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MUSCLE INJURIE

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https://www.readbyqxmd.com/read/29777951/experimental-referred-pain-extends-towards-previously-injured-location-an-explorative-study
#1
Thorvaldur Skuli Palsson, Shellie A Boudreau, Hans Jørgen Krebs, Thomas Graven-Nielsen
Facilitated pain mechanisms have been demonstrated in musculoskeletal pain but it is unclear whether a recent painful injury leaves the pain system sensitized. Pain characteristics were assessed in individuals who recently recovered from ankle pain (recovered pain group; n=25) and sex-matched controls (n=25) in response to tonic-pressure pain and saline-induced pain applied at the shin muscle. Pain intensity and pain referral patterns were recorded bilaterally after the painful muscle stimulus. Pressure pain thresholds (PPTs) were measured at the lower legs and shoulder...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29777277/impact-of-muscle-atrophy-on-bone-metabolism-and-bone-strength-implications-for-muscle-bone-crosstalk-with-aging-and-disuse
#2
REVIEW
T Bettis, B-J Kim, M W Hamrick
Bone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to microgravity is also preceded by a rapid loss of muscle mass. Recent studies using animal models in the setting of hindlimb unloading or botulinum toxin (Botox) injection also reveal that muscle loss can induce bone loss. Moreover, muscle-derived factors such as irisin and leptin can inhibit bone loss with unloading, and knockout of catabolic factors in muscle such as the ubiquitin ligase Murf1 or the myokine myostatin can reduce osteoclastogenesis...
May 18, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29776846/moderators-of-angiogenesis-in-muscle-flaps-a-non-randomised-animal-study
#3
Kimberley Bradshaw, Michael Wagels
INTRODUCTION: A muscle flap can survive a pedicle injury under favourable conditions. In the reconstruction of compound limb injuries, the wound milieu is variable and may affect the rate and manner of neovascularisation. Our aim is to determine the effect of some key clinical variables on neovascularisation in muscle flaps in an animal model. METHODOLOGY: The pectoralis profundus was raised in 60 rats and covered with a skin graft. Fifteen rats were allocated to each of the following groups: separation of the flap from the skin inset (S), inflammation by inoculation with Staphylococcus aureus (I), flap elevation with harmonic scalpel (H) and preservation of the motor nerve (N) as well as compared to controls (C)...
April 23, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29775802/nonoperative-management-of-a-severe-proximal-rectus-femoris-musculotendinous-injury-in-a-recreational-athlete-a-case-report
#4
Park Ck, Zlomislic V, Du J, Huang Bk, Chang Ey, Chang Dg
This report describes a severe injury to the proximal rectus femoris (RF) muscle in a 37-year-old recreational athlete. This injury is a relatively rare occurrence in both the general and elite athletic populations. Acute and long-term imaging and functional outcomes are described. This athlete was able to return to full activity without surgical intervention. Follow-up imaging demonstrated gross healing of both complete (or near complete) muscle and tendon tears.
May 15, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29774991/aggregate-mesenchymal-stem-cell-delivery-ameliorates-the-regenerative-niche-for-muscle-repair
#5
Marissa A Ruehle, Hazel Y Stevens, Aaron M Beedle, Robert E Guldberg, Jarrod A Call
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease due to the absence of the dystrophin protein from the muscle cell membrane which renders the muscle susceptible to continuous damage. In DMD patients, muscle weakness, together with cycles of degeneration/regeneration and replacement with non-contractile tissue, limit mobility and lifespan. Since the loss of dystrophin result in loss of polarity and a reduction in the number of self-renewing satellite cells, it is postulated that these patients could achieve an improved quality of life if delivered cells could restore satellite cell function...
May 18, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29774825/dietary-zinc-modulates-matrix-metalloproteinases-in-traumatic-brain-injury
#6
Angus Scrimgeour, Christopher Carrigan, Michelle Lynn Condlin, Maria L Urso, Roland M van den Berg, Herman P M van Helden, Scott J Montain, Marloes J A Joosen
Animal models of mild traumatic brain injury (mTBI) provide opportunity to examine the extent to which dietary interventions can be used to improve recovery after injury. Animal studies also suggest that matrix metalloproteinases (MMPs) play a role in tissue remodeling post-TBI. Because dietary zinc (Zn) improved recovery in non-blast mTBI models, and the MMPs are Zn-requiring enzymes, we evaluated the effects of low- and adequate Zn diets on MMP expression and behavioral responses, following exposure to a single blast...
May 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29774231/semaphorin3a-signaling-is-dispensable-for-motor-axon-reinnervation-of-the-adult-neuromuscular-junction
#7
Jennifer L Shadrach, Brian A Pierchala
The neuromuscular junction (NMJ) is a specialized synapse that is formed by motor axon innervation of skeletal muscle fibers. The maintenance of motor-muscle connectivity is critical for the preservation of muscle tone and generation of movement. Injury can induce a robust regenerative response in motor axons, but severe trauma or chronic denervation resulting from neurodegenerative disease typically leads to inefficient repair and poor functional recovery. The axon guidance molecule Semaphorin3A (Sema3A) has been implicated as a negative regulator of motor innervation...
