Min Chen, Dafeng Yang, Yangzhao Zhou, Chongzhe Yang, Wenhui Lin, Jie Li, Jitao Liu, Jiamin Ye, Wenhui Huang, Wentao Ma, Wei Li, Jiyan Chen, Ying Zhang, Guo-Ping Shi, Jianfang Luo, Jie Li, Songyuan Luo
Development of non-surgical treatment of human abdominal aortic aneurysm (AAA) has clinical significance. Colchicine emerges as an effective therapeutic regimen in cardiovascular diseases. Yet, whether colchicine slows AAA growth remain controversy. Here, we demonstrated that daily intragastric administration of low-dose colchicine blocked AAA formation, prevented vascular smooth muscle cell (SMC) phenotype switching and apoptosis, and vascular inflammation in both peri-aortic CaPO4 injury and subcutaneous angiotensin-II infusion induced experimental AAA mice models...
2024: International Journal of Biological Sciences