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Cheramadathukudiyil Skaria Paulose, Ponnezhathu Sebastian John, Romeo Chinthu, Puthenveetil Raju Akhilraj, Thoppil Raveendran Anju
BACKGROUND: Spinal cord injury results in disruption of brain-spinal cord fibre connectivity, leading to progressive tissue damage at the site of injury and resultant paralysis of varying degrees. The current study investigated the role of autologous bone marrow modulated with neurotransmitters and neurotransmitter stimulating agent, Citicholine, in spinal cord of spinal cord injured rats. METHODS: Radioreceptor assay using [3H] ligand was carried out to quantify muscarinic receptor...
April 2017: Biomedical Journal
Sam D Perez, Kristy Du, Catarina Rendeiro, Lin Wang, Qian Wu, Stanislav S Rubakhin, Rema Vazhappilly, Jeffrey H Baxter, Jonathan V Sweedler, Justin S Rhodes
It is widely believed that diet can influence the onset and severity of cognitive aging, but the optimal combination of micronutrients and molecular and cellular mechanisms remain elusive. The purpose of this study was to compare the effects of eight distinct diets, consisting of various concentrations of selected micronutrients, on learning and memory as well as markers of neuronal plasticity, and metabolic and neuro-immune status of the aged hippocampus. Eighteen-month-old male and female C57BL/6J mice were fed the diets for 16 weeks, followed by learning and memory trials on the active avoidance task...
March 1, 2017: Behavioural Brain Research
Saikat Ghosh, Somak Kumar Das, Tanusree Nath, Kartik Chandra Ghosh, Ramesh Bhattacharyya, Gouranga Prosad Mondal
BACKGROUND: Citicoline is a novel neuroprotective agent used in acute stroke with a significantly favorable outcome. MATERIALS AND METHODS: A hundred patients who suffered from either an ischemic and hemorrhagic stroke and who presented to the hospital within 48 h of stroke onset were enrolled for the study. Of these 100 patients (age- and sex-matched), 50 patients were treated with citicoline along with the standard stroke management and considered as 'cases'. The other 50 patients who were administered the standard stroke treatment were considered as 'controls...
September 2015: Neurology India
Jeffrey J Rakofsky, Boadie W Dunlop
Many patients view psychotropics with skepticism and fear and view nutritional supplements as more consistent with their values and beliefs. The purpose of this review was to critically evaluate the evidence base for nutritional supplements in the treatment of bipolar depression (BD). A literature search for all randomized, controlled clinical trials using nutritional supplements in the treatment of BD was conducted via PubMed and Ovid MEDLINE computerized database. The studies were organized into essential nutrients/minerals, nonessential nutrients, and combinations of nutritional products...
May 2014: Depression and Anxiety
N A Shamalov, L V Stakhovskaia, I M Shetova, N M Efremova, K V Anisimov
One hundred and four patients with acute carotid ischemic stroke were included in the study. Patients were divided into 4 groups. Patients of control group (group 1) were treated with equal basic and reperfusional therapy without any cytoprotectors. Patients of the 2nd group received citicholine in dose 1000 mg per day. Patients of the 3rd group were treated with 250 ml actovegin per day. The NIH stroke scale, the modified Rankin scale and the Barthel index were used to assess neurological status dynamics. The significant decrease of neurological deficit and improvement of functional recovery were seen in patients treated both with citicholine and actovegin (p < 0...
2010: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
V Sturm
Amblyopia is a condition of decreased monocular or binocular visual acuity caused by form deprivation or abnormal binocular interaction. Amblyopia is the most common cause of monocular vision loss in children with a prevalence of 2 to 5%. During the last decade, several prospective randomized studies have influenced our clinical management. Based on these studies, optimum refractive correction should be prescribed first. However, most patients will need additional occlusion therapy which is still considered the «gold standard» of amblyopia management...