May 2018: ENeuro
https://www.readbyqxmd.com/read/29773764/degloving-lower-leg-injury-the-importance-of-additional-treatment-negative-pressure-and-hyperbaric-oxygen-therapy
#8
Piotr Stabryła, Joanna Kulińska, Łukasz Warchoł, Anna Kasielska-Trojan, Wojciech Gaszyński, Bogusław Antoszewski
Degloving injury poses a severe therapeutic challenge concerning both trauma and plastic surgery. The injury involves separation of skin and subcutaneous tissue from fascia and muscles. Treatment is often long-lasting and brings unsatisfying results due to the extent of damage, risk of infection and massive blood loss. In this article, we present the management and therapeutic outcomes of a patient admitted due to the degloving injury of the lower extremity caused by workplace accident. We described the complexity of treatment including surgical intervention as well as additional treatment, which combined brought good esthetic outcome...
April 30, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29773514/association-between-trunk-muscles-characteristics-with-lower-limb-injuries-a-systematic-review
#9
REVIEW
M Emami, M A Mohseni Bandpei, N Rahmani, A Biglarian, M Taghipour
No abstract text is available yet for this article.
April 22, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29772412/tactile-cues-can-change-movement-an-example-using-tape-to-redistribute-flexion-from-the-lumbar-spine-to-the-hips-and-knees-during-lifting
#10
Brendan L Pinto, Shawn M Beaudette, Stephen H M Brown
Given the appropriate cues, kinematic factors associated with low back injury risk and pain, such as spine flexion, can be avoided. Recent research has demonstrated the potential for tactile sensory information to change movement. In this study an athletic strapping tape was applied bilaterally along the lumbar extensor muscles to provide continuous tactile feedback information during a repeated lifting and lowering task. The presence of the tape resulted in a statistically significant reduction in lumbar spine flexion when compared to a baseline condition in which no tape was present...
May 14, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29772187/platelet-rich-plasma-releasate-promotes-regeneration-and-decreases-inflammation-and-apoptosis-of-injured-skeletal-muscle
#11
Wen-Chung Tsai, Tung-Yang Yu, Gwo-Jyh Chang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S Pang
BACKGROUND: Platelet-rich plasma (PRP) contains various cytokines and growth factors that may be beneficial to the healing process of injured muscle. Based on the authors' previous study, PRP releasate can promote proliferation and migration of skeletal muscle cells in vitro, so animal studies are performed to support the use of PRP to treat muscle injury in vivo. PURPOSE: To investigate the effect of PRP releasate on regeneration of injured muscle, as well as its effect on inflammatory reaction and cell apoptosis, in the early stages of the muscle-healing process...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29771627/efficiency-and-perceived-exertion-of-novel-wheelchair-wheels-a-comparative-study
#12
Laura Sanches Rocha, Bonita Sawatzky, W Ben Mortenson
New geared wheelchair wheels have been developed allowing the user to pull backwards on the rims to move forward. Theoretically, this utilizes larger muscle groups compared to conventional propulsion preventing repetitive stress injuries. This study compared the gross mechanical efficiency (GME), perceived effort and energy expenditure of propelling the wheelchair using two types of these geared wheels and standard forward propulsion wheels. A within participants repeated measures design was used. Participants' energy expenditure and perceived exertion were measured...
May 17, 2018: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/29771608/paced-breathing-and-phrenic-nerve-responses-evoked-by-epidural-stimulation-following-complete-high-cervical-spinal-cord-injury-in-rats
#13
Tatiana Bezdudnaya, Michael A Lane, Vitaliy Marchenko
Spinal cord injury (SCI) at the level of cervical segments often results in life-threatening respiratory complications and requires long-term mechanical ventilator assistance. Thus, restoring diaphragm activity and regaining voluntary control of breathing are the primary clinical goals for patients with respiratory dysfunction following cervical SCI. Epidural stimulation (EDS) is a promising strategy that has been explored extensively for non-respiratory functions, and to a limited extent within the respiratory system...
May 17, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29771606/improved-motor-unit-number-estimate-when-motor-unit-alternation-is-addressed
#14
Bradley A DeForest, Jeffrey Winslow, Christine K Thomas
Motor unit number estimation (MUNE) is important for determining motoneuron survival with age or in conditions such as amyotrophic lateral sclerosis or spinal cord injury. The original incremental method, or approaches introduced to minimize alternation (e.g. multiple point stimulation), are most commonly used but accept the limitation that alternation of motor units may still inflate the estimate. Alternation occurs because axon thresholds are probabilistic and overlap for different axons, therefore different combination of motor units may respond at a given stimulus intensity...
