-hiv-infected-women-in-mombasa-kenya-a-cross-sectional-analysis
#17
Sonia Menon, Stanley Luchters, Rodolfo Rossi, Steven Callens, Mandaliya Kishor, Johannes Bogers, Davy Vanden Broeck
BACKGROUND: Women living with HIV are at increased risk to be co-infected with HPV, persistent high-risk (HR) human papillomavirus (HPV) infection and increased HR HPV viral load, which make them more at risk for cervical cancer. Despite their inherent vulnerability, there is a scarcity of data on potential high risk (pHR) and HR HPV genotypes in HIV- infected women with cervical dysplasia and HPV-type specific viral load in this population in Sub Saharan Africa. The aim of this analysis of HIV-infected women was to explore the virological correlates of high-grade cervical dysplasia (CIN 2+) in HIV-infected women, thereby profiling HPV genotypes...
March 27, 2018: Virology Journal
https://www.readbyqxmd.com/read/29587400/association-between-cervical-spondylosis-and-migraine-a-nationwide-retrospective-cohort-study
#18
Wang-Sheng Lin, Tung-Fu Huang, Tien-Yow Chuang, Cheng-Li Lin, Chia-Hung Kao
Background: Few studies have investigated the longitudinal association between cervical spondylosis (CS) and migraine by using a nationwide population-based database. Methods: We conducted a retrospective cohort study from 2000 to 2011 identifying 27,930 cases of cervical spondylosis and 111,720 control subjects (those without cervical spondylosis) from a single database. The subjects were frequency-matched on the basis of sex, age, and diagnosis date. The non- cervical spondylosis cohort was four times the size of the cervical spondylosis cohort...
March 25, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29584506/ais-scores-in-spine-and-spinal-cord-trauma-epidemiological-considerations
#19
Dennis Maiman, Frank Pintar, Waqar Malik, Narayan Yoganandan
BACKGROUND: The Abbreviated Injury Scale (AIS) is an internationally accepted coding system created by the Association for the Advancement of Automotive Medicine, utilized to code traumatic injuries as a function of severity, the latter often defined as mortality risk. Periodic reassessment of that risk is prudent, in light of advances in health care and relationship of nonanatomic factors to death. OBJECTIVE: The objective of this study was to reevaluate the risk of death associated with spine fractures with and without neurologic deficit, age factors associated with it, and the impact of hospital coding on the accuracy of these efforts...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29583084/the-effect-of-cervical-smears-performed-by-general-practitioners-on-the-cervical-cancer-screening-rate-of-their-female-patients-a-claim-database-analysis-and-cross-sectional-survey
#20
Jonathan Favre, Michaël Rochoy, Thibaut Raginel, Marine Pelletier, Nassir Messaadi, Valérie Deken-Delannoy, Alain Duhamel, Christophe Berkhout
PURPOSE: Cervical cancer screening reduces the incidence and specific mortality rate of cervical neoplasms. In most cases screening by means of Pap smears is performed in France by gynecologists. The primary objective of this study was to confirm whether the participation rate is increased when general practitioners (GPs) carry out the smears themselves. The secondary objective was to evaluate other independent characteristics of GPs predicting participation rates in women. METHODS: The population of 347 GPs, including their relevant characteristics and their 90,094 female patients eligible for screening over 2 years (2013-2014), was derived from the SIAM claim database of the Flanders Healthcare Insurance Fund (CPAM)...
March 27, 2018: Journal of Women's Health
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