February 16, 2011: Praxis
S Aaron, M Alexander, T Maya, V Mathew, M Goyal
For promptly referral of a patient with acute ischemic stroke (AIS) for possible thrombolysis, general practitioners (GPs) need to equipped with the advanced knowledge of AIS treatment. We assessed the knowledge regarding treatment of AIS among GPs practicing in and around a quaternary care teaching hospital in south India. A total of 109 GPs who attend to medical emergencies were interviewed using a standard questionnaire. Of the 109 GPs interviewed, 54% felt that tissue plasminogen activator (tPA) can be used in the treating AIS, but only 24% had chosen tPA as the best treatment option and 22% opted for other agents like citicholine or edavarone...
May 2010: Neurology India
Mine Sibel Gurun, Renee Parker, James C Eisenach, Michelle Vincler
BACKGROUND: CDP-choline (citicholine; cytidine-5'-diphosphate choline) is an endogenously produced nucleotide which, when injected intracerebroventricularly, exerts an antinociceptive effect in acute pain models mediated by central cholinergic mechanisms and alpha7 nicotinic acetylcholine receptors (alpha7nAChR). Previous reports also suggest that the peripheral cholinergic system has an antiinflammatory role mediated by alpha7nAChRs on macrophages. METHODS: We used male Sprague-Dawley rats to assess the antihypersensitivity and antiinflammatory effect of CDP-choline after intraplantar injection of carrageenan (100 microL, 2%)...
May 2009: Anesthesia and Analgesia
V Rema, K K Bali, R Ramachandra, M Chugh, Z Darokhan, R Chaudhary
Cytidine-5-diphosphocholine (CDP-choline or citicholine) is an essential molecule that is required for biosynthesis of cell membranes. In adult humans it is used as a memory-enhancing drug for treatment of age-related dementia and cerebrovascular conditions. However the effect of CDP-choline on perinatal brain is not known. We administered CDP-choline to Long Evans rats each day from conception (maternal ingestion) to postnatal day 60 (P60). Pyramidal neurons from supragranular layers 2/3, granular layer 4 and infragranular layer 5 of somatosensory cortex were examined with Golgi-Cox staining at P240...
August 13, 2008: Neuroscience
Sibel Demirbas, Salomon Stavchansky
The objective of this study was to determine, using a Caco-2 cell monolayer model, the extent to which the paracellular and transcellular routes are altered by citicholine (CDP-Ch) and DMSO in the presence of human serum albumin (HSA). The apparent permeability (Papp) of mannitol in the presence of 4% (w/v) HSA was investigated using 0, 0.5, 1.0, 2.5, 5.0, and 10.0% (v/v)) of DMSO. The Papp for mannitol ranged from 0.56 x 10(-6) to 0.89 x 10(-6) cm/s (mean 0.77 x 10(-6)). Increasing the concentration of DMSO does not appear to have an effect on the paracellular transport of mannitol and on the transepithelial resistance (TEER) of the monolayer, (P>0...
January 30, 2003: International Journal of Pharmaceutics
José León-Carrión, José María Dominguez-Roldán, Francisco Murillo-Cabezas, María del Rosario Dominguez-Morales, María Angeles Muñoz-Sanchez
Objective: To report new strategies in the treatment of persistent memory deficits following traumatic brain injury (TBI) using a combination of pharmacology and neuropsychological training. Study design: Two studies were carried out. The first study measured the regional cerebral blood flow (rCBF) of seven Patients with TBI with very severe memory deficits, once while resting and once one hour after the administration of citicholine (CDPc). In the second study, two groups of five patients of the same characteristics underwent an ecological neuropsychological memory rehabilitation program; during which time, one group was administered a placebo (Group A), and the other received CDPc (1~g/d v...