May 17, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29771357/a-promotive-effect-for-halofuginone-on-membrane-repair-and-synaptotagmin-7-levels-in-muscle-cells-of-dysferlin-null-mice
#15
Hila Barzilai-Tutsch, Melissa Dewulf, Christophe Lamaze, Gillian Butler Browne, Mark Pines, Orna Halevy
In the absence of dysferlin, skeletal muscle cells fail to reseal properly after injury, resulting in slow progress of the dysferlinopathy muscular dystrophy. Halofuginone, a leading agent in preventing fibrosis in muscular dystrophies, was tested for its effects on membrane resealing post-injury. A hypo-osmotic shock assay on myotubes derived from wild-type and dysferlin-null (dysf-/-) mice revealed that pre-treatment with halofuginone reduces the percentage of membrane-ruptured myotubes only in dysf-/- myotubes...
May 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29771121/effects-of-geniposide-from-gardenia-fruit-pomace-on-skeletal-muscle-fibrosis
#16
Haiou Pan, Yan Li, Hai Feng Qian, Xiguang Qi, Gangcheng Wu, Hui Zhang, Meijuan Xu, Zhiming Rao, Jinlong Li, Li Wang, Hao Ying
Geniposide is the main bioactive constituent of Gardenia fruit. Skeletal muscle fibrosis is a common and irreversible damage process. Numerous studies have shown that geniposide could improve many chronic diseases including metabolic syndrome and tumor. However, the effects of geniposide on skeletal muscle fibrosis are still poorly understood. Here, we found that crude extracts from Gardenia fruit pomace could significantly decrease the expressions of pro-fibrotic genes in vitro. Moreover, geniposide could also reverse pro-fibrotic gene expression induced by TGF- and Smad4, a regulator of skeletal muscle fibrosis...
May 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29769834/continuous-knee-cooling-affects-functional-hop-performance-a-randomized-controlled-trial
#17
Bruno Tassignon, Ben Serrien, Kevin De Pauw, Jean-Pierre Baeyens, Romain Meeusen
Cryotherapy is widely used in sports and rehabilitation to aid recovery and injury management. The purpose was to examine if a low temperature computer controlled continuous knee cooling protocol (10°C) for one hour and a moderate continuous knee cooling protocol (18°C) for one hour affected neuromuscular activity and functional performance tests. We used a randomized controlled study design. Twenty healthy male subjects (age = 24 ± 3 years) were included and randomized into 2 groups (10°C and 18°C). On day one, participants performed a maximal voluntary contraction of the quadriceps (MVC), single leg hop for distance (SLHD), and crossover hop for time (COHT) with both legs before and after cooling of their right leg...
June 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29768313/the-incidence-of-myocardial-injury-after-loading-doses-of-clopidogrel-versus-prasugrel-in-the-candidates-for-percutaneous-coronary-intervention-a-randomized-controlled-trial
#18
Reza Rahmani, Laya Jiriaee, Zahra Jiriaee, Akbar Shafiee, Amir Farhang Zand Parsa
INTRODUCTION: Prevention of myocardial injury is an essential issue in percutaneous coronary intervention (PCI). We compared the incidence of myocardial injury after loading doses of clopidogrel versus prasugrel in the candidates for PCI. METHODS: In this randomized-controlled clinical trial, we enrolled 88 stable angina patients, candidate for PCI. Patients received either prasugrel (60 mg orally) (n = 42) or clopidogrel (600 mg orally) (n = 46). Serum levels of creatine phosphokinase muscle-brain type, cardiac troponin I, and high sensitive C-reactive protein were measured at baseline and 6 and 12 hours postprocedural...
June 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29767451/feline-ureteral-obstructions-part-1-medical-management
#19
REVIEW
D L Clarke
Feline ureteral obstructions are an increasingly recognised and challenging diagnostic and management problem. Many cats with ureteral obstructions are critically ill at the time of diagnosis, especially if there is dysfunction of the contralateral kidney. They may present with varying severities of acute kidney injury, electrolyte disturbances, and may have comorbidities such as heart disease that complicate perioperative and long-term management. Medical management, which may consist of rehydration and restoration of intravascular volume with intravenous fluid therapy, osmotic diuresis, ureteral muscle relaxation, and antimicrobials for infection, is important in feline ureteral obstruction patients...
May 16, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29767228/whiplash-injury-results-in-sustained-impairments-of-cervical-muscle-function-a-one-year-prospective-controlled-study
#20
Søren Krogh, Helge Kasch
OBJECTIVE: To investigate the temporal development of neck muscle function following whiplash injuries. DESIGN: A 1-year prospective, controlled observational study. SUBJECTS: A total of 141 individuals exposed to whiplash injury due to rear-end vehicle collisions and 40 age- and sex-matched controls with acute ankle distortion. METHODS: Neck muscle strength and endurance during cervical flexion and extension were measured at 1 week, 1 month, 3 months, 6 months and 1 year after injury...
May 16, 2018: Journal of Rehabilitation Medicine
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