2000: NeuroRehabilitation
F Abad-Santos, S Gallego-Sandín, J Novalbos, M A Gálvez-Múgica
INTRODUCTION: Citicoline has a neuroprotector effect since it reduces the lesions of nerve membranes, by increase in the synthesis of phospholipids, and reduces the levels of free fatty acids. In this study we review the existing data on the efficacy of citicoline in the treatment of acute ischemic cerebrovascular disease and its sequelae, both in animals and in clinical trials involving patients. DEVELOPMENT: In various animal models citicoline reduces the volume of cerebral infarction and neurological sequelae and also potentiates the effects of other neuroprotector drugs...
April 1, 2000: Revista de Neurologia
G de Rosa, A Gulino, E de Rosa, M A Satta, A Aiello, O Makhoul, E Pasargiklian
No abstract text is available yet for this article.
August 31, 1980: La Clinica Terapeutica
E Bonavita, V Chioma, P Dall'Oca, C Fini, M Michelini, M R Ruggi, R Merli, O Ferro
No abstract text is available yet for this article.
April 1983: Minerva Psichiatrica
P L Bertoletti, G V D'Arcangelo, L Pacilli
No abstract text is available yet for this article.
March 1973: Minerva Anestesiologica
M Sappa, E Gramiccioni, V Manzari, F Dotta, M Matzeu
No abstract text is available yet for this article.
October 3, 1974: Minerva Medica
V D Petkov, A H Mosharrof, V V Petkov
The effects of adafenoxate (Adf), meclofenoxate (Mf), piracetam (Pc), and citicholine (CCh) on scopolamine (Scop)--impaired memory and exploratory behavior (experiments on rats) and on physical capabilities (experiments on mice) were studied. In the experiments with scopolamine (2 mg/kg i.p.) we used the step-through passive avoidance method to determine the memory changes. In the case of single treatment with the drugs tested scopolamine was injected immediately after training and Adf, Mf, and CCh at doses of 20 and 100 mg/kg and Pc at a dose of 100 mg/kg were administered immediately after scopolamine...
1988: Acta Physiologica et Pharmacologica Bulgarica
A H Mosharrof, V D Petkov, V V Petkov
The maze method for active avoidance with punishment reinforcement and the step-through method for passive avoidance with negative reinforcement were used to study the processes of learning and memory in 22-month-old rats, as well as the effects of meclofenoxate (Mf) and citicholine (CCh) on these processes. Meclofenoxate, administered in a dose of 50 mg/kg twice daily for 7 days using the maze-training method, increased the number of responses to the conditioned stimulus, when retention tests were made 24 hours and 7 days after training, whereas citicholine, applied in the same way in a dose of 10 mg/kg, shortened the latency of the responses with reinforcement during the training and increased the number of correct responses to the conditioned stimulus in retention tests 7 days after the training...
1987: Acta Physiologica et Pharmacologica Bulgarica
V D Petkov, R Kehayov
Using the methods for "staircase-maze" training with positive (alimentary) reinforcement and "steps down" passive avoidance with punishment (electroshock) reinforcement, we divided the experimental animals into three groups: "good", "intermediate", and "poor" learners. In the course of seven days the animals of the three groups were treated with five substances and were then tested for retention with both methods. Amphetamine at single doses of 0.1 and 0.5 mg/kg was injected s. c. 30 min before the retention test given on the 7th day after the end of training...
1987: Acta Physiologica et Pharmacologica Bulgarica
V D Petkov, J S Popova
The effect of adafenoxate (Af), meclofenoxate (Mf) and citicholine on the brain muscarinic receptors was studied in groups of ten male Wistar rats. The compounds were administered in doses of 50 mg/kg body weight twice daily for 7 days. One hour after the last treatment the animals were killed and the frontal cerebral cortex striatum, the hypothalamus and the hippocampus were removed immediately. Af and Mf were found to diminish significantly and to an analogous extent the density (Bmax) of the muscarinic receptors in the cerebral cortex, striatum and the hippocampus...
1987: Acta Physiologica et Pharmacologica Bulgarica
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